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Sequence of DNA2_HUMAN

EC Number:3.6.4.12

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3.6.4.12
DNA helicase
P51530
Homo sapiens
1060
120415
Swiss-Prot
Reaction
Other sequences found for EC No. 3.6.4.12

General information:

Sequence
show sequence in fasta format
   0 MEQLNELELL MEKSFWEEAE LPAELFQKKV VASFPRTVLS TGMDNRYLVL AVNTVQNKEG
  60 NCEKRLVITA SQSLENKELC ILRNDWCSVP VEPGDIIHLE GDCTSDTWII DKDFGYLILY
 120 PDMLISGTSI ASSIRCMRRA VLSETFRSSD PATRQMLIGT VLHEVFQKAI NNSFAPEKLQ
 180 ELAFQTIQEI RHLKEMYRLN LSQDEIKQEV EDYLPSFCKW AGDFMHKNTS TDFPQMQLSL
 240 PSDNSKDNST CNIEVVKPMD IEESIWSPRF GLKGKIDVTV GVKIHRGYKT KYKIMPLELK
 300 TGKESNSIEH RSQVVLYTLL SQERRADPEA GLLLYLKTGQ MYPVPANHLD KRELLKLRNQ
 360 MAFSLFHRIS KSATRQKTQL ASLPQIIEEE KTCKYCSQIG NCALYSRAVE QQMDCSSVPI
 420 VMLPKIEEET QHLKQTHLEY FSLWCLMLTL ESQSKDNKKN HQNIWLMPAS EMEKSGSCIG
 480 NLIRMEHVKI VCDGQYLHNF QCKHGAIPVT NLMAGDRVIV SGEERSLFAL SRGYVKEINM
 540 TTVTCLLDRN LSVLPESTLF RLDQEEKNCD IDTPLGNLSK LMENTFVSKK LRDLIIDFRE
 600 PQFISYLSSV LPHDAKDTVA CILKGLNKPQ RQAMKKVLLS KDYTLIVGMP GTGKTTTICT
 660 LVRILYACGF SVLLTSYTHS AVDNILLKLA KFKIGFLRLG QIQKVHPAIQ QFTEQEICRS
 720 KSIKSLALLE ELYNSQLIVA TTCMGINHPI FSRKIFDFCI VDEASQISQP ICLGPLFFSR
 780 RFVLVGDHQQ LPPLVLNREA RALGMSESLF KRLEQNKSAV VQLTVQYRMN SKIMSLSNKL
 840 TYEGKLECGS DKVANAVINL RHFKDVKLEL EFYADYSDNP WLMGVFEPNN PVCFLNTDKV
 900 PAPEQVEKGG VSNVTEAKLI VFLTSIFVKA GCSPSDIGII APYRQQLKII NDLLARSIGM
 960 VEVNTVDKYQ GRDKSIVLVS FVRSNKDGTV GELLKDWRRL NVAITRAKHK LILLGCVPSL
1020 NCYPPLEKLL NHLNSEKLII DLPSREHESL CHILGDFQRE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
26019
Nagase T.,Miyajima N.,Tanaka A.,Sazuka T.,Seki N.,Sato S.,Tabata S.,Ishikawa K.,Kawarabayasi Y.,Kotani H.,Nomura N.
Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
DNA Res.
2
37-43
1995
7788527
26020
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
15164054
26021
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
26022
Kim J.H.,Kim H.D.,Ryu G.H.,Kim D.H.,Hurwitz J.,Seo Y.S.
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties.
Nucleic Acids Res.
34
1854-1864
2006
16595799
26023
Masuda-Sasa T.,Imamura O.,Campbell J.L.
Biochemical analysis of human Dna2.
Nucleic Acids Res.
34
1865-1875
2006
16595800
26024
Zheng L.,Zhou M.,Guo Z.,Lu H.,Qian L.,Dai H.,Qiu J.,Yakubovskaya E.,Bogenhagen D.F.,Demple B.,Shen B.
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.
Mol. Cell
32
325-336
2008
18995831
26025
Duxin J.P.,Dao B.,Martinsson P.,Rajala N.,Guittat L.,Campbell J.L.,Spelbrink J.N.,Stewart S.A.
Human Dna2 is a nuclear and mitochondrial DNA maintenance protein.
Mol. Cell. Biol.
29
4274-4282
2009
19487465
26026
Balakrishnan L.,Stewart J.,Polaczek P.,Campbell J.L.,Bambara R.A.
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.
J. Biol. Chem.
285
4398-4404
2010
20019387
26027
Nimonkar A.V.,Genschel J.,Kinoshita E.,Polaczek P.,Campbell J.L.,Wyman C.,Modrich P.,Kowalczykowski S.C.
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Genes Dev.
25
350-362
2011
21325134
26028
Fortini B.K.,Pokharel S.,Polaczek P.,Balakrishnan L.,Bambara R.A.,Campbell J.L.
Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.
J. Biol. Chem.
286
23763-23770
2011
21572043
26029
Duxin J.P.,Moore H.R.,Sidorova J.,Karanja K.,Honaker Y.,Dao B.,Piwnica-Worms H.,Campbell J.L.,Monnat R.J. Jr.,Stewart S.A.
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication.
J. Biol. Chem.
287
21980-21991
2012
22570476
26030
Gloor J.W.,Balakrishnan L.,Campbell J.L.,Bambara R.A.
Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.
Nucleic Acids Res.
40
6774-6786
2012
22570407
26031
Shaheen R.,Faqeih E.,Ansari S.,Abdel-Salam G.,Al-Hassnan Z.N.,Al-Shidi T.,Alomar R.,Sogaty S.,Alkuraya F.S.
Genomic analysis of primordial dwarfism reveals novel disease genes.
Genome Res.
24
291-299
2014
24389050
26032
Ronchi D.,Di Fonzo A.,Lin W.,Bordoni A.,Liu C.,Fassone E.,Pagliarani S.,Rizzuti M.,Zheng L.,Filosto M.,Ferro M.T.,Ranieri M.,Magri F.,Peverelli L.,Li H.,Yuan Y.C.,Corti S.,Sciacco M.,Moggio M.,Bresolin N.,Shen B.,Comi G.P.
Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability.
Am. J. Hum. Genet.
92
293-300
2013
23352259