>Q9HQK6|diphthine synthase|EC 2.1.1.98|Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)|Swiss-Prot
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHIERDALRELAGAPADAL
>Q18JS3|diphthine synthase|EC 2.1.1.98|Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)|Swiss-Prot
MLTFIGLGLYDERSISIAGRDALQAADYVAAEFYTSYLVDATVSDLETAHDIDIDVRDRE
GVEQHPEDILRKAQSEDVAFLTAGDTMISTTHTDLRLRAIDRGIDTRVIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPYAHGAEGVPTSVTDSIAANRERGLHTVVYLDIKANRDEYLRA
SDAAEMLATDLEDMLAIAVARAGSPDPTVRADRLSALAEKDFGDPLHLLVLPGELHHLEE
EALAALADAPADMLNAVDSQ
>A6UU49|diphthine synthase|EC 2.1.1.98|Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)|Swiss-Prot
MIILAGLGLYDEKDTTLKTVEFAKKADKIYAEFYTAILTGTTIEKIEETLGKEITILDRE
KVELETEKLINESKDKDIMFLTAGDPMVATTHIDIAIEAKKKGIEVIILNAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKENSKMGYHTLCLLDIQAHNTRFMTANEGL
EVLLKIEEKRNENILNKDTKVVVVARAGSLKPKMVYGKIGDLLEYDFGAPLHCIIFTGNL
HFMEEDALKYLCENISE
>Q8TR14|diphthine synthase|EC 2.1.1.98|Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)|Swiss-Prot
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQQPDWLDKAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGAIIISETPYDTIKQNSELGLHTMIFLDIDKDKGYMTA
NHALELLLEVEKRRGEGIMERAVAVGIARAGSEKPVVKADYAESLKDFDFGNPLHILVVP
GKLHFLEAEALVKLAAGPGKIMEETE
>Q0W085|diphthine synthase|EC 2.1.1.98|Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)|Swiss-Prot
MLTFIGLGLYDQKDISVKGLEAIREADVVYAEFYTSRLMGATLEDMQELYGKPVKVLMRE
DVEQHPKDTVLSDAVDKKVVFLTGGDAMVATTHVDLRLRAKKMGIETRLIHGASIQSAVC
GLTGLQNYRFGKSATIAFPYKDIISETPYDTILMNKKNGLHTLLFLDIDREKGYMTVNRG
IELLLKVEERRKEGAVAGALCVGIARAGSPSPCVRAGRIEELQAFDFGGPLHIMVMPADL
HFLEEEALQDLAGLKLG
>A7IA21|diphthine synthase|EC 2.1.1.98|Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)|Swiss-Prot
MLTFIGLGLYDKTDVSEKGLAMIRSADYVFLEGYTSRLMGTNITELEAFYKKPVRLLLRA
DVEQHPDELLDCAARGNTVFLCAGDPMVSTTHADLRIRAAERGIPTAIIHGSSIVSAVCG
LSGLQNYRFGKSCSVPFPQGNWAPSSPLDVILENRTNRLHTLVYLDIQDDRYMTVNEGIC
LLEAMAQKKQVAIPFYVGVARAGSETSLVRAGTAETLRSADFGPPLHILIVPGELHDMER
EYLARFAGLC
>Q467Z4|diphthine synthase|EC 2.1.1.98|Methanosarcina barkeri (strain Fusaro / DSM 804)|Swiss-Prot
MLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSCLMGTNLEKMEKLYGKKVFLLSRE
DVEQHPDWLSKAKNRNLCFLTGGDTMVSTTHVDLRLRAEKLGIDTRLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIMRGAAAVGIARAGSEKPVIRADYAENLKDFNFGKPLHILVIP
GKLHFLEAEALVKLAGGPVGFMKEVE
>Q12XB4|diphthine synthase|EC 2.1.1.98|Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)|Swiss-Prot
MLDFVGLGLFDEKDISLKGLEKIHNADKVYVEFYTSILMGTDLEKMEMLYKKKITVLSRE
DVEQHAEDWLVDAKDSNVVFLTGGDTMVSTTHVDLRLRAADMGIKTTLIHGASIASAICG
LSGLQNYRFGKSVTIPHPYVSNRGVRVVSQTPYDTIKNNIEAGLHTAVFLDIDKDKGYMT
VNQAMEILLEVEGKLGEGVMVDRLAVGIARAGSPSPVVKADYIEALRDYYLGGPLHIVVI
PAELHFVEAEALVKLAGAPEGILENID
>Q2FQ45|diphthine synthase|EC 2.1.1.98|Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)|Swiss-Prot
MLIFVGLGLYDLDDISLKGLQAIKEADAVFLETYTSVLTGTTIEQMREKYGKDLIILKRQ
DVEQKPEPILTAAKNGIAVFLTGGDPMVSTTHADLRIRAHEQGIPTKIIHGSSIVSAVSG
LTGLQNYRFGKSCSIPYPAPKWFPKTPLDTILANLKQNLHTIVYLDIQENRYMSVHEGIE
LLEKLMEGSTDSIPLFVGIARAGSNSPVVAAGSSERLKLVDFGPPLHILVVPASLHEIEE
EYLKNFAGYDPQ
>Q58670|diphthine synthase|EC 2.1.1.98|Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)|Swiss-Prot
MLILAGLGLYDENDMTLKTLKFAKKAEKIYAEFYTAVLTGTTTEKIEEVLGKKIHVLSRK
DVEYNGYKLIEEAKDKDIMFLTAGDPMVATTHVDLAIEAKKKGIEVLIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIDENEKRFMTANE
GLKVLLELENRKKEGIINEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIPG
KLHFMEEDALKYLCENI
>Q8TXC7|diphthine synthase|EC 2.1.1.98|Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)|Swiss-Prot
MGELYLVGGGLSDVRDLTLRALEVLASVELVLVDTYTSVYDVSEGDLKRLLNGFGGDPEV
RMCSRRDLEERFFDLCEGYDRVALLSPGDPMAATTHVALVVEAADRGWDVEIINGVSVFT
AAPSKSGLEMYRFGRTATIPLNVRSVYPYDVLESNRQAGLHTLFLLEVAEDGEFVSVADA
ARYLLEIEREEGRGVLDPSDLAIAVVRLGFEDELVAWGTLEELSDWEPGEPPQALILPAS
RLREAEREYIRRVLPHIRDVRGV
>A2SQF6|diphthine synthase|EC 2.1.1.98|Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)|Swiss-Prot
MLTFIGLGLFDEYDVSVRGLDAIKSADTVFLEVYTSVLMGAPIERLEAFYGKKITPLYRE
DVEIHADKILDAAEFGNAVFLTAGDSMVATTHSDLRIRAADRNIPTTIIHGASITTAVCG
LSGLQNYRFGKSVSVPFPYGKWFPMTPIEVISANLKENLHTLVFLDIQKDKERYMKISEA
VDLLEEQARRVDAGIPLYVGIARAGSPEPTVHAGNAEEMKAFDFGSPLHILIVPATLHEI
EREYLERFAGLC
>A4FYP1|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis (strain C5 / ATCC BAA-1333)|Swiss-Prot
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKVEETLQKPITVLDRE
KVEYETNKLIEEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
SALLEIEEKRNENVISGETHAAVVARAGSTKPGLYYGKIKDLINYDFGTPLHCVIIPGKL
HFMEEDALKYLFENI
>A9A6D8|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis (strain C6 / ATCC BAA-1332)|Swiss-Prot
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKVEETLQKPITVLNRE
KVEYETNKLIEEAKNKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSVVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DTLLKIEEKRNEKVISGETYAAVVARAGSTKPGLYYGKIKDLINYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>A6VJP1|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis (strain C7 / ATCC BAA-1331)|Swiss-Prot
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTSMEKIENTLQKPITVLDRE
KVEYETNKLIEEAVDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSVVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRNENVISGETYAAVVARAGSIKPGLYYGKIKDLINYDFGTPLHCVIIPGKL
HFMEEDALKYLFENI
>Q8PUH9|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)|Swiss-Prot
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A3CWF9|diphthine synthase|EC 2.1.1.98|Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)|Swiss-Prot
MLTFVGLGLYDLGDISVKGLEYVRNADTVFLEAYTSRLMGTDTAAMEAFFEKDIRVLGRE
DVEQTPREILECAAAGRVAFLTGGDPMVSTTHADLRMRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGRSCSVPFPAKGWFPTAPIETIAANLALNLHTLVFLDIQNDRYMRVPEAIA
VLEEMAEKRGIEPPALYVGIARAGSERPVVAAGAGANLKEMDFGPPLHILAVPADLHPME
REYLETFAGL
>Q6LZN6|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis (strain S2 / LL)|Swiss-Prot
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISEETEVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>B8GIF8|diphthine synthase|EC 2.1.1.98|Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)|Swiss-Prot
MLTFVGLGLYDAGDISVKGLEAVRASDAVFLEYYTSRLMGTTIEDLVRAYGKEVIVLARA
DVEQHPEPILDAAAAGDVVVLTGGDPMVSTTHMDLRLRAAARGIPTGIIHGASIQTAVCG
LTGLQNYRFGKSCSVPFPQKNWFPLTPYEVVRQNLAADLHTLVYLDIQQDRYMRVGEAID
LLEEMAVRVGGSITTYIGVARAGSVSPVVRAGTADHLRGIDFGGPLHVLIVPATLHPVEQ
EYLEVFAGLSV
>A4YHI8|diphthine synthase|EC 2.1.1.98|Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)|Swiss-Prot
MADIYFVGLGLSKRFLTNASLEVLKGSDVIYADIYTSISCDINEKTLREITGKEIIPATR
EVLETKEKEIYKLLDSGKNVAIAVVGDPMIATTHVSLATGARARGHRVSVIPGVSVHCYM
ISRSMLSSYKFGKSVTVTFPVLDKLDYTPYRVIKTNRELGLHTMVYLDLKETGIMTADLA
LNYLKKMESDIGDKVILDDDLVVIGERLGCADERVRAMKVVDALNQKFGAPPHIIIVPSR
NLYEMEVEGLKCLS
>Q9YDI2|diphthine synthase|EC 2.1.1.98|Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)|Swiss-Prot
MARGREAVTLLLVGWGYAPGMQTLEALDAVRRADVVYVESYTMPGSSWLYKSVVEAAGEA
RVVEASRRDLEERSREIVSRALDAVVAVVTAGDPMVATTHSSLAAEALEAGVAVRYIPGV
SGVQAARGATMLSFYRFGGTVTLPGPWRGVTPISVARRIYLNLCAGLHTTALLDVDERGV
QLSPGQGVSLLLEADREYAREAGAPALLARLPSVLVEAGAGGGHRVLYWSSLERLSTADV
EGGVYSIVIPARLSGVEEWLLAAASGQRRPLEYDRSVYETVEENCKKGVYMEPV
>O29866|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)|Swiss-Prot
MLTFVGLGLWDVKDISVKGLEAVREADEVYVEYYTSKLLSSIEEMEEFFGKRVVELERSD
LEENSFRLIERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVCGL
TGLHNYRFGKSATVSWHRSQTPVNVIKANRSIDAHTLLFLDLHPEPMTIGHAVENLIAED
AQMKDLYAVGIARAGSGEEVVKCDRLENLKKIDFGKPLHVMVVLAKTLHFMEFECLREFA
DAPAELERLVA
>B9LV13|diphthine synthase|EC 2.1.1.98|Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)|Swiss-Prot
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSRLVGADVDDLEAYHDTEIEVRARE
GVEQDPEAILAAAEDGHTAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVIDTIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWEDALAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPAELVEE
>Q5V2B7|diphthine synthase|EC 2.1.1.98|Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)|Swiss-Prot
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLEDTLETSIERRDRA
GIEQDPEPILEAAESEHVVFCTAGDTMVSTTHADLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEES
DDTYMTASQAATMLSEPFPDTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPG
SLHPLEADTLESVAGAALE
>B0R4W9|diphthine synthase|EC 2.1.1.98|Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)|Swiss-Prot
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHIERDALRELAGAPADAL
>Q971V1|diphthine synthase|EC 2.1.1.98|Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)|Swiss-Prot
MPTLKLIGLGLSAKFVTREAIDEISKCNVVLFESYTSLSCDINLDFIKFLNKNVIIVDRK
FIENNIKEIIKLLKEKEDVCIVTIGDPMIATTHVSLIVEVKDKGYNFKVIPGISVHCYII
SKSMLSSYKFGKSVTITYPYNNKIDTTPYDVIYDNFIRGLHTILYLDLKEDKIMTAKEAV
ELLIEMEKIKKQGLVSDDRIIIVGQRLGCDDEEVVALRLKEVFNYKFKEPPHIIVFPTDK
LHFMEVEALKCLMK
>Q9HJT0|diphthine synthase|EC 2.1.1.98|Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)|Swiss-Prot
MLNIIGVGLRGTGSITFDEFDALRTSDFVYADMYTSIGQPGLIRKISAMIDRDILPLTRD
EIENGSILPQAASKNVSLIVVGDPLMATTHNELRYEAMNQGIGVRIFENASILNAAIGKA
GLMVYKVAPPVSLPRISEKFFPLSVIDKIKRNADLGLHTPVLIDLEDQENIPLHDALASL
LEMERRREYSGIIREICVLSRISFPDEKILFGRIEDMMQQEVNSPYMMFILSKLDDNERR
FLSLFSESVSKVSDARS
>C5A3K4|diphthine synthase|EC 2.1.1.98|Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)|Swiss-Prot
MALYFIGLGLYDERDITLKGLKTARKCDKIFAEFYTSLLAGTTMERIEGLIGKPIIRLSR
EDVELNFEKIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AVTGLQIYKFGKSATVAYPERNWFPTSYYDVIKENRERGLHTLLFLDIKAEQNRYMTANE
AMEILLQVEDMKKEGIFTPETLVVVLARAGSLNPTIRAGYVKDMIHEDFGRQPHVLIVPG
RLHVVEAEYLVEFAGAPEEILEEV
>Q5JFE7|diphthine synthase|EC 2.1.1.98|Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)|Swiss-Prot
MVLYFIGLGLYDEKDITLKGLETARRCDKVFAEFYTSLLAGTTLEKIEELIGKPIVRLSR
EDVELNFERIVLPEAKDKDVAFLTAGDPMVATTHSDLRIRAKKAGVKSYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRDNKERGLHTLLFLDIKADQNRYMTANE
AMEILLKVEEMKGEGVFTPETLVVVLARAGSLEPTLRAGYVRELINEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEKILEEV
>B6YXP9|diphthine synthase|EC 2.1.1.98|Thermococcus onnurineus (strain NA1)|Swiss-Prot
MAIYFIGLGLYDEKDITLKGLETARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELQFERIVLSEAKGKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAI
AITGLQVYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGEGVFTPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGRQPHVMVVPG
RLHIVEAEYLVTFAGAPRKILDEV
>Q979Z8|diphthine synthase|EC 2.1.1.98|Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)|Swiss-Prot
MLNIIGIGLRGTGSLTLDEFDALRTSDIVYLDIYTSIGPKDILEKLRNIADREIIPADRN
MIESESILKDAEKLNVSLLVIGDGLTATTHNQLRYSAMEKGIKVKIFENASAVNTAAGKI
GLLHYKVGPPVSLPFVSSNFFPLSVIDKVKRNYDSGLHTPILIDLKDGQNMPFASAWNII
MEMQKRKGVCNNRRKCMRCLEAFISG
>Q2NFJ8|diphthine synthase|EC 2.1.1.98|Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)|Swiss-Prot
MLYFIGLGLFSEDDISYKGFKALKSVDCIYAEFYTAKLMGGNIDNLIEKLDVPFITLKRE
DVEDANVIIKEAMTKDIAFVTAGDSLMATTHTELYVEAINKGIKTQIIHGSSIFSAAPGI
SGLQAYKFGKTTTVPFPDENFFPHSPYDAIKLNSQMGLHTLVLLDIQAHKDRYMTVNQAL
DYLSKVESERKEHVFDDDRIVIGIAQAGSKHPIVKGGRVSDVKNFDFGKPLHCIIVPANL
HFIEAEALITLADVDKELLKDFL
>O27902|diphthine synthase|EC 2.1.1.98|Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)|Swiss-Prot
MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRSVKVLGRG
EIEEERIPIERALELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGL
AGLQAYKFGRIITIPFTSDNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTATEGL
RYLLKASEKLDDGTISGETLAVVIARAGSEKPLVRADKIATLVEEDFGDPLHCLVVPAGL
HFIEADYLVEIAGAPRAVVERMIL
>A0B879|diphthine synthase|EC 2.1.1.98|Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)|Swiss-Prot
MLFFVGLGLYDERDISVKGLEIVRCADAVYAEFYTSRLMGTSIERLEQLYGREIRMLSRS
EIEGEPEWLEHARDRNVALLVGGDPMISTTHLDLRLRAIEMGIDTRVIHGSNIASAVPGI
TGLQNYRFGRSATVPFPHIVRGKRIVSSTPYNAVKDNLRRDLHTLLYLDIQDERFMCINE
AAALLIEVANGSGDEDFASNLAVGIARAGSEDMCVRAGTLLELKTYSFGPPLHVMVIPGR
LHFMEAKALRMLAGAPEELLSGYEL
>A6US81|diphthine synthase|EC 2.1.1.98|Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)|Swiss-Prot
MLVMAGLGLYDELDVTLKTVEFAKKVDKIYAEFYTAILTGTTIEKIEKTLQKEITVLNRE
KVEYETNKLIEEAKEKDIMFLTAGDPMVATTHVDIAVEARKKGIEVIILNAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLSLGYHTLCLLDIQTDKQKFMTANEGL
SVLLEIEEKRKEKIIDENTKVLVVARAGSIKPGLFYGKIKDLIKHDFGTPLHCVIILGKL
HFMETDALKYLFENI
>Q3IS55|diphthine synthase|EC 2.1.1.98|Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)|Swiss-Prot
MLTFVGLGLYDERSITVAGREALRSADRVFAEFYTSKLAGATVEELQNHHDIDIEVRDRA
GVEQEPGPILDAAEAGGAVFLTAGDTMISTTHVDLRLRADNRGIETQIIHGTTAGAAAAS
LSGLQNYRFGKATTLPFPYAHGGEGVPGSVLDTIADNRKRGLHTLVYLDIKVGTGPRGPD
PDHEEYMTADYAAELLAEDLDTVGVAIARAGSPDPVLAADRLSALADRSFGDPLHLLIVP
GDLHVVEHDALVALAGAPESALPDPV
>Q9UZ31|diphthine synthase|EC 2.1.1.98|Pyrococcus abyssi (strain GE5 / Orsay)|Swiss-Prot
MALYFIGLGLYDEKDITLKGLEIARKCDYVFAEFYTSLMAGTNLERIEKLIGKEIRVLSR
EDVELNFERIVLPLAKDHDVAFLTAGDPLVATTHAELRLRAKKFGVESYVIHAPSIYSAI
AITGLHIYKFGKSATISYPEKNWFPTSYYDVIKENLERGLHTLLFLDIKAEKGKYMTANE
GMKLLLKVEDMKKEGVFTQETLVVVLARAGSLNPVIRAGYVRDMIREDFGSPPHVLIVPG
RLHIVEAEYLVEIAGAPREIIR
>Q8ZXR9|diphthine synthase|EC 2.1.1.98|Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)|Swiss-Prot
MLSLVGLGPGRGYVTEAAAEAIKNADCVFYEDYTAPLDVEALRRLARGEPIRLTRADLED
HSGRKIFECLKEGKRAVLVTGGDPMLATAHAAILALARRRGYRVEVVPGVSIICAAFSLS
CLSIYKLGGVATVTYPRGGVYSTRPYDLVEQNLQRGLHTLLLLDVREDGRFMPPREGAEV
LLQLEERVGRGLFKEDLPIVVVYKVGWGGSAVYATLGEIARSDLEGPAVFIVPSRLGPVE
KECLEGLSARSSTR
>A3MU14|diphthine synthase|EC 2.1.1.98|Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)|Swiss-Prot
MLYIVGIGPGPGYATERAIRAIEEADCVFYEDYTGPIDVETLRRAAKTPPIRLTRRDLED
ESGRKVLECLREGKRAVLATAGDPMLATAHAALIAAARARGHPVEVVPGVSIICAAFSAA
CLSIYKLGGVATVTYPRGGVYSTRPYELAEANLARGLHTLLLLDVREDGSFMPPRDAAEV
LMALEERERRGVFTPQRPAVVVHRLGWGGGVVVGPLGAVAKWDGEGPAVLIIPAQLGPVE
KECLEAVAQRI
>Q8U377|diphthine synthase|EC 2.1.1.98|Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)|Swiss-Prot
MPLYFIGLGLYDEKDITLKGLEIAKRCDKVYAEFYTSLMAGTTLEKIEEVIGKKIIVLNR
EDVEMNFEKIVLPEAKEKEVAFLTAGDPMVATTHAELRIRAKRMGVESYVIHAPSIYSAV
AITGLHIYKFGKSATVAYPEGNWFPTSYYDVVKENLERGLHTLLFLDIKAEKGKYMTANE
AMELLLKVEEMRGENVFTPNTLVVVLGRAGSLNPTIRAGYVKDMIKEDFGKQPHVLIVPG
KLHVVEAEYLVEIAGAPKEILEQFAPRKM
>O58456|diphthine synthase|EC 2.1.1.98|Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)|Swiss-Prot
MVLYFIGLGLYDERDITVKGLEIAKKCDYVFAEFYTSLMAGTTLGRIQKLIGKEIRVLSR
EDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIRAKRAGVESYVIHAPSIYSAV
GITGLHIYKFGKSATVAYPEGNWFPTSYYDVIKENAERGLHTLLFLDIKAEKRMYMTANE
AMELLLKVEDMKKGGVFTDDTLVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPG
KLHIVEAEYLVEIAGAPREILRVNV
>A1RU15|diphthine synthase|EC 2.1.1.98|Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)|Swiss-Prot
MFYIVGIGPGPGYITERAIQILQEVECIFYEDYTGPLDVATLRRYARVEPVKLARRDLED
ESGRKIFECLQEGKKAALVTAGDPMLATSHAALITLAKAKGYSVEVVPGVSIICAAFSAS
CLSIYKLGGVATVTYPRGGVYSVRPYELVEQNLARGLHTLLLLDIRDDGVFMSPRDAAEV
LLTLEGRERRGVFTRDRRVVVVSKLGWGGSVLYAPLGEIVQSEMEGPAVFIVPAGLNPVE
RECIKTFSK
>B1YAU2|diphthine synthase|EC 2.1.1.98|Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)|Swiss-Prot
MFYIIGVGPAPGFITEKAAQILREADCVFYEDYTGPIDVETLRRYARSPPTRLTRRDLED
ESGRRVLECLSRGKTAVLATAGDPMLATSHAALISIARSRGYSVEVVPGVSIVCAAFSAS
CLSIYKLGGVATVTYPRGGVYSARPYELVEQNLARGLHTLLLLDVREDGVFMPPRDAAEI
MLKLEEREKRGVFDKGRPVVVVPKLGWGGRPAYLPLGELLGSDLEGPAVFIVPGGLSPVE
RECIEALSVLKSR
>Q97TX8|diphthine synthase|EC 2.1.1.98|Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)|Swiss-Prot
MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEA
DRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTAN
EALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIP
GNLHYMEADAIKWILRS
>A3DLV7|diphthine synthase|EC 2.1.1.98|Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)|Swiss-Prot
MLYFIGLGLSIKHLTLEAIDALRDVEKIYVDTYTNIVPDFSLDKLVSLVGEEKEFVMAKR
EFLEGKNIHFIVEEASKKNIAILVPGDPFIATTHDAIRVEALRRGIKVKVINGLSIYSLA
PSRTGLQAYKFGKTVTLVYPEYFKPYSTIETIYDNLDRNLHTLLLLDLKIEENKAMTIPE
AVDILIDLDERGVLENIIGVGLAQLGSSMEKIVADRLADLKNYTYPPPPHSIIIVAKPHP
IELDNLHYVCGLPEHIYRRYSVSKTYP
>C3N5D1|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain M.16.27)|Swiss-Prot
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>C4KGZ7|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)|Swiss-Prot
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>C3MPQ5|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)|Swiss-Prot
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>C3MYP9|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)|Swiss-Prot
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>C3NHR8|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)|Swiss-Prot
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>C3NDY5|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)|Swiss-Prot
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>A0A533U6A1|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGLGISGPDGIGLDTLQILKKADIVFFEIFTSPISQPELLKIKNTVKGEFKTAARW
MVEDGKIILKDARKKNVVLLSYGDPYIATTHIELRTRAILEKIKTKTIHAASAITSLVGE
CGLHYYKVGKPVTMMNEKQSIPSVYYTIYENLIAGSHTIIILEYNNDKKFFLDPKDAFSN
LLLAEKEQKRNVIDKSSFVIVASRIGAKNQKIVAGKLSTLKKIDFGKPPHSIIIPGRMHF
TESDALKVLAKCLDEPFDNSSRIKKISDQMLEKYIPKARKALEEVTKQFKEDKSLQSVLE
NANLYLYDAEKFQSEGKEELAVLSIGYAEGLIDALRFSKGIDPWA
>A0A497F038|diphthine synthase|EC 2.1.1.98|Candidatus Verstraetearchaeota archaeon|TrEMBL
MALWEANRLGELIFIGLGLNGIKSISLEGLEIIKSADEVFIELYTSIMPDFSLKELKSVV
GKEVKVLSRRDLEDLSGKAVLDEAKKGKRVALLTPGDPLIATTHISLRLLAEKAGVTTKV
IHSSSIISAAISASGLHCYKFGRIVTITSGSETPYDVLRDNMRRGLHTLFLLDMDVERGY
FMSVSEALNSLLEIENKRKENVISPSTLALVLSRVGSSTSCLKCDVILNLMKLDFGSPPH
AIIIPGRLHFMEAEALITLADAPKKLVENLVSRS
>A0A523BEA6|diphthine synthase|EC 2.1.1.98|Candidatus Verstraetearchaeota archaeon|TrEMBL
MTLNFIGLGVYDEKGITLYGLELAKNSDIIFLEKYTSIIPYLNIDSLEKIIGKKIIIIDR
KFIEDGEIILKKAKDYNVSILTPGDPFIATTHIELRIRAEKQGIKVNIAHAPSIISVIPG
EIGLQNYKFGRSATITFPDNYSEVPYDTLKQNLSLGLHTLFFLDLREDKYMSVNDGLAML
MEMENKRKENIITSDMLVIGIARVGGPNQFIKGGRISDVIKIDFGPPPHCIVIPGKLHFM
EEEALIVFAKIDRELLKNRRI
>A0A7C4RFI4|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MVLYLVGLGLGSLDYRSIKAIKELKNCYAAYLDTYTGFISKDLLDWLKREFSGKLILATR
RDLEDNLGKVVEEARDTNIAILVPGDPLVATTHVSLIVEAAKRKIPYRIIHGVSIYSAAI
SITGLQAYKFGRTTTLAKFGDPRESYRIIKENLERGLHTLVFLDTADGGLTIPEALRRLL
ESEVSLNQGIVREDTLAIGLARIGLQEELVKVNIVRELILEDYPPPPHALIFPGELHFME
VEALTKLYDVDEEMVKRHKPPVYEKERVWKYITKTRDVAKNLKIKETHKDLEEILEIASS
YIEDAERFWSSGELFNALASIAYAEGLLDCLRMIGKIEFQWL
>A0A6V8E013|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MADDEVNPKETGLMLIGMGPGTVDSMTNEAISVAKSADYRRYEAYTALWPDDELNSLEGI
IGPIEKVMRPEIENPDEILTLAKHSLVAVLIVGDPLQATTHIDLQLQAIEQGINCSVIHG
ISITNLVTGAIGLSNYKFGRQTTLTYPYSGWVATSPLEVIALNRQMGQHTLALLDLDPTG
AGTGQQKPMAPADAVISMKSMIEKVEDNIEEMSTDNDLARLKKQSLEEFIALESCDLPVV
LCSDMGTSQQKMIYTSLADLSELQGGRMNCLVFPASTSDVEEKALLRWLKEE
>A0A7J4G4N0|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTGTRAPRFTMTEEDLGAGLWLIGLGPGDLGQMTRGALVLSQACNYRFLEGYTAVLPIEE
ENALEGLVGPWGRLMRDEVEKPEKILDLAQHSSVALLVVGDPMQATTHIDLEERCAELNI
PFKVIPGLSATSLAISLSGLQSYRFGRQVTLTYSYGDYLPTSPLELIDKNYNNNLHTLML
LDLDPTGMGIEKPKPMAPKVAVELLQRMIEKISERDGGLKPSLQIPIVDWDGILLSDIST
NQQRIEAGNLGKLSNYQGGNIHSFILPAKMTDEEKKAFTRRMRK
>A0A1L3PZL6|diphthine synthase|EC 2.1.1.98|Methanohalophilus halophilus|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNADKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKDTNIVFLTGGDTMVSTTHVDIRLRAMEMGIETRLIHGSSIVSAICGL
TGLQNYRFGKAATIPHPYTSTRGNTIISETPYDTILRNRQMGLHTAVFLDIDMNKGYMTV
NQGLELLLKIDEKRGDNLIKGSIAVGIANAGSEKPIVKADFAENLESYDFGSPLHIVAIP
ADLHFVEAESLVKLADAPESILEEGDEN
>A0A843AEQ2|diphthine synthase|EC 2.1.1.98|Methanobrevibacter arboriphilus|TrEMBL
MLYFVGLGLFDEKDISLKGLKALKSVEIVYAEFFTSHLFGSSFKAIEELIGKEIKVLNRH
EVEEENVFMKEAIKGQDVALIIGGDPLIATTHTDFLVEAKKKGIETEVIHGSSILSSAPG
ISGLQAYKFGKVTTIPFPDENFFPQSPYMAIANNLLNDAHTLVLLDIQAHKNRYMTVNQG
LGYLMKVKDDLISNGKDNEAIIDENTLAIGIARVGSKDVVVRADKIVELIDFDFGGPLHC
IAIPSKLHIVEAEYLVEVCGVPREILDGV
>A0A6B0HAR4|diphthine synthase|EC 2.1.1.98|Natrialba sp. INN-245|TrEMBL
MLTFIGLGLYDERSITVEGQRALRDADRAYAEFYTSKLIGASVPDLEEAHGIEIDVRDRA
GVEQHPEDVLEAAEDEDVVFLTAGDTMISTTHVDLRLRAHERGIDTQVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDDNRADGLHTVVYLDIKVGYDPTNSQ
TANRPEDTVGYDRADGDQYMTADVGAALLAEVYPELVGVVVARAGSPDPLVDAATMTELA
ERSFGDPLHLLVIPGECHLLEADALVELAGVDREALDIV
>A0A2Z2MTE4|diphthine synthase|EC 2.1.1.98|Thermococcus barossii|TrEMBL
MAIYFIGLGLYDERDITLKGLETARKCDLVFAEFYTSLLAGTTLDKIEKLIGKPIRRLSR
EEVELHFERIVLSEAKERDVAFLTAGDPMVATTHADLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTMLFLDIKAEQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLNPTLKAGYVKDMLKEDFGGQPHVMVVPG
RLHIVEAEYLVAFAGAPREILAKV
>A0A2G4J1U1|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLSFVGLGISGFESISIEGLDAISKADIVYLEQFTSPISKSDLEKIQNAVKGEFIPAKRW
LVEDGNEILEMAKEKNVILLSYGDPYIATTHVELRARAIENKTQTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEVKSLTTPYYVIYKNLIEGNHTILLLEYNQNKDFFLDPKDALKG
LLETEKGERRKVLTESSYVIVASRIGFKDQTIISGKISNLLKIDFGKAPHTVIIPGKLHF
TESDALKLFGKCTDEPFDNSENTQKISIQMMKKYVPMVRDALEEIKPYYENENEFKIILE
NAELYVKDAEKFLDDGHDEVAILSIGYADGLVDALRMAKGLEPKM
>A0A533WC77|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGLGISGIDGISSNALNIIKKADIVFLENFTSPIGKQEVSKIRKIAKKKLKIASRW
MVEDGKAILLASKGKSVVLLSYGDPYVATTHIELRTRAENEKIRTKTIHGASAITSLVGE
CGLHHYKIGKPVTIMRELLSLTTVYYTIYENMIKNSHSILILEYNNDANFFLDPKEAFSS
LLLTEDSEKRSVINESTFAIVASRIGTKNQAIIAGKLSSLMNTNFGKPPHTIIIPGKMHF
TEHDAIKVFAKCLDEPLDNSSKIQKISEQMLLKYIPKARKALEEVRRVFKDDKVLQPVIE
NAQLYLDDAEKFQSEGKDELAVLSVGYAEGLIDALRLSKGIDPWAQSL
>A0A8J8EJ68|diphthine synthase|EC 2.1.1.98|Thermococcus sp. GR4|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELQFERIVLSEAKGKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAI
AITGLQVYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGEGVFMPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGKQPHVMVVPG
RLHIVEAEYLVTFAGAPRKILDEV
>A0A7J4GDP3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPSASQSASRKKTSTDSTSRLGTLRWRITLMMGRRAPRFTMTDGALPAGLWLIGLGPGDL
GLMTSQAIEHARACEHRFLEGYTATLPADQETLLENLIGPWQRAMRPTIEEPSEILALAR
DTSVAILVVGDPMQATTHIDLEAHCDEQSIDFSVIPGLSATSLAVSLSGLQSYRFGRQVT
LPFAYGDYLATSPLELIDANYTNNLHTLVLFDLDPTGMGVDEPQPMQAAAAVELLSRMVD
RLAEREGSTRESLAAPIAKWDGILMSDLGTPDQRVVSGDLEELAKVEGGRMHCLVLPADF
AGLEREAYERRRGQS
>A0A3A5WF64|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MVFAMPRGASGLSMAAGLLLIGMGPGGVSGMTRAAIQAAKSADHRRYEAYTALWSKDSLS
ELEEEIGPIQRVMRPEVEDPVEILELAKSQTVALLIVGDPLQATTHVDLQLQAKESGIDC
TVIHGVSITGLVTGAIGLSNYRFGRQTTLTYPYGGWIATSPLEVIATNRFQGLHTLALLD
LDPTGEGIGGQKPMQPSDASQAMYAMAEKLSQSVEEMSEDSVLDSLKIQACREICSNIDS
LMVVLCTDMGTENQTISYLSLEQLSLADTGGLHCLVIPAKPTDVEEIALNRWSKK
>A0A3A5VME6|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTLAPSKRVGGLSMAEDSFVLQNIPKTGLLLIGIGPGSVGGMSLEAIEAAKIADHRRYEA
YTALWPSEELELLERTIGPIERVMRPEVEQPSELFALARSSLVALLVVGDPLQATTHVDL
QLQAMEHDIECKVFHGVSITTIVTGAVGLSNYRFGRQTTVTYPYGGWIATSPLEVIAVNR
FRGLHTLVLLDLDPTGQGTGDQKPMKPSDAKRSIELMWDKLDEGLKQSTEPTESPLIASQ
EFAFKAFLEGEKDNLPIVLCSDMGTPEQKIILTNLGGLENLEGGRLNCLIIPALTSEVED
KALLRWKQE
>A0A6V8EAG9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MAEDSDKPKQASLVLIGMGPNMLTSMTEEAIVAAKSADFRYYEAYTAMWPIEELERLESR
VGPIKKVMRPEVEQPEEILNLAKENTVAVLVVGDPLQATTHVDLQLQAEENGIDCRIIHG
ISITNIVTGAIGLSNYKFGRQTTLTYPYSNWIATSPLEILAMNRIMGHHTLALLDLDPTG
AGTGKQQPMRPKDAVISIGLMIEKLSSGIEDINDNDSLSKLKKQAINELVATKFADWNVV
LCSDMGAEDQSIIYTNLADLADFPGGNMNCLVFPASTSDVEEKALLRWSREEG
>A0A1V5T064|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ADurb.Bin294|TrEMBL
MLIFVGLGLYDLDDISLKGLQAIKEADAVFLETYTSVLTGTTIEQMREKYGKDLIILKRQ
DVEQKPEPILTAAKNGIAVFLTGGDPMVSTTHADLRIRAHEQGILTKIIHGSSIVSAVSG
LTGLQNYRFGKSCSIPYPAPKWFPKTPLDTILANLKQNLHTIVYLDIQENRYMSVHEGIE
LLEKLMEGSTDSIPLFVGIARAGSNSPVVAAGSSERLKLVDFGPPLHILVVPASLHEIEE
EYLKNFAGYDPQ
>A0A2J2HDV5|diphthine synthase|EC 2.1.1.98|Vulcanisaeta sp. EB80|TrEMBL
MGKKNPTLYLVGLGLSPGNLTIDALNVIRSVDKVFMETYTSKAPGELIKQIMGIRHDIVF
LSREDLEDRSGNAIMSELSKGRDAALLVIGDPMMATAHAAILVIVKRLGFEVRIINSVSI
VCAILSQLGLSPYKLGPIATITYPRMGILSMRAYEILNDNLRRGLHTILLLDIKDGNEFM
SASEAIDLLRKMEENGKLGIINNGLLVIYAARIGWENQSIVVSTINNVPSLGETPHTIII
PGLLNPVEIDYLTYVLYADKDLVLKHQRWVNKLMNGNWQK
>A0A7C0YBT4|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYFISLGLHDEKDMSLKALETARACDLLFAEFYTTKLETTKEKLEQLIGKPIKLLSRKD
LEENYQAILEEAKDKKVGLLVGGDAFVATTHAALRLEAMKQGIETRVIHGSSIISAIGET
GLHVYKFGASVTIPFLEKTKGKLPESVYEVIKLNKARGLHTLC
>A0A7C0UTT8|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
LKLIGLGLFNEKDITLRGLEEAKKSDKLFIELYTSKWHGNLKNLEELVGKKIEVLKREDL
EEKSSKILEEAKIKDIAIFVQGDPLVATTHFTLLQEAKKLGIKTKVVHNASIVSAIAETG
LHLYKFGATVTIPFPEKTKGKLPESVYEVIKMNKARGLHTLCLLDVIGEKNKYMTPVEGL
KILLKLEELRKEGALSPESKVVVFANAGSEKPLIFYRRVEEIIKKNINATPAVLIIPGIL
HFTEKEVLSLLCSEE
>A0A2G1X8W4|diphthine synthase|EC 2.1.1.98|Halorubrum sp. C3|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSVLAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A8J7X5E2|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeota archaeon|TrEMBL
QIYKFGRTTTIAYPEGSYFPKSPYDVVKENHMRGLHTLCLLDVKADEKRYMTVGEGTQLL
LKMEYERMQNQIREDTQIVGVARLGSEDAVIAYGSLKKISNYVFGEPPHALIVPGKLHEM
EE
>A0A0E3QUV9|diphthine synthase|EC 2.1.1.98|Methanosarcina barkeri MS|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSYLMGTNLEKMEKLYGKKVFLLSRE
DVEQHPEWLSEAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGSSIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIMRGAVAVGIARAGSEKPVVKADYAEKLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAEAPAGFMNEAE
>A0A842M7X2|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
MLYIIGLGLYDENDISIKGMKTLKECDRIFAEFYTAKLKDQSLSTIKEKTGKDIQIIGRK
EIEEEMKPLKYAKREDVALLVPGDPLAATTHSTLILEARRKNIKTGIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEENYFPHSPYLTIKNNLKYDAHTLILLDIKAEENKYMNANQGL
KYLLKVEEERKENIISLDSLAVVLARVGSSNPLIRADRIKKLVVEDFGGPLHCLIIPSKL
HFLEAEYLIEIGGAPPEILEGRI
>A0A832Z6E9|diphthine synthase|EC 2.1.1.98|Archaeoglobus profundus|TrEMBL
MLIFVGLGLWDEKDISYKGLEIARRANEVYVEFYTSKLMGSSLDKLQKFIGKEVKVLERS
DLEENSEWLIQRAKDKDIVILIPGDPMIATTHSALRLEAEKRGVKTKIIHSASIVCAVCG
LTGLHSYRFGKSATVCYPYKGIIPRTPLNVIKQNLSIDAHTLLYLDLHPKPMTIREAIDI
LMKADDDNILKDLFGVGIARAGSDNPFVKCDKLLNLRKVDFGSPLHVLVVLARTLHFTEY
EYLRMFASAPEELKKIVV
>A0A842NJD0|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopelagicus sp|TrEMBL
MLWFIGLGISGISELSERTRNIIKNAEMVYLESFTSPISETEKEELESICNGEFKIAKRW
LVEDGNEIIDNAKEQETVLISYGDPYIATTHLELKTRATNDKIETKTIHSSSIVSSLIGE
VGLHYYKVGKVLTIMNDPKSMITPYNTIFDNLLNKTHSVILLEYNEDKSFFLQPQDALSL
LLDVEKTQNRKVISQETFAIVASRIGRDDQKITSGRITNLIKKEFGESPHSIIITGKLHF
TESDAIKVITECLDEPIDNSADVKSISEQMIEKYVPMVREALEEIRPHYEDLKEYENILI
NAKLYIDDAENFLKEGKKEYAVLSIGYADGLVDALRIAKGFDPKM
>A0A843LZA8|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFLKSYTMFYLVGLGLFDAGDISLKGLECLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A1D2RGG3|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon IMC4|TrEMBL
MLYIIGLGLYDEKDISVRGMEALKNCQKAYAEFYTNAFHGKLENLRGEIKILSREDVEGK
AAFIKEAKNKDVAFLVPGDPMAATTHVDILLRAKKLGVETRIIHSSSVFSAIGETGLQIY
KFGKTTSVVFPEKNYFPQTPYDVLKENLNAGLHTLLLLDVKADEERYMSVGDGIGILLEI
EKKRKENVFTEETMCIGAARLGGGSAIKYARAKDLADFDFGPPPHAIVVPGKLHFVEEEF
LDYLK
>A0A3M6K948|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPISKSDLTKIKKATKGEFRPAKRW
LVEDGNEILENSKKKKVVLLSYGDPYIATTHIELRERAIKDKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LLETEKGQRRKVISPSTFAIVASRIGFKDQEVISGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDDPFDNAEKTRKISVQMIEKYVPMVREALEEVQPYYKDQKEYDVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A256YAL9|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon ex4484_58|TrEMBL
MLIFIGTGLSIKHLTIEAISYIIRADKIYIDTYTNLVPDFSYKILSSILRDKEIVYAKRR
DLEGENIRRIIEEARHRDIAIIVPGDPFIATTHDAIRVEALKNNVEVVVVNGLSIYSLAA
SRTGLQAYRFGKTVTLVYPRLSKPYSVIEAIYDNLSRDLHTLVLLEISVEENKYMTIDEA
VNILLEIDDKNMIGDTLGVGLARIGLDDEYIVADKISKLPDYTYPPPPHSLIVIAKPHPV
ELENLKYTCGLPYDLYVKYSRSKSYP
>A0A532TQU0|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon B3_Hades|TrEMBL
MLVFIGLGLHGGGISLRGLREAQESDVVYAELYTSMLPKLRLDELEQTIGRPIKVVDRET
VEQRPDEILQAANASKVAFLVPGDPMVATTHVDLRLRATKAGIETKIIHAASIASAAAGL
AGLQSYKFGRTATVPFPDNPSQVPYETLVENRRRGIHTLLLLDIRANEGRAMLASEAIEI
MLGLEKKLQKNAFTPDTLVVVVARADSNDAIVKADKVRRLQKLDFGSPPHVLIVPGKLHF
VEAEALRAFAGAPEDVIK
>A0A0E3SF19|diphthine synthase|EC 2.1.1.98|Methanosarcina barkeri 3|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIRVADLVYAEFYTSCLMGTNLEKMEELYGKKVFLLSRE
DVEQHPDWLYKAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDIIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIIRGAAAVGIARAGSEKPTVKADYAENLKDFNFGKPLHILVIP
GKLHFLEAEALVKLAGGPIGFMEEVE
>A0A843LXX9|diphthine synthase|EC 2.1.1.98|Methanocorpusculum sp|TrEMBL
MLTFVGLGLFDEQDVSLRGAEAIRSADTVFLEGYTSVLMGASVEKLEAFYGKKITLLGRE
DVEVHPEQILEAAQNGNAVFLTGGDSMVATTHADIRIRCEDAGIPTKIIHGASITTAVCG
LSGLQNYRFGKSASVPFPYGKWFPMTPIEVISENRERNLHTLVFLDIQRDKERYMKISEA
VALLEEQGARNGVTIPLFIGIARAGSATPAVHAGDAEEMKTFDFGGPLHILIVPAELHDM
EREYLERFAGLKTR
>A0A7T3FZI6|diphthine synthase|EC 2.1.1.98|Halosimplex litoreum|TrEMBL
MLTFVGLGLYDERSVTVAGREAIRAADRVVAEFYTSTLAGATLADLEAAHDTEIEVRDRA
GVEQSPDDILDDAVDSEVVFCTAGDTMISTTHTDLRLRAHDRGIETRVVHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHAGDDLPESIIDTIERNRDRGLHTLVFLDIDGENEAYMRA
DRAAGRLADAYEDTLGVAVARAGSPDPVVRADRLSVLAEASFGDPLHLLVIPGDLHLMER
DALAALGDAPNEALEALVV
>A0A0P0N299|diphthine synthase|EC 2.1.1.98|Pyrodictium delaneyi|TrEMBL
MALYIVGAGVSSEYLTLKAIQVIGAADKVYLDTYTSIAPGVDRELVRRLNPRAEVVEAPR
RLLEDEAGKLIQEAREKTVVLLVPGDPLHATTHIALFIEARRRGVEAHVVPGVSGLQAVI
DATGLQVYRFGKTVTLVYPEEGFKPYSTVETIWANRERGLHTLVLLDLRLDAGHAMTIPE
AIRILLELEAELAAEEGREPEIRGAVVVGVARAGTSEQRCIAGTVEEVAAASYPPPPHSL
VVAAPRLHPVEEEALEVLCGCKTCREKGKA
>A0A0W8F444|diphthine synthase|EC 2.1.1.98|hydrocarbon metagenome|TrEMBL
MLTFVGLGLYDLDDISVRGLACIRNADHVFLEYYTSRLAGCTLEAMESFYGRPVQVLSRT
DVEVDPGTMLSHAAASDVVFLTGGDPMVSTTHIDLRIRAHQQGIPTRIIHASSISTAVCG
LTGLQNYRFGRSCSLPFPHGTWFPTTPIEVVGANRARDLHTLVYLDIQEERCMTIPQAVG
LLEELGAKTGTSVPLYVGVARAGAECPVVRAGSALTLAATDFGPPLHILVIPATLHVMER
EYLEIFGGL
>A0A7K3Z512|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon|TrEMBL
MNELVFVGLGLNDEKGITVKGLEETKTANTVFMETYTSLMPEFSLENFKSLCKKEIHVIN
RQDLEEDNGKKILQAAKKGKTVFLVPGDPLIATTHITLRIDAEKQRIKTRIIHGISIISA
IVSLSGLHNYKFGKTVTIPFAENFSETPYNVIAQNKQTGLHTLCLLDLKADTNQYLSINQ
AIKSLKTIESKKKMGIISESTVALGIARAGNDNPTVKAGYIVDLENFDFGEPPYSLIIPG
DLHFMEVDALIACANAPENLRRNIK
>A0A830EHQ7|diphthine synthase|EC 2.1.1.98|Vulcanisaeta souniana JCM 11219|TrEMBL
MDSQRPTLYIVGLGLGPRSITREALEVLKTVDAVFMETYTSKAPIGFMEYIRGIRNDVDF
VSREELEDNNGEVLIRELNNGRNTALLVIGDPMIATTHAAIAVIARKHGFNVRVVSSVSI
VCALLSQLGLSPYKLGPVVTVTYPRMGVLSMRAYEVLSDNVRRGLHTILLLDIRDNGDFM
SAPDAINVLREMERVGGLGVINDELMVIYAARVGWDDQRIDVSTIGNVPSIGDTPHVLVV
PGLLNPVEIDYLVNVLNANEELVHKHQLLIKRFINKSPV
>A0A2G9N993|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_32_24|TrEMBL
MTLYIIGLGLNGPKDITMKGLELVKSCDEVYLERYTSLLQCSFHDLAKFYDKEITLADRN
TSEQGMEKIVKQAKTENVAFLVIGDPFSATTHTAIFKMAKENDVNVEVIHNSSILTAIGQ
TGLQLYKFGKTTSIPFLDDFPQLETPYRILQQNQEIGAHTLMLLDIRVDQDQFMTVSQAI
EILENIESRIGEKAINDEILAIGCARLGCDDFIIKTGTLKHLKDIDFGKPLHCLIIPGKM
HFSEEEIIKMWT
>A0A031LNY7|diphthine synthase|EC 2.1.1.98|Candidatus Acidianus copahuensis|TrEMBL
MGDLYLIGLGLSKRFLTNASIESMKRSDVIFLDSYTSLSCDLSKDVLEEIIGKQISIVKR
EDLEQGYRNIIESLKTKNVAIATVGDPMIATTHVGLAVEARKNGYNVRIVPGISVHCYII
SKSMLSSYKFGRSVTLVYPYEGKTDMTTYNVIKSNQEAGLHSIIYLDLRDGKPMDGNEAI
NLLLSMESQRNEGVIRLDDVLVLGERLGCDEERVFALSFREAIKVNLNRPPYIIIIPSKK
LHYMEVEALKCLH
>A0A497RN43|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYLIGLGIYDEKDISLKGLETLRNCDELYAEFYTNVFSGDLKNLESLVKKKIKILRRSD
IEENPEENVLKNSLKKKVALLVSGDPMVATTHIDLILRAKKLGIGYKIIHASSVYSAIGE
TGLQIYKFGRTSTLAFPEKGYFPTTPYDVLKENLKAGLHTLLLLDVRSEKERFMTVNEGI
DLLLKMEEMKKEKIFNEDSLCMGIARLGNDTKIKVGKAKELLNEDFGKPPHILIIPGKLH
FMEEEAIEVFR
>A0A7D5CEA6|diphthine synthase|EC 2.1.1.98|Halolamina sp. CBA1230|TrEMBL
MLTFIGLGLYDERSITVAGTEALADADRAFAEFYTSRLVGTSVAELEAYHDTEIEVRDRA
GVERDPEPILDAAAEEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVSAQSAAAG
LTGLQNYRFGKATTLPFPSAHGGGDVPDSVIETIEANRERDLHTLVYLDIKVDDPTADAA
GLGADERFMTGDFAAKLLAANWADELAVVVARAGSDEPVVAADRLSELADREFGGPLHLL
VVPAEPHHLEAEALASLAGAPDELLDET
>A0A498GW23|diphthine synthase|EC 2.1.1.98|Methanoculleus taiwanensis|TrEMBL
MLTFVGLGLFDLKDISVKGLDAVRRAEYVYLESYTSRMMGSSVSEMEAVFGKEIVLLGRE
DVEQHPDEVIRRARDGDVVFLTGGDPMVSTTHADLRIRAAGMGVATSIIHASSIASAVCG
LAGLQNYRFGKSCSVPFPAKSWFPTTPLETIRQNLALNLHTLVYLDIQPDRYMRVGEAIA
IIERMAEILETPAPSLYVGIARAGSEHPHVAAGTGELLKSVDFGPPLHILVVPADLHPVE
HEYLRTFAGL
>A0A7J4LAW7|diphthine synthase|EC 2.1.1.98|Halobacteria archaeon|TrEMBL
MLIFVGLGLYDEKDISIKGLEAIQKSEKVFAEFYTSKLLGTTLKRLEEFYGKDIELLDRE
GIEIKSDKVIDIAKDKDVSLLCAGDPMIATTHIDLRIRAEDACVKTRIIHGASIQTAAIG
LSGLQNYKFGRSTTIPHPYKGIIAESPYDVFKNNLNNNMHTLFLLDISDDPMTINDGLDI
LSKIADKRDDYNFKDNLCVGIARAGSEHPVVKAGFIKDILDYDFGLPLHTFILPTKLHFM
EAEALVKFADAPKEILTDKK
>A0A0W1R932|diphthine synthase|EC 2.1.1.98|Haloprofundus marisrubri|TrEMBL
MLTFIGLGLYDEQSITVEGREALRSADRAFAEFYTSKLIGTTVDALSKHHGVDVEVRDRA
GVEQDADEILDAAEEGETVFLTAGDTMISTTHVDLRLRAHERGIETEIVHGVTAQSAASG
LTGLQNYRFGKATTLPFPYAHGADGTPQSVIDTIEDNRERGLHTLVYLDIKVGYERAGVD
AADEYMTADFAAREFARDWDEDALGVVVARAGSPEPVVAADRLSALSEREFGDPLQMLIV
PAELHDLEAEALEAFGEAPADVIEDNLY
>A0A1J5J7X2|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum sp. CG2_30_32_3053|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>A0A497J9T5|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLIFIGLGLNDDGISLRGLREAKNADTVYMELYTSYIPGFDRDKLEQEIGKPIQLVDRKK
VEIFPDEILNNAKTQKVAFLVPGDPMIATTHVDLRLRAAKSNIETKLIHAASIISSAAGA
AGLQSYKFGPSATIPFSDNPSIRPYEVLEENLSRGLHTLLLLDIRAEEKRLMSANEGIKV
MLALEERLRKNIFTPNTLGVVVARVGTHDNLVVANTVEKLIKTNFGSPPHALIIPGKLHF
MESEALRVFAGAPEEALK
>A0A6C0UPS8|diphthine synthase|EC 2.1.1.98|Haloferax alexandrinus|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLESNRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A6B9Y6A8|diphthine synthase|EC 2.1.1.98|haloarchaeon 3A1-DGR|TrEMBL
MLTFIGLGLHDERSITVEGRDALRAADRAFAEFYTSRLVGANLADLEDYHETTIEVRDRA
GVEQDPEPILAAAESGDAAFLTAGDTMVSTTHTDLRLRAEDRGIDTRVIHGVTAQSAASS
LTGLQNYRFGKAATLPFPYAHGGDGVPDSVIGTIEANRERGLHTIVYLDIKVGTGPRGPD
PDHEEYMTADRAAALLADDWADVLGVVVARAGSPDAVVAADRLSALADRSFGDPLHLLVI
PGDLHHVEADALAGLADAPADLLP
>A0A497LFG2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MPGSLTFIGLGLHDEKGITLKGLEAARRADVVFLELYTSLMPGLSLSRLEELVGKPIRLV
DRRVLEDQDAEPLIEEALGGRDVALLVPGDPMVATTHVAVRLRAERLGIRTAVVHAPSII
SAVVGLTGLQAYKFGRTTTITYPEKGLLSEVPYRVIAENKARGLHTLCLLDARAEEGRFM
TVREALEVMLELEEELGEGLLGPGTLAVGVARAGSEKPVVKAGTVEELMDYDFGPPPHTL
IFPGELHFLEAEALKVLAGASDQALAPGKAVRPRSIEGEAREKAEKYVANLDFAFSTLEV
HGPGPVGPEALNHVLDLAKRYHEDARRFLEAGKPLTSVAAASYAEGLIDALRLLGLVDFR
WPS
>A0A1I6GXP9|diphthine synthase|EC 2.1.1.98|Halogeometricum limi|TrEMBL
MLTFIGLGLYDERSITVEGRDALADADRAYAEFYTSHLVGATVEDLEAYHDIDIDVRDRA
GVEQHPEDILDAAEDEHVVFLTAGDTMISTTHVDLRLRAVERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPKSVTESIEANRERGLHTLVYLDIKVGDTPTSSR
NAERFGDKSDDDEYMTGDYAAEMLAEGWEDVLGVVVARAGGENPVVAADRLSALADREFG
DPLHMLVIPGDVHHVEADALRTLGGAPDDVLAENEV
>A0A7C2LMF7|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLVLIGLGLYSEKDITLKGLEEARGSDYIFAEFYTSVMPGLNLKRMEKIIGRKVKLLSRS
DIEEEGEKVILERAKKSKVSLLVAGDALISTTHVHLLLDARELEIEVRVVNNASIYSAAP
SLAGLHNYKFGRSASIARPEERFFSETPYTTVKANMNMGLHTMLFLDIKVEKSGTYLMHA
KEAIEILLKLEDRKKEGVITPETIAVVVSRAGAPEFKLKAGSIGKLLEEDLGRPPHTLII
PAELHFMEEEFLRAFASFPEE
>A0A7C4X3C8|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MARPGIGPPMGELVFIGLGLHDEKGITLRGLEEARGCDHLFAEFYTSALVGTKIQSIEAL
LEKRVTILSREDVERGSALLDAARARRVGFLVPGDPMVATTHVDLRLRAAEAGIPTRIVH
GVSIQSAAAGVLGLQAYKFGRTTTVPFPAPGFHPTSPLEVILENRRAGLHTLVLLDLQED
GTFLPPHAALRQLLEASSSLGAEAFGPTTVVCVVSRVGSSDVRAIAAPVAELLDRDLGPP
LHCLVVPGALHFLEKKALVAFAGAPRDV
>A0A7C1PTB9|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MFAEFYTSRLSGTTLEKLEGVLEKKITVLSRSEVESGDVILKAAETGKTGFLVPGDPLIS
TTHIALRIDAKQRGIETRVVHNTSINSAAPGLSGLFNYKFGASSSIPFPSEGYRPDSFYH
VASENKKRGLHTLLFLDIKDRLMTVNEALKILLDIERDKGLNVARNDSIVVGLGCVGSET
PVFIAGRINDLISRDFGPVPHVLIMPGELHFMEEEYLKEFGGL
>A0A832ZNE9|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
RAERKVLEEGAAELVEEARKKDVAVVTFGDPLAATTHVALTLTAEKKGVSWKYVPGVSVL
TYVPSRLGLEHYKFGWTVTVPEQWAHAPSFYERIRGNLKRRMHTLVLLDVGSGAMSIVEG
LEALLHWAERLGRGWDKVVGVARAGHRDEKIVYGYPEELMETEWPEPPHSIVVPGKLHPV
EEEALGRFVRGKR
>A0A534LZ83|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLHDEKGITLRGLDEARSADVVFAEFYTSGLADATVASVERLVGKKIRVLS
RTDVEDGRMILEAAAKQKVAFLVVGDPMAATTHVDLRLRAASAKIPTRIVHGVSILTAAA
GALGLQAYKFGRTTTVPFPAAGFGPTSPLEAILENRRAGLHSLVLLDLREDGSFLTPQDA
IALLLRMAVKMGTPDFGPETLACVLSRVGSPEVRATGGPIGTLSDRDLGPPLHCIVIPGR
LHFLEKEALIAFAGAPHDL
>A0A7J2KWD3|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MMLVLIGLGLYSEKDITLMGLEEARSSDYIFAE
>A0A7K4B899|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFIGLGLFDSGDISVKGQRAIFEADIVFLESYTSILTGTSNEELEKIYGKPVRVLKRE
DVEQNPEPILLAAQNGNTVFLTGGDPMVSTTHTDLRIRARNMDIETRIIHGSSIVSAVCG
LSGLQNYRFGKSCSIPYPAKNWFPRTPLDTILSNLIQNLHTLVYLDIQETRFMSVQEGIS
ILEQLGTNDSEQINMFVGIARAGSEKPVVVAGTGEKLKTIDFGPPLHILIVPALLHDIEL
EYLTLFAGYEPS
>A0A7L4QP70|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLYDLGDIPLKGLECIRKADYVFLESYTSRLSGASVDEMAKYYGREIRMLSRE
EVEVDPEPVLGLAEEFQVAFLTGGDPMVSTTHIDLRMRASRRGITTNIIHASSISTAVCG
LSGLQNYRFGKSCSLPYPHRAWMPLTPAGVIRANRERDLHTLVYLDIREECCMTIPEAVN
LLEDMSERSGFSIPLYVGVARAGSESPVVAAGDASRMREIDFGPPLHILIVPAELHVMEK
EYLEMFAGL
>A0A7J4ITU9|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MLCLVGIGLTPKHLTLEAIDTLKECKRVYIESYTSSYAEGTISELELRLNKKISALKRKE
VEEGIRELLIEAKKENIALVVFGNPLTATTHVQIILDAKKAGVKTKVVAGISVTNYLAKT
GLDEYRFGRTCTVVAPKENFSPESFYGVIEKNLNAGLHTLCLLEITEEGKLMSIREAIEV
LEGIQKKKKNKAIDRALLVALSAAGSSKEEIVAGKAEKLKKHKFNGMPQSLIVCGKLNEK
EREAIGELNE
>A0A2R6KBK1|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_8_65_32|TrEMBL
MLTFVGLGLYDERSITIEGRDVLNKADRVFAEFYTSKLAGATTADVEAFHGVDIEVRDRE
GTERDPDPILDAARGSDAAFLVAGDPMISTTHVDLRLRAVDRGIDTQVVHGTTAQTAASS
LTGLQNYRFGKATTLPFAYGSDNVPESVLTTIANNRERGLHTLCYLDIDAEREAYMSVDD
AARRLAGALDSTGTADAVSDVSDTTDADGDGAGVDFDADGNTLAVAIARAGSSAPVIRAD
RLSALAEDDFGEPLHLLVIPGDLHYAEAETLRTLAGAPTDLLPS
>A0A0U5H1T4|diphthine synthase|EC 2.1.1.98|Halobacterium hubeiense|TrEMBL
MLTFVGLGLYDERSVTVAGADAIAAADRAFAEFYTSKLVGADVADLEAYHDTDVEVRDRA
GVEQDPEPILAAAESGDCVFLTAGDTMISTTHVDLRLRAEERGIDTRVIHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADGVPSSVVETVEDNRQRGLHTLCYLDIKVDHPRVDGD
EYMTASHAAGLLAEHWDADALGVVVARAGAPDATVRADRLGALAEMDFGEPLHLLVIPGD
LHHVETDALAGLADAPADALDEYRD
>A0A1D2X0Y8|diphthine synthase|EC 2.1.1.98|Methanosphaera sp. WGK6|TrEMBL
MLYFVGLGLFSEDDISYKGFKALQSVDCIYAEFYTAKLMGGNIDNLIEKLDVPFVTLKRE
DVEDQNIIIREAMTKNIAFVTAGDSLMATTHTELYVEALNKGIETRIIHGSSIFSAAPGL
VGLQAYKFGKTTTVPFPDENFFPHSPYDAIKLNSEVGLHTLVLLDIQAHKDKYMSVNEAI
DYLRRVESERGEHVFDDDRIVIGLAQAGSDSPIVKGGTVAQVADFDFGEPLHCMIVPGNL
HFIEAEALLTLADVDKSLLEEFL
>A0A2Z2M8V2|diphthine synthase|EC 2.1.1.98|Thermococcus profundus|TrEMBL
MAIYFIGLGLYDEKDVTLKGLEAAKKCEEVFAEFYTSLLAGTTIEKIEELIGKPIKRLSR
EDVELNFERIVLREAKDKDVAFLTAGDPMVATTHADLRIRAKKAGIESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENKERSLHTLLFLDIKADQNRYMTANE
AMEILLQVEEMKGQGVFTPETLVVVLARAGSLNPTLKAGYVRDMLKEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPKEILEEV
>A0A843HZT4|diphthine synthase|EC 2.1.1.98|Sulfolobus sp|TrEMBL
MGKLYLVGLGLSRNHITNIAINSLKNADIIYFDAYTSYSCDIDSDYLSGLLNKKVFNAER
SLLENESKKIVDVLNAGKSVAIAVIGDPMIATTHVSLILEARKAGHEVDIVPGVSVYCYF
ISKSMLPIYKFGKSSTIVKPVGDYIDPGFYYVLEENRARDLHTLFFLEPDLTASYALQIL
LNLEEKFKHNVIKEDDLAVIGSRLGCDDEEVFSLTIKEAINLNLKNPPHITIIPSRKLHY
IEEEALKCLMKR
>A0A133VCS2|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA261G05|TrEMBL
MLIFIGLGLQEKGLTLEGLEEAQNADRTYAELYTSLIPDLDLDALSEKIGKKIKVLERED
VEEHPDEILETAKSEKVAFLVPGDPMVATTHVDLRLRAEKAGIETRIIHGASIEIAAPGL
AGLQSYKFGRSATIPLPEKPSETPYEVLVQNQEDGLHTLLLLDIEAPEERYLTASEAMEI
MLDLESKGGKNVFTQETLVAVIARAGSEKPTVKAGKVGDLIDFDFGSPPHVLIVPGKLHF
LEAEALQVFGGAPEEVEGYVE
>A0A5C0SNM1|diphthine synthase|EC 2.1.1.98|Thermococcus aciditolerans|TrEMBL
MAIYFIGLGLYDERDITLKGLEVARKCDLVFAEFYTSLLAGTTLDRVEELIGKPIRRLSR
EEVELHFERIVLSEAKERDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMLKEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A2D6W2W0|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MTLYFIGIGLNDEKDITVKGLELVKKADIVYLENYTSKINCNIKYLEDLYGKKIILADRK
LVEIDADKTILENAKTKEVAFLVVGDVFSATTHTDLYIRARNMAIKTRVINNASVLTVVS
ITGLQLYKFGKTPSIPFENENVETPYDILKLNQKNNLHTLFILDLNPDTNNSMAVNDAIR
YLLKVELKRGENVFKDSTLCIGCAKLGSLDQIIKAGKAKDLLKTDFKNGMQCLIVPAKNL
HFMEEEAIKLYY
>A0A7J9PYP2|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLVFIGLGLFDEKDVTVKGFEEAKKCDMVFAEFYTARLMGSSKEKLESLFGKEIKILNRK
EVEDGRIILDEAKNKNVAFLTPGDPMTATTHVALRIQAKEMGIKTKIVHGVSIVSAASGL
LGLQSYKFGRTTTIPFPEKDYLPESPYEVIRQNKENGLHTLI
>A0A662W9W0|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon|TrEMBL
MLVFIGMGLWDERDISLKGLEEARRADEVYIEFYTSKLIGTNLEKIENLLGREIKVLERS
DLEENSRVLVREAKAKNVAILVPGDPMVATTHSALKLEAEREGVKTKIIHGASILSAVCG
LTGLHNYRFGKSATVSYPYGKPSATPVNVVKANWSIDAHTLLYLDLHPEPMLIPTAVEIL
RKAGLENCFAVGIARAGSEEPAVKCDFLEELCQYDFGEGLHVIVVLAKTLHFMEYECLRT
FASAPSALEKLVR
>A0A7L4RG44|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLLLVGMGIWDESDISLRGLEELKDCDVIFAEQYTGSREESSLKRLEKLAGKKIILLGRE
EVEGEEKILKEALSKKVALLVPGDPLISTTHISLKLSAEKNGIETAVVHSSSILTAAIGE
CGLQAYKLGKPCTLAIWSKGYEPTSSYDVIAENRERGLHSVVFLDIKERCMEASEALQQL
LKIEKEKKRLGEFHAVVLSRVGSREQKITYGKPEELLQKKLGKPPFILVIPGKLHFMEEE
ALKHFICP
>A0A842SWX7|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MAKPTSSAREASGSASPLTAGGYPAGAFRKYKPFFLILIMKFVLIGSGVGFDLTVSGVEE
LKSCDEAYIETYTNPLDRKEINLLENKIGKKIAVLERGQVEGRFLLDRAASADVCLIASG
DPLTATTHITLVMEARERKIPVKVIHNSSVYSAAPAKSGLQIYRFGKTATLVNPRPNYQP
KSSLDAIRSNLENNTHSLVLLDTEPKPMEAKNALEMLSEFETAVVLSRLGSDDEKISYGK
IKDLKELELGRPPFTIVIPAGLHPVEQEFLDTL
>A0A662G715|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MIYLVKLYLIRVSLRVSNLGELIFMGLGLSGIKDISLKGFEILKSADYIFIELYTSIIPG
FSIERFEKLINRKIRRVYRRDLEDLSGKEILSLAEKHRVVLLVPGDPFIATTHNSIRLMA
IDRGISVKTIHASSIISAIYGSIGLHCYKFGKIVTIVFPDERYGYFPETPYHVLHQNLSN
NLHTLFLLDIRVDEKKYMTIGEAIKILLELENKIGRKIISLKTIGIGVARIGSEDEKIVC
NTLGKLLEMDFGQPPYSLIIPGKLHPMEIESLIKLAGADKRLFGGEYEGKNIA
>A0A6B1I069|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0669_bin_11|TrEMBL
MLHIVGLGVSDDSIPYNIEDIIQKADIVYLEVFTSPDINTSQIRRICPTLQMAPRWLVED
GRRILEESEYKDVVLASYGDPLVATTHTELRVRAAQRGIPVNVVHGPSAITTLVGECGLH
HYMMGRMATIMSEDTLLETPYMVSYRNAVLGNHTLLLLEYNQDADFFLKADVALQRLSDA
EKSYRRGVFTPDRHCIVACRIGTKRQLVVSGSLSSLEGYDFGEPPHSIILTGRLHFTECD
AIRVLTRCMDGPPENQTIKSIPQQMIEKYTPMIHKSIQDLPDCSNNEKLIVQNAISYIQD
AQRALESGQDEVAILSIGYADGLVDALRISHGMDPKI
>A0A1Q9P135|diphthine synthase|EC 2.1.1.98|Candidatus Heimdallarchaeota archaeon LC_3|TrEMBL
MRGKFFLIGYGLSGPDGLTLHALNVLKSVDIIFFEIYTNFPFEDSLKDLENVLQKKIIPI
SRTRVEDESTEFLKAIKNNNVALLISGDPFIATTHHSLWLEASNLEIDVEVINNISIYNL
VPSLTGLSAYKFGKISSITFPDNFSVAPYDTLQKNLDINAHTLFLLDIEINSNKFLEINK
ALDLLLKMEQRQSNKLITEDTLLIGLAHIGTNKSKIVFDSLKNQQKIDWKSIGPPQAIVI
PGNLHFAEEEILNKFWGKEGSNPVYYKKSAEKIVVTGSFDIIHPGHIQFFHEAKKQNPNA
ELIVVIARDSSIREFKDRDPILPEDHRLQVLRSLQIVDKAVLGNEGKDKIKIIEEIDPDL
IVLGYDQWISEEKLISELNKRELKTKVVRLKKYGNSLASSTEIRKKIGREFSNKTNNQKK
TQ
>A0A5E4LME2|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLSLIGMGLWTIGDLPLRAAWELRKCDEVYAEQYTSAMQAGLLSQLQGKIGKSRIRVLSR
AEVEKGEVLLKAAEKKRVALLIPGDPLIATTHISLLLEAKKRGIKTQIIHASSIFTAAIG
EAGLQVYKFGRTVTLAKWQPAYEPMSAYDYLGENLARKLHTLLLIDIDEGRPLSQAEIFD
LLAKMEKRGGKGIFAPKRELVVLSAVGSANQRVSYGPIEKLEKAKLGKPPFTIIVPGELH
FMEKEALEAFSN
>A0A5E4KSX7|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLTFIGLGLFDEKDITVKGLEAVKKADMVYAEFYTSHLMGTTIGKIEEFFGRKVNVLARE
DVEQDTSWLTHAKDKNVVFLSGGDAMVATTHIDLRLRAKDRGIDTAIIHAPSISSAVSGL
SGLQNYRFGKSTTVPFPYTRGDKKIISEAPYDTIRMNKKNDLHTLVFLDIDMEKGFMDIR
TAISILLEMEERKGEGILMHTLAVGIARAGSDSPSVHADYIDKLKNHDFGEPLHSLVIPA
SLHFIEAEALVKLCGAPSEIMK
>A0A5E4JHZ6|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MFYLIGLGIYGWKGLSVEGLNACKNADSMFIETYTNIIQKEYIIDLEKTINKKIRELSRD
DVETKSEELFIDKSKKSDVCLLVGGDPLTATTHIELLRLCKEKGIKFKVVHAASIYNSVC
ETGLHVYKFGKSCSIPFPEPHYNPTSFFDIIEQNQKIEAHTIVFLDIKKDQDKYMTISEG
LNILLNISKEKKSFFNDNTKVIGIARLGSPDQVIRYGSVKELLNFDFGKNPHILIVPKMG
KIEEEYAKELYS
>A0A5E4K2Q5|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGLGLNESGISQQGLEALKKCKKIYLENYTVNFPYDFKKLEEVIGKKVILADRNFV
ESDKLVKEAKKEDIVLLVYGSPLTATTHISLIEEARKEKVKYEIIYSASIFDAIAETGLQ
IYKFGKIASMPAWKKSFEPTSFMEIVKDNEKIKAHSLILVDISLDLKDALYELEESVKKE
DIKLGKIVVCSRLGTKDKKIVYGELKNFKADIAKPYCIIIPSKLHFVEEEVLESFANKKL
>A0A5E4I7B0|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLVSLGLHDEKDISLRGIEALKKSDKVFMETYTSSIKPDMSSLEALIWRKIIVVDRRA
VEEECVILESAKNCNTAFIVPGDALSATTHQQIVFEARKLGIPVEVIHGSSIFSAVAETG
LSLYKFGMTVSLPKPQEHYFPMSPYENIFENKKRGLHTLILLDIGMNAKEAVEILLELEK
KAGKNLFSDSTKLVVVAHLGQNSAIKYGTITDLKKEELYNLPHTLILPGDLHFSENEFLS
QFKI
>A0A2R7Y7B2|diphthine synthase|EC 2.1.1.98|Zestosphaera tikiterensis|TrEMBL
MPGKFYIVGAGLSADLISLKAVKILKNVDLIFIDMYTSILLGDAEELKKYIGAKEFIPLR
RSDVEEKPHETIFKHIESGLNVAFLVPGNPLDATTHASLVVEAWKKGIDFEIIPAPGIIP
NAVSMSGLMVYKVGKVVTLTFPKHGIYSEYPYDVIKDNDLRNLHTLLLLDLDLENNKVMQ
VSEAVDLLYQLENLRREGVISPRRLGIAVSGLGGPKQRICFDTLEKLRGLPNHDGPNTLI
ITSPKLHFMEEEVAKVISNVYCR
>A0A396J362|diphthine synthase|EC 2.1.1.98|Medicago truncatula|TrEMBL
MEAYTSLPSFGLSSYGLSNLEKLYGKPITLADREMVEEKADDILSQAQLSHADFLVGATT
THTDLVVRAKKMGIEVKVVHNASVMNAIGICSYIVMVCSYIVMGELFQYLSLRRRGDLIA
SIYEKIQQSLYLGLHTLCLLD
>A0A842KYF5|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MDKILDEAEMKNVCLAVLGDPLFATTHLTLILECRKRNISYKVIHNTSIISILMNSFGLH
PYKFGKIATIVRKSGTPATTVYFTLYENLVKKLHTIFLLEYDIESKEGVKPNDAFNILKE
AEEVYKLGAFSSETFVIVACRVHREDEKIYMGRVKELLEIDFGQPPYSLIIPSELHFMER
EALSVLFGLEKRNEINNSKMIKKKVEYLVYKYVGNTRKALEDARKRLPRKEFDSLFENVE
CYLDDAIRFLNLGEENLAMLCVGYAEGLLDALRFQGILELKW
>A0A8J8PWK1|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. A20-N-G8|TrEMBL
MGVLNLVGLGLAKKFITKSAVDALLNSDFIFFDRYTSKSCDINTDSLKEILNGKDVIEAN
RDLLENNSKIMLNYLDNNYKVSIATIGDALIATTHVSLALDARKRGHIVNVIPAVSVHCY
IVSKSFLSSYKFGKSVTVTFPYDNFIDYGPYHVIRDNKERGLHTIIYLDLKDGKAMTAND
ALNILLSMEDKHRMNVISKSNIVIVGARLGCENEKVIAMTVEEALNYDFGDTPHIIIIPG
TLHYMEADAIKWMLMT
>A0A147JYB4|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon DG-33-1|TrEMBL
MLIFIGLGLHGEGISLLGLREAQKADIVYAELYTSLVVGLDLKGLEQEIGKPVQVVYRET
VEQRPDDILNAAKVGKVAFLVPGDPMVATTHVDLRLRAARAGIQTKIVHGASIGSAAAGL
AGLQSYKFGRSATVSFPDNPSQVPYETLVENRERGLHTLLLLDIRAKEGRAMLSSEAIEI
MLGLEKKLPKNAFTPDTLAVVVARAGSDDAIVKADKVGRLQKLDFGPPPHVLIVPGKLHF
VEAEALKVFADASEDMVQ
>A0A2R6NC44|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_9_67_24|TrEMBL
MLAFVGLGLHDERSITIEGQATLGDADRVFAEFYTSKLAGATIEDLETHHDTEIEVRDRA
GVEQDPEPILNAAERGEVAFVVAGDPMISTTHTDL
>A0A497EK53|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLIGVGLCNEKSLTIEALDAIKNCDEVFLENYTSILQCSKEALEKITGKRIMLANRKL
VESHELIKKAKEKNIALLIIGDVFSATTHITLFLEAKKQNVEIRVMHNASILTAIGITGL
ELYKFGRTASIPFHETDYPIEVLKQNQQFGLHTLFLLDLDPGNNRFLTIAEACDYLIKKG
ILPKTKALGCARIGCFDHKIVYAELDKLRSVDFGKPPYCLVIPGKLHFVEEEMLSYYEIK
>A0A662FKY8|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLVGLGIGGCKAITLQGLGAVKQCDKVYLEVYTSFFDSVSELENLVGKKIFVVGRDFV
ESGDVILSEAKDNNVAFLVVGDPLCATTHWDLLRRAKENNIPVEVVHNASIVSSVGSTGL
QVYKFGKITSIPFSDSEVIVETPYNVLKENLSIGAHTLFLLDLRPDENRFMSVHDAVEHL
LKIEKLKKENLFNEDTFCIGCARIGFSDEFIKAGKARELLNVDFGRPVHCLIVPGKLHFM
EEEALRLFQ
>A0A7C4V627|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MESILLEAKDNDVCILFIGDVFAATTHTDLYLRAVNASVRVSVLHNASVVNAISSSGLEL
YRFGKIVSIPYWSKGFTPSSFLDGIASNKAAGLHTLCLLDIKTDENRFMSVNEAIAVLFE
AQTLRQEQQDLLPFLDQQSLVVGCARLGWPDQLIVAGPVSVVQKVVFGAAPHALIIPGKL
HPIEEEMLALFSPGDKS
>A0A2D5XEU5|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGIGLNDEKDISVKGFELVKKADVVYLENYTSKINCNISYLEELYGKKIVLADRK
LVEMDAEKTILENAKTKEVAFLVVGDVFSATTHMDLYLRAKKMGIKTGVVHNASVLTAVG
ITGLQLYKFGKVTSIPIDNENVETPYDVLKVNQQNNMHTLFILDLKEGSNNSLSVNDAIR
YLLKVEMKRGERVFTDNTLCVGCVKLGSLDQIIKVGKANELLRCNFKNGMHCLIVPGKMH
FMEEGSLKLYQ
>A0A2R6L1K3|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_10_66_29|TrEMBL
MLSFIGLGLYNERSITLRGRDALESADAAFAEWYTSSLAGTSVDRLEALHGIDIEVRDRA
GVEQHPEPILDAAEEGHAAFLTAGDTMISTTHVDLRLRAHERGIDTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFPETHGGVPDSVIDTIKANRDRDLHTLVYLDIDGENERFLTGDR
AADLLAEPLGNPLGVVVGQAGSDDPTVRADALSALAGESFGPPLHLLVIPAEPHPLEREA
LVELAGAPRR
>A0A7J4RC74|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MENGSMTGFALIGMGPGKVESMTLEAVEVAKNADIRLYEAYTALWPEEELLKLEAMIGPI
ERIMRPAVERPEELFKQAQSQSIALLVVGDPMQATTHIDFQLRAEKAGLPCQVIHGISVT
TLVPGSTGLSDYKFGRSTTLTYPYGDWVVTSPLEVMLRNQAQGLHTLVLFDLDPTGAGTG
DQLPMQPKDAFASITKMADKLANSERDAVFEQQIESLTNSSCVLCSDLGTNDASMKTTTI
GNLGNIPGGRLNCLVFLANMSEMELEAVNRWR
>A0A7J4RX91|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MAEDSDKPKQASLVLIGMGPNMLTSMTEEAIVAAKSADFRYYEAYTAMWPIEELERLESR
VGPIKKVMRPEVEQPEEILNLAKENTVAVLVVGDPLQATTHVDLQLQAEENGIDCRIIHG
ISITNIVTGAIGLSNYKFGRQTTLTYPYSNWIATSPLEILAMNRIMGHHTLALLDLDPTG
AGTGKQQPMRPKDAVISIGLMIEKLSSGIEDINDNDSLSKLKKQAINELVATKFADWNVV
LCSDMGAEDQSIIYTNLADLADFPGGNMNCLVFPASTSDVEEKALLRWSREEG
>A0A2R6N583|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_8_66_22|TrEMBL
MLSFIGLGLYDERSITLRGRDALESADAAFAEWYTSSLAGTSVDRLEVEQHPEPILDAAE
EGHAAFLTAGDTMISTTHVDLRLRAHERGIDTRVIHGTTAQTAASSLTGLQNYRFGKATT
LPFPETHGGVPDSVIETIEANRDRDLHTLVYLDIDGENERFLTGDRAADLLADPLGDPLG
VVVGQAGSDDPTVRADALSALAGESFGPPLHLLVIPAEPHPLERDALIELAGTPDRI
>A0A2R7Y0U4|diphthine synthase|EC 2.1.1.98|Aigarchaeota archaeon NZ13_MG1|TrEMBL
MSITFVGLGLGPKKHITEAALDSIRRADVVFLDTYTGMLPKETVDFLRKISRRLVLADRY
TLEEGAEALLRDAVEKEVVVAVQGDPFVATTHISLALEACKRGIACKTVNGISSYSAAAS
LSGLQAYKFGRAVTLPSEDSVESVRSVYENILENMSRGLHTLVFLDTKGNGLRIPVALSR
LRELEGSLKKGVVSDDRLVVALARLGYEDCVVKAGRVVELLAWDFPDPPHMLIFPGKLHF
LEREALVRLLGVPREYVEAYEPINYGVDRVRRYIDACEGALSRSRGSSREAKVTEVLRVA
ESYLEDSKFFLKSGDIFNSLSAISYCEGLLDALRMLGYVEFDWKK
>A0A6F9ZVY4|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MPGELIFIGAGLSRDDISLKALSAAKSCDVIFAEEYTSRLSDCSMKELETIIGKKINVLR
REEVEEEEIPIRHALTKKVAFVVAGDPMTATTHISLRVEAEKKGIKTRVIPGVSVYTAVP
SILGLQHYKFGRTTTLVYPEENFFPLSPYYVIKENMERGLHTLVLLDINAERNRLMTLGE
AIDILLEMENRAKEDVIKEDLLACAVARAGAGDSIAIAGTIKRLREEDLGKPPHTMVIPG
ELHFAEKEALKILCGYREM
>A0A075G8S8|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_05_G02|TrEMBL
MLWFVGLGISGTQSIPIEVVKIIQKADFVYLESFTSPIYKQQEEEIKNMVNGSFKIAKRW
LVEDGQEILKASKSSTVVLLSYGDPYVATTHIELRTRAKLEKIETNTIHSASAITSMIGE
AGLQFYKVGRIVTIMNEKKSIITPYTAIFKNLIQGLHSVILLEYNQDENYFLDPKDAISS
LLDVEKEQKRNVVNNDTFAIVASRIGFETQKITSGKFSNLLKVDFGELPHSIIITGKLHF
TESDAINVLTECLDKPSDNSSRIKSTSIQMIEKYVPMVREALEEVKPFYNNAKEFQEILQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>A0A0E3QZS7|diphthine synthase|EC 2.1.1.98|Methanosarcina barkeri 227|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADVVYAEFYTSYLMGTNLEKMEKLYGKKVFLLSRE
DVEQHPDWLSEAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGSSIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIMRGAVAVGIARAGSEKPVVKADYAEKLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAEAPAGFMNEAE
>A0A8J8Q2A0|diphthine synthase|EC 2.1.1.98|Natronococcus pandeyae|TrEMBL
MLTFIGLGLYDERSITVEGQEALRAADHVYAEFYTSKLLGATVEKLESTHDVTIEVRDRA
GVEQHPDDILETAEREDVAFLTAGDTMISTTHVDLRLRAHDRDIETRVIHGVTAQTAASA
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIDDNRADGLHTVVYLDIKVGHNPPDRQ
NATRSDEKADRDEYMTADVGADLLAEVYPDLVGVVVARAGSPDPLVAAGAMSDLAERSFG
DPLHLLVIPGECHLLEADALVELGGADRDALDVV
>A0A8J8E7W7|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 9N3|TrEMBL
MALYFIGLGLYDEKDITLKGLETARKCEKVFAEFYTSLLAGTTIDKVEELIGKPIVRLSR
EDVELNFEKIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AVTGLQIYKFGKSTTVAYPEKNWFPTSHYDVIRENRERGLHTLLFLDIKAEQNRYMTANE
AMEILLQVEEMKKEGVFTPETLVVVLARAGSLNPTIKAGYVKDMINEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEEILKEV
>A0A843KFS5|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon|TrEMBL
MGELIFVGLGLGGVDDLSARAVRALQDCDQVFGEFYTSKLIDSTPDDLERAIGKSIVRLK
RREVEEEETVIDAARNGKVAFVTAGDTMAATTHVDLKIRAMEEGITTTVLYGVSIFTACA
SALGLQPYKFGRAVTIPFPEPGYTPLSPFENIYENWSRGLHTLVLLDIREEEGRYMTANQ
AVQWLIDAEKAKGLGMIDERTIICAAARVGSRTEKVSAGYPSKMLDEEMGPPLHAVVVPG
KLHFVEAYALVKFAGAPEEIADDQNL
>A0A5Q0ULN9|diphthine synthase|EC 2.1.1.98|Halomicrobium sp. LC1Hm|TrEMBL
MLTFVGLGLYDERSITVEGKEALQTATDIYAEFYTSKLIGTTIQKLEYYHDIDVEVLDRA
AVEQTPDKLLDAAEDGDVAFVTAGDTMVSTTHVDLRLRAEERGIHTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVETITANQERGLHTLVYLDIKVDDPHWEGE
QEFMTADHAAGLLADHLDTLGVVVARAGSANPVVEADSLDALADGDYGGPLHLLVVPADL
HEMERDALTTLADAPLDG
>A0A832ZMU9|diphthine synthase|EC 2.1.1.98|Pyrodictium sp|TrEMBL
MLYLVGFGPSARFLSIAALQALAHADKVYVDVYTSFAEGFSLELVKSLAPSAEVVEASRK
ILEDLSHKIVDEAKRANVVVLVAGDPLTATTHNALRLEALKQGVKVEVIPAVSGVQLAIA
VTGLSWYRFGRPITLVYPEEHYKPYSTIEVIVDNLERGLHTLVLLDFRVDQGKIMDVKTA
VKLLFELARELNGKDFLERLREAIMVGIARAGFRDQKCVAGYSRDILDSKFPPPPHTLIV
AHPRLHPIEEDLLKRLCGFKGSNY
>A0A7J9RC67|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MLWFVGLGISGAKSIPLEAQEVLAKADIIYLEQFTSPIGKSDLSKIKKMTKGDFRPAKRW
LVEDGNEILKNAKRNKVVLLSYGDPYIATTHIELRTRAIEEKIKTKSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALMG
LVETEKGQKRNVIDSSTYAVVASRIGFANQSIISGKISSLKKMDFGKPPHTVIITGRLHF
TESDALKILGDCLDEPTDNSEKTEKISIQMMKKYVPMVREALEEIEPHYKGQKEYQIILE
NAELYIRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGFDPKM
>A0A1N7CBA8|diphthine synthase|EC 2.1.1.98|Haloterrigena daqingensis|TrEMBL
MLTFIGLGLYDERSITVEGQEALRDADRAYAEFYTSKLIGTTVADLESTHDVDIEVRDRA
GVEQHPDDILERAETEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGITAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTNTIDDNREDGLHTVVYLDIKVGHERADED
EYMTADIGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMSDLSTREFGDPLHLLVVPGEC
HLLEADAVVALAGADRSTLDVV
>A0A7C5VD53|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLKLVGLGLGSPEYFTRAALRELEDSDVVYLDTYTGFLDERAVSELRSLLGERLVLAGRR
DLEEGSRRLVELAEKEEVSVAVPGDPLIATTHSSLLVEAARRGVSWRVVHGVSVLSAAVS
RSGLSAYRFGRTVTVPRRAGAEEYEGIYRTIASNVELGLHTLVLLDTAEGGLTAQEALRS
LLEVEASMGSEVLSRSTLITLTRIGLEGEAVVCGDVDRVMRSSLPPPPHVLIVPGKLHFA
EREFLERVLGCEAPRSRETLSPTAARARSYIEKAREVIGKLEVVSESEETKRLLELAESY
VNDAETFLRSGRSEDALVAVSYAEGIFDALRLLGLVRFEWPRGRGGSFSPREPSR
>A0A5A7S3Y8|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MPGELIFIGAGLSRDDISLKALSAAKSCDMIFAEEYTSRLSDCSMEELETIIGKKINVLR
REEVEEEEIPIEHALTKKVAFIVAGDPMTATTHISLRIEAEKKGIKTKVIPGVSIYTVVP
SILGLQHYKFGRTTTLVYPEKNFFPLSPYYVIKENMERGLHTLVLLDINAEKNRLMTVRE
AVDILLEMENRAKNNVIKEDSLACAVARAGAEDSIARAGTMKTLREENLGKPPHTMVILG
ELHFTEKEALETLCGYREM
>A0A7J4GUB5|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MILAKAKGAGGLSMTAGLILIGLGPSGISNMTRAAISAATQADIRLYEAYTALWSESALA
QLETEIGEITKVMRPEVEEPSQMLSLAKEKSVALLVVGDPLQATTHVDLQLQAQEAGIDC
EIIHGISITGLVTGAVGLSNYKFGRQTTLTYPYGGWIATSPLEVIALNRIQGLHTLCLLD
LDPTGAGTGNQKPMQPEDAQTAIMAMAKKLEDSIDEDINDSNLQRLKFEASQKIIAELND
LDVVICTDMGGKNQSISYLPLKDLHICETGGLHCLVIPAKLSEVEQKALIRWTKQ
>A0A0X3BJ08|diphthine synthase|EC 2.1.1.98|Methanoculleus bourgensis|TrEMBL
MLTFVGLGLYDLGDISLKGLECVRNADAVYLEAYTSRLMGTDVVEMEAFFENEIRVLSRE
DVEQNPRDIIERAARGRVAFLTGGDPMVSTTHADLRMRAAAAGVATSIIHASSISSAVCG
LSGLQNYRFGKSCSVPFPAKGWFPTAPVETIAANLDLNLHTLVFLDIQMDRYMRIPEAIA
IIEEMAAKRGIEPPALYVGIARAGSESPVVAAGSGAKLKETQFGPPLHVLVVPADLHPME
REYLEIFAGL
>A0A7J4R4D9|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MGNGSARFTMTAVLEGPGLWLIGLGPGDLRHMTSFALSVAEACDKRYLEGYTAILPDDQE
EKLGDLVGDWDRAMRDDIENPDQIIRQAKNVMVGIMVVGDPMQATTHIDLKIRCQESGVP
FHVVPGLSATSLAVSLSGMQSYRFGRQVTIPFPYGDYLPTSPLEIILKNYSSNLHTLVLL
DLDPTGMGLAPPEPMVPKQAYEILKAMAERYGEYEEEEYGSLSSSISDWNAILLSDIGTS
GQRVVSGSLSGISEFEGGLIHCLILPTEFSGMEKEIFESLKADM
>A0A7G9XZY7|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MLTFVGLGLYDEEDITLKGVKAIKDADMVFAEFYTSKMMGTTIERMESRYQTTITTLSRD
EIESDPAWLHHAIDRDVVLLSGGDPMVSTTHIDLRLRASDLGIATEVVHGTSIASAAAGL
AGLQNYRFGKSATIPFPYTARSKTIVSETPYNTVLLNRNNDLHTMLFLDIDPIKGFMTIS
EAAQLLMQVDERGLLDRALGIGIARAGSPDVMVKCDYLRDLAGSDFGAPMHLLIVPAGLH
QMEAEALVRFAGAPEELIER
>A0A7C4W2Y6|diphthine synthase|EC 2.1.1.98|Geoglobus ahangari|TrEMBL
MITFVGLGLWDEKDITLKGLEAVKKADKVYAEFYTSKLRAKLDSLEKLYGRKIEILRRED
LEDRCIDLLKEAKQKNIVILVAGDPFVATTHSSILIEAKKMGVPFKIIHNASIISAISGV
TGLHIYKFGKTATVSYPYKGIVSRKPLDTIKQNLSINAHTLLLLDLNPEPMRINQAVEIL
EKVDDGTLNHFAVGVARAGGDNYIKCDYFYELKHHDFGDPLHSIVFLSKTLHITEFEFLR
EFADPPKELEEIVE
>A0A7L4R3Y1|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLSFVGLGLYDLGDIPVKGLDCIRKADHVFLESYTSRLSGTSVDDMARFYGREIRVLSRE
QVEVDPDLVLGLAEEFHVVFLTGGDPMVSTTHIDLRMRASRRGIATTIIHASSISTAVCG
LSGLQNYRFGKSCSLPYPHRSWMPLTPAEVIRENRERDLHTLVYLDIQEDRCMTIPEAVD
LLETMAGKSGFSIPLYVGIARAGSESPVVAAGDAGRMKGTDFGPPLHILIIPAALHVMER
EYLEMFAGL
>A0A7J4FW28|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGIRAVRAADMVFAEFYTSKMMGTTIERMESLYRKKITVLTRD
DIEGDPAWLHHATRGDVVLLSGGDPMVSTTHVDLRLRAADLGIKTAIIHGTSIVSAVSGL
TGLQNYRFGKSATIPFPYRVRSKTIVSETPYNVIRQNRDRDLHTMLFLDIDPEHGFMTIQ
RAVELLGHIDKAGLLDDALGIGIARAGSPDVVVKCDRLLDLPAFDFGAPMHILVVPAGLH
RMEAEALVRFAGAPRVG
>A0A3N5BW11|diphthine synthase|EC 2.1.1.98|Methanobrevibacter gottschalkii DSM 11977|TrEMBL
MFYLVGLGLFDEKDISLKGLECLRNVDKIYAEFFTSRLFGSNFNAIEELVGQKIEILVRG
EVEEESKFIEEAKTQDVALIMGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEAIEENLKMDLHTLVLLDIQAHKDRYMTVNQGL
EYLMNIHDTLDRDGLINENTLAVGIARVGSKDVCVKAGTINELIDFDFGGPLHCIVIPSK
LHIVEAEYLVEIAGANSKLLDIV
>A0A662QD76|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MPLWLSVSHENLKAVNEMTIYLIGLGLGTSRQLTLEALETAKSLDKIYLDTYTSFIENSF
LEELSKELGERLVKADRRMLEEKVSDIIREAGRMEVGILIPGDPLIATTHTSIIAEAAKK
GISFKVIHGLSIYCAALSASYLHAYKFGRVTTIPKSGIGVETCYRVIAENMERGLHTLVL
LDTADGGLTIPEAIELLLRAEDKFGLGIIHGDRLVICLARIGFDDEFKWAGRLRDASQRK
YPPPPHSIIFPGELHFSEREALKAILNADAEVLDEHKPPRLWSSRIEKYLENVRRALEEM
SYLSNDITEDLVNIARSYLEDAERFWESGDLFDALAAVSYAEGLLDALRIMGKVEFTWGS
GERVINGR
>A0A7C2N6E1|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MSPGTLYIVGLGLSPRLVSLRAIEVLRSCDYVFYEEYTSIPSEGSIGDIEAIVGKRFRRL
SRRDLEDLSAKEILERLSDGKIVCLASWGDPIAATTHAYIATEVIRRGYGYSYIPGVSAV
ITALGYSGLMVYRLGRVMTLVRPRSVDEARGIYERIMEALGRGYHVLLLLEMDSEGGYYM
RVDEASRILIEISRSLGDEIRDLFGVALAGLGSKNQAICYSSLEELSKTVLEPIPQMLIL
VGNLYYTEKEYIDSMVRKHGKCWNPI
>A0A3A5USH9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MMGEGVAGFRMTVGNVLSGLWLIGIGPGNLQQMTLEAKEIATKCSKRYLEGYTAILPKDQ
ENELENIIGVWKKVMREEIENPREILDEAKKEAVCILVVGDPMQATTHVDLEMYCHDEGI
DFNIIPGLSATSLAVSMSGLQSYKFGRQVTLPYAYGNYLATSPLKLIQKNKMNNLHTLVL
FDLDPSGMGVETPQPMMPSEAIKILQKMYEKLSNEEELLDVESPLTWDGILLSDLGTKEQ
RITSGSLNELSTQDVGVIHCMVIPANFSEMEKEAFNRRRMVE
>A0A832Y533|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MLTLVGLGLGGPESLTQAGIAAIREATAVFAEGYTSPLLPETLAWVEREAGSVQLLSREV
VEQPETLLAAARDGEAVLLVGGDPLSATTHISLRLQCREAGIACRVIHNASVLTAVAGEL
GLQHYRFGPVATLVTPQGDYRPLSPVKRVLQNIEAEFHSLVLL
>A0A8J8ER88|diphthine synthase|EC 2.1.1.98|Thermococcus sp. CX2|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELHFERIVLSEAKDKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AMTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGEGVFTPDTLVVVLARAGSLTPTLKAGYVKDMLKEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPRDILDEV
>A0A8J8TD55|diphthine synthase|EC 2.1.1.98|Halonotius terrestris|TrEMBL
MLTFIGLGLYDEQSITREGEAALRAADRVFAEFYTSRLLGATVEDLESHHNTEIEVRDRA
GVEQDPEPMLRAAEDTDVAFLTAGDTMISTTHADLRVRAADRGIDTHVIHGVTAETAASG
LTGLQNYRFGKAVTLPFPAVHGAGDVPPSVIESIDANRKRGLHTLVYLDIKVDTHRDLAE
LDTDEPYMTADHAAELLAGDWADELAVVVARAGSPEPLVAADRLSALAERSFGEPLHLLV
IPGDLHHVEADALEALAGAPAALLPDEE
>A0A7J3E320|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLTLVGLGLHDEKDLTLRGIEAIRRAEKVYIELYTSKWFGDLKKLEEIAGKEIKVIERSD
LEENSERILKEAKEKNTVILVQGDPLVQTTHAALVLEAKKKGIETEIVHNSSVISAVAET
GLHAQKFGPYVTIPFPEKTKGLIPKFLIETIKENKKRGLHTLCLLDVAERCMSVKEALEI
LIKAKGLEENSEIVICSKLGSKNGVITYGRVEELMEKEFEPPSVIIIPGSLHFTEKEHLY
FFRP
>A0A835X0V9|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFVGIGLTGYDSISLETQRLLKDANYVYLEEFTSPIHKNEINKIKKLTKGQFKTVKRW
MVEDGKEILKNSKKQNVVLLSYGDPYIATTHVELRNRAILEKIKTRSIHAASSITALVGE
CGLHFYKIGRIVTIMNDFQTSKTAYYSIYENMLSGNHTVLLLEYNQEKQFFLDPKDAFMN
LLNTEKDQQRKVIEPSTFSIVASRIGFKNQKIIAGKISNLKKEKFGNPPHTIIIPGSFHF
TESDALKVLAKCKDEPTDNSSKLKKISKQMIEKYVPMVKKALEEITPYYKDSKEFQAVLE
NAELYIQDAEKFLEEGKDEVAVLSIGYADGLVDALRISKGFEPKI
>A0A835S5S3|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFVGLGLSGPDSISLETEKLLKDADVVYLENFTSPIEKSNLTKIKKLVKGEFKIGKRW
MVEDGREILKNSKTKKVVLLSYGDPYIATTHIELRTRAIQEKIKTQTIHAASSLTAIVGE
CGLHYYKVGKIVTIMKEFPTLTTVYYTIYENVLAGNHTILLLEYNQDEKFFLEPKKAFLS
FLEAEKEQKRKVVSSSTFVIVASRIGFKNQQIVAGKISSLKNTKFGKPPHTIIIPGKLHF
TESDALKVLAKCYDKPFDNSSKIKKISTQMIEKYVPIIKKSLKEISSHYKNSKEFQVVLE
NAELYIQDAEKFLEEGKDEVAILSIGYADGLVDALRMAKGFEPKM
>A0A075W9Y9|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus DSM 8774|TrEMBL
MLTFVGLGLWDVKDISVKGLEAVREADEVYVEYYTSKLLSSIEEMEEFFGKRVVELERSD
LEENSFRLIERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVCGL
TGLHNYRFGKSATVSWHRSQTPVNVIKANRSIDAHTLLFLDLHPEPMTIGHAVENLIAED
AQMKDLYAVGIARAGSGEEVVKCDRLENLKKIDFGKPLHVMVVLAKTLHFMEFECLREFA
DAPAELERLVA
>A0A7C1RAE9|diphthine synthase|EC 2.1.1.98|Thermococcus sp|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCDKVFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EDVELHFERIVLSEAKDKDVAFLTAGDPMVATTHSDLRIRAKEMGIDSYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTMLFLDIKAEQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLNPTLRAGYVKDMLNEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILEGL
>A0A8J8FAU8|diphthine synthase|EC 2.1.1.98|ANME-1 cluster archaeon GoMg4|TrEMBL
MLTFVGLGLYDEKDITVKGLEAIRAADTVFVEFYTSPLCGKTVEKMEAMYGKRIVRLERS
DVEEHAEERILKRAKHQNVVLLSGGDAMIATTHVDLRLRAMDMGIETGIIHAPSISSAVA
GVCGLQNYKFGKSATISPPYKGGVISEVPYDTIRANKERGLHTLLYLDLSMRIRDALRLL
EAVEEKRSEELLRKSVLVGIARAGSDKPVVKADYLTALKHYDFGELPHVLVVPGELHFLE
KEALIKIAHASS
>A0A7C4E0D5|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
MALTFVGGGLGRFEHLTLEALETIKSVEKIYVDTYTSFWADDFLDKLRETAGHVVVADRK
MLEDNVHKLVSEAVENEIALLTPGDPFIATTHLSIRTIAHRKNVAVKVVHGVSAVSAAVS
SSGLHVYKFGKTATIPKTTDSNMLHEVFKTIETNLSNNLHTLLLLDTSDQGLTVPEAVKQ
LLDYSKQHGKSFINQNTLMVALARLGFPDNVTLAAPAEKLISHNFPPPPHSIIIPSSLHF
TEEEILQTFHKGPLNTAENPLKSRVMNYVSKCRRIIAELSRVHEQTDYLGYVSRYVEDAE
RFIRDGKMADALLAIGYAEGLLDALRLRGEVRFTW
>N0BEI9|diphthine synthase|EC 2.1.1.98|Archaeoglobus sulfaticallidus PM70-1|TrEMBL
MLIFIGTGLWDAEDISLKGLRYARSSDEVYLELYTSKPNIDTDSLSELIGKEVGLLSRSD
LEENSRYLVEKAKERDIVILVPGDPMVATTHTALRVEAKKRGVKTVIIHSSSILSAVCGI
TGLHIYKFGKSATISYPYREKVSKTPVDVIESNRKINAHTLLFLDLHPEPMKIDKAISLL
EQVGNVSEYYGVGIARAGSENMVVKCDKLKNLKEFDFGDPMHILITLSPRIHFMEFEYLR
EFADAPDTLEKLVE
>A0A150J776|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MLYLIGLGLSEKDLSLKAFELLNNIKNIYVDTYTNYFDFDLLWLEKALNKKVIPLSREDI
EKIPTFLEIAKSEDVALLVSGDPLVATTHTDILLRAMKNGVQTKIFHASSIYSAIAETGL
HIYRFGKTASIPYPEENYFPRSFYDVVIENKERNLHTMLLLDVKREKNLFMNPKEAIDIL
IKIDEDRKIKEIIIISRISHDTQRILYGDIYELAKFDNEFYGLPPHTLVVPADLHFAEEE
YLLSLAEIYKNSKNK
>A0A447G2H3|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MTLWFVGLGISGAASAPARAHEVIACADRVYLERFTSPVPDEDVEVVRRLAGERLVLARR
WQVEDGSAILDDAEGGGAALVSYGDPFVATTHAELRSRAISRGIRTEAVHAASAPWAALG
ECGLHSYKAGRTATVMSEGAATPYSVLLSNVSSGCHTVLLLEYDGERGFFLDPSDALRML
LEEEGAQGRGAVSGGTYCIVASRIGSGDQALAAGRISSLSGSDFGDPPHAVLVPGPLHFT
EEEAIAAACKCADPPAGNGSPGTAERMVSRYAPAVRESIREAERLLGPSEVLECAGRYAD
DAESFLAGGRPEVAVLCVGYADGLVDSAMISSGLAPKGYGARDGGGNG
>A0A1H1IF90|diphthine synthase|EC 2.1.1.98|Natronobacterium texcoconense|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSKLIGTTIEDLEAHHDLEIEVRDRA
GVEQEPDDMLEAAEEEDVAFLTAGDTMISTTHVDLRLRAHERGIETHVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDANRADGLHTVVYLDIKVGHERTEED
EYMTADVGAELLAEEYPDLVGVVVARAGSPDPQVEAGTMTDLADREFGDPLHLLVVPGEC
HLLEADALVELAGVDREMLEIA
>A0A3N6PQ39|diphthine synthase|EC 2.1.1.98|Natrarchaeobius chitinivorans|TrEMBL
MLTFIGLGLYDERSITVEGRDALRSADRVYAEFYTSELIGTTVADLESYHDVEIDVRDRA
GVEQRPDDILEAAETEDVAFLTAGDTMISTTHVDLRLRARDRGLETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDDNRADGLHTVVYLDIKVGHERVEED
EYMTADIGADLLADAYPDLVGVAVARAGSPAPLVEAGTMADLAEREFGDPLHLLVIPGEC
HPLEADALVELAGADREALEVA
>A0A830F2P4|diphthine synthase|EC 2.1.1.98|Halocalculus aciditolerans|TrEMBL
MLTFVGLGLYDEHSVTVEGRDAVRNADRAFAEFYTSHLVGADVDDLEAYHDTEIEVRDRV
GVEQEPEPVLDAAESGEVVFLTAGDTMISTTHVDLRLRAHERGIDTRVIHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADGVPGSVVETIEDNKERGLHTLCYLDIKVGRGPRGPD
PDFEEYMTADYAAALLAEHYDPDAVGVVVARAGSPDPLVRADTLAALADGDFGDPLHMLI
LPGDLHHIEQDALTGLAGLPNEHVDD
>A0A4D6HML4|diphthine synthase|EC 2.1.1.98|Natronorubrum bangense|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSKLIGTTVDDLESHHGVDIEVRDRA
GVEQHPDDILAAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTRTIDDNREDGLHTGVYLDIKVDNEAATNR
LEGDETVEEYMTADVGAALLAEEYPDLVGVVVARAGSPDPLVEADTMAALAEREFGDPLH
LLVVPGDCHLLEADALVELAGVDRDDLDIV
>A0A2B7GVR6|diphthine synthase|EC 2.1.1.98|Natrinema sp. CBA1119|TrEMBL
MLTFIGLGLYDERSITVEGRDALRAADRVYAEFYTSQLIGTTIDDLESYHDLEIEVRDRA
GVEQHPDDMLTAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVLHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIDDNRADGLHTVVYLDIKAEREEYMTA
DIGADLLAEEYPDLAGVVVARAGSPDPLVEAGTMTELADQEFGDPLHLLVIPGECHLLEA
DALVELAGADRDVLEIA
>A0A6B0SSW8|diphthine synthase|EC 2.1.1.98|Halobacterium bonnevillei|TrEMBL
MLTFVGLGLYDERSVTVAGADAIAAADRAFAEFYTSRLVGADVADLEAYHGIDVEVRDRA
GVEQDPEPMLAAAETEDVVFLTAGDTMISTTHVDLRLRAEDRGVETRVIHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADGVPSSVVDAIEANRERDLHTLCYLDIKVDHPRADGD
EYMTASHAAGLLADHWDPDAIGVVVARAGAPDATVRANRLAALADEDFGDPLHLLVVPGD
LHHVEADALAGLADAPANVLDEYRD
>A0A3G3IHY5|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilus alvus|TrEMBL
MTSELVFVGLGLSGVDGMTVKALNALKECDKIYAEFYTSNLIGTEVSDLAEFIGKEIHVV
YRSEVEEGHDIIEDAKTMRVAFVTAGDTMLATTHVDLRIQAVMEGIPVRVFNGISIFSAC
PTCLGLQPYKFGRTVTLPFLERNYQPKSPYDHIMENKKRGLHTMILLDIRAEELRYMTAK
DAIEWLLAGEEKWGEGLITDKTLLCVVSHAGAEDEKVVAGYPRDLLQMDLGAPLQTLVLP
GELHFMEAEALVDFAGAPEEIIQDDE
>A0A832Z7E0|diphthine synthase|EC 2.1.1.98|Pyrodictium sp|TrEMBL
MLYLVGFGPSARFLSIAALQALACADKVYVDTYTSFAEGLDLKLVKLLAPRAEVVKASRK
HLEDLSHKIVDEAKHANIVVLVAGDPLTATTHNALRLEALKQGVKVEVIPAVSGLQLVIA
VTGLSWYRFGRPITLVFPEEHYKPYSTVEVVVDNLERGLHTLVLLDFRVDQGKIMDVKTG
AKLLFELAEEMGESFSKRLREAVMVGVARAGFSDQKCVAGRLEDILASEFPPPPHTLIVA
HPRLHPVEEDLLKHLCGFKKSNY
>A0A7J3A752|diphthine synthase|EC 2.1.1.98|Nitrososphaerales archaeon|TrEMBL
MLYFVGLGLSGVESITLEALKALKGCKTVYLERYTNPSAPSAKELAEFLGRDVVEVSREF
VEDGRRILREAKEADVAVACSGDPMVATTHQELRVRATKEGVDTKIIHGTSIVGCIAGEL
GLHQYKFGKTVTVTASPPTHSTVLDTVYWNLLRGLHTLLLVEWQPNRTLTPNEALKMLMD
ADEEARLGIFNPNLFTIVAARLCQRNQLIKAGLLKDLLHLDYGEPPYSIVIPADLHFTEA
EALEALFKSECSNVNNTQYAKSKANVLVPRYVEKTRATLKKVREMLATKELKLNTSDLLE
NVDCYSSDALRFLNEGKTELAILSIGYAEGLLDSLRFIGLVEVPW
>A0A1Q7SS18|diphthine synthase|EC 2.1.1.98|archaeon 13_1_20CM_52_20|TrEMBL
MSVTFVGLGLNDEKGLTVEGLEEARKADAVFAEFYTNIMPGLDVEKLELLLGKKIVVLDR
AQLEDENGRQILEATGRGKVAFLVPGDPMIATTHVSIMLELARKGIQSRIVHGPSITSAV
CGATGLQSYKFGKTVTMPQESGVPGSLVEGMMDNRKRGLHSLVLLDVRSDRSKQLTVGEA
AAKLVAADPLFESWLGVGVARVGSRDQFVLAGRLGRLQREDFGKIPHSLVIPGRLHFVEV
EFLKVFCGANDEDLESLK
>A0A7J2TJX2|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus|TrEMBL
MLYLVGLGLWDPKDITLRGFEIVRNANAVYAEFYTSKLGVGVEELERFFGRKIEVLKRED
LEEKSLKILEKAKKEDIAILVAGDPMIATTHIALVVEAKKMGIGTKVVSNAGIINAVCSL
TGLQSYRFGKSATVSWHRSRAFIDVVKANLSIDAHTLLFLDLNPPMKIADAVERILELEK
SLENHFAVGIARAGSENPAVKCDRLKKLREFDFGDPLHTLVILSRKIHFMEFEALRLLAS
APEDLKEWVS
>V4J8V2|diphthine synthase|EC 2.1.1.98|uncultured Acidilobus sp. CIS|TrEMBL
MLFIVGTGLGPQHVTDRAKSLIKKADVVIVEAYTSPNSGWLEDMAKALNKATVKATRDLL
EENVNTLIDMARSRDVVVLVAGDPLIATTHSSVVVEALTRGVKAKVIPGVSGPCAAMSLS
GLQFYRFGRKVTVPGPWRGTDATPVAYWLLGNLCLDLHSLILLDVDQEGGQLPPADGARE
LLKAFNELLSDQRADLGDLLVLAVSATDDDVNVTYSRLSEPEALRSVIPSTMIVPASLHP
VEQEFLKSVHGVPLSLIDLHLKLLRRIDPCSLYFSGRRKVMASP
>A0A133U438|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA259B11|TrEMBL
MLLFVGLGMNSKGISIQGLEEARSADVVYAEFYTSIIPGFEIEKMEESISKPIRVLDREA
VEVSPDEILKKSETKKVVFLVPGDPMVATTHVDLRLRAGKRGIETRIIHGASIETAGPGL
AGLQSYKFGKTATLPLPEKRSITPYDVLEDNKKQGLHTLFLLDIEKEEERYLTADRAIEY
LLDLEEELERKVYTGDTLSVVVARAGSEDPLVKADRCGNLIGRGFGRPPHILIVPGKLHF
LEAEALEYFADAPKEVVEEYVKE
>A0A7C4YDT3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLHDEFGISLKGLEEAKTADAVFLEAYTSFMPSFSLENFERLVGKRVMVVS
RKQLEDENGRVVLEAALKGKAVLLVPGDPLVATTHVAVRLEAQKRGIKTRIVHGASIVSA
VMGLCGLHNYKFGKSVTIPFPENFSETPYNVLAQNMRLGLHTLCLLDIDVEKNRFLTVRE
ALEMLLKVEAEKQFGVLGEETLAVGVARAGSPNPTVKAGFVNELLDYDFGSPPYSLVFPG
KLHFMEAEALVVFAQAPPSVWRLVE
>A0A7C3U737|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTLKFIGLGLYDEYGISLKGVEEARKSDYIYIELYTSLMPGLSVKNLEAMVGKPVKALTR
TDIEERPEESILKKAVDKEVALLVPGDPMNATTHIDLRLRAESMGIKTILIHGASITSAI
PGVTGLQSYKFGRTVTIPLPRNHPPLSPYDHILQNYSRGLHTLIL
>A0A497L073|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGRGLKLISIGLADEYDLSLRAIEEARSCDKLYVELYTTRLSTSRERLEEVLQRPLTELS
RMDLEGERPRILEEASRSLIGLLIGGDCLAATTHISLLLEAKRQGIPTWVIHGSSIFTAI
AETGLSLYKFGRIVTLPLPERGPPDTVLEALEGNLSLDLHTLILLDLDVERDRWLSVSEG
VRFLLEADRPEVFNEETPAIGVARLGWSNPLIKGGRAVDLLDVDFGDPPQALIIPGRLHF
MEEEGLRLLADCPGEALKGWRPRGEPEHLVERYMKSCRGVMEKLRDKPLSEEARRILDYA
ARYLSDAEYYAGEGRWPTALAAISYCEGLLDALRLLGLAEFEW
>A0A537EFW6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVAFIGLGLNDERGLTLEGLEEARQASSVFAEFYTNIMPDLDRKKLELLIGKKVVVLNR
IQLEDEEAKPIVEAFGRGKVAFLVPGDPMIATTHISIRLELARRGIPSRIIHGPSVTSAV
CGATGLQSYKFGKSVTLPQEPGVPGSLLDTVRDNKNRGLHTLILLDIRPEMTQQLTIAEA
AAKLVAADPTYERWMGVGVARIGSTDQFVLSAKLGKLQNQDFGRIPHCLVIPGRLHFMEI
EALKAFCGAEDADLEALK
>A0A497KL33|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
DNIETKVIHGSSIFTSITDTGLSIYKFGKTVTIPLPEKGPVDTAIRTIKENYEHGLHTLI
LLDLNMAEEKYLTIPHAIKRLIDTGEFNPETLLVGAARLGSRFPAIKADTAKELLHHDFG
EPPHTIIAPGKLHFMEEEALEALADCPRKVIQNHKPVGETDRLITKYSVGCRKVLDELKA
RNLPVEITSEQLEELLKHTENYLYDSEYYRVDKKATALTCVAYAEGILDALKLLGIVDFE
W
>A0A7L4PE25|diphthine synthase|EC 2.1.1.98|Methanocellales archaeon|TrEMBL
MLTFIGLGLYDERDITLKGLEAIKDADIVFAEFYTSALTGTNLDTMEHLYEKKIIIVDRE
DVERANQILSCAKDQKVVFLSSGDSMIATTHVDLRLRAIDQGIRTRIIHGPSIYSAVCGL
TGLQNYRFGKSATIAFPYKKQISEAPYDTIKANKEHNLHTLLFMDIKENYMKINQAIELL
FRVESIREEEVINGIAVGISRAGSEEPIVKADYVDRLHKYDFGKDLHSMVFPGRLHFLEA
ESLIKLASAPPEIIEEVL
>A0A1J1ABN2|diphthine synthase|EC 2.1.1.98|Halodesulfurarchaeum formicicum|TrEMBL
MLTFVGLGLYDERSVTIEGRDAIRDAEAVFAEFYTSRLVAATVEDLEAYHDVTIQVRDRA
GVEQDPEPILEAAETGPAVFLTAGDPTVSTTHVDLRLRAHDRDIETRIVHAPTAQTAASG
LTGLQNYRFGKSTTIPFPWAHGADGVPDSVIETIEANRERGLHTLAYLDIKAESAELMDG
ATAAELLTEHWNGDVLGVVVGRAGSPEPTVKAASLEALSELSFGPPPHMLLIPGDLHPIE
VDALAAFGDAPKDQLE
>A0A7C0UKI0|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MKHMLVFIGLGLYDEKDLTLRGVEEARSCSQLFAEFYTSRLSGTTLEKLEGVLEKKITVL
SRSEVESGDVILKAAETGKTGFLVPGDPLISTTHIALRIDAKQRGIETRVVHNTSINSAA
PGLSGLFNYKFGASSSIPFPSEGYRPDSFYHVASENKKRGLHTLLFLDIKDRLMTV
>A0A6B0DEI8|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLRLIGIGLNPKKHMTLEALEKINDSDEIYLELYTSRIVDMTLDELENLINRKITLLDRK
TIESEFLVERSRKMKVSLLVPGDPIIATTHIGLVISSIQNNVEYEIINGISVQCVVPSIL
GLQNYKFGRSVSIPFPEYDYYPESVYNFVLENRKLGLHTLVFLDLRESLEMSALMGIDIL
LKMESMYRKDAIDKNTIIAVISKAGSEKQRAIADKIERIKERDLGPTPHIMVIIGSLHYM
ELEALKKLASFPENENINLL
>A0A327HCC3|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MSLGGSSQVRGLRMKSDDETGFALIGMGPGKVESMTLEAVEVAKNADVRLYEAYTALWPN
DELERLETMIGPIERIMRPAVERPETLFEQAKDKLVAILVVGDPMQATTHIDFQLRAEKE
GIPVRVIHGISVTTLVPGSTGLSDYKFGRSTTLTYPYGDWIVTSPLEVMLRNKEQGLHTL
VLFDLDPTGAGTGDQRPMQPQDAFVSIEKMVEKLGHSEMEESIKQQASDLLDSEIVLCCD
LGTNDAFLKTTTVGSLRNLSGGRLNCMVFLANMSEMEQEAVQRWS
>A0A7J3B8T6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MIGFISSGFNPPDSLTSEEISFMEGCSKIIVDTYTSPNFLKEFRGRNLFLAGRNDLENFQ
WIFDERGDISIVIPGDSFSATTHFTIYKEALKRGLDVRVFHNSSIFPTAATRLGLHVYKI
GPPVSLPRFREGFRPTSPYLKINDNMSRGLHTVVLLDTEPPMTLKEAISEMELMEREVHL
GIIKGERMIGVVASLGTKDEKLMYGEIRELRDIESPIPVTLVIPGELHFQESEALELFRV
>A0A7C5FJT6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MTLYIIGLGLEGAASIQQRGLVAIKQCSSVFIETYTSGSRDNLIDDIEKLTGKNILQVTR
EKVEQSRIILNSARTTDTAFLVQGDALTATTHNQLRFDALGEGITVEVMENASIITAVPG
YLGLEVYKMGQVVSLPYVSEKFFPRSPYDKIISNMERGLHTLTLLDITETGYMSVNEACD
ILRKMNDQFGRKLDLETLKVAVVHAYGTRFLSARYGVLGKLCSLKYTENPSTLVIPGKLD
YNEQEFISHFNV
>M0GKG8|diphthine synthase|EC 2.1.1.98|Haloferax lucentense (strain DSM 14919 / JCM 9276 / NCIMB 13854 / Aa 2.2)|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7K3YYI3|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLFDKTDISLKGLRCIEQADAVFLESYTSRLMGTTVEDLAALYKKPVRPLYRE
DVEQNPEEILVLAEKKAVVFLCAGDPMVSTTHADLRLRAAGRGIRTSIIHGASIVSAVSG
LSGLQNYRFGKSCSLPFPQKNWFPMSAVDVISTNLEQRLHTLVYLDIQDNRYMTIPEAVL
LLEEMGEKKGVHIPLYVGVARAGSDSPVVHAGPAESIRNIEFGPPLHILIVPAELHDMER
EYLEVFAGL
>A0A2T9WY06|diphthine synthase|EC 2.1.1.98|Sulfolobales archaeon SCGC AB-777_J03|TrEMBL
MGHLLLVGLGLSWKLTTPMAIEALKRSDVVYFDSYTSYSCDIDENKLLNEGINVIKATRK
DLENESHKIIKLLEEGKRVAIASVGDPIIATTHIALAIEAAKRGHKIRIVPGVSVLCYFL
SKTGLSSYKLGRSVTVTFPDNVMSETPYRVLKANDEQGLHTVMFLDLKDGRMMRAEEAIR
ILLELEKRFGEGVIHPERLVIVGERLGCDDERVIVSSVSEVQQMINNEPPHILLFPARKL
HFVEEEGLQWLMRSAIE
>A0A510BEX8|diphthine synthase|EC 2.1.1.98|Methanofervidicoccus sp. A16|TrEMBL
MLILAGLGLYDEKDMTLKTLEYAKKADKIYAEFYTAVLTGTTLDKIEEVLGKKIILLSRE
DVEYRGNKLIEESRDKVVMFLTAGDPMVATTHIDLVIEAKKRGIDVRVINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYNIIRDNLKMGLHTLCLLDIQTDKNRFMSANEGL
KILLELEDRKRENILSRDTKVVVLARAGSLKPKIVYGKIGDLIDYDFGPPLHSIIIPGKL
HFMEEEALKYLCENIP
>A0A7C1SCR0|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLHIIGLGLAVDGISKKGIDILKSCKKIYLENYTVEFPYNTRGLAELLGKKKIHPANRKF
VESLRIVDEAKKLDIALLVYGSPLTATTHISILDEAKKSGVITKVIHSASIFDAVGETGL
QLYKFGKTASLPNLEADSYINIIKENLQIGAHTLILVDIGMRFEVVIKKLKEDSEKKDLT
LKKIIVCQRLGTNQSEIFYKGFEKLEKLEGEDEIRAPFCMVVPGKMHFLEKEFLDNFK
>A0A2V2NC15|diphthine synthase|EC 2.1.1.98|Methanospirillum lacunae|TrEMBL
MLTFVGLGLYDLDDVSLKGMHAIEEADHVYLESYTSRLMGTDLAAMEKRYGKPVHILKRE
DVEQHPESVLAAAKTGNVVFLTGGDPMVSTTHSDIRIRAAEQGISTRIVHGASIASAVCG
LCGLQNYRFGKSCSVPYPAKNWFPKTPFETIKANQKADLHTIVFLDIQENRYMSISEAVE
ILEKLSAEDGTRIHLYVGIARAGSPEPVVIAGSAEKMVKADFGSPLHILVIPAQLHPVEE
EYLRTFADL
>A0A5E4KXD0|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVRKADIIYAEFYTSNLMGTDLEKIEKFYGRKVIVLTRE
NVENNPVWLREAIGKNVVFLTGGDAMVATTHIDLRLRAKDLGIATAIIHAPSISSSVCGL
TGLQNYRFGKSTTIPFPYSRGDKIIISEAPYDTIKMNKKNDLHSLVFLDINMEKGFMDIR
KAASLLLEMEGQRGEGVLVNTLAVGVSRAGSYSPTVHADYLERLKDYDFGAPLHILIIPA
SLHFIEAEALVKFCGAPPEIIK
>A0A075HLB1|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote KM3_74_G02|TrEMBL
MTHHTRKSDKHYSLDDDGGWTMTNFESGLWLIGLGPGDLSAMTTASIEAAKSCNYRFLEG
YTALLPSGEGAKLVEIVGEYELLMRPEVENPDRLLELASENAVALMIVGDPLQATTHVDL
QLRAKAAGINCHVIHGISITTIVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNL
QRDLHSLVLLDLDPTGMGIDEQKPMSPAMAVDILRRSADKIGENIEQWKIVLCSDMGRPE
QRIFYGTLDDVESINNGSIHCIVIPGRLDELEVEALARWN
>A0A8J7S0J3|diphthine synthase|EC 2.1.1.98|Methanococcus voltae|TrEMBL
MLIMAGLGLYDEKDLTLKTLEHAKKADKIYAEFYTAILTGTTLETIEETLGKKINVLDRE
KVEYETEKLINESKDKDIMFLTAGDPMVATTHVDIAVEAKKKGIEVVIINAPSIYSAIGI
TGLQIYKFGKTTSVVFPEPNYFPETPYNVIKDNLSLGYHTLCLLDIHAHENKFMTANEGL
QVLLDIEERRKENLLSEDTKVLVVARAGSLKPKLVYGKIKDLIKQDFGAPLHSIIVLGNL
HFMEEEALEILAENI
>A0A7K4DAL2|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosa archaeon|TrEMBL
MLYLIGLGLSEKDLSLKAFELLSKINNIFVDTYTNYFDFDLLWLEKELNKKVIQLSREDI
EKRPIFLDIAIDQDVAILVSGDPLVATTHTDILLRAKKKGIKTKIFHASSIYSAIAETGL
HIYRFGKTASIPFPEENFFPKSFYDVILENKGRNLHTMLLLDVKKEKNLFMNPKDAMEIL
RSIDKDCNIQDIIIISRISHDSQRIIYGDIEELLKFNAEFYGLPPHTLVVPATLHFAEEE
YIISLAEIYKNTKN
>D5VSE4|diphthine synthase|EC 2.1.1.98|Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)|TrEMBL
MLILAGLGLYDEKDMPLKVLEFAKKVDKIYAEFYTAALTGTTVEKIEKVLGREIEVLDRK
KVEYGSEKLVEEAKEKDIMFLTAGDPMVATTHVDLAIEAKKKGVELIIINAPSIYSAVGI
TGLQLYKFGRTASIVFPEKNYFPETPYNVIKENLERGCHTLCLLDIHAEENRFMTANEAL
KILLELEKRKKEGVISEDMKVIVLARAGSLKPKLVYGKIKDLLNYDFGKPLHSIIIPGKL
HFMEEEALKYLCENID
>U6EEF9|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. MB1|TrEMBL
MLYLVGLGLYNEKDISINGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINVLRRE
EVEEHDLPLKQAETKDVAFLTAGDPLMATTHTEILVEARKKGIPTQVIHASSILSAAPGL
AGLQAYKFGKVTTIPRPEDNYFPHSPYQAIAENKKMGLHTLVLLDIQAHNDYYMTANEGL
QYLLRVENERNEGIITMDTLTVVIARAGSAQPLVCANSVGVLVEQDFGGPLHCMIIPGDL
HFMEEEALNILGGAPENILQG
>A0A843K5U4|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLTFIGLGLYDEKDISVKGREAVAAADRVYAEFYTSRLMGATLSRLEQFHQKKIHLLIRS
QVEVETSWLEQAKDEDVAFLVGGDAMVSTTHLDLRLRAMRLGIKTRLIHSASIVTAVSGL
SGLQNYRFGRSTTIPFPYLARGKRIVPETPYRVLQENLARNLHTMLFLDIQMEPEERYMT
AGQGAALLLEMEGKAEEKLPPKVLGIGIARAGSDDSVIRADLLTRLKNCDLGGPLHILVV
PAKLHFMEAEALRVLAAAPEDAFMGAD
>A0A257MIF0|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. NSM2|TrEMBL
MLTFIGLGLFDERDISVKGREAVAAADMVYAEFYTSRLMGTSLARLEKFHGKKIHLLTRS
QVEVEPFWLEQAKEMDVAFLVGGDAMVSTTHLDLRLRAMLMGIKTRLIHSSSIVTAVSGL
SGLQNYRFGRSTTIPFPYLARGKRIVPETPYRVLQENLARNLHTMLFLDIQRDPVERYMT
AGQGAALLLEMESEAEDKLPPGTLGIGIARAGSDDAVIRADRLSRLKDCDLGGPLHILVV
PARLHFMEAEALRVLAAAPEDALMGAD
>A0A0E3RE43|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei SarPi|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A832C5W6|diphthine synthase|EC 2.1.1.98|Archaeoglobus sp|TrEMBL
MLTLVGLGLQDYRDITFRGYEAVKNAEEVYLDTYTSRISSSIEDLQRFFGKRIIEAKRND
LEEGSRKIIEKAKEKDVVILVPGDPTIATTHIALVLEARKANVETKIINNASIINAVCSL
TGLQNYRFGKSATISWYRSKAFIETIYANLSIDAHTLLFLDLNPPMTIKDAVNRILELDS
SFKDYFAVGIARAGSEDAVVKCDRLRELAHFSFGDPLHSLVILSKKLHVIEYECLTYFAS
APEELRDLVL
>D3S8I5|diphthine synthase|EC 2.1.1.98|Methanocaldococcus sp. (strain FS406-22)|TrEMBL
MMLILAGLGLYDENDMTLKTLKFAKKVDKIYAEFYTAVLTGTTIEKIEEVLGKKIHVLSR
KDVEYNGYKLIEEAKNKDIMFLTAGDPMVATTHVDLVIEAKKKGVEVVIINAPSIYSAVG
ITGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIDENEKRFMTAN
EGLKILLELENRKKENVINEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIP
GKLHFMEEDALKYLCENI
>A0A7J4MCC9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MPLIGTTGQDGISMTVELPPTGLLLVGLGPGGLRSMTVAALEAAEKADHRWYEAYTALWP
EPDLIELEARTGPIERVMRPDVEDPGRLFELARTSLVAMLVVGDPLQATTHVDLQLRARE
AGVPCHVLHGLSITGTVTGAAGLSNYRFGRQTTLTYPHGSWIATSPLETIAMNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHLMTERLAERSEEAVSELKSRAMQNQDIGSWT
VVLCADVGTADEFFVTTTVDGLPAEPGGRLNCLLVPAEVDGVEADAIGRWRRP
>A0A2Z2NAY0|diphthine synthase|EC 2.1.1.98|Thermococcus radiotolerans|TrEMBL
MAIYFIGLGLYDERDITLKGLETARKCDLVFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EEVELHFERIVLSEAREKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEDMKKENVFTPNTLVVVLARAGSLNPTLRAGYVRDMIQEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A5A7S2F2|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLSFIGLGLWDERDITIKALEEARKCDKVYAEFYTSKMGVETEKIERMIGKKITVLEREE
VEDGEKLLEEAEKLHVCLLTAGDPMAATTHVDLRIRAIERGIKTKVYHGISIVSASASLL
GLQIYKFGRVASIVKPSENYFPLSPYDVIKENTMAGMHSLLLLDISDECMEANEAMELLL
EMEKRKKGGIITTDTLVAVVARVSSDDALARAGYIKDLIKEDFGRTPHSLIIPGKLHFME
AKALVTIAKAPKEIMNLVI
>A0A662K8W9|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGELIFIGLGLYDEKDISLKGLEVAKRCDYLFAEFYTSKLTGTDISKVEKILGKKIKVLG
RKEVEDGEQILKEAEKGRVGFLTAGDPMAATTHVELRIRAEERGIATRIVHGSSVFTAVP
ALLGLQHYKFGRTTSLVYPEDNFFPTSPYYVIKENKERGLHTLVLLDIDAEKERFMTIRE
GIDILLEMENRLKEGVISDDTIVCGVARAGSKKPIIKAGSILEVRNFDFGPPLHTLVIVG
KLHFMERKALETFAGLTRENRSV
>A0A849PWZ6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSLAGLEAARTSDQVFAEFYTSKLSGTSIERLEARIGKAIHVLGREGVEEDPEPMLEAAA
GGTAVLLVVGDPMAATTHIDLRLRAERIGIHTRVFHNASILTAALTELGLSVYKSGRVTT
LQWPHGDYFPTSPYEHIMANVEAGLHSLVLLDIHSDEDRYMTANEGCRLLLRYEDMLGNG
VTGPDSLACVVAGVGSPDCKRRAGRLGELAEEDFGPALHSIIVPGKLHFMEARALVVLAG
ADPHLVGEGV
>A0A7C1T1X2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MSKGEILFIGLGLYDERDISIKGLEAAKTCDKLFAEFYTSKLSGADTSKLEKIIGKPIIV
LERNDVEKGEEILEIAGKSRIGFLTAGDPMAATTHVDLRLRAQERGIETRVIHGSSVFTA
VPGLLGLQHYKFGRSTTLVYPEDKYFPLSPYTVIKENKERGLHTLVLLDINREKGRYMTI
GEGIEILLKMEKETGYGMIDDNSLLCGVARAGSDNPTVRAGPARILKRIDFGPPLHTLVV
PGNLHFVEEKALEVFAGLKR
>A0A4U7F139|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SD626R|TrEMBL
AERGIDTRVIHGVTAQSAASSLTGLQNYRFGKATTLPFPYAHGGDDVPQSVIETIEANRE
RGLHTVVYLDIKVGTGPTGPDPDHEEYMTADVAAELLAEGWEDVLAVVVARAGSPDAVVT
ADRLSALADRDFGDPLHLLVIPGDLHHVEADALAGLAGAPDDLVER
>A0A498FB53|diphthine synthase|EC 2.1.1.98|Halobellus sp. Atlit-31R|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAVAEFYTSHLVGATVDDLAAYHDIDIEVRDRA
GVEQHPDDVLDAAEDEHVAFLTAGDTMISTTHVDLRLRAIERGIDTRVIHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVVDSIEANRERGLHTVVYLDIKADRDEYMTA
DVAAELLAAGWQDTLGVVVARAGSPEPTVVADRLSALAAQDFGDPLHLLVIPGDLHHVEA
DALATLGGAPDDVLEESRI
>A0A7J4NN55|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MNSDNGLWLIGVGPGNIGLMSLDAIEAVKRCDYRFLEGYTALLPTDQEEELENLVGEYKK
IMRPDVENPEDLLKLAKEGAVALMVVGDPLQATTHIDLQLRAAEANIGCHVIHGISITTI
VTGVVGLQSYRFGRQVTLAYPYGDYLATSPFELILENLERNLHTLVLLDLDPSGMGEGEQ
QPMSPRGAVEILQLSAKKLKHDIEDWNIVLCSDMGTTSQRINYGSLDHISAIESGDIHCM
VIPGRLDDLEQEALARWKA
>A0A7C0X302|diphthine synthase|EC 2.1.1.98|Candidatus Syntrophoarchaeum butanivorans|TrEMBL
MLTFVGLGLYDERDITLRGLEAIRSAEFVYLEEYTSRLGGCNREKLEGVFGRKVLPATRT
DIENDPEEILRRAASSDVVLLTGGDPMSATTHIDLRLRAHDRGIKTRIIHAPSIFTAVAG
ITGLSSYKFGKSATISYPWGERGVISEVPYDTIKINRAHGLHTLLLLDISNGRCMRIHEA
LKILSMLEEKRDEGVVDNLLFVGVARAGSEDMTVKAGDLETLMHFDFGPPLHVLVAVGEL
HFIEHEALVKFAGLKGDL
>A0A522YWF5|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotenuis sp|TrEMBL
MLWFVGLGISGPDSLSDKTKKIISDADAVYFEQFTSPMKNDESQKIRELAKGQFKFAPRW
LVEDGKEILDSAKTKNVVMVTYGDPYIATTHIELRTRAIQEKIQTNTVHASSAITSLVGE
CGLHYYKVGRTVTVMSGIPSSTAYYTIYENLRVGNHTVILLEYNQNEDFFLNPKNAIESL
LESEKEQVRKVISDSTYGIVASRIGQQDQKIIAGSFASLKKTDFGNPPHTIIIPGTLHFT
ESDALKVLAKCIDEPNDNSSKIERIASQMMKKYVPMVRRALEQITPHYKDAKEFQSVLEN
AELYIRDAEIFFEQGKDELAILSIGYADGLVDALRIAKGIEPETNS
>A0A842X164|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYLIGMGLHDERDLSLKAVEALRGCERVYLESYTSCFNGDINRLQEMLGKEVVLLDRKD
LEENPEENVLAGGEVGLIVMGDPMVATTHSDLVLRAREKGAEVKVIHSSSVYSAIAETGL
QIYKFGRTTTIAYPEGDYFPKSPYEALKENHMRGLHTLLLLDVKADEGRYMTVNEGIKYL
LMMEESCLQNQFKKDSKCVGVARLGGDTAIRYGTAEEVIKEEFGGPPHILIVPGKMHYME
EEMLKAYEV
>A0A7J3IIN9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVLGELVFVGLGLHDERGISLKGLEEARTASAIFLEAYTSFMPGFSLESFERLVGRRVVV
VSRRQLEDENGRVVLEAASDGKAVLLVPGDPLVATTHVALRLEAEKRGIKTRVVHGTSIV
SAVMGLCGLHNYKFGRSVTIPFPENFSETPYMVLAQNRGLGLHTLCLLDLDVERNRFLTV
REALETLLKIEAEKRLGVVDMETLVVGVARAGSPNPTVKAGTVGELLDYDFGGPPYSLVF
PGKLHFMEAEALIAFAKAPATVRRLVE
>A0A2L1C8Z0|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIESTLQKPITVLDRE
KVEYETNKLIDEAKDNDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISGETKVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>A0A7C2LE93|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MGITFVGLGLGPKRYITEAALESIKAADVVFLDVYTGILPDETIDFLRTISKHLLIADRY
LLEDGIDAVLAEATRKSVVIAVQGDPLIATTHISIVLEARKRGIACKIVSGISSYSVAAS
LSGLQAYKFGRAVTLPMEEDIEYAKSVYESILENMSRGLHTLLFLDTKNGGLTIPVALSR
LRELERLLRKGVASDDRLVVALARLGYDDELIKAGRIADLATMDFPKPPHMLIFPGKLHF
LERETLVRLLGAPRECVEAYEPINYEVGRVKRYIDACERVLSKLGTSAEETKVNEVLNVA
KSYLDDSKFFLKSGDLFDSLSAISYCEGLLDALRMMGYVEFDWKS
>E4NQS1|diphthine synthase|EC 2.1.1.98|Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3)|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEDLESYHDIDVAVRDRA
GVEQHPEDILDAAEDEHVVFLTAGDTMISTTHVDLRLRAVERGIDTRVIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPKSVIDSIEANRERGLHTLVYLDIKADRDEYMSG
DYAAEMLADGWEDVLGIVVARAGSEDPLVAADRLSELAERDFGDPLHMLVIPGDVHHVEA
DALRTLGGAPDEVLSENEV
>A0A7L4Q9H4|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon|TrEMBL
MGELIFVGLGLGGPKDMSRRAFEHIREADEVFAEFYTSSLIDCTVQDLEEELGRTIIVLE
RKEVEEEDRIVEAARKEKVAFITAGDTMAATTHVEIRLRAEEFGIPTTLIHGVSIFTAAA
SALGLQPYKFGRTVTLPLPEPGYFPTSPYDNIVENKERGLHTLLLLDIRRDENRYMSSME
AVEWLMEAEGKVGKGLIHEKTLICAAARVGSSSEKVAAGYPNRMLKLDMGPPLHCLVIPG
KLHFMEAKFLVSFASAPGDIVKD
>A0A843JPY6|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MTSELIFVGLGLSGTDGMTVKALNALKECDKIYAEFYTSFLIGTKVEDLEEVIGKKIKVL
YRAQVEECDDIIKDAKEMRVGFITAGDTMSATTHVDLRIQAAELGIPVRLINGITIFSAC
PTVFGLQNYKFGRAVTLPFIEQGYHPKSPYDHIMQNKKLGLHTMILLDIHADEMRYMTAH
EAIEWLMLGEEKWQEGLIDDRTILCVASQVGSPNEKIFAGYPQDLLKMDLGEPLFTLVLP
GNLHFMEQYALVKFAGAPEEIIEDE
>A0A7J4UGV4|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLYLIGLGLNIEGISRFGFEILQRCKRVYLENYTVDFPYTIGELQEVIFQGKTKKLLLAN
REKVENLELIDEAKKMDVALLIYGSPLSATTHISLIEEAKKTKVKYKVIHAGSIFDAVAE
TGLQQYKFGKVTSMPAWKKNFEPTSFMKIVEENISINAHSLILIDIGLDFQNALEQLEIS
AKEYNIKLNKLIVCQTLGTKSQKIHYKEIEELKEYNGIKKPYCIIIPSKLHFIEEEMLKE
I
>A0A3M9LKF9|diphthine synthase|EC 2.1.1.98|Methanohalophilus sp. RSK|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNADKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEMDIAFLTGGDTMVSTTHVDIRLRAMELGIETRLIHGASIVSAICGL
TGLQNYRFGKAATIPHPYTSSRGNTIISETPYDTILRNRQLGLHTAVFLDIDMNKGYMTV
NQGIELLLKIDEKRGQNLIKGSIAVGIANAGSEKPIVKADFAEYLESYDFGSPLHIVVIP
ADLHFVEAEALVKLADAPESILEEGEEN
>A0A1I0P8N3|diphthine synthase|EC 2.1.1.98|Halopiger salifodinae|TrEMBL
MLTFIGLGLYDERSITVEGQAALRAADRVYAEFYTSKLIGTTIDDLESHHDVEIEVRDRA
GVEQEPDDMLAAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDENRADGLHTVVYLDIKADREEYMTA
DVGADLLAEAYPDLVGVVVARAGSPDPHVEAGTMTELAEREFGDPLHLLVVPGECHLLEA
DALVELADADRDTLDIV
>A0A6A7LFP9|diphthine synthase|EC 2.1.1.98|Nitrososphaeraceae archaeon|TrEMBL
MLWLIGLGIEGLGGMSMKGRAILETCNLIYIERFTGYLSESELRELRLHCKYDDNVVNVV
GRLFVEDGRDILEQASNNEVAIIVYGDPLIATTYIELFLRATKRSIKVEVIHSASGITSL
IGESGLQIYKFGRTSTIMSEPQSALSVYNTLFDNLLLGNHTLILTEYNETKDNISPFFLD
PNDALKMLLDVEKDQRSRAFTEETYVIVASRIGTADKKIISGQTRSLLEINYGTGPHSLI
VPGRLHFVEKEAISNITSILNEPTENSSRVTRISTRMVEKYVPSVKKTINELRKRLPTDS
TQYKGINAVLDNAEYYVQDAEKFLNQGKNELAVLSVGYAEGLIDAISFQRGLDPW
>A0A5N5U8C9|diphthine synthase|EC 2.1.1.98|Halosegnis rubeus|TrEMBL
MLTFVGLGLWDEDSITVDGQRALRAADEVFAEFYTSRLVGTDPESLATHHGVDIDVRDRA
GTEQEPEPILDAAESGDAVFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGTTASAAAAS
LTGLQNYRFGKATTLPFPYAHGGDGVPNSVCDTLDANRERGLHTLVYLDIKQERGEYMTG
DVAADLLADGYEDVLGVVVCRAGSPEPRVEAGLLSDLATREFGDPLHLLIVPGELHYIES
DALRELAGAPEELSEPV
>A0A6A8RM85|diphthine synthase|EC 2.1.1.98|Methanobacterium sp|TrEMBL
MIYFIGLGLYHETDISLKGLIALKKVDHIYAEFYTAKLFGGNIKNLEELVGQEIQVLTRE
EVEEGNIPLKKAEVDDVAFLIAGDPLIATTHSEMLIQARKMGIKTNVIHSSSILSAAPGI
AGLQAYKFGKVTTVPFTEKNYFPHSPYMAIKSNMDSNLHTLVLLDIRAHEDRYMTANQAL
EYLLQVESIKNENVTTEDSIAVVVARAGSDEPVVKADKIKNLIGQDFGGPLHCLMIPADL
HFMEAEALVELADAPKELFEDME
>A0A7C4M468|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MKKPYFYIIGLGPTPKHVSYQAIEILSEKCDSVFYEEYTSIPSEGDLSYIEEMIKKKATK
LNRRDLEDLSGEIIIRSLREGRNTCLVTWGDPLIATTHISIITRVVHEEFKYRYIPGINS
VSVALAASGLMIYRIGKIATITYPREGVISEYPYLVLRENLSRNLHTIFLLDIDSEKNIY
MNAREAIKILLDLEKRFGEGIFSSKSLVLVVNIANNIMICGGEANYVLENPPNNYPQILV
VPAKLYFTEEEYLRELGLLNNRCIYI
>A0A256ZZB2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ex4484_178|TrEMBL
MLTFVGLGLYGTRDITLRGKDAVDKADYVFAEFYTSKLLGASVEDLEKFFGKKITLLSRE
EVEKGKILIESASKGNTVLLVAGDPMVATTHVSLKILAEERGIKTEVIHNSSIITAAPGM
LGLQHYKFGRIVSIPFPQANYFPTSVYDFLAQNMKMGLHTLLLLDINPRPMTANEGMEIL
LKMEEKKKLGIINGDTLIAVVARAGAPDAAVKAGYMKDMLKENFGPPLHTLVIPGKLHFA
EAEALVKLAHAPKDILEE
>A0A7M4A061|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MALAPSKHLGGLSMAANETHVDSLPKTGLLLIGMGLGRMEGMTLEALEAATLADHRRYEA
YTALWPEAELARLEAKVGPIQRVMRPEVEDPTELLELAASSLVALLVVGDPLQATTHVDL
QLRAAEAGVSCRVLHGVSITTLVTGAVGLSNYKFGRQTTFTYPYGNWIATSPLEVVASNW
SQNLHSLVLLDLDPTGQGIGDQRPMTPADAVRSLGMMWHSMQTNEDDGSAEDAPATAFQR
SMQTDFLEQSMEAMQVVLCSDMGTPEQSIVATTVGALSDETGGRLNCLIFPASTGEVEEK
ALARWRRGE
>A0A3A5WHT8|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTVDLPPSGLLLVGLGPGGLGGMTLAALEAAQKAEHRWYEAYTALWPDEDLADLEARIGP
IERVMRPDVEHPTRMFELAQTSLVALLVVGDPLQATTHVDLQLRALEAGIPCHVLHGLSI
TGMVTGAAGLSNYRFGRQTTLTYPHGSWIATSPLETVAVNRHQGLHTLVLLDLDPTGAGT
GDQRPMRPEDAHRSLHLMAERLNERAASDAPEVERNAAALSDLDVGAWPVVLCADVGTVD
EAFVTTTVDGLPSETGGRLNCLLIPATVEGVEAEAIARWRRA
>A0A897NG09|diphthine synthase|EC 2.1.1.98|Halapricum desulfuricans|TrEMBL
MLTFVGLGLYDERSITLQGRDALQAADRVFAERYTSRLVGASLEDVEVAHDVEIELRTRE
GVEQDPEPILTAAENGDAVFCTAGDPMISTTHVDLRLRAHERGIDTRIVHGTTAAAAASS
LTGLQNYRFGKATTLPFESSHGGDGVPDSVIETIEANRERGLHTLVFLDIKVDDDREDYM
TGGEAASLLAADWNGTAPAVVVARAGSPEPLVRGDRLEELAGTDFGDPLHLLVIPGKLHY
VERDALVELAGLPAEAAERLLV
>A0A835XEA9|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFVGIGLSGPESISIETQKLLGQVDIVYLEQFTSPISKSNLIKIKKLVKGEFKIAKRW
QVEDGKEILKNAKRKKVVLLSYGDPYIATTHIELRTRAILEKIKTATIHAASSITSLVGE
CGLHYYKVGKIITIMKEFQTLTTVYFTIYQNMVAGNHTVLLLEYNQDAQYFLDPKDAFSA
LLDTEKEQKRRVIKPSTFAIVASRIGFKNQKIFAGKISSLKKLNFGKPPHSIIIPGLLHF
TESDALKVLAKCVDEPIDNSSEIKKISKQMIEKYVPMVKKELEEITPYFKKSKEFQPVLE
NAQLYIQDAEKFLEQGRDEVAILSIGYADGLVDALRISKGFEPKI
>A0A7C5TAM8|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MLVFVGLGYSTRHLTMEAIEELRSADVIYVDTYTSMYEDPIIKVILELNPRAEVIVARRS
DLEGAAVNELIERSKTERVVVASPGDPFIATTHDAILADALRRDVKVKVVHGISFITMAF
SRLGLQVYKFGKTVTLVYPHSSKPYSVVDVIYDNLKRNLHTLVLLDLDIEKSRAMSIPEA
VDILLELDYLGFLKDRLALGIARLGWRDEKICAEVLPNLALKAFPPPPHSLVILARLDPV
EEFFIEYWRQSCR
>A8MC22|diphthine synthase|EC 2.1.1.98|Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)|TrEMBL
MNGVLYIVGIGLAPNQITQEAIEVLKNTGAVFIEEYTSMFEVKPSEYLTRIIGKPVTPVN
RRELEEENGSILIKAVKEYGSAALVTIGDPMIATTHSALLITAVEAGFSVKVINGISIVC
SAISQVGLSPYKLGPVATVTYERGGVLSRRAYEVLLSNISNGLHTLLLLDIKDGGGFMSI
KEAAEVLTRIEDEVKLGLVNDDLAAVFGSRIGWVDQAIKVTSITKPPDLKPPSIIVVPGL
LNPVELDLLKLVHGADEGLLKRHIEHVKSFLRNP
>M4YQF7|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon (strain BRNA1)|TrEMBL
MSSELIFIGLGLSGVDGMTVAALNALKNCDRIFGEFYTSSVIGVEVKDLEEAIGKKIEVV
YRSEVEEGHAIIDSAKECSTAFITAGDTMLATTHVDLRIQAQYEGIPVRIFNGISIFTAV
PTMFGLQPYKFGRAVTIPFLERNYQPKSPYDHIMENKKRGLHTLILLDIRAEELRYMTAK
EALEWLISGEEKWQEGLITDKTLMCVISHAGAPDQKIVAGYPKDLLEMDLGAPLQSLVLP
GNLHFMEAEALVDFADAPKEIIQDDD
>A0A1I0MNT2|diphthine synthase|EC 2.1.1.98|Halobacterium jilantaiense|TrEMBL
MLTFVGLGLYDERSVTVEGRDAIAAADRAFAEFYTSRLVGAGVDDLEDYHDTTIEVRDRA
GVEQNPEPILDAAEDGDAVFLTAGDTMISTTHVDLRLRAADRGIETRVVHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADGVPASVVETVEANRERGLHTLVYLDIKVDHPSVDGD
AYMTASEAAGLLAEHWDPDALGVVVARAGAPDATVRADRLGALAESDFGDPLHLLVVPGD
LHHVEADALAGLAGAPEDAL
>A0A7C4H7P7|diphthine synthase|EC 2.1.1.98|Thermofilum pendens|TrEMBL
MLVIAGIGLYGLRDLPLGVIEIARGADRIYLEQYTSLAPGFSLEALEELFGKHVEEVARQ
DLEEQSGRELLEQARKSTVLLLTFGHPLIATTHTSLVVEARKAGIPVKILPAPSVFDGVI
CSTGLHVYRFGRPVTLVFPERGRKIYPYTTYAVIRDNLRRGLHTLLLLEIRRQEGVYMDV
ATAAALLLELEEVFHEHVISEDTLAIGVARATAPDEVVKVGELRELAGEDFGPPPHSVVI
PGVLHDSEIEFLSSVHGAPVEVMINWNKHVKKRLESTFEP
>A0A3N5NH73|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon|TrEMBL
MLTFVGLGLFDKTDISLKGLACIQEADYVFLEIYTSCLMGSTVGELEEYYKKPLHRLFRE
DVEQHPDRLLELAKTGQVVFLCAGDPMVSTTHADLRIRAAERGISTKIVHAASIASAVCG
LSGLQNYRFGKSCSLPFPQKNWFPTTPFDVIQQNLDCRLHTIVYLDIQKDRFMTIPGAVV
LLEQMAREKQRAVPLYVGVARAGSDDAIVRAGPAEKILAEEFGPPLHILVIPAELHDMER
RYLELFAGL
>A0A3M6JWP4|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPISKSDLTKIKKATKGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKDKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALSG
LLETEKGQRRKVISSSTFAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNADKTRKISVQMIEKYVPMVREALEEVQPYYKDQKEYEVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>M0CTU1|diphthine synthase|EC 2.1.1.98|Halogeometricum pallidum JCM 14848|TrEMBL
MLTFIGLGLYDERSITVEGRDALADADRAFAEFYTSHLVGATVEDLESYHGIDVEVRDRA
GVEQNPEDILDAAEDGHVAFLTAGDTMISTTHVDLRLRAVERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPKSVTDSIEANRERGLHTLVYLDIKADREEYMTG
DYAAEMLAEGWEDVLGVVVARAGSESPLVAADRLSALAERDFGDPLHMLVIPGDVHHVEA
DALRALGGAPDDIVEENEA
>A0A841HD30|diphthine synthase|EC 2.1.1.98|Halobacterium salinarum|TrEMBL
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHIERDALRELAGAPADAL
>A0A8M1N3B4|diphthine synthase|EC 2.1.1.98|Danio rerio|TrEMBL
MLYLVGLGLGDAKDITVKGLEIIRKCSRVYLEAYTSILTVGKDALEEYYGRELLLADRDM
VEQEADEILKGADVCDVAFLVVGDPFGATTHSDLVLRALNAGIQYRVIHNASIMNAVGCC
GLQLYNFGETVSIVFWTDTWRPESFYDKIKKNRDMGLHTLCLLDIKVKEQSMENLMRGRK
IYEPPRYMTVAQAAEQLLEILQNRRDRGEELAMTEDTVCVGLARVGAEDQTIRSGTLREL
ASCDLEGPLHSLIISGHLHPLEVDMLKLFSSPEGLKSLKMTDSSTYVS
>A0A2R6F7R4|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_8_64_26|TrEMBL
MLTFVGLGLYDERSITIEGREAIDSADRVFAEFYTSTLAGTTVADLEAFHDAAIEVRDRA
GTESDPEPVLSAARERSTAFLVGGDPMISTTHVDLRLRATEEGIDTHVVHGTTAQAAASS
LTGLQNYRFGKATTLPFAYGSGGVPESVLRVIAENRERGLHTLCYLDIEAEREAYMSADD
AASRLADAIESTNQSDTGDTGSEPLAVGIARAGSSESLVRADRLSALASTDFGDPLHLLV
IPGDLHHLEAEALETLAGAPEGLV
>A0A7J9S4U3|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISEETKVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>A0A2H9LG91|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG07_land_8_20_14_0_80_44_23|TrEMBL
MALYLIGIGLYDEEDITLRGLSLAKDSDYIYLEGYTSLSSATIEGLEKKTGKKIEKKERE
FFEQGSKSIIALAKKKNVGILVIGDPLSATTHIDLLNEAREAGVKAEIVNNASIINAIGI
TGLQPYKFGKITSIPYPQGGYMPETPYNILKENLSINAHTLLLLDLSPKDGKFMTANEAI
EYMLSLEEKKKAGIFTKDTLVIGCARIGSRSPTIKAGKAGKLLSEDFGNPLHCIIIPAKM
HFVEEENIRKWMIK
>A0A2K3J3D7|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon M11B2D|TrEMBL
MKKNSKAHLVFIGLGLYDEADISLKGLQELKKCDKVFAEFYTTILGTFDRESFEERIGKK
IDVLSREETEKADKIIDAASQNHVAFLTGGDPMIATTHVDLRLRAMKQGIPTTIIHSGSI
VTAVPGLLGLQNYKFGRTTTLAFPEKTYFPTSPYTVIYNNRNLGLHTLVLLDIQAEKNHY
MTANQGFEVLLTMEEKLKKNLLTPDTLACVVARAGAENPMVVANTIGKLQKKTYGPPLHT
IVIPGDLHFMEIEALELCAGLPSEIKRKIQKL
>A0A5D5AKY5|diphthine synthase|EC 2.1.1.98|Natrialba swarupiae|TrEMBL
MLTFIGLGLYDERSITVEGQRALREADRAYAEFYTSKLIGASVPDLEDVHGIEIEVRDRA
GVEQHPEDVLEAAENEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDDNRADGLHTVVYLDIKVGYDPTSSQ
TANRPEDTVGYDRADGDQYMTADVGAALLAEEYPELVGVVVARAGSPDPLVDAATMTELA
ERSFGDPLHLLVIPGECHLLEADALVELAGVDREALDIV
>A2BJ42|diphthine synthase|EC 2.1.1.98|Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)|TrEMBL
MPLYLVGAGISARYLTLRAIQLIGSADVVYIDTYTSIAPGIDEELVTRLNPRARIVKASR
ELLEQGSRRIVEEAQRMNVVVLVPGDPLHATTHIALLLEARRAGVDAEVVPGVSGLQAVV
DATGLQVYRFGRPVTLVYPEEGFKPYSTIDVVRNNRRAGLHTMVLLDLRLDEGRAMTVPE
AVELLLSLEEELAHEEGWEPELRDAVIVGVARAGLEDGVCIAGRPEEVASASYPPPPHTL
VVTAPRLHPMEAEALKTLCGCKSC
>A0A7K3YLT6|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon|TrEMBL
MELVFVGLGLNDEKGITIKGLEEINSADHVFMETYTSRMPDFNMGHFKSMCGKNVQMINR
QCLEEDSGKIILTAAKSGKAVFLVPGDPFIATTHITLRVEAEKLGIKTRVVHGVSIMSAI
VSLSGLHNYKFGKTVTVPFADNFSETPYNVVGQNKKLGLHTLCLMDLREAENRYLSINEG
INVLLEVEKKKKMGILTERTPALGIARAGSDNPVLKADFVNKLVSYDFGEPPFSLIIPGE
LHFMEVDALIAFAEAPKEFRGLSK
>M0PI09|diphthine synthase|EC 2.1.1.98|Halorubrum aidingense JCM 13560|TrEMBL
MLTFIGLGLYDERSISVEGREALRAADRVFAEFYTSRLVGATVDDLEAYHDVEIEVRPRE
GVEQDPGAILDAAAEGDAVFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPQSVIDTVEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAALLAEGWRDELAVVIARAGSPDAVVAADRLSALAERDFGDPLHLLVI
PGDLHHVEADALVGLAGAPTELVGE
>A0A656YWG1|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA259J03|TrEMBL
GLAGLQSYKFGKTATLPLPEKRSITPYDVLEDNKKQGLHTLFLLDIEKEEERYLTADRAI
EYLLDLEEELERKVYTGDTLSVVVARAGSEDPLVKADRCGNLIGRGFGRPPHILIVPGKL
HFLEAEALEYFADAPKEVVEEYVKE
>A0A2I0NYL3|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon HGW-Methanomicrobiales-4|TrEMBL
MLTFVGLGLFDLDDISLKGLMAIQDADYVYLEAYTSRMMGTDHGAMEDRYGKPVQILMRD
EVEQHPDSILEKSRDQNVVFLTGGDPMVSTTHADIRIRAAEQGISTRIIHGASISSAVSG
LSGLQNYRFGKSCSVPYPAKNWFPKTSFETISKNLISGLHTIVYLDIQENRYMQIREAVE
ILEILAQEEETTIPLYVGIARAGSPKPVVCAGTAEKMLSFDFGPPLHILVVPASLHPVEE
EYLHIFASL
>A0A832URH5|diphthine synthase|EC 2.1.1.98|Candidatus Naiadarchaeum limnaeum|TrEMBL
MIKLIGLGLWNEKSMSLEALEEAKDCDVLYVEFYTSRLTGLKNISELENQIGKEIKVLNR
EQFEGKTKNFLQEAREKNIGILVAGDALTATTHIDLLIEAKKGGIEFRVVHGSSIYTAAA
GLSGLQIYKFGRATSIPFFKAESPYDILAENKKAGLHTLIFLDIQNENLMSANEAMKKLI
EIEKKKKKKVFTENTEIVIVARAGSENPLVKFGKVKELLKEDFGGPMHVLIVPGKLHFKE
REALELNKF
>A0A662P8C4|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MLYLIGLGLRGDDIPYSGIKALKKCSKVYCEVYTNLPGIEKKKLESILGKKINFLERKDV
EEKDFIVEEAEKENIGFLVSGDPLAATTHIDLVLRAKKRNIDVKIIHASSIFSAVSETGL
QLYKFGKTVSIVYPEEKFFPKSFYDTIISNKERGLHTLLLLDIKAENKRYMNPNEAFEIL
ETVDKNKIIKKVIVVSRLGRDDQKIIYGDINELKSCSYGDPPHCIILPGELHFLEEEFLN
YFKVKK
>A0A832VRG7|diphthine synthase|EC 2.1.1.98|Thermococcaceae archaeon|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTDIRKIEEQIGKPIRLLNR
EDVELNFERIVLSEAKTKNVAFLTAGDPMVATTHADLRIRAKQMGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKENKERGLHTLLFLDIKADKGRYMTANE
AMEILLQVEEKKKEGVFTEDTFVVVLARAGSLNPTLKAGYVRDMMKEDFGKQPHVLIVPG
KLHIVEAEYLVAFANAPKQILNEV
>A0A127B8S9|diphthine synthase|EC 2.1.1.98|Pyrococcus kukulkanii|TrEMBL
MALYFIGLGLYDEKDITLKGLEIARKCDYVFAEFYTSLMAGTTLERIQELIGKKIKVLSR
EDVEINFERIVLPLAKDSDVAFLTAGDPMVATTHSELRIRAKKMGVKSYVIHAPSIYSAI
AVTGLHIYKFGKSATVAYPEGNWFPTSYYDVIKENKERGLHTLLFLDIKADQGRYMTANE
AMELLLKIEDMKKQNAFTEDTLVVVLARAGSLEPTLKAGFVRDMIREDFGKQPHVLIVPG
KLHIVEAEYLVEIAGAPEEVLKLAR
>A0A7V3NDF6|diphthine synthase|EC 2.1.1.98|bacterium|TrEMBL
FIFMFYIVGIGLEKEDISLKALEALKRCEEIYIEKYTTPLPYSIKEYRKFISKILNKKII
IKEAKRSLLEENSEEFIKKAKNKNIALLVYGDPLIATTHIALIKEARKKGIKYKIIHNCS
VFNAIADFGLSMYKFGKIASMPKWEKGYEPESFYKIIEENKSIDAHTLLLIDPNLNFNDC
IKQLKKVDREKKIKDFFVCSMLGTKNQKVFKFNLEKIKIKEIKKIKEIKKPFCFIIPSSL
SFYEN
>A0A2E8EG61|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MWQHLSLPPQGEIELTLTLISIGLTDHTDLSQRALQAARGCDILYAELYTMILDTNIDLL
SEAIGKKVIELPRGRMEDSSYTLIEEARQGDIGVLVGGDALTATTHVSLILEATHEGIPT
RVVHGSSIITAVAEAGLSPYKFGRTVTLPLPNKAPPDTVLTTLRENREYGLHTLILLDLD
TVNKKAHTIKGAIKILLNADQPETYRGETLTVGIARLGWTDQEIKADFAKAFAGHDLKKP
PHALIIPGRLHFHEIEALRTLAACPEKALELHNPVGELDRLIKKYSESCRRVIQEFNTED
LPRSVTLERVKALTLHAANYLDDGEYYQAERKATALASVSYAEGILDTLRLLGLVEFKW
>A0A7J2JY35|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVGSLTFIGLGLHDEEGMTLRGLAAARKADAVFLELYTSLMPGLSLSRLEELVGKPLRLV
DRKVLEDLDAEPLMEEALSGRDVALLVPGDPMVATTHVAVRLRAEELGIRTRVIHAPSII
SAVVGLTGLQAYKFGRTTTITYREAGLLSEAPYRAIAENSAR
>A0A7J2LE79|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MITIIGFGIRPKHMSLEALEVLKRADKVFLEAYTNVFPSSFVEELKRIIGTDDITLLKRE
ALENNLDKFIEESRSKHVALLIQGDPMFATTHINIILECKKKGIPCKVLSGISIYNRILA
VTGLQPYRFGRLVSIPLLSKNFMPSSPYLKIAENMRSNLHTLVLLEAVSDTEFLSINDAI
DYLLKMESRFRMKVISDNRFAIGVARLDYDEGIIKCDKVLRLREIEFGSPPHALILLADC
LHFLEAEALIELLSAPIEVKRLVK
>A0A550GH22|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRFEKLKGLTFVGLGLNDETGLSYRGLEETRNADSVFIELYTSLLPEFSLKRFETLAGKT
VELLSRRDLEEANGETILEAAKRGCVVFLVPGDPFVATTHVALRIEAEKRGIKTRIVPGA
SAISAIIGLSGLHNYKFGKTVTVPFPGTLSETPYNVIAENRMRGLHTLCLLDLKADEHRF
LSVNEGLQALMVVERKIRKGVVTSGSLAVGAARVGGVNPTLRADWIGELLKYDFGGPPQS
LIFPGELHFMEVEALIRFAGAPEKLRGAVK
>A0A7J2TKR6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVFVGLGLHDEKGISLRGLEEIKTADAAFMELYTSLLPNFSKKRLEKTSGKKLRVVSRKE
LEEENGKVIIEVAEEGKAVLLVPGDPLIATTHVALRIHAEKLGIETRIVHGASILSAVIG
LCGLHNYKFGKSVTIPFLEETPSETPYEVIAQNKKLGLHTLCLLDIKTEEKRYLSIAESL
EWLLKIEKKRKEKIITPNSLIVGVARAGSKKPTVKAGFLRELMNYDFGKPPHSIVFPGKL
HFMEAEALVVLAGASDKVREMVE
>A0A0E3RX58|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei C16|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A0E3P491|diphthine synthase|EC 2.1.1.98|Methanosarcina siciliae T4/M|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLFRE
DVEQQPTWLDEAKDKNVVFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARIISETPYDTIKKNSELGLHTMVFLDIDKDKGYMTV
NHALELLLEVENRRGEGIMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVKLASGPEEIMEETE
>A0A0Q4BER9|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon RumEn M1|TrEMBL
MMGHLIFVGLGLSRPQDMSVRALRALRECDEVFAEFYTSRLIDATAEELEEFIGRPVTVL
RRAEVEEGDVIIEAARRGRAAFMVAGDPMSATTHVDLRLRAVEEGIDTELVHGVSIFTAA
AAAFGLQPYKFGRAVTIPFPEPGYLPSSPYENILENRSRGLHTLVLLDIREEEGRYMTAA
EAVRWLMDAEERLKGGLLDEETVLCAGARVGSSNQSLLAGPPSLLAATDMGPPLHCVIVP
GRLHFMEARALVRLAGAPERILQD
>A0A7C5GSP4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MKKLSLIGMGIVNERSIPLLGLDRLKEADLIFAELFTSILEEGSLERLSQLAGKEIRLLD
REDVEETEMVLGAFENADRICFLTAGDPLSATTHQEMRLDAEKRGVEVEIINAASIFTAA
PGISGLQQYKFGRTTTLAFPEEGFFPTSPLDVIESNLERGLHSLVLLDIQAHRDRYMSAP
EGAALLLRMVEKKGGSPIGPETMMVAVARAGHHDRKLVYSSLGKLSNMSLGPPPHCLIIP
GKLHFLEEEVLDSFRVE
>A0A534K1U8|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFVGLGLFDEKDITLKGLDAARAADSVFAEFYTSSLRGTTVATLELMIGKAIKSLT
RKDIEQGSEILDAARRGSVALLIPGDPMSATTHVALRLRAIDAGIETRIVHGPSIVSAAA
GVLGLQSYKFGRATTVPFTGDTFRPASPLDVIEENRKRGLHTLVLLDIKEDGEFLTAGKA
IEYLLELAAERKSDAFTADTLVCAVGQVGSDRPRVAAGRAK
>A0A534K1S6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELIFIGLGLDDEKGVTLRGLDEAQSSDLVFAERYTSGLSDTSLDAIEKLVGKGVHRLT
RKEVEDGEVILTAAVRGKVAFLIPGDPMAATTHVDLRLRAASRKIPTRIVHGVSILTAAA
GALGLQIYKFGRTTTVPFSSAGFEPTSPLEAILTNRRAGLHSLVLLDLREDGSFLAPRDA
IASLLKMASSLESSEFGPDLLAAVLSRVGSPHVRAFAGPIARLAARDLGPPPHCIIVPGS
LHFLEKEALVAFAGAPHDL
>L0HLZ9|diphthine synthase|EC 2.1.1.98|Aciduliprofundum sp. (strain MAR08-339)|TrEMBL
MLTFVGLGLGGLEDITLRGKGAIENADVVFAEFYTSKLINADIEDLERFYGKRIILLGRD
DVEDGKIIMNEAQNKNVVLLVAGDPMIATTHVALRIMAQEFGIETRVIHNASIISVAPGL
LGLQNYKFGRTVSIPFPQENFFPTSAYDHIMENLRMGLHTLILLDINPRPMSANEAMQIL
LEMEKVRGKGIISEDTIIAVVARAGSEDALVRAGKIKHLIKEDFGPPLHTLVLPGKLHFA
EAEALVKLAGAPEEILD
>M0C4R1|diphthine synthase|EC 2.1.1.98|Haloterrigena limicola JCM 13563|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSQLIGTTIEDLESSHDLEIEVRDRA
GVEQHPEDMLEAAEDEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPFAHGAEGLPASVTETIDENRADGLHTVVYLDIKAEREEYMTA
DVGAELLAEEYPDLVGVVVARAGSPEPLVEAGTMTELAQREFGDPLHLLVIPGECHLLEA
DALVELAGADRETLDIV
>A0A2R6IIJ8|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_4_69_31|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIAAADRIVAEFYTSKLAGATVADLESFHGVDIEVRDRA
GVERSPEDVLADAEADDVVFLTAGDTMISTTHVDLRLRAHDRGIETRVVHGTTAQAAASA
LTGLQNYRFGKATTLPFERSHGGEGVPGSVVETVEQNRERGLHTLVFLDIDAQHDAYMRA
DGAAEALAGAWRDGLGVAVVRAGGPDPVVRAARLSTLATESFGDPLHLLVVPGDLHHVER
DALAALGGAPQELLE
>A0A497JHD1|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MMLIICGIGLKPKHITLEAVERLKECDRIFIEAYTSYFAEGSAKDLEKITGKKIFPLYRE
DLEGNLENFLDMAKRNKIALLILGNVFSATTHMQIYYEAKKKGIKTEILPGISILNFVGK
TGLEEYKFGRIVSIPFWQQNYKPKSFYAYIKNNISSALHTLCLLDLRISKEEKRFMTINE
ALEILRKVDEEKILSNRLCIAMCGVSSAAEEIVAERFEDLSRKDFSKKAFPQCLIICAEL
NEKEKEFVGLLG
>A0A6B2CCT8|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MFILSGLGQNKDEIPYGLIEEIKSADLIFLEYYTNFIDEETKEFLLNIRKDINIVDRNFV
ELELEKIILNNRDKKIILITSGNPLFATTHMYFIELCKKNNIEFKIINSPSIFDEIGKIG
LFLYKFGRTVSISFHESTEFYDYIIRNYKNNLHTLVLLDLDPINNKYLDHKEAIKRLLEI
DNKREKIFSENFKLIVCSNLNRKNEKIYYKEIKELLNINLDPPLCIIIPSNLNKIELEFL
LCMIS
>A0A101XDI5|diphthine synthase|EC 2.1.1.98|Vulcanisaeta sp. MG_3|TrEMBL
MGKKNPTLYLVGLGLSPGNLTIDALNIIRSVDKVFMETYTSKAPGELIKQIMGIRHDIVF
LSREDLEDRSGNAIISELSKGRNAALLVIGDPMMATAHAAILVIAKRLGFEVRVINSVSI
VCAILSQLGLSPYKLGPIATITYPRMGILSMRAYEILNDNLRRGLHTILLLDIKDGNEFM
SAGEAIDLLRKMEENGKLGIINNDLLVIYAARIGWENQSIVVSTINNVPSLGETPHTIII
PGLLNPVEIDYLTYVLNADKDLVLKHQRWVNKLMNGNWQK
>F8AIW6|diphthine synthase|EC 2.1.1.98|Pyrococcus yayanosii (strain CH1 / JCM 16557)|TrEMBL
MALYFIGLGLYDESDITLKGIETARKCDYIFAEFYTSLMAGTTLERIERLIGKPIRVLSR
EEVELHFEDIVLPKAKEGDVAFLTAGDPMVATTHAELRIRAKQMGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTLLFLDIKAEQNRYMRANE
AMEILLRVEEMKKGGVFTPDTLVVILARAGSLNPTLRAGYVKDLIGEDFGSPPHVLIVPG
RLHIVEAEYLVAFAGAPEEILEKRL
>A0A256XYM3|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon ex4484_78|TrEMBL
MLYLVGLGIGGCKAITLQGLGAVKQCDKVYLEVYTSFFDSVSELENLVGKKIFVVGRDFV
ESGDVILSEAKDNNVAFLVVGDPLCATTHWDLLRRAKENNIPVEVVHNASIVSSVGSTGL
QVYKFGKITSIPFSDSEVIVETPYNVLKENLSIGAHTLFLLDLRPDENRFMSVHDAVEHL
LKIEKLKKENLFNEDTFCIGCARIGFSDEFIKAGKARELLNVDFGRPVHCLIVPGKLHFM
EEEALRLFQ
>A0A6A9SA09|diphthine synthase|EC 2.1.1.98|Haloarcula sp. CBA1122|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A4U7EAG6|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SP9|TrEMBL
MLTFIGLGLYDERSVTVEGRAALREADRVFAEFYTSRLVGADVSALEAHHGVDIEVRDRA
GVERDPEPIFEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDGVPASVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLAEEWGDALGVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVGE
>A0A256XRJ0|diphthine synthase|EC 2.1.1.98|Thermofilum sp. ex4484_82|TrEMBL
MLIFVGLGLHDLQDLTFHGFSVLKKAKKIYMETYTNIMPDFSRERLETLIGQEIVEVSRE
FLESDKISQIIEEASKEDIVLLVPGDPFIATTHITVRIEAEKRGVKTMVVHAPSIISSAI
SECGLQIYKFGKIATIVYPEPELGFFPFSVYEVLKENLSRRLHTFFLLDLKVETGKLMTI
SDAIDVLFMMEEKLNEGVVTSDTLGVGLARVGSPNTILKAGSLAELKSYNFGPPPHSLII
PSILHPIEAEALIFLCNANKKLIEKWTRKIG
>A0A482SAG6|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MVFYLIGLGLGDHRDITVRGLESVKKCTHLYLEYYTSVLGVDKAALEAFYGKEIVVADRE
FVESKAEEIYMQAKESNIALLVVGDPLCATTHVDIILRAKKEGIKVEVIHNASVMGAVAS
CGLQLYQFGYTVSIPWFEEGWTPSSFYERIQYNSKGGMHTLCLLDIKVKEPDYESLMKFG
KIRYMPPRFMTVSTHACFVLFVHSNSA
>A0A7J3R9R5|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLIGIGLNEKSISLEGLDALKKCKDVYLDSYTSCLPYEIKKLEKVISKKIFLVDRNFL
ESNRLIEEARKKNVALLVYGDLFFATTHVSLLLNADKNRIKIKMIHSFSVFDAISETGLQ
SYKFGKISSIPKWEKNFEPCSFVDYIHENFLIKAHSLILIDPKLNFVESLNQLKIAMEKK
LKINKDLKLVVCSKLTTPDSKIYYGFMEDLIKKSKEIEHPFCLIIPSELHFVEEEFLKKF
EV
>A0A662FW12|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MIRIGELAFIGLGLCGCDYLSIKALRYLKNADHIFLETYTSILPNFSREKLEKLLGKRII
EIKRRDLEEKEGEDIIRLATRKRVALITPGDPFIATTHNFLRLKALKMGIKVLTIFGVSV
VSAAQSATGLHCYKFGRVCTLVIPEERYGYFPETPYIVLTQNLKYGLHTLFLLDLKIEEE
KYLTPQEAIDLLLKLEEKIKLKAISENTVAVVLARLGCNSQAVVCNTLKRLRKIDFGPPP
YCLIIPGKLHPLEKESLILLAGAPPEIFED
>A0A2H4VFY7|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. MZ-A1|TrEMBL
MLYLVGLGLYDEKDISLNGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINILRRE
EVEEDNLPIKQAENNDVAFLTAGDPLMATTHSDILMEARRNGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEQNYFPHSPYHVIGENKKMGLHTLVLLDIQAHRDYYMTANEGL
EYLLRVEEERREEIIEEDTLAVVIARAGSPEPLVRADRVDKLTEEDFGGPLHCIMIPGDL
HFLEAEGLVVLGNAPEFILEED
>A0A0D5ZIS0|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLNIIGLGLRGTKSITLESFEVMKSCDSVYFETYTSISPGSTMADLRNALGRKLLEAGRD
FIESEKDIIDESRDTKVCLLVTGDPLSATTHNQLRLDAMKAGVEVRIFENSSIISVIPGV
FGLMHYRFGPPVSIPFVSRSFFPTSVYDKIEKNISMDLHTLLLLDLKDGKTMPVQEAVRI
LEELERRRKGRILEPERDICVAIAVSQPGQRLVFGTMGSIKKSGVEGNPAALVLPSTLND
SEETFLNEFAERL
>A0A256HHK2|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Eb13|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVDELEAYHDVEIEVRPRE
GVERDPEAILSAAAEGDVAFCTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKMGTGPTGPD
PDHEEYMTADVAAGLLADGWRDELAVVVARAGSPEPVVAADRLSALSEREFGDPLHLLVI
PGDLHHVEADALAGLAGAPPELVEE
>A0A5Q0UGR6|diphthine synthase|EC 2.1.1.98|Candidatus Nanohalobium constans|TrEMBL
MIHLIGLGLDNKEATEKGLEAIKSADKAYAEFYTNTETINLERIEEKTDSSIQKLSRKEV
EQEDKILEEAKDSDVAFLVSGDALTATTHYDIKHRAEEKEIETEVVHAPSIFTSIAETGL
NVYKFGRTVTLPENGKPDSVIKYVEKNDEIGLHSLILLDINLEASEAAEKILEMKPEFSK
REALVLERANLETQEISRMTLEEVSEKEFGEPPHCLILPGEKSHKEEEFLTRWRDW
>A0A564QC22|diphthine synthase|EC 2.1.1.98|Candidatus Syntrophoarchaeum sp. GoM_oil|TrEMBL
MLTFVGLGLYDEKDITVRGLEAVKSAHIVYFERYTSRLGDCTREGLGKAFSRDIHVANRE
DIENDPEEILKRAESDDVVLLTGGDPMTATTHIDLRLRAYDRGIETHVIHAPSIFTAVSG
ITGLSSYRFGKTATIAYPYKDRVDLISDVPYDTIKLNRLNGLHTLLLLDIAADEYMKIPQ
ALRILESLEERRKEGLLDDLLFVGIARAGSDDMVVKAGKCRVLKNFEFGEPLHVLVAVGE
LHFMEEEALFKFAALKGGL
>A0A147K3G6|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon YNP_N21|TrEMBL
MLVFVGLGLRGIDGMSLQALREIKESEVVYAEFYTSAIPGLKISELERLVGKGIKIVSRE
IVEHHPDGIIRDALNKKVAFLVPGDPMVATTHVDLRLRAAKAGVVTKIVHGTSIVSAAAG
ISGLQSYKFGRSATIPFPDNPSQTPYEVLAENKKRGLHTLFLLDIRAEQNKIMSANEAIE
ILLGLEEKLGEKVFTPSTLAVVIARAGSDDSIVVADSAASLLRMDFREPPHVLIVPGRLH
FVEKEALGIFASAPPEAL
>A0A3A6Q968|diphthine synthase|EC 2.1.1.98|Halonotius pteroides|TrEMBL
MLTFIGLGLYDEGSITREGETALRAADRVFAEFYTSRLLGADVDDLEVHHGIEIEVRDRA
GVEQDPEPILQAAADGDVAFLTAGDTMISTTHADLRVRAADRGIDTRVIHGVTAETAASG
LTGLQNYRFGKAVTLPFPGLHGSGDVPPSVVDSIDANRERGLHTLVYLDIKIDSHRELSA
LDTDDPYMRADHAAGLLATDWEDELAVVVARAGSPEPVVAADRLSVLAERSFGDPLHLLV
IPGELHHVEADALEALAGTPVPHLPTESDR
>A0A3A4UN31|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLIGLGLSDADDISLKGLNAIKSCSKLYLEWYTSKLQCSVEDLEKVYGKKIHLANREF
VENASELLDEAMIGDVALLVMGDPLCATTHWDILTRAEKLNIRTKVIHNASIVSAIGAVG
LQVYKFGKTTSVPFPRENYEPESFYEVIRQNKSVGAHTLLLLDLWPQEGRFMSVNEAIEL
VRKVERKRGEKVFQSSDWCVGVARIGAKDQKIVAGTAVEVSDVDFGTAPHALIIPGQLHF
MEEEAVARWKKS
>A0A7J2NF72|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MPLYLIGLGLCPEHISVKGKDFITTSDYVFIESYTSLFSEGAITQLEEECAKKFSLCGRE
LAEQNSGKILSLAKESRVSFLVVGDVFSATTHSSLFLDARKNNIDVKVVNNASVLTAVGI
TGLSLYKFGAPASIVYPEPGFFPATPYYSLEKNLSLGFHTLFLLDIKQDKGIYMTIKDAV
DILLKLESKEGKKILSPNLMAVGCARLGSDKPSIAYAELVKLQEFGFGEPPHCLIIPSAL
HFMEEEILGLYSLEKQGK
>A0A1M5JDH2|diphthine synthase|EC 2.1.1.98|Halobaculum gomorrense|TrEMBL
MLTFIGLGLWNERSVTVEGREALRVADRVFAEFYTSRLAGTTVEALEAHHGADIEVRDRA
GVEQDPSAILDAAEDGEIAFCTAGDTMISTTHVDLRVRAAERSIDTRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFEYAHGAEGTPQSVIDGIEANRERGLHTLVYLDIKVAGSSPAGP
AEGESDEYMTADHAAAALARDWDEDAVGVAVARAGSPEPVVAADALGVLGEREFGEPLHM
LVIPGELHHLEAEALATLAGCPRDVLPSFE
>A0A0E3NCN0|diphthine synthase|EC 2.1.1.98|Methanosarcina thermophila (strain ATCC 43570 / DSM 1825 / OCM 12 / VKM B-1830 / TM-1)|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTSLERMEKLYGKKVFLLSRE
DVEQHPDWLSEARNKKLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGRSASIPHPYESGRGTRVISETPYDIIKQNLELGLHTLVFLDIDQEKGYMTV
NTALELLLEVEEKRGEGVISGAAAVGIARAGSEKPVVKADYVENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAGAPIGFMKEAE
>A0A384K9C9|diphthine synthase|EC 2.1.1.98|Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)|TrEMBL
MLTFIGLGLYDERSVPVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A662L479|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MTLKFIGLGLHDGRGISMRGIEEARKCDVVYAEFYTTPMPELDVEWIQGVIGRKIKVLKR
EDVEEGKCIIRDAMERDVALLVGGDPMAATTHLSLRIEAMKRGIKTVVVHSESIFTAAAS
AAGLQHYKFGRTITIPWVRDNYFPMSPYDMLARNRAEGKHTLVLLDTEPKDGQIMRACDA
VEILLMMEEAGRKGVFSKDTRIFALARVGSTEPFVIFGRAERIMEASMPEPPHTIIVPGE
MHFMEEEFANLVAID
>A0A7J4S884|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGELIFIGLGLHDERGITLRGLEEARAADVVFAEFYTSALLGTKAAAIESLLGRTVRRLS
REQVEGGKDVLDAAKDHRVAFLVAGDPMV
>A0A7C1E3P9|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLTFVGLGLYSERDITLAGLEAARSCDTCFAEFYTSALGVSLEEVEKMLGRAVVPLSREE
VEEGSVILGGAERESVCLLTGGDPMTATTHVDLRLRAVERGIATRVIHGVSISTAAAGLL
GLQSYKFGRATTLVTPQENYFPTSPYEVIRDNKQRGLHTLVLLDIHQHAARYMTANQGID
VLLEMERRMSQEVIMDKTLLAVVARASSPSPVVKAGYPPELRRGDFGPPLHTLVVPGHLH
PMEARALVLLAGAPSELLG
>A0A7C1B3K5|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MKKGELVFIGLGLYDEKDISLKGVELVKKCDKIFAEFYTSVLTDDCIEKLEEMIGKKIEV
LNREEVEDGRVILEHAMDKKVAFLVGGDPLSATTHVDLRIRAKKQGVDTKIIHGSSIFTA
IPGLLGLQHYKFGRVTTLMFPHGDFFPKSPYEIIYENKSRGLHTLVLLDIDRENNRFMSA
NEGMKLLFDMEESLGKNLINDNLLVCVVARAGSDNPVVKAGRIKRLIREDFGSPLHTLVV
PGNLHFMEVEALISFAGLEKDELG
>M0C7W4|diphthine synthase|EC 2.1.1.98|Haloterrigena salina JCM 13891|TrEMBL
MLTFIGLGLYDEQSITVEGRDALQNADRAYAEFYTSKLLGATAADLEAAHDVDIEVRDRT
GVEQHPDDILEAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDANREDGLHTVVYLDIKVDHELTDED
EYMTADVGAELLAEAYPDLVGVVVARAGSPDPLVAAGTMSELAEREFGDPLHLLVVPGEC
HALEADALVELADANRDALETN
>A0A1V5AZD9|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaU1.Bin055|TrEMBL
MLSFVGLGLYDERDVSVKGLQTIMDADLVYAEFYTSRLMGATPEKLARFYGKEIQLLSRE
EVEVSPEDWMGRAKEEKVAFLVGGDPMISTTHLDLRLRALRMGIKTRIVHSSSIVTAASG
LVGLQNYRFGRSTSIPYPYVAGGRRIVAMSPRDVVVENLARDLHTLLFLDIQPERYMTAG
EGAALLLEMEAAAGADRLNSSLGVGVARAGSEDAVVVADWLPRLPERDLGDPLQILIVPA
RLHFMEAEALVALAGAPPEILEVAEP
>A0A7C1FYI2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MAKGELVFIGIGLHDEKDISLKGLEAAKSCDEVFAEFYTSTIPASCISKLERLIEKPIQV
LERKEVEEGKIILDSAMERKVGFLVVGDPMAATTHVSLRVSAEKRGIKTKLIHSSSVFTA
IPGLLGLQHYKFGRTTSLVYPQDSYFPLSPYSVIEENLSRGLHTLVLLDINREKGMYMSI
REGIELLFDMEEKVGHGVIKEDMLMCGVARAGSDNPLVRAAPARILKGIDFGPPLHTIVI
PGQLHFVEEEALQVLAGYQKRR
>A0A660QX09|diphthine synthase|EC 2.1.1.98|Thermotogae bacterium|TrEMBL
MPGELVFIGAGLSRNDITLKALSVAKSCDIIFAEEYTSRLSDCSMEELETIIGKKINVLR
REEVEEEEIPIKHALTKKVAFIVAGDPMTATTHISLRIEAEKKGIKTKVIPGVSIYTAVP
SILGLQHYKFGRTTTLVYPEKNFFPLSPYYVIKENMERGLHTLVLLDINAEKNRLMTVRE
AIDILLEMESRAKNNVIREDTLACAVARAGAEDSIARAGTMKTLREENLGKPPHTMVIPG
ELHFTEKEALETLCGYREM
>A0A0D8DP45|diphthine synthase|EC 2.1.1.98|Acidiplasma sp. MBA-1|TrEMBL
MLNIIGIGLRGYKSITLEQLDAIKNSDIVYFETYTSISPENTFDYLRSITGKKLIKADRN
TVESSNEIIKNALNSNVSFIVTGDALTATTHNELRLEAIKNGIDVKIFENASIFTAFPSR
TGLFNYRFGPVISLPFIYENFFPLSVYDKIYKNYVNDFHTLILLDLKNGQTMEINEALDI
LIKMEEKRNGNIINYDTFIIAGFNIAREDEYIIAGHIKDVINKKISMSPASIILPAKLND
KEIEFVKIFCDNV
>A0A151F7Q4|diphthine synthase|EC 2.1.1.98|Theionarchaea archaeon DG-70|TrEMBL
MLYVIGLGLNGDLTLEGVKTAKKCRIYLEVYTSFLTVSVEDLEQVLQREITVLTREDVEE
SQKFLEEAKTRDVALLVIGDPLIATTHAEIVIEARKQNIKTKIIHNASIYSAIAETGLQI
YKFGKTITIPYPQKGFQPTSFYDTLQKNNRMGAHTLVLLDIKEDRKMYMKPREAMEILHG
LKFEGDIICVSRLGCPDQCIVYGNIKELLLPKDEYWGSPPHCLVIPSSLHFKEEEFLEAF
RGG
>A0A8G1A3F2|diphthine synthase|EC 2.1.1.98|Methanofollis formosanus|TrEMBL
MLTFIGLGLFDENDVSVKGLERIRRADHVFLECYTSVLTGTTIERMEEFFGKEVKTLGRD
DVEGHPEDFLGLAKDSDVAFLTAGDPMVSTTHIDLRIRAAGMGVRTEIIHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGKWAPKTPIEVIEHNMAENLHTLVYLDIQPDRYMRVPEAVA
LLEEMAAERGLSVPVYVGVARAGSAEPMVAAGTAGDLATVDFGGPLHILVVPADLHHMER
EYLETFAGL
>A0A101IHD9|diphthine synthase|EC 2.1.1.98|Methanothrix harundinacea|TrEMBL
MLSFVGLGLYDEKDVSVRGLETIREADMVYAEFYTSRLMGSSHEQLREFYGKEVRLLSRE
EVEVSPDEWMSNALDKKVAFLVGGDPMISTTHLDLRLRALKMGITTRIVHSSSIVTAVSG
TTGLQNYRFGRSTSIPYPYLAGGKRIVAQSPYEVVVDNLERNLHTLLFLDIQTDRFMTAG
EGAALLLEMERSAGRDRLAFSLGVGVARAGSEDAKVLADWLPRLAECDLGGPLHILVVPA
KLHFMEAEGLVALAGAPKEIQETAEP
>A0A537EUK0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVAFIGLGLNNERGLTIEGLEEARRSSNVFAEFYTNIMPGLDRRKLELLLGKRIVVLNR
FELEDEGGKQIVEAAERGRVAFLVPGDPMIATTHISIRLELAKKGIPSRIIHGPSIASAV
CGATGLQSYKFGKSVTLPQEPGVPGSLLDSVRDNKTRGLHTLILLDVKPELSKQLAIGEA
ATKLVTADPALGSWLGIGVARIGSEDQFVLSAKLGKLQNQDFGKIPHSLVIPGRLHFMEV
ESLKAFGGASDADLEALK
>A0A7J3VBP4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLVFVGLGLNGLEDITVSGMKWIRYAEKVYLDMYTSIIPNFSVENLEKNIVGRKVIKASR
KDLEENYEEILNEAKNKIIVLLVPGDPFVATTHMQLRLAAIDRGIETKVIHAPSIQSAIY
GETGLFSYKFGRCVTVTFPYGESICETPYDVIKENMKQGLHTLLLLDMDAENMRFMRISE
AIDILKRIEEKRRENVIKKDTLCVGCARIGSDTQVVRADYIDELSKVDFGAPPYSLVIVG
RLHFIEAEALVKLANAPLNVMEEVRCQIKK
>A0A367IGH9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPLCSRSLSFSRTITSCTDLFGTLRCRITFIMGNGSARFTMTAVSKGPGLWLIGLGPGDL
GHMTSYALQVAEACDKRYLEGYTAVLPSDQEEKLEEIVGKWDRVMRDDIENPEDILQQAQ
SSMIGIMVVGDPMQATTHIDLKIRCQESGVPFHIIPGLSATSLAVSLSGLQSYRFGRQVT
IPFPYGDYLPTSPLEMILTNHSNKLHTLVLLDLDPTGMGLAPPEPMLPEQAYEILESMIA
RLETSQDKEVASLIGPLSDWNAILLSDIGTVRQRVVSGSFSDISEIKGGGIHCLILPTEF
SGMEKEVFEHLKADM
>A0A8F5GXW0|diphthine synthase|EC 2.1.1.98|Saccharolobus shibatae|TrEMBL
MSILSLVGLGISKKFITESAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGEKTFIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNRERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVAVTVEEASSYDFGNTPHIIIIP
GNLHYMEADAIKWMLTS
>A0A843DY34|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilus sp|TrEMBL
MTSELIFVGLGLSGVDGMTVKAFNALKECDKIYAEFYTSHLIGTEIEDLEKALGKKIEVL
YRAQVEEDKELPAVIRDAKTMRVAFVTAGDTMLATTHVDLRIQAMYEGIPVRMFTGVSIF
TAAPAVFGLQPYKFGRTVTLPFLEQGYQPKSPYDHIMANKKLGLHTLILLDIRAEELRYM
TAKDAIEWLLAGEEKWQEGLITDKTLLCVVSHAGADDMKLVAGYPKDLLSMDLGSPLQSV
ILPGNLHFMEAEALVDFAGAPKEIIEDD
>A0A1H1C466|diphthine synthase|EC 2.1.1.98|Halopelagius longus|TrEMBL
MLTFIGLGLYDERSITVEGRDALREADRAYAEFYTSKLLGATVDELESHHGVDIEVLGRE
GVEQRPEEMLDAAETEDVAFLTAGDTMISTTHVDLRLRAVERGIETRVVHGVTAQSAASG
LSGLQNYRFGKAVTLPFPYAHGAEGVPQSVVDSIEANRERGLHTLVYLDIKADRDEYMTA
QFAAGELASDWKDVLGVVVARAGSPDPVVAADRLSALADREFGDPLHMLLVPGDLHHVEA
DAVRTLGGAPDDVVAENEL
>A0A1H9YNR0|diphthine synthase|EC 2.1.1.98|Methanococcoides vulcani|TrEMBL
MLDFVGLGLFDEKDISLKGLEKIHNADKVYVEFYTSILMGTDLEKMEELYQKKITVLSRE
DVEQHAEEWIADAKDMNVVFLTGGDTMVSTTHVDLRLRALDMGIETFLVHGASIASAICG
LSGLQNYRFGKAATVPHPYVTSRGSRVISETPYDTIKMNMENGLHTAVFLDIDKDKGYMT
VNEALEILLEVEEKRGEGVMADRISVGIARAGSPSPVVKADYAQALKSFDFGEPLHILII
PASLHFVEAEALVKLAGAPDEILEDMD
>A0A832XVM3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTGSGAARFTMTDDGLAPGLWLIGIGPGDLDHMTERARGVARGCSKRYLEGYTAVLPPKE
EGRLESVVGPWEKLMRDEVEGAEELLASARGESVALLVVGDPMQATTHIDLEDRCVEQGI
GFHVIPGLSATALAVSLSGMQSYRFGRQVTLPFATSDYLPTSPLKMLCNNFENGLHSLVL
LDLDPTGMGLEQPRPMSPAEAVGLLEKMAERLVDEEDGRRGRLELPVKQWNGILLSDLGT
EEERVLSGHLGDLSGQKGGMVHAFILPAEFSGMEKDAFERRRTT
>A0A6V8CEA4|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPLIVTTGQDGISMTVDLPPTGLLLVGLGPGGRSGMTAAAIEAAQTADHRWYEAYTALWP
EQDVIDLEAHVGPIERVMRPDVEHPTEMFELARTSLVALLVVGDPLQATTHVDLQLRAED
AGVPCRVLHGLSITGMVTGAAGLSNYRFGRQTTLTYPHGAWIATSPLETIALNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHMMAERLAERPPEEGALSSLTSAALEGLDVGA
WTVVLCADVGTSDEAFVTTTVDGLPSEVGGRLNCLLVPAAIEGVEAAAIARWRRS
>A0A6V8EQP2|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MLMTGRHTPRFTMTDGALPAGLWLIGLGPGDLGLMTADAIEHARACEHRFLEGYTATLPS
DQESRLESLIGPWQRAMRPQVENPAEILELARTSSVALLVVGDPMQATTHIDLEAHCDEQ
SIEFSVIPGLSATSLAVSLSGLQSYRFGRQVTLPFAYGDYLPTSPLELIDANYRSDLHTL
VLLDLDPTGMGVNQPQPMSPFQAVELLQKMAVRLAEREGESRDSMSTPIAQWDSILLSDL
GTPDQRVVSGHLEDIAKAEGGRIHCLILPAEFSGLEREAYERRKGQR
>A0A662T9P1|diphthine synthase|EC 2.1.1.98|Candidatus Geothermarchaeota archaeon|TrEMBL
MLILVGFGISGFKGISLEGLEAIKEADKVYLEAYTSPVGLSVRELEEIIGKEVSLLSRRD
LEESTRILDESIDKKVVVLTPGDPLIATTHVSLVLEAKKRGIDVKVIHAASIYTVAMGES
GLQAYKFGRMATLTVPDEFVPLSVYEVIVDNKRRGLHTLLLLQQDISSGEFLSVKEALSL
LVKMEDIKKEGAVSKDTIAIVLANLGFSDQVKVAGRIKNLMRFFQNFPPKPAVIIIPGKL
HFMEKEAIMNMWIDEDER
>A0A897N055|diphthine synthase|EC 2.1.1.98|Halapricum desulfuricans|TrEMBL
MLTFVGLGLYDERSITLQGRDALQAADRVFAERYTSRLVGASLEDVEAAHDVEIELRTRE
GVEQDPEPILTAAENGDAVFCTAGDPMISTTHVDLRLRAHERGIDTRIVHGTTAAAAASS
LTGLQNYRFGKATTLPFESSHGGEGVPASVIETIEDNRERGLHTLVFLDIKVDDDREDYM
TGGEAASLLAADWNETAPAVVVARAGSPEPLVRGDRLEELAGTDFGDPLHLLVIPGELHY
LERDALVELAGLPAEAAERLLV
>E3GYW7|diphthine synthase|EC 2.1.1.98|Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)|TrEMBL
MVGLGLYDEKDISVKGYNILRKVDKVFAEFYTSKLFGTNIEKLENFFGRKIEVLERKEVE
EEMIPVKEAKSKNVAFLVPGDPLIATTHQSLIIEAKKLDIDVEIIHSSSILSAAPGITGL
QAYRFGKTTTIPFPEDGYFPHSPYLTIKKNLENEAHTLVLLDIKSDENKYMTANEGLEYL
LKVEKERKEGIINNDRVVIVLARIGSHNPVIKVGRVSEMINENFGKPLHCLVIPASLHFM
EYEYLTTVLGAKKEILEDIV
>A0A7J3XET3|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLISLGLFSVEDMSLRALEVARKCECLFLEQYTTGLEFDIDRLSKLVGRPIKIVSRCD
LEEGLQTILELAKNTDVGILVGGDALTATTHITIILEAKKQGIESKVIHGSSIYTAVAET
GLQIYKFGRSTTLPKFKAISPYEVIETNRKLGWHTLVLLDIGMTAKEGLELLLELEREQR
RNVISDDLEVVVCCRLGSEDAVIKYGKICDLLRLKEIDRYPAVIIVPGELHFVELEALER
YRI
>A0A256KMF5|diphthine synthase|EC 2.1.1.98|Halorubrum distributum|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKSTTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A8J8BKU9|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeota archaeon|TrEMBL
MLYLIGLGLYDEKDLSLRALEILKGCDEVYVELYTGVFQGSAEKLEELTARPVRILFRKD
LEENPEGNVLMNSRNMHIALLVPGDPLVATTHIDLILRARKLGIETKVIHSSSIYSAIGE
TGLQLYKFGKTTTLAFPEKGYFPTSPYDVIKENLAKGLHTLVLLDVKAEEKRFMTVKDAI
ELLLDIEHSKKEGVFTPNRACIGAARIGGDSVIKAGTAEDLRKEKFGDPPHIIIVPGKLH
FVEEEALEMYGLKG
>A0A256IBQ2|diphthine synthase|EC 2.1.1.98|Halorubrum halodurans|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSRLVGADVADLEAAHDVDIEVRDRE
GVERDPEPILAAAEAGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGGDDVPGSVRETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADYAAGLLADGWRDALAVVVARAGSPNAVVAADRLSALAGREFGDPLHLLVI
PGDLHHVEAEALVGLAGAPESILE
>A0A2R6GJW1|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_4_69_225|TrEMBL
MLTLVGLGLYDERSITVRGRDALRAADRVFAEFYTSTLAGATVADLEAEHGVEIEVRDRE
GVERNPEPILAAAEAGDAVFLTAGDTMISTTHVDLRLRTARRGIDTRVVHGTTAEAAAAS
LCGLQNYRFGKATTLPFPWAHGGEGVPDSVVETVERNRERGLHTLVFLDIKVGTGPSGPD
PDFEEYMTADRAAGLLADEVGGVAVAVARAGGPDPVVVADELSALAGRSFGAPLHLLVVP
GDLHVVERDALAELVDGPADVLPDPV
>A0A843AX73|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccus sp|TrEMBL
MGELIFVGLGMSRPEDMSVRALTVLRNCDEIFAEFYTSKLNDASPKELEAFIGKKITVLK
RADVEEKGIIVEAARKGKVAFISAGDPMSATTHVDLRLRAIEQGVSTDIINGVSIFISCS
SALGLQPYKFGRTVTIPFPEPRFLPSSPYDNILENYSRGLHTLILLDIKEEEGRYMTAPM
AMRWLLDAEERLGKGLVKERSLFCAAARVGSARQALFAGYPDEVKAVDLGPPLHCMVMPG
RLHFMEARALVTLANAPRDILEDQGA
>A0A6G1YSH9|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLRFIGLGINGHKTMSTHVLEILRNCNAIYLDKFTGFVSDDDLKELRSLAELHDFEINIL
PAERWFVEDGRDILEQARTSDLVLLTYGDPFIATTLIELYVRAVKNSIKVDVIHAASGIT
SLIGEAGLHIYKFGRIVTITSEPLSTVSVYNAIFENLLGRNHTLILTEYDNEHGKLFFLN
PNSAFNTLLQAEKDFRFKVFFEDTFAIVASRIGMPDQKIVSGTVRSLNGIDFGQGPHSII
ITGALHFVEVEALMTLTHNLNEPLDNTANMQNLSAGMVARYAPKAREALSKLKRISSTDN
GISGNKINIEILANAECYIDDAERFLRQGKPELAVLSIGYAEGLIDAMRVNKGIDP
>A0A7L4P0P3|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
MLYLIGLGLYDEQDVSLKGVEALKKADVIYAEFYTSRLFQGSIKSLEYKLGVQINVLKRE
EVEEENIPLKVAQDKDVAFVCAGDPLIATTHTDLMIQARKRDIETTVIHSSSILTAAPGL
AGLQAYKFGKVTTIPFTEENYFPHSPYLAIRKNLEEKLHSLVLLDIQAHRDRYMTANQGL
EYLLQVEEKRNEGIITGDTLAVVVARAGAEKPVVRADIISKLVDEDFGGPLHCLIIPSDL
HFMEAEALVVLGGAPERILSNPL
>A0A6G2K931|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0662_bin_33|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A4WHH8|diphthine synthase|EC 2.1.1.98|Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)|TrEMBL
MLYLVGVGPGPGYVTEAAAKALADADCVFYEDYTGPLHLETIRRYAKTEPIRLTRRDLED
ESGRAILQCLEKGGRAVLATAGDPMLATAHAAVVAAARRRGHRVEVVPGVSIICAAMSAG
CLSVYKLGGVATVTYPRGGVYSRRPYELAEQNIKRGMHTLLLLDVKEDGSFMPPRDAAAV
LLELERLEGKGVFKPETPAVLVHRLGWGGGAKYTNLAQIAASDYEGPAVIIIPGVLGPVE
EECLQTLR
>A0A285NDU8|diphthine synthase|EC 2.1.1.98|Natronoarchaeum philippinense|TrEMBL
MLTFVGLGLYDERSITVEGRDALRDADRAFAEFYTSKLVGATVEELESHHDIEIEVRDRA
GVEQDPDPILDAAAEGDAVFLTAGDTMVSTTHVDLRLRAHERGIDTQVVHGVTAQSAASG
LTGLQNYRFGKATTLPFEYAHGAEGVPDSVVETISANRERGLHTLVYLDIKAEREEYMTA
DIAAEQFAEEFGEELGVVVARAGSPDPLVAADRIDALAERSFGDPLHLLVIPGDLHHIEA
DALGALGDAPEDLLDPV
>A0A832RUX3|diphthine synthase|EC 2.1.1.98|Methermicoccus shengliensis|TrEMBL
MLTFVGLGLFDEHDITLKGLRAVQQADEVYAEFYTSRLCGASIEQLEALYGKKVHVLSRE
DIEGHPTFIERARELDVVLLSGGDPMVSTTHVDLRLRAHRMGIATRIVHAPSIVSAVCGL
TGLQNYRFGRSATVPFPYEHGERRMVYESPYDVVRENLERNLHTLLYMDIQNGRFMRASE
GAALLLEVAQRRGDEGLSSRLGVAIARAGSEDCVVRAAPLEDIASMELGPPLHVLVVPAE
LHFMEAEALVEFAKAPRHILEG
>A0A6B0GL39|diphthine synthase|EC 2.1.1.98|Halomarina oriensis|TrEMBL
MLTFVGLGLWDERSVTLEGRETLAAADRVFAEFYTSRLMGSSLDQLETFHDCDVEVRDRA
GVEQNPDPILDAAEDVDVVFFTAGDTMISTTHVDLRMRAEARGIETRVVHGTTAEAAASS
LTGLQNYRFGKATTLPFPFVHSRESRRGSRASQNATRSDDGGDGVPDSVLDTIAANRERG
LHTLVFLDIKVRGSSTDRRNAELATDEREHEEFMSADYAADLLSGALPETLAVAVCRAGS
PDPLVAADRLDTLADRAFGGPLHLLVIPGDLHLLEADALRELADAPAALVEESTV
>A0A7C4B939|diphthine synthase|EC 2.1.1.98|Thermofilum pendens|TrEMBL
MLVVAGLGLYGTRDIPLGVLELLREADVIYLESYTSLAPSLNKEALEKLCGREVKEVKRE
DLEERSARELLAEAAERVVVLLTVGNPLLATTHTAIILEAKKRGIPFLIIPSASVIDGVI
CATGLHIYRFGRVVTLAFPDEERGFFPYSTYFAVKSNMSRGLHTLVLLDIRVEEGRYMDP
RCAAQLLLKLESMLSEDVLGENTLVIVVARATAPDQYVKVCTLDEAAQKDFGQPPFSMVI
PGLLHATEIEYLHHVHSAPLEVMLRWNMHVKKRFSSTLEV
>T1A4U7|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
MLYLIGAGIGESDISIGSIEVCRKASKVYYESYTSLISESKLRFISDNIGKNIEELTRGM
LEEESMRIVKEAKSSDIAIIFSGDPLIATTHKILFINATKEGVKVEVKHSSSIISAAIGE
SGLDFYRFGKVATISRWTDSYKPVSFYESIAANQSNNLHTLLLLDYMPESGSSMQLPEAL
RILIEAENHYGKGIISEGTKVFVMVNLGTDKQQKLYSSISELARSNIEKGPSCIILPAKL
SDIEEEIISSMFY
>T1CSI6|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
MSGHRGPELRALGRTLVCRPRAGQRAGPLRPGPRSAGRTPAIFAEEYTSLLAPGSIDRLE
VILGRSIGRLTREEFESERPILEALDGHSRVAILVVGDPFAATTHTALRVAAERAGHTWH
YVPNASILTAAASFLGLMHYRFGRTVSIPFPAPGYAPTSFLDGIRENRQRGLHTLVLLDL
RPAERTFLTAGEAIGILRERDAPGTALPPGTELAVVARIGTDDPAAGYGLPEVLIRIDFG
PPLHALVVPAGPLHEVEAAAVARFR
>A0A832S0Y4|diphthine synthase|EC 2.1.1.98|Methanosarcina sp|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTNPEKMEKLYGKKIHLLSRE
DVEQQPDWLNNATDKKIAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRKTKVISETPYDTIKQNSALGLHTLVFLDIDKEKGYMSV
NLALELLLEVERKRGEKVMDRAIAVGIARAGSEKPIIKAGYANDLINFDFGKPLHILVIP
GKLHFLEAEALVKLAGGPEEIMENIE
>A0A4D6KFC8|diphthine synthase|EC 2.1.1.98|Halomicrobium mukohataei|TrEMBL
MLTFVGLGLYDERSITVEGKEALQTATDIYAEFYTSKLIGTTIQKLEYYHDIDIELLDRA
AVEQTPDELLAAAEDGDVAFVTAGDTMVSTTHVDLRLRAEERGIHTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVETITANRERGLHTLVYLDIKVDDPHWEGE
QEFMTADHAAGLLADHFDTLGVVVARAGSANPVVEADSLDALADGDYGGPLHLLVVPADL
HEMERDALTTLADAPLAD
>A0A075I3U9|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_10_F12|TrEMBL
MHFTESDAINVLTKCLDKPSDNSSKIKNISVQMIEKYVPMVRKALEDIRPLYNDSKEFQE
VFENAELYINDAENFLKQGKDETAVLSIGYADGLVDALRIAKGIDPKM
>A0A7D5L8L5|diphthine synthase|EC 2.1.1.98|Halobaculum salinum|TrEMBL
MLTFVGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGASVADLEAYHGVGIEVRDRA
GVERDPEPILEAAESADVAFLTAGDTMISTTHVDLRMRAAERGVDTRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGAEGLPASVVDGIEDNRERGLHTLVYLDIKVAGSSPAGP
AEGEPDEFMTASEAAGMLAADWDPDAIGVAIARAGSPDPVVAADTLATLSERDFGAPLHM
LVVPGEVHHLEADALATLAGCPADVLPEF
>A0A1Q8BAZ3|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_20CM_2_51_8|TrEMBL
MPKVTFIGLGLDSEQGITLEGLDTARNASRVFAEFYTNLMPNLNLENLERLVGRKVTVLG
RRDIEDSEGKAVHAAASEGDVTLLVPGDPMVATTHVALRLSLAKRGFETRIIHSASIISA
VCGATGLQNYKFGRSVTLPAEPAVPKSVIQTLVENRQRDSHTLLFLDVRVEERTQIAIPE
ALQRLKKVLPESSDWLVVGLARVGASDQLVKAGSLNRLSKQSFGGPPQVMVFPSKLHFME
AKALKAFCGAEDTDLEGTA
>D2ZQ73|diphthine synthase|EC 2.1.1.98|Methanobrevibacter smithii DSM 2374|TrEMBL
MFLKSYTMFYLVGLGLFDAGDISLKGLECLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A2H9M5W1|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum sp. CG03_land_8_20_14_0_80_32_618|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>A0A218PBG3|diphthine synthase|EC 2.1.1.98|Thermococcus sp. P6|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCDLLFAEFYTSLMAGTTLDRIEGLIGKPIRRLSR
EEVELHFESIVLSEARERDVAFLTAGDPMVATTHSDLRLRARELGIESYVIHAPSIYSAI
AITGLQVYKFGKSATVSYPEKNWFPTSHYDVIRENGERGLHTMLFLDVKAEENRYMTANE
AMEILLRVEDMRKEKVFTPDTLVVVLARAGSLDPTLKAGYVRDMLGEDFGGQPHVMVVPG
RLHVVEAEYLVAFAGAPREILEDV
>A0A8J8EU65|diphthine synthase|EC 2.1.1.98|Thermococcus sp. GR5|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELQFERIVLSEAKGKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAI
AITGLQVYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGEGVFMPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGKQPHVMVVPG
RLHIVEAEYLVTFAGAPRKILDEV
>A0A7K4FKG0|diphthine synthase|EC 2.1.1.98|Ferroplasma acidiphilum|TrEMBL
MGLGLRGTKSLTLEEADALKESDLVYFEIYTSISPGNTVDSLSSLTGGMIRLADRNLIET
DSEIINEAKNKIVTLLVTGDALSATTHNELRMEAQKAGVEVKIFENASIITAFISKTGLF
NYKFGNIVSMPFIYENFFPVSVYDRIYINYSNNMHTLLLLDLKDGKTMGIQDALGILKRM
EDRQKKGLIEPERTVIAGIGIGSENESIIYGELDKVMEYNPPGSPASIIIPAIINDNERE
FLEAFARKIN
>M9SIK2|diphthine synthase|EC 2.1.1.98|Methanomethylophilus alvus (strain Mx1201)|TrEMBL
MTSELVFVGLGLSGVDGMTVKALNALKECDKIYAEFYTSNLIGTEVSDLAEFIGKEIHVV
YRSEVEEGHDIIEDAKTMRVAFVTAGDTMLATTHVDLRIQAVMEGIPVRVFNGISIFSAC
PTCLGLQPYKFGRTVTLPFLERNYQPKSPYDHIMENKKRGLHTMILLDIRAEELRYMTAK
DAIEWLLAGEEKWGEGLITDKTLLCVVSHAGAEDEKVVAGYPRDLLQMDLGAPLQTLVLP
GELHFMEAEALVDFAGAPEEIIQDDE
>A0A7L4PAX5|diphthine synthase|EC 2.1.1.98|Pyrobaculum arsenaticum|TrEMBL
MLYLVGVGPGPGYVTEAAAKALADADCVFYEDYTGPLHLETIRRYAKTEPIRLTRRDLED
ESGRAILQCLEKGGRAVLATAGDPMLATAHAAVVAAARRRGHRVEVVPGVSIICAAMSAG
CLSVYKLGGVATVTYPRGGVYSRRPYELAEQNIKRGMHTLLLLDVKEDGSFMPPRDAAAV
LLELERLEGKGVFKPETPAVLVHRLGWGGGAKYTNLAQIAASDYEGPAVIIIPGVLGPVE
EECLQTLR
>A0A1V4YN16|diphthine synthase|EC 2.1.1.98|Methanomethylovorans sp. PtaU1.Bin073|TrEMBL
MLTFIGLGLFDEKDISLKGLEAIAQANRVYVEFYTSRLMGTTVAKMEELYNKKITVLTRE
EVEQYPDWLGYARDENVVFLTGGDTMVSTTHVDLRLRAMEMAISTKLVHGSSISSAVCGL
TGLQNYRFGKAVTVPHPYTSSRGKTVISETPYDTILQNLDHGLHTLVFLDIDKEKGYMTV
NQALDLLLRVEENKDTKILQDRIAVGIARAGSDSPSVAADYIKSLKNFDFGGPLHILIIP
ADTHFVEAEALVQLAHAPKALLETQQQ
>A0A4P8JVT3|diphthine synthase|EC 2.1.1.98|Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLEDTLETSIERRDRA
GIEQDPEPILEAAESEHVVFCTAGDTMVSTTHADLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEES
DDTYMTASQAATMLSEPFPDTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPG
SLHPLEADTLESVAGAALE
>A0A2Z5PSC9|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis OS7|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISDETKVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>A8AA87|diphthine synthase|EC 2.1.1.98|Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)|TrEMBL
MKFVLAGAGLRCEHLNERVKRAILEAEEVWVDTYTSPFPGGLLNCVKGVREDALEADRSV
LEGPFRFSKSVTLVVPGDPMAATAHSALLLEARRRGYSVQIISNVSALQAARSKSGLSQY
RFGKVVTLMYPKEGISFTESVYNVIKDNDSMNLHTIVLLETGYGRDMTVPEAARLLCEYE
ELCDRRAIAMARLCWDDETIKVAKLRELAESDLGGPPHLLVFPSPKLHPIEEEFIEAVLK
>A0A257MAH3|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. ASP1-1|TrEMBL
MLTFIGLGLYDERDISVKGREAVAAADMVYAEFYTSRLMGTSLAGLEKFHGKKIHLLTRS
QVEVEPFWLEQAKEMDVAFLVGGDAMVSTTHLDLRLRAMLMGIKTRLIHSSSIVTAVSGL
SGLQNYRFGRSTTIPFPYLARGKRIVPETPYRVLQENLARNLHTMLFLDIQRDPVERYMT
AGQGAALLLEMESEAEDKLPPGTLGIGIARAGSDDAVIRADRLSRLKDCDLGGPLHILVV
PARLHFMEAEALRVLAAAPEDALMGAD
>A0A101X120|diphthine synthase|EC 2.1.1.98|Caldivirga sp. MG_3|TrEMBL
MAGTLYIVGVGLGPGQITQEAINVLRSVGEVFIEEYTSMFETSLGDHIAKVVGRMVVKLN
RRDLEEESGRVIINAIRERGSAALAVIGDPMLATTHSALVTQATQLGIRVRVINGISIVC
AAVSQAGLSLYKLGPVATVTYERGGVLSKRAYEVLVGNISRGLHTPLLLDIKDEGGFMSI
REAVDVLIRLEDEVKQGIVSDDLAAVFESRIGWSDQAVVVASLTNPPDLKPPSVILIPGL
LNPVEEEYLRVVHGAGEELLRRHINHVKALMRAMQHSSG
>M1IVR1|diphthine synthase|EC 2.1.1.98|Sulfolobus acidocaldarius N8|TrEMBL
MGVLKLIGLGLSYKFITEIALNELRTSDVVYADTYTSLTCGDLISRLHQLGINPIPVGRD
FIENNYKKILELLDQGKSVGIAVIGDPMIATTHISLVTEARTKGHQVSIIPGVSVHCYII
SKSMLSSYKFGKSVTIISSTDYGKIDTTPYKVLKENLERNLHTIFYLEPNMSARDAVSLL
LQMEKIEEQGIINEDSLIIVGQHLGCDDEEIVSLKIKEIAKYNLKSPPHIIIFPSKSLHY
MEIEGLKWLMK
>A0A1H7HCI3|diphthine synthase|EC 2.1.1.98|Haloferax larsenii|TrEMBL
MLTFIGLGLYDERSITVEGAEALEAADRAFAEFYTSHLVGASVSNLESYHDIDIEVRDRA
GVEQDPEEILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPFVHGGDPVPQSVVDSLEANRERGLHTLVYLDIKVEWEGRRGV
EIDDDEYMTADYAAELFAEHWDPDALGVAVCRAGSPNPVVAADRLEALAERDFGEPLHML
IIPGEVHHVEADALMALGGAPADRFDDF
>A0A842UE46|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MIILAGMGLHDIKDMPLKVLEAAQSCEKIYAEFYTNLYHSTLDELSNELGKTVTQVKRSD
LEEKLQTLVAEGAAKNTLILVPGDPLTATTHIELLLEAKKQGVETEIIHASSIYSAVAQT
GLQIYKFGKTTTLASPEQGYNPTTPYRVIAENKKHGMHTLVLLDVKAESGHYMTQKEGLK
QLLLMESKYRSGAVEPATQVISAARLGGCDQKIIYASAQKLKDTDLGSPPHVIIVPAQLH
FKEEEALNLYKP
>A0A371L5W4|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-47N|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A523AMY3|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MMLAFVGMGLCGQEGLSLRGLKVARESDWVYAEHYTSLLPELDLRRLEELVGKPVKLVDR
KTLEEEPEELLERAGRGRVTLLVPGDSMVATTHVDLRLRAERRGIPTLVVPSSSILSAAP
GLTGLQSYKFGRSATIPFRDNPSRVPYETLEENAKRGLHTLLLLDLRAEEGRYMLAGEGM
EIMLELEERMGRGVFTQDTLVVVLARAGCSDGRVRAGRVRVLRGEDFGPPPHSLVVPGRL
HFLEE
>A0A537DYN3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVAFIGLGLNDERGLTVEGLEEARRSSNVFAEFYTNIMPALDSKKLELLLEKRIVVLNR
FQLEDEGGKQIVEAAARGRVAFLVPGDPMIATTHISIRLELAKKGIPSRIIHGPSIVSAV
CGATGLQSYKFGKSVTLPQEPGVPGSLLESVRDNKTRGLHTLILLDVRPERSKQLTIGEA
AAKLVVADPALEQSVGIGVARIGSADQLVLSGRLGRLQREEFGSVPHSLVIPGRLHFMEA
ESLKAFCGASDEDLEALK
>A0A497NTD6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEVVFVGLGLHDDLGISLRGLEEVKSADEVFIELYTSFMPEFSIKRFEGFSGKRLRVVS
RKELEEEDGETVLRAAEKGKVVLLVPGDPLIATTHVALRMNAEKRGIKTRVVHGASVLSA
VIGLSGLHNYKFGKSVTIPFPSGAVSETPYDVIAQNRRLGLHTLCLLDVRAEEKRYMKVR
EGLDLLLKVEEKRKEGIVTFDTFAVGVARAGSSTPTVKAGFVRELLSYDFGMPPHSIVFP
GRLHFMEVEALVVLAGAPEKLRRMQR
>A0A537F9B1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MARVTFIGLGLDSEKGLSLEGLQEARRASSVFAEFYTNPMPNLNLQELETLLGKKVTILS
REQLEDENGREIILAAEKKDSVLLVPGDPLVSTTHVSVRLSLAERGINSRIIHAASIVTA
VCGATGLQNHKFGKSTTLPNSTLVPSSIIDTVLNNKDRGLHTLLLLDTDRGKGSSLSIGN
ALLLLGTVLSELDDWLVVGAARIGSPDEKVRAARGRELKAVAFGDTPHTIVIPSRLHFME
AEALKVFSGASDTDLEDYR
>A0A7J3ZQ29|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELIFIGLGLSDCFDISLRGLEEVKRADYVFAEFYTSFMPGFNPEEFRRISGKNLIIVS
RRNIEEEDGALILEKAKYGKTVFLVPGDPLIATTHIALRLKAEKIGIKTRVIHGSSILSA
AIGLSGLQNYRFGKSVTIPFPERGELSRTPYFVIAENKSRNLHTLCFLDIKVEESKYMTI
NDALKILLELEGRIRQNVVREENLAIGIARAGSENVIVKADAIGELMKFNFGGPPHTLII
PAEKLHFMEADALITLANAPEWVMEMIG
>A0A497M7E1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTLLKELVFIGLGLYDERDVSLRGLEEMKSADYIFIETYTSLMPNLSIERLERLCGKKLE
IVSRHELEEKNGEKILKAATKGKAVLLVPGDPLIATTHIALRIQAERMGIKTRIVHGASI
ISAAIGLSGLHNYKFGKSVTIPFPERDYLSETPYHVIWQNKQLGLHTLCLLDVKAEKKMF
MTIKQAIEVLQRLEKRIGKELISDMTLAVGIARAGSENCVVKAGTLKELKDYDFGGPPHT
LIFPGKLHFMEAEALKVLGGASEKIEGIN
>A0A7C3S4G9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFIGLGLYSYSDISLRGLDEVKGADYIFVELYTGFMPEFSIDAFKKITGKNLIVVS
RRNIEDEGGQIVLEKAAHGRAVLLVPGDPMIATTHIALRVKAERMGIKTRIVHGASILSA
AIGLSGLQNYRFGKSVTIPFPDGGIISQTPYNVIAENKMRNLHTLCFLDIRAEESRYMTI
KDALEILLRLEDVNKRGFLRKSELAVGIARAGAENPIVKADSMRDLLDFDFGGPPHILIM
PANKLHFMEAEALITLAKAPKWVMEMVG
>A0A550GK84|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKELVFVGLGLHDEKGISLQGIEESRTADQVFIELYTSILPCFSIQRFEAFVNKQIHVVS
RHDLEEEGGRVLLKAAEKGKAVFLIPGDPFIATTHIALRIEATKRGVKTRIVHGASVMSA
IIGLSGLHNYKFGKTVTIPFPENFSETPYNVIVQNKKLGLHTLCLLDIKTDEKRFLSINE
A
>A0A497NE36|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGRGTLTFVGLGLHDELGLTLRGLRAAREADVVFLELYTSLMPGLSLRRLEELVGKRLRL
VDRRVLE
>A0A151AGZ5|diphthine synthase|EC 2.1.1.98|Halalkalicoccus paucihalophilus|TrEMBL
MLTFIGLGLYDERSITVEGRDALQGADRAFMEQYTSRLIGTDVETLEAEHGIGIELRDRA
GVEQDPEEMLAAAESEDVAFLVVGDPMVSTTHVDLRLRAADRGIDTRIVHGTTAEAAASS
LTGLQNYRFGPATTLPFPYAHGAEGLPASVTNTIDDNRDRGLHTLVYLDIKQERGDYMTA
DIAADLLSEAYPDTLAVAVCRAGSPDPVVAADALSELAEREFGGPLHLLVVPGDLHHIEA
EALRTFADAPIELAPLE
>A0A830FWU1|diphthine synthase|EC 2.1.1.98|Haloarcula salaria|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDAYRVFAEFYTSRLIGTDIETLESSLGTSIEVRDRA
GIEQDPEPILEAAERENVVFCTAGDTMVSTTHTDLRLRAEDRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIKSNRDRDLHTLVYLDIKVDDPHWDDS
DDTYMTADQAATMLSEPFPDTLGVVVARAGSPDPLVVADTLDELATQTFGEPLHLLVIPG
SLHPLEADVLESLAGAAVE
>G0LGU5|diphthine synthase|EC 2.1.1.98|Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)|TrEMBL
MLTFIGLGLYDERSISIAGRDALQAADYVAAEFYTSYLVDATVSDLETAHDIDIDVRDRE
GVEQHPEDILRKAQSEDVAFLTAGDTMISTTHTDLRLRAIDRGIDTRVIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPYAHGAEGVPTSVTDSIAANRERGLHTVVYLDIKADRDEYLRA
SDAAEMLATDLEDMLAIAVARAGSPDPTVRADRLSALAEKDFGDPLHLLVLPGELHHLEE
EALAALADAPADMLNAVDSR
>A0A7K4BSH7|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLFDLGDISVKGLEYVRSADAVFLEAYTSRLMGTDVGAMEAFFRKEIRVLGRE
DVEQNPREILDRAAAGRVAFLTGGDPMVSTTHADLRLRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPMEAIAANLAQNLHTLVYLDIQKDRYMRVPEAIA
VLEEMAEKRGIEPPALYVGIARAGSEQPVVAAGTGAKLKETDFGPPLHILAVPADLHPME
REYLETFAGL
>A0A087RPY6|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote SCGC AAA799-D11|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLSKADMVYLEQFTSPISKSDLTKIKKATKGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LLETEKGQRRKVISSSTFAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNATKTRKISAQMIEKYVPMVREALEEVEPYYKDQKEYQVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A8J7REM5|diphthine synthase|EC 2.1.1.98|Methanofollis sp. W23|TrEMBL
MLTFIGLGLFDEHDVSVKGLEQIRRADYVFLESYTSVLTGTTLERMEDLFGKKIQTLARD
DVEGHPEDFLRLALDTDVAFLTAGDPMVSTTHIDLRIRAERMGVRTSIVHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGKWAPKTPIEVIEQNMAENLHTLVYLDIQPERYMRVPEAVV
LLEEMAAERGLSIPLYVGVARAGSPAPVVAAGNAADLAGVDFGGPLHILVVPAALHLMEQ
EYLKTFAGL
>A0A087S0G7|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote SCGC RSA3|TrEMBL
MEFNQDKDFFLDPKDALNGLLETEKGQRRKVISSSTFAIVASRIGFKDQEIVSGKISSLK
KRDFGKPPHTVIIPGRLHFTESDALKVLGECIDEPFDNATKTRKISAQMIEKYVPMVREA
LEEVEPYYKDQKEYQVILENAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGL
DPKM
>A0A7K4AGB1|diphthine synthase|EC 2.1.1.98|Methanothrix soehngenii|TrEMBL
MLHFVGLGLYDERDISLKGLEAVRAADCIYAEFYTSRLMGTTLEKMEALYGRKIHPLSRQ
EVEVDPSWLEEGRNKDIVFLSGGDAMVSTTHLDLRLRAIKMGIEASVIHSSSIVTAVSGL
CGLQNYRFGRSTTIPFPYVSRGRRIIPQTPYQVLRENQERNLHTMLFLDIQMEPVERYMT
ANEGTALLMEMEANAGESGLMEAIAVGIARAGAPDASVKADLLPRLQGYSLGGPLHILII
PARLHFMEAEALRILADAPADAVQC
>A0A6B2CK78|diphthine synthase|EC 2.1.1.98|Caldivirga sp|TrEMBL
MIGVLYIVGVGLGPGQITQEAINVLRSVGEVFIEEYTSMFETSLGDHIAKVVGRMVVKLS
RRDLEEESGRVIINAIRERGSAALAVIGDPMLATTHSALVTQATQLGIRVRVINGISIVC
AAVSQAGLSLYKLGPVATVTYERGGVLSKRAYEVLAGNISRGLHTPLLLDIKDEGGFMSI
REAVDVLIRLEDEVKQGIVSDDLAAVFESRIGWSDQAVVVASLTNPPDLKPPSVILIPGL
LNPVEEEYLRV
>A0A7J4ERY2|diphthine synthase|EC 2.1.1.98|Archaeoglobaceae archaeon|TrEMBL
MLVFIGIGLWDEKDITLKGYELAKEADEIFIEFYTSKLMGTTAEKIERMLGREIKILERS
DLEENSKIIVKKAAEKDIAILVPGDPVIATTHSAITLEARNMGVEVRVVHNASIITAVCG
LTGLHNYRFGKSASVSHPHGGKVSRAPIDVIRDNLCINAHTLLFLDLNPEPMTINQAIEI
LNIADEENILENCYAVGVARAGSENAFVRCDRLNVLKEVDFGEPLHTLVILAEKIHFTEF
EYLKEFAGAPEELKNNII
>A0A133VI84|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA382F02|TrEMBL
MLVFIGLGLTGNGITLKGLEELQKAEKAYAELYTSLIPELDLEKLESKIEKNIKVLQRED
VEQNPQEVLESAKKKKVAFLVPGDPMIATTHVDLRLRAEESGIETKIIHSVSIETAAPGL
AGLQSYKFGRSATLPFPDKPSETPYEVLEKNQDMGLHTLFLLDIEAEEEKYLTADQAIKT
LLELENKLGRKVFTKDTLTVVVGRAGSSDSIVKGGKVKDLVEEDFGAPPQVLIVPGNLHF
LEAEALEEFAKVPKEVVQENVEE
>M0AAT4|diphthine synthase|EC 2.1.1.98|Natrialba taiwanensis DSM 12281|TrEMBL
MLTFIGLGLYDERSITVEGRDALRDADRVYAEFYTSKLLGTTVPSLEAAHDIDIEVRDRA
GVEQHPEDILDTAKSEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGPATTLPFPYAHGADGLPASVTETIDENRADGLHTVVYLDIKVGHSPTSSQ
NPVGSDDKADRDDEDEEFMTADVGADLLAAAYPELVGVVVARAGSPDPLVEAGTMSELAD
REFGEPLHLLVIPGECHLLEADALVELAGAERNALDVV
>A0A662TS04|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
TGLQPYRFGRLVSIPLLSKNFMPSSPYLKIAENMRSNLHTLVLLEAVSDTEFLSINDAID
YLLKMESRFRMKVISDNRFAIGVARLDYDEGIIKCDKVLRLREIEFGSPPHALILLADCL
HFLEAEALIELLSAPIEVKRLVK
>A0A812EWF5|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotenuis uzonensis|TrEMBL
MLWFIGIGITGPDSLSLRARQIISECDIVYFEQFTSPIKEQNSHQIRSIVKGEFRLGPRW
LVEDGREILDAAQGKKVALLSYGDPYIATTHIELRVRAIREGIQTDTIHASSAITSLIGE
CGLHYYKVGRTVTIMSGIRPSTAYYTIFENLKLGSHTVVLLEYNQNSGFFLSPGEAFKSL
LEEEREQVRKVVSDSLYAIVASRIGFEDQKITAGKVSSLLDKDFGEAPHTIVIPGTLHFT
ESDALKALAECADMPEENTPKIEKISAQMMRKYVPMVRRALEQIAPHYSDAKEFAGVLEN
ADLYIRDAERFFEQGKDELAILSIGYADGLVDALRIAKGIEPEMNS
>A0A7J4F4D5|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MPRGKLSLVGLGLWPPRDLTIGGLAAARSADEAYIETYTSPLGLKVEELERLVERKLKPL
SREDLEDRAVLIERAAKFRTALLCPGDPLVATTHLALVLEASKRGIDVEVFNAPSIVTAA
FTRLGLHIYKLGAVTTITLGGLSERVAEQIQGATSRSLHSLLLLEADVASGRFVNPRRAL
SLLIEAGLVSEKSKVVVLCRLGWPSERIFFGEVADVASCDFGLPPHSVIILGPLHFTERD
ALDRFRVCGRGY
>A0A7J3CU31|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MANLYLVGLGLRDEKTLSLEALEILKKCQTIFFEDYTNFIKKDTFLNLEKILEKKLIRLS
RAELENEKLILNALNSGDCALVVPGEALIATTHHSLVLDAIKLNHKIKIIHSSSVVCAAI
SLSGLHVYKFGKICTIPFWHENYQPTSFLDTLKENNKIKAHSLCLLDLDENANPMPIKKA
IEIIFLAQKKRKLKLFNQNSKIIVLSKISWNDEVIWAGKIKDLKKDIFGPAVLIFPSKMH
FLEEEYFNFLKSYSF
>A0A497FDP9|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGKLVFIGLGLFTGDLPYRAVEVIRRADAVFIELYTTVLPQDYIEYLIKITGRSDFKILT
RSDLEDRGGEDVLEVAAKGLAVLLVGGDPFVATTHMALRVEAERRGIETEVIHSSSIISA
IAGATGLHVYKFGRCVTLVYPQPEVGYIPYSTYEVILENIERGLHTLVLLDYRHEEGRAM
TIPEAVSILLWLEERLGVEKSIRDRVAVGAARVGWSTEFVRADTLANLREVDFGAPPHVL
VITGDLHPTEVEALEVLCHLPRELAIKLLRRR
>A0A662IQ56|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MSNRQGNIKIEVNLFVCLTFIGIGLTGIDLTIEGLREAQNADYVFIDSYTSILPDGILNT
LSSLIGKEVKPLRRADLEGQGLARIMELAKRSRVALLVAGDPFIATTHITLKIEAAKAGI
PVKYKPSASIQTVIPGLTGLSSYKFGKSATIVFPDKGPNNVAYETVKDNKSRGLHTLLYL
DLEIESSRAMTINEGIKILLELEDEKGEGVISSDMLVVGIARACWEDNVIKASKLSKILH
YDFGPPPHVLIIPGSLHFMELEALKVFAGMEDY
>A0A369SYS1|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon NZ13-N|TrEMBL
MFILGGIGHNREEIPIGIVEKIKEADYVFLEGYTNFIDEDTLRYLRSLREDIIIVDRNFV
EGELEDFILKNRDKKIMLLVSGNPLFATTHAYFLKFCKDNNIEFKVIGSSSIFDEVGKTG
LFLYKFGKIVSIPFHESESFFEDIIVNYKNGMHTLILLDLDPISGKYLDLREALNRIINL
DRLKNTNMFSDKTEIVLCSNLGREGERIIYTDIKSAMNLNLNPPICIIIPGRLNEIEKEI
LKCMTSY
>A0A5E4K3Y7|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGLGLDESGISKSGLEAVKKCRKVYLENYTVNFPYPEKKIEKTIGKKIISVGREIV
EGNELIKEAKKGNICLLVYGSPLTATTHISLIQEAKKNKVKCKIICNASIFDAIAETGLQ
IYKFGKIASMPKWSKSYKPTSFMEIVKQNKEIDAHSLILIDIGLDLKDALEELEKSAEEY
GIKPEKILVCSRLGAKDSRIIYKEISQLKNAEIKKPYCIIIPSRLHFMESEVLEKF
>A0A7J3ENJ5|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MTLSFVGLGLGSMEYLTRGAEEALLSSEKVYLDTYTGYLSSELEAFLRSQLGERLIHADR
KKLEDGLHEIVDEAREKEIVIATAGDPFIATTHISILIEAVKKGVSVRLIHGVSIMSAAA
SYSGLSAYKFGKAVTIPRDASDQVLEGVYQVIAQNQEHGLHSLVLLDTADGGLGAGEAAE
YLLRTEEKIGHGVFKNDRIVVVLANVGLRTAQKMCHTLGELAMISLPPPPHVLIFPGDLN
FVEREALKLIAYCDKEMIDEYLPISTSRQRARRYIDKTSRVVERIGRESLDGVSREIIDL
ALTYVYDSQSFLSSGRVEDSLIAISYAEGLLDCLRMLGRVSFEW
>A0A0E3RUJ4|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei LYC|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A7J2HFM5|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MFVEKGMPLYLIGLGLGSRGYLTLKALEIMKRSDKIYLDSYTSFIGRDLLDELRKSFEGK
IVEADRRILEEGSSSILEEAEKMNVCILVPGDPLIATTHLSIILEAARKGVKSEIVYGVS
AYSALISASCLQAYKFGKTVTIPKSGVGIESCYRSIVENMERGLHTLILLDTADGGLEIP
AAIRMLSRVEEKLGMGLISERRLLVCLARIGFSDEFRWAGPLAQALKTSYPPPPHSIIFP
GSLHFSEAEALKEILGADPETVDSHLPLRYSWSRVSKYISSVDSVLTALKVLEDSSELRE
TLSLAKSYLEDSQRFQSEGRILDALAAISYAEGLLDGLRLLRKVEFSWRR
>A0A3N9V393|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLIFIGLGLYDERDISVKGLDAVRAADKVYAEFYTSRLMGASIEMLEALYGKKIHLLSRT
DVEGEPVWLEEARNKDVAFLVGGDAMVSTTHLDLRLRAAELGIKTVLIHSSSIVTAVSGL
CGLQNYRFGRSTTIPFPYVSRGKRIIPETPYLVLKENLARNLHTMLFLDIQCADSGERFM
TVNEGAALLLEMQDNAGEHILVDHLGVGIARAGAPDAVVKADRLSCLKSYDFGGPLHILL
VPAKLHFMEAKALVALAEAPADLAREE
>A0A496ZYZ7|diphthine synthase|EC 2.1.1.98|Chloroflexi bacterium|TrEMBL
MTMGELIFIGLGLWDENDITVKGLKEAKKCDCLFAEFYTSILGVEKEKLEKALGKEIRIL
NREEVEKGEIILNEARKKKVGFLTPGDPMSATTHVALCLRAIEMDIKTRVIHGISILTAA
AGLLG
>A0A497ASX5|diphthine synthase|EC 2.1.1.98|Chloroflexi bacterium|TrEMBL
VFIESYTSIVPGLNIEELIKMTKKDVKIVSRNILENLSGRPLLEEALREKKVVLLTPGDP
FIATTHISLRLTAHKMGIKTRVINAPSVLTAIFGATGLQVYKIGRIVTITFPYPEYNFYP
YSSIEKICENIKHGLHTIALLDLKVEEDRAMTVAEAAELLLKLGSQVCDEILDNNTPIIV
LARLGSDNELILTRRLGEVLNLNIGPPPHTLVIPGELHPLEIEALECFAHADRKVLESWN
LKIKNLKRKH
>A0A101DQI8|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon 41_258|TrEMBL
MLYIIGLGLYDENDISIKGMKTLKECDRIFAEFYTAKLKDQSLSTIKEKTGKDIQIIGRK
EIEEEMKPLKYAKREDVALLVPGDPLAATTHSTLILEAQRKNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEENYFPHSPYLTIKNNLKYDAHTLILLDIKAEENKYMNANQGL
KYLLKVEEERKENIISLDSLAVVLARVGSSNPLIRADRIKKLIVEDFGGPLHCLIIPSKL
HFLEAEYLIEIGRAPPEILEGRI
>A0A3M1DG48|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLHLIGLGLGDEHDISLRGLAIVRRADVIFLEHYTSTLGVDTKRLEQLYGREVKLADRT
IIEQRAEQLLEPAKKQDVALLVVGDPFGATTHTDLVLRAKDAGVTVNVVHNASIMNAVGV
VGLELYKYGRTTSIPYWSKGFEPETPYNAIKENSERGLHTLCLLDIKMEEKRPRFMTINE
ALGILEELERRRGERVVLPETLVVGVARLGQERQLIQAGPVSELRERDFGKPLHSLIVPG
DLHVVEEEALAQWR
>A0A842W4F8|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGLGIGDEKDISLKGLEAVKSCSNIYLENYTSVLQCSKENLEKLYGKKIILADRE
IVEKKPEHTILKHAKKENTAFLVVGDPMCATTHIDLMLRAKKENIPIKVIHNASIISAVG
ITGLEIYKFGKTTSIPFENKDVKAPYNVLIDNLEKGLHTLFLLDLNPKDKKFLTVKKAIK
YLEKQGLTKDTKILACSGIGSDYQTIKYGKPDILKDIDFKKPPYCLIIPAKLHFMEEEAL
KQYE
>A0A2J6GXP1|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYIIGLGLGDEKDITVKGLEAVKRCSKVFLEHYTSVLSSSVENLSKFYEKDIIIASRD
MVEKDADNILEDAKDKDVAFLVVGDVFGATTHTDIFLRAKEKNIDVKVIHNASIINVVGA
TGLELYKFGKTTSIVFDDDGWLPDTPYKVIKMNKTNGLHTLCLLDIKTAETSKKDMLKGK
DNPKDARFMTVKKACEILLKLEEKNKENLIDENLMVIGVARMGQETQKIIHASIKDFLES
VYMGEPLHSLIIPGNLHFVEEEFLEQYEIKEKLKKEN
>A0A2D6SNZ4|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGLGLNNEKDITVAGLEAVKKCDGVYLESYTSVLNCAKGDLEKFYGKKIISARRN
LVEGDDNEIIENAKTKNVAFLVIGDPMAATTHIDLYLRAKKEEIKCEVIHNASIISAVGV
TGLQLYKFGKVTSIPLENENVETPYDVLKDNLKSGLHTLFLLDLNPDEEKYMSVTDAIRY
LLKIELKRNERVFSERTLCVGCARIGSKDQVIKAGSAGALLKHDFGKPVHCLIVPGKMHF
MEEETLKLYS
>A0A662FGJ7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLVGIGLCNEKNLTLEAINAIKNCDEVFLENYTSVLQCKKEDLEKIIGKKINFADRNL
VESNTLVQKAKEKNIALLIIGDVFSATTHISLFIEAKKQNVEIRVINNASILTAIGITGL
ELYKFGRITSIPFHETDYPIKVLKENQQLGLHTLFLLDLNPENNRFLTIAEACDYLIRKG
ISPKTKALGCARIGCPDYKIVYADLNELKSIDFGKPPYCLI
>H3ZM65|diphthine synthase|EC 2.1.1.98|Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)|TrEMBL
MPIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTDIKKIEEQIGRPIRLLNR
EDVELNFERIVLSEAKTKDVAFLTAGDPMVATTHADLRIRAKQMGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKENKERGLHTLLFLDIKAAEGKYMTANE
AMEILLQVEEKKKDGVFTEDTFVVVLARAGSLNPTLKAGYVKDMIKEDFGKQPHVLIVPG
RLHIVEAEYLVAFADAPEQVLKEV
>A0A0Q0ZR70|diphthine synthase|EC 2.1.1.98|Methanolinea sp. SDB|TrEMBL
MLTFVGLGLYSLEDISIKGLGCIREADRVYLETYTSRIMGASIADMENFYQKPVIELGRE
DIEQHPGEILKEAERSDIVILTGGDPMVSTTHMDLRIRADRMGIQTAIIHGSSISSAACG
LSGLQNYRFGKSCSLPFPHKNWFPMTPIEVIKQNITLDLHTLVYLDIQTERYMTIPYAIG
LLEEMAKKAGIHITLYIGIARAGSELPVVAAGSADSIRRTDFGPPLHILIIPATLHVVER
EYLELFAGL
>A0A7J4QRW1|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MTAEHNIITGLPTTGLLLIGMGPGRLSAMSLEAVEAAKAADVRRYEAYTALWPRSELDAL
EAAVGSIEKVMRPEVEQPDVLFELARTSLVALLVVGDPLQATTHVDLQLQAAEAGIECRV
FHGVSITTLVTGAVGLSNYKFGRQTTLTYPYGGWVATSPLEVIAVNMHQNLHTLALLDLD
PTGEGVGHQVPMKPSDALVSLRLMWNKLGEMLDDLPRETALEAMRHEACAVFLARSLDDV
HVVLCADMGTDDERMVATTVGALDSIEGGRLNSLVFQSTASEVEERALLRWE
>A0A8J8A4G9|diphthine synthase|EC 2.1.1.98|Haloarcula sp. R1-2|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLEDTLETSIERRDRA
GIEQDPEPILEAAESEHVVFCTAGDTMVSTTHADLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEDS
DDTYMTASQAATMLSEPFPDTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPG
SLHPLEADTLESVAGAALE
>A0A142CTZ6|diphthine synthase|EC 2.1.1.98|Thermococcus peptonophilus|TrEMBL
MALYFIGLGLYDEKDITLKGLETARKCDKVFAEFYTSLLAGTTLEKIEELIGKPIIRLTR
EDVELNFERIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYIIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTLLFLDIKADQNRYMTANE
AMEILLKVEEMKGEGVFTPETLVVVLARAGSLEPTLRAGYVRELIKEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEEILEEV
>A0A5A7RT61|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGELIFVGLGLWSEKDITIAGREIAGECDTVFAEFYTSMLGVPKEKVEGVIGKKIEVLSR
EEVEDGSIILDEAVSRKVCLLTGGDPMTATTHVDLRLRAIERGIYTRVVHGISIITAAAG
LLGLQSYKFGRTTTLAFPEGDYFPTSPYNFIAENMERGLHTLVLLDIGDKFMTANEGIEL
LVEMEKRERKGIIGEKTLMAVVARASSPSPSVRAGYPDELLKEDFGPPLHCIVIPGKLHF
MEAKALVMLADAPEEIMK
>A0A7C2ALL3|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MSKGEIIFIGLGLYDEKDISVKGLEMARLCSKLFVEFYTSRLTGSSLQKLERYIGKPITV
LEREEVEKGDVILDAAEHRRVGFLTAGDVFAATTHVDLRLRAERRGVKTRVIHGSSVFTA
VPALLGLQHYKFGRTTTLVYPEGSYFPVSPYMVVKENLERGLHTLVLLDINKEAGRYMTI
SEGVDLLLKMAENSGSTLVGDDTLMCGVARAGSDAPVVKAGSAKTLKTFDFGPPLHTLVV
PGDLHFVEEEALRVFAGMR
>A0A7D5NW55|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon|TrEMBL
MGELIFVGLGLGSAKDMSIRALEELRSCEMIFGEFYTSRLVGSSIEDVEELVGKKVVRLK
RADVEEGEEMIVAARDHKVAFITAGDTMAATTHVDIRIRAEEGGVPTRLVHGTSIFSAAS
SALGLQPYKFGRTVTLPFPEPGYVPLSPYERILENKERGLHTLVLLDIREEEGRYMTSRE
AVRWLLDAETRAGLGLINDRTVICAAARIGGIDEKVAAGYPKKMLDLDMGPPLHTLVIPG
KLHFMESMALVMFAGAPEEIAKED
>A0A4V6E058|diphthine synthase|EC 2.1.1.98|Halorubrum sp. ARQ200|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLIGADVADLEAYHDVDIAVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYGHGGDDVPASVVETVEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADAAAELLAEGWADELAVAVARAGSPDAVVAADRLSALADRQFGDPLHLLVI
PGDLHHVEADALVGLADAPDALVEE
>A0A7R9N4V4|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon GB37|TrEMBL
MLTFIGLGLYDELDVSLRGLEAIRSADRVYAEFYTSRLTGTSVERLEELYSKKIHLLDRE
DVEGDPEWINDAIDHEVVFLTGGDAMVSTTHIDIRLRAERLGIKTKIIHGASIISAICGI
TGLQNYRFGRSTTIPHPYTTKSGKTMISETPYETIKQNRENDLHTLIFLDIDKEKGCMSI
GEGIKLLLRVEMERNEGIISEETLGVGVARAGSPTQVVRADYLGELEEVDFGAPLHTLCI
PASLHPIEAEALVAFADAPREILQKRE
>A0A133UL42|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA259E19|TrEMBL
MLAFVGLGLSGDGITLQGLEEVRSADEVYAELYTSLIPGFDLEELEKKVGQPIEVLQRED
VEEKPAEILKEAKDEKVVFLVPGDPMVATTHLDLRLRAKEVGVETTIIHGPSIETAAPGL
AGLQSYKFGRTATLPLPRKPSETPYGVIEENGKLGLHTLLLLDIEADEERYLTADRAIEH
LLNLEEELKRGVFTGETLCVVVARAGTTNPLVKAHRAQELKEMDFGPPPHAVIVPGKLHF
LEAEALERFAGAPEEVVKKNVEE
>A0A150IUM8|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MLYLIGLGLSEKEISLKAFELLTKIDNIYLDTYTNYFDFDLLWLENSLNKKVSPLSREDI
EKNPLFLETAKKEDVALLVSGDPLVATTHTDILLRANKKGIQTKVLHSSSIYSAIAETGL
HIYRFGKTASIPYPEENFFPRSFYDVTIENKERNLHTMLLLDVKKEKNLFMNPKEAIDIL
KRLDENNNIKDIVVISRISHENQRIIYGDMEELAKFEKEFYGPPPHTLVIPAELHFAEEE
YLLTLAEIYKNSKNK
>A0A150JDD2|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MLYLIGLGLSERDLSLRAFELLRKIVNIYVDTYTNYFDFDLLWLENELNKKIIPLSRNDM
EKNPTFLDIAKSKEVALLVSGDPLVATTHTDIILRANKMGVKTKIYHASSIYSAIAETGL
HIYRFGKTTSIPYPEENFFPKSFYDVIVQNKERNLHTMLLLDVKKEKNLFMNPKEAISIL
KEIDKNNNITDIIVISRISHENQKIIYGDIDKLIKFENEYYGPPPHTLVVPAKLHFAEEE
YLLSLAEIHKNSKNK
>A0A7R9N3X7|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon GB50|TrEMBL
MLTFIGLGLYDELDVSLRGLEAIRSADRVYAEFYTSRLTGTSVERLEELYSKKIHLLDRE
DVEGDPEWINDAIDHEVVFLTGGDAMVSTTHIDLRLRAERLGIKTKIIHGASIISAICGI
TGLQNYRFGRSTTIPHPYTTKSGKTMISETPYETVKQNRENDLHTLIFLDIDKEKGCMSI
GEGIKLLLRVEMERNEGIISEETLGVGVARAGSPTQVVRADYLRELEEVDFGAPLHTLCI
SASLHPIEAEALVAFAEAPGEILQKRE
>A0A427UID8|diphthine synthase|EC 2.1.1.98|Methanohalophilus sp|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNAGKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEINIAFLTGGDTMVSTTHVDIRLRAMEMGIETCLIHGASIVSAICGL
TGLQNYRFGKAATIPYPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMDKGYMTV
NQGIELLLQVDEKRGENLIKGSIAVGIANAGSEKPIVRADFAENLESCDFGSPLHIVVIP
ADLHFVEAESLIKLADAPESILEEGDIN
>A0A7C5VP70|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEIVFVGLGLHDETDISLKGLEEVKTADAVFIECYTSILPGFSLRRFEKLSGRTLRIVS
RKELEEENGEAILKAAEKGKAVLLVPGDPFVATTHMALRLEANRRGIKTRIIHGASIISA
VVGLCGLQNYKFGRSTTIPFPENYSETPYEIIAKNRKLGLHTLCFLDIDVETERYLTIRD
ALKMLLETEEKRRMDAVTKESLAVGIARAGSPDPTVKSDYVGELIFYDFGKPPHILVITG
KLHFMEAEALIAFAKAPTSVRRMIE
>A0A7J4CPT2|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopelagicus sp|TrEMBL
MLWFVGLGVSGGESIPVEVVKVIQNADMVYLESFTSPIYKHNEEKLKSLTNGNFKIAKRW
LVEDGQEILRTAKVSNVVLLSYGDPYIATTHIELRTRAKLEKIETKTIHSASAITSMVGE
AGLQFYKIGRIVTIMNEKKSLLTPYTTIFKNLLQGLHTILLLEYNEVENYFLNPKNAISD
LLEVEKEQKRNVVNENTFAIVASRIGFKTQMITAGKFSNLLKINFGEPPHSLIITGKLHF
TESDAMKVLTECLDKPLDNSNEIKSISIQMIEKYVPMVREALEEIKPFYNNVKEYQEILQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIEPKM
>A0A534LJR9|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLHDEKGITLRGLDEARSADVVFAELYTSGLAGATVASVEQLVGKKIRVLS
RNDVEDGRTILEAAAKQKVAFLVVGDPMAATTHVDLRLRAAAAKIPTRIVHGVSILTAAA
GALGLQVYKFGRTTTVPFPAAGFGPTSPLEAILENRRAGLHSLVLLDLREGGSFLTPQDA
LALLLRMAVKMGTSDFGPETLACVLSRVGSPEVRATGGPMGMLSDRDLGPPLHCIVIPGR
LHFLEKEALIAFAGAPHDL
>A0A510E3G0|diphthine synthase|EC 2.1.1.98|Sulfuracidifex tepidarius|TrEMBL
MGELYFIGMGLSRSLMTNKALDIIRKADVIIYDTYTSFSCDISPDYVRSLTSGKVIEANR
DLLENRSAEVISLAKEKAVVVATVGDPMIATTHVSMAIEARKAGVKVSVVPGVSVHCYLI
SKSMLSSYKFGKSVTIVYPSYGIMDTAPYSVIKSNRSLDIHTILYLDIREGKFMTPNEAV
SLLLQMEDMRKENVIKEDDVIVVGSRLGCEDEAVVSLSLSEAKKYDFGKPPHILIFPSNL
HYMEADALKWMTTK
>E6N8M7|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
MALTFVGGGLGRFEHLTIEALETVKNAEKIYVDTYTSFWAADFFDKLREAAGHVVAADRK
MLEDNVHKLVSEAVENEIVLLTPGDPFIATTHLAIRTLAHRKNVSVKVVHGVSAVSAAVS
SSGLHIYKFGKTATIPKTTDSNMLNEIFKTIETNLSNNLHTLLLLDTSDNGLTIPEAVKQ
LLDYSKQHGKNFINQNTLMVALARLGFPDNMTLAAPAEKLMIHNFPPPPHSIIIPSSLHF
TEEEILQTFHKGPLCIAENPLKSRVMNYVAKCRRILAELSDFHELTDYLGYVSRYVEDAE
RFVKDGNMVDALLAIGYAEGLLDALRLRGEVTFTW
>A0A7J4KMJ0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALYFIGIGLNDEKDITVKGLGIVKRCKYVYLESYTSILQVPVSALEEFYGKKIIIANRA
MVEIKSNEIINDAKQDDVAFLVIGDIFGATTHYDLLLRAKKENIKCEFVHNASVMNAIGV
VGLELYKYGKTTSIPFPEKGFKPETYYDVLKMNKENGLHTLILLDLRPREQRFVTANLGI
QYLLEIAATRNDNIFDENTMVVGCARIGGDFHIKYGKAKDLLNHDFGKPLHCIIVPGKLH
FVEEEALKQWG
>A0A2D7BPF9|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLSFVGLGISGFESIPIEGLETISNADIVYLEQFTSPISESDLKKIQDSIKGEFKLAKRW
LVEDGNEILEMSKEKNVVLLAYGDPYIATTHIELRARAIENKIKTHSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNLIEGNHTVLLLEYNQDKKFFLDPKDALKG
LLETEQGQARKVITESNYVIIASRIGFKDQAIVSGKISSLKETDFGQPPHTIIIPGRLHF
TESDALKLFGKCVDEPFDNSEKTEKISKQMIKKYVPMVREALEEIEPLYKNQKEFEVILD
NAERYIKDAEIFLGEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A3N0A038|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp. D6|TrEMBL
GDPYIATTHIELRSRAITQGITTSTIHAPSALTAIVGECGLHFYKVGRVATIMGGESFST
PYYTTYKNMVQGGHTILLLEYDQEREFFLDPKDALTGLLEAEKGQTRNVIGQSTYCIIAS
RIGSADQKITAGMISSIVKTDFGGPPHTVIIPGSLHFTESDALDASCVCIDSPTGNTVEK
ISAQMIAKYVPMVREALNKARTTHAGRHDEILENAELYIRDAEKFLADGQDEVAVLSIGY
ADGLIDALRMADGLEPKM
>A0A2H6JXG5|diphthine synthase|EC 2.1.1.98|archaeon BMS3Bbin15|TrEMBL
MLVLIGLGLYSEKDITLMGLEEARSSDYIFAEFYTSVMPGLNLDRLEKIIGRKVRLLSRS
DIEEEGEKVILERAKKSKVSLLVAGDALISTTHVHLLLDARESEIEVRVVNNASIYSAAP
SLAGLQNYKFGRSASIARPEERFFSETPYTTVKANMKMGLHTMLFLDIKVEKSGTYLMHA
KEALEILLKLEDRKKEGVINTETIAVVVSRAGAPEFKLKAGSIRKLLEEDLGRPPHTLII
PAEFHFMEEEFLRAFASLSEE
>I7KY65|diphthine synthase|EC 2.1.1.98|Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2)|TrEMBL
MLMFVGLGLYDLGDISLKGLECVRNADTVYLEAYTSRLMGTDVAEMEAFFEKEIRVLSRE
DVEQNPRDIIERAARGRVAFLTGGDPMVSTTHADLRMRAAAAGVATSIIHASSISSAVCG
LSGLQNYRFGKSCSVPFPAKGWFPTAPVETIAANLDLNLHTLVFLDIQMDRYMRIPEAIA
IIEEMAAKRGIEPPALYVGIARAGSESPVVAAGSGAKLKETQFGPPLHVLVVPADLHPME
REYLEIFAGL
>A0A533WXN7|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MMGRLTFVGLGLGARGISLLKELENETGRVMTVVDREFVEDGREILKEARGSRVVLAVPG
DPMIATTHNELRVRAIGQKTETAVIHAATIPSSAASASGLHYYKFGQMMTITRETLDSMQ
QAYHTLQTNLLQGLHTLLLLEFDVEGGEGAAPPAVIGGLLRAEKNFGREVLTEETFALVL
SRLGRQDSELRAGYLKDLRNSEYGEKPHCIVIPGGLHFTEVEAVAAIFGLGEGEVRDNSR
NIKGTAEVLIPRYAAKTRRALNSARERLGRDYDTLLENVELYTKDAEGFLARGEHELAML
SMGYAEGLLDSAGFTGRAKIDW
>A0A7C0TXL9|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MRKGKIYFVGIGLTPKHVTLQALEVIKRVDEVYMDSYTSLLVDDGNELAKVLGREVKYLR
RTDIEDKSLRDAIKKVDEGLDVAVLVVGDPHIATTHVALINELRMRGYDVEVIPGISIFC
AVMTYTGLSSYRFGKPATIVFPKGGVEYGYPYYVIKDNKERGLHTFLLLELDVEKGVFMK
INDAIDILLRFEERYREGVLSLDEEAVGIARLGGKDQLICVDRLSRLREIDFGGPPHSLI
ILAPKLHFVEEESLKVLKSEFRERCSKAP
>A0A6V8DAE9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPLIGTTGQDGISMTVELPPTGLLLVGLGPGGLRSMTVAALEAAEKADHRWYEAYTALWP
EPDLIELEARTGPIERVMRPDVEDPGRLFELARTSLVAMLVVGDPLQATTHVDLQLRARE
AGVPCHVLHGLSITGTVTGAAGLSNYRFGRQTTLTYPHGSWIATSPLETIAMNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHLMTERLAERSEEAVSELKSRAMQNQDIGSWT
VVLCADVGTADEFFVTTTVDGLPAEPGGRLNCLLVPAEVDGVEADAIGRWRRP
>A0A1Q7QUI9|diphthine synthase|EC 2.1.1.98|archaeon 13_1_40CM_2_52_13|TrEMBL
MSLTFIGLGLNDEKGMTLEGLEEARQADSAYGEFYTNIMPNLDLKRLEKNIGKKVEVLNR
TQLEDEGGEKLLKAASKQRVAFLVPGDPLIATTHISLRLSLAKMGIPSRVVHAPSIVSAV
CGATGLQSYKFGKSITVPRDQPLPRSLLDTISDNSHRGLHTLILLDVQAGKTSQMTIRDA
ITKMTTADPHLETRVAVGLARLGSRDEKVKASKMKILTGEDFGNGPQSIIVVGRVHFMEA
EALEVLCGAGEEDLRELS
>A0A3A5VV77|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MAFALSKRHGGLSMAAEENEDDSFPSTGLLLIGMGMGSLEGMTRAAIEAARNADHRRYEA
YTALWPEDELKRLEAEVGSIERVMRPEVEHPEALFSLAKKSVVALFVVGDPLQATTHVDL
QLRAESAGIDCHVYHGISITTVATGAVGLSNYRFGRQVTLTYPYGDWIATSPLELVAVNW
SRNLHTLVLLDLDPTGQGTGEQRPMKPADAVNSMRLMWEKVELRKDEPISEEFMLLAQEQ
AIVNGYMMQAFDDLPVVLCSDMGTVDQHIVTTTLGALADEPGGRLNCLIFPAGTSEVEEK
ALLRWKRGGE
>M0B2Z2|diphthine synthase|EC 2.1.1.98|Natrialba aegyptia DSM 13077|TrEMBL
MLTFIGLGLYDERSITVEGRGALRDADRVYAEFYTSKLLGTTVPSLEAAHDIDIEVRDRA
GVEQHPEDILETAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGPATTLPFPYAHGADGLPASVTETIDENRADGLHTVVYLDIKVGNSSPSSQ
NPVGSDDKANRDDEDEEFMTADVGADLLAAAYPELVGVVIARAGSPDPLVEAGTMSELAD
REFGEPLHLLVIPGECHLLEADALVELAGAERNALDVV
>D3RYR9|diphthine synthase|EC 2.1.1.98|Ferroglobus placidus (strain DSM 10642 / AEDII12DO)|TrEMBL
MLTLIGLGLWDEKDITLKGLEEVKRADKVYAEFYTSKLMGTSIEAMEKLYGRKVVVLERK
DLEDESWKIVEEAKSKNVVILVAGDPGVATTHSSLLLEAKRKGVETRVIHNASVISAICS
VTGLHSYKFGKSATVSYPYRGIVSKTPLNVIKENLSINAHTLLLLDLNPKPMTIGEAVKI
MEKVDDGTLNHFAVGVARIGGDCYIKCDHFYSLPNHDFGKPLHTIVFLSKKLHFTEYEFL
REFADAPKELEEFVE
>A0A831UTZ3|diphthine synthase|EC 2.1.1.98|Thermoproteus sp|TrEMBL
MARLYLVGLGLSPSFLTEEARRALRDADCVFADVYTSYFDYGRLGIEARPLGRADLEDRG
GAAIEECLRAGRNAALLVPGDPLAATAHAALVASMRRRGHEVVVVPGVSAVCAAMSAACL
SIYKLGGVATVTYPRLGVYSARPYELAESNLARGLHTLLLLDVRDDGGFMTPAEAAEILM
ELERREGRGVFGGGRLVAVVYRLGWPGGGVAVGPLADLAGSRLPPPAVIIVPSKMGPVEE
ECLSTLPKIGAPP
>A0A0P9DV18|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon BA2|TrEMBL
MGELVFVGLGLYNEKDISLRGLEEIRKADAVFAEFYTSLMPGLSFQKLERLARKKITVVS
RKILEEEDGKPISDEAKKGKVAFLVPGDPLIATTHVDLRIRAERQGIKTRVIHGSSIVSA
VMGLSGLQNYKYGRSVTIPFPKEGFTYETPYRVIMENRTMGLHTLCYLDIKAEEQRYMTI
KEGLQSLLDVEKQKRRHVITPSTLVLGVARAGSDDPTVKAGYVGDITNHDFGPPPHILVF
PAKLHFMEAEALITLAGAPEQIREIVK
>A0A7J4I7D1|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MKNCQDVYCEFYTNKWLGDMDKLEEIIGKKVKLLKRVDVESELLTDEAKTKDVALLVPGD
PLAATTHIQLMIDAQSKNVETAVIHSSSIYTAVAETGLQLYKFGRTTTLAFIEKSFKPSS
PYEVIIENRKAGLHTLVLLDVKEDNRYMTISDGIDVLTQLGMDKEIKIVACCQLGGLEQK
IRYGTMNELAKDESLLGTPAVIIIPGHLHFKEEEALRIYD
>A0A497TH15|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGLWDENDISIEGIETCRKSEEVYAEFYTAKWGGDIKALEK
>A0A3N5V4D1|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLYLVGAGIYDTFEMCNSTRILKSCDRIYLESFTSPISDKFIDILKTTVGPEKKIEFVKR
WFVEDGRQILDESKTLDVGLISYGDPTIATTFTELRIRAIKNKIDVKVVHAASGITSLVG
ECGLQIYKIGKMVTMMEERQSAISVYSTVFSNLNVNCHTIILTEYRQGDDGSVFFLKPNN
MMSRLLDVEKDIMYGFVSEDSFLIVLSRIGTDEQKIFSGKIKSLLELDYGNGPHAIIFPS
KFHFTEEDAVLNLTENIDAPTDNTVMIKSVSDHMLNKYEPMIRNEIKQIRESIASRNSNK
AQIELLENAEFYLDDAVQFFRQGKKELAILSIGYADGLVDSIKQMLEVE
>A0A371MMS0|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-12N|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPVPVVASDRLSALAERDFGEPLHML
IIPGEVHHVEADALSALGGAPEELFDDEN
>A0A838AKQ2|diphthine synthase|EC 2.1.1.98|Nitrosarchaeum sp|TrEMBL
MLWFVGLGISGSKSIPVEAIEILSKADIVYLEQFTSPIEKSDMLKIKKITNAEFKEGKRW
LVEDGKEILKYAKTKKVVLLSYGDPYIATTHIELRTRAIKEKIKTFSIHASSSLTSMIGE
CGLHFYKLGRTATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKNYFMDPKEALEG
LLETEKGEKRNVINLDTHVIVASRIGFKDQSIISGKISSLKKIDFGKPPHTVIITGRLHF
TESDALKILGKCHDEPHDNSEKTEKIALQMMKKYVPMVREALEEIIPLYKDQKEFKVILD
NAELYIQDAEKFLEDGQDEVAVLSIGYADGLVDALRLAKGLEPKM
>A0A518SCZ0|diphthine synthase|EC 2.1.1.98|Salarchaeum sp. JOR-1|TrEMBL
MLTFVGLGLYDEESITVEGREAVREADRAFAEFYTSHLVGATVDDLQSYHDTHIEVRDRA
GVEQDPGPILDAAESEDAVFLTAGDTMISTTHVDLRLRAHDRGIDTRVIHAPTAESAASS
LTGLQNYRFGKATTLPFEWVHGADGVPGSVIDTIEDNRERGLHTLCYLDIKVDNPYREGD
DYMTASHAAGLLAEHWNPDALGVVVARAGAPDALVEADTLGALAQRDFGSPLHLLVIPGA
LHHVEADALTGLAGAPDDVVEERTV
>A0A0B5HP12|diphthine synthase|EC 2.1.1.98|Archaeon GW2011_AR10|TrEMBL
MLCLVGIGLTPKHLTLEAIDTLKECKRVYIESYTSSYAEGTISELELRLNKKISALKRKE
VEEGIRELLIEAKKENIALVVFGNPLTATTHVQIILDAKKAGVKTKVVAGISVTNYLAKT
GLDEYRFGRTCTVVAPKENFSPESFYGVIEKNLNAGLHTLCLLEITEEGKLMSIREAIEV
LEGIQKKKKNKAIDRALLVALSAAGSSKEEIVAGKAEKLKKHKFNGMPQSLIVCGKLNEK
EREAIGELNE
>A0A6G2HGP9|diphthine synthase|EC 2.1.1.98|Halorubrum sp. JWXQ-INN 858|TrEMBL
MLTFIGLGLYDERSITVEGREALRTSDRVFAEFYTSRLVGADVVDLEAYHGVDIEVRPRE
GVEQDPEAILEAAATGDAAFLTAGDTMISTTHTDLRLRAERRGIETRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADYAADLLADGWDDVLAVAVARAGSPDAVVAADRLSALATREFGDPLHLLVI
PGDLHHVEAEALSGLAGAPDDLL
>A0A842NZ39|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPSEALDVLSKADIVYLEQFTSPIAKSDLTKIKNATKGEFRLAKRW
LVEDGSEILKNAKKKKVVLLAYGDPYIATTHIELRTRAIEDKIKTYSIHAASSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALNG
LLETEKGQIRNVISPSTYVIIASRIGFKDQSIISGKISSLKKTDFGKPPHTVIIPGRLHF
TESDALKIFGQCVDEPFDNTEKTEKISIQMMKKYVPMVREALEEVEPLYKDQKEFQGILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLEPKM
>A0A843BL56|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPISKSDLTKIKNATKGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRITTIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LLETEKGQRRKVISSSTFAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNSEKTRKISIQMIEKYVPMVREALEEVEPYYKDQKEFQVILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A832FIN7|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGIGLYGLRDLPLGVIEIARGADRIYLEQYTSLAPGFSLEALEELFGKHVEEVARQ
DLEEQSGRELLEQARKSTVLLLTFGHPLIATTHTSLVVEARKAGIPVKILPAPSVFDGVI
CSTGLHVYRFGRPVTLVFPERGRKIYPYTTYAVIRDNLRRGLHTLLLLEIRRQEGVYMDV
ATAAALLLELEEVFHEHVISEDTLAIGVARATAPDEVVKVGELRELAGEDFGPPPHSVVI
PGVLHDSEIEFLSSVHGAPVEVMINWNKHVKKRLESTFEP
>A0A6G2G2Q5|diphthine synthase|EC 2.1.1.98|Halogeometricum sp. CBA1124|TrEMBL
MLTFVGLGLYDERSITVEGRDALADADRAFAEFYTSHLVGATVADLEAYHDVEIEVRDRA
GVEQHPEEILDAAADDHVVFLTAGDTMISTTHVDLRLRAVERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVTDSIEANRERGLHTLVYLDIKADREEYMSA
DYAAEMLAEGWRDVLGVAVARAGSENPVVAADRLSALADREFGDPLHMLVIPGDVHHVEA
DALRTLGGAPDDVVAENEV
>L0HCV2|diphthine synthase|EC 2.1.1.98|Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)|TrEMBL
MLTFIGLGLFDKTDVSEKGLSRIRNADRVYLECYTSRLMGATREGLEQYYRRPVTPLYRS
DVEQDPDAMLEEATTKDVVFLCAGDPMVSTTHADLRIRAASRGIPTAIIHAASIASAVCG
LSGLQNYRFGKSCSLPFPQKNWFPTTPLDVILANLSQRLHTLVYLDIQDDRYMTVPEAVA
LLEEMAAARKEKIPLYVGIARAGSDEPVVRAGPGELVRACDFGPPLHILIVPAELHDMER
EYLEMFAGL
>A0A7J9PJE2|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTSMEKIENTLQKPITVLDRE
KVEYETNKLIEEAVDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSVVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRNENVISGETYAAVVARAGSIKPGLYYGKIKDLINYDFGTPLHCVIIPGKL
HFMEEDALKYLFENI
>A0A6N0NRJ5|diphthine synthase|EC 2.1.1.98|Metallosphaera tengchongensis|TrEMBL
MANIYFVGLGPSKMFLTKASIEAMRNADLIMLDKYTSITCDLTAEALTEITGRPVILADR
NLLENRQREIIKHLDEGRNVAVVTVGDPMIATTHVSLAIEARKKGHDLKVIPGISVHCYV
ISKSMLSSYKFGRSVTVTFPVLGKLDPTPYRVIKANREQGLHTILYLDLKEDAVMTAEVA
LNYLLQLEKEIGEGVLTHEDWIVVGERLGCPDERVRAMKIKAAKMEKFGEPPHIIIVPSR
NLYEMEVEALKCLV
>F4HII4|diphthine synthase|EC 2.1.1.98|Pyrococcus sp. (strain NA2)|TrEMBL
MITPISVRQMALYFIGLGLYDEKDLTLKGLEIARRCEHVFAEFYTSLMAGTNLEKIERLI
GKKIRILNREDVELNFERIVLPLARDSDVAFLTAGDPLVATTHAELRIRAKRFGVKSYVI
HAPSIYSAVAITGLHIYKFGRSATVAYPEDSWFPTSYYDVIKENKERGLHTLLFLDIKAE
EKRYMKANEAMDLLLKIEEMRKEGVFTKETFVVVLARAGSLEPTIRAGYVKDLIREDFGS
PPHVLIVPGRLHVVEAEYLVEIAGAPQEILESFKV
>A0A2P4NWC4|diphthine synthase|EC 2.1.1.98|Haloferax marisrubri|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGAILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGDPLHML
IIPGEVHHVEADALSALGGAPEELFDEH
>A0A2H9LQT0|diphthine synthase|EC 2.1.1.98|archaeon CG07_land_8_20_14_0_80_38_8|TrEMBL
MFYLIGAGINDYADMPLKGLEYCKKCSFVFLEKYTSIFSDESVKKLEELIGKKIIIVGRE
DLENDFEILILEKAVKNDAALIVAGDPLAATTHIEFLRSCKERGVDYKVVHASSIYSGVC
EIGLHVYKFGKSCSIPFPEPNFNPTSFFDVITENHNIGAHTLVFLDIKQDLKKYMTINEG
LKILLKISKDKGGFFDEDCEVIGIARLGSDNQVIKCGSVKELLNFDFSANPHVLIIPCMN
DIEREYVANLYL
>A0A0E3RH07|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei S-6|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A327GWU4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED132|TrEMBL
MTAGNSTELPKSGLLLIGMGPGQIGSMTIEARNAAKSADFRRYEAYTALWPADELTKLEE
DIGDIEMVMRPEVESPTELLDLAKNHLVALLIVGDPLQATTHVDIQLQALEAGINCMVFH
GISITTLVTGAVGLSNYRFGRQTTITYPYGGWVATSPLEVIAVNLFQNQHTLALLDLDPT
GAGTGKQVPMQPKDAYDSLGLMKEKLSSTISDMSEESTFDSMKKLAFKEFVANGLDSIKV
VLCADMGTKEEKITYTTVGDLKNTDGGRLNSLIFPAITSEVEEKALLRWQ
>L5NX18|diphthine synthase|EC 2.1.1.98|Haloferax sp. BAB-2207|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A1Q7MJG3|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_40CM_3_52_10|TrEMBL
MSVAFIGLGLNDERGLTIEGLEEARRAGSVFAEFYTNIMPGLDIKKLELLLGKRVVVLGR
TQLEDEGGKRIVEAAKRERVAFLVPGDPMIATTHISVRLELAKKGIPSKIIHGPSVTSAV
CGATGLQSYKFGKSVTLPQEPGVPDSLLDTVRDNKTRGLHTLILLDVRPEMAQQLTIGEA
AAKLVTADRTLESRMGIGVARLGSEDQFVLSAKLGKLENQDFGRAPHCLVIPGRLHFMEA
EALKVFCGAEDEDLEALK
>A0A7J3VTM7|diphthine synthase|EC 2.1.1.98|Nitrososphaerales archaeon|TrEMBL
MLILVGMGIHGYKGLSVEAIDAIKGASRVYIEAYTSPVMSKDIDTLRALRDDVVEVHRWF
VEDGRRILDEARVGDVVLLSYGDPLIATTHIELLVRARSAGIACKVIHSSSIVTAALGEC
GLHVYKLGKVASVVVSNPIANTSTYYAIYSNLMQMNHTLLLLEYDKEHGYFLAVDSALML
LLDCEAREHMHVIDEDTFAVVASRVGMEDMSIVGGRIGSLLKYSKEHGFGEPPHTIIVTG
SLHFTEVEALKVSATLLDEPIDNSKRVMRKAEIMLSNYIARAYGALSKAREYIMHAKGDD
VNKANDMDMDDTIGRLKDMIDNAEYYLSDAERFAREHRYENAILALGYAEGLIDALRYLR
DIDPWESKKGRAPQ
>A0A256I2L0|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Ea8|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVDELEAYHDVEIEVRPRE
GVERDPEAILSAAAEGDVAFCTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWRDELAVVVARAGSPEPVVAADRLSALSEREFGDPLHLLVI
PGDLHHVEADALAGLAGAPSELVEE
>A0A2R6IRU0|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_6_71_20|TrEMBL
MLSFVGLGLWDERSVTVEGREALQSADRVFAEFYTSRLAGTTVEELADHHGVDIEVRDRA
GVEREPGPVLDAAADGDVVFCTAGDTMISTTHVDLRVRAAERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFEYAHGADGTPASVLDGIAANRERGLHTLVYLDIKVAGSSPAGP
AEGEPDEYMAADHAAAALARDWEEDAVGVAVARAGSPEPVVAADALGALADREFGDPLHM
LVIPGELHHLEAEALAEVAGCPRDVLPGEE
>A0A6N0NPS0|diphthine synthase|EC 2.1.1.98|Nanohaloarchaea archaeon|TrEMBL
MLYLIGLGLDDGEITQKGIEALKNVDKAYAEFYTNTETVDLEALEEQTGTDIEKLSREQV
EQEDMITESAHEEDTAFLVSGNALTATTHYEIKHRAEKEGLDVEVIHAPSIFTSISETGL
NVYNFGRTVTLPQDFAPESIVEHIEKNDSIGLHTLVLLDINYDAADAAEKLIDLDEDLED
REAMVLERANNEDQNISLASLGELSEHDFGRPPHCIILVGETSHMEEEFIEEYSLE
>A0A151EYF2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon SG8-52-3|TrEMBL
MSSGNLIFIGLGLYDNKDISLKGLEEIKNCDKVFAEFYTAKLTGTTVEKIEKIIGKKIEV
LTREETEKGDKILNIAKEKTVAFLTSGDTMTATTHVDIRLRAAKMKLKTRIIHGSSIVTA
VPGLLGLQNYKFGRATTLAYPEKNYFPTSPYNIIKGNKESGLHTLVLLDIQSDKKRYMTA
NEGMNLLLKMEEKHKEDIINKDSIICVVARAGSFEPIVLAGTIRDIINRDYGPPLHTIVI
PGKLHFMEIEALETLAQLPAQQGRKLQKL
>A0A832TCT6|diphthine synthase|EC 2.1.1.98|Thermococcaceae archaeon|TrEMBL
MSIYFIGLGLYDEKDITLKGLEIAKNCDLVFAEFYTSLLAGTTIEKIEQQIGKPIKLLSR
EDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSIYSAI
SITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYMTANE
AINILLQVEEMKKEEIFTEDTLVVILARAGSLTPTLKAGYVREMIKEDFGKQPHILIVPG
KLHIVEAEYLVEFANAPKEILKEV
>A0A7C5Y053|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLTISGLGLYDVGDIPRKTIAAAGKADKIYYETHTNLYHSTINEIREILGEKVEEVGRRF
LEEDSKKLMLEAKTQDILVLVPGDPLAATTHIELILEAKNAGVQTQVIHASSIFTAIAKT
GLQLYKFGKATTLPFKTEAKLPTSPYHAVKQNRDSGLHTLILLDVKSDEQRYMSANQGLE
VLLELENEIGLGLFRNDTLMAACARLGAPDEIIKFGEIQKLLKTDFASPPHVLIMPGDLH
FKEEEALNQYA
>A0A2A2HHY4|diphthine synthase|EC 2.1.1.98|Methanocorpusculum parvum|TrEMBL
MLTFIGLGLFDESDVSVRGMDAIRYADTVFLEVYTSVLTGASIERLEACYGKKITPLYRE
DVEIHADKILDAAEFGNAVFLTAGDSMIATTHSDLRIRAADRNIQTKIIHGASITTAVCG
LSGLQNYRFGKSVSVPFPYGKWFPMTPIEVISANQKENLHTLVFLDIQKDKERYMKISEA
VDLLEEQARRVDAKIPLYVGIARAGSPEPAVHAGSAEEMRSFDFGSPLHILIVPAKLHDI
EREYLERFAGLC
>A0A1V4Z6P9|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon PtaU1.Bin030|TrEMBL
MRALTTLRNCDEIFAEYYTSKLTDASHRDVEAFIGKKVTVLKRGDVEEKDVIIKAARDRR
VAFITAGDPMSATTHLDLRLRAVEEGISTDLINGVSIFTACSAALGLQPYKFGRTVTIPL
PEPGFLPSSPYENILENRSRGLHTLILLDIKAEENRYMTAPMAMQWLLDAEERIGSGLVK
GDSLFCAAARVGSPKQALFAGYPDEILTVDLGPPLHCMVMPGRLHFMEARGLVAFANAPR
EILEEGVSGSEAKQ
>A0A7C4MDF5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLALVGLGVHGIRSMTLEGFEVLKESDQIYLDGYTTCLPEKFVDELKDLVKKDVNVIFER
KKIEEETDRILEEARIKNVSFAVLGDPLFATTHLTLVLECKKKNIPCKVIHNTSITSILM
NSFGLHSYKFGKIATIVRRSGTPATTVYFTLYENLIRKLHTIFLLEYDVEADEGVTPKDA
FQILKEGEEIFKLGAFSNETFAIVACRMFREDEKIYVGKVQELLEIDFGRPPYSLIIPSE
LHFVEKEALSALFNLEKYVEINNSKMIKRRVEHLINRYVRNTKAALVEARKRLPQREFED
LFENVECYLDDAIRFFNLGEENLAMLSVGYAEGLLDALRFQKILDLKW
>A0A497EYA7|diphthine synthase|EC 2.1.1.98|Candidatus Verstraetearchaeota archaeon|TrEMBL
LLDIDVESGRFMTINEALEILLQIESRRREKLIREDTLVVGLARLGSVDAIVKADALANI
VKLNFGGPPHSIVIPGKLHFVEAEALVTLAEAPRTILNYK
>A0A0X8V1P3|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon (strain ISO4-H5)|TrEMBL
MTSELIFVGLGLSGVDGMTVKAFNALKECDKIYAEFYTSHLIGTEIEDLKKALGKKIEVL
YRAQVEEDKELPAVIRDAKTMRVAFVTAGDTMLATTHVDLRIQAMYEGIPVRMFTGVSIF
TAAPAVFGLQPYKFGRTVTLPFLEQGYQPKSPYDHIMANKKLGLHTLILLDIRAEELRYM
TAKDAIEWLLAGEEKWQEGLITDKTLLCVVSHAGADDMKLVAGYPKDLLSMDLGSPLQSV
ILPGNLHFMEAEALVDFAGAPKEIIEDD
>A0A7J2YVL0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTELVFVGLGLNDEKGITVKGLEETKSADAVFMETYTSRMPDFSMQRFEETCGKKVQLIT
RRDLEEDNGKIILEAAKNGKTVFLVPGDPFIATTHVTLRIDAEKHGIPTRIVHGISIISA
IVSLSGLHNYKFGKTVTIPFPENFSETPYNVIAQNRKLGLHTLCLLDLKQAENKYLSIKE
AVQLLYQVEVKKQQKIITADTVAIGIARAGSDQPTLKADFIKNLAGFDFGEPPFSLIIPG
DLHFMEIDALIAFAGAPKEFRSLVK
>A0A7C5U0H2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLVFVGLGLNGLEDITVSGMKWIRYAEKVYLDMYTSIIPNFSVENLEKNIVGRKVIKASR
KDLEENYEEILNEAKNKIIVLLVPGDPFVATTHMQLRLAAIDRGIETKVIHAPSIQSAIY
GETGLFSYKFGRCVTVTFPYGESICETPYDVIKENMKQGLHTLLLLDMDAENMRFMRISE
AIDILKRIEEKRRENVIKKDTLCVGCARIGSDTQVVRADYIDELSKVDFGAPPYSLVIVG
RLHFYRSRSISKVG
>A0A7C7VLU6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGTLTLIGLGLYDELDISLKGVKVAKKADTVYIELYTSLMRGLSLDRLQKILGRTINVVN
RRVLEEENGEILLREAERGSVVLFVPGDPLIATTHVDLRIRAEKRGIKTQVIHAASIISA
AIGLSGLQNYKFGRSVTIPFPEPSFIYETPYMVIYENKKRNLHTLCFLDIKSEEDRFMTV
REGLDALLNVEEKKGLGAVTSSNIAVGIARAGSEKPVVKSDFIEKLKNFNFGSPPHTIIF
PAEKLHFIEAEALITLAGAPEAVRRMVK
>A0A497F6Z2|diphthine synthase|EC 2.1.1.98|Candidatus Verstraetearchaeota archaeon|TrEMBL
MLIFVGLGLYKLNDLTLSGLSWMKAADILYLDTYTSIIPGFSMKLLRELIGKDIVPLRRK
QIEEEGERILMEAKDKIVVLLVPGDPFVATTHMRLRLDAVEKNIETKVVHAPSIISAISG
ETGLFNYKFGRTVTIPFPYENYLSETPYDVVKENLERNLHTLLLLDADVERDRYMSINEA
LEILIKIEGKRREAIITMDRLVVGVARIGADDSIVIARPIKELLKRDFGPPPQSIIIPGR
LHFIEAEALVKLAGAPRRILK
>A0A497LKR4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGKLVFVGLGLRGLGGIPLEGLEKARGADRVFLELYTSPMADFSPEKLEKLLGKPVTLLR
RVDLEDEGGRKVLEAAGGGCAVFMVPGDPLIATTHVDLKLRALKAGVKVEVVHAASIYSA
APSISGLQIYKFGKTVTIPFPSSGYTPETPYEVLRENLSRGLHTLILLDYDAEKGRWMTV
KEGLQYLLSVEEKRGEGAARPERLALGLAGVGGPDVEIRGGAMGRLAKADFKLKPQTIIV
PGSLHFVEAEALKVLAGVSAEELNLESPG
>M0HP53|diphthine synthase|EC 2.1.1.98|Haloferax elongans ATCC BAA-1513|TrEMBL
MLTFIGLGLYDERSITVEGAEALEAADRAFAEFYTSHLVGASVSDLEAYHDIDIEVRDRA
GVEQDPDEILDAAEAEHIAFLTAGDTMISTTHVDLRLRAEERGIETKLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPFVHGGDPVPQSVVDSLEANRERGLHTLVYLDIKVEWEGRRGV
EIDGDEYMTADYAAELFAEHWDPDALGVAVCRAGSPNPVVAADRLEALAERDFGDPLHML
IIPGEVHHVEADALMALGGAPENLFGDF
>A0A564Q6W8|diphthine synthase|EC 2.1.1.98|Candidatus Methanolliviera sp. GoM_asphalt|TrEMBL
MLTFVGLGLYDERDISLKGLYAVKNSDYVFAEFYTSRLMGTDVRGLEKFYGKDVYELKRE
DVEIHAEKIIEKAKRDDVCLLCGGDPMMATTHVDLRMRAHDAGVETKIIHGSSIQTAAIG
ICGLQNYKFGRSSTIARPYKDKIPETPYDVLVNNLKNNLHTLFFLDLSEAPMAIREGLEI
LLNIQERRKEEILDIGIGIARAGSEDVRVKADFIEELMKYNFGPPLHLLIIPSKLHFMEA
EALVKFADAPKEIMER
>A0A2H9NS29|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon CG_4_10_14_3_um_filter_37_21|TrEMBL
MLNLMGLGLSDEKGLTLEGLETLKKSDKIYIELYTSKWFGSIENLEKMTGKKIMQLKRPD
LEENLEKILKEAKNQTISILIFGDPLVATTHTALLIEAKKLGIKTRVIHNASIYSAAGET
GLHLYKFGATVTIPFLEKMNNQFPESLSKIIRDNKGRDLHTLCLLDLISEKEKYMTPSEG
MEVLLKSDDITQEDEIVIFGRAGSEEPLIAYGKIKNLIDKDFGNPPFVLIILGKLHFTEK
EYLEYHRAD
>A0A124FHV8|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 40_45|TrEMBL
MVIKMSIYFIGLGLYDEKDITLKGLEIAKNCDLVFAEFYTSLLAGTTIEKIEQQIGKPIK
LLSREDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSI
YSAISITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYM
TANEAINILLQVEEMKKEEIFTEDTLVVILARAGSLTPTLKAGYVREMIKEDFGKQPHIL
IVPGKLHIVEAEYLVEFANAPKEILKEV
>A0A3A6PT91|diphthine synthase|EC 2.1.1.98|Halonotius aquaticus|TrEMBL
MLTFIGLGLYDEGSITREGEAALQAADRVFAEFYTSRLLGADVDDLEAHHGIEIEVRDRA
GVEQDPEPILQAAENGDAVFLTAGDTMISTTHADLRVRAADRGIDTRVIHGVTAETAASG
LTGLQNYRFGKAVTLPFPGLHGSGDVPPSVIEAIDANRERGLHTLVYLDIKVDSHRELSA
LDTDDPYMTADHAAGLLANDWEDELAVVVARAGSPEPVVAADRLSALAKQSFGDPLHLLV
IPGELHHVEVDALESLAGAPESILPTESDR
>A0A7J3SKV5|diphthine synthase|EC 2.1.1.98|Fervidicoccus fontis|TrEMBL
MLKCDGEIFFVGLGLMEKHITVEAAEALRAADKIYVEGYTSFYYPDVYTSLKNLGIPEEK
IKNVSRRDLEDNSGEELLRHASMGNKVALATVGDPFIATTHLALRLRFERYGCRVRYMPS
VNIFSYSISKTGLFSYKFGESATVVYPRDGILSTYPYLVLEENLKRGLHTFFFLDIDEKF
GPLNAAEAVKLLLRIESEERRGAFTEGTDVIIVERASWPDERIILTSAGKAKEKRLNPPH
SLIVPGKLHFMEKESIEVFRT
>A0A842PWP9|diphthine synthase|EC 2.1.1.98|Nitrososphaera sp|TrEMBL
MLWFVGTGINGYRGLSIAALEVLRKCDIVYIERFTSALSEVDIQGLNSLLQMHTKPVQRW
FVEDGRDLLEEARTKDVALVTYGDPLIATTHSELHSRAAKNSIKTAILHSASGITSIIGE
SGLHVYKFGRMTTMMSELHSAVTVYNTIFQ
>A0A534LB23|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLDDEKGITLRGLDEARSADVVFAELYTSALPGASLEAVEKLIDRKIRRLT
RQEVEDGQVLLAAAAKGLVAFLVPGDPMTATTHVDLRLRAAASKIRTRIVHGVSILTAAA
GALGLQAYKFGRTTTVPFPSAGFAPTSPLESILANRTAGLHTLVLMDLREDGTFLAPRDA
IASLLRMASAIGTTEFGPHTLACVLSRVGSPDVRALAGLIAELADRDLGPPPHCLVIPGT
LHFLEREALVAFAGAPHGL
>A0A7C4F734|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLTFVGLGLGDEYDVSLRGLEAIRKADIVLAEFYTSVLCRMSVERMEKLYGKKIKVLSRK
DVEEGGKEIIEMARDKDVVFLCAGDSMVATTHSALRNLARKEGVPTKIVHGASIYTAVSG
ILGLHIYKFGKCVSLPRPEKNFFPCSPYQGICENLSQGLHTLILLDIKADEGYFMSASEG
LQILLEMERREKKGIITPQTRFCAVARAGSEDCIAVYGELEKLLSIEFGAPPHALVLPGN
LHFTEEESLECIRCR
>A0A327H520|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MDSNGLFLIGMGPGGVSNMTEGAISAAKAADHRRYEAYTALWSEEDLSELEDRIGPIEKI
MRPEVEKPAQLLELASTSSVALLVVGDPLQATTHVDLQLQAAEAGVSCSVIHGISITSIV
SGAVGLSNYKFGRQTTLTYSYEGGWIATSPLEVIGLNHAQGLHTLAFLDLDPTGAGTGDQ
RPMQPKDAVESLLSMAEKLLLYSEEMPTDTVYDRMKFDSVVKICNEISSLMVILCSDMGT
KKQAIRYLSVSELSGATEGGLHCLVIPSELSEVEVTALQRWTKK
>A0A147JZP4|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon DG-33|TrEMBL
MLVFIGLGLNGEGISLRGLREAREADVVYAELYTSKLPKLRLDEFGQTIGKPIKVVDRET
VEQRPDEILHAAKVSKVAFLVPGDPMVATTHVDLRLRAAKAGIETKVVHAASIASAAAGL
AGLQSYKFGRAATVPFPDNPSQVPYETLVENRKRGLHTLLLLDIRAKEGRAMLANEAIEI
MLGLEEKLRKNAFTPDTLAVVVARAGSDDAVVKADRVGKLRRLDFGSPPHVLIVPGKLHF
VEAEALRVFAGAPEAVAK
>A0A832CCF3|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylicus sp|TrEMBL
MGSLSFIGLGLSDERGMSLYGLELARSADIALIETYTNLMPSLNLRSLEALIGKEVNRVD
RHYVEDGTHLLRAASEKNVALLVPGDPFIATTHIELRVRAERRGIPVRVAHAPSIISVAP
GVAGLQNYKFGRSATITFPDNYSEVPYDTISQNRRAGLHTLLFLDLRAEEGRYMSVPEGV
QLLMEMESRRGEDVVSPDMLVIGIARAGSPDQLVRGGRAKDLASLDFGPPPHSLIVPGRL
HFMEAEALEVLARVERSLLSQYVERV
>A0A7K4DFR8|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
PVVAAGTGARLKEIDFGPPLHILIVPADLHPMEQEYLEVFAGL
>A0A7K4MLN7|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
LDILSKADIVYLEQFTSPIEKSDFDKIKNITKGEFKPAKRWLVEDGNEILQNAKKKKVVL
LSYGDPYIATTHIELRIRAIKEKIKTYSIHASSSLTSMIGECGLHFYKIGRIATIMSEMK
SLTTPYYLIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALNGLLETEKGQRRNVISSSTYV
IVASRIGFKDQSIISGKISSLKKKDFGKPPHTIIIPGRLHFTESDALKILVECIDDPFDN
SEKTKKISIQMIEKYVPMVKEALGEVEHHYKDQKEFQKILENAELYIQDAEKFLEDGQDE
VAILSIGYADGLVDALRLAKGLKRKM
>A0A7J4K7H7|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
LGTEEQIIKYGKINELLDIEINVYPQCIIIPGKLHFMEEEVLELYKIQ
>A0A7J4M1B4|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
KVRTEVIHNISVLNAITQTGLEAYKFGRVTSIPTWQDNYRPTSFYDILKENQKINAHTLF
LLDIGLELEDAISYLVKVSTDRGEGAFTKKTLCVACSCLGTKKQKIKFATAEKLARIKFN
KPISLIVPSHLHFVEEAYLKRFKF
>A0A7J4EB64|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MLTFIGLGLYDERDISLKGLEAIRDADVVYAEFYTSPLGGKTVEKMEKAYGKRIFVLERS
DVEENAEEGILKLAKNQKVVLLCGGDAMIATTHVDLRLRAMDIGIETRIIHAPSISSAVA
GLCGLQSYKFGKSATVSPPYKGVISEVPYDTTRANKERGLHTLLYLDISMRINEALRLLE
AVEEKRKSQMLKKSIIVGIAKAGSDKPVVKADYLNALKSYEFGELPHVLVVPGDLHFLEK
EALIKIAFAPEFI
>D7E9K1|diphthine synthase|EC 2.1.1.98|Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303)|TrEMBL
MLNFIGLGLYDEKDISVKGLETIKNADKVYLEFYTSHLFGTDIKKMEQFYGKKIHVLKRE
DVEQHPDWIDEAKEKNIVFLTGGDSMVATTHVDLRIRAIDKGIKTSVIHGASIASAVCGL
TGLQNYRFSKSTTIPFPYTTGRGKTIVSEVPYDTIKSNFEQGLHTLVYLDIDMDKGYMSI
NKGLEILQGIDKKRRENFINDKIAVGVARAGSYNPVIKADYISSLIDFEFGSPLHILAIP
GPLHFIEAEALVKLADGPEQILD
>A0A832S942|diphthine synthase|EC 2.1.1.98|Methanosarcina acetivorans|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQQPDWLDKAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGAIIISETPYDTIKQNSELGLHTMIFLDIDKDKGYMTA
NHALELLLEVEKRRGEGIMERAVAVGIARAGSEKPVVKADYAESLKDFDFGNPLHILVVP
GKLHFLEAEALVKLAAGPGKIMEETE
>A0A2D6Q5B4|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MTLHIIGLGLWNQKDISVRGLEIVRSCDAVYLEEYTSLLACSHSELEEFYGKEIILADRA
HSEQKVNEIINLAKEKDVAFLVIGDPVSATTHMEIVRSCMEKKVSVSIVHNASIFSAIGI
TGLQPYKFGKTISIPFLERVPNLETPYHMIKQNLSIGTHTLCLLDIMVDNVAAETGGKVA
DDAQNTKFMTVPEGLAVLEDIESRLKEGVIKEDTFVVGVARLGHDDFVVKAGKLSVVKEF
DFGGPLHSLVIPGKLHFSEEEMLQLWSDQK
>A0A514LBU3|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopumilus sp. SW|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPIGKSDLTKIKNATKGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKEKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LLETEKGQRRKVISSSTFAIVASRVGFKDQKIVSGKISSLKKIDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNAEKTRKISSQMIEKYVPMVREALEEVEPYYKDQKEYQVILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A662QPF9|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLIGLGLNVDGISKYGLSVVRRCKKVYLENYTVNFPYSFGELSAVIGKKIIPANRELV
EGLSIIDEAKKTDVAILIYGSPLTATTHISLLEEAKRLKIKYKVIYNASILDAVAETGLQ
IYKFGKVASMPKWNKEKKYEPDSFMKIVQENMSMKAHSLILIDIGLEFQDALKELEKAAE
NYKIKLKKIIVCQSLGTKNKKIIFREIKELKEYKGIKKPYCIIIPSKLHFIEKEFLKNFE
>A0A662U4K0|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MPWLAFVGLGLKLKHLTLEAIEVLKESDIIFLDSYTSVGENISAETLSSFLKKQVIPVSR
RNIEDENGKIIFDSLDKGLNVSFAVIGDPFIATTHIALLLQAVKKGIEVKIVHGISIYSV
AISCSGLMSYKFGKSATIVYPKEGITYEYFYDVIKENKKRGLHTLLLLDLDAEKGIFMRA
NEALRLLMEIERKRKERVILENEKVLVIARASLRDQKCVYGVISELLSKDFGPPPHVIIV
PGKLHFIEEEALRRFTIK
>A0A7C2V137|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLVIGGMGVGGPGNLTLSLLDAVRSSDQVFAEAYTDPEDMLTIKKVEELTGKKVIVLSRK
DLEEGQGDQVLEPAKKSPISLLVFGDPFIFTTHLALKRRAEQMGIEVKVVHGISVLSLAP
SCSGLDPYRFGPPVTVVYPDERYGYFPETPYEVIADNLSRDLHTLVLLDVKHEEGRYMGF
SEALGILEKLEEKLSKGALRKGRPLILLSALGSPREIVNWVRLGDVVDDKIYNLPKSIIV
PASIKFYEQVPPDFQRMLHRNG
>A0A662FQY7|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLYFIGLGISEKGLSIEALEILRRVDTVFLELYTSIIPDFKLDWLENMLGRKIRVVDRED
LEERGGEDILREAKVADVALLTPGDPFIATTHIVLRIEAERRNIKTRIIHSSSIITAAFS
SCGLQIYKMGRIVTITIPEPKVGYRPITPYLVLKENLERGLHTLFLLEIRAESGEFLTIP
KALELLEDMD
>F4B4Q3|diphthine synthase|EC 2.1.1.98|Acidianus hospitalis (strain W1)|TrEMBL
MLYFIGLGLAKKFLTQASIEAMRKVDVLYLDAYTSLSCDINKEYLEKLLGRQIILADRST
LENNSKNIIKLLKEGKSVGIATIGDPMIATTHVSLATEAKNKGYNVIIIPGISVHCYIIS
KSMLSSYKFGRSVTVVYPYDKILDTTPYEVIKDNSSRGLHTILYLDLKEGKPMSAKDAIS
LLLQMEEIKKEGIITPNTQIIIGQRLGCEDEEVKALTISEALEYKYKDTPHIIIVPSKNL
HYMEVEALKCLH
>M0PQ74|diphthine synthase|EC 2.1.1.98|Halorubrum arcis JCM 13916|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A2R6MQJ9|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_8_68_21|TrEMBL
GSLDAVVAADRLGALADREFGDPLHLLVIPGDLHHVEADALVGLAGASESLVEQ
>A0A7K4CK55|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLIFIGLGLYDEKDISVKGLEAVRAADNVYAEFYTSRLMGTSVERMEAFYGRKIHLLDRS
DVENDPVWLEEARDGDVAFLVGGDAMVSTTHLDLRLRAAKLGIRTRVIHSASIVTAVQGL
CGLQNYRFGRSTTIPFPYTSRGKRIIPETPYQVLKENLNRNLHTMLFLDIQSDPLERYMT
VNEGAALLLEMQANASEQILDGRLAIGIARAGSDDATVKADLLVRLKNFDFGGPLHIIVV
PAKLHFMEALALVTLAGAPPNLAVEG
>A0A2D6KWV5|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYIIGLGLNNEKDITLKGLEAVKGSDYVYLENYTSALNCSVKDLEKLYGKKIILADRD
LIENKAEQTILKDAKSKNVSLLVIGEPLSATTHIDIMLRAKELKIKVNIINNASILTAAG
ITGLQLYKFGQITSIPFDNKDIKTPVEVLKKNQKAGLHTLFLLDLNPEKKEFLSINKALE
YLVRNKVSKETLCIGCAALGSESPEIKAGKIKEVLKAKFKKYPQCLIIPGKLHFMEEDAM
EIYSIST
>W7KWM6|diphthine synthase|EC 2.1.1.98|Candidatus Aramenus sulfurataquae|TrEMBL
MSYLYLVGLGLSKRFLTKKAMDYLKDSDLIYFDTYTSFSCDLSAESLEELIGKRVIPATR
ALLETGFKEIMSHLESGKNVAIASVGDPVIATTHVSLAVEAKNRGHEVVVVPGVSVHCYI
ISKSMLSSYKFGRSVTVVYPYNDVIDYAPYYVVKENREHGLHTIVYLDVKDGKFMDAREA
LTYLMKMEEKRKENVISREDVVVVGQRLGCDDEKVIAKTVKDVLEGNLDLSPPPHIIIIP
ARNLHYMEVEALKCLH
>A0A842SU61|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
ITLRGLEAIRNADIIYLEHYTAVQHTKKEELETFFNKPIVLANREMVEVGGGNIVDEAKE
QDVAFLVVGDPFGATTHTDLFLRARKKGVHIEVIHNASILSAVGVVGLELYKYGRTTTIV
FPEDGWVPASSYDVIKKNQENYMHTLCLLDIKLAEPTKEDILRGVDKPQPPRFMTIKEGL
AALKEMEKQQKGAVVTDDTLVIGVARIGGVNDVPMVKAGTVKELMGTDFGEPMHSLIIPA
KKLHHVEEEMVRQWT
>A0A2D5V172|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLTFVGLGLGSAKDISLRGLEIVKGADLIFFESYTSLLECSVKDLEELYGKKVVLADRE
LTEKRADEILGPAKEKRVVFLVVGDVFSATTHTDLLLRAKKEGIKVDVVFNASVLTAVGL
TGLSLYRFGKTASVPFPEKSFFPEAAYDVVKQNLSCDLHSLLLLDIKADVDRYMTVKKGI
DILLELEAKRKEGVIRKDMLCVGCSHLGSDNVIFSGSLEEVREFDFRGPPQVLIIPGSLH
FVEEEAVKGFRETKSL
>A0A7C4RLI5|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGIGLNDEKDITVKGLEIIKKCKYVYLESYTSILQVPVSVLEEFYGKRVILADRA
MVERRANDIIIDAKEHDVAFLVIGDIFGATTHTDMVLRAKSYGIKCEFIHNASIINAIGV
VGLELYKFGKTTSIPFPEKGFKPETYYDVLKMNKEMGLHTLILLDLKLQEQRFITVNLGI
KYLLEINASRGDDVFNENTMVVGCARIGGNFHIKYGKAKDLLNHDFGKPLHCIIVPGKLH
FIEEEALKQWE
>A0A2E9U5M8|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGIGLNDEKDISLKGLELVKKADFVYLENYTAKINCNLSYMKQLYGKKIILADRK
LVEMDAEKTILQQAKTKEVAFLVVGDVFSATTHMDLFLRAKKAGIKTRIVHNASVFTAIG
VTGLQLYNFGKTASIPFLNENIETPYDVLKLNQKNNLHTLFLLDVKENSNDSLTVTDAIR
YLLKVELKRNEKVFTDNTLCIGCAKLGSLDQIIRAGNAKELLQYLFKGGMHCLIVPAKKI
HFMEEEALKLYF
>A0A3M1F6U7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGIGLANEEDISVRGLTSIKTCEHVYLEGYTSILESGKDRLEALYAKPITILDRD
DVEKGCERMVEQAKTKNVAFLAVGDVFSATTHIALYLEAKKRNVPVTVIHGASILTAVGK
TGLELYKFGKTTSIPFLHENVTTPYTVLVTNKNAGLHTLFLLDLTPNKNRFLTIPQAARY
LLEQERQQRKGVVDETTMGVACSRLGWSDETITYATLHALATERVPTGKPPSCLIIPADL
HFIEEEALAHYSR
>A0A3M1FF33|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALNIIGIGLNDEKDITLKGLELVKNSDEVYLESYTSKLQCEISELEKLYGKKVNLANRE
IVEQKAEDVLLNPAKEKNVSLLIIGDVFAATTHVDLMLRAKQSGIKVNIVHNASVLTAIG
ITGLSLYKFGKTTSIPFENENVETPYNVIKENNKMHTLILLDLRPEENRFMKFTEARDFL
LKIESKRKENVFTEDTLCVGCAKLGSTEPVIQVRKAKELEEVEAHPQCLIVPGEMHFMEE
EFLMK
>A0A4U7CPN3|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SD690R|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A2V4H9F3|diphthine synthase|EC 2.1.1.98|Thermoplasma sp. Kam2015|TrEMBL
MLNIIGIGLRGTGSITFDEFDALRTSDLVYIDQYTSIGQPGLVKKISSMLDREVIPLNRE
DLENGSILKPAMDKNVSLIVIGDPLMATTHNEIRFEALNRGIKVRLFENASIINTAVGKA
GLMIYKVAPPVSLPKVNEKFFPMSVIDKIKRNLEIGLHTPLLIDLDGTENIPLHDAIESL
IEMQNRRGYEGLIDEVCILSRVSFQDERIIFGKIDDVMHENAASPYMIIILASLDDNERR
FLSAFSRSSMKE
>A0A328S538|diphthine synthase|EC 2.1.1.98|Methanosphaera sp. rholeuAM6|TrEMBL
MLYFIGLGLFSEDDISFKGFNALKNVDCIYAEFYTAKLMGGNIDNLISKVDVPFVTLKRE
DVEDRNVVLEEALTKDVAFVVAGDPLMATTHTELYVEAVSKGIETRIIHGSSIFSAAPGL
TGLQAYKFGKTTTVPFPDENFFPHSPYDVIKANKNIGLHTLVLLDIQAHKDRFMTINQAL
DYLVKVESERKEEVFTDDTIVVGLARAGSDKPLVKGGIVKEVANYDFGGPLHCLIVPGDL
HFVEAEALIVLSDISKDLLEEFL
>A0A7J4U1V8|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MPLIVTTGQDGISMTVDLPPTGLLLVGLGPGGRSGMTAAAIEAAQTADHRWYEAYTALWP
EQDVIDLEAHVGPIERVMRPDVEHPTEMFELARTSLVALLVVGDPLQATTHVDLQLRAED
AGVPCRVLHGLSITGMVTGAAGLSNYRFGRQTTLTYPHGAWIATSPLETIALNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHMMAERLAERPPEEGALSSLTSADLEGLDVGA
WTVVLCADVGTSDEAFVTTTVDGLPSEVGGRLNCLLVPAAIEGVEAAAIARWRRS
>A0A7J4TPX3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
AEAVEAAKAADVRRYEAYTALWPRSELDALEAAVGSIEKVMRPEVEQPDVLFELAHTSLV
ALLVVGDPLQATTHVDLQLQAAEAGIECRVFHGVSITTLVTGAIGLSNYKFGRQTTLTYP
YGGWVATSPLEVIAVNMHQNLHTLALLDLDPTGEGVGNQVPMKPSDALVSLRLMWDKLGQ
MLDEMPRETALEAMRHEACAVFLARSLDDVHVVLCADMGTDDERMVATTVGALDGIEGGR
LNSLVFQSTASEVEERALLRWE
>A0A662KK55|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLSFVGLGLWDERDITVKGLEEVRNCDVAYAEFYTSKMGVGIERIEELAGKKIHVLSREE
VEDGERILREAEKKHVCLLAGGDTMAATTHVDLRIRAVERGIPTRVVHGVSIVSAAAGLL
GLQVYKFGKVVSIARPQPNFFPLSPYDAIRDNMTMGLHSLLLLDTTGGYMTANEALELLL
EMEERKRENLIGEDTPIAVVARISSDDALARAGCLGELRKQDFGSTPHSVVLFGKLHFME
VRALVTLAHA
>A0A662MHQ0|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGTLYLIGLGLCDERDLTIRALEVLREEVSEVYIELYTARPKGLNVQNLERLIEKKVNVL
SRELVESNYLLNRAKEKNIALIVPGDPLVATTHISLILDAKRMGIKYRIIHNASVLTAIP
GACGLHAYKFGRTTTLPYPYKGYIFESPYDVIKENLRRGLHTLVLLDLNPEKGSSMTINE
GIEILLKIEERRREGVIRNDSILVGIANVGSEDEIIKAGYPRDLIEYDFGEGMHSIVVVG
NLHFTEAEALVYLADAPREILEDA
>A0A7J3TCM7|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLNLIGMGLRGVQSLTIQEDEILKRSHRIYFEAYTSIAPENTINELESRYSRSVKPLARI
DVENPEEIIKESLDGIVSLIIVGDPLTATTHNQLRLEAQNSGVEVKCYENASIITAAFGY
TGLFTYRMSPPVSLPFPHEKFFPRSVYDKISKNIEDRRHSLILLDLSPGKGMKISEAVKY
LLEMENRFGTGLLTEDRELIAISDLGHSDEKIVMGTFRSMTSYEGGKINCIILPERPTED
EVRFMSMFCRKLPL
>D2PJV0|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)|TrEMBL
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>A0A7C1B6Q7|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MSKGEILFIGLGLYDERDISIKGLEAAKTCDKLFAEFYTSKLSGADTSKLEKIIGKPIIV
LERNDVEKGEEILEMAGKSRVGFLTAGDPMAATTHVDLRLRAQERGIETRVIHGSSVFTA
VPGLLGLQHYKFGRSTTL
>A0A8J8PMN3|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. A20-N-F8|TrEMBL
MGVLNLVGLGLAKKFITKSAVDALLNSDFIFFDRYTSKSCDINTDSLKEILNGKDVIEAN
RDLLENNSKIMLNYLDNNYKVSIATIGDALIATTHVSLALDARKRGHIVNVIPAVSVHCY
IVSKSFLSSYKFGKSVTVTFPYDNFIDYGPYHVIRDNKERGLHTIIYLDLKDGKAMTAND
ALNILLSMEDKHRMNVISKSNIVIVGARLGCENEKVIAMTVEEALNYDFGDTPHIIIIPG
TLHYMEADAIKWMLMT
>A0A0B5HLA2|diphthine synthase|EC 2.1.1.98|Archaeon GW2011_AR15|TrEMBL
MTLYMIGLGLNDEKDISLKGLEAVKECDYVFLEGYTSRLNVSLERLENFYGRAIVLADRE
MVENNSDQIINKAAASNVAFLVVGDIFSATTHIDLFLRAKEKGIQIEMIHNASILTAVGS
VGLELYKYGKTTSMPFFEPSFEPETPYDVIKMNLKNGLHTLVLLDIKPDRFMSVNHALAQ
LLEIENRRKEKVISEKTGVIGCARLGSRNQLIKYGSVHELLDFDFGGPLHCLIIPGKLHF
MEEEMLRFWEINQSD
>A0A842X8A1|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MWNLISLVGLGVGYDITERGMELLRECDVAFCERHTMPVPEEYIKTLEEKSGKRIETIGR
EDVEGEDPLVLKEAKERSVCLLCGGEPLAATTHISLLVDARKAGIGTEVVHNSSVFSAAA
GKSGLQQYKFGKTVTVSFWRKNYEPTSPLLLIEKNIGGGMHTLVLMDLDAELGLMDAKLG
LGLLRKMEEKEGRKVLPEKVVVLSRLGYPDEKISYGKISELVEGELGEAPFCIVVPGELH
EMEREYLELL
>A0A7C1X2S5|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGLGLYGLRDLTLGVLEYLRKADRVFVELYTSILPRFDLRKLEELAGKRVTTVRRA
ELEGAWLRELLKIAEQELVMLLAPGDPFIATTHMSLRLEAVKRGIRVKVLPSPSVINAVA
ASTGLDFYKFCRPVTIVKPSVKYSPSTPYHVLRDNLTRGLHTLFLLDLDVEKGYAMTANE
AVDILLELDKREGGRMLDENTLFVAVARATSDDEIVAAFTPTQRPELGPPPHLLIIPGIL
NPVEAEALQHLAGAPPELLKNWCSKLKLWRSTANPCVHH
>E7QRX3|diphthine synthase|EC 2.1.1.98|Haladaptatus paucihalophilus DX253|TrEMBL
MLTFIGLGLYDERSITVEGRDAIADADRVFAEFYTSKLIGADVTDLEAFHDTDIEVRDRA
GVEQHPDDILAAAESGDAAFLTAGDTMISTTHVDLRLRAEDRGIDTRVVHAPTAESAASG
LTGLQNYRFGKATTLPFEYAHGADGLPASVTDVLDDNRERGLHTLVYLDIKVGWNPRKED
EAGEDEYMTASHAAELLADGYDDVLAVVVARAGSPDPLVEADRLSELAERDFGDPLHLLV
VPGDLHHIEADALESLADAPSDLLDVV
>A0A650CSZ0|diphthine synthase|EC 2.1.1.98|Acidianus ambivalens|TrEMBL
MLYFIGLGLAKKFLTQASIDAMRKVDVLYLDAYTSLSCDINKEYLEKLLERQIILADRST
LENNSKNIIKLLEEGKSVGIATIGDPMIATTHVSLATEAKNKGYNVIIIPGISVHCYIIS
KSMLSSYKFGRSVTVVYPYDKILDTTPYEVIKDNSSRGLHTILYLDLKEGKPMSAKDAIS
LLLQMEEIKKEGIITPSTQIIIGQRLGCEDEEVKALTISEALEYKYKDPPHIIIVPSKNL
HYMEVEALKCLH
>A0A7C4S0Q7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLVFIGLGLNGLADLTLSGMEWICKGDKIYLDTYTSIIPNFSIKELEDFSGKSIIPVDRK
TLEINYEKILSEAKNGIIILLSPGDPFVATTHIQLRLAAINAGIETKVIHSTSIISAIFG
ETGLSSYKLGRIVTITFPFGKELSETPYDVIKDNMSRGLHTLLLLDMDLERKLFMKIGEA
IDILRMIEERRRENVVTKKTLAVGCARVGSNTQIIRANYIYDLAKEDFGDPPHSLIIVGK
LHFMEAEALVKLAKAPKEILEV
>A0A7C7IPS3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTHLSRTREKPCSLDDDGGLVMVELDSGLWLIGLGPGDLSAMTTAAIESAKSCKYRFLEG
YTALLPPDEEGKLSDMVGEYELLMRPDVENPDQLLKLASKSAVALMIVGDPLQATTHVDL
QLRAKAAGITCHVVHGISITTIVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNL
QRDLHSLVLLDLDPTGMGIDEQKPMSPAVAVDVLRRSAEKVGENIQQWKIVLCSDMGRPE
QRIFYGTLDDVKSINDGSIHCVVIPGRLDELEAEALSRWN
>A0A2A2HBA4|diphthine synthase|EC 2.1.1.98|Methanosphaera cuniculi|TrEMBL
MLYFIGLGLFSEDDLSVKALNALKSVDCVYAEFYTARLMGGDINNLMDKIDVDFIELKRE
DVEDNNIVIKEAMNKDIAFVTAGDSLMATTHTDLYVEAKNRGIDTCVIHGSSIFSAAPGL
SGLQGYKFGKTTTVPFPDEGFFPHSPYDAIKLNSDNGLHTLVLLDIQAHRDRYMTVNEAI
DYLRRIESERNEGVFSDDRIVVGIAHAGSDEPIVYGGKVCDVLEHDFGGPLHCMIVPGDL
HFMEAEALITLASVDKELLEDYL
>A0A075I2Z4|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote KM3_89_E01|TrEMBL
MTHHTRKSDKHYSLDDDGGWTMTNFESGLWLIGLGPGDLSAMTTASIEAAKSCNYRFLEG
YTALLPSGEGAKLVEIVGEYELLMRPEVENPDQLLELASENAVALMIVGDPLQATTHVDL
QLRAKAAGINCHVIHGISITTIVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNL
QRDLHSLVLLDLDPTGMGVDEQNPMSPAMAVDILRRSADKIGENIEQWEIVLCSDMGRPE
QRIFYGTLDDVQLINNGSIHCIVIPGRLDELEVEALARWN
>A0A2R6EGR5|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_1_67_19|TrEMBL
MLTFVGLGLYDERSITVEGREALADADRVFGEFYTSKLLGATVEELEAYHGIDIEVRDRA
GVERDPEPVLRAAADGDAVFVTAGDTMISTTHVDLRLRAEQRGIDTRVVHAPTAESAASG
LTGLQNYRFGKATTLPFEFAHGAEGLPASVTDAIDENRERGLHTLVYLDIKVGETPTGSR
NDSSADTADRDEYMTADHAAGLLAERYPDLLGVAVARAGSPDPIVSADRLSALAERDFGD
PLHLLVIPGDLHHIEADALRELGDAPEELLEVE
>A0A1F9YQK4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon RBG_16_62_10|TrEMBL
MGPDAPEGRLVFVGLGLGDEDGLSIAGMKELEAADVVFAEAYTSTLRPGALQRLEARSGR
KIELLDRAAVEGGARIMDESERKRVVLLVAGDPMAATTHVDLRLRAAKRSIRTAVVHGAS
ALTAVPGLLGLQHYKFGRATTLPYPQEGFSPTSPYEIIAENLARGLHTLVLLDIDAENSR
YMSANEGMHLLLDMERRTGKRVISGDTLVCVVARAGSLDAVVRAGRIDDLVSDDFGPPLH
TIVVPGKLHFMEEESLAVFAKR
>A0A497IHX8|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFIGLGLYDELDVSLRGLEAIRSADKVYAEFYTSRLTGTKIEQLEELYAKKIHLLDRE
DVEGSPEWIKDAINHEIVFLTGGDAMVSTTHIDLRLRAEKLGVRTEIIHGASIISAICGI
TGLQNYRFGRSTTIPHPYTTRSGKTSVSHTPYDTIKQNQESDLHTLMFLDIDREKGCMSI
KQGIKLLMQVENERNEEVISDYTLGVGVARAGSAREMVRADYLRELERLDFGRPLHTLSI
PASLHPIEAEALVAFTDAPKEILHNI
>A0A662R1E2|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGIAAIRDADLVFAEFYTSWMMGTTIERMESRYQKKITTLSRD
DIETDPSWLHHAIKSDVVLLSGGDPMISTTHIDLRLRASDLGIATAIIHGTSIVSAASGL
SGLQNYRFGRSATIPFPYRVRSKTIVSETPYNVILSNRDADLHTLLFLDIDSEQGFMTIP
QAVQLLMQVDEKRLLKGVLGVGIARAGSRDVVVRCDYLYDLAGFDFGAPMHLLIVPAGLH
QMEAEALIRFAGAPEEVRNSGR
>A0A830EFA1|diphthine synthase|EC 2.1.1.98|Halobellus salinus|TrEMBL
MLTFIGLGLYDEESITVDGRAALEDADRAIAEFYTSHLVGATVAELSASHGIDIEVRDRA
GVEQDPEDVLAAAENDHVAFLTAGDTMISTTHVDLRLRAIDRGIDTRVIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPDARGGDAVPGSVVESIEANRERGLHTLVYLDINASRDEYMTA
DVAAGLLTEGWTDTLGVAVARAGGPEPVVAADTLSALAAREFGDPLHLLVIPGDLHHIES
DALSALGGAPADALAARER
>A0A0B3AKG9|diphthine synthase|EC 2.1.1.98|Archaeon GW2011_AR5|TrEMBL
MLYLIGLGLWDESDISLRAIDALKKCDEVYLETYTNKWLGSVRHLEEIIGKEVKHLKRIH
VESDMLIDIAKETDVALLIPGDPLVATTHIQLMIDAKAKGAAFDVIHSSSIYTAVAETGL
QLYKFGRATTLAFIEKSFKPSSPYEMIMENRKMGLHTLVLLDVKEDNRYMTIADGIYVLN
QLGMDDIKIVACCQLGSESQKIRYGNMKELSEDASLAETPAAIIIPGRLHFKEEEALRMY
EK
>A0A2E4JS19|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLLLVGLGIYGYAGLSVKALDSLLSITNIYVEKYTSPMLESEIDNLKQILNKEVKVVPRW
FVEDGREILQLAKSNDIALLVYGDPLIATTHIDLRVRAENNGIKTRVLHATSSITSIIGE
CGLHMYKIGKIITLTSEIQSISSIYYTVYGNILSGNHTLVLLEYNQEKNLFLNPNNAFEM
LLKSEIDQKYNVFSTETFAIVASRVGSENQSIVSGKIKSLIETEFGEPPHSLIITGNLHF
TEIDALRVLIKTIDEPTDNSKNIMKIAEQMIMKYVPKARKALEHAKNLVNDDTSFNDIFE
NAEYYISDAEKFLQQDKPELAVLSIGYAEGLIDTIRFLKGVNMWE
>A0A662QAQ6|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLRWRHEGLGELIFVGLGLFDENDISLRGVEEAKNADVIFAEFYTSILAGLSLDRLEEIV
GKRIIVLGRRDLEDECGESILRAAENGRAVLLVPGDPLIATTHIDLRIRAEKRGIKTRIV
HSASIVSAAMGLSGLQNYRFGKSVTIPFPVNGRVSRTPYDVIAENKSRDLHTLCFLDLDV
EGGRYMSIREALKILLSLEDDIGGGILGLESLAVGISRAGAKDGIVKAGSIRELLNFNFG
DPPHTIIIPSDNLHFMEAEALSVLADAPKWIKEMIK
>A0A533US11|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFIGLGISGIDGISSSTLKIIKKADVIFLENFTSPIGKQEVSKIEKLVRRKFKIAPRW
MVEDGKTILLEAKRKTVVLLSYGDPYVATTHIELRTRAETEKIGTRTIHGASAITSLVGE
CGLHHYKIGRPVTIMREISSLTTVYYTIYENLIRDSHSILILEYNSDTNFFLGPKEAFSN
LLLTEGSQKRNVINESIFAMVASRIGTKNQSIIAGKLSSLMDADFGKPPHTIIIPGKLHF
TEDDAIKTLAKCLDDPSDNSSKIQKISQQMLLKYLPKARKALEEVQRQFKDNKDVQPIIE
NAHLYLDDAEKFQKEGKDELAVLSVGYAEGLIDALRLSKGIDPWAQSL
>A0A5N5UKM6|diphthine synthase|EC 2.1.1.98|Halosegnis rubeus|TrEMBL
MLTFVGLGLWDEDSITVDGQRALRAADEVFAEFYTSRLMGTDPESLATHHGVDIDVRDRA
GTEQEPEPILDAAESGDAVFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGTTASAAAAS
LTGLQNYRFGKATTLPFPYAHGGDGVPNSVCDTLDANRERGLHTLVYLDIKQERGEYMTG
DVAADLLADGYEDVLGVVVCRAGSPEPRVEAGRLSDLANRDFGDPLHLLIIPGELHYIES
DALRELAGAPEELSEPV
>A0A3A5WNT5|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MVLALSKRLGGLSMAEKMDGQESFPKTGLLLVGMGMGSLSGMTVEAQSAAKAADHRRYEA
YTALWPEDELARLEERVGSIQRVMRPEVEEPEELFALAERSLVALLIVGDPLQATTHVDL
QLRALDAGIDCRVIHGISITTVVTGAVGLSNYKFGRQTTLTYPYGDWIATSPMEVLASNW
EQNLHTLALLDLDPTGLGTGDQRPMKPEDAVQSMRLMWEKLQEKADEXLSDDYVRLAFRQ
MATKLYLQQNFDDIPVVLCADMGTPEQSIVTTTLGALGEEKGGRLNCLVFPAGTGEVEEK
AVLRWKRGE
>A0A1V4YJD3|diphthine synthase|EC 2.1.1.98|Methanomethylovorans sp. PtaU1.Bin093|TrEMBL
MLTFIGLGLFDEKDISLKGLEAIAQANRVYAEFYTSRLMGTTLEKMEGLYNKKIQVLSRE
EVEQCPSWLEHARNENVVFLTGGDTMVSTTHVDLRLRAMEMGITTKLVHGSSISSAVCGL
TGLQNYRFGKAVTVPHPYTSSRGKTVISETPYDIILQNLEHGLHTLVFLDIDKEKGYMTV
NQALDLLLQVEAKRSAKILQDRIAVGIARAGSDSPAVAADHIQSLKDFDLGAPLHILVIP
ADTHFVEAEALVQLAHAPMSILEVHKQ
>A0A432HIG7|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTERARSVARGCSKRYLEGYTAVLPQREEERLESVIGPWERLMRDKVEKPVELLASARSE
AVALLVVGDPMQATTHIDLEARCAEQGIGFYVIPGLSVTALAVSLSGMQSYRFGRQVTLP
FAVGDYLPTSPLEMLCNNFESGLHSLVLLDLDPTGMGVERPRPMSPAEAVGLLEKMVERL
EGGEDGLRASLERPVREWSGILLSDLGTEQERVLSGQRGDLDVSGRAYLEAVPAGASCAT
QQVCAFSCHMSDTTDLEVEKTAKSADCKPGSTCTYTITMSNTGATPRSGPFSIRELLPNG
ATFVSVSPLPWTCAPDGASPANDVVCKYPPGMP
>M1JCV0|diphthine synthase|EC 2.1.1.98|Sulfolobus acidocaldarius Ron12/I|TrEMBL
MGVLKLIGLGLSYKFITEIALNELRTSDVVYADTYTSLTCGDLISRLHQLGINPIPVGRD
FIENNYKKILELLDQGKSVGIAVIGDPMIATTHISLVTEARTKGHQVSIIPGVSVHCYII
SKSMLSSYKFGKSVTIISSTDYGKIDTTPYKVLKENLERNLHTIFYLEPNMSARDAVSLL
LQMEKIEEQGIINEDSLIIVGQHLGCDDEEIVSLKIKEIAKYNLKSPPHIIIFPSKSLHY
MEIEGLKWLMK
>A0A328SJK6|diphthine synthase|EC 2.1.1.98|Methanosphaera sp. rholeuAM130|TrEMBL
MLYFIGLGLFSEDDISIKGFNALSNVDVIYAEFYTAKLMGGNIDNLISKVDVPFVKLKRE
DVEDKNIVLEEAMSKDVAFVVAGDPLMATTHTELYVEAKSKGIDTRIIHGSSIFSAAPGL
SGLQAYKFGKTTTVPFPDENFFPHSPYDAIKSNLDMGLHTLVLLDIQAHKNRFMTINEAI
DYLSKVESDRNEGVFADDTIVIGIAQAGSDNPVVKGGRVCDVAGYDFGSPLHCMIVPGNL
HFVEAEALITLADIPEKLLEKFL
>G0EF60|diphthine synthase|EC 2.1.1.98|Pyrolobus fumarii (strain DSM 11204 / 1A)|TrEMBL
MPLFIAGFGTSIEYVTLRLLDVLREADKVYIDAYTSIAPGLDADSVARLAPRAEIVIADR
KLLEEKQSVIIEEAREKNIVVLVPGDPMLATTHVTLRIEAVRRGVSVELIHGVSGLQAVV
SYTGLQVYRFGRTVTLVYPEEGFKPYSTVEYTWENLDRGLHTLILLDLRLDQGRAMSINE
AIPILLELEDELVSQTGRKERLIRDSILVGVARAGTREAKCRAGKAEEVASEAYPPPPHS
LIVTAPRLHPIEEEALHLICNLGVARHGPKTR
>A0A1D2WEW3|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. A14|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSYLMGTNLEKMEKLYGKKVFLLSRE
DVEQHPEWLSEAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGSSIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIMRGAVAVGIARAGSEKPVVKADYAEKLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAEAPAGFMNEAE
>A0A0H1QYX9|diphthine synthase|EC 2.1.1.98|Methanoculleus sediminis|TrEMBL
MLTFVGLGLYDLGDISVKGLEYVRNADTVFLEAYTSRLMGADVGAMEAFFGKEIRVLGRE
DVEQNPRDILDCAAAGRVAFLTGGDPMVSTTHADLRMRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPIETIAANLAQNLHTLVYLDIQNDRYMRVPEAIA
VLEEMAQKRGIEPPALYVGIARAGSERPVVAAGTGATLKETDFGPPLHILAVPADLHPME
REYLETFAGL
>A0A7C3Q309|diphthine synthase|EC 2.1.1.98|Candidatus Nanopusillus sp|TrEMBL
MFILAGLGMNIEEIPCSVLEVIKKADYVFLEIYTNIPSKKLLEYLMNLRKDIKIVYRKFV
EEELEDFIIKNKEKTIALLVFGNPLFATTHISLLKFCKENKIDFKVILSSSIYDHIAKTG
LFIYKFGKTVSIPFHESDIPYKVIKENLSIGAHTLLLLDIDTEKSKYLSIREAIERLISL
ENKFREGIIDLNKKIIICERLGFEDEKIYYVSLKKAMEFEYNYPVCIIYPSDLNPIEKEI
LKCMSYFYEE
>A0A7C3M315|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGLCDENDITLRSLKILKECEKVYFESYTNLWFGDLKKLGKLIGKKIKRLKRKD
LEENFDQILEEASKKSVAILVPGDPLVATTHSTLILEAWKRKIKTRIIHNSSIISAIAET
GIHVYKIGSILTIPLKEKVELPISIYQKIKESKERGLHTLCLLDLDLEKQRFLSVKKALE
ILLQLEKRFKEKVISEEEEVVIASKLGCKDSKILFGKIEKFLNLKVKVPAAILILGKLHF
MEKEFLEKFRLT
>A0A497T6Y6|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGIWDEKDISLKGLEACRKADKIYAEFYTAKRGGSFQNLEKIIGKKIEILKRKD
MEEDSEKILNESEKKNVVVLVPGDPLAATTHIHLISEAKKLGIPFQIIHSSSIFTAIGET
GLSLYNFGRVVTLVNWSEKQKPTSFYEYIWKNKKTGLHSLILLDIDMDISEGLKLLLESE
KSIKKGLFKPETKVVAASKLGSSGQKIIYGFVEKLVSLNLEAPGVIILPGKLQFFEEEFL
ETLKI
>A0A7J2HBA9|diphthine synthase|EC 2.1.1.98|Archaeoglobus veneficus|TrEMBL
FKGYEVVKRADKVYVEFYTSILMGTSIKKLSSFFGKEIKLLERKDLEEESWKIVEEALKL
NVVILTPGDPMVATTHSALKLEAEKKGVKTSIIHGASIVSAVCGLTGLHNYRFGKSATVS
YPYKGKVSKTPIEIIERNWSIDAHTLLYLDLHPKPMSINEALEILLKIKDIKDSFAVGIA
RAGSSNPIVKCNRIGKLLHENFGKPLHILVVLAKTLHFMEFECLRKFANAPDELEKLVN
>A0A2R6G5X2|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_1_68_20|TrEMBL
MLTFVGLGLYDERSVTVEGREAIRAADRVVAEFYTSRLVGATVADLETAHDVDVEVRDRA
GVERHPEDVLDDAEDRDVVFLTAGDPMISTTHVDLRLRAADRGVDTRVVHGVTAETAASS
LTGLQNYRFGKATTLPFEFAHGGDGVPDSVIETIDANRQRDLHTLVYLDIKVDDPAAPED
GEEFMTADHAAGLLAADWAGELAVAVARAGSPDPIVAADRLSALAERDFGDPLHLLVIPG
ELHHLEAEALASFGDAPADLLPE
>A0A847SQU7|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccus sp|TrEMBL
MGELIFVGLGMSRAEDMSVRALTTLRNCDEIYAEYYTSKLNDASHRDVEAFIGKKVTVLK
RGDVEEKDVIIKAARERKVAFITAGDPMSATTHLDLRLRAVEEGIVTDLINGVSIFTACS
AALGLQPYKFGRTVTIPLPEQGFLPSSPYENILENHSRGLHTLILLDIKAEENRYMTAPM
AMQWLMDAEDRIGSGLVKSNSLFCAAARVGSPNQALFAGYPDEILTVELGPPLHCMVMPG
RLHFMEARGLVTFANAPRDILDEGGSGSESQK
>A0A524I2U9|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccus sp|TrEMBL
MGELIFVVLGLGGTDDLSTRAVNALKECDQVFGEFYTSKLIDSTPDELESLIGKKIVRLS
RREVEEEEIVIEASKKGKVAFITAGDTMAATTHVDLKIRAMEDGVKTTLIYGISIFTACS
SALGLQPYKFGRTVTIPFQEPGYTPLSPYENIFDNWSRGLHTLVLLDIREEEDRYMTANQ
AVEWLLAAEKAVGKGMITDKQIICAAARVGSRTEKVAANYPQVMLNEDMGPPLHAVVVPG
KLHFVEAYALVKFAGAPDEIAEDQNL
>A0A7C7T3I5|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopelagicus sp|TrEMBL
MLWFVGLGISGGESIPVEVVKVIQNADMVYLESFTSPIYKHNEEKLKSLTNGNFKIAKRW
LVEDGQEILRTAKVSNVVLLSYGDPYIATTHIELRTRAKLEKIETKTIHSASAITSMVGE
AGLQFYKIGRIVTIMNEKKSLLTPYTTIFKNLLQGLHTILLLEYNEVENYFLNPKNAISD
LLEVEKEQKRNVVNENTFAIVASRIGFKTQMITAGKFSNLLKINFGEPPHSLIITGKLHF
TESDAMKVLTECLDKPLDNSNEIKSISIQMIEKYVPMVREALEEIKPFYNNVKEYQEILQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIEPKM
>A0A7C5YSR5|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MLKLIGLGLSIDLLPIGNLLKLLKCNKILLDRYTSIWFSNNLDISEIFKKYGIEVIHASR
KDLEGENIDNIVEEAKDKDICIAVPGDPLIATTHSAIAIEALKKDVLVEIAPASSILNVG
ISMSCLQIYRFGKIATVIKPKNGIEYEYPLQIVKLNRSLDLHTMLLLEMDIEKNYFMTPK
EAIEILINIQKRWGEEIIIPNDIVIVLQAITSSKGKAYTITVNDILKEVIEFKEPPYTII
IPARKLHPIEKECLDNIEKLSYTSYIKYIDINKLLESISI
>R9SMC1|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp. AbM4|TrEMBL
MFYLIGLGLFDINDMSIKALNALKEVDVIYAEFFTSKLIGSTLEAIEDKIGSKIHILNRS
EVEEDSPFILEAKNKDVALITGGDPLIATTHSDFLVQCVRKGIDYRVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFQDHNFFPKSPYMAIKENMDMELHTLVLLDIQAHKDRYMSINQGL
EYLMKVKDTLPEEEQVINEDTLAVGIARVGSDEGIVKAGKISELIDYDFGSPLHCIVIPS
KLHIVEAEYLVYVAGADKSILEKC
>A0A843G4Q5|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGVEALKKVDKVYAEFFTSRLFGSNFEKIESIIGKDIIVLDRT
QVEEESIFLEEAKDIDVALITGGDPLIATTHSDFLVECARKGIDFEVIHGSSILSSAPAI
SGLQAYKFGKVTTIPFPDLEYNYFPKSPYIAIEENLKMDMHTLVLLDIQAHKDKYMTVNE
GLENLMTIKDNLDHEGLVNEDTLAIGIARVGSKENLVKAGYIKDLIDFDFGGPLHCIVIP
SKLHIVEAEYLVEVAGAPREILDDI
>A0A3M9ZQR0|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon S13|TrEMBL
MLTLVGIGVGGARSMGAGAREAIASARAVYMETFTSPVPAGDVEEVRRAAEEGGAAFRAV
PRWAVEDGGEILRAAASGDVALVCYGDPYVATTHIELRARAAAAGTPTRSVHGASALTSV
VGECGLHQYKVGRTATVTRAEASTPYGVLRENVERGCHTVLLLEYDEDAGAFMAPREALA
ALLAVEGERRELALTRETFAVIASRVGTAGQAIAAGSVDHLMGLDAGEPPHSIVVPGALH
FTEADALRALARCEGEPRSNSETARREAHRMLARYVPMVGAAMREARERGADERVLDCAR
DYVADAEEFLRRGREGQAILCIGYADGLVDALRIGAGLEREDGAPDRG
>A0A838D6A7|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLYIIGIGINEFESLSLGSMEILKNSDIVYVERFTGFISDEFVNNLSDILRITNDSRSTN
DIEIKFIKRWFIEDGRKILENAQNSNVCILVYGDPLVATTYNELLVRAKKQSIEFKVVHS
SSGILSLMGESGLQPYKFGKMVTMMDDPMSSITVYNTIYENMCLGLHTLILTEYNNDDGK
NNFQSSSNPFFLSPSRVIDLLLEREKEIKLLNFSVETYGLVATKIGHKESTFSSGTIKSL
LKLEYSGGPNSIIIPGKLHFTEVDSIRYLTSMIDEPTDNTERISILAHRMLNKYIPNTKV
AVDNMYQLIKTELSGLSKDYAPVIENAENYLLDAQIFYNQGKLELAILSVGYAEGLIDSI
RFQKNMNPW
>A0A3M6KAE3|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPISKSDLSKIKKATNGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKDKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVVEGNHTVLLLEFNQDKDFFLDPKDALKG
LLETEKGQRRKVISPSTFAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNAEKTRKISVQMIEKYVPMVREALEEVQPYYKDQKEYEVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A328SD34|diphthine synthase|EC 2.1.1.98|Methanosphaera sp. SHI613|TrEMBL
MLYFVGLGLFSEDDISYKGFKALSNVDVIYAEFYTAKLMGGNIDNLIEKIDVPFIRLKRE
DVEDKNIVLEEAMTKDVAFVAAGDPLMATTHTELYVEAKNKGIETRIIHGSSIFSAAPGL
SGLQAYKFGKTTTVPFPDENFFPHSPYDAIKSNLEMGLHTLVLLDIQAHRDRYMTVNEAV
SYLSKVESDRQEGIFDDDTIVIGIAQAGSDKPIVKGGRVCDIIDYDFGSPLHCMIVPGNL
HFVEAEALITLADIPEELLEQFL
>K1UK38|diphthine synthase|EC 2.1.1.98|human gut metagenome|TrEMBL
MAKLYIVPTPIGNLDDITIRAVRVLSEV
>A0A2A5QXE8|diphthine synthase|EC 2.1.1.98|Natrinema ejinorense|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSKLIGTTIDDLESYHDIEIEVRDRA
GVEQHPEDMLEAAEREDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRVDGLHTVVYLDIKVEREEYMTA
DTGATLLAEEYPGLVGVVVARAGSPDPLVEAGTMTELADRDFGDPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A4U7EWT6|diphthine synthase|EC 2.1.1.98|Halorubrum sp. GN11_10-6_MGM|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVDDLEAHHGVDVEVRDRE
GVERDPEPILDAAESGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPTGPG
PDHEEYMTADVAADLLAEGWRDELAVVVARAGSPDALVTADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLADAPETLVGE
>A0A1V4THD6|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. PtaB.Bin024|TrEMBL
MLYLVGLGLYDEKDISINGLEAIQSADVVYAEFYTACLFGGDLKSLENLAGMKINILKRE
EVEEDNLPIKQAEDKDVAFLTAGDPLMATTHSDILMEARKKGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEANYFPHSPYHVINENRKMGLHTLVLLDIQAHRDYYMAANEGL
EYLLRVEDERKGGLISDDTLAVVIARAGSREPLVRAGPIRKLVDEDFGGPLHCIIIPADL
HFLEAEGLVILGGAPENILEDQ
>A0A8J8AB71|diphthine synthase|EC 2.1.1.98|Thermococcus sp. JdF3|TrEMBL
MAIYFIGLGLYDERDITLKGLETARKCDLVFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EEVELHFERIVLSEAKERDVAFLTAGDPMVATTHSDLRIRARELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTMLFLDIKAEQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMLKEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKDILDGI
>A0A849QKL0|diphthine synthase|EC 2.1.1.98|Methanosarcinaceae archaeon|TrEMBL
AIRQADRVYAEFYTSALMGTTIREMEALYGRKITVLNREDVEQQPEWLQRALTEKVVFLT
GGDAMVSTTHVDLRMRAHELGIKTTIIHGSSILSAVPGLTGLQNYRFGKSTTIPHPYTHK
DRTIISHTPYDTIRSHLDGGMHTMVFLDIDPEKGYMTINRGCELLMEVDSQQEETELKQR
LTVGVARAGSTSPVVVALPMLELADYDFGGPLHILVVPADLHFMEAEALVKLAGAPNEIL
DMAK
>A0A1F9YW08|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon RBG_13_57_23|TrEMBL
MALAEGRLVFVGLGLHDERSITLRGMDAIRQADVVFAESYTSILSEGSLSRLESATGKKI
QLLDRTAVEDGKTILDACKSSRVVLLVVGDPMMATTHVDLRLRAEMQSVSTEVVHGVSVL
TAVPGSLGLQHYKFGRTTSLPFPQEGYSPTSPYDTIAENLSRGLHTLVLLDIDAENSKYM
TANEGLHLLQDMERRTSKLIITEATLVCVVARAGSPEACVRAGRISGLVNMDFGPTPHSI
VIPGRLHFMEEEALRTLADHNAALSPEKE
>A0A1Q7LSN6|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_40CM_3_53_5|TrEMBL
MARVTFIGLGLDSEKGLSLEGLQEARRASSVFAEFYTNPMPNLNLQELESLLGKKVTILS
REQLEDENGREIILAAEKKDSVLLVPGDPLVSTTHVSVRLSLAERGINSRIIHAASIVTA
VCGATGLQNHKFGKSTTLPNSTLVPSSIIDTVLNNKDRGLHTLLLLDTDRSKGSPLTIGN
ALLLLGTVLSELDDWLVVGAARIGSPDEKVRTARGRELKAVAFGDTPHTIVIPSRLHFME
AEALKVFSGASDTDLEDYR
>A0A075GRE9|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote KM3_185_F09|TrEMBL
MREVTPGLWLVGIGPGDIDAMSLEAVEVASRCDHRFLEGYTALLPPAQEELLTERVGEWT
RLMRPDVENPDELLGLAETSAVALLVVGDPLQATTHVDLQLRARERGIPCEVVHGISITT
IVTGALGLQSYRFGRQVTLAYPYGDYLPTSPLELVLANREQNLHSLMLLDLDLSGMGEAE
QQPMSPADAIAVIRQTATKLGADIEGWTMVLCSDMGTTEQRLVCGTPEQISSVEGGRIHC
LVIPGSLDELEELALERWRA
>A0A7J2IDA9|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYLIGLGIYDERDITLRALEVLRDVESVYAEFYTSASNVNLKNLEELIGKRIHVLSRCD
LEEHPEGNVLKDSSKKKTALLVPGDPMVATTHVDIILRARKLGIKTKIVHGSSIYSAVAE
TGLQIYKFGRTTSIPFPERSYYPTSPYDVLRENLKTGLHTLFLLDIKPEENRFMSVNDAI
RILLRIEEKKKEGIFTEETRCLSAARLGGNSIIRYGRVRDLMDYDFGRPPHVLIVPGKLH
FMEEEMLKTFTHS
>A0A497S2V6|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYLIGLGIYDEGDISIKGVEILKRVDRIYAELYTSFFNGDLKTIENWVGKRINILDRED
LEGHPEDNILYNSSKKDVALLVCGDPLIATTHADILLRANKMGIKVKVIHSSSVYSAIAE
TGLHIYKFGKTTTLPFPEKKYFPTSPYNVIKENLRGGMHTLILLDIKYEEKRFMTINEGI
EILLKMEKIKRENVIDNETLIVGVARLGNDTTIKTGTLNDLIDFNFGGPPHSIIIPANLH
FTEEEMLNLFK
>A0A7V5IBG0|diphthine synthase|EC 2.1.1.98|bacterium|TrEMBL
MPLYFIGLGLGDERDITLRGLETVRSCDRVFLDGYTSLLRTDLGQLEDLYGKKVTIADRE
MIEENVSSLLEPARTGNVAFLVVGDVFGATTHHDLVLRARQLGVECRFIFNASILTAVGV
CGLQLYRFGETISLVFWTNAWRPTSWYEKLEANRRRGLHTLFLLDIRVHEPSEESLARGV
KVFEPPRFMTIADAAQQLLTLWRERAQLLGRETDETGAGAFAYDSDTLCIGLARVGQVDE
LMAVGTLKEFSRKDFGPPLHSLVMPGDLHAVEAEYLASLPRASSLQTLLV
>A0A523VQR8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFIGLGLFDENDISLRGLEEARSADSVFAELYTSLMIGLRIKNLELLIKDKIVLLT
RQNLEEQDGEQILTEAKKGKTVFLVPGDPMIATTHVDLRIRAERNGIRTRVIHGASITSA
AIALSGLQNYKFGRSVTVPFNGNCPVSETPYNVIKMNMRAGLHTLCFLDLKVEEDQYMHV
HTALQMLFSIEDAKHESVITDKTLVVGIARAGSKNPTVKAGLFNEVLEFKFGGPPHILIF
PGKLHFVEAEALVTLAHAPDIIGGWVK
>A0A419QJN1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLGLHYEKGISLAGLEKARKAEKVYVEFYTNPMPYLSMENLQKFLGKPIIILKRKDLEE
KAKEGILKDALKMDVALLVPGDPMVATTHVSLRIQAYKMGIKTEIVNGVSIYSAAPSIVG
LQIYKFGKTVTIPFPTLTYKPQTPYDVIKENFVRGLHTLVLLDVDYEKGKYMNVKDGLEY
LLEIEEKRKEKIVTFDRLVVGVAGVGSPNPIIKGDIVKKLLNYQFKMYPQTLIFPGKLHF
MEVEALKIFAQTPEEALKPYEE
>A0A7C4VR78|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MAINGMGMLALVGLGIGGIKSLTLEGIDILKKSDLVYLDTYTTLTSNDLIKKLSEHIGKK
IISANRARLEDELESLLEQAKAKNITVAVLGDPLFATTHQNFLIEARKRGIPYIVVHNSS
IISVLTTSCGLHPYKFGKVSTITRQSGTPATSIYFTLYDNLIRGLHSIFLLEFDTKDLEG
VWPSSAFTLLKDAENIYKLEAFTEDTFLIVACRVGTENQKYYVGCVKELEKIDFGEPPYT
IIIPSRLHFTEEEALCILFSVPKDKLVNNTEGLRRRTDYLVNKYVKKTNEILRLAKERIP
KDQIKYEDLFENVECYLEDAIRFLNLGEDQLAMLSVGYAEGLLDSLRLQKILDLKW
>A0A523SQ66|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFIGLGLCDEKDISLRGVEEIKEADAVFAELYTSLMPGLSVQKLEKLVGKKVSTVS
RQVLEEEEGELILQQAKKGKTVLLVPGDPLIATTHVDLRIRAEGQGIKTRVIHGASIISA
VIGLSGLQNYKYGRSVTIPFPENGFISETPYEVIGENRKMGLHTLCFLDIRADEKRYMTV
KDGLETLLTMEKRKRNQIITKETLVVGIARAGSKTPIVKAGYVENVLNYDFGSPPHILVF
PSKLHFMEAKALITLAGAPEEIRERVQ
>A0A537CG72|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTVAFIGLGLNDERGLTLEGLEEARHASSVFAEFYTNIMPGLDRKKLELLLGKRIVVLSR
VELEDEGGRRIVEAAARKKVAFLVPGDPMIATTHISIRLELAKRGISSRIIHGPSVMSAV
CGATGLQSYKFGKSVTLPQESGVPRSLLDTVQDNKRRGLHTLMLLDVRAERSKQLTIGEA
AAKLVVADPALEDWIGIGVARIGSEDQLVLSGKLGRLQREEFGNVPHSLVIPGRLHFMEV
ESLKAFCGANGEDLEALK
>A0A523BDU2|diphthine synthase|EC 2.1.1.98|Candidatus Verstraetearchaeota archaeon|TrEMBL
MGSLSFIGLGLFDERGMSLYGLELARSADIVLIETYTNIMPSLNIRSLEALIGKEVNXVD
RRYVEDGTNXLMTASEKNVALLVPGDPFIATTHIELRVRAERRGIPVMVAHAPSIISVAP
GVAGLQNYKFGRSATITFPDNYSEVPYDTISQNRRAGLHTLLFLDLRAEEGRYMSVPEGI
RLLMEMESRRGEGVVSPDMLVIGIARAGSPDQLVRGGRAKDLASLDXGQPPHSLIVPGRL
HFMEAEALEVLARVDRALLSQHVERA
>A0A843CG76|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MPYFTFIGLGLHDEKGLTLEGLEEAKKSDVTFAEFYTNLMPQLNLTRLESAIGKKIRVLD
RTQLEEHAGEELINAARDKRVSMLVPGDPMIATTHVSLRLELAKRGIKARIIHAASITSA
ICGATGLQSYKFGKSVTIPSDDPLPNSVLETLSENRVRGLHTLLLLDVRAGKGKQLSIDN
ALMKMMRANPDLANRLMVGAARVGASDEKVKAAKTRELTSEDFGAPPHSIVAVGRLHFME
AEALKVLCSASESDLRENS
>A0A842QT91|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MQKMQHPPNPRLQRNHQNQPATRTPRHHHMPHLRIHKTRPHRRKNMITLISIGLNSHKDL
NLNAIEAAREASKLYLEDYTMKLDTTREKLEETIGKTITPLKRNGMEEQAHQLLEEAKTS
KIAILVGGDALSATTHISLILDAHDLNIPTRVIHGSSIFTAITDTGLSIYKYGKTVTIPL
PEKGPATTVIRTINENYHHGLHTLFLLDLDKPKEKYLTIPDAINILTETGLPPETLLVGV
ARLGGPNPTIKADTAHKLTQIDFGSPPHAIIAPGRLHFLEEEALETLADCPREVIQNHNP
VGETDRLITKYTKSCRKVLEKHKKNRLPINTTRNQVNELLQHAENYLDDAEYYRTDKKPT
ALTCVAYSEGILDALKLLGILEFEW
>A0A8B2HVZ5|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp. K4|TrEMBL
MLWFIGLGISGSKSIPSEAMDVLAKADIVYLEQFTSPISKSDFIKIKKMTKGEFKPAKRW
LVEDGNEILQNAKKKKVVLLSYGDPYIATTHIELRTRAIEEKIKTFSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALAG
LIDTEKGQKRKVISESSYVIVASRIGFKDQAIISGKISSLKKKDFGKPPHTIIITGKLHF
TESDALKILGQCLDEPIDNSEKTKKISKQMMEKYVPMVREALEEIEPHYRGKKEYQVILE
NAELYIQDAEKFLEDGQEEVAILSIGYADGLVDALRLAKGLDPKM
>A0A534LQ05|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLDGEKGITLRGLDEARSADLVFAELYTSALPGVSLEAVEKLIDRKIRRLT
RQEVEDGQVLLAAAAKGAVAFLVPGDPMTATTHVDLRLRAAASKIRTRIVHGVSILTSAA
GALGLQAYKFGRATTIPFPAPGFAPTSPLEAILANRTAGLHTLVLLDLREDGTFLPPRDA
IASLLQMASALRTTQFGPHTLACVLSRVGSPEVRALAGPIGELADRDLGPPPHSLVIPGT
LHFLEKDALVAFAGAPHDL
>A0A831JUU6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MTGMGRLIFIGTGLMGGDWITTRGIEAAREVDFLFAEFYTSYIGDEGVKRLENILGRRIV
RLSRDEVEMKERLFKYLEDGDVGLLVGGDPMAATTHVELRLEAERRGHRTDVVYGVSIFS
AAPSSVGLQHYKFGRVVSVPWVSEKFMPRSVLEGIEGNLRCGLHTLLLLDLKDGEGFMSV
NECLRTLLKLEERHEMGVVNEETLVVGAARIGDPTECIKGGALSEMLEENFGPPLHVVVI
PGRLHFVEEEALRTIAGVRDDVLERWKNKIESFCPKGPTPS
>A0A368NCB2|diphthine synthase|EC 2.1.1.98|Haloplanus salinus|TrEMBL
MLSFVGLGLYDERSITVEGRQALRAADRAFAEFYTSRLVGTSVDALEAHHGVDIEVRDRT
GVEQRPDPILDAAEDESVVFLTAGDTMISTTHVDLRLRAIDRGIDTRVIHGVSAAQAASG
LTGLQNYRFGKAVTLPFPRAHGGDGVPASVVDSVAANRERGLHTLVYLDIKVDDGRGSEA
DETYMTADVAAGLLAEAWPDRLGVAVARAGSPAPVVAADRLSALADREFGDPLHLLVLPG
DLHHVEADALRTLGGVPADRLPE
>A0A7C7PGY6|diphthine synthase|EC 2.1.1.98|Marine Group III euryarchaeote|TrEMBL
MLTIIGLGLGGPNSITMDGVISLSLADHIFYETYTSPIHPETLEWVKLKSQKEPIHLSRG
QVEEPAELIDLAKEKNISFLIVGDALSATTHVSLLLECKKNNVEYQVIHNASVLTAVAGV
LGLQHYNFGPVATLVLP
>A0A6B0SSG6|diphthine synthase|EC 2.1.1.98|Halobaculum saliterrae|TrEMBL
MLTFIGLGLWDERSVTVEGREALRSADRVFAEFYTSRLAGTTVEELETHHGIDIEVRDRA
GVERDPEPILDAAADGEVAFCTAGDTMISTTHVDLRVRAAERGIDTRVIHGITAQSAASS
LTGLQNYRFGKAVTLPFEYAHGAEGTPQSVIDGIEANRERGLHTLVYLDIKVAGSSPAGP
AEGEADEFMTADHAAAALARDWDEDAVGVAVARAGSPEPVVAADTLAALAERDFGDPLHM
LVVPGELHHLEVEALAALAGCPRDALPAVE
>A0A497JH58|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
ALNAMKECSELYFDSYTSCFSEGSLAQLEKLAGRKIIPLQRAEIEEHFIEKLKGAREKSI
ALLVVGNALFATTHIQLLIDCAKQSIPYKFIPGISLTNYLGLTGLSNYRFGEIVSVVMPE
PNYAPESFYDKIVRNYENNLHTLCLIDIKNGKPVSVKDALQRLLEIEAKRNAKIIKNTLI
IVISSLAGEKQKIVAGRAEEILKKEFATPASIIICSKLSENEREALKTLYGVKQ
>A0A1V5B0W3|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaU1.Bin060|TrEMBL
MLVFIGLGLYDEKDISVKGLEQLLAADEIYAEFYTSRLMGSSHEKLESFFGRQIRLLSRE
DVEGDPIWLEEAREKVVAFLVGGDPMVSTTHLDLRLRALDMGIETKVIHSSSIVTAASGL
TGLQNYRFGRSATIPFPYVSRGRRIVSQTPYTVLKENLQRNLHTMLFLDIQNERFMTVNE
GASLLMEMQDESGEKLLLGRLGIGIARAGSEDSVVKADLLSRLALYDFGGPLHILIVPAS
LHFMEAKALVALAGAPPETLKGDE
>A0A833A2H5|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLKATIYFMLYLIGLGFDEKDITLKGIEAGKKCEKCYAELYTSDWKGDIKNIEKLIGKEI
KILERSDLEENLDIWINEIKDYNTALFVPGDPLVATTHIAIVDQALRKGIKVKIIHAPSI
ISAIASCGLQIYKFGKTATIPWSGQVENVAKTIEFNKQHGLHTLLLLDIGMSGEQGLKIL
LSKNIITEDTDIIVASNLGRENEKILFCKAKEIKNFPSPCVIIIPGKLHFAEKEFLELLR
CGNDRKRA
>A0A3R7A9B0|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MLTFVGLGLYDEKDITLKGLEAVREADVVYAEFYTSPLGGKTVEKMQEVYGKRISVLERR
DVEEKAEEGILKHAKHQKVVLLSGGDAMIATTHVDLRLRAIDMRIETRIIHAPSISSAVA
GLCGLQSYKFGKSATIAAPYGKKGIISAVPYDTLIANKERGLHTLLYLDIPMRINEALEL
LETAEEKRNLGGETLKKSIAVGIARAGSDKPVVRADYFGALKSYDFGELPHVLVVPGELH
FLEREALIKIAQAPERI
>I6V051|diphthine synthase|EC 2.1.1.98|Pyrococcus furiosus COM1|TrEMBL
MPLYFIGLGLYDEKDITLKGLEIAKRCDKVYAEFYTSLMAGTTLEKIEEVIGKKIIVLNR
EDVEMNFEKIVLPEAKEKEVAFLTAGDPMVATTHAELRIRAKRMGVESYVIHAPSIYSAV
AITGLHIYKFGKSATVAYPEGNWFPTSYYDVVKENLERGLHTLLFLDIKAEKGKYMTANE
AMELLLKVEEMRGENVFTPNTLVVVLGRAGSLNPTIRAGYVKDMIKEDFGKQPHVLIVPG
KLHVVEAEYLVEIAGAPKEILEQFAPRKM
>A0A366MCX5|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp. NOE|TrEMBL
MLYFVGLGLFDEKDISLKGLEVLKSVETVYAEFFTSRLFGSSFEAIEEIIEKKINVLNRQ
EVEEKNVFMKEAIEDKDIGLITGGDPLIATTHTDFLVEASKKGIDYEVIHGSSILSSAPG
ISGLQAYKFGKVTTIPFPDENFFPHSPYTVIANNLANDSHTLVLLDIQAHKDRYMTVNQG
LEYLMKVKDDLISSDKKEEAVIDEDTLTVGIARVGSKDVLIKADTIEKLIAFDFEGPLHC
IAIPSKLHIVEAEYLVEVCGAPKEILDGI
>A0A830FZE2|diphthine synthase|EC 2.1.1.98|Halarchaeum rubridurum|TrEMBL
MLTFVGLGLYDESSITVEGRDAIADADDGAVFAEFYTSHLVGADVADIEAYHGVEVDVRD
RAGVEQEPAPIFDAAESGDAVFLTAGDTMISTTHVDLRLRAHERGIETRVIHAPTAESAA
SSLTGLQNYRFGKATTLPFEWAHGADVVPGSVTETIEDNRARGLHTLCYLDIKVGRGPEG
ADPDFEEYMSADYAAGLLAEAWDPDALGVVVARAGSPDPTVRADRLAALADADFGDPLHM
LIVPGDLHHVEAEALRGLAGAPADLTTAE
>A0A523B5W8|diphthine synthase|EC 2.1.1.98|Candidatus Nezhaarchaeota archaeon WYZ-LMO8|TrEMBL
MLRCASLSLIFIGIGLTAKGLTIEGLSEAQKAEHVFIDAYTNLIPRNELHTLQNLIGKDI
KPLYRSDVEGRGVYELLKLTEKSTVALLVVGDPFIATTHIALRLEAIKRGVKVKYVPSAS
IASVIPGLTGLSSYKFGKSATIVFPDKGSNNAAYDAIKDNSSRGLHTLLYLDLEVENKRA
MTINEALKLLLDVEAQRAEGVVREDMLIVGIARACWNNEIVKAAKLSKLINYDFGPPPHV
LVVPGSLHFMEYEALKALAGMED
>A0A484F7E5|diphthine synthase|EC 2.1.1.98|Methanimicrococcus blatticola|TrEMBL
MLIVVNSNKLYLNLFHSLFKFFLQMVKYHPFNEADMLTFIGLGLFDEQDISLKGLEAVQS
ADLVYLEFYTSYLMGTTIEKMEELYGKPIIRLMREDVEQNPDWLENAKTQNIVFLTGGDT
MASTTHVDLRIRAKDMGIDTRMIHGASITSAVFGLSGLQNYRFGKSVSIPFPYVSSRGNR
VVTETPYDTIKFNQENGLHTLVFLDINSEHGYMTVQQGLALLLEVEEKRQEGVMKNRIAV
GIARAGSADVCVKANYANNADAFELGGPLQILIIPGNLHFIEAEALVKLAGAPARLLQEF
SNES
>A0A7J3B975|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLYLIGTGISLDLTLEGLTVLKQCEEVYLESYTNPLLKEKINEIERMINKKINVIERKEV
ESDFLIKKAKKKNVALLSSGDPLTATTHVALLLDGRKEKIEVKVIHNSSIYTAAPGKAGL
QIYRFGRTATLVNPQPNYKPTSSLDVIRANISMNMHTLVLLDTEPQPMEAKTALQMLSEF
KEAVVLSRLGEKDERIIYGRIEDLRKEDLGKPPFSIIIPAKLHPIEEEYLKAFSFKK
>A0A497IGX7|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLFLIGLGLSDEKDITLRGLELASSADLVFLEAYTSKLYKEDLKALEKLIGKKIQRADRE
FIESSKILLYAHKHNVALLVPGDPMIATTHAELILRAREEKIETKIVHNAGIMNAVLDTG
LQFYKFGRTTTISFWEGNYKPTSFYDVIKRNKKMNLHSLCLLDIDIVKNRYMSPNEAIRR
LLFIQKQRGDEAVIDEVVVCSRMGSTKQNIIYGKAVELQNLAFGNGLHCLVIPAALHDLE
REFLEQFRVKQ
>A0A833DZI9|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDERDMTLKTLEYARKADKVYAEFYTAALTGTTLDRIEGVIGRKIIPLTRE
DVEYRGYKLVEESRDKLVVLLTVGDPMVATTHIDLVIEAKKRGVDVRVINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYNVIRDNLKMGLHTLCLLDIQSDKNRFMSANEGL
KILLELENRRKENVLNEDSKVVVLARAGSLKPKIVYGKIRDLIDYDFGPPLHSIIIPGKL
HFMEEEALKYICEHVP
>A0A662FYV4|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLVIAGLGLYGFRDVSYGLMEWIRKADVIFLEQYTSILPGFDVKEFSKWIGKRVVLTTRK
DIEEMNGGGILHEAKKGIVVFLTIGNPFYATTHVALVLRAAQMGIDYLVIPSVSVFDGII
CSLGLQMYKFGKTATLTFPSEEYGFYPHSTYFTVLDNLRKGLHTLLLLDLKVEENVFMTV
DKAVDVMLLLERLNNKNVFDEETLMIGVARATALDEKVYIGKIGDAREVDLGPPPHSIVI
PGILHDVEIEYLSARFGVDKKVLEEWSNRVKTEYLDTQNT
>A0A662J2M0|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGLHDPLDLSVKGVETAKRCDKVYVEHYTSLMPGFTIKDLEKLLKRKVEVLTREDLEGEK
GKKLVEEAKVKDVALLTPGDPFIATTHVTLRLAAKKAGVEARVIHSSSIATAAPGLVGLS
FYKFGKTATVVYPEPGYYPETPYDVLKENLRRGLHTLLVLDLKVERGLYMSIPEALQILL
SIEERRLEKVLDLNTLVVGIARAGSLSPTVKAESIERLMKISFGPPPHSLIFPGRLHFIE
EEALIELCEAPRDVIEKHKAKFTAP
>A0A7J2RVL9|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLIGLGLNEKGISLDGLEAVKKCEKVYLESYTAEIPYSKEDLEKIIDKKINPADRNFV
ESLRILGEAKNTDISLLVYGSPLTATTHISLIQEAKKSGVKFEVIHAASILDAAAETGLQ
LYKFGKI
>L9WW91|diphthine synthase|EC 2.1.1.98|Natronococcus amylolyticus DSM 10524|TrEMBL
MLTFIGLGLYDERSITVEGRRALREADRVYAEFYTSKLLGTTVEELESAHDVSIEVRDRA
GVEQDPEEMLAAAEDEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPSSVTGTIDANRADGHHTVVYLDIKAERGEYMTA
DVGAELLAEVYPDLVGVVVARAGSPDPLVAAGTMTELAQRSFGDPLHLLVVPGDCHLLEA
DALVELAGADRSTLEIV
>A0A482YAA2|diphthine synthase|EC 2.1.1.98|Haloterrigena hispanica|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSQLIGTTIDDLESSHDLEIDVRDRA
GVEQHPEDMLEAAEDEDIAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIDKNRADGLHTVVYLDIKAEREEYMTA
DVGAELLAEEYPDLVGVVVARAGSPEPLVEAGTMTELADREFGDPLHLLVIPGECHLLEA
DALIELAGADRETLDIV
>I3RDN0|diphthine synthase|EC 2.1.1.98|Pyrococcus sp. ST04|TrEMBL
MVLYFIGLGLYDEKDITLKGLEIARRCEKVYAEFYTSLLAGTTLKKIEELIKKEITVLSR
EDVELNFERIVLPEAKEKDVAFLTAGDPMVATTHAELRIRAKKMGVKSYVIHAPSIYSAI
AITGLHIYKFGKSATVAYPEGNWFPTSYYDVIKENKERGLHTLLFLDIKAEKGKYMTANE
AMELLLKVEEMKGEGVFTPNTLVVVLARAGSLEPTIRAGYVRDLIEEDFGRQPHVLVVPG
RLHIVEAEYLVEIAGAPQEILKLAR
>A0A8J7Y9H9|diphthine synthase|EC 2.1.1.98|Halomicroarcula limicola|TrEMBL
MLTFVGLGLYDERSVTIAGRDAIREADRVFAEFYTSRLVGTDLESLEAFHETAIEVRDRA
GIERDPEPILDAAEREDVAFLTAGDTMVSTTHTDLRLRAEERGVETRVVHGTTAQTAAAS
LTGLQNYRFGKATTLPFERAHGGDGVPDSVVRTIEDNRSRDLHTLVYLDIKVDDPHWDDG
DDTYMTADHAATLLAEEFPETLAVVVARAGSPDPVVAAGTLSELADSSFGDPLHLLVIPA
ELHPIEEETLDAIADA
>A0A1N6X5U7|diphthine synthase|EC 2.1.1.98|Haladaptatus litoreus|TrEMBL
MLTFIGLGLYDERSITVEGRDAIADADDLFAEFYTSKLIGADVADLEAFHEKEISVRDRA
GVEQDPEEILSAAESGHSVFLTAGDTMISTTHVDLRLRAEDRGIDTRVIHAPTAESAASG
LTGLQNYRFGKATTLPFDYAHGADGLPASVTNVLDDNRERGLHTLVYLDIKVGWNPSGKG
DADAEDEYMTADVAAEMLADGYDDVLAVVVARAGSPDPLVEADRLSELAKRDFGDPLHLL
VVPGDLHHIEADALESLAGAPSDLLTVE
>A0A843J386|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MTSELVFVGLGLSGTDGMTVKALNALRECDIIYAEFYTSTLIGTSPQDLEKVIGKKIKVL
YRSQVEECDDIIRDAMSSRVAFVTAGDTMLATTHVDLRIQAAEAGIPVRVLHGVSIFSGC
PTSLGLQPYKFGRTVTLPFLEPNYHPKSPYDHIMENKARGLHTMILLDIRADELRYMTAH
QAIEWLLEGEKKWGEGLIGEKTLLCVASKVGSPEERVFAGYPQDLLSKDLGEPLQTLVLP
GNLHFMEAFALVRFAGAPEEIIEDER
>A0A1I6GBK1|diphthine synthase|EC 2.1.1.98|Halorubrum sodomense|TrEMBL
MLTFIGLGLYDERSVTVEGRAALREADRVFAEFYTSRLVGADVSALEAHHGVDIEVRDRA
GVERDPEPIFEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDGVPASVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLAEEWGDALGVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVGE
>A0A662LJK7|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSGELVFVGLGLGKGDLTLKALDVLRKSDVIFCEMYTSKPSDYCLDDLRGLVRKEIHILD
RKELEEGHAIIERAKEERVALLVVGDPMAATTHVSLRIEAEKKGIKTRIINGISVLTAVP
SILGLQHYKFGRTTTLVYPENSYYPLSPYYTIKENLERGLHTLVLLDINMEKGRLMTIRD
AIDLLFDMENRAGDGIIREDTLMCGVARAGSDDCIARSAPAKVLRGIYFGDTPHTLVIPG
NLHFMEEEALELFSGYRKLR
>A0A662JY31|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSSGELVFVGLGLYDEEDISVKGLSLIRGCDRVFAEFYTSQLVGTNIGRIERLIGKPIEV
LSRDEAERGDRVLKSALKDKTVFLTCGDPMIATTHVDLRLRAVEKGIRTRIVHGSSIVTA
VPGLLGLQSYKFGRATSLVFPDKNYSPISPYYVVKNNREMGLHTLVFLDIHAEKKRYMTA
NEGMDILLDMERNVGDGVFDEDSVVCVVARAGSSDPLLRADRICVLREQDFGHPLHTIVV
PGRLHFMEAEALVRLAGLPKELAGKLQKL
>A0A497HFY7|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGELIFVGLGLWSEKDITIAGKEAAGTCDKVFAEFYTSMLGVPEEKIEEVIGRPIEVLSR
EEVEDGNAILDEAADKKVCLLTGGDPMTATTHIDLRLRAIERGIDTKVVHGISIMTASAG
LLGLQSYKFGRTTTLAFPEGDYFPTSPYGVIKENMERGLHTLVLLDIGKKLMTANEGIEL
LMEMEERERGGVIGKKTLMAVVARASSPSPVAKAGYAHELVKENFGPPLHCIVVPGKLHF
MEAKALVMLADAPEEIMK
>A0A498GYL3|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. MSH10X1|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYVEFYTSCLMGTTLEKMEKLYGKKVILLSRE
DVEQNPVWLNYAGDRKLCFLTGGDTMISTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTKVISETPYDIIKQNSELGLHTLVFLDIDKEKGYMTV
NTALELLLGVEEKRGEGIMRGAAAVGIARAGSESPVVKADYAENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAGGPIGFMKDVE
>A0A6A9SL41|diphthine synthase|EC 2.1.1.98|Halobacterium sp. CBA1126|TrEMBL
MLTFVGLGLYDERSVTVAGADAIADADRAFAEFYTSRLVGADVADLEAYHGTEIVVRDRA
GVEQDPEPILAAAESGDAVFLTAGDTMISTTHVDLRLRAAERGIETRVVHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADGVPSSVIETVEANRERGLHTLCYLDIKVDHPRVDG
>A0A7J4N442|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MASDEVPAGLWLIGIGPGDLEHMTERARSVARRCKKRYLEGYTAVLPTEQEALLESVVGP
WERMMRPSVESPETLLAESRNDSVALLVVGDPMQATTHIDLEARCMEEGIGFEVVPGMSA
TSLAVSLSGLQSYKFGRQVTLPYPYGDYLATSPLEMILRNLESGLHTLVLLDLDPTGMGV
DLPTPMSPSQAISTLEEMSSKWLEEGDGLDSTSVVVNEWEGMLLSDVGTKGQRVFSGSLE
EISKIQYGWVHSLIIPSEMSDNEREAFSRRGAM
>A0A0W1S295|diphthine synthase|EC 2.1.1.98|Haloferax profundi|TrEMBL
MLTFIGLGLFDERSITVEGREALADADRAFAEFYTSHLVGATVEDLESYHDIDIDVRDRA
GVEQDPGAILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEERGIETRVVHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRERGLHTLVYLDIKVDWEGRRGV
EVEGDEYMTAEYAAELFAEHWDPDALGVAVCRAGSPNPVVAADRLSELANRDFGDPLHML
IIPGEVHHVEADALMGLGGAPTDLFDHDER
>A0A0F8DK11|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 2.H.T.1A.15|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRRESVMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVNLAAGPEEIMEEME
>A0A370LIB9|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon|TrEMBL
MLWFIGIGVSGLNSLSNETLDVLKKSDIVYLEAFTSPISKVELSKFKKKIKGEFKIAKRW
MVEDGKEILKNAKRKKVSLISYGDPYIATTHIELRTRAINEKIKTYSIHAASSITSMVGE
CGLHYYKVGRIATIMSEEKSLTTPYYVTYKNLIEGNHTILLLEYNQDKDFFLKPNDALHD
LIETEAEQIRKVISKSTFVIVASRIGFKTQKIICGSINKIQNVDFGKPPHTIIIPGNLHF
TESDALKVLVKCLDEPVSNSEKIKKIPTQMLEKYVPMVRDAIKEIAPHYKDSKEYCEILE
NAELYVQDAEKFLEQGKDDVAILSIGYADGLVDALRIAKGMDPKM
>A0A662RBU2|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGVRAIKDADMVFAEFYTSKMMGTTIERMESRYQTEITTLSRD
EIETDPAWLHHAIDRDVVMLSGGDPMVSTTHIDLRLRASDLGIETAIVHGPSIASAAAGL
AGLQNYRFGKSATIPFPYTIRSKTVVSETPYNTVLLNRDNDLHTMLFLDIDHEKGFMTIS
EAAGLLMQVDERGLLDHTLGIGIARAGSPDVVVKCNYLRDLAGSEFGAPMHLLIVPAGLH
QMEAEALVRFAGAPEGIIER
>A0A7C4D4T0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MIFIGLGLYGCFDISLRGLEEIKRADYVFAEFYTSFMPSFNLEEFRKLSGKDLIVVSRRH
IEDEDGTIILERAKYGRAVLLVPGDPLIATTHIFLRIKAEKMGIKTRVIHGPSILSAAIG
LSGLQNYRFGKSVTIPFPDDNRLSYTPYIVIAENKIRNLHTLCFLDIKAEEGKYMSVNEA
LKILLRLEEERKEGIIKREKLAVGIARAGSDDAIIKADAIEELIDFSFGGPPHILIIPSE
RLHFMEAEALITLANAPRWIMRMVG
>A0A7C4W840|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEIVFVGLGLHDEMDVSLKGLEEVKTADAVFIECYTSILPGFSLRRFEKLSGRTLRIVS
RRELEEENGEAILKVAEKGKAVLLVPGDPFVATTHIALRIEANRRGIKTRIIHGASIISA
VVGLCGLQNYKFGRSVTIPFPENYSETPYEVIAKNRKLGLHTLCFLDIDAEAERYLIIRD
ALKMLLETEEKRRMDAVTRESLAVGIARAGSPDPIVKADYVGELIFYDFGKPPHTLVITG
KLHFMEAEALIAFAKAPISVRRMIE
>A0A090JTS8|diphthine synthase|EC 2.1.1.98|Methanobacterium formicicum|TrEMBL
MLKVKKMLYLVGLGLYDEKDISINGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTI
NILRREEVEEENLPLKQAKTKDVVFLTAGDPLMATTHADILMEARKNGIPTRVIHASSIL
SAAPGIAGLQAYKFGKVTTIPRPENNYFPHSPYQVIAENRKMGLHTLVLLDIQAHRDYYM
TANEGLEYLLRVENERNEGIITTDTLAVVIARAGSPEPLVRAHRVDVLVEEDFGGPLHCM
IIPGDLHFLEAEGLVILGGAPEHILQE
>A0A8D4V6X6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter arboriphilus|TrEMBL
MLYFVGLGLFDEKDISIKGLKALKSVEIVYAEFFTSHLFGSSFKAIEELIGKEIKVLNRH
EVEEENVFMKEAIKGRDVALITGGDPLIATTHTDFLVEAKKKGIETEVIHGSSILSSAPG
ISGLQAYKFGKVTTIPFPDENFFPQSPYMAIANNLVNDAHTLVLLDIQAHNDRYMTVNQG
LEYLMKVKDDLISNGKYNEAIIDEDTLAIGIARVGSKDVVVRADKIGELIDFDFGGPLHC
IAIPSKLHIVEAEYLVEVCGAPREILDEI
>A0A133V0M5|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA261C02|TrEMBL
MLIFIGLGLQEKGLTLEGLEEAQNADRTYAELYTSLIPDLDLDALSEKIGKKIKVLERED
VEEHPDEILETAKSEKVAFLVPGDPMVATTHVDLRLRAEKAGIETRIIHGASIEIAAPGL
AGLQSYKFGRSATIPLPEKPSETPYEVLVQNQEDGLHTLLLLDIEAPEERYLTASEAMEI
MLDLESKGGKNVFTQETLVAVIARAGSEKPTVKAGKVGDLIDFDFGSPPHVLIVPGKLHF
LEAEALQVFGGAPEEVEGYVE
>A0A662R816|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFIGLGLYDEKDVSLRGLEAIRSADRIYLECYTSLFTGTNIKQLEKLYGKKIHLLERE
DVETNNWWLKDAVDQNIVFLTGGDAMVSTTHIDLRLRAKKLGIGTQIIHGASIISAVCGL
SGLQNYRFGKSATIPHPYTRKEKIIRSHTPYDTIELNRKNNLHTLIFLDIDKNIGCMSIN
QGIELLLQVEEETGGDAISNCIGVGIARAGSFAPVVKADYLENLKHIDFGDPLHILCIPA
NLHFIEAEALIAFADAPGSILNQSNSFKEFSFYEGNRAQEKNEKV
>D3DZ64|diphthine synthase|EC 2.1.1.98|Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)|TrEMBL
MLIVYCLNFYMVFFMFYLVGLGLFDEKDISLKGIETLKKVDKVYAEFFTSRLFGSNFESI
EETIGKEIIVLDRTQVEEESVFLKEAKEIDVALITGGDPLIATTHSDFLVECARDGTDFE
VIHGSSILSSAPAISGLQAYKFGKVTTIPFPDLEYNYFPKSPYMAIEENLKNDMHTLVLL
DIQAHKDKYMTINEGLENLMTIKDNLEREGMIDENSLAIGIARVGSKDNVVKAGYIKDLL
DYDFGGPLHCIVIPSKLHIVEAEYLVHVADGPKEILDDL
>A0A7L4QWX5|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
THVDLRLRALAMGIETTLVHGASIASAICGLSGLQNYRFGKAATVPHPYVTSRGSRVVSE
TPYDTIKMNMENGLHTAVFLDIDKDKGYMTVNEALEILLEVEGKRGEGVMADRIAVGIAR
AGSPAPVVKADYAQSLKSFDFGEPLHILIVPASLHFVEAEALVKLAGAPESITEYLE
>A0A662Q1D5|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLGFVGLGLYDCRDLTLRGLEILRKADKVYLDTYTSIVPNFSVEELENLIGRKVVSVDRS
VLEGRGLFEILEEAREKDVVLLVPGDPFIATTHISIRLEAEKRGVKTEVVHAPSVVSSAI
SATGLQIYRFGKVVTLVYPDPEVGFYPISSYEVLEDNFNRKLHTFFLLDLKEDRKMTIAD
AVDVLFLLEEKVGSGIISSETLGVGVARVGSPDSVLKAGTLEFLKRYDFGPPPHSLIIPS
SLHPVEAEALILLCNADREMIEKWTKKIK
>A0A842NTE2|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGLGISGTQSIPIEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKRAKNSTVVLLSYGDPYIATTHIELRTRAKLEKIETKTIHSASAITSMIGE
AGLQFYKIGRMMTIMNEKKSTMTPYSTIFKNLTEGLHSVILLEYNQDKNYFLDPKNAISN
LLDIEREYKKDVLTNDTFAIVASRIGFETQKIISGKFSNLLKIDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSSKIKNISVQMIEKYVPMVRKALEEIRPLYNDSKEFQEVFE
NAELYINDAENFLKQGKNETAILSIGYADGLVDALRIAKGIDPKM
>A0A533VM37|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFIGLGISGIDGISSNTLKIIKKADVIFLENFTSPIGKQEVSKIEKLVRRKFKIAPRW
MVEDGKTILLEAKRKTVVLLSYGDPYVATTHIELRTRAETEKIGTRTIHGASAITSLVGE
CGLHHYKIGRPVTIMREISSLTTVYYTIYENLIRDSHSILILEYNSDTNFFLGPKEAFSN
LLLTEGSQKRNVINESIFAMVASRIGTKNQSIIAGKLSSLMDADFGKPPHTIIIPGKLHF
TEDDAIKTLAKCLDDPSDNSSKIQKISQQMLLKYLPKARKALEEVQRQFKDNKDVQPIIE
NAHLYLDDAEKFQKEGKDELAVLSVGYAEGLIDALRLSKGIDPWAQSL
>M0N230|diphthine synthase|EC 2.1.1.98|Halococcus thailandensis JCM 13552|TrEMBL
MLTFVGLGLYDEHSITVEGREALRSADRVFAEFYTSRLVGTTIEELEDHHGVSIEVRDRA
GVEQEPAPILDSAETGSTVFLVAGDPMVSTTHTDLRLRAHEHDIETRIIHGTTAQTAAGS
LTGLQNYRFGKATTIPFAYRDRPIPESVVETIEDNRERGLHTLCYLDIKAAEGRYMSADV
AAGRLAPELDGLGVVVARAGSPDPLVVADRLSALAEGAFGDPLHLLVLPGELHHLEREAL
EALADAPPELL
>A0A3M7QWC6|diphthine synthase|EC 2.1.1.98|Brachionus plicatilis|TrEMBL
MLYIIGLGLGDVEDITLKGLKAVKSSDLVYLEHYTSILGGGAEYKNELENFYGKQIILAD
RTMVEQKSDEIIDAAKDKTVSFLVVGDPFGATTHTDLVLRAVEKSISYEVIHNASIMNAI
GCCGLQLYNYGEAVSICFWSEAENWRPKSYFEKIGENRARGLHTLCLLDIKVKEKSLINI
IKNRDIYEPPRYMSVSQACSQMIDIIREAGKYESIDGDENQTELDIKKLVESKVITEDTL
AVGLARVGRGDQALRVDTVTNLSDCDLGEPLHSLVIAGKLHPLEVDFLRLFYNGDNFDNL
FYQVLSKNLDMAKDYSKEGKFIDLPGAEKGKVVVRFPPEASGYLHIGHAKAALLNQFYQN
EFEGKLIFRFDDTNPAKENAEFEQVIEEDVKLLGVKWDRFSRTSDHFEYLLNLCEKMLRE
GKAYADDTDPEEMKKEREAKIESKNRGNSIEKNLEMWEEMKKGSEQGLKCCIRAKIDMNA
ANGTLRDPTMYRCKPETHLSTGDKYKVYPTYDFACPVVDSLEEVTHALRTTEYHDRDEQY
MWFLEALNLRKPYIYEYSRFNLQNTVLSKRKLTWFVESGKVKGWDDPRFPTVRGILRRGM
TVEALKQFIVAQGSSRSVVQMDWDKIWAINKKFIDEISPRHTAVLKGKTVLVNISGQSSV
ESKQVPKHPKNEKLGTKTVWYSDKVFIDEADADTLKENEVATFMDWGNVKIDKINRDNSG
KITNIDAELNLENKDYKKTLKITWLANVADKAPFTPIKCYHFDHIIVKPVLDKDEDFKQY
CNHQTEFEFNSLGDNEMRNLKKGDIIQISRRGYFIVDKAFDGESLVLFNIPEGNKRESPT
SYMSITNQKYASVQFAEEAEKKPKSDPKENKTQSASFAFTPEAEDLDKKIRKQGDTVREL
KTNKASKEDCDAQVKILLDLKTQFKKLTLNDWKPDLVAANKNQSGTKTETKKAESLDNPK
INEINAKIKETGDQVRNLKTAKASKDEIDATVKVLLALKEEYKTLTGQEWKPETGSTARA
PKAEKVKPKKEEKPVVKEESGKKQTRLGLEAKKEENLPEWYSQIITKGELIEYYDVSGCY
ILRPWSYFIWEQIKEFFDTEIKKLGVQNCYFPIFVSKAALEREKDHIADFAPEVAWVTKS
GQSDLAEPIAIRPTSETVMYPAYSRWIQSYRDLPLKLNQWNNVVRWEFKHPQPFLRTREF
LWQEGHTAFANYEEAAEEVHKILDLYSDIYGKLLAVPVIKGRKTEKEKFAGADWTTTIEA
FISASGRGIQAATSHHLGQNFSKMFGIEFEDPETNQKKFVYQNSWGITTRTIGILTMVHG
DNIGLVLPPKVSCYQVVIVPCGITVSLSKEDEKNLLDKCKVYEQEFRKAGIRVYGDYRDN
YSPGWKFNHWELKGVPLRIELGPKDVAQNKFVAVRRDTMKKEILEEANAAQTILNLLDDI
QESLYKKAEKNLKEHVVVVETWDDFMKNLDQKKIIMAPFCGDKEWEEKIKEEKMLLLKKE
HQLWELNRYVFHLISPSRLLTKMERKLNIILCSADLIKKKFILNIQNLQIKTKTKALSYN
SSCCVTLLIGPISINGFLFSRSNQSMRFLNHLFKKIFLNRKIKQSIILAKKDIKSPKRCS
FSIIKLKINNSLLFFEQQMIKCTQIRIFKSILRSIVQKLLLLILINIHKTTSRIIMP
>A0A7J2V0I2|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MLSVKKGHLYIVGLGLSPSMVSMLAIEALRSCDHVFYEEYTSIPSEGSIKDIEILAGKGF
EKLSRRDLEDLSAIEIFTRLDNGEKVCLASWGDPLTATTHIYIASEAVRKGHSYTYIPGI
SIATAALGFSGLMIYRFGRVMTMVRPRSSEEAGEIYGKIRKTLDQGMHVLLLLEMDVEKG
YYMKIHEACETLLKISKDLGDKDLEDRKALGLAGLGSRSQKICYASIKDLSKIVIDKLPQ
SILILGQLYFTEQEYIENMVRRYGACWSLLSSEA
>A0A7J4GPV6|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MVENMAATGLHLVGTGAGSPLNMTVGGKEIASSCDYRFLEGYTSLLGENGENRLEKLVGA
YEIIRRPEVENPERILELAKSNSVALLVVGDPMQATTHVDLLLRCKDEGIHTSVHHAVSA
VDLVCAGLGLQSYRFGRQVSLTFPHGNHLPTSPLEFIAENRFLGLHTLVLLDLDPTGMGI
EQPQPMTPPQAFEVMCRMVERLKDDPPPHLELENVSSARDLSRLKAVKWLLNEKIGDVHA
VICSNLGSSNAQIKSGLLSKITENCVSGIHSIVITGELIGMEKDALEKLH
>A0A3A5V0I3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTAVNRVDLPKTGLMLVGMGPGKINSMTIEAKNAAKSADFRRYEAYTALWPKGELAKLEE
EIGDIEMVMRPEVESPTELFELAKNHLVALLIVGDPLQATTHVDIQLQAIDAGINCMVFH
GISITTLVTGAVGLSNYRFGRQTTITYPYGGWVATSPLEVIAANIFQNQHTLALLDLDPT
GAGTGKQIPMQPKDAYESLGLMKEKLSSTISDMPEDNAVDSLKKLALKSFVNTDLDSIKV
VICADMGTKDEQITYSTVENLKNIAGGRLNSLIFPAITSEVEEKALLRWQ
>A0A822XC60|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MKAGLRLIGIGPGDLGLMTVNAIEAAKESDHRFLEGYTATLPPEQEGVLEDLIGSWTRLM
RPDVEKPDELLRLARSSTVALLVVGDPMQATTHVDLLLRAKDAGLDTEMIPGISATTMAI
TMSGLQSYRFGRQVTLPFPYGDYLPVSPLRYILDNRSRNLHTLVLLDLDPTGLGVESPVH
MSPAEAGGILLKMVEKYEIEGGSKEDLVEGILDWPVIVLSDLGMVDCRVCSTNLRNVSDV
KGGRIHCLILPSSMDDLEQSSFDGMYIGD
>A0A3A5VHK2|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MRLATPKSRRGLRMAANDTGPVGNQNGLVLVGLGLGTVEGMTLAAIEAAATADHRRYEAY
TALWSEAQLLRLEDKIGPIERVMRPQVEQPDELLALAATSRVALLVVGDPLQATTHVDLQ
LRAAEVGVPCEVVHGLSITTLVTGAIGLSNYKFGRQTTLTYPYGGWVATSPLEVIVANWS
QGLHTLALLDLDPTGLGTGNQQPMRPADAAKAMHMMRDKLEEHLQGESALDEENSWLNHM
VEAQGRYLAEPFEAWPVVLCADMGTPDQRVVATTLGALGQEKGGRLNCLVFPARTGEVEE
SALARWR
>A0A6V8EUG4|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MKAGLRLIGIGPGDLGLMTVDAIAAAKESDHRFLEGYTATLPPEQEGLLESRIGPWTRLM
RPDIEMPDELLQLARSSVVALLVVGDPMQATTHVDLLLRAKDAGLETEMVPGISATTLAI
TLSGLQSYRFGRQVTLPFPYGDYLPVSPLKYVLDNKSRNLHTLVLLDLDPTGLGVESPVH
MSPAEAGGVFLKMAKKYGMEDDSKIGTFEDMPDWPVIVLSDLGTKESRVCSINLRDISNV
KGGRIHCLILPSSMDDLEQSSFDGMYVGD
>A0A2G1WK05|diphthine synthase|EC 2.1.1.98|Halorubrum persicum|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSKLVGAGVEELEAYHDAEIEVRSRE
GVEQDPEAILSAADDGHAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVDTIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMAADVAAGLLADGWEDALAVVVARAGSPDSVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALAGLAGAPADLVEE
>A0A7J2GYN9|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGMGVHDPKDMSVKGLEIAKRCEEVFYERYTSPVSVEGLRELLGKEVKELGREDVE
ESNLLIEKAREKDVAFLVPGDPLVATTHQELVLRARKKGVRVRVIHSSSIVSAVCETGLH
IYKFGRVTSIPKTREDFFPTSPYHVLRENLERGLHTLFLIDPEISLEEAVEYLFEAERRE
GKGAISEETKGVFLSLGEEPEIVYGKLRDLKGRGKPQSLIIPGELHFMEEEFLRWWEHGK
EEKG
>A0A497SJF4|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
ALYMIGIGLNDEKDITVKGLDIVKKCSKVYLESYTSKLNCSIEDLEKFYEKKVIPVDREF
VENHTDELLTNEEDIALLIIGDVFSATTHYAVFMRAKELGIKVHIIHNASVLTAVGITGL
SLYKFGKTASIPFENENIESPYDVLKENKNLHTLFLLDLNPKQNKFMPASEAIDYLMRIE
EKRKENVFTKEKLCIVCAQLGSDSPVIRAGSAEELLNLKIDKFPQCLIVPGDLNFIEEEF
IQQWKK
>A0A7C5U7I5|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
DVEEEGHKILELASHKKIMIFVPGDPLVATTHSSIILECMKSGIEFKVIHNSSIVSAICE
TGLHIYKFGQIVTIPLRERIIEANSVINAIVENKRRGLHTLCLLDVDTESNKYVEVKEAV
RFLLENRVIDEDEKLVVGCCLGSVQKRILWKKASEVLLLNLPLPAIIVIPGNLHFSEREM
LEKL
>A0A8A2VHB2|diphthine synthase|EC 2.1.1.98|Haloterrigena sp. KZCA68|TrEMBL
MLTFIGLGLYDERSITVEGREALRTADRAYAEFYTSELLGASVADLEEAHDTNIEVRDRA
GVEQHPDDILSAAETEDVAFLTAGDTMISTTHVDLRLRAHDREIETRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTNTIDANREDGLHTVVYLDIKVGHERAAED
EYMTADVGAELLAETYPDLVGVVVARAGSPGPLVEAGTMSELAEREFGDPLHLLVVPGEC
HLLEADALVELADADRDALDVV
>M0JJ09|diphthine synthase|EC 2.1.1.98|Haloarcula vallismortis ATCC 29715|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIQDADRVFAEFYTSRLVGTDLETLEASLGTTIEVRDRA
GIEQNPEPILAAAESEDVVFCTAGDTMVSTTHTDLRLRAEDRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRARDLHTLVYLDIKVDDPHWDES
DDTYMTASHAAELLSKPFPDTLGVVVARAGSPDPLVVADTLDDLAEQTFGEPLHLLVIPG
SLHPLEADVLESTAGADLE
>A0A8J7T5Z9|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeota archaeon|TrEMBL
MMLYLIGLGLFDEKDVSVRGIETIKKCDSVYLERYTSPWRGNLGNLEKATGKRIKEVARS
DLEEKSKRILEEAIKKDVAVLVPGDPLVATTHSALALEAKKIAMEVSVVHSSSVFSAVAE
TGLHIYKFGRTATVAYPEEKFFPKTPYTVLGENKKNKSHTLLLLDVKAEDNKFMTINEAV
EILLEIEARENENVFDNETFCVGIARLGGDTFIKTGKAKELKKWDFGPPPHILVVPGELH
FTEEEFLNLFL
>A0A835X764|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFAGLGISGPDGLGINTVKILNQADIVYLEIFTNPIAKSHVAKIKKLVKGQLKLAPRW
LVEDGKEILQNAKKKKAVLLSYGDPYIATTHIELRTRASLEGIKIQTIHAASGLTSLIGE
CGLHYYKVGRPVTITKEIKPTTSAYYAIYHNLISGNHTLLPLEYDQNKNFFLDPKDAFAN
LISTEKGELRKVIDKSSYAIVASRVGSKTQQITAGKISSLQKIDFGKSPHTIIIPGKMHF
TEVDALKTCVNCLDEPFDNSSKTSKISEQMIRKYTPMIRKVLKEIAPQFKEDKNISLVLE
NAKHYVEDAEKFQSEGKDELAILAIGYADGLVDALRMSKGISTNDSVYT
>A0A4U7D2F6|diphthine synthase|EC 2.1.1.98|Halorubrum sp. ASP121|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLIGADVADLEAYHDVDIAVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYGHGGDDVPASVVETVEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADAAAELLAEGWADELAVAVARAGSPDAVVAADRLSALADRQFGDPLHLLVI
PGDLHHVEADALVGLADAPDALVEE
>A0A520K287|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon ANME-1-THS|TrEMBL
MLTFVGLGLYDEKDITVKGLEAIRAADLVYAEFYTSPLGGKTVEKMEKMYGRKIVLVQRS
DLEEYPEKLILTPAKTQNVVVLSGGDAMIATTHVDLRLRAIERGIETRIIHAPSISSAVA
GLCGLQNYKFGKSATVSPPYKEVISEVPYETIRANKERGLHTLLYLDISMDIHEALRLLE
AVEDQKGGAMLRTSLIVGIARAGSAKPVVKADYMEGLKTYDFGALPHVLVVPGELHFLER
EALIKIAQAPEKI
>A0A101J0C8|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon 53_19|TrEMBL
MLTFIGLGLFDEHDISLKGLAVIREADAVFLETYTSRLMGADMPALEALYQQPIRLLSRE
DVEQHPEPILDAAESGSAVFLTAGDTMVSTTHADLRIRAAERGIRTTIIHAASIASAVCG
LSGLQNYRFGKSCSLPYPEARWMPTTPVEVIAANRSQNLHTIVYLDIQKERYMRISEAIA
IIEEIGARLTITIPLYVGIARAGSDDPVVIAGTGDDLKRMDFGPPLHILIVPADLHMIER
EYLELFAGLPPESDSIQ
>A0A117STF9|diphthine synthase|EC 2.1.1.98|Caldivirga sp. CIS_19|TrEMBL
MAGTLYIVGVGLGPGQITQEAINVLRSVGEVFIEEYTSMFETSLGDHIAKVVGRMVVKLS
RRDLEEESGRVIINAIRERGSAALAVIGDPMLATTHSALVTQATQLGIRVRVINGISIVC
AAVSQAGLSLYKLGPVATVTYERGGVLSKRAYEVLAGNISRGLHTPLLLDIKDEGGFMSI
REAVDVLIRLEDEVKQGIVSDDLAAVFESRIGWSDQAVVVASLTNPPDLKPPSVILIPGL
LNPVEEEYLRVVHGAGEELLRRHINHVKALMRTMQHSSG
>A0A3G1A7M8|diphthine synthase|EC 2.1.1.98|Thermofilum adornatus 1505|TrEMBL
MLVIAGIGLFDLRDIPLGLLEEVKDASAVFIETYTSVLPGFSVDKLSRLLNRQIIQLVRA
EIEDKGAKIILEKAKNEKVILLVVGNPLLATTHASIIIDAYRLGITVKVIPAASVIDGLI
VSTGLHAYKLGKIVTLVFPEDKELKNYPYTPYQTLSDNLSRGLHTIFLLDIRQEERRYLL
APEAASLLLKIEEKFKENVLDDDTLAIAVARATADNEQVYVGKLSELAARDLGEPPHTLV
IPGLLHDSEIEFLYYKTGTAIGVFKDWNKKLIARIMQRNT
>A0A7J3VUJ4|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
MTLVFIGGGLGSPSSLTIGAVEALKSCDVVYIDCYTSFWDERTFEYVGGLAKSLVKSYRR
MLEEEAHKVVAEARTKVVGVLAPGDPFIATTHSSMMEMAARKGVKVEVVNGVSIISAAIS
LSGLHVYKFGKTATLPKTEDPALYTQPVNIIEENLSRQAHTLLLLDTADGGLSVDVGLKR
LMQAAEKMGKRVVGYETLAIALARVGHSDQVLKAGRVEDLLADSYPPPPHCLIIPSALHF
SEKEAVKTYALNPDAVEKTVPPNPVADRITRYLDKCRQFIRRAGGFEHLKQYVNYVKCYV
EDAEKFMQSGDVVNALLSVGYAEGLLDALRLRGEVDFEW
>A0A832UY22|diphthine synthase|EC 2.1.1.98|Candidatus Naiadarchaeales archaeon SRR2090153.bin461|TrEMBL
MIKIIGLGLWNEKSMSIEAMEEANDCDVLYAEFYTSRLIGLRSKEELVKVLGKDIKFLKR
EEVEVSQKFILDRAKKEKVGFLVAGDALTATTHIDLVIEAKKRGIEVKIIHGSSIYTAAA
GLAGLQIYKFGRSCSIPYPQPGFKVESPFEVIAGNLKQGLHTLVFLDIQPDKLMTANEAM
QILLEIGKKKKSRILDNKEIVVVARAGSDEAVVKYGKIKDLIEMNFGEPMHIIIVPGKLH
FKEKEYLEFCR
>R7PSM2|diphthine synthase|EC 2.1.1.98|Methanobrevibacter smithii CAG:186|TrEMBL
MFLKSYIMFYLVGLGLFDAGDISLKGLECLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A133U3Q2|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA259A05|TrEMBL
MLAFVGLGLSRGGITLQGLEEVRSADKVYAELYTSLIPDFDLEELEKKVGQPIEVLKRED
VEGKPDEILKRAKDEKIAFLVPGDPMVATTHLDLRLRAKEAGVETKIVHGPSIETAAPGL
TGLQSYKFGRTATLPLPQKPSETPYEIIEENGKLGFHTLLLLDIEADEERYLTADRAIEH
LLALEDELDREVFTGETLCVVVARAGSETPLVKAHRARELKEMDFGPPPHAVIVPGKLHF
LEAEALERFAGAPEEV
>A0A2R6H8I5|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_4_66_20|TrEMBL
MLSFIGLGLYDERSITLRGRDALESADAAFAEWYTSRLSGTSVDRLEVLHGIEIEVRDRA
GVEQHPEPILDAAEEGHAAFLTAGDTMISTTHVDLRLRAHERGIDTRVIHGTTAQTAASS
LTALQNYRFGKATTLPFPETHGGVPDSVIDTVEANRDRDLHTLVYLDIDGENERFLTGDR
AADLLADPLGDPLGVVVGQAGSDDPTVRADRLSTLADESFGPPLHLLVLPGDPHPLEREA
LVELAGTPDGI
>A0A832TL77|diphthine synthase|EC 2.1.1.98|Methanosarcina sp|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTNLEKMEELYGKKVFLLSRE
DVEQHPDWLSKAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDIIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRREGVIRGAAAVGIARAGSEKPTVKADYAENLKDFNFGKPLHILVIP
GKLHFLEAEALVKLAGGPIRFMEEAE
>M0FHG2|diphthine synthase|EC 2.1.1.98|Haloferax sp. ATCC BAA-646|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEASHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVGWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A831XG34|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGLGLYSIRDIPLGVLDLLKKAEVVYFESYTSLAPSLNKEVIEALVGKKVKEVKRE
DLEDRSAQELLAEAHEKLVVLLTVGNPLIATTHSAIVLEARKRGVPFLILPSASVIDGII
CATGLHIYRFGRVVTLVFPDEERGFFPFSTYFAIRSNLSRGLHTLVLLDIRAEEKRYMDP
GYAAQLLLRLENMTSGGSLSENSLVIVVARATAPDQEVAVCTLGEAARRSFGQPPFSLVI
PGLLHATEIEYLHHVHGAPLEVMLKWNEHVRRKFSSTLEM
>A0A075GLR8|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote KM3_158_G08|TrEMBL
MTHHTRKSDKHYSLDDDGGWTMTNFESGLWLIGLGPGDLSAMTTASIEAAKSCNYRFLEG
YTALLPSGEGAKLVEIVGEYELLMRPEVENPDRLLELASENAVALMIVGDPLQATTHVDL
QLRAKAAGINCHVIHGISITTIVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNL
QRDLHSLVLLDLDPTGMGIDEQKPMSPAMAVDILRRSADKIGENIEQWKIVLCSDMGRPE
QRIFYGTLDDVESINNGSIHCIVIPGRLDELEVEALARWN
>A0A1I2N105|diphthine synthase|EC 2.1.1.98|Halopelagius inordinatus|TrEMBL
MLTFIGLGLYDERSITVEGRDALRDADHAYAEFYTSKLLGATVDELRSHHDVDIEVRDRE
GVEQRPEEILDAAEAGDVAFLTAGDTMISTTHVDLRLRAIERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVVDSIDANRERGLHTLVYLDIKVADGRSGSP
DDEYGEYMTADFAAGELARDWDDVLGVVVARAGSPDAVVAADRLSALSERDFGDPLQMLL
IPGDLHHVEADAVRTLGGAPDDVVSENEL
>A0A1G5UW19|diphthine synthase|EC 2.1.1.98|Methanobrevibacter millerae|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFDEIESLIGKKIEVLVRG
EVEEEHKFIEEARDSDVALITGGDPLIATTHSDFLIQCSKKGIEYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYMAIEENLKSNLHTLVLLDIQAHNDRYMTVNEGL
EYLMNIRDSLDYDGLVGEDTLAVGIARVGSSDVVVKAGKISDLIDFDFGGPLHCIVIPAE
LHIVEAEYLVEIAGADSSILDDV
>A0A2T9X1J4|diphthine synthase|EC 2.1.1.98|Acidianus hospitalis|TrEMBL
MLYFIGLGLAKKFLTQASIEAMRKVDVLYLDAYTSLSCDINKEYLEKLLGRQIILADRST
LENNSKNIIKLLKEGKSVGIATIGDPMIATTHVSLATEAKNKGYNVIIIPGISVHCYIIS
KSMLSSYKFGRSVTVVYPYDKILDTTPYEVIKDNSSRGLHTILYLDLKEGKPMSAKDAIS
LLLQMEEIKKEGIITPNTQIIIGQRLGCEDEEVKALTISEALEYKYKDPPHIIIVPSKNL
HYMEVEALKCLH
>M0CGG1|diphthine synthase|EC 2.1.1.98|Halosimplex carlsbadense 2-9-1|TrEMBL
MLTFVGLGLYDERSVTVAGREAIRAADRVVAEFYTSTLAGATLADLETAHDTEIEVRDRA
GVEQSPEDILDDAADSEVVFCTAGDTMISTTHTDLRLRAHDRGIETRVVHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHAGDDLPGSVVATVEGNRDRGLHTLVFLDIDGENEAYMRA
DRAAARLADAYEDTLGVVVARAGSSDPVVRADRLSALAERSFGDPLHLLVIPGDLHLMER
DALAALGDAPTELLDELVV
>A0A109UUS6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp. YE315|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFDAIEELIGQKIEVLVRN
EVEEESKFIDEAKTSDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEAIEENLKMDMHTLVLLDIQAHKDRYMTVNQGL
EYLMNIHDTLEREGLISEDTLAMGIARVGSKDVCVKAGKIKELLGFDFGGPLHCIVIPSK
LHIVEAEYLVEIAGADSSILDDV
>A0A2R6FB30|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_8_67_36|TrEMBL
MRSGLYDERSVTVEGRDAIRDADRVFAEFYTSRLVGTDLDALEAFHDTDIEVRDRAGVER
NPDPVLAAAETASVVFLTAGDTMVSTTHADLRIRAEERGIDTHVVHGTTARTAASSLTGL
QNYRFGKATTLPFETAHGGDGVPDSVVATIEDNRARDLHTPVYLDIKVDDPHWAESDDTY
MTADRAARLLGAEFPDRLAVVVARAGSPDPLVVADTLANLATRDFGDPLHLLVIPAELHP
IEDEALSAVAES
>A0A832SBN5|diphthine synthase|EC 2.1.1.98|Methanoculleus sp|TrEMBL
MLTFVGLGLYDLGDITLKGLTYVKSADVVFLEAYTSRLMGTDLTTMEVFFGKEIRVLSRE
DVEHDPAEILERAAAGRVAFLIGGDPMVSTTHADLRIRAAAAGIETSIIHAASISSAVCG
LSGLQNYRFGKSCSVPFPAGGWFPTTPIDTITVNLGLNLHTLVYLDIQDDRCMRIPEAIE
IIEEMAERRGVEPPALYVGIARAGSEHPVVAAGSGSKLKETDFGPPLHVLAVPADLHPVE
REYLETFAGL
>E8R725|diphthine synthase|EC 2.1.1.98|Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)|TrEMBL
MLAFIGIGYSRRHLTQESLELLRSAEKIYIDTYTSMYEDGYEWIRDVNPSAEIIVARRRD
LEGDAITRIVEESVRKNVAIVCAGDPFTATTHDAIRVEALKRGVEVRVATGISIVSLVHS
RIGLQAYRFGKIVTLVYPDNFKPYSVVETIYDNLSRNLHTLILLDLRLEEGVAMTIPEAV
EILGGLDDKGLILDQVGVAVARLGWSSELVKAGRVRELGKHRYPPPPHSLIITAKLHPVE
LESLRYIAGLQL
>A0A1S8AUC9|diphthine synthase|EC 2.1.1.98|Haloterrigena saccharevitans|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRAYAEFYTSELIGTTIEDLESHHDTAIEVRDRA
GVEQHPEDMLEAAETEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETTDSNRADGLHTIVYLDIKIGHERTDED
EYMTADVGAELLAEEYPDLVGVVVARAGSPDPIVEAGTMTELADREFGAPLHLLVVPGEC
HLLEADALEELAGADRDALDIA
>A0A2H5V3N0|diphthine synthase|EC 2.1.1.98|archaeon HR02|TrEMBL
MLRLVGLGLGPPEYMTLKAIKALEESDIVYLDTYTSPLPSELVEFLRSRLGERLRLAERS
DLEERVAELVDKAATMSVAVAVPGDPLIATTHIAVLMEAAGRGVGCEIVYGVSSVSAAIG
SSCLSSYKFGRIVTVPRDASGESLKTIYRCVEENIEAGLHTLVLLDVAGGGLSASEAVRM
LLDAGAEVGGRLGPDSTVIVLARLGYRDEVRVACRASDVSNLHLPPPPHIVIIPAELRSY
ERDAINKLMRVDEGLLKPHKPASHRRARAERYVAKASSTLTRLQILSGDAETRRVLELAR
SYVEDAKFFLNSDMADDSLIAVSYAEGLLDCLRALGKVEFTW
>F0NHI2|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain REY15A)|TrEMBL
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSERAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>A0A662MVH7|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MAIYFIGLGLYDERDITLKGLEIARKCDLLFAEFYTSLLAGTTIEKIQEQVGKPIKRLNR
EDVELNFERIVLKEAKDKDVAFLTAGDPMVATTHSDLRIRAKQMGIESYVVHAPSIYSAI
AITGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQGRYMTANE
AMEILLQVEEMKGERAFTEDTLVVVLARAGSLNPTLKAGYVKDMVKEDFGRQPHVMVVPG
RLHIVEAEYLVEFAGAPKEILDEA
>A0A497RZR0|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYFIGLGLYDEKDLSLRGLEIIKKCSEVYAELYTSFFHGDLKKLEELSGKKIRILGRED
LEEKSSKLIEKAKKENVAILVPGDPMIATTHAAILIDAMKKGIKTKVVHSSSIYSGIGET
GLHIYKFGRTVSLPYPQDNYMPESPYLYIKENLDLGLHTLVLLDVKAEQKKFMSINEALR
ILLEIEERKRLGVITAEKEVLGISRLGSDDQLIRYGAVKKLIELDFGKPPHSLVIPGKLH
FMEEEMLNFFRI
>F8AMJ1|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)|TrEMBL
MLILAGLGLYDEKDMTLKTLEYAKKVDKIYAEFYTAVLTGTTIEKIEKTLGKEITVLNRE
KVEYETEKLINESKDKDVMFLTAGDPMVATTHVDIAVEARKKGIEVIIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEPNYFPETPYNVIKENLKMGYHTLCLLDIHADENKFMTANEGL
EILLKIEEKRKENILNENTKVIVVARAGSLKPKIVYGKIKDLLKHDFGKPLHCIIIPGKL
HFMEEDALKYLCENL
>A0A7Z7B1H9|diphthine synthase|EC 2.1.1.98|Methanolobus vulcani|TrEMBL
MLTFIGLGLFDEKDISLKGLEAIKNADMVFAEFYTSRLMGSSPEELESLYGKKVNLLSRE
DVEISPDWLSEAKDKNVAFLTGGDTMVSTTHVDLRLRAKNLDIETKLIHGSSIASAICGL
SCLQNYRFGKASTIPHPYTSSRGVTVVSETPYDTIKLNKENNMHTLVFLDIDKDKGYMTV
NQALSLLLQVEDKRGEGIMENAIAVGIARAGSEAPIVKAGYAHALKDEDFGEPLHILVIP
ASLHFIEAEALVELLGAPAEILEGLDD
>A0A0M9AHF0|diphthine synthase|EC 2.1.1.98|Haloarcula rubripromontorii|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTGLETLADALETSIELRDRA
GIEQDPEPILEAAEREHVVFCTAGDTMVSTTHTDLRLRAEDRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEANQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTARQAAAMLSEPFPDTLAVVVARAGSPEPLVVADTLDELATQTFGDPLHLLVIPG
SLHPLEADALESLAGAALE
>A0A7C4FG81|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLAFVGLGIRGEESLTLEGLKELQQADEVYAELYTSPLPKLELPNLEKIIGKRVKVLDRR
EIEEGEELLKASAVKRVVLLVPGDPMIATTHVALRLKAISLGIQTKVVHSSSIISAVAGL
TGLQNYKFGRSATLPLDQTSAHPYEVLGENLERGLHTLLFLDVKAEESRYMTANEGIRYL
LQLENQRQRGYFTGKRLAVIVARAGGDDCLVRGDRAEKLAEVDFGPPPHALVVPGKLHFL
EAEALKTLAGVPPEILAKQESLQVKGLKEELLEEIEKWIEKLEKKVEPLKSRPEMENILA
YLQDSEHFRKRGDLVKSFECLIWAWALLHTSRDKLVEG
>A0A537DG34|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVRAPNLRLSLLARNNASPAKKRPFSKPAHSSAVMSVTFVGLGLTGENGLTVQGLEEARK
ADAVFAEFYTNLMPKVDVRKLEDLLGKKVVVLSRVQLEDEGGKQIVEAALGKRVVFLVPG
DPMIATTHISVRLELARRGIPSTIVHGPSITSAVCGATGLQSYKFGKSVTLPHEPGVPGS
VLDTLRDNGKRGLHTLILLDVRPEQSKQLTIDEAAAKLVVADPGLQSSLGVGVARIGSDD
QFVLSRRLETLRHQEFGKVPHSLVVPGRLHFMEAESLKAFCGASDEDLEALR
>A0A537GX69|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVVFIGLGLNDERGLTIEGLEEARRSGSVFAEFYTNIMPGLDRKKLELLLGKKIVELSR
VQLEDEGGKQIVEAVERGRVAFLVPGDPMIATTHVSIRLELAKKGIPSRIIHGPSITSAV
CGATGLQSYKFGKSVTLPHESGVPGSVLDTIRDNGKRGLHTLLLLDVRPEQSKQLTIGEA
AAKLVVADPRLQRSLGVGVARIGSDDQFVLSRRLETLQHQEFGKVPHSLVVPGKLHFMEA
ESLKAFCGASDEDLRSLK
>A0A832TL62|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLNDEKGISVRGLEETRSADSVFVELYTSLLPGFSLHRLENLVGKKVVVVS
RRDLEEENGRSILNSAKQGKTVMLIPGDPFVATTHITLRIEAEKQCVKTRIIHGVSIISA
IIGFSGLHNYKFGKTVTVPFPENSSETPYNVVAQNKKFGLHTLCLLDLKVDEKRFLTVRD
GLEHLLTVEHRRIENIVTPETIVVGVARVGSANPSLKADYAGKLLAYDFGDPPHSLIVVG
QLHFMEAEALISLASAPKELREVAK
>A0A7C5TMW1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLKLIGLGLNVYGITLEGLIEVRSCEKVYVELYTSIIPGLTLDILKNVIGREVILLRRRD
LEDECERIIREAGRYDIALLTPGDPLIATTHISLVIEARKKGIPVKIVNSASIISAISSA
TGLQIYNFGRVVTLTRSTPPSLTVYNVVEDNLSRGLHTLILLDLDVEKGYWMSISEAVDI
LVSMEDEVRRAVFDGDRLVLGVARVGSVDAIVKADKLSRIKQYDFGGPPHSLIVPGRLHF
MEVEALLCLAGAPQDLLKKS
>V4YAL1|diphthine synthase|EC 2.1.1.98|uncultured archaeon A07HN63|TrEMBL
MLTFIGLGLYDEHSITREGETALRDADRVFAEFYTSRLLGASVEELETHHDIEIEVRDRA
GVEQDPEPMLAAAAEGDVAFLTAGDTMISTTHADLRVRAAERGIDTRVVHGVTAETAASG
LTGLQNYRFGKAVTLPFPAVHGAGDVPPSVIESIDANRERGLHTLVYLDIKIDTHAEMSV
DDPFMRASEAAALLAESWGDELGIVVARAGSPEPVVAADRLSALADQSFGEPLHLLVIPG
DLHHVEADALESLAGAPPALLSDEV
>A0A650A5S7|diphthine synthase|EC 2.1.1.98|Halorhabdus sp. CBA1104|TrEMBL
MLTFVGLGLYDERSITLAGRDAIANADRIFAEFYTSRLVDATVADLEVFHDVDIEVRDRA
GVEQAPDPILDAAAAGDAVFLTAGDTMISTTHVDLRLRAEQRGIETRLIHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHGGDGVPASVIETIEANAERDLHTLVFLDIDVDDDREAYM
AGDTAGELLAEHWRPDALGVVVARAGSPDPVVRADRLDALAEMDFGEPLHLLLLPSSLHY
IERDALATIADAPESLLEDSLAE
>A0A850SES1|diphthine synthase|EC 2.1.1.98|Nitrososphaera sp|TrEMBL
MLWFVGTGINGHLGLSLAAVDVLKKCDIVYIERFTSLLGKKELAGLDSIIGKKAVPVQRW
FVEDGREILEAAKEKQVALVTYGDPLIATTHSELRTRAAAGSIKTGVLHAASGIASIMGE
CGLHMYKFGRTVTMMSEPKSAISVYNTVFDNLLLGCHTLVLTEYSHDEQKGAFFLDPCTA
VRMLLDVERDQRHGVISEDTFVIVASRIGAEDSRIVSGKIKSLAGVGFGQGPHSLIIPGS
LHFTEHDALEALTVSLDPPSDNAKSTRRISVQMVERYAPKAKEALSQMRNILRKEQGDNK
GMFEVLDNAEFYIADAERFLSQGKHELAVLSMGYAEGLIDALRFQKGINPWNP
>A0A2D6JBU7|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MIKIIGIGLWDEKSMTLQAQEEAADCDFLYAEFYTSKMFGSSLKKLETKIGKDIQELSRE
EVESGKELLEKAKKQKVGLLVGGDAMTATTHTQLILDAEEAGVESKIIHGVSIVSAAAGL
SGLQVYKFGKTVSIPFEDVESPYNIIEENKSIGAHTLCLLDIQDGKFMTVNEAMKKLLKI
EKVREEKVFMKDTLVVGIARAGSPKPVVKAGRVEELLKKNFGEPLQVLIIPGKLHFAEEE
ALELLKK
>A0A534MTD2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFVGLGLDDEKGITLRGLEEARSADVVFAELYTSALPGASLEAVEKLIDRKIHRLS
REEVEDGQVLLTAAASRTVAFLIPGDPMSATTHIDLRLRAARAKIRTRIVHGVSIVTSAA
GSLGLQVYKFGRTTTVPFSSPGFAPTSPLEVILDNRRMGLHTLVLLDLREDGSFLAPRDA
IASLLRMAAAVNTSEFGSQTLGCVLSRVGSPEVRGFAGPIADLADRDLGPPLHCLVIPGT
LHFLEKEALVTFAGAPHDL
>A0A534LXP7|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLHDEKGVTLRGLEEARGADMVFAELYTSTLAGASLESVERLVGKKIRILG
RAEVEDGHTILAAAAGQRVAFLVGGDPMAATTHVDLRLRAASAGIPTRIVHGASILTAAA
GVLGLQIYKFGRTTTIPFPSEGFGPTSPLEVILQNRSAGLHSLVLLDLREDGTFLLAGDA
IGLLLQMAAKIGTAEIGRRMLTCALSRVGSREGLAVAGPLGELPARDLGRPPHCLVIPGS
LHFLEKEALIAFAGAPRDFSEGPSRVPRGGRSART
>A0A534JVM6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFVGLGLHDEKGITLRGLDEARSADVVFAELYTSSLTGATIESVERLIGKKIRTLT
RADVEDGGTILKAAARQKVAFLVVGDPMAATTHVDLRLRAAAAKVPSRIVHGVSILTAAA
GALGLQAYKFGRTTTIPFPATGFGPTSPLEAILENRRAGLHSLVLLDVREGGTPLAPKEA
IAFLLEMAPKIGTTEFGPETLACVLSRVGSPDVRAVSGPIGTLSNRDLGPPMHCIVIPGR
LHFLEKEALIAFAGAPHDF
>A0A7K4MYM6|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKTSKSSTVVLLSYGDPYVATTHIELRTRAKLENIETSTIHSASAITSMTGE
AGLQFYKVGRMVTIMNEKKSTITPYTAIFKNLTQGLHSIILLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVVNNDTFAIVASRIGFKTQKITSGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSSRIKSTSIQMIEKYVPMVRDTLEEIKSLYNDSKEFQVVIQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKI
>A0A7J4M819|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLYLIGLGLSERGISKEGLDAIEKCKKIYLENYTVDFPYTEHQLEEMIGKKFKVLNRAQV
ENLSIIDEAEKLNVALLIYGSPLSATTHITIINECRESGIKYKVVYSASIFDAVAETGLQ
LYKFGKVSSMPAWQKSFEPDSFMEIVKQNLSIEAHSLILIDIGLEFNKALNQLKIAAKKH
EIQLEKIAVCQALGTKNRKIMYRTIEEALEYSGVLKPYCIIIPGKLHFLEKEILEGFSKR
KD
>A0A0B5GJQ1|diphthine synthase|EC 2.1.1.98|Haloarcula sp. CBA1115|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A2H9PLU7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG_4_10_14_0_2_um_filter_33_13|TrEMBL
MTLYLIGLGLSTEKDITIKGLETIQKCDLVYLENYTSLLQCTLEDLKKLYGKKLILANRE
ITEQGEDKIIEEAKSKEVAFLVIGDPFSATTHVELFKSAREKNVKVKIINNASVLTSIGI
TGLQLYKFGRTASIPFLEEIPQLEAPYNLYRENTYLGMHTLFLLDLRPDLNKFMTINRAL
EILENIEKRKGEKLIKDDLLVVGCARLGSDDFLVKSGPLKEIKMFDFGKPPHCLIIPGKM
HFMEEDLLRLWE
>A0A1V6JXC7|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ADurb.Bin009|TrEMBL
MLTFVGLGLYDPGDISVKGLECVKGADVVYLESYTSRLMGTDVAGMEAFFGKEVRVLARE
DVEQDPRDIIEHALHGHVAFLTGGDPMVSTTHADLRIRAAAAGVATAIIHASSISSAVCG
LSGLQNYRFGKSCSVPFPAKGWFPTAPVETIAANLACNLHTLVYLDIQKDRYMRIPEAIA
IVEEMAAKRGIEPPALYVGIARAGSACPVVAAGTGADLKETDFGPPLHILVVPGDLHPVE
REYLEIFAGL
>A0A6A8GCM2|diphthine synthase|EC 2.1.1.98|Haloferax litoreum|TrEMBL
MLTFIGLGLFDERSITVEGREALADADRAFAEFYTSHLVGATVEDLEAYHDIDIDVRDRA
GVEQDPDAILDAAEQEHVVFLTAGDTMISTTHVDLRLRAEERGIETRVIHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRERGLHTLVYLDIKVDWEGRRGV
DVEGDEYMTADYAAELFAEHWDGDALGVAVCRAGSPNPVVAADRLSELAGRDFGDPLHML
IIPGEVHHVEADALMGLGGAPTDLFDHDER
>A0A1D3L315|diphthine synthase|EC 2.1.1.98|Methanobacterium congolense|TrEMBL
MLYFIGLGLYDAGDISMKGAEALKNVDTIYAEFYTARLFGTNISTLEEMLGVEITILTRE
QVEEENIPLKEAEKKDVAFVSAGDPLIATTHSDLMIEARKKGIKTRVIHSSSILSAAPGI
AGLQAYKFGKVTTIPFPEENYFPHSPYLAVKENMDSKLHTLVLLDIRAHEDRYMTANQGL
EYLMRVESERGENLISGDTLAVVIARAGADKPVVRADKIEKLLNEDFGGPLHCLMIPGDL
HFMEAEALVVLGGAPPEILEEDL
>A0A8J8PS22|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. D5|TrEMBL
MGVLNLVGLGLAKKFITKSAVDALLNSDFIFFDRYTSKSCDINTDSLKEILNGKDVIEAN
RDLLENNSKIMLNYLDNNYKVSIATIGDALIATTHVSLALDARKRGHIVNVIPAVSVHCY
IVSKSFLSSYKFGKSVTVTFPYDNFIDYGPYHVIRDNKERGLHTIIYLDLKDGKAMTAND
ALNILLSMEDKHRMNVISKSNIVIVGARLGCENEKVIAMTVEEALNYDFGDTPHIIIIPG
TLHYMEADAIKWMLMT
>A0A2H9RI53|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum sp. CG_4_9_14_0_8_um_filter_32_206|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>A0A3R7VDG0|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED248|TrEMBL
MATENELIFPKCGLMLIGMGPGKISSMTIEAKQAAIAADYRRYEAYTALWPDEEXVSLES
EIGKIEMVMRPEVENPTALLELSKSSLVALLVVGDPLQATTHVDLQLQAMEAGVNCLVFH
GISITTLVTGAVGLSNYKFGRQTTITYPYSGWIATSPLEVVAMNRFYNQHTLALLDLDPT
GAGTGKQAPMQPKDACHSLKLMKEKMRLVDYDITEDSKIDIVKKSAFEEFIKLDFSDIKV
VLCADMGTKDEKITYTTVAKLENMVGGRLNCLIFPAITSEVEEKALLXWQ
>J3EYI3|diphthine synthase|EC 2.1.1.98|Halogranum salarium B-1|TrEMBL
MLTFIGLGLYDERSITVEGRDALRDADRAFAEFYTSKLIGTTVEDLSAHHGLDIEVRDRA
GTEQDPTPILDAAEEEDVVFLTAGDTMISTTHVDLRLRAVERDIETRVIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGGDDVPKSVVDSIEANLERGLHTLVYLDIKAHRDEYMTA
STAAEMFADGWEDRLAVVVARAGSPEPLVAADRFSALAEREFGGPLHMLVIPGDLHHVEA
EALETLGGCPSELLDPL
>A0A3M9ZFI8|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon S14|TrEMBL
MLTLVGIGVGGARSMGAGAREAIASARAVYMETFTSPVPAGDVEEVRRAAEEGGAAFRAV
PRWAVEDGGEILRAAASGDVALVCYGDPYVATTHIELRARAAAAGTPTRSVHGASALTSV
VGECGLHQYKVGRTATVTRAEASTPYGVLRENVERGCHTVLLLEYDEDAGAFMAPREALA
ALLAVEGERRELALTRETFAVIASRVGTAGQAIAAGSVDHLMGLDAGEPPHSIVVPGALH
FTEADALRALARCEGEPRSNSETARREAHRMLARYVPMVGAAMREARERGADERVLDCAR
DYVADAEEFLRRGREGQA
>A0A842UZ93|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLCLVGLGLATERDLSLRAFNVLAGCDVVYLEGYTGVFDRLSELEDLLDRSIHVLSRQEV
ESSPELIERARKHNVALLVQGDPFSATTHVSLILDCVDAGVKYLVVNSSSVFSGVARTGL
SLYKFGKTASIPFPGKNFKPDSFLRVISDNLKIGAHTLCLLDVESDAHDFMTIPEAVRII
ERADKKDSLDYRWVGCARLGFPDEVVKWVKPSTLKRFDWPAAPHCLVIPSKKLHFMEKEA
LKMLSD
>A0A7J3DNY3|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
QIFLFMLYLISLGIFDEKDMSMRAIECAKKCDFLFFEKYTAKPKTNAKKLSEFLGKEVKE
IGREDLEENSDDIIKMSEKNNVGIIISGDALIATTHISLILEARKRGIEAKVIHGSSIYT
AVCSSGLQIYKFGRTVTLTKRGEKSTIKEIKENRKRGLHTLVLLDIDLELSDAINILLKS
KAIKENEKIVLYSNLGEYEIIKYISPKEFFESDFFKNLKEEQFSIIIPGKLHFIEEEALS
LWN
>A0A5E4LKC6|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MTLFLVGLGVSCDITLSGLEAIQTADNVYIETYTNPLDEETIQNLEKKTGKKFEKLERDK
LESSFLVNQAKSSNVCVLISGDPLTATTHVTLVVEAKQKNIPVQVIHNSSIYSTAPARSG
LQIYRFGKTASLVNPRPNYKPVSSLDIIRENLTRNLHTLVLLDTEPQPMEAKVALEMLSE
FETAVVLSCVGHKDEKIVFGKVKNLIGIELGKPPFTLIIPAKLHHIEEEYLNLF
>A0A3R7URV3|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED141|TrEMBL
MPLIVTTGQDGISMTVDLPPTGLLLVGLGPGGRSGMTAAAIEAAQTADHRWYEAYTALWP
EQDVIDLEAHVGPIERVMRPDVEHPTEMFELARTSLVALLVVGDPLQATTHVDLQLRAED
AGVPCRVLHGLSITGMVTGAAGLSNYRFGRQTTLTYPHGAWIATSPLETIALNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHMMAERLAERPPEEGALSSLTSADLEGLDVGA
WTVVLCADVGTSDEAFVTTTVDGLPSEVGGRLNCLLVPAAIEGVEAAAIARWRRS
>A0A0E3SSR8|diphthine synthase|EC 2.1.1.98|Methanococcoides methylutens MM1|TrEMBL
MLDFVGLGLYDEKDISLKGLEKIRNADKVYVEFYTSILMGTDLEKMEELYQKKITVLSRE
DVEQHAEDWIADAKDMNVVFLTGGDTMVSTTHVDLRLRALAMGIETTLVHGASIASAICG
LSGLQNYRFGKAATVPHPYVTSRGTRVISETPYDTIKMNRDNGLHTAVFLDIDKEKGYMT
VNEALSILLEVEGKRGEGVMNDRIAVGVARAGSPSPVVKADYAEELNDFDFGGPLHILII
PADLHFVEAEALVKLAGGPEEILEDVE
>I0A202|diphthine synthase|EC 2.1.1.98|Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)|TrEMBL
MPIIMTNNEITNGKCLGELSFVGLGLSLSHISIEGIKKLKSSDFIFLEGYTSFYFPEINA
AMKVIGIKSDRFKIISRRDIEEKSGQEIIDLLLKGKNISMAVIGDPFIATTHLSLKNYAK
EKGCKVNYIPGINIFSYAMSATGLFNYKFGPSATIVYKREGILSVYPYLVLSGNLSRGLH
TFFFLDIDAERGPLNASEAIKLLIEMEKEERLGIITPETKIVVLERLGWPDEKIYYGKIS
LLYNMRFNPPNSIIIPGKLHFMEEQSLEAFSIERNER
>A0A523B8F6|diphthine synthase|EC 2.1.1.98|Candidatus Nezhaarchaeota archaeon WYZ-LMO7|TrEMBL
MLRCASLSLIFIGIGLTAKGLTIEGLSEAQKAEHVFIDAYTNLIPRNELHTLQNLIGKDI
KPLYRSDVEGRGVYELLKLTEKSTVALLVVGDPFIATTHIALRLEAIKRGVKVKYVPSAS
IASVIPGLTGLSSYKFGKSATIVFPDKGSNNAAYDAIKDNSSRGLHTLLYLDLEVENKRA
MTINEALKLLLDVEAQRAEGVVREDMLIVGIARACWNNEIVKAAKLSKLINYDFGPPPHV
LVVPGSLHFMEYEALKALAGMED
>A0A1Q9P9A9|diphthine synthase|EC 2.1.1.98|Candidatus Heimdallarchaeota archaeon AB_125|TrEMBL
MGELIFVGLGLCDEKDISLHGVEEIKEADAIFAELYTSLMPGLSVQRLEKLVGKKISIVS
RRVLEEEEGGAILQQAKKGKTVLLVPGDPLIATTHVDLRIRAEGQGIKTRIIHGASIISA
VIGLSGLQNYKYGRSVTIPFPENGFISETPYRVIGENRKRGLHTLCFLDIRADEKRYMTV
KDGLETLLAVEKRKRSQVIRRDTLVVGIARAGSKTPIVKAGYVENMITYDCISLYLLYC
>A0A842VCJ7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MSLAFIGLGLATEQDVSTGALELIQKADVLYLETYTSVLQCSIKDLEKFYGHDIIKADRE
LVEQRAEDTILHDAKTQQVCFLVIGDVFSATTHLDLYRRAKELRIPISVHHNASVLTAVG
ATGLQLYKFGKVTSIPLEHEQVTTPYEYLGQNKSIGAHTLFLLDLRPDENRFLLIREAIE
YLLQQESKQKKGLLTKKTKAIGCARLGSKDAVIHYGTLEALTRQEFGNAPYCLIIPGVLH
FMEEETLQLYTIRQ
>M0AXR9|diphthine synthase|EC 2.1.1.98|Natrialba asiatica (strain ATCC 700177 / DSM 12278 / JCM 9576 / FERM P-10747 / NBRC 102637 / 172P1)|TrEMBL
MLTFIGLGLYDERSITVEGRDALRDADRVYAEFYTSKLLGTTVPSLEAAHDIDIEVRDRA
GVEQHPEDILGTAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGPATTLPFPYAHGADGLPASVTETIDENRADGLHTVVYLDIKVGHSPTSNQ
NPQDSDDKADRDDEEFMTADVGADLLAAAYPELVGVVVARAGSPDPLVEAGTMSELADRE
FGEPLHLLVIPGECHLLEADALVELAGAERNALDVV
>A0A842USI1|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGLGLNDEKDISVKGLNLVKKADFVYLENYTAVLNCPIEAIEKLYEKKIILADRN
MVEKDPEKTILKDAKDRNVAFLVVGDPFGATTHMDLLMRAKKAGIKTQVIHSASIISAIG
ITGLQVYKFGKTTSIPFPEKDFEPETPYDVIKENQKIGLHTLSLLDLRPKENKFMTINDA
INTLLKIEMRRNEKVFTSNTFCIGCAKIGSLDQKIKAGKASELLKYNFGPGLHCLVVPGK
MHFAEEEVVERFKN
>A0A7J4V0W1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
AAEVVFAEFYTSTLRKGSIERLEALLGKSIRVLGREEVEDAKVILDACKDKNVVLLVAGD
PMTATTHADLRIRAHMAEIETRVVHGPSVFTSVAGLLGLQHYKFGRTTTLPFPQEGYSPT
SPYDVVCENVARGLHTLILLDIDAASSRYMTANEGLHLLMDMEKRVGRGVITEDTVVGVV
ARAGSDDCRVMAGPLGRLLEVEFGPALHSIVVPGKLHFMEEEALKAFAGLG
>A0A640WBH4|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLSFIGAGLYGYDMSIEALQEARKCEKLYGEFYTSKLSISIEELEKVIGKKIIVLEREDI
EQSQKLIEEAKKLHIGFITAGDPMAATTHVELRLRAIEEGIETEVIHGISIVTAASSLLG
LQIYKFGRVISLPRPYGSYFPLSPYDSIKENIAAGLHTLLLLDIEGKPMTANEAMELLLK
MEEKRKEGIIKESTLIAVVSISHEKKIAKAGYLKEMIDEEFGPPLHSLVIPGKLHFMEAK
ALVKIADAPEEILK
>A0A3A5JNP7|diphthine synthase|EC 2.1.1.98|Halococcus sp. IIIV-5B|TrEMBL
MLTFVGLGLYDERSITIEGRDAVRGADRAFVERYTSTLGGASVADLEAYHDIEIEARDRA
GVERDPAAILDAAETEDVAFLVVGDPMVSTTHVDLRLRAHDRGIETRIVHGTTAQTAASS
LTGLQNYRFGKATTVPFAYGDRPIPESVVDTIDDNRDRGLHTLCYLDIKAAEDRYLTASA
AADRLAPALEDAIGVVVARAGSPEPQVAADTLARLADREFGDPLHLLVVPGALHDLEREA
LSALANAPDRLFADGS
>A0A662M000|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MAMGELIFVGLGLWSEKDITIAGKEAAGTCDKVFAEFYTSMLGVPEEKIEEVIGRPIEVL
SREEVEDGNAILDEAADKKVCLLTGGDPMTATTHIDLRLRAIERGIDTKVVHGISIMTAA
AGLLGLQSYKFGRTTTLAFPEGDYFPT
>A0A6B0T5S2|diphthine synthase|EC 2.1.1.98|Halovenus carboxidivorans|TrEMBL
MLSFVGLGLYDERSITVRGRDVLATADQAFAEWYTSRLAGTDVGTLEATHDIEIAVRDRA
GVEQHPEPILDAAEDGHTVFLTAGDTMISTTHVDLRLRAHDRHIDTQVVHGTTAQTAASS
LTGLQNYRFGKATTLPFEETHGGVPDSVIETIRANRQRGLHTLVYLDIDGENERFMSGDT
AAALLASELDDPVGVVVGQAGSDDPTVRADRLSALATESFGPPLHLLVVPGDLHPIEEDS
LSALAGLPD
>B3V675|diphthine synthase|EC 2.1.1.98|uncultured marine group III euryarchaeote SAT1000-53-B3|TrEMBL
MLTIIGLGLGGPNSITMDGVIALSISDHIFYETYTSPIHPETLDWVKLKSQKEPIHLSRG
QVEEPKEIIELAKEKNILLLVVGDSLSATTHVSLLLECKKNKVEYHVIHNASVLTAVAGV
LGLQHYNFGPVATLVLPEGNYKPTSPIDKIKANMKNGNHTLVLLDIKADQPETEPIYMTA
AQAAEQIIEAGLSGEIKVAAAARVGREDQGLWYGKLKDLAKLDLGKEPHSLVVPSKLHFT
EKDFLDNL
>C7P4P4|diphthine synthase|EC 2.1.1.98|Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541)|TrEMBL
MLTFVGLGLYDERSITVEGKEALQTATDIYAEFYTSKLIGTTIQKLEYYHDIDIELLDRA
AVEQTPDELLAAAEDGDVAFVTAGDTMVSTTHVDLRLRAEERGIHTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVETITANRERGLHTLVYLDIKVDDPHWEGE
QEFMTADHAAGLLADHFDTLGVVVARAGSANPVVEADSLDALADGDYGGPLHLLVVPADL
HEMERDALTTLADAPLAD
>A0A7J4SLN2|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon|TrEMBL
MLSFVGLGLYDVKSITMRGAEVIREADFVFLENYTSKLGGSGVEELEKYYEKNIEILQRE
DVEVNPEKVLEAAKEGEVAILIAGDPMIATTHVDLRLRANAQGIETEVIHGTSASTAACG
LTGLQNYRFGKSTTVPFEPVGKLPDSVYQTIEGNRERGLHTLVYLDIKIEQNKYMKGNEA
AKKLMGIGEDWIGIIIARAGSKNPRVVTGRLEKLSKMDFGKPLHLMVIPGELHHMEMEAL
ESFTEMHL
>A0A2G9M6Y2|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_45_16|TrEMBL
MTLYIIGLGLSDEKDITVKGLEAIRKCEYIYLENYTSLLQCTKEDLEEFYGKKIIMADRS
QSEQGSSEILEKARDHDTAFLVVGDPLSATTHIDLFREAKEQKVPVKVIHNASILTAVGI
TGLQLYKFGKTTSIPFIEDHPQLETPYNIIKENKERGAHTLCLLDLKPGENRFLTIPEAL
QILETIEERKKESLISDDLLVVGCARLGSTDPSIRSGTLKEIKKLDFGKPPYCLIIPGKL
HFVEEEMLNQAAFP
>L0JJ74|diphthine synthase|EC 2.1.1.98|Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB 786 / 157)|TrEMBL
MLTFIGLGLYDERSITVEGQEALRAAERVYAEFYTSELIGTTIEDLESHHDIEIEVRDRA
GVEQHPEDMLEAAATEDVAFLTAGDTMISTTHVDLRLRAHDRGIETQVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDANRADGLHTVVYLDIKIGHERTDED
EYMTADVGAELLADEYPDLVGVVVARAGSPDPLVEAGTMTELADREFGDPLHLLVVPGEC
HLLEADALEELAGADRDSLDIA
>A0A7J9TLR0|diphthine synthase|EC 2.1.1.98|ANME-2 cluster archaeon|TrEMBL
MLTFIGIGLYDKKDISVKGLEAIRRADHVYAEFYTSALMGTTVKEMEALYGREITVLDRE
DVEQQPEWLQRALTEKVVFLTGGDAMVSTTHVDLRMRAHELGIKTSIIHGSSILSAVPGL
TGLQNYRFGKSTTIPHPYTHKDRTIISNTPYDIIRSNLDSGMHTLVFLDIDPEKGYMTIN
LGCELLMEVDSQQGKPDLEQRLTVGVARAGSPSPVVVALPLVELAHYDFGSPLHILVVPA
DLHFMEAEALVKLAGAPEEILDMAK
>A0A0E3KD04|diphthine synthase|EC 2.1.1.98|Saccharolobus solfataricus|TrEMBL
MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEA
DRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTAN
EALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIP
GNLHYMEADAIKWILRS
>A0A7C4DVI1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLFSAAVVVVGELVFIGLGLFDCRDISLRGLEEIKSSDYVFAEFYTSLMPGFKIEDFRR
IVGKDLTVLSRKDIEDEEGRVLFEKAKYGKVAFLVPGDPLIATTHIALRVKAEKMGIKTK
VIHGASIISAAIGLSGLQNYRFGKSVTIPFPDNGVSQTPYIVICENKAMNLHTFCFLDIK
FEEAKYMSINEALKILLKLEEINRRGIIRGDALAVGVARVGSDDPIVKADAIKNLVDFDF
GSPPHSLIIPSERLHFMEAEALISLAGAPEWVRRMIG
>A0A7J2T9W9|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MLRLIGIGLSIDMLPLGNLKKILSCDEIVVDSYTSIWFPSAYLLTSLLIQLGKTVVIAPR
NYLEGGEVKNLIRRALDKEVCILVTGDPLIATTHSSIITEALVNNVEVEVVPAVSIFNVS
ISLSCLQVYRFGKIVTVVSPKNGIVYEYPYDVIKMNRLQNLHTLLLLEIDVEKNYYMKPY
EAIKILLDIQEKREENIISLKDIAIILGDVLSCRQKIWILTIEEILRMQYEFLYNKLYTI
IIPSRKLHPVEEECLNLIRKGKMSYLCAISEEELKKIAQLIYNQ
>A0A843EXA6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGVEALKKVDKVYAEFFTSRLFGSNFEKIESIIGKDIIVLDRT
QVEEESIFLEEAKDIDVALITGGDPLIATTHSDFLVECARKGIDFEVIHGSSILSSAPAI
SGLQAYKFGKVTTIPFPDLEYNYFPKSPYIAIEENLKMDMHTLVLLDIQAHKDKYMTVNE
GLENLMTIKDNLDHEGLVNEDSLAIGIARVGSKENLVKAGYIKDLIDFDFGGPLHCIVIP
SKLHIVEAEYLVEVAGAPREILDDI
>D3SQJ3|diphthine synthase|EC 2.1.1.98|Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3)|TrEMBL
MLTFIGLGLYDDRSITVEGQEALRSADRVYAEFYTSKLIGATVEELESAHEIEIEVRDRA
GVEQHPEDMLDAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIDTHVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDENRADGLHTVVYLDIKVGHERTDED
EYMTADVGADLLAEEYPDLVGVVVARAGSPEPLVEAGTMTELADQEFGEPLHLLVVPGDC
HLLEADALVELADADRETLDIV
>A0A6V8DJI8|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MSFSRTITSCTDLFGTLRCRITFIMGNGSARFTMTAVLEGPGLWLIGLGPGDLRHMTSFA
LSVAEACDKRYLEGYTAILPDDQEEKLGDLVGDWDRAMRDDIENPDQIIRQAKNVMVGIM
VVGDPMQATTHIDLKIRCQESGVPFHVVPGLSATSLAVSLSGMQSYRFGRQVTIPFPYGD
YLPTSPLEIILKNYSSNLHTLVLLDLDPTGMGLAPPEPMVPKQAYEILKAMAERYGEYEE
EEYGSLSSSISDWNAILLSDIGTSGQRVVSGSLSGISEFEGGLIHCLILPTEFSGMEKEI
FESLKADM
>A0A497HXU8|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGRLIFIGTGLMGGDWITTRGIEAAREVDFLFAEFYTSYIGDEGVKRLENILGRRIVRLS
RDEVEMKERLFKYLEDGDVGLLVGGDPMAATTHVELRLEAERRGHRTDVVYGVSIFSAAP
SSVGLQHYKFGRVVSVPWVSEKFMPRSVLEGIEGNLRCGLHTLLLLDLKDGEGFMSVNEC
LRTLLKLEERHEMGVVNEETLVVGAARIGDPTECIKGGALSEMLEENFGPPLHVVVIPGR
LHFVEEEALRTIAGVRDDVLERWKNKIESFCPKGPTPS
>A0A2H9NEP0|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum sp. CG_4_8_14_3_um_filter_33_2054|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>D9Q0I3|diphthine synthase|EC 2.1.1.98|Acidilobus saccharovorans (strain DSM 16705 / JCM 18335 / VKM B-2471 / 345-15)|TrEMBL
MLILVGSGLRESQLTREAEEAIKGADIVIVETYTMPSSKWLPTAVRKLNSNVREASRSEL
EELSSNIVELAFKLKVVLVVPGDPLIATTHSSLVVEGLKRGVEVKVVSGISGPCSVESLL
GLHFYKFGRTVTVPGPWRGVGAEEAALGLLGNLCHDLHTLLLLDVSPEGLSLSPSRAVKE
LKESLRRLIGTKLDELMNMMVLLVSVGENTIVKHFTLGNADSIPDVDVGSLVVPSRLHVS
EREFLRYAYSVPEDIMMSHNKLLQGFDACSAYSEALRVMYSSSA
>A0A0U3QV14|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 2319x1|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTDIKKIEGQIGKPIRLLNR
EDVELNFEKIVLSEAKTKDVAFLTAGDPMVATTHADLRIRAKQMGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKENKERGLHTLLFLDIKAAEGKYMTANE
AMEILLQVEEKKKDGVFTEDTLVVVLARAGSLNPTLKAGYVRYMIKEDFGKQPHVLIVPG
RLHIVEAEYLVAFANAPEEILKEV
>A0A3A5W5K1|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MMLAPSKRRGGLSMTAKRTTTTPLPATGLLLIGMGPGQLEGMSLEAIEAATRADVRRYEA
YTALWPQTELDALEEEIGPIEKVMRPEVEQPEALFKMANESLVALLVVGDPLQATTHVDL
QLQAAEAGIECHVIHGISITTLVTGAVGLSNYKFGRQTTLTYPYGGWVATSPLEVIAVNR
YQNLHTLALLDLDPTGEGVGHQVPMKPEDAVTSLRLMWKKLEEGLGEMPQETALEAMRFE
ACSSLLQTSLDGCVVVLCADMGTGEQQLSTTTVGELSALAGGRLNSLIFPSQPSEVEEKA
LLRWK
>A0A832Y2Z9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPSASQSAFRKKTSTDSTSRLGTLRWRITLMMGRRAPRFTMTDGALPAGLWLIGLGPGDL
GLMTSQAIEHARACEHRFLEGYTATLPTDQETLLENLIGPWQRAMRPTIEEPSEILALAR
DTSVAILVVGDPMQATTHIDLEAHCDEQSIDFSVIPGLSATSLAVSLSGLQSYRFGRQVT
LPFAYGDYLATSPLELIDANYTNNLHTLVLFDLDPTGMGVDEPQPMQAAAAVELLSRMVD
RLAEREGSTRESLAAPIAKWDGILMSDLGTPDQRVVSGDLEELAKVEGGRMHCLVLPADF
AGLEREAYERRRGQS
>A0A6V8DPE1|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTAEHNIITGLPTTGLLLIGMGPGRLSAMSLEAVEAAKAADVRRYEAYTALWPRSELDAL
EAAVGSIEKVMRPEVEQPDVLFELARTSLVALLVVGDPLQATTHVDLQLQAAEAGIECRV
FHGVSITTLVTGAVGLSNYKFGRQTTLTYPYGGWVATSPLEVIAVNMHQNLHTLALLDLD
PTGEGVGHQVPMKPSDALVSLRLMWNKLGEMLDDLPRETALEAMRHEACAVFLARSLDDV
HVVLCADMGTDDERMVATTVGALDSIEGGRLNSLVFQSTASEVEERALLRWE
>W8P4L6|diphthine synthase|EC 2.1.1.98|Thermococcus nautili|TrEMBL
MALYFIGLGLYDEKDITLKGLETARKCEKVFAEFYTSLLAGTTIDKVEELIGKPIVRLSR
EDVELNFEKIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTLLFLDIKAEQNRYMTANE
AMEILLQVEEMKGEGVFTPETLVVVLARAGSLNPTIRAGYVKDMINEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEEILKEV
>A0A7J3KF58|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLISLGIFDEKDMSIRAIECAKKCDFLFFERYTAKPKTDAKKLSEFLGKEVKEIKRED
IEENSEDIIKLSEKNNVGIIVSGDALVATTHISLIVEARKRGIETKVIHSSSIYTAVCSS
GLQIYKFGRTVTLTKRGEKSIIKEIKENKKRGLHSLILLDIDMELEDAINILLKNKAIKE
NEKIVLYSNIGEDEIIKYISPKEFFESDFRNFKEYQYSIIIPGKLHFMEEEYLSLLK
>A0A7T5R9R0|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGVGLHDERDITLKGLETMQACERICIELYTSKWKGKEALEERLRKTITELKRGDM
EEGMGKLLEDSRTRDVAVLVPGDPLVATTHVALFLEAKRLGVDVRVIHAPSVISAVASTG
LSIYKFGKTCTLPRPQEGFAPLSFYDVILENLRVGAHTLCLLDVGDRPMTVKEAVELLEA
AEKEKRKGMIGETRKAVAASFGETDVISYATLAELKRTAMPTPAVLIIPAELNDIEREML
ENKAF
>A0A8J8DYV5|diphthine synthase|EC 2.1.1.98|Thermococcus sp. GR6|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELQFERIVLSEAKDKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAI
AITGLQVYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQNRYMTANK
AMEILLQVEEMKGEGVFTPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGRQPHVMVVPG
RLHIVEAEYLVTFAGAPRKILDEV
>A0A2H9NGI4|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon CG_4_8_14_3_um_filter_37_24|TrEMBL
MLNLMGLGLSDEKGLTLEGLETLKKSDKVYIELYTSKWFGSIENLEKMTGKKIMQLKRPD
LEENLEKILKEAKNQTISILIFGDPLVATTHTALLIEAKKLGIKTRVIHNASIYSAAGET
GLHLYKFGATVTIPFLEKMNNQFPESLSKIIRDNKGRDLHTLCLLDLISEKEKYMTPSEG
MEVLLKSDDITQEDEIVIFGRAGSEEPLIAYGKIKNLIDKDFGNPPFVLIILGKLHFTEK
EYLEYHRAD
>A0A2H1EH37|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotalea sinensis|TrEMBL
MLWFVGLGISGLEGASTSTIQVLKKADMTFFEVFTSPISKQEISKIKKLVKGKLTIAPRW
MVEDGKVILELAKKKNVVLLAYGDPYVATTHLELRTRAEQDKIKTRTIHAASAITSLIGE
CGLHHYKIGRPVTIMRELPSLATVYYTIYENMVKGSHSLLILEFDNSSNFFLDPRDAISN
LLETEKGQKRNVIDQSTFAIVASRIGSKSQKIISGKLGTLVKTDFGKPPHTIIIPGRLHF
TEHDAIKIFSTCLDEPFDNSSKIVKISDQMLSRYIPKARGALEEVVKMFKDDKTLSPVIE
NAQLYIDDAEKFQKEGKEELAVLSIGYAEGLIDALRLSRGIDPWAQSL
>A0A1I1EKE5|diphthine synthase|EC 2.1.1.98|Halobiforma haloterrestris|TrEMBL
MLTFIGLGLYDERSITVEGREALRNADRVYAEFYTSELIGTTIEDLEAHHGVEIEVRDRA
GVEQEPDDVLEAAASEDVAFLTAGDTMISTTHVDLRLRARDRGIETRVIHGITAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPGSVTDTLEANREDGLHTVVYLDIKVGHELTDDD
EYMTADVGADLLSEEYPDTVGVVVARAGSPDPLVEAGTMTELADREFGDPLHLLVVPGDC
HPLEADALVELAGADREDLEIA
>A0A2I0Q0T1|diphthine synthase|EC 2.1.1.98|Methanobacteriales archaeon HGW-Methanobacteriales-2|TrEMBL
MLYLVGLGLYDEKDISLNGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINILRRE
EVEEDNLPIKQAENNDVAFLTAGDPLMATTHSDILMEARRNGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEQNYFPHSPYHVIGENKKMGLHTLVLLDIQAHRDYYMTANEGL
EYLLRVEEERREEIIEEDTLAVVIARAGSPEPLVRADRVDKLTEEDFGGPLHCIMIPGDL
HFLEAEGLVVLGNAPEFILEED
>A0A8J7YI25|diphthine synthase|EC 2.1.1.98|Halomicroarcula salinisoli|TrEMBL
MLTFVGLGLYDERSVTIEGRDAISDADRVFAEFYTSRLVGTDLETLEAFHDTDIEVRDRA
GVEQDPEPVLDAAQGDNVVFLTAGDTMVSTTHTDLRIRAEERGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEKAHGGDGVPDSVVATIEDNRARDLHTLVYLDIKVDDPHWAES
DDTYMTADQAAELLAAEFPDQLAVVVARAGSPDPLVAADTLSALAKRDFGDPLHLLVIPA
QLHPIEDEALSAIADD
>A0A7C2XQU4|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGVDSISVSTQKLLKQADIVYMEQFTSPISKSDTAKIKKLAKSKLKIAKRW
MVEDGTEILKNAKKKKVVLLAYGDPYIATTHIELRVRAIQEKIKTQTVHAASSLTSLVGE
AGLHYYKIGKIVTIMSELKSMTTPYYVIYKNLIEGNHTLLLLEYNQDAEFFLEPKNALNA
LLETEKEQKRKVIHPSTFVIVASRIGFKNQEITSGKISTLKKIDFGKPPHTIIIPGKLHF
TESDAIKVLTKCHDDLFDNSKTIKKIPKQMIEKYVPMVRQALREITPYFKDSKEFQEVLE
NAELYIQDAEKFLEQGKDEVAILSIGYADGLVDSLRMAKGLEPKM
>A0A1D2WIJ0|diphthine synthase|EC 2.1.1.98|Methanosphaera sp. A6|TrEMBL
MLYFIGLGLFSEDDISYKGFKALKSVDCIYAEFYTAKLMGGNIDNLIEKLDVPFITLKRE
DVEDANVIIKEAMTKDIAFVTAGDSLMATTHTELYVEAINKGIKTQIIHGSSIFSAAPGI
SGLQAYKFGKTTTVPFPDENFFPHSPYDAIKLNSQMGLHTLVLLDIQAHKDRYMTVNQAL
DYLSKVESERKEHVFDDDRIVIGIAQAGSKHPIVKGGRVSDVKNFDFGKPLHCIIVPANL
HFIEAEALITLADVDKELLKDFL
>A0A2A2FHZ0|diphthine synthase|EC 2.1.1.98|Halorubrum salipaludis|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSKLVGATVDDLEAYHDAAIEVRSRG
GVERDPEAILAAAEEGHVAFLTAGDTMISTTHTDLRLRAEDRGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVIDTIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWEDALAVVVARAGSPDSVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALAGLAGAPADLVEE
>A0A315XLA1|diphthine synthase|EC 2.1.1.98|Methanobrevibacter thaueri|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFEAIEELVGQEIEVLVRG
EVEEEHKFIEEAKTSDVALVTGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEAIEENLKMDLHTLVLLDIQAHKDRYMTVNQGL
EYLMNIKNDLDREGLITEDTLAMGIARVGSNDVVVRAGRISELIDFDFGGPLHCIIIPSK
LHIVEAEYLVEIAGADESILDDV
>A0A0M0BZ73|diphthine synthase|EC 2.1.1.98|miscellaneous Crenarchaeota group-1 archaeon SG8-32-1|TrEMBL
MVFVGLGLFDEKDISLRGLEELKEADTVFVEFYTSLMPGFCIRKLEENIKKEIIVVSRNM
LEEEDGQQLFEAAKKGKVVFLVQGDPLIATTHVDLRISAVKRGIKTRVIHGASVVSAVRG
ISGLQNYKFGKSVTIPFSEEGFISETPYNVIRDNKKMGLHTMCYLDIKAEEKKYLTINEA
LNILLTIEKQKKEQVITAKTLVVGVARAGSQQPVIKAGYVEEIKNYDFGEPPHTLIFSGR
LHFMEAEALITLANAPQNVKEQVE
>A0A218P5D3|diphthine synthase|EC 2.1.1.98|Thermococcus pacificus|TrEMBL
MAIYFIGLGLYDERDITLKGLEIARKCDTVFAEFYTSLLAGTTMDKIEELIGKPIRRLSR
EDVELNFEKIVLSEAKDKDVAFLTAGDPMVATTHSDLRIRAKQNGIESYVIHAPSIYSAI
AITGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENMERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGQGVFTPDTLVVVLARAGSLNPTLRAGYVKDMINEDFGKQPHVMVVPG
RLHIVEAEYLVEFAGAPREILEET
>A0A6G2J5D1|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0667_bin_13|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A345EFD9|diphthine synthase|EC 2.1.1.98|Haloplanus rubicundus|TrEMBL
MLTFVGLGLYDERSITVEGRDALRAADRVFAEFYTSRLVGTSVDALEAHHDVDIEVRDRA
GVEQRPEPILDAAEDESVVFLTAGDTMISTTHVDLRLRAMERGIDTRVIHGVSAAQAASG
LTGLQNYRFGKAVTLPFPRAHGGDGVPASVVESVAANRERGLHTLVYLDIKIDDGRGTEA
GETYMTADVAAGLLAEEWPDRLAVAVARAGSPDPVVVADRLSALADREFGDPLHLLVLPG
DLHHVEADALRTLGGAPADLLPE
>A0A7D6BVC1|diphthine synthase|EC 2.1.1.98|Candidatus Fermentimicrarchaeum limneticum|TrEMBL
MGTLIFIGMGIWNENDISVRGLKELVDSDVIFAEQYTGRMQEGSIERLEDAAGKKITVLS
REEVEEEKTILKEAESKRVALLVPGDPLISTTHISLKLSAEKKGIETVVVHSSSILTAAI
GECGLQVYKLGKPCTLAMWGKGFEPTSSYDVIADNFGRGLHSVVFLDLKDRCMDAKEAIE
QLLKIESERHRLGEFKLVVLSRVGSGEQKITYGRPDELLKTSLGKPPFLLVLPGKLHFME
EEALQRFEI
>H2C8H4|diphthine synthase|EC 2.1.1.98|Metallosphaera yellowstonensis MK1|TrEMBL
MSAIHFIGLGLSKRFLTNAALQTLRNCDVIYFDFYTSLSCDLSPESLAEITGKKVVSATR
DLLERREREILLHLENGKDVCIATVGDPMIATTHVSLFTEAVRRGHEAKVIPGLSVHCYA
ISRSMLSSYKFGKSVTITFPVSGKLDFTPYNVIKQNRDRGLHTIVYLDLKEDMVMTAQLA
ISYLLKMEDELKERVISEDDLVVIGERLGCQDERMRALRMSEALATDFGKPPHIIIIPAR
NLYDMEVEALKCLS
>A0A849Q3V2|diphthine synthase|EC 2.1.1.98|Nanohaloarchaea archaeon|TrEMBL
MLYLIGLGISDEKDISLRGIDACKSAKKVYIELYTCPLEIDISNLETIIGKKIEVLDRRG
VEESSKIINSAVVKDTVLLVGGDPLSATTHTGLILDAREKGIDAEIIHSSSIFTAVAECG
LSLYKFGKVVSLPKPQDNYFPTSPYDNICDNLQSGAHTLLLLDIGMSANDAISVLGELED
KKGSKILLSETKIVVCAHLGKKSNIAYGTLKELRDVDFSKHPHCIIIPAKLNFSEEEYVN
TFKKI
>C6A0P7|diphthine synthase|EC 2.1.1.98|Thermococcus sibiricus (strain DSM 12597 / MM 739)|TrEMBL
MVIKMSIYFIGLGLYDEKDITLKGLEIAKNCDLVFAEFYTSLLAGTTIEKIEQQIGKPIK
LLSREDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSI
YSAISITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYM
TANEAMNILLQVEEMKKEEIFTEDTLVVILARAGSLTPTLKAGYVREMIKEDFGKQPHIL
IVPGKLHIVEAEYLVEFANAPKEILKEV
>A0A1H8P977|diphthine synthase|EC 2.1.1.98|Halogranum amylolyticum|TrEMBL
MLTFIGLGLYDERSITVEGRDALRAADRAFAEFYTSKLIGTTVEELSEHHGVDIEVRDRA
GTEQDPTPILDAAEEEDVVFLTAGDTMISTTHVDLRLRAVERGIETRVVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGGDDVPQSVIDSVEANLERGLHTLVYLDIKAHREEYMTA
STAAEMLADGWEDQLAVVVARAGSPDPFVAADRLSALADREFGDPLHMLVIPGDLHHVEA
EALETLGGCPAELLDPL
>A0A7C5P0S7|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon|TrEMBL
MLTFIGLGLYDELDVSLRGLEAIRSADKVYAEFYTSRLTGTKIEQLEELYAKKIHLLDRE
DVEGSPEWIKDAIDHEIVFLTGGDAMVSTTHIDLRLRAEKLGVRTEIIHGASIISAICGI
TGLQNYRFGRSTTIPHPYTTRSGKTSVSHTPYDTIKQNQESDLHTLIFLDIDREKGCMSI
KQGIKLLMQVENERNEEVISDYTLGVGVARAGSAREMVRADYLRELERLDFGRPLHTLSI
PASLHPIEAEALVAFTDAPKEILHNI
>A0A315XI41|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVKNADAVYVEFYTSTLIGTSLEKIERFYGKKLIVLSRE
EVELEPIWLSRSIKENVVFLSGGDAMVATTHIDLRLRAKDMGVKTMIIHAPSISSAVSGL
SGLSNYRFGKSTTIPFPYTRNDKMIISEAPYDTIKMNKKNDLHTIVFLDIDREKGFMDIK
KAASLLLEMEGRRGEGMLVNALGVGIARAGSSSPAVHSDYIERLKDHDFGGPLHILLIPA
SLHFMEAEALVKFCGAPPEILK
>A0A1H6FZ04|diphthine synthase|EC 2.1.1.98|Natronorubrum sediminis|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSKLIGTTVADLESNHGVDIEVRDRA
GVEQHPEDILEQAETEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGITAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDDNREDGLHTVVYLDIKVGYDPTRSQ
HATRADDKVGDERADEDEYMTADIGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMSDLA
TREFGDPLHLLVVPGECHLLEADAVVELAGADRSTLDVV
>A0A7Z8KNU6|diphthine synthase|EC 2.1.1.98|Methanolobus vulcani|TrEMBL
MLTFIGLGLFDEKDISLKGLEAIKNADMVFAEFYTSRLMGSSLEEMESLYGKKVNLLYRE
DVEISPDWLAEAKDKNVAFLTGGDTMVSTTHVDLRLRAKNLGIETKLIHGSSIASAICGL
SCLQNYRFGKASTIPHPYTSSRGITVISETPYDTIKLNKEHNMHTLVFLDIDKDKGYMTI
NQALSLLLQVEEKRGEGVMENAIAVGIARAGSEAPVVKAGYAHDLKEDDFGEPLHILVIP
ASLHFIEAEALVELLGAPAEILEGLDD
>F6D1U9|diphthine synthase|EC 2.1.1.98|Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)|TrEMBL
MLYFIGLGLYDEKDVSIKGAEALKEADAIYAEFYTARLFGTSISALEDMLSVKITILTRE
EVEEENIPLKEAETKNVAFLSAGDTLIATTHSDLLIEARKMGIETTVIHSSSILSAAPGI
IGLQAYKFGKVTTIPFPEENYFPHSPYLAIKANMESKLHTLVLLDIRAHEDRYMTANQGL
EYLMKVEDERNENILSEDSIAVVIARAGAQKPVVRADKIKNLLHEDFGGPLHCLIIPSDL
HFMEAEALVVLGGAPQEILENDL
>A0A550H7W8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MISLVSIGINSHLDLSIRAIETAKHSDKIYAETYTMKLETNLEELERIITKPITLLKRNG
LEEQADQILKEGKKYHISILVGGDALSATTHISLLLDAKDEGIETEVIHGSSIFTAITDT
GLSLYKFGKTVTIPLIEKGPVDTVIQTIKENYENGLHTLLLLDLNIPENKYLTIPQAITR
LLDTRELSSDTLLVGAARLGSIDPTIKADTAQNLQKYDFGEPPHALVAPGKLHFMEEEAL
EILAGCPRRVIQNHNPVGETDKLITKYTTGCRKVLEQLKTNKLPASITAEQVMELLKHTE
NYLDDAEYYRTDKKPTALTSVAYAEGILDALKLLGIAEFEW
>A0A537GNE9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLTFIGLGLNDEKGITLEGLEEARRADSVYGEFYTNIMPNLDLKRLEKEIGKKVEVLDR
SQLEDEGGKKVLTAASTKRVAFLVPGDPLIATTHISLRLSLAKMGI
>A0A7C5MFR0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLKFIGLGLYDEKGLSILGLEEAKNSDVVFAEFYTSFMPGLSLNRLENLIGKPIQILSRK
DVEEKGEEIILKVAKEKDVAFLTPGDPMNATTHIALRIKAEKMGIKTKLIHAASIFSAIA
GATGLQSYKFGRSVSIPIANKFPISETPYNVIKINKNLGLHTLVLLDLDVEAGVYLTVPE
ALKQLLIVEEYRKENVVNLDSFIIVAARLGGATMEVKSLLIKDALNQDFGKPPFSIVFPG
KLHFMEAEALQVLTGAKKEFLKGNL
>A0A7C7UKD2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGKLIFIGLGLRGLGGISLEGLEKAREADRVYLELYTSPMADFSMEELGRLLGKSPILLK
RADLEDEDGKKVLETAKEGCAVFMVPGDPLIATTHVDLRLRALKAGIKVEVVHAASIYSA
ASSIAGLQIYKFGKTVTIPFPTPSYTPETPYEVLKENLSRGLHTLLLLDYDAEKDRWMTV
KEGLQYLLSLEEKLRERVAGPERLALGLAGVGRVDVEIRGGAIGRLIKA
>A0A537F9P5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVVTFIGLGLNDERGLTIEGLEEARRSSNVFAEFYTNIMPGLDRKKLELLLGERIVELSR
VQLEDEGGKQIVEAVERGRVAFLVPGDPMIATTHISIRLELAKKGVPSRIIHGPSITSAV
CGATGLQSYKFGKSVTLPHESGVPASVLDTLHDNGKRGLHTLMLLDVRPEQSKQLTIGEA
AAKLVVADPRLQRSLGVGVARIGSDDQFVLSRRLETLQHQEFGKVPHSLVVPGKLHFMEA
ESLKAFCGASDEDLESLK
>A0A7J3BEP7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRYECSWRVDVQKLPCLILVGLGLHDECGLTLRGLKSARDADHIFIETYTNYMPDMSFSN
LSNILGKEPIKLIRKDLEEDSGRILEYAKKSKVAVLVPGDPLIATTHVQLAVEAKKLGIE
VAVVPGVSILSAAISQSGLQSYKFGKSVTLPFARGRQFFETPFEVVRENKAKGLHTLMYL
DVDCEGRSMSIGEALALIMNWEETERKGVFLPSTLVVGLARIGSDHPVVKAGSIEELRTY
PFGPPPHILIFPGRLHFMEREALRYLAGASEESLESISWAKK
>A0A550HGH8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKISNNLFFGPIEYLNSQSFFQILIIRLIFCDDPLLKENNLTELTLIGLGLHDEKGISLQ
GLEKAKRATYVFAEFYTNYMPAIKISNLEKLIGKQVKILSRKEVEDHAQEKILVYAKKYP
CVFLTPGDPNIATTHIDLRLRAENKGIRTSIIHSASISSAIAGATGLQNYKFGRTVTIPF
KSTSISEIPYENIFENKSRGLHTLALLDINSESHLFMSIPDGLTIIIEIEERLGKRCATK
NTLAIGVARLGSPDASVKADTIEELQRFNWGGPPHCIVFPGKLHFMEVEALKILCKADPE
LFEI
>A0A497N9V3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MEVCRREVPLGELIFVGLGLFDEGDISLKGLEAVRGADQVYIELYTSLMGGFSIGRFERF
IGRKVTSVSRRVLEDEGGKVILEGAERGRVVLLVPGDPLIATTHIDLRIRAEKRGIRTRI
IHGASILSAAIGLSGLQNYRFGKSVTIPFPYKGRISETPYDVIKENKARELHTLCFLDIR
AEEERFMTISEALRILLNLEEKRGEETLTDESLAVGIARAGSKDVRVKASYVKELLQYNF
GPAPHTLIIPSERLHFMEAEALINLAGAPEEVRGMVR
>A0A075HV17|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_82_C03|TrEMBL
MLWFVGLGVSGGESIPVEVVKVIQNADMVYLESFTSPIYKHNEEKIKSLTNGNFKIAKRW
LVEDGQEILRTAKVSNVVLLSYGDPYIATTHIELRTRARLEKIETKTIHSASAITSMVGE
TGLQFYKIGRIVTIMNEKKSLLTPYTTIFKNLLQGLHTILLLEYNEVENYFLDPKNAISD
LLEVEKEQKRNVVNENTFAVVASRIGLKTQMITSGKFSNLLKINFGEPPHSIIITGKLHF
TESGAIRVLTECLDKPLDNSNEIKSISIQMIEKYVPMVREALEEIKPFYNNVKECQEILQ
NAELYVNDAENFLNQGKDENAILSIGYADGLVDALRIAKGIDPKM
>A0A2U9IGF9|diphthine synthase|EC 2.1.1.98|Acidianus brierleyi|TrEMBL
MSYLYLIGLGLSKKFFTNKALEALKQSDIIFLDYYTSFSCDLTKEFLEKITGKEITLASR
NMLENNSNEIMNLLDSGKNVAIASIGDPIIATTHVSIAVEANRKGHIVQVIPGISVHCYI
ISKSMLSSYKFGKSVTLVYPYDNIMDFTPYEVIKSNRALNLHTIVYLDIKDGKFMNAIEG
LKYLIEMENVKKENVISMDDIAIIGQRLGCDDEKISAVKLSDLENAKLRDPPHIIIIPSK
NLHYMEVEAIQCLH
>A0A101F4I5|diphthine synthase|EC 2.1.1.98|Methanosarcinales archeaon 56_1174|TrEMBL
MLTFVGLGLFDEHDITLKGLRAVQQADEVYAEFYTSRLCGASIEQLEALYGKKVHVLSRE
DIEGHPTFIERARELDVVLLSGGDPMVSTTHVDLRLRAHRMGIATRIVHAPSIVSAVCGL
TGLQNYRFGRSATVPFPYEHGERRMVYESPYDVVRENLERNLHTLLYMDIQNGRFMRASE
GAALLLEVAQRRGDEGLSSRLGVAIARAGSEDCVVRAAPLEDIASMELGPPLHVLVVPAE
LHFMEAEALVEFAKAPRHILEG
>I3ZV28|diphthine synthase|EC 2.1.1.98|Thermococcus cleftensis (strain DSM 27260 / KACC 17922 / CL1)|TrEMBL
MAIYFIGLGLYDERDITLKGLEAARKCDLVFAEFYTSLLAGTTLERIENLIGKPIRRLSR
EEVELHFERIVLSEAREKDVAFLTAGDPMVATTHADLRIRAKQLGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVILARAGSLSPTLRAGYVKDMLMEDFGRQPHVMVVPG
RLHIVEAEYLVEFAGAPKEILETV
>A0A534JGN2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELAFIGLGLFDEKDVTLKGLEVAKAADVVFAEFYTSALRGTTIPTLQLLVGKPIRVLT
RHDLEQGSEVLEAARIGNVALLIPGDPMAATTHVELRLRAHDAGIPTRIVHGPSIISAAA
GLLGLQSYKFGRATTVPFTSEAFRPGSPLDVIEENLERGLHTLILLDLKESGEFLTAREA
IRYLLGLAKSKGSVAFSEDTLICVLGHAGSDQPRSFSGRAGDLVVRDLGSPLHCIVVPGK
LHFLEAEALVKLAGAPSSLVAEGPGPKAPAGHGSRTRPRGRTSGPRASRRARP
>A0A7C2A5W0|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
KINFLKRKDVEEKDFIVEEAEKENIGFLVSGDPLAATTHIDLVLRAKKRNIDVKIIHASS
IFSAVSETGLQLYKFGKTVSIVYPEEKFFPKSFYDTIISNKERGLHTLLLLDIKAENERY
MDPNEAFEILETVDKNKIIKKVIVVSRLGRDDQRIIYGDINELKSCSYGDPPHCIILPGE
LHFLEEEFLNYFKVKK
>A0A7C6H1U1|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MSGKLIFVGLGLSRPQDMSVRAQQVLRECDEVFAEFYTSRLIDATMEDLEEFIGKKVAVL
RRSEVEEGDAIIEAARRGTVAFMVAGDPMSATTHVDLRLRAIEEGINTELVFGVSIFTAA
AGAFGLQPYKFGRAVTIPFPEPGYLPSSPYENILENRERGLHTLVLLDIREEESRYMTAA
EAVNWLMDAEERLQKGLLKEDTIICAGARIGSPNQRLLAGPPSLIASTDMGPPLHCLIVP
GRLHFMEARALVRLASAPESIMDDD
>A0A1V5ATP3|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaU1.Bin112|TrEMBL
MLRNDSQQRFKLKRRETAMLIFIGLGLYDERDISVKGLDAIRAADLVYAEFYTSRLMGAA
LETLEAFYGRRVHLLSRKQVEVDPAWMEDARDKDVAFLVGGDAMVSTTHLDLRLRAARMG
IRTRVIHSSSIVTAVSGLCGLQNYRFGRSTTIPFPYVSRGKRIIAQTPYEVLTENLDRNL
HTMLFLDIQIDSTERYMTVNEGVSLLMEMEDISGGKRLDGALAIGIARAGSDGATVKADL
LARLQGFDFGGPLHILIVPARLHFMEAQALAVLAGAPEDALKCVD
>A0A7K3YBU3|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLMFVGLGLYDLGDISVRGLEYVRSADAVYLEAYTSRLMGTDAAGMEAFFNKEIRVLGRE
DVEQTPHEIIERAARGRVAFLTGGDPMISTTHADLRMRAAAAGVATSIIHASSISSAVSG
LSGLQNYRFGKSCSIPFPAKGWFPTAPVETIAANLDRDLHTLVYLDIQESRCMSIREAID
ILEEMAGMRGIEPPALYVGIARAGSESPVVAAGSGAKLKEIDFGPPLHVILVPAGLHPME
REYLEIFAGL
>A0A522V9I0|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedens sp|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVRKSDIVYAEFYTSHLMGTTIDEMEKFFGKKITVLSRE
DVEQNSAWLSQGKKKNLVFLTGGDAMVATTHIDLRLRARDMGIDTAIIHAPSISSAVSGL
SGLQNYRFGKSTTIPFPYERKNKVIISEAPYDVIKMNKKNDLHTLVFLDIIEREKRFMDI
GTAISILLGLEERRGEGVLMNTLGVGIARAGSKSPVVHADYLPELKKHDFGAPLHTLIIP
ARLHFIEAEALVKLCGAPSEIMK
>A0A1V5A9W8|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon PtaU1.Bin222|TrEMBL
MLTFIGLGLYDHRDVSVKGLEYIRQASRVFLEGYTSHMKGTTLEEMQTFFGNAITLLTRE
DVEQNPGEILDAASRSNVAFLTGGDPMVSTTHADLRIRAKERGIETAIIHGASISSAVCG
LTGLQNYRFGKSCSLPFPAKNWFPITPIEVIQKNLEAGLHTLVYLDIQEDRCMTVPIAVD
LLEQMAQTAGISIPCYIGVARAGSMNPVVSAGTAEKVRATEFGPPLHILVVPGPLHVMER
EYLTIFGGL
>A0A497I2W4|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLYLIGMGIHDPRDMSVKGLEIAKRCEEVFYERYTSPVSVEGLRELLGKEVKELKRKDVE
ESNLLIEKAKEKDVAFLVPGDPLVATTHQELVLRARKKGIKVKIIHSSSIVSAVCETGLH
IYKFGRVTSIPKTREDFFPTSPYHILRENLERGLHTLFLIDPEISLEEAVGYLFEAEKKE
KRGVVSEETKGVSLSLGEEPEIVYGKLRDLKGRGKPQSLIIPGELHFTEEEFLRWWEHGE
EEKG
>A0A0B2ZYZ5|diphthine synthase|EC 2.1.1.98|Archaeon GW2011_AR4|TrEMBL
MTLYLIGIGLSDAQDITLKGLETIRKCHSVYLEGYTSLMSCSIDELEKVYGKKIVFLKRE
DVENEREKITLEARTHDVALLIIGDVFSATTHADIILDSRKKNVSVKVIFNASIMTAIGI
TGLQLYTFGKTVSIPYPSKGFAPDSFFEGFLENKQRGLHTLFLLDIKADEGRYMSVPEAI
ALMIAAAEKRKNNGFTKQTLCVGCARLGCGDMLIRSGTAEELLGMDFGKPPHCLIVPGDL
HFIEEEMLEIWKG
>A0A368TK97|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MKLSVSKRSEQIVLSEIRSMSIECDKVNGINLAQGVCDLEIHLLTLLRSKTVSFNKLFFY
KKKSLFMLTFVGLGLYDEEDLTLKGLEAIRNADVIYAEFYTSPLGGKTIEAMERMYGKRI
FVLERSDIEETAEGGILKLAKHQKVVLLSGGDAMIATTHLDLRLRAIDMGIETKIVHAPS
ISSAVAGLSGLQNYKFGKSITVSPAYKDVISEVPYETIIANRARGLHTLLYLDISMSIAE
ALKLLEAVEVNKNGNELKQTILVGIARAGSDNPVVKADYMNVLNSYEFGALPHVLIVPGN
LHFMEKEALIKIAHAPEDM
>A0A1I3LLC0|diphthine synthase|EC 2.1.1.98|Natronobacterium gregoryi|TrEMBL
MLTFVGLGLYDERSITVEGQQALRNADRVYAEFYTSKLIGTTVEDLEVHHGIEIEVRDRT
GVEQEPDEILEAAKEETVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPTSVTETIDANREDGLHTVVYLDIKVDHDRTEED
EYMTADLGAKLLAEEYPDLVGVVVARAGSPDPLVEADTMTELADRDFGDPLHLLVVPGEC
HLLEADALVELAGADRDALDVV
>A0A4P8WIB8|diphthine synthase|EC 2.1.1.98|Natrinema versiforme|TrEMBL
MLTFIGLGLYDESSITVEGRDALQAADRVYAEFYTSKLIGTTVDDLEAAHDIEIEVRDRA
GVEQEPDDMLAAAETEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNQDDGLHTVVYLDIKAEREEYMTA
DVGAELIAEEYPDLAGVVVARAGSPDPLVEAGTMAELADREFGDPLHLLVVPGECHLLEA
DALVELAGADRESLRIA
>U2YGW9|diphthine synthase|EC 2.1.1.98|Halarchaeum acidiphilum MH1-52-1|TrEMBL
MRRSATAVGRAQRNPYPRRFPTRRMLTFAGLGLYDERSVTVAGRDAIADADDGAVFAEFY
TSHLVGADVADLEASHGVEIDVRDRAGVEQDPEPILDAAASGDAVFLTAGDTMISTTHVD
LRLRAHERGIETRVIHAPTAESAASSLTGLQNYRFGKATTLPFEWAHGADVVPDSAIDTI
EDNRERGLHTLCYLDIKVGRGPAGPDPDFEAYMSADYAAGLLAEAWDPDALGVVVARAGS
PDSLVRADRLGALADGEFGDPLHMLIVPGDLHHVEADALRGLADAPADLVDGNRA
>A0A2R6EST3|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_7_66_36|TrEMBL
MLSFVGLGLWDERSVTVEGREILRNADRVFAEFYTSRLMGTDAASLAAHHGVEIEVRDRA
GVEQNPDPVLAAAEDGHAVFLTAGDTMISTTHVDLRLRAHERDIDTRVVHGTTASAAAAS
LTGLQNYRFGKATTLPFPYAHGGEGVPASVSDAIDTNRDRGLHTLVYLDIKQTRAEYMRA
DMAAGLLVDGYEDALGVAVCRAGSPDPRVEADRLSALAEGSFGDPLHLLVIPGDLHHVEA
DALRTLAGAPDDITEPR
>A0A0V8RUY0|diphthine synthase|EC 2.1.1.98|Pyrodictium occultum|TrEMBL
MPLYIVGAGVSSEYLTLRALQLIGAADKVYIDVYTSIAPGVDRELVRRLNPRAEIVEATR
RMLEDEAWRLVEEARERSVVLLVPGDPLHATTHVALLLEARRRGVEAHAVPGVSGLQAAV
DATGLQVYRFGKTVTLVYPEEGFKPYSTVETIWANQERGLHTLVLLDLRLDEGRAMAVPE
AVSILLELEKELARETGREPQIRSALLAGVARAGTSEQHCVAGTPEEVASASYPPPPHSL
VVTAPRLHPVEEEALRLLCGCRSCGRG
>A0A8J8E824|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 21S9|TrEMBL
MALYFIGLGLYDEKDITLKGLETARKCEKVFAEFYTSLLAGTTIDKVEELIGKPIVRLSR
EDVELNFEKIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTLLFLDIKAERNRYMTANE
AMEILLQVEEMKREGVFTPETLVVVLARAGSLNPRIRAGYVKDMINEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEEILKEV
>A0A7J3DIK3|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLALVGLGINIDPTIEGIETAKRCDEIFLEKYTSPIPIGIQGKLKKLIKKEIALLDREGV
ESDFLIDRAKNKNVCLLVVGDPLVATTHISLLAECRKRKIETKIVHNSSILTAVARTGLQ
LYKFGRTVTIAKWSENYKPTSPLLLIEKNLSIGLHTLVLLDVQPEPMDAREAIKQLFDME
RIEGKKIVKDVVVLSRLGFEDEKITYGDAEKLLERDLGKPPFSIVIPATLHPAEEEYLKF
FEV
>A0A662W786|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon|TrEMBL
MLIFIGTGIWDEMDISLRGLEAAKNADEVYAEFYTSKPATNAKKLSKLLGKEVRVLERSD
LEENSIEIVKKAREIDIAILIPGDPMIATTHAAIRVQAKQNGVETKIIHSSSIISAVCGI
TGLHNYRFGKSATISYPYGVISSFPAETVKINQKINAHTLLFLDLHPEPMKIDEAISILE
KSDRELLNLFAVGIARAGSEGCVVKCDRLKNLKKFEFGPPMHVLVILAPKIHITEFEYLK
EFANAPSELEAIVE
>A0A662VF75|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGKLYIVGLGLTPDLITLRGLRVLNKVKRIFLETYTNIILDGESLEDVLKGKEVIRVGRR
DLEDQSGKVILDSLAQGDVALIVPGDPLTATTHISLVMEALKRGYEVEVIPGVGIIPSAL
TLAGLMIYKLGKIITMVYPKEGIVYEYPYDVIKDNDSRNLHTLLLLELDAEKNIVMSIKD
AIHLLYELEERRGEGIIKPHRSAVAVVALGSKRQSICYGSLEELSIIDEKDVPQTLIITS
PKLHFVEEEMLRVINNVWCKYFK
>A0A662U9Q7|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MVWLAFVGLGLKLKHLTLEALEVLKDSDIVFLDSYTSVGEDITVKSLSSLLGKPIRQITR
HEIEEENGKIIFDALDKGLNVSFAVIGDPFIATTHIVLLLEAVKRGIEIRIVHGISIYSV
AISCSGLMAYKFGKTATVVYPKDNITFEYPYNVIKENKERELHTLLLLDLDAEKGVFMTA
NDALKILLSIEAKRKENVIKNNEKVLVIARASSKNQKCVYGPVRKLVTMDFSKPPHVIII
PGKLHFIEEEALRRFSIE
>A0A7J3T8K8|diphthine synthase|EC 2.1.1.98|Aciduliprofundum boonei|TrEMBL
GKLIFQAASEGNAVLLVAGDPMIATTHVALRIMAEERGIKTKIVHNSSIVTAAPGLLGLQ
QYKFGRTVSIPFPQENYFPTSAYDFIYENFSKGLHTLILLDLNPRPMTANEAIEILEEME
SRKKRGIIKENTLLCVVARAGSENPLIRADRLKKLKKEDFGPPLHTLVLPGKLHFAEAEA
LVKLAHAPQDITQ
>A0A5E4ISL8|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MFYLIGIGLWNEKSASLQAIEAIKKCETVFAETYTNRMEEGTILEISKLTGKKIVYLPRE
RVEEEKEIVAAAKKGDTALIVPGDAMMATTHVSLLLSCRKAGLETKVIHGTSIITAAIGA
AGLQIYKFGRTTTLVSWSEKYRPTSTYDAIRENFDRGLHTMVLLDIVEGKPMEAKQALEL
LLEMEKAKKGKVFSEKTEIVLLSRIGGEEQKVSFGEIGKLMKNVKGAKMGEPPFCIIVPG
KLHFLEQEFLAAFSS
>A0A0F7PE29|diphthine synthase|EC 2.1.1.98|Halanaeroarchaeum sulfurireducens|TrEMBL
MLTFIGLGLYDEHSITVAGQAALRDADAVFAEFYTSRLVGTSVDDLESYHDVTIEVRDRA
GVEREPDPILAAAREGDAAFLTAGDTMISTTHVDLRLRAHERGIETRVIHAPTAETAASS
LTGLQNYRFGKATTLPFPWAHGADGVPGSVIDTLEDNLDRGLHTLVYLDIKAAKEEYMNA
TTAADILRQHWNEDVLGVVVARAGSPDPVVRADSLLGLANEDFGDPLHLLIVPGDLHHVE
AEALRTLAGAPDALL
>M0IUK6|diphthine synthase|EC 2.1.1.98|Haloferax denitrificans ATCC 35960|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A075GY17|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_195_B03|TrEMBL
MLWFVGLGISGTQSIPIEVVKIIQKADFVYLESFTSPIYKQQEEEIKNMVNGSFKIAKRW
LVEDGQEILKASKSSTVVLLSYGDPYVATTHIELRTRAKLEKIETNTIHSASAITSMIGE
AGLQFYKVGRIVTIMNEKKSIITPYTAIFKNLIQGLHSVILLEYNQDENYFLDPKDAISS
LLDVEKEQKRNVVNNDTFAIVASRIGFETQKITSGKFSNLLKVDFGELPHSIIITGKLHF
TESDAINVLTECLDKPSDNSSRIKSTSIQMIEKYVPMVREALEEVKPFYNNAKEFQEILQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>G0HV83|diphthine synthase|EC 2.1.1.98|Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A371M0T9|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-4N|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILNAAEDDHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A0B3ANQ9|diphthine synthase|EC 2.1.1.98|Archaeon GW2011_AR18|TrEMBL
MLYIIGIGLGNEKDISINGLESVRSCDVVYLENYTSKLMFKIEDLEKLTGKKIILADREL
VESGEEILKNANEKNVALLVKGDVFSATTHTDLYLRAVKQGIKTRIIHNTSILTAIGDTG
LSLYKFGKTASIPYHYRNVKTPIEIYENNKEMHTLFLLDLNPKENKYINYKEGLKYLLEN
SQGKISPNNKVVICAALGTEEQIIKYGKINELLDIEINVYPQCIIIPGKLHFMEEEVLEL
YKIQ
>M0GD03|diphthine synthase|EC 2.1.1.98|Haloferax sp. ATCC BAA-644|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEASHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVGWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7J4I565|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MVLYLIGIGLSDEQDITLKGFEAIKKAEKVYLEYYTSRLQVEPAKLEAFYGKKIMVCNRE
LVEQRAEETILADAQHHDVAFLVIGDVMGATTHSDLILRAKEKKISVIIINNTSIINAIG
NTGLELYKFGKTISIVFPQKNYAPETCYDVIKQNQSIGAHTLCLLDIHTDEKQGTDVKCM
TINEGLQLLLNIEKKRKENVLSENTLVLGCARMGAGAHDQLIKAGTIKNLLNVNFGKTPH
CIVIPAKELHFKEEEMIGLWR
>A0A3M0XM63|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLIGLGLFDSKDVSLRGLEAIKSCSKVYLEGYTSRLSCPVEDLKKLYGLPVEVVGREF
VESADELLKRAGKEDVALLIIGDPLCATTHWDILTRARELGIDTRVVHNASVMSAIGATG
LQVYKFGKTTSIPFPQEGFEPENFYDILAQNKSIGAHTLMLLDLDPKSDKFMSVNEAIEL
VRKVERKHNKGIFLPEDLCIGVARLGWESQKIVSGTVLEVSDADFGPPPQALIVPGNLHF
VEEDAINSWRA
>A0A662FN07|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLILIGLGLGDHTDITLKGLERVKKADKVYLDEYTSRFEDSARDLENFYGKKVIRATRDI
LESERLVEEAKKENIVLLVVGDALSATTHIDLLMQAKKENIEVEVIHNASILTAIGTTGL
QLYKFGKTTSIPFWKDNYKPENFYEVLQQNKSIGAHTLMLLDITPERCMTIKEAIELLLK
TEEKRKEKIFDKTTLCIGCARIGSADQKIKAGTAEELMKEDFGEPLHCLIVPGELHFVEE
EAITFLR
>A0A6B1D0P3|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0661_bin_35|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A6B9T7N8|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccaceae archaeon DOK|TrEMBL
MTSELIFVGLGLSGTDGMTVKAFNALKECDKIYAEFYTSMLIGTKVEDLEAALGKRVHVL
YRAQVEECDDVIKDAMEMRVGFITAGDTMSATTHVDLRIQAAEAGIPVRVFHGISIFSAC
PTSLGLQHYKFGRTVTLPFLEENYHPKSPYDHIKENKDRGLHTMILLDIRADELRYMTAH
QAIEWLIEGEKAWGEGLIDDKTLLCVASQVGSPNEKVFAGYPQDLLKMDLGEPLHTLVLP
GNLHFMEAFALVRFAGAPEEIIEDE
>A0A166BLK4|diphthine synthase|EC 2.1.1.98|Methanobrevibacter oralis|TrEMBL
MFYLVGLGLFDEKDISLKGLEALRNVDKIYAEFFTSRLFGSNFDKIEELVGQKIEVLIRS
EVEEESKFIDEALNSDIALITGGDPLIATTHSDFLVQCAKRGINYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEVIEENLAMNLHTLVLLDIQAHKDRYMTINEGL
EYLMNIKDKLDHEGAIVEDTLAIGIARVGSKDVVVKAGYIKDLIDYDFGGPLHCIVIPAT
LHIVEAEYLVEIADASPDILE
>A0A643K2I0|diphthine synthase|EC 2.1.1.98|Haloferax sp. CBA1150|TrEMBL
MLTFIGLGLFDERSITVEGREALAAADRAFAEFYTSHLVGASVEDLESYHDIDIEVRDRA
GVEQDPEPILDAAAEENVVFLTAGDTMVSTTHVDLRLRAEERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVESLEANRERGLHTLVYLDIKVDWEGRRGV
EVDGDEYMSADYAAELFAEHWDGDALGVAVCRAGSPNPVVAADRLGELATRDFGDPLHML
IIPGEVHHVEADALMALGNAPAELFDLDDR
>A0A662LF93|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLIFIGLGLWDEKDITLKGLEEAKNCDKIYAEFYTSKMGVGIEKIEKLIGRKIEVLSREE
VEDGKKLLEEAKEKRICLLTAGDPMTATTHVELRLRAIENGIKTKVIHGISIVSASAGLA
GLQIYKFGKIVSIVKPSKNYFPLSPYDTIKENLNMGMHTLLLLDITNDCMTANEAMEILL
EMEKRKKEGIIKDDTLIVVLARVSSDDALVRAGYIKDLINEDFGKTPHCMILPGKLHFME
AKALVILGNAPPEIMDLFHN
>A0A843FZI2|diphthine synthase|EC 2.1.1.98|Methanomicrobium sp|TrEMBL
MLTFIGLGLYDERDISVKGLEIIKSADKVYLEGYTSRLMGADVRKLEEFYGKSVTLLNRD
DVERFPGKILDAAAEGDAVFLTGGDPMVSTTHADIRIRAEERGIATRIIHGASIQSAVCG
LSGLQNYRFGKSCSVPYPERNWFPTTPLDTILSNFRQDLHTLVFLDIKPDRHMSVPEGVE
LICRMADKCGETAPPLYVGMARAGSESPSVFAGSAEDVMNHDYGVPLHIIAVPASLHEME
REYLEIFAGLKRE
>A0A7U3D0J8|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLNIVGLGLQGLNSITIGGADAIRSSDEVYLDSYTSVLQPDSLKEISEYFDRKIIPVERD
FIEGPSPILDMCRTRNISLLVVGDGMSATTHKILEQNCASSGVKVRVYENASILNVIPWR
LGLYAYKMGPPVSLPFLSGSFFPTSVFSKIIRNHSNGMHTIVLLDLKSGQTIDILQALEW
LQEMEKRAGGDSILSKEEICVASRVRQPGEKIIYGSIEKLKTMHFGSPSSIVIPSNPDTF
EKENLAPFRASNEN
>A0A2H9HZZ8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon B24-2|TrEMBL
MLLLEGSYLGELAFIGMGLYDEKDISLRGMEELRVADKVFVELYTSHMAGLSIANLERLC
GKPVTVVSRREVEEEEGKRIIEASRDGRVAFLVPGEPMVATTHVALRIKAEKEGIKTRII
HSSSIISAAISLSGLQSYKFGRNVTIPFPEERVFSEVPYQVIAQNRSLGLHTLCLLDVLV
EKGRFMTVSEGLTYLLELERIKKGAVLNEDTLAVGIARAGSPNPEVHADSIEKLRRWDFG
PPPHSIVIPGNLHFMEAEALITLAGAPVEVTNRLVQDRKHGE
>A0A2G9MX13|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon CG11_big_fil_rev_8_21_14_0_20_47_5|TrEMBL
MLYLIGIGIGNEKGLTLEGAEALKKCKIVFLEDYTNLVEKETVTGIEKIAGRKVEILGRE
AVEGEKKILQAAEKEKTALLVSGDPLIATTHVSLVLSARKKGIWVKIIHASSILSCAIGE
SGLQAYKFGKSVTLAGWSRGYEPKDAYFVIEENKKRGLHTLVFLDIKEGKCMEAKEAVEL
LEETERRKKKGVIASETQMVAISSLGRKEQKISFGEIEKLKKAELGKSPSILIFPAKLHF
LEEEWLNYFKL
>A0A0F8CZF2|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 2.H.T.1A.8|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRRESVMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVNLAAGPEEIMEEME
>A0A498EQK3|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-105R|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7C4NG83|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLRCASLSLIFIGIGLTAKGLTIEGLSEAQKAEHVFIDAYTNLIPRNELHTLQNLIGKDI
KPLYRSDVEGRGVYELLKLTEKSTVALLVVGDPFIATTHIALRLEAIKRGVKVKYVPSAS
IASVIPGLTGLSSYKFGKSATIVFPDKGSNNAAYDAIKDNSSRGLHTLLYLDLEVENKRA
MTINEALKLLLDVEAQRAEGVVREDMLIVGIARACWNNEIVKAAKLSKLINYDFGPPPHV
LVVPGSLHFMEYEALKALAGMED
>A0A2H4VCZ5|diphthine synthase|EC 2.1.1.98|Methanobacterium subterraneum|TrEMBL
MLYLVGLGLYDEKDISLNGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINILRRE
EVEEDNLPIKQAENNDVAFLTAGDPLMATTHSDILMEARRNGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEQNYFPHSPYHVIGENKKMGLHTLVLLDIQAHRDYYMTANEGL
EYLLRVEEERREEIIEEDTLAVVIARAGSPEPLVRADRVDKLTEEDFGGPLHCIMIPGDL
HFLEAEGLVVLGNAPEFILEED
>A0A7J4HH60|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTSKDVSPGLWLIGIGPGDLDHITERAKSIARGCSKRYLEGYTAVLPSDQEERLEEVVGT
WKRLMRPSVESPKSLLDEAREEAVALLVVGDPMQATTHIDLEARCMEEGVGFEVVPGMSA
TALAVSLSGLQSYKFGRQVTLPYPYGEYLATSPLEMIETNRSSGLHTLVLLDLDPTGMGF
DLPTPMRPEQAVSILDRMAERVNEERDISNPTTVREWDGILLSDVGTSRQRVSSGSLNDV
SKLEGGYVHTLIIPSNMSDNEKDAFRRRNMS
>A0A238UNK2|diphthine synthase|EC 2.1.1.98|Halorubrum vacuolatum|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADSVFAEFYTSRLVGADVTDLERHHDVRIEVRSRE
GVERDPEAILSAAETGDAAFLTAGDTMISTTHTDLRMRAEARGIETRVIHGVTAQTAAAG
LTGLQNYRFGKAVTLPFPYAHGGDGVPASVIDAIEANRERGLHTLVYLDIKVGMGPKGPD
PEHEEYMPADNAAELLAAGWEDVLAVVVARAGSPEPLVAADTLSALATRSFGDPLHLLVI
PGDLHHVEAEALAGLAGAPEYLLPT
>A0A822IUW6|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVKNADAVYAEFYTSHLIGTSIEKIEKFYGKKLIVLSRE
EVELEPVLLSRAIKENVVFLSGGDAMVATTHVDLRLRAKDLGIKTYIIHAPSIYSAVSGL
SGLQNYRFGKSTTIPFPFTRKEKTIISEAPYDTIKMNKKNDLHTIVFLDIDQEKGFMDIR
KAVSLLLEMEERRGEGVLLNALAIGIARAGSPTPTVHSDYLENIKEYDFGGPLHTLIIPA
SLHFIEAEALVKLCGAPPEILQ
>A0A533WQW3|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGLGISGIDGISSNALNIIKKADIVFLENFTSPIGKQEVSKIRKIAKKKLKIASRW
MVEDGKAILLASKGKTVVLLSYGDPYVATTHIELRTRAESEKIRTKTIHGASAITSLVGE
CGLHHYKIGKPVTIMRELLSLTTVYYTIYENMIKGSHSILILEYNNDANFFLDPKEAFSS
LLLTEDSEKRSVINESTFAIVASRIGTKNQGIIAGKLSSLMNTNFGKPPHTIIIPGKMHF
TEHDAIKVFAKCLDEPLDNSSKIQKISEQMLLKYIPKARKALEEVRRVFKDDKVLQPVIE
NAQLYLDDAEKFQSEGKDELAVLSVGYAEGLMDALRLSKGIDPWAQSL
>A0A2H9L8C6|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon CG08_land_8_20_14_0_20_49_17|TrEMBL
MSLLLLAGLGLDFGISDEKLKQIEKCKTIFLENYTNLVSKGEMGKLKTIFQKTKKGIIVL
GREQVENEKIILDAMANGDVALLVSGDPLIATTHHSLVLSAKKANHKTKIIHSSSIISAA
ISESMLQVYKFGKIVTIPFPRNGFDPTSPYENIGFNLKNGLHTLLLLDIDSEKGAMPPNE
AFEILEGWEKKLKKKVITEKTKLLVLSSIGKDDSKVVYGTIVQLRKLKFNNPPHCLILPA
KLHFMEEELLAFFCLNG
>A0A1I4EK94|diphthine synthase|EC 2.1.1.98|Halogranum rubrum|TrEMBL
MLTFIGLGLYDERSITVEGRDALRDADRAFAEFYTSKLIGTTVEDLSAHHGLDIEVRDRA
GTEQDPTPILDAAEEEDVVFLTAGDTMISTTHVDLRLRAVERDIETRVIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGGDDVPKSVVDSIEANLERGLHTLVYLDIKAHRDEYMTA
STAAEMFADGWEDRLAVVVARAGSPEPLVAADRFSALAEREFGDPLHMLVIPGDLHHVEA
EALETLGGCPSELLDPL
>A0A7M3W7H2|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MALALSKRFGGLSMAARDSESSAFPEKGLLLVGMGMGSLDGMTVEAQRAAKAADHRRYEA
YTALWPDDELNRLEEMAGPIQRVMRPEVEEPDELFALAKQSLVALLVVGDPLQATTHVDL
QLRAQDAGIDCRVVHGISITTVVTGAIGLSNYKFGRQTTLTYPYGDWIATSPLEVLAANW
EQNLHTLALLDLDPTGLGTGDQRPMRPKDAVQSMRLMWEKLQETADEPLSEEYVRLAFRQ
MATKLYLQQSFDDIPVVLCSDMGTSEQSMVTTTLGGLGDEQGGRLNCLVFPASTGEVEDK
ALLRWKKE
>A0A6V8CM16|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MAAKPGLLLVGIGMGDIHSMTTSALHAIQNADFRILEAYTAKWSDDDLMLLKEMVGEFDY
ALRPDIENPEKILARCRENSVAVMVIGDPMQATTHVDLLLRAEELDIPYKVYHGISITNL
ATGISGLSNYRFGRPTTLTYAYGDWIATSPLEVISVNLQLNLHTLVLFDLDPTGLGTGDM
QPMLPVDARKTMYKMSEKWREGYVEEIENSDDYSFNFKLHSMNQLPDDLGQLPVVVCTDL
GTTNQNLWRGLLGFIENAPVGNMHCMIIPSYLSEIEENALNKWAKE
>A0A7C3UD24|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLTLVGLGLHDEKDLSLRGIEAIKRAEKVYIELYTSKWFGDVKRLEEITGKEIKVIGRPD
LEENYERILEEAKEKNVVILVQGDPLVQTTHVALVLEAKKKRIDTEIVHNSSIISAIAET
GLHTQKFGPYVTIPFPEKTKGLIPELLVETIEENKKRGLHTLCLLDVAERCMSVKEALEI
LVKAKVLDESSEIVVCSKLGSKDAVIIYGKVEELREKEFDSPSVIIIPGSLHFTEKEYLY
FFRP
>A0A2R6KFI3|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_9_67_15|TrEMBL
MLTFVGLGLYDERSVTVAGRDAVRSADRVVAEFYTSRLAGATVEDLESYHDTEVEVRDRA
GVEQSPDDILDDATDSDVVFLTAGDTMISTTHTDLRLRAHDRGVDTRVVHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHAGDSLPESVFDAIDENRDRGLHTLIFLDIDAADDDYMRA
GEAAARLADAYEDVLGVVVARAGSPDPVVRADRLSALADESFGDPLHLLVVPGELHLMER
DALAALGSAPTGLLDELVA
>G7VD44|diphthine synthase|EC 2.1.1.98|Pyrobaculum ferrireducens|TrEMBL
MFFLVGVGPGPGYITEVAARIIREADCVFYEDYTGPLDVEGLRRVARSEPVRLTRRDLEE
ESGRKIFECLREGRRAVLVTAGDPALATAHSALVALARSRGYRAEVVPGVSIICAAFSVS
CLSIYKMGGVATVTYPRGGVYSTRPYELVEQNLKRGFHTLLLLDVREDGAFMPPRDAAAV
LMQLEERERRGVFTPALPVVVVYRLGWGGSALYTTLGDLATSGIEGPAVVIVPSQLSPVE
RECVEGLARRQAV
>A0A2V3JNZ3|diphthine synthase|EC 2.1.1.98|ANME-2 cluster archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGVRAIKDADMVFAEFYTSKMMGTTIERMESLYQTKITTLSRD
EIETDPAWLHHAIDRDVVLLSGGDPMVSTTHIDLRLRASDLGIATAIVHGPSIASAAAGL
AGLQNYRFGKSATIPFPYTVRSKTVVSETPYNTVLLNRDNDLHTMLFLDIDHEKGFMTIS
EAAQLLMQVDERGLLDRTLGIGIARAGSPDVVVKCNYLRDLARADFGAPMHLLIAPADLH
QMEAEALVRFAGAPEEITRAIGLQTYAEVTLKRNENE
>A0A521TC83|diphthine synthase|EC 2.1.1.98|Nitrosarchaeum sp|TrEMBL
MLWFVGLGISGSKSIPIEALEVLSKADIVYLEQFTSPIGKSDMLKIKNMTKGEFKQGKRW
LVEDGNEILKHAKTKKVVLLSYGDPYIATTHIELRTRAIQEKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKNFFMDPKDALIG
LIETEKGQKRNVIDLSTHAIVASRIGFKDQSIISGKISSLKKIDFGKPPHTIIITGRLHF
TESDALKILGKCLDKPQDNSEKTKKISIQMMKKYVPMVRDALEEITPYYKDQKEFKMILE
NAELYIQDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLEPKM
>A0A833DUD0|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MKELRNISPRRVCLADSMLKLIGLGLSADLITLRSLLELMKCKRILIDSYTSMWFPSLDS
LIDILRKLSKHCVKVYRESLEGKAINEIIAMSREEDVCIAVAGDPLIATTHSSLIVEAFK
QGVEVEVIPSTSILSIAISLSCLQAYRFGKCVTLVKPRNGIVFEYPIYVIEENRNRNLHT
ILLLDLDVAQGYYMTPKEAANLLVKLQERLGKRVLDYDDYLIILGAIGSEYGSIQVLKLY
ELIEGEERYNTPPYTLIIPAKKLHPMEEECIEMLRLRKLYFRPRISMTDIYKVIRVLSSD
YE
>A0A843EXT6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGLECLRNVDKIYAEFFTSRLFGSSFEAIEELVGQEIEVLVRG
EVEEEHKFIDEAKDGDVALITGGDPLIATTHSEFLVQCSKKGIDFEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYDAIEENLKMDLHTLVLLDIQAHKDRYMTVNQGL
EYLMNIKNDLDREGLITEDTLAMGIARVGSKDVVVRAGRISELIDFDFGGPLHCIVIPSK
LHIVEAEYLVEIAGADSSILDDV
>A0A843EX89|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFDKIEELIGKEIEVLVRG
EVEEEHKFIEEAKNCDVALITGGDPLIATTHSDFLVQCAKKGIKYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYVAIEENLKSNLHTLVLLDIQAHKDRYMTVNEGL
>A0A4S3TIN4|diphthine synthase|EC 2.1.1.98|Salinadaptatus halalkaliphilus|TrEMBL
MLTFIGLGLYDERSITVEGQRALRDANRAYAEFYTSELIGTSVADLESHHDVDIEVRDRA
GVEQRPEDILDAAEDEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVVHGITAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKIGHDRTDAD
EYMTADIGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMTDLADRDFGDPLHLLVVPGDC
HLLEADALVELAGADRDTLDIV
>L0ICT4|diphthine synthase|EC 2.1.1.98|Halovivax ruber (strain DSM 18193 / JCM 13892 / XH-70)|TrEMBL
MLTFVGLGLYDERSITVEGREAIHDADRVFAEWYTSELIGTTVEALADHHGVEIEVRDRA
GVEQDPDPILDAAASGDAVFLTAGDTMISTTHVDLRLRAEERGIETRIVHGVTAQTAASG
LTGLQNYRFGPSTTLPFPWAHGADGLPASVTNTIDENRDRGLHTLIFLDIKAAEDEYMRA
DTAATLLAEAYPDLVGIVVARAGSPDPLVDGGPLSELAERDFGDPLHLLVVPGECHLLEA
DALETLAGVDRNALDVA
>A0A2I0NXW3|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon HGW-Methanomicrobiales-5|TrEMBL
DMAEKKGVRIPLYVGIARAGADDPVIVAGPAEKMLAGNFGAPLHILIVPAELHEMEREYL
EIFAGL
>A0A849PX53|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLYFVGLGISGAKSIPLEAQDILSKADIVYLEQFTSPIGKSDLAKIKKMTHGEFKPAKRW
LVEDGNEILKNAKRKKVVLLSYGDPYIATTHIELRTRAIQEKIKTQSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYFVIYKNIIEGNHTILLLEYNQDKDFFLDPKDALTG
LIETEKGQKRNVINSSTYAIVASRIGFKDQSVTSGKISSLQKMDFGKPPHTVIVTGRLHF
TESDALKILGDCLDEPFDNSEKTKKISVQMMKKYVPMVREALEEIVPHYKGQKEFKVILE
NAELYIQDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A843HK01|diphthine synthase|EC 2.1.1.98|Methanosphaera sp|TrEMBL
MLYFIGLGLFSEDDISVKACKALNNVDVIYAEFYTAKLMGGDIDNLISRVDVPFIKLKRE
DVEDRNVVLQEAMDKDVAFVAAGDPLMATTHTELYVEAKNKGIDTRIIHGSSIFSAAPGL
SGLQAYKFGKTTTVPFPDDNFFPHSPYDAIKANMDMGLHTLVLLDIQAHRDRFMTVNEAI
RYLSKVESDRGEGVFTDDTIVIGIAQAGSDNPIVRGGRVCDVVDFDFGSPLHCMIVPGNL
HFVEAEALIALADIPEKLLERFL
>A0A150J3N0|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MLYLIGLGLSEKDLSLKAFELLSKINNIFVDTYTNYFDFDLLWLEKELNKKVIQLSREDI
EKRPIFLDIAIDQDVAILVSGDPLVATTHTDILLRAKKKGIKTKIFHASSIYSAIAETGL
HIYRFGKTASIPFPEENFFPKSFYDVILENKGRNLHTMLLLDVKKEKNLFMNPKDAMEIL
RSIDKDCNIQDIIIISRISHDSQRIIYGDIEELLKFNAEFYGLPPHTLVVPATLHFAEEE
YLISLAEIYKNTKN
>A0A7J9QJL3|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MLSFVGLGISGFESIPIEGLETISNADVVYLEQFTSPISETDLEKIKNSTKGEFKLAKRW
LVEDGNEILEISKEKNVVLLAYGDPYIATTHIELRARAIENKIQTNSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNLIEGNHTVLLLEYNQDKNFFLDPKDALIG
LLQTEQGQSRKVITESNYVIVASRIGFKDQAIVSGKISNLKEIDFGKPPHTIIIPGRLHF
TESDALKLFGKCIDEPFDNSEKTEKISNQMMKKYVPMVREALEEVEPYYKDQKEFEVILD
NAERYIKDAEIFLAEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A5J4DU95|diphthine synthase|EC 2.1.1.98|archaeon MnTg01|TrEMBL
MLCIAGLGISGIESISIETQKLLKNADIVYLEQFTSPVTKLESNKIRKLVKGEFKIAKRW
MVEDGKEILKNSKKKNVVLLTYGDPYIATTHIELRTRAIQEKIKTKTIHAASSITALVGE
CGLQYYKIGRIVTVMKDPKTLTTPYYVMYSNALAGNHTVLLLEYNQDEGFFLEPVNALLD
LLSTEKEQKRKIISSSTFVIIASRIGFKNQAITAGKISNLIKKNFGKPPHTIIIPGQLHF
TESDALKVFVNCVDEPFDNSKNIKKISEQMLEKYVPMVRKAVEEIAPHYKNSKEFQEVLE
NAELYIQDAEKFLEQGKDEVAVLSIGYADGLVDALRIAKGLNPKM
>A0A2Z2HIQ6|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosomarinus catalina|TrEMBL
MLSFVGLGISGFESIPIEGLETISTADIVYLEQFTSPISESDLKKIQDSIKGEFKLAKRW
LVEDGNEILEMSKEKNVVLLAYGDPYIATTHIELRARAIENKIKTHSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNLIEGNHTVLLLEYNQDKKFFLDPKDALKG
LLETEQGQTRNVITESNYVIIASRIGFKDQAIVCGKISSLKETDFGKPPHTIIIPGRLHF
TESDALKLFGKCIDEPFDNSEKTEKISNQMMKKYVPMVREALEEIEPLYKNQKEFEIILD
NAERYIKDAEIFLGEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A256I2J0|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Ea1|TrEMBL
MLTFIGLGLYDERSVTVEGRGALRAADRVFAEFYTSRLVGADVGELEAYHDVEIEVRPRE
GVERDPEAILSAAAEGDVAFCTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRESGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWRDELAVVVARAGSPEPVVAADRLSALSEREFGDPLHLLVI
PGDLHHVEADALAGLAGASPELVEE
>A0A0U3E974|diphthine synthase|EC 2.1.1.98|Methanobrevibacter millerae|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKSVDKIYAEFFTSRLFGSSFDKIEELIGKEIEVLVRG
EVEEEHKFIEEAKDSDVALITGGDPLIATTHSDFLVQCAKKGIKYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYVAIEENLKSNLHTLVLLDIQAHKDRYMTVNEGL
DYLMNIKDSLDYDGLITEDTLAMGIARVGSSDVVVKAGKISELIDYDFGGPLHCVVIPAE
LHIVEAEYLVEIAGADSSILDDV
>A0A101DKT5|diphthine synthase|EC 2.1.1.98|Thermococcales archaeon 44_46|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTDIRKIEEQIGKPIRLLNR
EDVELNFERIVLSEAKTKNVAFLTAGDPMVATTHADLRIRAKQMGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKENKERGLHTLLFLDIKADKGRYMTANE
AMEILLQVEEKKKEGVFTEDTFVVVLARAGSLNPTLKAGYVRDMMKEDFGKQPHVLIVPG
KLHIVEAEYLVAFANAPKQILNEV
>A0A849Q2F0|diphthine synthase|EC 2.1.1.98|Methanococcoides sp|TrEMBL
MLDFVGLGLFDEKDISLKGLEKIHNADKVYVEFYTSILMGTDLEKMEQLYEKKITVLSRE
DVEQHAEDWLVGAKDRNVVFLTGGDTMVSTTHVDLRLRAADMGIDTTLVHGASIASAICG
LSGLQNYRFGKSVTIPHPYVSSRGVRVVSQTPYDTIKKNIEAGLHTAVFLDIDKDKGYMT
VNQAMEILLEVEGKLGEGVMNDRLAVGVARAGSPSPVVKADYVEALRNYDFGGPLHIVVI
PAELHFVEAEALVKLAGAPEEILENVD
>A0A0W8FAA3|diphthine synthase|EC 2.1.1.98|hydrocarbon metagenome|TrEMBL
MLHFVGLGLYDERDISLKGLEAVRAADCIYAEFYTSRLMGTTLEKMEALYGRKIHPLSRQ
EVEVDPSWLEEGRNKDIVFLSGGDAMVSTTHLDLRLRAIKMGIEASVIHSSSIVTAVSGL
CGLQNYRFGRSTTIPFPYVSRGRRIIPQTPYQVLRENQERNLHTMLFLDIQMEPVERYMT
ANEGTALLMEMEANAGESGLMEAIAVGIARAGAPDASVKADLLPRLQGYSLGGPLHILII
PARLHFMEAEALRILADAPADAVQC
>A0A8J7Y9H2|diphthine synthase|EC 2.1.1.98|Methanothermococcus sp. SCGC AD-155-M21|TrEMBL
MLILAGLGLYDERDITLKTIEYAKKADNIYAEFYTATLTGTTLEKIEKTLGKKIIVLSRE
KVEYETNKLLDESKERNIMFLTVGDPMVATTHVDIAVEARKKGIELIIINAPSIYSAVGI
TGLQIYKFGKTTSIVFPEPKYFPETPYHVIKNNLNMGLHTLCLLDIQADKNKFMLANEGL
EILLRIESNRKENILKKDTKAIVLARAGSLNPKIAYGKIVDLIDYDFGSPLHCIIIPGKL
HFMEEEALKYLCENI
>A0A328Q5T7|diphthine synthase|EC 2.1.1.98|Methanosphaera stadtmanae|TrEMBL
MLYFIGLGLFSEDDISYKGFKALKSVDCIYAEFYTAKLMGGNIDNLIEKLDVPFITLKRE
DVEDANVIIKEAMTKDIAFVTAGDSLMATTHTELYVEAINKGIKTQIIHGSSIFSAAPGI
SGLQAYKFGKTTTVPFPDENFFPHSPYDAIKLNSQMGLHTLVLLDIQAHKDRYMTVNQAL
DYLSKVESERKEHVFDDDRIVIGIAQAGSKHPIVKGGRVSDVKNFDFGKPLHCIIVPANL
HFIEAEALITLADVDKELLKDFL
>N6VTC6|diphthine synthase|EC 2.1.1.98|Methanocaldococcus villosus KIN24-T80|TrEMBL
MLILAGLGLYDEQDMTLKTLNFAKKADKIYAEFYTSILTGTSIEKIEEVIGKKIEILYRE
DIENSYKVVEEAKEKDVMLLTAGDPMVATTHIDLVIEAKKRGIKVIIINAPSIYSAVSIT
GLQIYKFGKTASIVFPEKNYFPETPYNVIKENLERGLHTLCLLDIRVEKNEKKFMTANEA
LKVLLEIEKKRKEGVINLDTKAIVLARVGSLEPLIVYGKIRDLIDYNFGKPLHSLIIPGK
LHFMEEEALKYLAINL
>A0A345E5M4|diphthine synthase|EC 2.1.1.98|Haloplanus rubicundus|TrEMBL
MLTFVGLGLYDERSITVEGRDALRAADRVFAEFYTSRLVGTSVDALEAHHDVDIEVRDRA
GVEQRPEPILDAAEDESVVFLTAGDTMISTTHVDLRLRAMERGIDTRVIHGVSAAQAASG
LTGLQNYRFGKAVTLPFPRAHGGDGVPASVVESVAANRERGLHTLVYLDIKIDDGRGTEA
GETYMTADVAAGLLAEEWPDRLGVAVARAGSPDPVVVADRLSALADREFGDPLHLLVLPG
DLHHVEADALRTLGGAPADLLPE
>A0A0E3Q5Q1|diphthine synthase|EC 2.1.1.98|Methanosarcina vacuolata Z-761|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSFLMGTNLEKMEKLYGKKVFLLSRE
DVEQHPDWLSKAKDSNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
AGLQNYRFGKSASIPHPYESRRGTRIISETPYDIIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIMRGAIAVGIARAGSEKPVVKADYAEKLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAGGPAGFMKEVE
>A0A832SXX3|diphthine synthase|EC 2.1.1.98|Pyrococcus horikoshii|TrEMBL
MVLYFIGLGLYDERDITVKGLEIAKKCDYVFAEFYTSLMAGTTLGRIQKLIGKEIRVLSR
EDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIRAKRAGVESYVIHAPSIYSAV
GITGLHIYKFGKSATVAYPEGNWFPTSYYDVIKENAERGLHTLLFLDIKAEKRMYMTANE
AMELLLKVEDMKKGGVFTDDTLVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPG
KLHIVEAEYLVEIAGAPREILRVNV
>A0A7C1DVD1|diphthine synthase|EC 2.1.1.98|Methanoculleus sp|TrEMBL
MLTFVGLGLYDEQDISLKGLESIRRADRVYLESYTSVLMGADVPALEQLYKKPLIILGRE
DVEQNPEPILEQAKTGEVAFLTGGDPMVSTTHADLRIRAAREHVATRIIHGASISSAVCG
LTGLQNYRFGKSCSLPFPARGWFPTTPLETIRQNQNQNLHTLAYLDIQEHRYMRVRDGIA
SIEGMAEALGLPAPSLYVGVARAGSPEPFVAAGDAERLNQIDFGPPLHILVIPAELHVIE
KEYLEMFAGL
>A0A101DY45|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus|TrEMBL
MLTFVGLGLWDVKDISVKGLEAVREADEVYVEFYTSKLLSSIEEMEEFFGKRVVELERID
LEENSFRLIERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVCGL
TGLHNYRFGKSATVSWHRSQTPVNVIKANRSIDAHTLLFLDLHPEPMTIGHAVENLIAED
AQMKDLYAVGIARAGSGEEVVKCDRLENLKKIDFGKPLHVMVVLAKTLHFMEFECLREFA
DAPAELERLVA
>A0A101DEZ9|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus|TrEMBL
MLTFVGLGLWDVKDISVKGLEAVREADEVYVEFYTSKLLSSIEEMEEFFGKRVVELERSD
LEENSFRLIERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVCGL
TGLHNYRFGKSATVSWHRSQTPVNVIKANRSIDAHTLLFLDLHPEPMTIGHAVENLIAED
AQMKDLYAVGIARAGSGEEVVKCDRLENLKKIDFGKPLHVMVVLAKTLHFMEFECLREFA
DAPAELERLVA
>A0A166A9U3|diphthine synthase|EC 2.1.1.98|Methanobrevibacter filiformis|TrEMBL
MLYLVGLGLFDEKDISIKGLETLKKADLIYAEFFTSNLFGSSLKTIERLIGKEIIVLNRE
EVEEENIFFKEAKHKNVALITGGDPLIATTHSDFLVEAKNKGINTSIIHGSSILSSAPGI
SGLQAYKFGKVTTIPFPDENFFPHSPYLAIEENLKNNAHTLVLLDIQAHKNRYMSVNQGL
EYLIKVKEELIGTGQDVSIDENTLAIGIARVGSSDVIVKADKIDNLLNFDFGSPLHCIVI
PSKLHIVEAEYLIAIAGADNGILQEYY
>A0A847UHY8|diphthine synthase|EC 2.1.1.98|Haloarcula argentinensis|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLESSLGTSIEVRDRA
GIEQDPEPILEAAERENVVFCTAGDTMVSTTHTDLRLRAEDRGIETRMVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIKSNRDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVVADTLDELATQTFGDPLHLLVIPG
SLHPLEADVLESLAGAAVE
>A0A7J3JDZ3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSELVFVGLGLNDDKGITLKGLEETQSATAVFMETYTSRMPDFNMERFEAQIGKKVQLIT
RSDLEEDSGKVILQAAKTGKAVFLVPGDPFIATTHVTLRIDAEKMGIKTRVVHGISIMSA
IVSLSGLHNYKFGKTVTVPFADNFSETPYNVIVQNKKLGLHTLCLLDLRAAEGKYLSIKD
ALKQLQMVEEKKKQEAITPLTVAVGIARAGSNDPLVKAGFVKDLVDWDFGEPPFSLIIPG
DLHFMEIDALLAFAGAPDEFRRLAK
>A0A497JM92|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGSLTFIGLGLHNEKGLSLVGLEKARKAEKVFIETYTNPMPHLSMENLQKLLGKPIVRLS
RGDLEENAKNGILRDAKKMDVVLLVPGDPMVATTHVWLRVEALKMGIKTEVVNGVSVYSA
APSVAGLQIYKFGRSVTIPIPTENYKPQTPYDVIKENSKRGLHTLVLLDFSSEKNRWISI
GEGLSYLLEIEEERKEKVVFRGRLAVGLAGLGSDKPVVKGDTVEKLLSYDFKLFPQTLIF
PGRLHFMEVEALKVFAETPEEVLKLYV
>A0A537HJ09|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MPKVTFIGLGLDSERGITLEGLDAARNASSVFAEFYTNLMPNLDVANLERLVGKKVAVLN
RQDIEDSHGKDVLLAAKEGDVTVLVPGDPMVATTHVALRLSLAKRGIESRIIHSASIISA
VCGATGLQNYKFGRSVTLPAESTVPKSVIQTLVENKQRASHTLLFLDVRIEEKAQLTIPE
AVEKLRKILPESSDWLAVGLARVGARDQLVKAARLDRLSKQTFGGPPQVMVFPSKLHFME
AEALKVFCGAEDGDLEGTA
>A0A497L4Z7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEVVFVGLGLHDDLGISLRGLEEVKSADEVFIELYTSFMPEFSIKRFEGFSGKRLRVVS
RKELEEEDGEAVLRAAEKGKVVLLVPGDPLIATTHVALRVNAEKRGIKTRVVHGASVLSA
VIGLSGLHNYKFGKSVTIPFPSGAVSETPYDVIAQNRRLGLHTLCLLDVRAEEKRYMKIR
EGLDLLLKVEEKRKEGIVTFDTLAVGVARAGSSTPTVKAGFVKELLSYDFGMPPHSIVFL
GRLHFMEVEALVVLADAPEKLRRMRR
>A0A497LFP2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVGLRDLGELVFIGLGLRDEKDISIRGVEEAEKADFIFAELYTSLLVGFSPSKLEKIIGK
EITFLSRHDLEDDNGEVILRKAEKGRVAFLVPGDPLIATTHVALRIGAEKRGIKTKVIHS
ASIISAAMGLSGLQNYKFGRSVTIPFPRGEIISRTPYDVIAENKARNLHTLCFLDIDAER
KRYMKINDALRILLSLENKIRKEIISDRSLAVGISRAGGEDVIVKAGAIKDLLIFNFGDP
PHTLIIPSEKLHFVEAEALRVLADAPEWVGKMIK
>A0A7J3R0E4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKTLVFVGLGLHDERGISLRGVEEARSADTVFVELYTSVMPGFSLERLEKLLAKPVRQLT
RREVEEEGARVILEAAEKGKAVFLVPGDPFVATTHLSLRVEAEKRGVATRVVHSASVASS
VISLSGLHNYKFGKTVTVPFAENFSETPYTVIAQNKHSGLHTLCLLDINVEEKRFLSVNE
ALSSLLKVEEKRREGAVTLETLAVAVARAGSDMPLLKAGYVAELQTQDYGDPPYSLVFPG
KLHFTEAEALVTLAHAPLQVRSEAH
>A0A7K4IQ29|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSGEIVFVGLGLHDETGLSLRGLEEAKTADTIFVELYTSFMPDFSIRRLEEICSKKLCMV
SRRELEDENGKIILRAAEKGKAVLFVPGDPLIATTHIALRIHAEKTGIKTRIVHGASILS
AVMGLSGLHSYKFGKSVTIPFPDQTFSETPYEVIAQNQMLKLHTLCLLDIIAEEKRYLGI
RKSLEFLLAIEKKKKRRIITKDTLVVGIARAGSNEPKVKADSVNRLLEYDFGEPPYTLIF
PSKLHFMEAEALIVFADAPERLRDEAE
>A0A126QW08|diphthine synthase|EC 2.1.1.98|methanogenic archaeon mixed culture ISO4-G1|TrEMBL
MTSELIFVGLGLSGTDGMTVKALHALKECDKIYAEFYTSLLIGTKVEDLEAAIGKKIKVL
YRAQVEECDDIIRDALEMRVGFVTAGDTMSATTHVDLRIQAAEAGIPVRLFNGITIFSAC
PTVFGLQNYKFGRTVTLPFIEQGYHPKSPYDHIMANKKMGLHTMILLDIHADEMRYMTAH
EAIEWLMLGEEKWGEGLIDDRTILCVASRVGSPDEKIFAGYPQDLLKMDLGEPLFTLVLP
GNLHFMEQYALVKFAGAPEDIIEDE
>A0A1F9Z944|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon RBG_16_68_13|TrEMBL
MGELLFIGLGLHDERGISLRGLEEARSCDTVFAEFYTSALPGLAPDGFRRLLDKEIRVLT
REEVESGEKILDAAARQRVALLVVGDPMAATTHVDLRLRAAAAGISTRVIPGTSVLTAAA
GAVGLQSHKFGRTTTIPFLTASFHPTSPAEVVVANLRAGLHTLVLLDVREEGGFLDPKAA
LRDLIATPLRLEAGELGPGTLVVVLSHVGSPGARFVTGRIRDLLDRDLGPPPHCLIVPGP
LHFLEKEALAAFAGLQEG
>A0A534KU96|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELIFIGLGLDDEKGVTLRGLDEAQSSDIVYAERYTSGFSDTSLDAIEKLVGKTVHRLT
RKEVEDGEVILAAAVRGKVAFLIAGDPMAATTHVDLRLRAASRKIPTRIVHGVSILTAAA
GALGLQIYKFGRTTTVPFSSAGFAPTSPLEAILTNRRAGLHSLVLLDLREDGSCLAPRDG
IASLLKMASSLGSSEFGPDVLAAVLSRVGSPHVRVFAAPIARLAARDLGPPPHCIVIPGS
LHFLEKEALVAFAGAPQDL
>A0A365T8N1|diphthine synthase|EC 2.1.1.98|halophilic archaeon|TrEMBL
MLTFIGLGLYDERSITVEGRDALRAADRVFAEFYTSHLVGATVDDLERYHDADIEVRDRA
GVEQDPEEILAAAEDGDAAFVTAGDSMMSTTHVDLRLRAEERGIDTRVVHAPTAQSAAAG
LTGLQNYRFGKATTLPFDYAHGADGLPASVTDALDENRERSLHTLVYLDIKEDRGDYMTA
STAADMLASGYEDVLAVAVARAGSPNPVVEADRLSELAERDFGDPLHLLVVPGDLHHIER
DALATLADAPADLLDEKLA
>A0A1G9UKV1|diphthine synthase|EC 2.1.1.98|Haloarchaeobius iranensis|TrEMBL
MLTFIGLGLYDERSITVEGQAALRAADAAYAELYTSKLVGASIEDVAEYHDADIEVRDRA
GVEQQPGEILDAAEDQDVAFLTAGDTMISTTHVDLRLRAHERGIDTRVVHGTTAQTATSS
LTGLQNYRFGKATTLPFEYAHGGNGVPQSVLDTIADNRERGLHTVVYLDIKVGRGPDGDD
PAHEEYMTADHAAGQLAEHLPDTLGVVVARAGSPDPLVTADRLSALADREFGDPLHLLLV
PGDLHPIEADALGELADAPSELVQY
>A0A7K4C8M7|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLFEKTDISVKGLRCIEQADAVYLECYTSRLMGSSIEELSAFYQKPVLPLYRE
DVEQHPDAMLDRAANENVVFLCAGDPMVSTTHADLRIRAAERGIPTAIIHAASIQTAVCG
LSGLQNYRFGKSCSLPFPQKNWFPTTPMDVISQNLSLRLHTLVYLDIQNERYMTIPEAVE
LLEKMAAMKGVTIPVYVGIARAGSPAPVVLAGPAGRIRAADFGEPLHIMVIPAELHDMEQ
EYLARFAGL
>A0A7K4B1V2|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLIFAGLGLYDLDDISIKGFNAIKEADLVFLEAYTSILSGTTPEEMRKRYGKEIIILKRQ
DVEQEPEPILDAAEKGNVVFLTGGDPMVSTTHADLRIRAKERGIQTRIIHGSSIVSAVCG
LTGLQNYRFGKSCSIPYPSHNWFPKTPLDTILSNLKQNLHTLVYLDIQENRFMSVREGIE
ILERLMDGSSESIPLYVGVARAGSDMPVVVAGTGERLKSIDFGPPLHIIVVPARLHEIEE
EYLKDFAGYVNQ
>L9Y0T7|diphthine synthase|EC 2.1.1.98|Natrinema versiforme JCM 10478|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSKLIGTTVDDLEAAHDIEIEVRDRA
GVEQEPDDMLAAAETEDIAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNQDDGLHTVVYLDIKAEREEYMTA
DVGAELIAEEYPDLAGVVVARAGSPDPLVEAGTMAELADREFGDPLHLLVVPGECHLLEA
DALVELADADRESLRIA
>M0HFF1|diphthine synthase|EC 2.1.1.98|Haloferax gibbonsii (strain ATCC 33959 / DSM 4427 / JCM 8863 / NBRC 102184 / NCIMB 2188 / Ma 2.38)|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIGIEVRDRA
GVEQDPEPILDAAEDDHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A2V3J945|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MLTFVGLGLYDEKDITLKGLEAVRKADKVYAEFYTSPLGGRTVEKMQRVYGRRISVLERS
DLEENAEAAESGGILELAKSKNVVLLCGGDSMVATTHVDLRLRAIDREIKTRLIHAPSIL
SAVAGLCGLQNYKFGKSATVSPPYPHGCGGVISEVPYDTLKANKERGLHTLLFLDISMSV
NEALGLLETVEERRRGTVLKNKKSIIVGIARAGSEEPVVKADYLEGLKSYDFGELPHVLV
VPGELHFLEKEALVKIANFPAP
>W0I7J9|diphthine synthase|EC 2.1.1.98|Thermococcus paralvinellae|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLIFAEFYTSLLAGTTIERIEELIGKPIRVLNR
EEVELHFEKIVLSEAKNKDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
SITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTLLFLDIKADQGRYMTANE
AMEILLQVEEMKKQNVFTPETFVVVLARAGSLTPTLKAGYVKDMIKEDFGKQPHIMVVPG
RLHIVEKEYLVTFADAPEEILKRRDL
>A0A832UDX1|diphthine synthase|EC 2.1.1.98|Methanocalculus sp|TrEMBL
MLTFIGLGLFDEHDISLKGLAVIREADAVFLETYTSRLMGADMPALEALYQQPIRLLSRE
DVEQHPEPILDAAESGSAVFLTAGDTMVSTTHADLRIRAAERGIRTTIIHAASIASAVCG
LSGLQNYRFGKSCSLPYPEARWMPTTPVEVIAANRSQNLHTIVYLDIQKERYMRISEAIA
IIEEIGARLTITIPLYVGIARAGSDDPVVIAGTGDDLKRMDFGPPLHILIVPADLHMIER
EYLELFAGLPPESDSIQ
>A0A7C4D7P4|diphthine synthase|EC 2.1.1.98|Staphylothermus marinus|TrEMBL
MLIFIGLGLSIKHLTLEAIYWLNNVDKVIIDTYTGFTDGFDIDFIKNITCNKSVEIVLAE
RKDLESRAINDIIEEARFRNIAILVPGDPFIATTHDAIRVEALKSNVKVIVVNGLSIHTL
AISRTGLQSYRFGKTVTLVYPDVSKPYSVVDVIYDNITRNLHTLVLLDYRSDENKYMSIP
EAVNLLLDLDYKNLLDRIIGVGLARIGTIDEYIVADILPDLRDYQYPKPPHSLIIVAKPH
PVELDCLKNICKLPDRLYRKYLSSKEYP
>A0A0D6JSI3|diphthine synthase|EC 2.1.1.98|Haloferax massiliensis|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETHLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPEPVVAADRLSALAEREFGDPLHML
VIPGEVHHVEADALSALGGAPEELFDES
>A0A842YNS0|diphthine synthase|EC 2.1.1.98|Methanothermobacter thermautotrophicus|TrEMBL
MLYIIGLGLYDEDDISIKGLKAIEDCDEVYAEFYTAMLQGSSLSAIEKRIGRRVKVLGRG
EIEEERIPIERASEIDVALLVAGDPLVATTHTELLIDAHRRGVETRVIHSSSIVSAAPGL
AGLQAYKFGRIITIPFTTDNYFPTSPYTNIGENLEAGSHSLVLLDIEAHRDRYMTANEGL
RYLLRASEKLDDDTITGETLAVVIARAGSEEPVVRADRIDALVDEDFGDPLHCLVIPAGL
HFIEAEYLVEIAGAPRAVVERMIL
>A0A849PWA7|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLYLIGLGIGDEKDISLSGIEACRKAEKVFLELYTCPLKIDISYLEKIIEKKITVLDRKG
VEESGKIISSAIEKDTVLLVGGDPLSATTHAEIILEARKKGIKVEIVHSSSVFTAVAETG
LSLYKFGKAVSLPRPQDNYFPTSPYENISDNLSNGMHSLVLLDIGMDAGEGMSILLDLEK
KVKDGIFSSETKIIACAHLGKGSFIRYGMIKDFQKADFGEHPHCLIIPAKLNFSEEEFLE
SFR
>A0A7J3BP83|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLLLVGTGVNNDITIGALEELKRCEKVYAEVYTNPMIREFLPQLEKMIGKRITELQRDKV
ESSFLITEAINKRIALVVGGDPLTATTHIVFVSECRKRNIPVKVIHNSSIYSVAPARAGL
QIYRFGKTATLVNPRENYNPTSSLDIIRENLSRNLHTLVLLDTEPQPMKIEIALEKLSEF
ERAVVLSRVASEDETITYGNIKELLKHAKDLGEPPFTIIIPAKLHIVEEEYLEWYKLKKE
EKNE
>A0A662VQW3|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon|TrEMBL
MLTFVGLGLWDEKDVSIKGYEAVKRADEVYVEFYTSKLLGTDIDKISKFFGRKVWVLERK
DLEEESFRLIDKALNKNIVILIPGDPMIATTHSALRLEAEKKGVKTAIIHGASIVSAVCG
LTGLHNYRFGRSATISYPYKGKVSKAPMDIIKKNRSIDAHTLLYLDLHPKPMSINEALEI
LLKIEDVEDKYAVGIARAGSNNPFVKCDRIGELLKVDFGEPLHVLVVLAKSLHFMEFECL
KKFADAPDDLKKFIV
>E1RIJ5|diphthine synthase|EC 2.1.1.98|Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)|TrEMBL
MLYFVGLGLFDEKDISIKGLERIRDSDEIFLESYTSRLTGTNIQKMELLYGKKLTILGRQ
DVENEPEKILEAAKKGDAVFLTGGDPMVSTTHSDLRIRAMREGIETAIIHASSIQSAVCG
LSGLQNYRFGKSCSVPYPEKGWFPTTPLNTILKNLDDNLHTIVFLDIKPDRFMTVNEGIE
IIEQMAGMENKTPPKLYIGIARAGSDAPAVIAGDAEKLKSADFGDPLHILIVPGELHMME
QEYLETFAGL
>A0A7J4B2J0|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MFYLVGTGLWRGDDISVRGAEVCKKANSVYLDGYTRAFEESELLRLEEIIGKKIVALERN
ELEEGLSFLKEAKEKEVVLLVPGDPLIATTHITILEEAKKRGIGFEVIHGSSIYDALIGE
AGLHIYKVGGSCTIPMRKKGIKPYSVYEKLAENKSKGVHTLVFLDTEPGKEMDIREAFDI
LGEIESEKKMGICTDDNKIIVGCRVGSGEQRIIYGEIGRIKKMELRGPCALIFPGKLHFS
EEEYLKGLEI
>A0A662QZ98|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLIGLGLWDEKDISIRGLETAKKCDFVFIEKYTSFWTGNLKNIGITAEEIKRTDLEDN
VDKILEKSKDKDIAILIPGDPLVATTHISILLEAKKKNIETKIIHSSSIFSAVLETGLQI
YKFGKIATIPFYQTEVPYKILEENLKNGAHTLFLLDITKEKLMSCAEGLKILLDLENKFK
KKLISKETEVVVFCRVGSSEQILKYDKIKNLIDLNCSPCVIIIPGKLHFLEKEFLTSLKN
>A0A7C5JYD1|diphthine synthase|EC 2.1.1.98|Thermococcus litoralis|TrEMBL
SYVIHAPSIYSAVAITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKKNKERGLHTLLFLD
IKAEQGKYMTANEAMEILLQIEEKKKEEVFTEDTLVVVLARAGSLNPTIKAGYVKDMIKE
DFGKQPHILIVPGRLHIVEAEYLVAFADAPEQILKEV
>A0A5E4LGU6|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MELLGDLLLCIVGIGLKPKHVSIEGLETIKACKRAYIEEYTSQYAESSLRELEALAGKQF
VPLSRSQVEEEFSGILEEAKHLDVCLAVFGNPMDATTHIQILLDAQKAGTETKIVPATGI
FDFVSVCGLERYKFGRTTSIVFHEEGYEPESFYDAILENKKAGLHTLCLLDIRKDESRLM
SIKHAISLLESIEERREKAVLSESITLGIAGAGSENQQLKAGTMEQLKLSSFTSFPQCII
VCGKLNEKEIEGMRAFAGLG
>A0A6G8TA84|diphthine synthase|EC 2.1.1.98|Haloarcula sp. JP-L23|TrEMBL
MLTFVGLGLYDERSVTIAGRDAIRDADRVFAEFYTSRLIGTDLESLEAYHDTTIEVRDRA
GVEQDPAPVLDAAETDDVVFLTAGDTMVSTTHTDLRLRAEERGIETRVVHGTTAQTAAAS
LTGLQNYRFGKATTLPFERAHGGDGVPDSVVQTIEDNRSRNLHTLVYLDIKVDDPHWDDS
DDTYMTADHAAGLLAESFPETLGVVVARAGSPDPAIVADTLDELATRSFGDPLHLLVIPA
DLHLIEEDALTAIADAP
>A0A846PYT6|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLWFVGLGISGAKSIPLEAQEVLGKADIVYLEQFTSPIGKSDLTKIKKMTKGQFKTAKRW
QVEDGNEILKNAKRKKIVLLSYGDPYIATTHIELRARAIEEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSDMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKEAIIG
LLETEKGQKRNVINPNTHAIVASRIGFKDQSIVSGNFSSLKKQDFGKPPHTVIITGRLHF
TESDALKIFGKCIDEPSDNSEKTKKISVQMMKKYVPMVREALEEVEPLYKDQKEFQTILE
NAELYIQDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGMEPKM
>A0A8J8AA69|diphthine synthase|EC 2.1.1.98|Thermococcus sp. MV11|TrEMBL
MAIYFIGLGLYDERDITLKGLEAARKCDLVFAEFYTSLLAGTTLERIEDLIGKPIRRLSR
EEVELHFERIVLSEARERDVAFLTAGDPMVATTHADLRIRTKQLGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLSPTLRAGYVKDMLMEDFGRQPHVMVVPG
RLHIVEAEYLVEFAGAPKEILETV
>A0A832URC8|diphthine synthase|EC 2.1.1.98|Candidatus Undinarchaeales archaeon SRR5007147.bin71|TrEMBL
MIKIIGIGLWDERSMTIQAQEEAADCDILYAEFYTSKMFGSSLKKLEKKIGREIQELSRE
EVESGTEILKKAKTQKVGLLVGGDAMTATTHSQLILDSAKVGVESKIIHGVSIVSSAAGL
SGLQVYKFGKTVSIPFEDLESPYNIIEENQSIGAHTLCLLDIRDGKFMTVNEAIRKLLKI
EKTRGENVFMKDSLAVGIARAGSPKPVVKAGTAEELLKKNFGEPLQVLIIPGKLHFAEEE
ALELLKK
>B9AED4|diphthine synthase|EC 2.1.1.98|Methanobrevibacter smithii DSM 2375|TrEMBL
MFLKSYIMFYLVGLGLFDAGDISLKGLECLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A6B2CEP5|diphthine synthase|EC 2.1.1.98|Thermogladius sp|TrEMBL
MLILIGLGMKFDDLTLQAVDYIRGADVVYIDTYTNIYEDYSKLIELVKSKKYKLAGRNDL
EGDSISRIVEEASRWNVAILVPGDPLIATTHEALRVEAVRKGVKVVVVNGLSIATLAFSR
TGLHFYKLGRTITLTYNRESAEYVVNAIYDNISRGLHTLVLLDIKVEESKAMSIPEAVEI
LLESDKKGVLGERVAVGIARLGFSNEFIVADLTENLGNYAYPPPPHSIIIPGDLHFMEIE
SLRYNCRLPIGVYEKLAGGRI
>A0A7J4K786|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLTLIGLGLRDGNDITLRGLDAVKRAAAVYIEGYTSLLQCSHQTLEAQLGRDVVKLTRDD
VETGIDAVLTRAKTEDIAILVVGDVFGATTHTDLYLRAAQAGVHIEVVHNASVMNAIGIV
GLELYRYGKTVSVPYWSPGFEPTSYLDGIRDNKALGLHTLCLLDIKADEGRFMSVSEGLA
LLLAAEERKRYGALAHDALVIGVARIGCADMIIQPGPLSDVANMDFGAPPHCIIIPGRLH
QVEEDMLAHWMKTK
>A0A7J4LIK8|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYMIGLGLNDEKDISLKGLEAVKECDYVFLEGYTSRLNVSLERLENFYGRAIVLADRE
MVENNSDQIINKAAASNVAFLVVGDIFSATTHIDLFLRAKEKGIQIEMIHNASILTAVGS
VGLELYKYGKTTSMPFFEPSFEPETPYDVIKMNLKNGLHTLVLLDIKPDRFMSVNHALAQ
LLEIENRRKEKVISEKTGVIGCARLGSRNQLIKYGSVHELLDFDFGGPLHCLIIPGKLHF
MEEEMLRFWEINQSD
>A0A075GFL7|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote KM3_133_A04|TrEMBL
MLTLVGLGLGGPESLTQDGIAVIREASALFAEGYTSPLLPETLAWVEQAAGRVRLLSREE
VEQPETLLAAARDGDAVLLIGGDPLSATTHVSLRLQCGEAGIECRVVHNASVLTTVAGEL
GLQHYRFGPVATLVTPQGDYRPLSPVKRVLQNIEAGFHSLVLLDIRADDPAIESRLMTAT
EGAALLLEGGVATGARACAAARVGRSDQQIWCGALGEMAQAKIGAVPHSIVIPGELHFVE
EEALAAMQE
>A0A843ICK9|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MTSELIFVGLGLSGTDGMTVKALNALKECDKIYAEFYTSTLIGTKVEDLEAVIGKKIKVL
YRAQVEECDDIIEDAKTMRVGFVTAGDTMSATTHVDLRIQAAEAGIPVRLFHGITIFSGC
PTSLGLQNYKFGRTVTLPFIEDNYHPRSPYDHIKQNKDLGLHTMILLDIRADELRYMTAH
QAIEWLLEGEKKWGEGLVTDDTLLCVASKVGSPEERIFAGYPKDLLEMDLGEPLQTLVLP
GNLHFMEAFALVRFAGAPESILDDE
>A0A8J8DRX6|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 18S1|TrEMBL
MAIYFIGLGLYDERDITLKGLEVARKCDLVFAEFYTSLLAGTTLDRVEELIGKPIRRLSR
EEVELHFERIVLSEAKEKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMLKEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A7J3Y0S9|diphthine synthase|EC 2.1.1.98|Thermogladius calderae|TrEMBL
MLILIGLGMKFDDLTLQAVDYIRGADVVYIDTYTNIYEDYSKLIELVKSKKYKLARRNDL
EGDSISRIVEEASRKDVAILVPGDPLIATTHEALRVEAVRKGVKVVVVNGLSIATLAFSR
TGLHFYKLGRTITLTYNRESAEYVVNAIYDNISRGLHTLVLLDIKVEESKAMSIPEAVEI
LLNSDKRGVLGERVAVGIARLGFTNEFIVADLTENLGNYGYPPPPHSIIIPGDLHFMEIE
SLRYNCRLPHRVYEKLAGRRI
>A0A832BQ63|diphthine synthase|EC 2.1.1.98|Archaeoglobus sp|TrEMBL
MLTLVGLGLHDYKDITLRGLEAVRDAEEVYLDTYTSKISCSLEDLQEFFGKEIREAKRSD
LEEGSRKIIEMAKEKKVAILVPGDPTIATTHVSLLLEAKRSGVKTMVINNASIINAVCSL
TGLQNYRFGRSATVSWHRSKAFIDTIKANLSIDAHTLLFLDLNPPMTIKEAVERILSLES
SFAEHFAVGIARAGSENAVVKCDELEKLRYFDFGDPLHTLVILARRIHVMEYECLRYFAS
APEGLKEWVL
>A0A0S1XCF1|diphthine synthase|EC 2.1.1.98|Thermococcus barophilus|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLIFAEFYTSLLAGAKIEKIEKLIGKPIRVLNR
EEVELHFERIVLSEAKNRDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
SITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKADQGRYMTANE
AMEILLQVEEMKRQNVFTPETFVVVLARAGSLNPTLKAGYVEDMIKEDFGKQPHIMVVPG
RLHIVEKEYLVAFADAPEEILRRRDL
>A0A1Q6DU36|diphthine synthase|EC 2.1.1.98|Candidatus Methanohalarchaeum thermophilum|TrEMBL
MSLYFIGLGLYDEKSISVRGLEEAKDCDKLFAEFYTSKLMGSSLNDIENLIDSEIICLSR
DKVERSDLIVSEAEEAKVGFLVGGDPMISTTHVDLRLDAIDRDVDVRIIHGTSIYTAAPG
LAGLQNYKFGRSATLTFPRNDKYPRSAFNAVKENRGRGLHTLLFLDLEEDGNFLSPSEGL
EYLMEVVREEKSDLINLETVCVVVGRAGSSDPELVVDEIGELIERDFNQPMYILIVPGDL
HFREEEALDKLKQV
>A0A0F8FPV3|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 2.H.T.1A.6|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRRESVMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVNLAAGPEEIMEEME
>D9PUZ9|diphthine synthase|EC 2.1.1.98|Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)|TrEMBL
MLYIIGLGLYDENDISVKGLKALKACSRVYAEFYTAILQGASLSAIEELTGKDIDILRRE
EIEEERIPLLEAEKSDVALLVPGDPLVATTHTELILDARRRGIETRVIHASSIISAAPGL
AGLQAYKFGRIITVPFTSENYFPTSPYVNIRDNLERDSHSLVLLDIEAHKRRYMTANEGL
EYLLRASEKLGDDTINEKTLAVVIARAGSERPLVRADAISSLIKEDFGDPLHCLVVPGAL
HFIEAEYLVEVAGAPRSIVEGMII
>A0A662LF44|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGRLIFIGTGLMGGDWITTRGIEAAREVDFLFAEFYTSYIGDEGVKRLENILGRRIVRLS
RDEVEMKERLFKYLEDGDVGLLVGGDPMAATTHVELRLEAERRGHRTDVVYGVSIFSAAP
SSVGLQHYKFGRVVSVPWVSEKFMPRSVLEGIEGNLRCGLHTLLLLDLKDGEGFMSVNEC
LRTLLKLEERHEMGVVNEETLVVGAARIGDPTECIKGGALSEMLEENFGPPLHVVVIPGR
LHFVEEEALRTIAGVRDDVLERWKNRIESFCPKGPTPS
>L9WDK7|diphthine synthase|EC 2.1.1.98|Natronorubrum sulfidifaciens JCM 14089|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSNLIGTTVDDLEAHHDVDIEVRDRA
GVEQHPEDILAAAEAENVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTRTIDDNREDGLHTVVYLDIKVDNDAATNR
LEGDETVEEYMTADVAADLLAEEYPDLVGVVVARAGSPDPLVEADTMTALAKREFGDPLH
LLVVPGDCHLLEADALVELAGVDRADLDVV
>A0A4U7EZG3|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SD626R|TrEMBL
MLTFIGLGLYDERSVTVEGREAIRAADR
>A0A117SWJ6|diphthine synthase|EC 2.1.1.98|Vulcanisaeta sp. CIS_19|TrEMBL
MGKKNPTLYLVGLGLSPGNLTIDALNIIRSVDKVFMETYTSKAPGELIKQIMGIRHDIVF
LSREDLEDRSGNAIISELSKGRNAALLVIGDPMMATAHAAILVIAKRLGFEVRIINSVSI
VCAILSQLGLSPYKLGPIATITYPRMGILSMRAYEILNDNLRRGLHTILLLDIKDGNEFM
SASEAIDLLRKMEENGKLGIINNDLLVIYAARIGWENQSIVVSTINNVPSLGETPHTIII
PGLLNPVEIDYLTYVLNADKDLVLKHQRWVNKLMNGN
>A0A346PHM6|diphthine synthase|EC 2.1.1.98|Natrarchaeobaculum sulfurireducens|TrEMBL
MLTFIGLGLYDERSITVEGQAALRNADRAYAEFYTSRLIGTTIPDLESYHDVEIEVRDRA
GVEQHPEDILEAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVVHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDANRADGLHTVVYLDIKVGHERTDED
EYMTADVGAELLAEEYPELVGVVVARAGSPDPLVEAGTIIDLADREFGEPLHLLVIPGEC
HLLEADALVELAGVERDVLDVT
>A0A101XGC2|diphthine synthase|EC 2.1.1.98|Thermocladium sp. ECH_B|TrEMBL
MGLLYIIGIGLHPGHISLEALNAMRSSNEVFIELYTSKLPQYAEDELVKLIGRRPLTLSR
HDIENNSGEXVMSALASSEAVSLLVIGDPLMATTHGALAVEAVKRGHKVRIINSVSIVCA
AFSQAGLSPYKAGPIATITYERLGYRSRRHIDVMLDNMRRGLHTLLLLDINDKGEFMEAS
YAAQLVSSDLRERGLDASRFMAIYLARVGWSTQKIVASTIDSPPDMGETPHSIIVPGSLN
AIEEEFLLNVLGADEKLVKKYMDFIKEVMEGKGLGAASA
>A0A7J4Q6L5|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MTETSLPAGLWLVGLGPGNLDYMSKYANDIAKSCSKRYLEGYTAILPPKQEEKLESLIGK
WERMMRPDIENPEELLKMAKEIPVALLIVGDPMQATTHIDLEARCEEMGINFNVVPGITA
TALAVSLSGLQSYRFGRQVTIPFSYGEYLPHSPLEMICKNYENNLHTLVLLDLDPTGMGV
NNPKPMKPDEAISLLARMAGKILEETSTFEILKKPVDEWDGILLTDISMVEQKVTAGNLS
QLSKLKEGWIHCMIIPSNMNDNELEAFERRKNC
>A0A133VF94|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA261O19|TrEMBL
MLIFIGLGLQGKGLTLEGLEEAQNADRAYVELYTSLIPDLDLDALSEKIGKKIKVLERED
VEEHPDEILETAKSEKVAFLVPGDPMVATTHVDLRLRAEKAGIETRIIHGASIEIAAPGL
AGLQSYKFGRSATIPLPEKPSETPYEVLVQNQEDGLHTLLLLDIEAPEERYLTANEAMEI
MLDLESKGGKNVFTQETLVAVIARAGSEKPTVKAGKVGDLIDFDFGSPPHVLIVPGKLHF
LEAEALQVFGGAPEEVEGYVE
>A0A1V5QLI4|diphthine synthase|EC 2.1.1.98|archaeon ADurb.Bin336|TrEMBL
MLYLIGLGLKVNHLTLEAIETIKKCDNVFVEVYTSQYAEGVIRELKELTGKNILELNRVE
IEQKFESALLSAGKNNIGLLIFGNPLTATTHIQLLLDAKEKGIKFKIIPGISITNMVAES
GLDEYKFGRTITICYHTKGFEPESFYDQLKENQKMGLHTLALLDIKKNQIPQMMMNSKEA
IEVLEKIAEKRNEHLNLNYIALIGMSSEKQKIIVGKEEIINSKEIFEIFPQTLIIAGKLN
EKEKEVIEKLYNKKIE
>A0A8J8D8B6|diphthine synthase|EC 2.1.1.98|Thermococcus sp. M36|TrEMBL
MAIYFIGLGLYDERDITLKGLETARKCDLVFAEFYTSLLAGTTIDRIEELIGKPIRRLTR
EDVELNFERIVLKEAREKDVAFLTAGDPMVATTHSDLRIRAKQMGIESYVIHAPSIYSAI
AVTGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENMERNLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGQGVFTPDTLVVVLARAGSLNPTLKAGYVRDMLSEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPEEILEGV
>A0A843D257|diphthine synthase|EC 2.1.1.98|Methanocorpusculum sp|TrEMBL
MLTFIGLGLFDEYDVSVRGLDAIRNADTVFLEVYTSVLMGSSIERLEEYYGKKITPLYRE
DVEIHSDKIINAAKEGDAVFLTAGDSMVATTHSDIRCRCAEAGVETKIIHGASITTAVCG
LSGLQNYRFGKSVSVPFPYGKWFPMTPIEVISENLKNNLHTLVFLDIQKDKERYMKVSEA
VELLEEQARRVGAKIPVYIGIARAGSPTPVVHAGDAEEMMQFDFGGPLHIMVVPAELHDM
EREYLERFAGLC
>A0A523AXU5|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MMLIFVGLGLCSHKGLPLRGLELARDSDWVYMEHYTSLLPELDLRELEGWVGKPVKVVDR
QTLEENPEEILERARKGKVVLLVPGDSMVATTHVDLRLRAEKRGIPTLVVPSSSILSAAP
A
>A0A7C7YM49|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MLLAPSTGGVRLILADDDSGIFLIGTGVGDPSMMPVKGVELAKECEYRFLEGYTSLLGEN
GMAKLQKMVGKFEILRRSSIESPSRIIEMAKKTKVAILVVGDPLQATTHADLILHAIENN
IPYKIVHATSVTTVVSGGLGLQSYKFGRQVTIAFPMGDYLPTSPIEMACENYENGLHTLV
LLDLDPTGSGEVEPTPMTPKEAVGIIQESVRKLKEDPPEYLIEELLEKDDLGAIIKCIKI
NNRLQTPVEDWQAILCSNLGTENEEIVYGKLSSISRCDGEGIHCLVIPANMHQMEEKALY
AMHNKV
>M0L6I5|diphthine synthase|EC 2.1.1.98|Halobiforma lacisalsi AJ5|TrEMBL
MLTFIGLGLYDERSITVEGREALRNADRVYAEFYTSELIGTTIEDLEAHHGVEIEVRDRA
GVEQEPDDMLEAAASEDVAFLTAGDTMISTTHVDLRLRARDRGIETRVIHGITAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPGSVTDTLEANREDGLHTVVYLDIKVGHELTEDD
EYMTADVGADLLAEEYPDMVGVVVARAGSPDPLVEAGTMTELADREFGDPLHLLVVPGDC
HPLEADALVELAGADREDLEIV
>A0A7J4QJK4|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLIGLGLFDANDISLRGLTAVKSCSLLFLEGYTSKLSCPVTELEKLYGKKVTMCDRAM
VEQQGEELIVLPAKHADIAFLVIGEVFSATTHSSLFLDAKKHKVNVQVIHNASVLTAVGV
TGLELYKFGRVASIPFHHADVTSPVEVMKQNQRMGLHTLFLLDIEPSIERYMAAAEAASY
LVGRGIPGDTKAVVCGALGSAAPRIRYLSLAEIKDLNVQVFPQCLIIPGRLHFMEEDMLS
LFGQEQ
>A0A3G8QXI4|diphthine synthase|EC 2.1.1.98|Haloplanus aerogenes|TrEMBL
MLTFVGLGLYDERSITVEGQDALRAADRVFAEFYTSRLVGTTVENLERHHGIDIEVRDRA
GVEQHPDPILDAAESEDVVFLTAGDTMISTTHVDLRLRAVERGIDTRVVHGVSAAQAASG
LTGLQNYRFGKAVTLPFPRAHGGGDVPASVVESVEANRDRGLHTLVYLDIKVDDGRGDDA
GETYMTADVAAGLLATAWPDRLAVAVARAGSPDPVVVADRLSALATHEFGDPLHLLVLPG
DLHHVEADALRTLAGAPADLVDPV
>M1Q5T2|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei Tuc01|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A8J8E1M6|diphthine synthase|EC 2.1.1.98|Thermococcus sp. GR7|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELQFERIVLSEAKGKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAI
AITGLQVYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGEGVFMPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGKQPHVMVVPG
RLHIVEAEYLVTFAGAPRKILDEV
>A0A662PVP2|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MPIHLIGLGLGTTEYLTLGALEVAERMDELLLDTYTSWIHPDLMEYLEERFGEKLVKADR
RMLEEGIEKLVERAEEKEIGILVPGDPLIATTHISIVLEARRRGIPAYLTYGVSIISASG
SASGLQAYKFGRITTVPRDGVGVETCYRVVAENLEKGLHSLILLDTADGGLRIPDALKML
MRVEDEFGYGIFDRESLVICLARIGSSEELRWAGRVSDALKLDYPPPPHLIIVPGELHFA
EAEALKEILGADEDLIESYRPPRYERDRVRSYILKVERVLEEIRIMVGLEKVVDVIEIVK
SYLEDSKKFLENGEVFNAVAAISYAEGLLDSLRNVGYVDFEWPRT
>A0A5N1L3S9|diphthine synthase|EC 2.1.1.98|Haloarcula sp. CBA1130|TrEMBL
MLTFVGLGLYDERSATVVGRDAIRDADRVFAEFYTSRLIGTDLETLADTLDTTIEVRDRA
GIEQDPEPILAAAESEDVVFCTAGDTMVSTTHTDLRLRAEDRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASHAAALLSEPLPDTLGVVVARAGSPDPLVVADTLDELAAQTFGDPLHLLVIPG
SLHPLEADALESLAGADLE
>A0A063ZBK4|diphthine synthase|EC 2.1.1.98|Methanoculleus sp. MH98A|TrEMBL
MLTFVGLGLYDLGDISVKGLEYVGNADAVFLEAYTSRLMGTDVAAMEAFFGKEIRVLGRE
DVEQNPREILDCAAAGRVAFLTGGDPMVSTTHADLRMRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPIETIAANLALNLHTLVYLDIQNDRYMRVPEAIA
VLEEMAAKRGIEPPALYVGIARAGSEHPVVAAGSGANLKETDFGPPLHILAVPADLHPME
REYLETFAGL
>A0A1V5TPK4|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon ADurb.Bin253|TrEMBL
MLYLIGLGLNEKSLSKEAIEIIKRCKKVYLEDYTVDFPYTHQALIDEIGKKFVTADREKV
ESLEIVDEAKKMDVALLVYGSPLTATTHVTLIEEAILSGIKYRIINNASVLDGIAETGLQ
VYKFGKITSLPEWKKSYEPDSFMEIVKENQSIKAHTLLLVDIGLDIKKAIEQLEKAAKKH
NFKLFKLIICQALGTKKQKIIYKDIEKIKEFTNVQKPYCIIIPGELHFMEKKMLEGFS
>A0A8B3S3L0|diphthine synthase|EC 2.1.1.98|Candidatus Argoarchaeum ethanivorans|TrEMBL
MLTFIGLGLCDEKDVSLRGLEAIRSADNVYLECYTSLFTGTSIKKLEKLYGKKVHLLERE
DVETNNWWLKDAIDQSIVFLTGGDAMVSTTHIDLRLRAKKLGIGTQIIHGASIISAVCGL
SGLQNYRFGKSATIPHPYTRKEKIIRSHTPYDTIKINQKNNLHTLIFLDIDKNIGCMSIK
EGIELLLQVEEEIGGEAISNCIGVGIARAGSFAPVVKADYLENLKHTDFGDPLHILCIPA
NLHFIEAEALIAFADAPGNILNHHKDSLCQDSVSENHAH
>G0HMH0|diphthine synthase|EC 2.1.1.98|Thermococcus sp. (strain CGMCC 1.5172 / 4557)|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCDLVFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EEVELHFERIVLSEAKEKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENVERGLHTMLFLDIKADQNRYMTANE
AMEILLRVEEMKKENVFTPDTLVVILARAGSLNPTLRAGYVRDMVGEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A3A5UYU3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MAAGLILIGMGPGGISGMTRAAIEAAKNADYRRYEAYTALWSNEDLEALEAEIGDIQRVM
RPEVEEPVELLQLAKSNIVALLVVGDPLQATTHVDLQLQAQEAGVECSVVHGVSITGLVT
GAVGLSNYRFGRQTTLTYPYGGWVATSPLEVIALNKKQGLHTLALLDLDPTGEGVGGQRP
MQPADAKDSILRMGSKLLENLDNYSKDTPFDLLKCESYSEICEDLSSLMVVLCSDMGTEK
QSISYLSVDDLSNAKNGGLHCLIVPASPSDVEISALSRWSKK
>A0A3A5VHY0|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MDEGRRMATEDISPGLWLIGIGPGDLGHMTERAKSIAKGCSKRYLEGYTAVLPKDQEDLL
EAEVGTWERLMRPSVEDPGGLLDEARDKPVALMVVGDPMQATTHIDLEARCMEQGVSFEV
VPGMSATSLAVSLSGLQSYKFGRQVTIPYPYGQYLATSPLEMINANRNSGLHTLVLLDLD
PTGMGFDLPTPMSPEQAVSVLERMSKRSQESEAREGIDADVREWEGILLSDIGTSSQRVS
SGSLDELSAIEGGYVHTFVIPSNMSDNEKEAFCRRKES
>A0A7J4TKV4|diphthine synthase|EC 2.1.1.98|Methanobacterium subterraneum|TrEMBL
MLYLVGLGLYDEKDISLNGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINILRRE
EVEEDNLPIKQAENKNVAFLTAGDPLMATTHSDILMEARRNGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEQNYFPHSPYQVIRENKKMGLHTLVLLDIQAHRDYYMTANEGL
EYLLRVEEERKEKIMEENTLAVVIARAGSPEPLVRADRVDKLTGEDFGGPLHCIMVPGDL
HFLEAEGLVVLGNAPEYILEE
>A0A7C7Z0S3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTNLESGLWLIGLGPGDLSSMTTAAIETAKACKYRFLEGYTALLPLDEEPKLTNMVGEYE
LLMRPGVENPDELLQLASESSVALMIVGDPLQATTHVDLQLRAKAAGINCHVIHGISITT
IVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNLQRNLHTLVLLDLDPTGMGVDE
QKPMSPAVAVDVLRRSADKIGENIEQWKIVLCSDMGRPEQRIFHGTLDEVQSINDGSIHC
IVIPGRLDELEVEALTRWN
>A0A846NGE8|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGLNDENDLTLKAIEIAKKCECFIELYTSVWKGSLDNLKEIIKKDIKILNRADL
EENLELFIEKTKENDVALFVPGDPLAATTHIDIVYEAKRKKIPVKIIHNASIFSAIGEAG
LQLYKYGKVATIPLSGKIKNVKDALKRNKRLGLHTLLLLDIDLENNIFMKVADAIKILLK
KKVIKETDQIIAFSNAGGDSKLFYDSARGFKMKHIESPAVLIIPGRLHFREKDFLEVI
>A0A497SBI7|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLVGIGMEEKDLSLKAIEAMVNSQKVYIESYTSKWLGFKEDLEKLTRKKIETLDRKDM
EEGVRKILKEAKERSVAILVPGDPLTATTHIEVILSAKKDDLPVKIIHAPSIFSVVAETG
LQIYKFGETVSLPRPRENYKPVSWMDKIYKNLEHGLHTLVLLDVEPQPMTIKEAIKIIKE
SDEKKLLNDKKIIACSCLGTEKRLIRCDVIENLIKCSGDFDTPACIVIPGNLHFKEEEAL
KMWSE
>A0A7J2U012|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLVLAGLGISDEKGITLEELEEARNSDLVFLELYTSIWHGSIKNLERIIGKEIQILKRKD
LEEEVHKILKLASHKKIVIFVPGDPLVATTHSSIILECMKSGIKFKVIHNSSIVSAICET
GLHIYKFGQTVTIPLRERIIEANSIINAIIENKRRGLHTLCLLDVDVENNRYVEVKEAVR
FLLENRVIDEDEKLVVGCCLGSVQKRILWKKASEVLLLNLPLPAIIVIPGNLHFSEREML
EKL
>A0A7J2TY71|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLVLAGLGISDEKGITLEGLEEARSSDLVFLELYTSIWHGSIENLEKIVGKEIQILKRKD
LEEEVHKILELASHKKIIIFVPGDPLVATTHSSIILECMKSGIEFKVIHNSSIVSAICET
GLHIYKFGQIVTIPLRERTIEANSVINAIVENKRRGLHTLCLLDIDAESNKYVEVKEAVR
FLLENRVIDEDEKLVVGCXLGSARKKILWKKAREVLLLDLPLPAVIVIPGSLHFSEREML
EKL
>A0A8F5BQL8|diphthine synthase|EC 2.1.1.98|Saccharolobus shibatae B12|TrEMBL
MSILSLVGLGISKKFITESAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGEKTFIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNRERGLHTILYLDLKSEKAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVAVTVEEASSYDFGNTPHIIIIP
GNLHYMEADAIKWMLTS
>A0A524J6H5|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccus sp|TrEMBL
MVRRSGKLSFIGLGLHDENGITLAGLDRIRSADVVFAEFYTSKLSEGALERLSAMTNKEI
IALGREEVEDGERILKEAGEKKVALLVAGDPMTATTHIDLRLRAHKASIDTEVIHGSSAL
TAVPGLLGLQHYKFGRTTTLPFPQEGYSP
>A0A1V4ZFY4|diphthine synthase|EC 2.1.1.98|Methanoregula sp. PtaU1.Bin006|TrEMBL
MLTFVGLGLFDKTDVSVKGLACIRQADHVFLESYTSCLMGSSADDLAAYYNKPVHRLFRE
DVEQHPDHLLDLAQEDQVVFLCAGDPMVSTTHADLRIRAAERGIRTAIIHAASIASAVCG
LSGLQNYRFGKSCSLPFPQKNWFPTTPFDVITANLASRLHTIVYLDIRTDRFMTIPEAVG
LLEHMAHDRQAEIPLYVGIARAGSDDVMVRAGSAEKIRSQDFGPPLHILVIPAELHDMER
RYLEMFAGL
>A0A842L602|diphthine synthase|EC 2.1.1.98|Thermococcus sp|TrEMBL
MSIYFIGLGLYDEKDITLKGLEIAKNCDLVFAEFYTSLLAGTTIEKIEQQIGKPIKLLSR
EDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSIYSAI
SITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYMTANE
AINILLQVEEMKKEEIFTEDTLVVILARAGSLTPTLKAGYVREMIKEDFGKQPHILIVPG
KLHIVEAEYLVEFANAPKEILKEV
>A0A087S1H8|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote SCGC AAA799-P11|TrEMBL
MLWFVGLGISGFKSIPNEAINVLAKADMVYLEQFTSPISKSDLTKIKKATKGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALKG
LLETEKGQRRKVINSSTFAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIEEPFDNAEKTRKISAQMIEKYVPMVREALEEVEPYYKDQKEFQVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A100XYU0|diphthine synthase|EC 2.1.1.98|Thermococcus celericrescens|TrEMBL
MAIYFIGLGLYDERDTTLKGLETARKCDLVFAEFYTSLLAGTTLDRVEELIGKPIRRLSR
EEVELHFERIVLSEAKEKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMIKEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A843GCB6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGVEALKKVDKVYAEFFTSRLFGSNFEKIESIIGKDIIVLDRT
QVEEESIFLEEAKDMDVALIAGGDPLIATTHSDFLVECARKGIDFEVIHGSSILSSAPAI
SGLQAYKFGKVTTIPFPDLEYNYFPKSPYIAIEENLKMDMHTLVLLDIQAHKDKYMTVNE
GLENLMTIKDNLDHEGL
>A0A098E8W5|diphthine synthase|EC 2.1.1.98|groundwater metagenome|TrEMBL
MLYLVGLGLYDEKDISLRAIEILKSADEIYAENYTNFYHGNLKNIEATIGKNINTLKRND
IESGEILYEDALLKDIVLLVPGDPMLATTHSSIILDAEKRKIKVKVIHSSSIYSAIAETG
LMAYKFGRTTTIAFPYKDTIPSSPYKILGENSERNLHTLMLLDIDVEGDKFLSITHGLEI
LLKLEEDAKENIVRKATFVCCARLGSDAPIIKAVKGTDIEKILNFDFGNPPHCIIAAANL
HFIEEEMIARFY
>A0A256XVK8|diphthine synthase|EC 2.1.1.98|Thermofilum sp. (strain ex4484_79)|TrEMBL
MMGCIAFIGLGLYGLRDISIGAIEYLRRASRVFMEKYTSILPDFKKEELEVIIGKKIEVL
TRRNLEEESGEIIIESAKEGNVAFVSIGDPLIATTHISLMLSAIRENIKVLVFPSPSIIN
GVIASTGLHIYKFSRPVTLTFIEEKYKYYPFTAYSVLEDNLRRGLHTLFLLDIRISENRI
MNIKEAVNVLIELERIEKRQIIDEELTIGIGIARSTAPDECVYVDILRKLKKFDFGPPPY
TLVIPGLLHRTEIEALNILGKADKEKLLRWNQRIKSSFLGRI
>A0A7K4F8U6|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPIEAIDVLSKADIVYLEQFTSPIGKSDLTKIKNAIKGEFKPAKRW
LVEDGEEILKNAKRKKVVLLSYGDPYIATTHIELRTRAIEEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALDG
LIETEKGQKRNVISSDSYAIVASRIGFRDQLIISGKISSLKKKDFGKPPHTVIIPGRLHF
TESDALKILGQCIDEPFDNSSKTKKISKQMMEKYVPMVREALEEIEPHYKNQKEFQVILE
NAELYIKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A1Y3A835|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SD683|TrEMBL
MLTFIGLGLCDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A1V5IDG3|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ADurb.BinA087|TrEMBL
MLTFVGLGLFDLEDISVKGLDCIRTADTVFLEAYTSRLAGCTVEEMASRYGKEIQILSRH
DVEVDPDPLLELAATGRVVLLVGGDPMVSTTHIDLRIRARMRGISTRIIHGSSISTAVCG
LTGLQNYRFGKSCSLPFPHGSWFPMTPINVVAENIRQDLHTLVYLDIQDDRFMTIHEAVA
LLEEMAARSGGLIPLYVGIARAGSDSPIVRAGDARTLIATDFGPPLHIIAIPASLHVMER
EYLELFGGL
>A0A0E3SC13|diphthine synthase|EC 2.1.1.98|Methanosarcina horonobensis HB-1 = JCM 15518|TrEMBL
MLTFIGLGLFDEYDVSLKGLEAIREADLVYAEFYTSHLMGTTPEKMEKLYGKQVHLLSRE
DVEQQPEWLDNAKDKNIAFLTGGDTMVSTTHVDLRLRAKNLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVVSETPYDTIKQNSELGLHTLVFLDIDNEKGYMSV
NLALELLLEVERKRGEEVMNRAVAVGIARAGSEKPLVKADYAENLKNFDFGKPLHILVVP
GKLHFLEAEALVKLAAGPEEIMENIE
>A0A8D5U7S2|diphthine synthase|EC 2.1.1.98|Stygiolobus sp. KN-1|TrEMBL
MSLLKLIGLGLSSKFITQKAIDELSTSDFIYLDSYTSLSCDINEETVSTLLKKEVPIYRA
NRTLLENNFKNILSLLDEGKNVAIATIGDPMIATTHSSLVSEVKNRGHGYIIVPGVSVHC
YIISKSLLSSYRFGKSVTIVYPFDNKVDTTPYKTLKENQERNLHTIFYLDIRDNTPMNAV
EAINLLIKMEEIERKNVLSLDDPIIIGERLGCEDEEVVAMKVHEVFDYKFKPQPHIIVYP
SKSLHFMELEGLKCLMKK
>A0A1V6IQC2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ADurb.Bin023|TrEMBL
MLYLIGLGLSERDLSLRAFELLRKIVNIYVDTYTNYFDFDLLWLENELNKKIIPLSRNDM
EKNPTFLDIAKSKEVALLVSGDPLVATTHTDIILRANKMGVKTKIYHASSIYSAIAETGL
HIYRFGKTTSIPYPEENFFPKSFYDVIVQNKERNLHTMLLLDVKKEKNLFMNPKEAISIL
KEIDKNNNITDIIVISRISHENQKIIYGDIDKLIKFENEYYGPPPHTLVVPAKLHFAEEE
YLLSLAEIHKNSKNK
>A0A3N0A2I2|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp. H8|TrEMBL
MLWFVGLGVSGFDSVPARGIDVLARADVVYLEQFTSPVPERDVSRIRDVTGGKLVLAKRW
QVEDGAEILKSAKDGEAVLLSYGDPYIATTHIELRTRAAAQGTATGAIHASSALTAIVGE
CGLHFYKVGRVATIMGGESFATPYRTLYKNMAEGGHTILLLEYDQERDFFLDPSDALAGL
LEAEKGQARRVIGESTYCIIASRIGSEDQRITAGMISSLAGTDFGSPPHTVIIPGSLHFT
ESDALGSTCRCVDAPAGNTVEKISAQMIAKYVPMVRAALEEAKSMYAGKYDDVLENAEMY
IRDAEKFLADGHDEVAVLSIGYADGLVDALRMAGGLEPKM
>A0A7C3XHS6|diphthine synthase|EC 2.1.1.98|Nitrososphaerales archaeon|TrEMBL
MLFFIGLGLHGAKGIPLIGLDIAKKAEKVYLDVYTSPITKDEIDSLKDLIGNEIVRVGRD
FIEDGLEIINQAKQKDVALIASGDPMVATTHLDLRLRAEKYGIKTHVIHNSSILCALPGE
TGLHAYNFGKTVTLMKSGLTPSSTVYEVIHENLIRGLHTIILLEYDYSTGFFLKPNEALK
SLLNMERDFRQGIFDDETFVIVTSRIGSNSQLLHGGKIGSLIDKDYSEPPHAIIVPGKLH
FTEIDALKTLLKIDEDQITDNSSKVKSLAVSMVKRYAMNTRKALSKAREKSEAEKKNFDD
LFENIECYISDAERFLNMGKFELAILSIGYAEGLLDSLRFIKELEIEW
>A0A075LUB1|diphthine synthase|EC 2.1.1.98|Palaeococcus pacificus DY20341|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTTIEKIQEQLGKPITLLNR
EDVELNFERIVLKEAKDKDVAFLTAGDPMVATTHSDLRIRAKQMGIESYIIHAPSIYSAI
AVTGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENKEHNLHTLLFLDIKADQGRYMTANE
AMEILLQVEEMKKQNVFTQDTLVVVLARAGSLSPTLKAGYVKDMIKEDFGKQPHIMIVPG
KLHIVEAEYLVEFADAPKEILDEV
>A0A6G2KE63|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0678_bin_8|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A843LEI9|diphthine synthase|EC 2.1.1.98|Methanoculleus sp|TrEMBL
RCMRIPEAIEIIEEMAERRGVEPPALYVGIARAGSEHPVVAAGSGSKLKETDFGPPLHVL
AVPADLHPVEREYLETFAGL
>A0A1D2QJA6|diphthine synthase|EC 2.1.1.98|Haladaptatus sp. W1|TrEMBL
MLTFIGLGLYDERSITVEGRDAIADTDRVFAEFYTSKLIGADVTDLEAFHDTDIEVRDRA
GVEQHPDDILAAAESGDAAFLTAGDTMISTTHVDLRLRAEDRGIDTRVVHAPTAESAASG
LTGLQNYRFGKATTLPFEYAHGADGLPASVTDVLDDNRERGLHTLVYLDIKVGWNPRKKD
EAGEDEYMTASHAAELLADGYDDVLAVVVARAGSPDPLVEADRLSELAERDFGDPLHLLV
VPGDLHHIEADALESLADAPSDLLDVV
>A0A7C3RDF6|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus|TrEMBL
MLTFIGLGLWDVKSISVKGFEAVKEADEVYVEFYTSKLSSSIDEMEEFFGREIVELERSD
LEENSQRLIERAREKNVVLLVPGDPMVATTHSALRLEAERRGVRTRIIHGASIISAVCGL
TGLHNYRFGKSATVSWHRSETPVRVVNANRSIDAHTLLFLDLHPEPMKIMEAVDLLISVD
DTLKDFYAVGLARAGGEDPVVKCDKLEALKDIDFGEPLHVMVILARTLHFMEFECLREFA
DAPPELERLVA
>A0A4Q3MYT4|diphthine synthase|EC 2.1.1.98|Cytophagaceae bacterium|TrEMBL
FSATTHTDLALRCRQHDPPIKTRTLPNASILTAVGATGLSLYAFGQTISMVFFTDTWKPD
SFYGRVKDNNGLGLHTLVLLDIKVKEPNLEALARGRIVYEAPRFMTAAQCAQQMVEIEEL
RKEDVCGKDKLAVSVARLGSDGEKIVAGTLEELSSVDMGAPLHSLVLCGTNMHEMEWEYI
REFAVNQDKFDEIWKRDYAGKQH
>A0A257A320|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ex4484_162|TrEMBL
MKKGELVFIGLGLYDEKDISLKGVELVKKCDKIFAEFYTSVLTDDCIEKLEEMIGKKIEV
LNREEVEDGRVILEHAMDKKVAFLVGGDPLSATTHVDLRIRAKKQGVDTKIIHGSSIFTA
IPGLLGLQHYKFGRVTTLMFPHGDFFPKSPYEIIYENKSRGLHTLVLLDIDRENNRFMSA
NEGMKLLFDMEESLGKNLINDNLLVCVVARAGSDNPVVKAGRIKRLIREDFGSPLHTLVV
PGNLHFMEVEALISFAGLEKDELG
>A0A075HXV1|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_86_F11|TrEMBL
MFAGLGLNEKTITNEIIEEVKDADKIYFERYTSPPMPYNEYKFSFQYEQVGREFIENGRE
ILEQSKEGKVVLLTYGDPMIATTHMDLKMRASEAGIITKVLHNTSIITVLPGETGLHSYK
FGRITTLMAEAQIAPLSVYEVIYKNLLSELHSTILMEYNLDTMKYLDPNDAIKQLLEIEK
EQKKQVIDESTIIIIASRIGMNKQEIFCDNASKLIKRNYDKPPYTIIIPGKLHFTEIESL
QQLFGIQNITDNSANIKSKSTDMLEKYIPKAKITLEKIRKMTDNNVRYRDLFKNIEAYIE
DSERFRDEERFELAILSIGYAEGLIDALIFLGEVELEW
>A0A2U9IQL3|diphthine synthase|EC 2.1.1.98|Acidianus sulfidivorans JP7|TrEMBL
MSSLYFIGLGLSKKFLTKASIDAIKLADLVFFDSYTSISCDIDIEYLKKISGKDIILANR
NLLENDSNKILHFLDEGKSVAILSIGDSMIATTHVSLAVEAKNRGHKIVIVPGISVQCYI
ISKSMLSSYKFGRAVTLVYPYEGRLDMSTYEVIKNNINSNLHTILYLDIRDGKPMSAREA
IMYLLKMEEEKRENIITDNTWIIVGQRLGCDDEEVKSMTVKEALEYNFKDPPHIIIIPSK
NLHYMEVEAIKCLH
>A0A166SCY9|diphthine synthase|EC 2.1.1.98|Haladaptatus sp. R4|TrEMBL
MLTFIGLGLYDERSITVEGREAIADADEVFAEFYTSKLIGADVADLEAFHGTDIEVRDRP
GVEQDPEDILDAAESGHAAFLTAGDTMISTTHVDLRLRAEDRGIDTRVIHAPTAESAASG
LTGLQNYRFGKATTLPFEYAHGADGLPASVTDVLDDNRERGLHTLVYLDIKVGWNPRKES
ETEDEYMTANHAAELLADGYDDVLAVVVARAGSPDPLVEADRLSVLAERDFGDPLHLLVV
PGDLHHIEADALASLADAPSELLNVV
>A0A831LUN5|diphthine synthase|EC 2.1.1.98|Methanofollis liminatans|TrEMBL
MLTFIGLGLYDETDISIKGLDRIRRSDYVFLECYTSVLTGTTPEQMTELFGKEVGMLYRE
DVEGHPENFLELAKESDVAFLTAGDPMVSTTHIDLRIRAAAMGIRTEIVHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGKWAPTTPIEVIEQNIADKLHTLVYLDIQPDRYMRIPEAVR
MLEEMAAARGVSIPVYVGVARAGSGSPVVAAGTAAALAGVDFGGPLHILVVPGDLHLMER
EYLETFAGL
>A0A7J4FWK9|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYLIGLGISDEKDLSLRGFEILKAVDKIYAEFYTSSFSATVDDIEKLLDRKITILSRED
IEENLDETILREAYKKNIALLTPGDPMIATTHSALILSARKSGILTRIIHSSSIYSSIAE
TGLQIYKFGKTTTIPFPEKGYLPTSPYDVLKTNLDCEMHTLLLLDIRMTIDEATDILLKM
EKDKREGIIKEDILCIGVARLGSKDSVIKYGRLKDIHSYDFGKPPHALIIPGKLHFMEEE
FLDTFIL
>A0A2T9WTA2|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. SCGC AB-777_L09|TrEMBL
MGTLKLVGLGLSLKYLTPKALEELKNSDIVYLDSYTSVSCDISEEKLREKGINVTAVDRN
FIENNTKKIIDDLNNGKIVSIASIGDPVIATTHVSLLVEAKNKGHEVKVIPGVSVHCYII
SKSLLSSYKFGKSVTITYPINGKIDITPYNVLKENLERGLHTIFYLDIRDGKLMTAREAI
ELLLEMEKLEKGNIVNKDSLVVVGERLGCEDEEVVSLTVEEALNYKFIQPPHIIVFPSKS
LHFMELEGLKCLRQSRKE
>A0A7J3FPH8|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MMLIFVGLGLCSHKGLPLRGLELARDSDWVYMEHYTSLLPELDLRELEGWVGKPVKVVDR
QTLEENPEEILERARKGKVVLLVPGDSMVATTHVDLRLRAEKRGIPTLVVPSSSILSAAP
GLTGLQSYKFGRSATIPFRDHPSTVPYDTLVENSARGLHTLLLLDLRAEEGRYMTAGEGM
EIMLELEARMGKGVFTPETLV
>A0A497L0A5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRPRDPHPPQEAEAVSAGVSLISIGLRDERDLSLRALDEARRCDALYVETYTTKLDTTPE
RLAALIGRPVEPLPRSRMEEEADALLDEARRRRVGVLVGGDCLTATTHISLLLDARRRGI
PTRVVHGSSILTAVAETGLSPYKFGRTVTLPLPEKGPADTVLNAVAENLVRGLHTLILLD
LDAEADRHLTISQAIQILLDADRPHAFNPETLTVAVARLGSETATIRAGKASEIAVEDHG
PPPHTLIIPGHLHFLEAEALKTIGNCPDTALKGWKPRGEIDRLIEKYARSCRGAIDGLRL
GALPREIGEKEVKDLIEHAERYLRDAMYYASERRATALSSVCYSEGILDALRLLGLVDFE
W
>A0A523T9Y9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MNELVFIGLGLYDEKDISLRGLEELKEADTVFAEFYTSLMPGLSIRKLEEMTGKAVNVVS
RRVLEEEEGQQLFEAAKKGKAVFLVQGDPMIATTHVDLRISAEKQGIKTRVIHGASVVSA
VRGISGLQNYKYGKAVTIPFSEQGFVSETPYNVIRENKKRGLHTMCYLDINAEEKKYLTI
KEALQTLLELEKLKKEQLVTSRTLVIGVARAGSYQPVVKAGYLEEVINYDFGVPPHTLVF
PGNLHFMEAEALIALAGAPQEIREMSE
>A0A497NVE2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRVCFVGGHEGLGELIFVGLGLFDENDISLRGVEEAKNADIVFAEFYTSLLAGLSLHRLE
EIVGKRIIVLRRRDLEDECGESILRAAENGKAVLLVPGDPLIATTHIDLRIRAEKRGIKT
RIVHSASIVSAAMGLSGLQNYRFGKSVTIPFPMNGRISRTPYDVIAENKSRDLHTLCFLD
LDVEGGRFMRIREALEILLSLEDDIGEGILNLESLAVGISRAGAKDGIVKAGSIKELLNF
NFGDPPHTLIIPSDNLHFMEAEALSVLADAPKWVREMIK
>A0A2R6H976|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_4_69_34|TrEMBL
MLSFVGLGLYDERSITLEGRDAIRSADRAFAERYTSTLAGATIDDLEAHHGVAIALRDRA
GVERDPEPILDAAETGHAAFLVGGDPMVSTTHVDLRLRAHERGIETRVVHGTTARTVAGS
LTGLQNYRFGKATTLPFPRSGRRASGPGGEGSDDPADAGPDDAVDDGPVGTRHDPGTVPV
PDSVLGAIGENRERGLHTLVYLDIDAERERYMDASAAAGRLAAPLDDPLGVVVARAGSPK
PVVAAGRLSTLADRAFGGPLHLLVVPGELHHLEATALRELAGGPAELL
>A0A482T0H1|diphthine synthase|EC 2.1.1.98|Haloarcula hispanica|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESDDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDDS
DDTYMTASKAADMLSEPFPDTLGVVVARAGSPEPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A327HPH8|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MMGSGAGRFTMTDEGESVGLWLIGLGPGDLGLMTRSATEAARSCDKRYLEGYTAVLPANQ
EAALEGVVGSWERLMRPSIESPSVLMEEARVSAVALMVVGDPLQATTHVDLETWCSESGV
KFHVEPGISATSLAVSASGLQSYRFGRQVTIPYRYGEYLPTSPLEMIEGNLSRGLHTLVL
LDLDPSGMGVDRPTPMKPKEAVSLIESMAEKCVEEEVGGIFTESSIREWDGFLLSDLGTD
SQRVLSGSLGELSNAEGGLVHTLIIPANMSDNEKESFERRRPHR
>A0A534M262|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLHDEKGVTLRGLEDARGADVVFAELYTSTLAGASLESVERLVGKKIRILG
RAEVEDGHTILAAAAGQRVAFLVGGDPMAATTHVDLRLRAASAGIPTRIVHGASILTAAA
GVLGLQIYKFGRTTTIPFPSEGFGPTSPLEVILENRSAGLHSLVLLDLREDGTFLLAGDA
IGLLLQMAAKIGTAEIGRRMLTCALSRVGSREALAVAGPLGELPARDLGRPPHCLVIPGS
LHFLEKEALIAFAGAPRDFSEGPSRVPRGGRSART
>A0A1B8X1Q6|diphthine synthase|EC 2.1.1.98|Methanohalophilus sp. DAL1|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNAGKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEINIAFLTGGDTMVSTTHVDIRLRAMEMGIETCLIHGASIVSAICGL
TGLQNYRFGKAATIPYPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMDKGYMTV
NQGIELLLQVDEKRGENLIKGSIAVGIANAGSEKPIVRADFAENLESCDFGSPLHIVVIP
ADLHFVEAESLIKLADAPESILEEGDIN
>A0A1Q7YU12|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_20CM_2_53_14|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDSVAFLVPGDPMIATTHISLRLSLSKAGIGSRIIHGPSIMSA
VCGATGLQSYKFSKTVTVPYDPPLPASILETISDNYGRGLHTLLLLDVEADLNKQLTIAD
ALAKITSANPSLETRLAVGVARLGSRDEKVKASRIGRLVTEDFGGPPHSIVVVGRLHFME
TEALRIICGAQDSDLRENS
>A0A7J4L1F9|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MFYLVGIGLKPEHLTLEAQNILKECSEIYLERYTSQYSEGSFEFLEALLGRKVILTDRHE
VENEFGKKLQKAKSGNVALLVFGNALTATTHIQLLLDCRKFKVPFSFIPGISLTNFIALS
GLQEYKFGRSVTIVQPEANYSPDSFYDFIKENQKLGLHSLCFLDIKQEKKKLLSIKEALG
ILEVIEGKRKDSLLKKSVLVGIAGAGSSKMQIKAGSVNDLKRFSFNSFPQALIICGSLSE
KEREALNALSV
>A0A482T8T1|diphthine synthase|EC 2.1.1.98|Halogeometricum borinquense|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEDLESYHDIDVAVRDRA
GVEQHPEDILDAAEDEHVVFLTAGDTMISTTHVDLRLRAVERGIDTRVIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPKSVIDSIEANRERGLHTLIYLDIKADRDEYMSG
DYAAEMLADGWEDVLGIVVARAGSEDPLVAADRLSELAERDFGDPLHMLVIPGDVHHVEA
DALRTLGGAPDEVLSENEV
>A0A2Z5PF29|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis KA1|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISDETKVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>A0A523AFU4|diphthine synthase|EC 2.1.1.98|Archaeoglobi archaeon|TrEMBL
MLFLIGLGLWDSKDITLRGLEIVKNSDAVYAELYTSKLGVGVEELEKFFGRKIEVLKRED
LEDKSYRILERAKKEDIAILVAG
>T0MAA7|diphthine synthase|EC 2.1.1.98|Ferroplasma sp. Type II|TrEMBL
MLNIMGLGLRGVKSLTLEEADAIRESEIVYFETYTSISPQDTINSIPSLTEGIVKPADRK
MVETDKEIINEAKNKNVTLLVTGDALSATTHNELRMEAKKSGIEVKIFENASIITAFISR
TGLFNYKFGNIVSMPFVYENFFPVSVYERIYTNYSNSMHTLLLLDLKDGKTMQVCEALSI
LQKMEEKKGKGLINSGIIVIAGIGIASENERIIYGTLEKIMEYNPQGSPASIIIPSRMND
VENEFLNTFAMKI
>A0A1G8U017|diphthine synthase|EC 2.1.1.98|Natronorubrum texcoconense|TrEMBL
MLTFIGLGLYDEHSITVEGQEALRNADRVYAEFYTSELIGTSLEDLESHHDIEIEVRDRT
GVEQHPEDILEAAETEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVVHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGAEGLPASVSNTIDDNRADGLHTVVYLDIKVDNEAATNR
LETDETLEEYMTADVGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMTELAEREFGDPLH
LLVVPGDCHLLEADALVELAGADRDALDIS
>D7DB79|diphthine synthase|EC 2.1.1.98|Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)|TrEMBL
MLYFIGLGLSINHLTLEAIDALRNADKVYIDTYTNIVPDFSLDKLVGLVGEEKEFVMAKR
ELLEGKNIYYIVEEASKKNIAILVPGDPFIATTHDAIRVEALRRGVKIRVVNGLSIYSLA
PSRTGLQAYRFGKTVTLVYPDYFKPYSTIETIYDNLDRNLHTLLLLDLKIEENKAMTIPE
AIDILIELDERRVLENIIGVGLAQLGSSMEKIVADRLADLKKYAYPSPPHSIIIVAKPHP
VELDNLYYVCGLPEHLYRRYSVSKTYP
>A0A4Y3G1Y1|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLVLIGLGLYSEKDITLRGLEEARSSDYIFAEFYTSVMPGLHLDRLEKIIGRKVRLLSRS
DIEEEGEKVILERAKKSKVSLLVAGDALISTTHVHLLLDARESEIEVKVVNNASIYSAAP
SLAGLHNYKFGRSASIARPEERFFSETPYTTVKANMKMGLHTMLFLDIKVEKSGTYLMHA
KEALEILLKLEDRKKEGVINTETIAVVVSRAGAPEFKLKAGSIRKLLEEDLGRPPHTLII
PAELHFMEEEFLRAFASLPEE
>A0A7C1RFR8|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYIIGLGLNADGISKYGLEIVKRCKRVYLENYTVDFPYTKEELAHVIEKKLLDAGREKV
ESLELVDEAQKMDVALLVYGSPLTATTHISLIEEAKRLGIRYKVICNASILDAVAETGLQ
LYKFGKTASMPKWDEKKNFTPDSFMKIVQENQSMKAHSLILTDIGLSFPKALEQLEKSAK
IHKISLKKIVVCQRLGTKNRKIIYKDVGELREYDGVKSPYCIVIPSKLHFVEKEVLEGR
>A0A662VFT2|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLIFIGAGLSINHLTIEAIEWLKKADKIIIDSYTNIIPDFSIDKLFKIIGTRKDVIIANR
SMLEGISIKKIVEEAQKLNLAILVPGDPFIATTHDAIRVEAIKHGVQVKTINGLSIYSLA
PSRTGLQAYRFGKTVTLVYPEAFKPYSTIETIYDNLSRNLHTLLLLDLKLEENKAMTINE
AVDILMDLDEDRKLNNIIAVGLARIGCKDEKIQADRLSRLKKYGFPPPPHSLVIVAKPHP
IELDSLKYLCNLPDEIYRELLSSRKYP
>A0A833E4A5|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDERDMTLKTLEYARKADKVYAEFYTAALTGTTLDRIEGVIGREIIPLTRE
DVEYRGYKLVEESRDKLVVLLTVGDPMVATTHVDLVIEAKKRGVDVGVINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYNVIRDNLKMGLHTLCLLDIQSDKNRFMSANEGL
KILLELENRRKENVLNEDSKVVVLARAGSLKPKIVYGKIRDLIDYDFGPPLHSIIIPGKL
HFMEEEALKYICEHVP
>A0A5E4JFP8|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGLGLKPSHLTIEALEAIKKCDSVFLETYTSQYAQGFTKDLKELIGRDFLELGRKG
VEENFESALLSASSNNIALLVFGNPLTATTHIQLLLDAKEKGIKTKVIPGISITNFVAES
GLDEYKFGRTVTICYHAPNYEPDTFYKQILANQKIGLHTLCLLDIKKDETPQRMMNAIEA
IEVLEKIAGKEKKKTVKKKGFEYVALMGMGSEKQKILNGEKNIREFKEIHYIFPQSLIVL
GKTNEKEKEALEKLH
>A0A836W8E0|diphthine synthase|EC 2.1.1.98|Ignisphaera sp|TrEMBL
MKELRNIFPRRVCLADSMLKLIGLGLSADLITLRSLLELMKCKRILIDSYTSMWFPSLDS
LIDILRKLSKHCVKVYRESLEGKAINEIIAMSREEDVCIAVAGDPLIATTHSSLIVEAFK
QGVEVEVIPSTSILSIAISLSCLQAYRFGKCVTLVKPRNGIVFEYPIYVIEENRNRNLHT
ILLLDLDVAQGYYMTPKEAANLLVKLQERLGKRVLDYDDYLIILGAIGSEYGSIQVLKLY
ELIEGEERYNTPPYTLIIPAKKLHPMEEECIEMLRLRKLYFRPRISMTDIYKVIRVLSSD
YE
>A0A256HL28|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Hd13|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVDELEAYHDVEIEVRPRE
GVERDPEAILSAAAEGDVAFCTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWRDELAVVVARAGSPEPVVAADRLSALSEREFGDPLHLLVI
PGDLHHVEADALAGLAGAPSELVEE
>A0A7K3ZZU0|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLTFIGLGLYDEKDISVKGREAIAAADRVYAEFYTSRLMGTTLCRLEAFHGKKIHLLNRS
QVEVDPTWLEQAKDEDVAFLVGGDAMVSTTHLDLRLQAMRLGIRTRLIHSASIVTAVSGL
SGLQNYRFGRSTTIPFPYMARSKRIVPETPYRVLQENLARNLHTILFLDIQMEPEERYMT
AGQGAALLLEMEEAAEEMLPPRVLGIGVARAGSDDAVIKADLLSRLRDIDLGGPLHILIV
PARLHFMEAEALRFLAGAPEDALIGAD
>F4G0A1|diphthine synthase|EC 2.1.1.98|Metallosphaera cuprina (strain Ar-4)|TrEMBL
MSNIYFIGLGLSKRFLTNASIDAMRKSDVIYADVYTSISCDITEDLLRQLSGKDVIPGNR
DVLENREKEIYKLLDTGKNVGVAVIGDPMIATTHVSLAVGARQRGHTVIVVPGMSVHCYM
ISKSLLSSYKFGKSVTVAFPALGKVDVTPYKVIKSNRDQGLHTMVYLDLKEGGVMTADLA
LKYLVQMEMEMKQNAISQEDLVIIGERLGCDDERIRSMTISSAINEKFGKPPHIIIIPAR
NLYDMELEGLRCLI
>A0A1I5NGR4|diphthine synthase|EC 2.1.1.98|Halolamina pelagica|TrEMBL
MLTFIGLGLYDERSITVEGREALAGADRAFAEFYTSRLVGTTVEALESFHDIGIDVRDRA
GVERDPAPILDAAEDEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVSAQSAAAG
LTGLQNYRFGKATTLPFPGAHGGGDVPDSVIETIEANRERDLHTLVYLDIKVDDPTADAA
GLGEDERYMTGDYAAGLLAEHWADELGVVVARAGSPEPVVAADRLSELADREFGGPLHLL
VVPAAPHHLEAEALEELAGAPTALLDEN
>A0A7C5DGH3|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MIGLGLWDEKDISVKGLEAVRRCDKLFFEAYTSKLGVSVDKLEGFYGKRIIVADRSMVET
QTNKILSPAKNSNVAFLVVGDVFSATTHVDLYLRAKKEGVDVIVINNASILNSIGVVGLE
LYKYGRTTSIPFHNKHVITPYDVVKQNKAQKLHTLLLLDIDAEHNSYMTIREAIEYLLGV
EDKRKEGVFTRATRCVGVARLGSENPEIIYGTADELLQLDFGEPLHTLIIPSELHFIEEE
ALNQWRADKRKIRGES
>A0A3M1NL10|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALYLIGIGLNDEQDISLKGLEAVRKCDSVYLENYTSLLQCPVERLEKLYGKKIILADRE
LVEKKAEETILKGAKDKDVALLIIGDVFSATTHTDIFLRAKKLDIPVNVIHNASVLTAVG
ETGLELYKFGKTTSIPFKEKGFEPETYYDVLLENQHLGLHTLFLLDLRPAEKKFMTIKEA
IQNLLDIEDKRKEKILTEKTLCVGCARLGNKNQKIIYGSAEELMKLDFGKAPHCLIVPGK
LHFMEEEILKRVWGFKGAVHL
>A0A2D6LH34|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGTGLNDERDITIKGLETIKSCDEVYLENYTSLINCSISDLEKYYGKKITIVDRK
FVEQTDELVNSSKTKNIALLVIGDPFGATTHIDLMLRCKKESVGFKIINNASILTAIGIT
GLQIYKFGKTTSIPFPDKNFRPETSYEVIKQNKILGLHTLVMLDLKPEQDKFMTVSEAIN
ILLEIESRKHQNVFTKETFCVGVARIGSDDFVIKSGIASDLLKEDFGKQPHSLIVPGELH
FVEEDALKMWK
>A0A1H3HU13|diphthine synthase|EC 2.1.1.98|Halobellus clavatus|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAAAEFYTSHLVGATVDELSAHHDIDIEVRDRA
GVEQDPADLLDAAEDEHVAFLTAGDTMISTTHVDLRLRAIERGIDTRVVHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPGSVVDSIEANRERGLHTLVYLDIKAERDEYMTA
DVAAEMLAEGWQDGLGVAVARAGSPESTVAADRLSALADRAFGDPLHLLVVPGDLHHVES
DALATLGGAPEDVLRENEL
>A0A6B0ZZU0|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0666_bin_15|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A075I4G3|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_10_H08|TrEMBL
MLWFVGLGISGTRSVPIEVVKIIQEADFVYLEVFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKVSKNSIVVLLSYGDPYVATTHIELRTRAKLENIETNTIHSASVITSMIGE
AGLQFYKIGRIATIMNEKIHNNSIHYHL
>A0A7J2MPR1|diphthine synthase|EC 2.1.1.98|Methanomicrobia archaeon|TrEMBL
EKDFIVEEAEKENIGFLVSGDPLAATTHIDLVLRAKKRNIDVKIIHASSIFSAVSETGLQ
LYKFGKTVSIVYPEEKFFPKSFYDTIISNKERGLHTLLLLDIKAENKRYMNPNEAFEILE
TVDKNKIIKKIVVVSRLGRDDQRIIYGDINELKSCSYGDPPHCIILPGELHFLEEEFLNY
FKVKK
>A0A6G4R5M9|diphthine synthase|EC 2.1.1.98|Natronolimnobius sp. AArcel1|TrEMBL
MLTFIGLGLYDERSITVEGRDALRNADRAYAEFYTSKLIGTTLDDLEAYHGTDIEVRDRA
GVEQEPEEMLAAAETEDVAFLTAGDTMISTTHVDLRLRAHERGIETHVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTNTIDENRADGLHTVVYLDIKAAREEYMTA
STGAELLADEYPDLVGVVVARAGSPDPLVEAGTMAELADREFGDPLHLLVIPGECHLLEA
DALVELAGADRDALEIA
>A0A520KT75|diphthine synthase|EC 2.1.1.98|Candidatus Methanoliparum thermophilum|TrEMBL
MLIFVGLGLYDEMDISIKGLETIKRSKKVFVEFYTSKMMGTTIDRLEKFYGKDIELLGRE
DIEIRPDKIIETARNKDVAFLCAGDPMIATTHIDLRIRAEDAGVKTRIIHGSSIQTAVIG
LSGLQNYKFGRSTTIPRPYKNIIAESPYDVFKNNLDNNLHTLFLLDISDEPMTINEGLKI
LLNISDKRKDYKFKDNLCVGIARAGSDNPVVKADFIKDILDYNFGPPLHTFILPAKLHFM
EKEALIRFAKAPKEILTKET
>A0A842XL28|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MVRRSGKLSFIGLGLHDENGITLAGLDRIRSADVVFAEFYTSKLSEGALERLSAMTNKEI
IALGREEVEDGERILKEAGEKKVALLVAGDPMTATTHIDLRLRAHKASIDTEVIHGSSAL
TAVPGLLGLQHYKFGRTTTLPFPQEGYSPTSPYDMIVENLERGLHTLVLLDIDAENSRYM
SANEGLHLLQEMERRMVKGAAKDDSLVCVVARAGSPDCLVAAGPLSKLVAMDFGGPLHSI
VVPGRLHFMEEESLGQWTNGKDR
>M0A7N4|diphthine synthase|EC 2.1.1.98|Natrialba hulunbeirensis JCM 10989|TrEMBL
MLTFIGLGLYDDRSITVEGQEALRTADRVYAEFYTSKLIGATVEELESAHDIEIEVRDRA
GVEQHPEEMLDAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIDTHVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDENRADGLHTVVYLDIKVGHERADED
EYMTADVGAELLAEAYPDLVGVVVARAGSPEPLVEAGTMTELADREFGEPLHLLVVPGEC
HLLEADALVELADADRDTLDIV
>A0A7J3U682|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MTGVTGELIFIGLGLWSEKDITIAGAEAAGECDVVFAEFYTSMLGVPKERMEDIIGGRIE
VLSREEVEDGERILGEAMDKKVCLLTGGDPMTATTHIDLRLRAIERGIATRVVHGISIVT
AASGLLGLQSYKFGRATTLAFPEGDYFPTSPYDVVSKNMEMG
>A0A075FIL3|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote AD1000_100_C06|TrEMBL
MLVFAGLGLNEKTITNEIIEEVKDADKIYFERYTSPPMPYNEYKFSFQYEQVGREFIENG
REILEQSKEGKVVLLTYGDPMIATTHMDLKMRASEAGIITKVLHNTSIITVLPGETGLHS
YKFGRITTLMAEAQIAPLSVYEVIYKNLLSELHSTILMEYNLDTMKYLDPNDAIKQLLEI
EKEQKKQVIDESTIIIIASRIGMNKQEIFCDTTSKLIKRNYDKPPYTIIIPGKLHFTEIE
SLKQLFEIQDITDNSANIKSKSTDMLEKYIPKAKITLEK
>A0A8J7XWY7|diphthine synthase|EC 2.1.1.98|Theionarchaea archaeon|TrEMBL
MLYLIGLGLNGDLTREGIAAAQRCSLYCEKYTSLLRRSLRDIEKAVQKPITLLSREDIEE
TETLLEEAMTSDVALLVVGDPLVATTHSEIIIEARKRNIVTRIIHNSSVYSAIGETGLQI
YKFGKTATIPFPQEGFAPTSFYEIIEKNRSIGAHTLVLLDIQEDQKRYMNPSEAMKVLDH
LGFTDDLLCVSRLGYEDQNIAYGNISTLLSLGEDCWGSPPHCLVIPSSLHFKEEEFLEAF
AVEVSG
>A0A0Q0WLP1|diphthine synthase|EC 2.1.1.98|Acidiplasma aeolicum|TrEMBL
MLNIIGIGLRGYKSITLEQLDAIKNSDIVYFETYTSISPENTFDYLRSITGKKLIKADRN
TVESSNEIIKNALNSNVSFIVTGDALTATTHNELRLEAIKNGIDVKIFENASIFTAFPSR
TGLFNYRFGPVISLPFIYENFFPLSVYDKIYKNYVNDFHTLILLDLKNGQTMEINEALDI
LIKMEEKRNGNIINYDTFIIAGFNIAREDEYIIAGHIKDVINKKISMSPASIILPAKLND
KEIEFVKIFCDNV
>A0A160VSA1|diphthine synthase|EC 2.1.1.98|Thermococcus chitonophagus|TrEMBL
MALYFIGLGLYDEKDITLKGLEIARKCDYVFAEFYTSLMAGTTLEKIQELIGKEIKVLSR
EDVEMNFERIVLPLAREHDVAFLTAGDPMVATTHSELRIRAKKTGVKSYVIHAPSIYSAI
AVTGLHIYKFGKSATVAYPEGNWFPTSYYDVIKENKERGLHTLLFLDIKADQRKYMTANE
AMKLLLKIEGMKRQNVFTEDTLVVVLARAGSLEPTLKAGFVRDMIREDFGKQPHVLIVPG
RLHIVEAEYLVEIAGAPKKIIERGQGL
>A0A7J4KF70|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MKKIPKGRLVFVGLGLYDETDVSVKGLEELKQCETIFAEFYTMKLGTFNKKSFENQIGKE
IKVLSREETEKGDKIIEAATQKSVAFLTGGDPMIATTHVDLRLRAIKEGIVTKIIHSSSV
ATAVPGLLGLQNYKFGRTTTLVHPEKDYFPTSPYTVICNNKKMGLHSLILLDIQAEKNQY
MTANEGFELLMKMEKKLKKRLLNNDTIACVVARAGAPDPMIVADTIQNLKTMDFGPPLHT
IVIPGNLHFMEIEALELCANLPVGLKTKIQKL
>A0A7C7ZCE7|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MSPKNSCEDGHASPCRSTVSSPINTLRYSHQSLSALSSGLPSCSTTSNFARPSGRDRGAP
KSSGISLESPSSAGNTCMAGASRSCSRIRPKACSTWRLGTEIWRITFMMCSGAARFTMTD
GVGGPGLWLIGIGPGDLDHMTERARSVARECSKRFLEGYTAVLPPSEEERLESVVGSWEK
LMRNGVEKPNKLLKLASKRPVALLIVGDPMQATTHIDLEERCAEEGINFHVIPGLTATAL
AVSLSGLQSYRFGRQVTIPFSAGDYLPTSPLEMICKNKESGLHTLVLLDLDPTGMGLETP
RPMVPGEAVALLERMGERTESISSSLDQPIRNWVGMLLSDLGTEEEQVVSGTLGELSEIG
IGYVHAFILPAEFSGMEESAFERRRLPN
>A0A367I750|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MISFGFPSEKTISNSQRGFGKFILADTEIGIRRLFPSSEEKILCSLDNQSYFVISVKAAC
TFLFGTSKCRITFMMCRRLDPFTMTEERLSAGLWLIGLGPGNLDHMSKKAIDVARACSER
FLEGYTAILPPYQEDRLEDFVGKWERIMRPLVEDPEKLLKLAKEEPVALLIVGDPMQATT
HVDLEARCDELDIDFNIIPGITATALAVSLSGLQSYRFGRQVTIPYSYGDYLPSSPLEMI
YRNYDNNLHTLVLLDLDPTGMGVEKPTPMSPHDAFTILQKMEKKMVEGGKKISQPVKNLD
GVLLTDISLDSQKIIAGNLSEISEYNDGWIHCLIIPSKMNQNEIDAFERRKIV
>A0A256JVD3|diphthine synthase|EC 2.1.1.98|Halorubrum ezzemoulense|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A7J4Q8J4|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLTLIGLGLNDEKDISIKGLEIVKNADIVYLENYTSSLQCSKQALDKFYGKEIQLLEREV
LEDATAILSQAAYNNIVLLIVGDVFSATTHISLFQEAKQKGIEVKVVHNASVLNAIGITG
LELYKFGKTTSIPFHKSETPYKVIKENFPLHTLCLLDLVPSENKFMEALEGIEKLKKAGF
DTNTKVVVCAQLGSDNPTILYTEAKNVKLLNKFPQCLIIPGELHFMEKEMLESYKPKISV
>A0A8A3S7V2|diphthine synthase|EC 2.1.1.98|Methanofollis aquaemaris|TrEMBL
MLTFIGLGLFDENDVSVKGLEQIRRADYVFLECYTSVLTGTTIERMEEFFGKEVKTLGRD
DVEGHPEDFLRLAQDSDVAFLTAGDPMVSTTHIDLRIRAADMGIRTAVVHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGKWAPKTPVEVIEHNMAENLHTLVYLDIQPERYMRVPEAVG
FLEEMAAERGLSIPVYVGVARAGSAEPMVAAGTAGDLAKVDFGDPLHILVVPAELHHMER
EYLETFAGL
>A0A849PK73|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGVKAIKDADMVFAEFYTSKMMGTTIERMESRYQTTITTLSRD
EIESDPAWLHHATDRDVVLLSGGDPMVSTTHIDLRLRASDLGIATAVVHGTSIASAAAGL
AGLQNYRFGKSATIPFPYTARSKTIVSETPYNTVLLNRDNDLHTMLFLDIDPLKGFMTIS
EAAQLLMQVDERGLLDRALGIGIARAGSPDVMVKCDYLRDLAGSDFGAPMHLLIVPAGLH
QMEAEALVRFAGAPDELIER
>A0A1V4Z564|diphthine synthase|EC 2.1.1.98|Methanocella sp. PtaU1.Bin125|TrEMBL
MLTFIGLGLYDEKDISLKGLEAIRDADVVYAEFYTSRLMGSSVEKMDALYGKKVNVLVRE
DVEQHPKENVLRDARDKKVVFLTGGDAMVATTHVDLRLRAKQMGIETRIINGPSIQSAVC
GLTGLQSYRFGKAATIAFPYKGNISETPYDTVKMNKKNGLHTLLFLDIDREKGFMTINEG
IDLLLAVEARRRENVVTGTICVGVARAGSPDPCIRAGKIEALKSFDFGRPLHIMVVPADL
HFLEEEALQAFAGL
>A0A7J3XFZ3|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MAGELYLVGLGLSPEYVSVKALEVLRTADFVYVDTYTSYVDLELLRRVVGRDLTPIRRAD
LEERSGALILEMLKRGYRVALAVPGDPLVATTHVTLLLEAHRRGVPFHVVPGVSIVPTAL
TLSGLMVYKIGKVATVVYPKDGVLFEYPYDVIKLNDSGNLHTVLLLEYDGERGVAMTVRE
AIEILLTIEERRGEGVLTGERLVVALAGLGYPGYSVCAGRLKSISNLRVDKVPQTLVVVS
PKPHPVELEAMEAISSRWCRVG
>A0A7J4GLZ9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTVENGLWLIGLGPGDLDWMTVAARDAARTSDHRFLEGYTALLPPVELERMESFLGPWSR
RMRSAVEDPMEILALASHSKVALLIVGDPLQATTHVDLQLRCEEQGVACHVLHGVSITTI
VTGAAGLQSYRFGRQSTFAYPYGDYLPTSPLKIILANRERDLHTLALLDLDPTGMGEGEQ
QPMTPAVTIDVLRRMAAELEVDVEDWNLLLCSDMGTADARIILGTASDIARVEGGRIHCL
LIPAKLHDVEREALERW
>A0A6V8DX11|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MENGNETGFSLIGIGPGKVESMTIEAIEAAKNSGVRLYEAYTALWPESELEKLEAMVGPI
ERIMRPAVERPEELFQRAQTTSIAILVVGDPMQATTHIDFQLRAEKQGLPCRVIHGISVT
TLVPGSTGLSDYKFGRSTTLTYPYGDWVVTSPLEVMLRNQMQGLHTLVLFDLDPTGAGTG
DQRPMQPSDALASIEKMATKLRDSVVDDAIKEQARSVFDSMCVLCSDLGTDDALMKTTTI
RHLGEVPGGRLNCMVFLANTSEMEQEAINRWK
>A0A0A7GF56|diphthine synthase|EC 2.1.1.98|Geoglobus acetivorans|TrEMBL
MPLTFVGLGLCDERDITLKGLEAVRNADRVYVEFYTSRLSTSLETLERTFGREIELLERR
HLEEESAKLIDEARERVVVVLVPGDPMIATTHSSVVFEAKKKGVEVRIIHNASIVSAIAG
VTGLHIYRFGKIATVSYPYRNTVSRTPLDVIKQNLSINAHTLLLLDLNPEPMTIEYAVEL
LERIDDGTLDHFAVGVARVGSDDSLAVCDKFYRLRDHDFGKPLHSIVVLARTIHITEYEF
LREFANAPASLESLVE
>A0A897NWY0|diphthine synthase|EC 2.1.1.98|Halapricum desulfuricans|TrEMBL
MLTFVGLGLYDERSITLQGRDALEQADQVFAERYTSRLVGADFDDIEAAHDIDIDLRARE
GVEQDPEPILDAAESGDAAFCTAGDTMISTTHVDLRLRAHERGIETRIVHGTTAAAAASS
LTGLQNYRFGKATTLPFESAHGGDGVPGSVIETIEANRDRGLHTLVFLDIKVDSDREDYM
TGDEAAAMLATDWEETVPAVVVARAGSPDPVVRGDRLDALAEETFGEPLHMLVVPGALHH
IERDALVELADLPAEVADLA
>A0A7C0YX41|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGLYDEKDMTLRGLEAAKSCDKLYIERYTSAWHGLENLKVKLGKEIVEVRRKDL
EEEQGKILEEAKSKVVGILVPGDPLVATTHIDILIQARKMGIKTSVVHAPSIYSAVGETG
LFIYKFGKTTTIPFPEKGYEPQSPYDAIKENKERGLHTLCLLDIKERPMTPREALEYLLK
IEEKRREKVITPGDKVIVFAVRERGSVTYDTVENLMKREFPTPAVIIIPGKLHSMEEEAL
K
>W0K497|diphthine synthase|EC 2.1.1.98|Halobacterium sp. DL1|TrEMBL
MLTFVGLGLYDERSVTVEGREAIADADRAFAEFYTSRLVGADVADLEAYHDTDIEVRDRA
GVEQDPEPILDAAEAGDTVFLTAGDTMISTTHVDLRLRAEDRDIDTRVVHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADGVPGSVVDTIEANLERGIHTLCYLDIKVDHPRIEGD
EYMTASHAAALLAKHWDPDALGVVVARAGAPDARVRADTLAALAELDFGDPLHLLVLPGD
LHHVERDALVGLADAPEDRLD
>A0A497TCC1|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLISLGLWDEKDMSLRALEAGRKCKKLYLELYTSPWFGSRKELERLFGKPIELVGRQK
LEEGISGLIEEARKTDVGILVPGDALSATTHLSILAEAKRQKVKARVIHGSSILTAIAES
GLSLYRFGQTVTLPKDGPKKSFWDAVRKNLRAGLHTLVLLEPGLGLERALKLLKLRRPLV
AGCRFGGETLIRYGRPSKLKELGDCQPAVLVIPAKLSFYEEEFLSILAKE
>A0A7C3SEA0|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MQLLIQLLLEARKKGIKTKVIHNSSIISAIAETGLHLYKFGPCVTIPFPEKTKGKLPESV
YEIIKMNKSRGLHTLCLLDIDAEENKLMSVKEAIEILLRLEEERRENVINEKEKIVVFSK
AGSENAKIFFDALKNFKEKEVGLPAVIIILGLLHFTEKEFLETISSFLPY
>A0A836BEM6|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFVGLGVSGIDSISVATQKLLKDSNLVYLEQFTSPISTAEISKIKKLAKSKLKIAKRW
LVEDGNEILDNAKKKKVVLLSYGDPYIATTHIELRTRAIKNKIKTQTVHAASSLTSLVGE
SGLHYYKVGRIVTIVRELKTMATPYYIIYKNLIDGNHTLLLLEYDQDSKFFLKPNNALNA
LLDTEKEQKRNVITPSTFAIVASRIGLKIQSIIAGKISKLIKSDFGKPPHTIIIPGKLHF
TEADAIKILAKCLDQPFDNSDKIKNIPKQMLEKYVPMVRLALKEIGPYYKDSKEFQEVLE
NAELYIRDAEKFLEQGKEEVAILSIGYADGLVDSLRIAKGLEPKM
>A0A524J927|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccus sp|TrEMBL
RAHKASIDTEVIHGSSALTAVPGLLGLQHYKFGRTTTLPFPQEGYSPTSPYDMIVENLER
GLHTLVLLDIDAENSRYMSANEGLHLLQEMERRMVKGAAKDDSLVCVVARAGSPNCLVAA
GPLSKLVAMDFGGPLHSIVVPGRLHFMEEESLGQWTNGKDR
>A0A6G3ZQI8|diphthine synthase|EC 2.1.1.98|Halorussus sp. MSC15.2|TrEMBL
MLTFVGLGLYDERSITVEGRDALRNADRVFAEFYTSRLLGATVEDLESYHDADIEVRDRA
GVEQDPEDILRAGSDGDAVFLTAGDTMISTTHVDLRLRAEERGIDTRVVHAPTAESAASG
LTGLQNYRFGKATTLPFEYAHGADGVPASVTDALDENRERGLHTLVYLDIKVRNDEYMTA
DHAARLLADDYGDVLAVVVARAGSPDPLVAADRLSNLADRQFGDPLHLLVVPGDLHHIEA
DALAELADAPEELLDVE
>A0A7C5T433|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MSCVVGELYLVGLGLSPEYMSIKALEVLRTVDLIYVDTYTSYVDLDLLKRLVGRDLTPIR
RVDLEERSGAPILELLERGYRVALAVPGDPLVATTHVTLLVEAHRRGIPFHIVPGVSIIP
TALTLSGLMVYKIGKVATVVYPKDGVLFEYPYDVIKLNDSSNLHTALLLEYDGEKGVAMT
VREAIEILMTVEERRGEGVLTGERLVVALAGLGYPGCTICAGKLKNISNLSIGKVPQTLV
VVSPKPHPVELEAMEAISSRWCRVG
>A0A533MLX2|diphthine synthase|EC 2.1.1.98|ANME-2 cluster archaeon|TrEMBL
MLTFIGIGLYDKKDISIKGLEAVRAADRVYIEFYTSTLSGTSIEKLQTFYGRRINLLTRE
DIEQNPDWLNYAKTENIVMLTGGDAMVSTTHIDLRLRAIDLGIETTIIHGPSIISAVPGL
TGLQNYRFGKSASIPYPYTSKGKTIISHTPYDIITSNLHTDMHTLIFLDIDPVKGYMTIR
QACELLLTVDSLRKEIDLKGRLAVGVARAGSPDPVVKALPINKLMDFDFGAPLHILVVPA
QLHFMEAEALVKLAEA
>A0A843ENW9|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFEAIEDLVGQEIEVLVRG
EVEEEHKFIEEAKTANVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYESIEENLKMELHTLVLLDIQAHNDRYMTVNQGL
EYLMNIKNDLDREGLITEDTLAMGIARVGSKDVCVKAGKISELIDFD
>A0A075FSH9|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote AD1000_44_E12|TrEMBL
MLWFVGLGISGPKSIPIEVVKIIQEADFVYLETFTSPISQIHEEEIKNMVNGNYKIAKRW
LVEDGQEILKASKSSIVVLLSYGDPYVATTHIELRTRAKLENIETKQFILLRL
>A0A843LBY8|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon|TrEMBL
MLTFVGLGLFDLEDISVKGLECIRTADILFLEAYTSKLAGCTVKEMENRYGKEIQILSRH
DVEVDPDPLLELAATNRVVLLVGGDPMVSTTHIDLRIRARMRGISTRIIHGSSISTAVCG
LSGLQNYRFGKSCSLPFPHGSWFPMTPINVIAENIRQDLHTLVYLDIQDDRFMTIHKAVT
LLEEMAARSGGHIPLYVGIARAGSDSPVVRAGDARTLLATDFGSPLHIIAIPASLHVMER
EYLELFGGL
>A0A836SX59|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPTEALDVLAKADIVYLEQFTSPIGKSDLTKIKNAVKGEFRPAKRW
LVEDGKEILKNAKRKKVVLLSYGDPYIATTHIELRTRAIKEKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQD
>A0A7K4FFS9|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFIGLGISGFKSIPNEALEILSKADIVYLEQFTSPIGKSDLMKIKKATSGEFKLAKRW
LVEDGSEILKNAKKKKVALLAYGDPYIATTHIELRTRAIEENIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALNG
LLETEKGQIRNVISLATYVIVASRIGFKDQSIISGKISSLKKINFGKPPHTVIIPGRLHF
TETDALKLFGQCIDEPFDNTEKTKKISIQMMKKYVPMVREALEEVIPLYKGQKEFQGILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDSLRLAKGLDPKM
>A0A832TF85|diphthine synthase|EC 2.1.1.98|Sulfurisphaera tokodaii|TrEMBL
MPTLKLIGLGLSAKFVTREAIDEISKCNVVLFESYTSLSCDINLDFIKFLNKNVIIVDRK
FIENNIKEIIKLLKEKEDVCIVTIGDPMIATTHVSLIVEVKDKGYNFKVIPGISVHCYII
SKSMLSSYKFGKSVTITYPYNNKIDTTPYDVIYDNFIRGLHTILYLDLKEDKIMTAKEAV
ELLIEMEKIKKQGLVSDDRIIIVGQRLGCDDEEVVALRLKEVFNYKFKEPPHIIVFPTDK
LHFMEVEALKCLMK
>A0A6B9FBR8|diphthine synthase|EC 2.1.1.98|Haloplanus rallus|TrEMBL
MLTFVGLGLYDERSITVEGRDALRAADRAFAEFYTSRLVGTSVDALESHHGVDIEVRDRA
GVERNPDPILDAAADGDAVFLTAGDAMISTTHVDLRLRAIDRGIDTRVVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPRAHGGAGVPDSVVDSVAANRERGLHTLVYLDIKVDDGRGPDA
GERFMTADVAADLLAAEWPDRLAVAVARAGSPDPLVAADRLAALADRDFGDPLHLLVIPG
EVHHVEADALRTLADAPAALLPE
>A0A2I0NHC7|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon HGW-Methanoperedenaceae-1|TrEMBL
MLTFVGLGLYDEKDITVKGLEAVRSADEVYAEFYTSHLIGTNIGKIEELYGRKLTVLKRE
EVEQEPVWLKSAKDKNIVFLTGGDAMVATTHIDLRLRAKEMGIETAIIHAPSITSAISGL
SGLQNYRFGKSATIPFPYTRNDKKIISEAPYDTIKMNRKNDLHTLIFLDIDVEKGFMDIK
TAVSLLLEIEGHRGEGVLEKSLAVGIARAGSGSPGVHADYLENLKSYDFGGPLHSLIIPA
SLHFIEAEALVKLCGAPPEILK
>A0A2V2N8I7|diphthine synthase|EC 2.1.1.98|Methanospirillum stamsii|TrEMBL
MLTFIGLGLYDLDDISLKGQNAIIEADAVFLESYTSILTGTSPAELEKRYGKPIKILKRQ
DVEQHPEPILDAAKTGKVAFLTGGDPMVSTTHADLRIRAKNLGIETRIIHGSSIVSAVCG
LSGLQNYRFGKSCSIPYPAKNWFPRTPLDTILSNLIQNLHTLVYLDIQETAFMSVQEGIG
ILEQLITGDSEKISLYVGIARAGSENPVVAAGTSEKLKDVNFGPPLHILIVPATLHDIEQ
EYLTLFAGYAPA
>A0A1J4LUL4|diphthine synthase|EC 2.1.1.98|Natrialba sp. SSL1|TrEMBL
MLTFIGLGLYDDRSITVEGREALRSADRVYAEFYTSKLIGATVEELESAHDIEIEVRDRA
GVEQHPEEMLDAAENEDVAFLTAGDTMISTTHVDLRLRAHERGIDTHVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDENRADGLHTVVYLDIKVGHERTDED
EYMTADVGADLLAEEYPDLVGVVVARAGSPEPLVEAGTMSELADREFGEPLHLLVVPGDC
HLLEADALCELADADRDTLDIV
>A0A7D6GSC7|diphthine synthase|EC 2.1.1.98|Natrinema sp. YPL30|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSQLIGTTIDDLESYHDLEIEVRDRA
GVEQDPGDMLAAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKAERGEYMTA
DVGADLLAEEYPDLVGVVVARAGSPVPLVAAGTMAELADREFGEPLHLLVIPGECHLLEA
DALVELAGADRDTLDIA
>A0A2R6KSS3|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_6_65_46|TrEMBL
MLTFVGLGLWDEESITVEGRRALRAADDVFAEFYTSRLMGTDPESLAAHHGVEIDVRDRA
GTEQEPGAVLDAASDGDAVFLTAGDTMISTTHVDLRLRAHDRGIETRVVHGTTAAAAAAS
LTGLQNYRFGKATTLPFPYAHGGDEVPASVCETLDANRERGLHTLVYLDIKRERGEYMTG
DVAASLLAEGYEDVLGVVVCRAGSPEPRVEAGRLSDLAGREFGGPLQLLVIPGELHYIES
DALRALADAPESLTEPV
>A0A1V4ULV4|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon PtaB.Bin152|TrEMBL
MLTFIGLGLYDHKDVSVRGLECIRSADVVFLEGYTSRLAGTSIAEMEAWYGRSIRVLGRE
EVEQHPEIVLDPAVTGDVAFLTGGDPMVSTTHSDLRIRAQLRGIKTTLIHGASISSAVCG
VTGLQNYRFGKSCSLPFPQKNWTPMTPIDVIRMNLSQGLHTLVYLDIQDDRCMTVPQAVF
LLEEMAQKAGISIPLYVGVARAGSPDPVVLAGPAERVRNADFGPPLHILVIPGPLHVMEE
EYLSLFGGL
>A0A0G3C7Q2|diphthine synthase|EC 2.1.1.98|Methanosarcina barkeri CM1|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADVVYAEFYTSYLMGTNLEKMEKLYGKKVFLLSRE
DVEQHPDWLSEAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGSSIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRGEGIMRGAVAVGIARAGSEKPVVKADYAEKLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAEAPAGFMNEAE
>A0A2K2VE69|diphthine synthase|EC 2.1.1.98|Fervidicoccus sp|TrEMBL
ILARAGELLDEDLNPPHSLIVPGNLHFVEKDSIEVFRI
>E1QP35|diphthine synthase|EC 2.1.1.98|Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)|TrEMBL
MGQEAPTLYIVGLGLSPANITAEALEVIRSVDVVFLEMYTSKGPAEFMDQLRSIRGDLIQ
VSRRDLEDMNSEIIMRVLEGGRNAALLVIGDPMIATTHAVIAVIAKRRGFNVRVINSVSI
VCAVLSQLGLSPYKLGPVATITYPRMGVLSMRAYEVLSDNLIRGLHTILLLDIKDDGSFM
SASEAVELLKKMEDNGKLGIISKDLAVVYAARIGWGNQSIKVSTIEDVPNIGETPHTIVI
PGLLNPVEQEYLVNVLGADEELIRRHMAFINKMVKRGPLV
>A0A843KLM4|diphthine synthase|EC 2.1.1.98|Methanolinea sp|TrEMBL
MLYFIGLGLYDHKDVSVRGLECIRGSDCVFLEGYTSHLAGTSHEEMESFFNTPISVLERE
DVEQNPDLILDAAEKGIVAFLTGGDPMVSTTHADLRIRAKERGIKTAIVHGASISSAVCG
LTGLQNYRFGKSCSLPFPAKNWSPTTPIEVIGKNLDAGLHTLVYLDIQKDRYMTVPFAIG
LLEQMAEKAGMKIPLYVGVARAGSSDPVVSAGPAQKVRNTEFGPPLHILVIPGPLHVMEE
EYLSLFGGL
>A0A831PL06|diphthine synthase|EC 2.1.1.98|Pyrobaculum sp|TrEMBL
MLTIVGLGPGPGYATEAALRAIREADCVFYEDYTGPLDLETLRRAAAKEPVRLTRRDLED
ESGQAVFDCLREGKKAVLVTAGDPALATSHHALVALAAARGYKVRVIPGVSIICAAFSVS
CLSIYKLGGVATVTYPRGGIYSLRPYELTEHNLQRGMHTLLLLDVKEDGTFMPLRDAAEV
LLTLEDRERRGVFTPDRQAVAVQRLGWGGSLLYTTLGRLREIEAEGPAVLIIPAKLSPVE
RECLEAVAGT
>A0A2R6FUM1|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_6_68_27|TrEMBL
MLIFVGLGLYDERSITVAGREAVRSADRVVAEFYTSELAGVSLADLERFHGVDIEVRDRD
GVEGSPDDFLADAESGDVVFLTAGDTMVSTTHVDLRLRAHERGIETRVVHGTTARTAASS
LTGLQNYRFGKATTLPFERSHGGDGVPASVLETIAANRERGLHTLVFLDIDAAGDAYMRA
DAAAGMLATTLDESDDETVVDATSGGNTLGVAVARAGSPSSVVRADALSTLAGESFGNPL
HLLVIPGELHHVERDALAELGGAPERVLPDLR
>A0A842XZR4|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon|TrEMBL
MLTFVGLGLYDEKDITVKGLEAVRSADEVYAEFYTSHLIGTNIEKIEEFYGRKLIVLKRE
DVENDPLWLSKAKDKNIVFLTGGDAMVATTHIDLRLRAREMGIETKIIHAPSITSAISGL
SGLQNYRFGKSATIPFPYMRNDTAIISEAPYDTIKMNRQHDLHTLIFLDIDVEKGFMDIK
TAVSLLLEMEERRGEGVLEKSLAVGIARAGSETPCVHAGYLENLQSYDFGEPLHCLIIPA
SLHFIEAEALVKLCGAPPEILK
>A0A7C0XRQ1|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYFIGLGLYDEKDLSLRGLEIIKKCSEVYAELYTSFFHGDLKKLEELSGKKIRILGRED
LEEKSSKLIEKAKKENIALLVPGDPMIATTHAAILIDAMKKGIKTKVVHSSSIYSGIGET
GLHIYKFGRTVSLPYPQDNYMPESPYLYIKENLDLGLHTLVLLDVKAEQKKFMSINEALR
ILLEIEERKRLGVITAEKEVLGISRLGS
>A0A7C4NUY3|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MVLVFVGLGLEKGGISLRGIEEAKKADAVYLETYTSIVPGLSVSYLQELTGKKVKVLDRR
LLEEEPHEILEKARDGRVVLLIPGDPMVATTHIDLRLRAAKMNVETKIVHAGSILSAVAG
VCGLQSYKFGPSATIPFPDNPSARPYEILADNRKRGFHTLLFLDIRAEEGRVMSANQGME
IMLGHELVRRESIFTPNTLVVVVARAGCEDELVRAGRVEEMLGVDFGPPPHSLVVPGRLH
FIEAEALKVFARAPEDAVDELVG
>A0A7J3EEZ0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKAGELIFVGFGLGEGGLTLKGLETVRSADEVYVETYTNYTPEQVLRKLENASGRTFRRV
SREDLENLGGKFILDKATEFKVVLLTPGDPFAATTHIALRLEAEKRGIKTSVVNSSSVVA
SAAGACGLQIYKFGETATVCFPDGGAVSTKPYETTFYNLARGLHTLLLLDYRAYENKAMT
VNEGLRILREVEELKQMGIFTEDRLVVGLARLGYDDFKVKGGRLDELIHEDFGEPPHCII
VPGTLHFLEIEALVRLASVKRSHVVNIPRFRGFIELDVLDRYIVGVKNVFREMKILGESR
EMFSRELNLALEWARNYYNDSVAFKLKGDLVSSLIAIAYCEGILEGMRLLKLVDFKWEGE
R
>A0A832NRZ8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLGLYDEEGLSLKGLEEVRRADLLFAELYTSFMPGLSVSRLEVLAGKRV
>A0A419JYK5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MEGGGLDPILGELTFIGLGLFDELGISLRGLEEAKKADYVYAELYTSLMGGLSIESLQNL
IGKEVHVVDRRLMEDESGEPILEKAEESRVVLLVPGDPLIATTHIDLRLRAERRGIRTRV
VHAASILSAATGLSGLQNYRFGRNVTIPFPEPGFVYETPYEVIRENRGRDLHTLCFLDIR
VEEGRFMTVKEGLQALLKVEEEKKLGVVTPRSLAVGVARAGSDNAVVKADYVERLMEYNF
GPPPHTLIIPAGRLHFVEAEALITLAGAPAEIREMVT
>A0A7C5XC32|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
AYTSFMPGFSLKNFERLVGKQVVVVSRRQLEDENGRVVLEAAGRGKVVLLVPGDPLVATT
HVAVRLEAQKHGIKTRIVHGASIVSAVMGLCGLHNYKFGKSVTIPFPENFSETPYNVLAQ
NMRLGLHTLCLLDIDVEKNRFLTVREALEMLLRVEAERRLDVLSEETLAVGVARAGSPNP
TVKAGFVKELLSYDFGGPPYSLVFPGKLHFMEAEALVAFAHAPPSIRRLVE
>A0A537G807|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MPKVTFIGLGLDSERGITLEGLDAARNASSVFAEFYTNLMPNLDVANLERLVGRKVAVLN
RQDIEDSHGKDVLLAAKEGDVTVLVPGDPMVATTHVALRLSLAKRGIESRIIHSASIISA
VCGATGLQNYKFGRSVTLPAEPPVPKSVIHTLVENRLRAMHTLLFLDVRVEEKAQLTIPE
ALEKLRKAMPESSDWLAVGLARVGARDQLVKAARLDRLSKQSFGGPPQVMVFPSKLHFME
AEALKVFCGAEDADLEGTA
>A0A7J3M9U3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGGKLYIVGAGLSSDLITLRGIKTLKNSDIIFMDSYTSMLCNSDLEDIIGRRIYKLRRVD
LEERFEEVLFKPVLQGLNVSLIVPGNPLDATTHVSLIVEAYRRNIMFEIIPAPGIIPNAL
SMSGLMVYKIGKVTTLTYPKQGFISDYPYDVIKDNDLRNLHTILLLEVDLENNIVMSISD
AVDILLKLEEKRGEKIVNEERKAVAISGLGGSNQRICFNSLKKLKTLPKHRGPHTLVLTS
PKLHFMEEEGLKALSTFNINAN
>A0A537GMI9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDSVAFLVPGDPMIATTHISLRLSLSKTGIGSRIIHGPSIISA
VCGATGLQSYKFSKTVTIPYDPPLPASVLETISDNHGRGLHTLLLLDVKADQNKQLTIAE
ALTKITSANPSLESRLAVGVARIGARDERVKASRIGLLINEDFGGPPQSIVVVGKLHFME
TEALRIICDAQDSDLRENS
>A0A7C0Z793|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGRGLKLISIGLADEYDLSLRAIEEARSCDKLYVELYTTRLSTSRERLEEVLQRPLTELS
RMDLEGERPRILDEASRSLVGLLIGGDCLAATTHISLLLEAKRQGIPTWVIHGSSIFTAI
AETGLSLYKFGRIVTLPLPERGPPDTVLEALEGNLSLGLHTLILLDLDVERGRWLSVSEG
VRLLLEADRPEVFNEETPAIGVARLGWSNPLIKGGRAVDLLDVDFGDPPQALIIPGRLHF
MEEEGLRLLADCPGEALKGWRPRGELEHLVERYMESCRRVMEKLRDKPLSEETKRLLDYA
ARYLSDAEYYAGEGRWPTALAAISYCEGLLDALRLLGLAEFEW
>A0A497JZG2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLSWGHEGLGELIFVGLGLFDENDVSLRGVEEAKNADVIFAEFYTGLLAGLSLRRLEKIV
GKRIIVLRRRDLEDECGESILRAAENGRAVLLVPGDPLIATTHIDLRIRAEKRGIKTRIV
HSASIVSAAMGLSGLQNYRFGKSVTIPFPVNGRVSRTPYDVIAENKRRDLHTLCFLDLDV
EGGRYMRIREALKILLSLEDDIGGGILGLESLAVGISRAGAKDGIVKAGSIRELLGFNFG
DPPHTLIIPSENLHFMEAEALSVLADAPKWVREMIK
>A0A7J4L0P2|diphthine synthase|EC 2.1.1.98|Methanocellales archaeon|TrEMBL
MLTFIGLGLYDEKDITLKGLEAIRDADLVFAEFYTSALTGTTIGAMEHLYGKKIVVVDRE
DVEQADQILACAKDQNVVFLSSGDSMIATTHVDLRLRATDKGIGTRIIHGPSIYSAVCGL
TGLQNYRFGKSATVAFPYKKQISEAPYDTIKVNKEHNLHTLLFMDIKEKYMTINQAIGLL
LSVERMRKEEVISGIAVGISRAGSEDPVVKADYVDRLQKYDFGPSLQSMVFPGKLHFLEA
EALIKLAGAPSEITGEVP
>A0A3R7F301|diphthine synthase|EC 2.1.1.98|Candidatus Syntrophoarchaeum sp. WYZ-LMO15|TrEMBL
MLTFVGLGLYDERDITLKGLEAIRSAEFVYLEEYTSRLGGCNREKLEGVFGRKVLPATRT
DIENDPEEILRRAASSDVVLLTGGDPMSATTHIDLRLRAHDRGIKTRIIHAPSIFTAVAG
ITGLSSYKFGKSATISYPWGERGVISEVPYDTIKINRAHGLHTLLLLDISNGRCMRIHEA
LKILSMLEEKRDEGVVDNLLFVGVARAGSEDMTVKAGDLETLMHFDFGPPLHVLVAVGEL
HFIEHEALVKFAGLKGDL
>A0A832XF83|diphthine synthase|EC 2.1.1.98|Candidatus Naiadarchaeales archaeon SRR2090153.bin1042|TrEMBL
MIKLIGLGLWNEKSMSLEALEEAKDCDVLYVEFYTSRLTGLKNISELENQIGKEIKVLNR
EQFEGKTKNFLQEAREKNIGILVAGDALTATTHIDLLIEAKKGGIEFRVVHGSSIYTAAA
GLSGLQIYKFGRATSIPFFKAESPYDILAENKKAGLHTLIFLDIQNENLMSANEAMKKLI
EIEKKKKKKVFTENTEIVIVARAGSENPLVKFGKVKELLKEDFGGPMHVLIVPGKLHFKE
REALELNKF
>A0A7J2Y9G2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGLGLHDEKGITLRGLEEARSSEAIFAEFYTSRLVGARLSAIEDLLGKKVRVLAREEVES
GKAILEAASRSRVAFLVVGDPMAATTHVDLRLRARAAGIRTRVVAGVSILTTAAGALGLQ
AYKFGRTTTIPFPAPGFRPVSPLEAILANRRAGLHTLILLDLREDGTFHGPKEALRQLLD
AAEAKGAPEFGPEALVAVLSRVGSPEERLVAGRVRELLHQDLGPPPHCFVALGALHFLER
EALEAFAGLPQGV
>A0A7K4ALZ1|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MMGHLIFVGLGLSRPEDMSMKALVALRGCDEVFAEFYTSRLIDACQAELEEFIGRKITVL
NRKEVEEGTIILKAARQHKVAFMVAGDPMSATTHVDLRLRAAEEGITTELVHGVSIFTAA
AAAFGLQPYKFGRAVTIPFPEPGYLPASPYDYILENYSRGLHTLVLLDIREEEDRYMTAN
EAVRWLLDAEQRLGKGLLNDETIICAGARIGSTGQRLLAGDPQTILGADMGPPLHCLVIP
GRLHFMEAHALVSFASAPRDILEED
>A0A534J0H4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MRSSFLRSPASCSSRRTSSPFVRGTSTQRDRIVCSIRSTLFLGFHRPRTYLWRPLLGSPA
LGDLVFIGLGLFDEKDITLKGLEIARAADAVFAEFYTSSLRGTTVETLRLMIGKPIRVLS
RKDLEQGSEVIEAARHGTAALLVPGDPMSATTHIELRLRADDEGIRTRIVHGPSIVSAAA
GLLGLQSYKFGRATTVPFADDKFRPASPLEVIEENRKRGLHTLVLLDLKEGGEFLTAPEA
IRYLLELAKEKKSKAFTRDTLVCVLGQAGSDTPSILAGRAGDLAARDLGRPLHTIVIPGE
LHFMEKEALIKIAGAPKDL
>A0A510N6B9|diphthine synthase|EC 2.1.1.98|Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)|TrEMBL
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHIERDALRELAGAPADAL
>A0A7C7KH75|diphthine synthase|EC 2.1.1.98|Marine Group III euryarchaeote|TrEMBL
VLTAVAGVLGLQHYNFGPVATLVLPEGNYKPTSPIDKIKTNMKNGNHTLVLLDIKADQPE
TEPIYMTASQAAEQIMEAGLSGEIKVAAAARVGREDQRLWYGKLKELAKLDLGKEPHSLV
VPSRLHFTEKDFLDNL
>A0A7K4DH84|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLYDLGDISLKGLECIRDADTVYLEAYTSRLMGTGIAEMEALFGKEIRVLGRE
DVEQDPQDIIEDAVRGRVAFLTAGDPMVSTTHADLRMRAAAAGVATSIIHSSSISSAAPG
LSGLQNYRFGKSCSIPFPAKGWFPTTPVETIGVNLDLGLHTLVYLDIQESRYMRIPEAIT
LIEEMAARVREIDPPALYVGIARAGSRYPVVAAGTGARLKEIDFGPPLHILIVPADLHPM
EREYLEVFAGL
>A0A7K4NLV0|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQKADFVYLESFTSPIYKQQEEEIKNIVSGSFKIAKRW
LVEDGQEILKASKSSTVVLLSYGDPYIATTHIELRTRAKLEKIETNTIHSASAITSMIGE
AGLQFYKVGRIITIMNEKKSVITPYTSIFKNLIQGLHSVILLEYNQDENYFLDPKDAISS
LMDVEKEQKRNVVNNDTFAIVASRIGFETQKITSGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKSSDNSSIIKSVSIQMIEKYVPMVRDTLEEIKSLYNDSKEFQVVIQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKI
>A0A7K4BZ67|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MLYLIGIGLNSKQISLEAIEAIKSSDSVFLEGYTSEYSQGTINEIEELVGKKVILLGRKG
VEEKFDSVLLSAKSNNIALLIIGNALTATTHIQLLIDSKENDVKYKVIPGISITNTIAET
GLDEYKFGRTVTICYHQENFEPETFFDQILENQKIGLHTLCLLDIKKDENPKRLMNCKEA
IEILEKISNKRNQKNNFEYLGLFAMSSLKQKIIFGKEKIISFKEIYDLFPQSLIILGKTN
AKEKEFLEKMY
>A0A558G9P0|diphthine synthase|EC 2.1.1.98|Haloferax volcanii|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A4E0QRU2|diphthine synthase|EC 2.1.1.98|Methanolobus halotolerans|TrEMBL
MLTFIGLGLFDEKDISVKGLEAVQNADMVFAEFYTSVLMGTTIERLEELYGKKVRILSRE
DVEQYPGWIDHAKEKNIVFLTGGDTMVSTTHVDLRLRAQDAGIGTELIHGASISSAVCGL
SGLQNYRFGKASTIPHPYTSSRGRTIVSETPYDTIKMNMEKDMHTLIFLDIDKKKGYMTV
NQALELLLEVEGRRAEGIMDNTIAVGIARAGSPEPSVKAGYVNKLKEHDFGGPLHIVVIP
AALHFIEAEALVKLAGAPPEIMYSTED
>M0ELP2|diphthine synthase|EC 2.1.1.98|Halorubrum coriense DSM 10284|TrEMBL
MLTFIGLGLYDERSVTVEGREAIREADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRP
GVEQDPEAILAAAESGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWRDELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALIGLAGAPESLADE
>A0A5C0XNS2|diphthine synthase|EC 2.1.1.98|Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)|TrEMBL
MPLYFIGLGLYDEKDITLKGLEIAKRCDKVYAEFYTSLMAGTTLEKIEEVIGKKIIVLNR
EDVEMNFEKIVLPEAKEKEVAFLTAGDPMVATTHAELRIRAKRMGVESYVIHAPSIYSAV
AITGLHIYKFGKSATVAYPEGNWFPTSYYDVVKENLERGLHTLLFLDIKAEKGKYMTANE
AMELLLKVEEMRGENVFTPNTLVVVLGRAGSLNPTIRAGYVKDMIKEDFGKQPHVLIVPG
KLHVVEAEYLVEIAGAPKEILEQFAPRKM
>A0A1H6I2T7|diphthine synthase|EC 2.1.1.98|Halopenitus malekzadehii|TrEMBL
MLTFIGLGLYDERSITVEGRDALRAADRAFAEFYTSRLVGADVDDLEAAHGTTIEVRDRA
GVEQDPDPILEAAAAGDAVFLTAGDTMVSTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGGDGVPDSVIETIEANRERGLHTVVYLDIKVGIGPRGPD
PDHEEYMTADHAAAMLADDWADVLGVVVARAGSPDAVVAADRLSALADRDFGDPLHLLVI
PGDLHHVEVDALAGLADAPADLLPDR
>A0A7G9Z3K6|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon ANME-1 ERB7|TrEMBL
MLTFVGLGLYDEKDITLKGLEAIRDAGVVYVEFYTSPLGGKTVEKMQEVYGKRISVLERR
DVEEKAEEGILKLAKHQKVVLLSGGDAMIATTHVDLRLRAIDTGIETRIIHAPSISSAVA
GLCGLQSYKFGKSATIAAPYGKKGIMSAVPYDTIRANKERGLHTLLYLDISMRINEALKL
LETAEEKRNLGGEPLKKSIAVGIARAGSDKPVVRADYFGALKSYDFGELPHVLVVPGELH
FLEREALIKIAQAPERI
>A0A7L4R9X4|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MALILIGTGVAFDLTLAGLEALKSCSEAYIETYTNPASKEQISALEKLCGRKITLLERGQ
VEGPLLVNRAKSSDVCILASGDPLTATTHITLVIEAKEKGIPVVVIHNSSIHSVAPARAG
LQMYRFGKTASLVNPRPNYKPTSSLDIIRENLVRNCHTLVLLDTEPKPMEAKTALEMLSE
FERVVVLSRMGYPDEKVTYGRIEELKNKNLGKPPFTVIVTAKLHPMEQEFLELLK
>V6AU94|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotenuis uzonensis|TrEMBL
MLWFIGIGITGPDSLSLRARQIISECDIVYFEQFTSPIKEQNSYEIRSIVKGEFRLGPRW
LVEDGREILDAARGKKVALLSYGDPYIATTHIELRVRAVLEGIQTDTVHASSAITSLIGE
CGLHYYKVGRTVTIMSGIRPSTAYYTIFENLKLGSHTVVLLEYNQNRGFFLSPVEAFKSL
LEEEREQVRKVVSDSLYAIVASRIGFEDQKITAGKISSLLDKDFGKAPHTIVIPGTLHFT
ESDALKALAECADMPEENTPKIEKISAQMMRKYVPMVRRALEQIAPHYSDAKEFAGVLEN
ADLYIRDAERFFEQGKDELAILSIGYADGLVDALRIAKGIEPEMNS
>A0A7C0ZT40|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGILYLIGLGLCNEKDLTLRGLEILRNKVKEVYIELYTAVPRKLNVDSLKELIGKDVKVL
GRDAVESNYLLDRAKETNVALIVPGDPLIATTHMSLILEARKRGIAYRVVHNASVLTAVP
GACGLHAYKFGRTTTLPYPYKGHIFESPYDVIKENLSRGLHTLILLDLDPQKGSSMSVRE
GIEILMKIEERRKEGVIRDDSILVGLSNIGSDDEIVKAGYPKDLMRYKFPMGMHSIVVVG
NLHFTEAEALVYLADAPKEILKNV
>A0A662I592|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLYFVGLGLYSCEDLSIRALRVLKKCSKIYVDLYTSIVPQFTLSEFANILEKSLGSEIVG
VTRRELENDIFVEKILEESSEKDVAIVVPGDPFIATTHLWIRLEAEKRKIPTAVIHSTSI
LTAAISETGLHPYKFGKCATIVYPDLEKNFIPYSVYETLVDNIGRGLHTLMLLDLRLEEK
IAMTIADAINVLELLEEKIGKGIISSETLGVALSRIGSPDSKIVAGPLYSLRKINLGPPP
HSLIIPGELHFTEEEALIVLAKASIEAVRTWKKKVRDLRNILNH
>A0A833A1E4|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDEKDMTLKTLEYTKRADKIYAEFYTAALTGTTLNKIEKVIGRKIILLSRE
DVECRSDKLIEESRNKTVMFLTAGDPMVATTHVDLVIEAKKRGIDVRIINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYYVIRDNLRMGLHTLCLLDIQSDKNRFMSANEGL
KILLEIEDRKRENVLNENTKVVVLARAGSLKPKIVYGKIKDLVNYDFGPPLHSIIIPGKL
HFMEEEALKYLCKNIS
>A0A662JDY1|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MTLFFVGMGLHDHLDLTFKGVEIARRCDKVYVELYTSLMAGLNLRKLEEILGRKVHVLSR
GDLEGAKAQEILREAMEDDVALLVPGDPFIATTHIALKIEAKKLGVEVKTVHAASIASAI
PGLTGLSFYKFGRKATVVYPEPNYRPEAAYDVVKENLLRGLHTMLLLDVKAEQGLYMTVP
EALRILLDVEEKRREGVLSPEALAVGVSRAGSLNPEVKACSIERLLSLDLGPPPHTLVIP
GDLHFMEEEALMYLCGATKDEVEVHKRRLKLLREVRAL
>A0A662HQB2|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLKISRLVLNGDHLLYFIGLGISEKGLSIEALEILRRVDTVFLELYTSIIPDFKLDWLEN
MLGRKIRVVDREDLEERGGEDILREAKVADVALLTPGDPFIATTHIVLRIEAERRNIKTR
IIHSSSIITAAFSSCGLQVYKMGRIVTITIPEPKVGYRPITPYLVLKENLERGLHTLFLL
EIRAESGEFLTIPKALELLEDMDRRVGEESIVDDNTLVVGLARVGTPNEYIAAGSLSELK
DIEFGPPPYSLIIPGVLHPIEEEALTTLFDCKLEVIEGWRERVKSVLKNT
>A0A075GEH4|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_12_B11|TrEMBL
MNEKKSIITPYTSIFKNLIQGLHSVILLEYNQDENYFLDPKYAISSLMDVEKEQKRNVVN
NDTFAIVASRIGFETQKITSGKFSNLLKVDFGEPPHSIIITGKLHFTESDAIKVLTECLD
KPSDNSSRIKSISIQMIERYVPMVREALEEIKPLYNDSKEFQVVFQNAELYVNDAENFLK
QGKDENAVLSIGYADGLVDALRMAKGIDPKM
>M0FL18|diphthine synthase|EC 2.1.1.98|Halorubrum hochstenium ATCC 700873|TrEMBL
MLTFIGLGLYDERSITVGGREALRESDRAFAEFYTSRLVGADVADLEAHHGVDIEVRDRA
GVERDPEPILDAAESEDVAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETIEANRERGLHTVVYLDIKVGTGPTGAD
PDHEEYMTADVAAGMLAEAWEDAPGVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVEE
>A0A5E4LF30|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MEKPKGSLSMVGIGTSDEKGISLAGLEELRSCDKIFAESYTNLMPEGTLKRLEALVGAPI
ALLSREQVEGERILLEAASSSHAALVVSGDPMIATTHVSLVIAAKKKGIPVRIFHAASIL
SAAIGESGLQAYKFGKIVTLAYWRENYKPMAAYDVIAENLSRGLHTLLLLDIDEKLGPMK
PGAAAKLLLEMEKTGKKGILLPSTKLVLLQGVGWPSPLRAYASIDEMQGRPGAGSPGPAV
LIVPSKLHFLEQEFLEQ
>A0A7C4S921|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MVLYLVGLGLGSIDYMSLKAAEEIKNCYTIYLDTYTGFISKDLMNWLTKEFYGKLRLATR
RDLEDNLGRILEEARETGIAILVPGDPLIATTHISLLVEAAKRKIPYKIIHGISIYSAAV
SITGLQAYKFGRTTTLARFGDPRETYRIIKENLERGLHTLVLLDTADGGLTIPGALRKLL
EAEDSLRYGIVREDTLAIGLARIGLQEELVKVAIVRELITESYPPPPHALIFPGELHF
>A0A7J2YKU2|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MGITFVGLGLGPKRYITEAALESIKAADVVFLDVYTGILPDETIDFLRTISKHLLIADRY
LLEDGIDAVLAEATRKSVVIAVQGDPLIATTHISIVLEARKRGIACKIVSGISSYSVAAS
LSGLQAYKFGRAVTLPMEEDIEYAKSVYESILENMSRGLHTLLFLDTKNGGLTIPVALSR
LRELERLLMKGVASDDRLVVALARLGYDDELIKAGRIADLATMDFPKPPHMLIFPGKLHF
LERETLVRLLGAPRECVEAYEPINYEVGRVKRYIDACERVLSKLGTSAEETKVNEVLNVA
KSYLDDSKFFLKSGDLFDSLSAISYCEGLLDALRMMGYVEFDWKS
>A0A7J3HPN6|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
GSKDYLTRAAEEALLESEKVYLDMYTGHISSELIDYLRELLKDRLIFAERTTIENNLYKI
IDEASRNKIAIATSGDPFIATTHIAILLEAVKRGICVKVIHGVSIISAAASYSGLSAYKF
GRIVTVPRAASMEIMEGIYRVIANNQEHGLHTLVLLDTADGGVTAQEAAEYLSRIEEKLG
WGLFRDDRIAVVLLHVGMRTASKKCYAIKDLKELSLPPPPHVMILPGELNFVEKESLKMI
AYCDYKMIDNHHPISTSRQRAKKYIDKTQGVLGKIRKEPVDLEAQEVVELASTYVYDSQS
FLLSGRTEDSLIAISYAEGLLDCLRMLGKVSFKW
>A0A8K0UZC3|diphthine synthase|EC 2.1.1.98|Candidatus Parvarchaeota archaeon|TrEMBL
MIYLIGTGLYYLSDLPIRALDPLRSCDEVFLERYTNLNDISFLHELEEKIDKKVTIKDRQ
FFESEEPIKIGKTKDIALLIPGDPLAATTHISLLSEAKKEGIRYKIIHASSIFSAIGATG
LSLYKFGAVTSIPLDSKKLHITSFMNVIKKNKLNGLHSLVLLEAKSKDTFVSEREAVELL
EELGNDFIEKDKIIILSKVGSEEEIISLFTRLEKTLEPPISLIIPGEISIIEEENMGVLL
Q
>A0A223ZI48|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp. EMTCatA1|TrEMBL
MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRSVKVLGRG
EIEEERIPLERASELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGL
AGLQAYKFGRIITIPFTADNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTASEGL
MYLLKASEKLDDDTISGETLAVVIARAGSEKPLVRADRIDALVDEDFGDPLHCLVVPAGL
HFIEAEYLVEIAGAPRAVVERMII
>A0A151BCU4|diphthine synthase|EC 2.1.1.98|Bathyarchaeota archaeon (strain B24)|TrEMBL
MYSLPLVGEGELIFVGFGLGDLGLTVKGLEMVKNADRVYVETYTNYTPDWVVERLEELSG
RRFERVSRKELEELGGAALLETASDSRVVFLVPGDPFMATTHIALRIEAEKKGIKTRVVN
SSSIVAAAAGACGLQIYKFGESATVVFPDGGTVSMKPYDTVLKNLERGLHTLLLLDYRAE
EDRAMTVNYALRLLRSLEKIRGMGVFSDDRLVVGLARLGYENCKVKGGPLKDILNEDFGE
PPHCIVIPGSLHFVEVEALKILADVEETPSKRGVGARSYIPLDRLNRYISGVEKVFRDIR
LLESSRLVDRRDVDKALDWARSYYEDSRAFRDRGDLVSSLVAVAYCEGILEGLRLLNLVE
FKWEGEV
>A0A842QPD1|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALFMIGLGLADEKDISLRGLEALKKCEFIYFENYTSKLQCNAIDLEKLTGKEHNIADRE
FVEKGSDEMIEKAKGKNVAFMVIGDPMCATTHIDLYLRAKDRGVKVEMIHNASIISAIGE
IGLEVYKYGKITSIPFHNKDVRAPVEVYEMNSKNGLHTLFLLDLDPKSKKFMSINEGAEY
LIRNGISKDAAAVGCACIGSSDRVIRAAALGELGRHDLGSPPYCIVMPGKMHFIEEEALK
LWKE
>A0A842PN24|diphthine synthase|EC 2.1.1.98|Haloferax sp. AS1|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7T5R6T5|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLHFISLGLSDEKDISLKGLETIKKCDKVYLENYTSLLNCSKEDLEKVYGKAVILAERE
LVESKADTILNEAAKKEVAFLVIGNAFTATTHTDLMLRARERGIEINFIHNASILNAVGV
TGLSLYKFGKITSIPFDYDNIETPYDIIKDNRKIEAHTLVLLDLDPSKNKYLKISEAIRY
LLKVELKRGEKVFTENTLCIGCSRIGNSQQVIKAGNAKDLLNLDFKKPPYCLIIPSKLHF
MEEEALGRYK
>A0A2D6NDL9|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLHLIGIGLNDEKDISVKGLNIVKKADFVFLENYTSRLQVSVEKLEEFYEKKIILADRE
TVERKTDLILEKSLNKETAFLVVGDVFSATTHTDLFLRAKKKKISINIVNNASILTAVGI
TGLELYKFGKTTSIPYPEKNYKPETAYDVIKNNKELGLHTLILLDIKPNKNMTVNESIRI
LLDIEKKRKENIFTEKTMVLGCARLGGDYKIKCGTISKLEKEDFGKPMHCLIIPGKLHFI
EEEALDIWK
>A0A842SF45|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLFMIGIGLNNERDISLKGLDAINKSSYVFLENYTSKMNCRVEKLEKLYGKKINPADRD
LVEKNSDEILNKALDKNVSFLVAGDVFSATTHVDLFLRAREKGINIRIIHNSSILTAVGI
VGLELYKFGKTASLPFFEKSFIPETPYTVIFENKKRGLHTLVLLDIKKDKERFMSVNKGL
IQLLELEKKLGKKIILSDSKIIGCARLGSERKVIKYGKVKDLLEFDFGKPLHCIIVPGKL
HFMEEKMLEIWK
>A0A662F6A7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTFHIIGLGLNDERDITLRGLDIIKKCKQIYLESYTSKLNCSKQTLEKLYKKRIRLADRI
LVEQNPEVMLQRAKKEDIALLIVGDPLSATTHIDLILRARELKVEVNVVFNASILTAVGI
TGLQLYKFGKTTSIVFPQQSYFPESAYDTIKMNLKNKLHTLCLLDIHAEKKRYMTIGEAI
DILLRIENKRKENVFTRNTLVVGCSCLGANNQVIAGKASEILKKRFKQGMQCLIVPGELH
FMEKEFLGI
>A0A0E3NFC0|diphthine synthase|EC 2.1.1.98|Methanosarcina thermophila CHTI-55|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTSLERMEKLYGKKVFLLSRE
DVEQHPDWLSEARNKKLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGRSASIPHPYESGRGTRVISETPYDIIKQNLELGLHTLVFLDIDQEKGYMTV
NTALELLLEVEEKRGEGVISGAAAVGIARAGSEKPVVKADYVENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAGAPIGFMKEAE
>A0A7J9Q5T8|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
TSILSCSVKKLEEFYGKKIILASRELVEKKAEETILKYALEKDVAFLVVGDPMSATTHID
LRLRAEKAGIECVVIHNASVFSAVGVTGLQLYKFGRTTSIPFQEENWHPETPYNAIKENM
KNGLHTLLLLDLRPYEKRFMSINQAIEYLLSIEEKRKEKVFSKGLFCVGCARLGSLKPCI
KAGNAEELLKEDFGKPMHCLIVPGKLHFAEEEALELFKVHK
>A0A832EP70|diphthine synthase|EC 2.1.1.98|Archaeoglobus sp|TrEMBL
MLTLVGLGLQDFRDITLRGYEAVKKAEEVYLDTYTSRISSSIEDLQRFFGKKIIEAKRSD
LEEGGRKIIERARERDVVILIPGDPTIATTHIALVLEARKANVETRIINNASIINAVCSL
TGLQNYRFGKSATISWFRSRAFIDTIYANLSIDAHTLLFLDLNPPMTIKEAVSRILELDS
GFKDHFAVGVARAGSEDAVVKCDRLKELAYFSFGEPLHSLVILSKKLHVLEYECLVYFAS
APEELREWVL
>A0A7C2FEY5|diphthine synthase|EC 2.1.1.98|Thermosphaera aggregans|TrEMBL
MLVFLGIGYSLKHLTLEAIEYLSKADKVVIDKYTSLYEDDPAGLSEYTKGELVYASRKDL
EGEGMNNLIKEARSKNIVLAVPGDPFIATTHDSLRVEAIRKGVEVKVVNSLSVLTLIQSR
LGLQAYRFGKTVTLVYPDYFKPYSTIETIYENLNRRLHTIVLLDLRLEHGKAMTIHEAVE
ILLKLDDELENRLDDSLAIGVARLSWRDERIQADLLPRLRKYDFPPPPHSLVIVSNPLPV
EIEGLKLICKLPD
>A0A3R7D001|diphthine synthase|EC 2.1.1.98|Candidatus Parcubacteria bacterium|TrEMBL
MLWFIGLGITGPDSLSENTKKVISDSDVVYFEQFTSPMPDSDVQKIKQLTKGEFKFAPRW
LVEDGKEILENAKSKNISLLSFGDPYIATTHIELRTRAIQEKIKTGTVHASSALTSLVGE
CGLHYYKVGKTVTIMSGIPSTTAYYTIFENLKLGNHTVVLLEYNQNKNFFLDPKEALQSL
LATEKEQTRKVISDSMYVIVASRIGQETQKIISGKIASLLGVDFGAPPHSVVIPGALHFT
ESDALKVLAEYLDEPADNSEKIEKISAQMMKKYVPMIRLALEQITPHYKDQKEFQGVLEN
AELYIRDAERFFEQGKDELAILSIGYADGLVDALRIAKGIEPEIS
>A0A2R6KGZ5|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_9_68_17|TrEMBL
MLTFIGLGLYDERSITVEGRDALRAADRAFAEFYTSTLVGTTVEALEAYHDTPIEVRERA
GVEQDPEDVLAAAEDDDVAFLTAGDTMISTTHVDLRLRARDRGVETRVVHGTTAQAAASA
LTGLQNYRFGEATTLPFAYAHGADGLPASVTETIDENRERGLHTLVYLDIKVDNEAAVAR
AGDEELEEYMTADTAAGYLAETYPDALGVVVARAGSPDPTVAADRLEALADGAFGGPLHL
LVVPGDLHHVERDALADLADAPAELLD
>A0A5A7RX44|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MNKGSLVFIGLGLYDEKDITLKGFEEVKKADKVFAEFYTAKLFGTTLKDIETLIGKKITV
LSREKTEKGEVVLDSAEKHYTVFLTAGDPMTATTHVDLRIRAIKRGINTQVVHGCSIVTA
VPGLLGLQSYKFGRTTTLVFPDKNYFPTSPYEVIKENKKMGLHTLVLLDVQADKNRYMTA
NEGMKFLLEMEEKNGGNVLSRDTLVVPGRLHFMEVEALIALAHLPAQLGEKLQKI
>A0A7J3UBY9|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MGELIFVGLGLWSEKDITIAGKEAAGTCDKVFAEFYTSMLGVPEEKIEEVIGRPIEVLSR
EEVEDGNAILDEAADKKVCLLTGGDPMTATTHIDLRLRAIERGIDTKVVHGISIMTASAG
LLGLQSYKFGRTTTLAFPEGDYFPTSPYGVIKENMERGLHTLVLLDIGKKLMTTNEGIEL
LMEMEERERGGVIGKKTLMAVVARASSPSPVAKAGYAHELVKENFGPPLHCIVVPGKLHF
MEAKALVMLADAPEEIMK
>A0A842KCG2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLSFIGLGLWDEKDITLKGLEEAKKCDKIFAEFYTSKIGVGIEKIEELIGKKIHVLSREE
VENGKILLEEAKKKRVALLVPGDPMEATTHIDLRIRAIEEGIETKIFHGVSIISASASFV
GLQTYKFGRVISIAKPSKGYFPLSPYENLKENFKAGLHSLLLLDIGMSANEAMEILLEME
KMKKEKVVDENSFIVVIARISSDDAIARANEIKYLIKEDFGELPHSIIFPGKLHFMEKKA
LIKIANAPEKIIEGERDYGATGFGSTHSGL
>A0A7J2M8E2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLSFVGLGLWDERDITVKGLEEVRNCDVAYAEFYTSKMGVGIERIEELAGKKIHVLSREE
VEDGERILHEAEKKHVCLLAGGDTMAATTHVDLRIRAVERGIPTRVVHGVSIVSAAAGLL
GLQVYKFGKVVSIARPQPNFFPLSPYDAIRDNMTMGLHSLLLLDTTGGYMTANEALELLL
EMEERKRENLIGEDTPIAVVARVSSDDALARAGCLGELRKQDFGSTPHSVVLFG
>A0A0T5ZEQ1|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon CSP1-1|TrEMBL
MLWFVGLGLSGIESISIKTQNLLKNADVVYLEQFTSPISKSELTKIKKIVKGEFKIGKRW
IVEDGKEILNNSKKKMVLLLTYGDPYIATTHIELRTRAIQNKIKTNTIHAASSITALVGE
CGLHYYKVGRIVTVMNDLKSMTTPYYAIYENALAGYHTILLLEYNQDAKFFFEPLDALSD
LIKTEKEQKRKVISPSTFAIIASRIGFKNQAITAGKISNLMKKSFGKPPHTIIIPGNLHF
TESDALKVLAECIDVPFDNSKNIKKISNQMLEKYVPMVRKALEEIAPHYQNSKEFQEVLE
NAELYIKDAEKFLAEGKDEVAILSIGYADGLVDALRIAKGLEPRM
>D0KTS1|diphthine synthase|EC 2.1.1.98|Saccharolobus solfataricus (strain 98/2)|TrEMBL
MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEA
DRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTAN
EALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIP
GNLHYMEADAIKWILRS
>A0A0E3NRU0|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. WH1|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVQEADIVYAEFYTSCLMGTNPKKMEHLYEKKVHLLSRE
DVEQQPDWLNEAKDKNVVFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGARIISETPYDTIKLNSELGLHTLVFLDIDKDKGYMTV
NLALALLLEVENKRREKVMDRAVAVGIARAGSEKPVVKADYAENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAAGPEKLMEGIE
>A0A371MCC9|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-10N|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEYVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVESDALSALGGAPEELFDDEN
>A0A7C4PYH0|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MKGKLYIVGIGLTPEYLTIRALKILRRVKKVFLDSYTSLLVDDVKLKEVLGSDYEMLGRR
DLEDLNGEKVFNALNEGDVALLSPGDPLIATTHVNIVIEARRRGYEVEIVPGVSIVSAAV
SFTGLMIYKLGKIATVTYPKDGILYEYPYDVVKENSLRNLHTLLLLEVDVDKSIYMSVKE
AIQILLRIESLRREGVITSDRLAIGISRLGGEDMKVCPDSLGNLMSMDLGGPPHSLIITA
PKLHFIEEEVLKVVKDVYCR
>I3R2Z8|diphthine synthase|EC 2.1.1.98|Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEDLETYHDIDIEVRDRA
GVEQDPEEILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEERGIETHLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRERGLHTLVYLDIKVDWEGRRGV
EVEGDEYMSADYAAELFAEHWDGDALGVAVCRAGCPNPVVAADRLSELAEREFGDPLHML
IIPGEVHHVEADALTSLGGAPESLFDYE
>A0A285FVX8|diphthine synthase|EC 2.1.1.98|Methanohalophilus euhalobius|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNAGKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEINIAFLTGGDTMVSTTHVDIRLRAMEMGIETCLIHGASIVSAICGL
TGLQNYRFGKAATIPYPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMDKGYMTV
NQGIELLLQVDEKRGENLIKGSIAVGIANAGSEKPIVRADFAENLESCDFGSPLHIVVIP
ADLHFVEAESLIKLADAPESILEEGDIN
>A0A7C4SHP9|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MNITFVGLGLGPKRYITEAALDSIKAADVVFLDTYTGILPKETVEFLRTVSKHFVLADRR
LLEDGIETVLAEAAKKDVVIAVQGDPFIATTHVSIMLEARKRGIKCKIVNGISSYSVAAS
LSGLQAYKFGRAVTLPAEGCVEHAKSVYESILENMSKGLHTLVFLDTKDGGLTIPVALKR
LRELESLLRKGLVSDDRLVVALARLGYEDELIKAGRVAEIAATDFPEPPHMLIFPGKLHF
LEREALIRLLGAPREYVEAYEPINYEVDRVKRYIDTCERVLSSLCASAKGTRVNDVLNVA
KSYLDDSKFFLKSGEIFDSLSAISYCEGLLDALRMMGYVEFDWRL
>A0A6V8ELS1|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MISKTDNDFGSSASVDGESGISLDKPSSDEKILCPSASQLFSVIKERAPSTFLFGTNKCR
IMFIMCRRLGRFTMTETSLPAGLWLVGLGPGNLDYMSKYANDIAKSCSKRYLEGYTAILP
PKQEEKLESLIGKWERMMRPDIENPEELLKMAKEIPVALLIVGDPMQATTHIDLEARCEE
MGINFNVVPGITATALAVSLSGLQSYRFGRQVTIPFSYGEYLPHSPLEMICKNYENNLHT
LVLLDLDPTGMGVNNPKPMKPDEAISLLARMAGKILEETSTFEILKKPVDEWDGILLTDI
SMVEQKVTAGNLSQLSKLKEGWIHCMIIPSNMNDNELEAFERRKNC
>A0A1F2P519|diphthine synthase|EC 2.1.1.98|Candidatus Syntrophoarchaeum butanivorans|TrEMBL
MLTFVGLGLYDERDITRRGLEAIRSAEFVYLEEYTSRLGGCNREKLEGVFGRKVLPATRT
DIENDPEEILRRAASSDVVLLTGGDPMSATTHIDLRLRAHDRGIKTRIIHAPSIFTAVAG
ITGLSSYKFGKSATISYPWGERGVISEVPYDTIKINRAHGLHTLLLLDISNGRCMRIHEA
LKILSMLEEKRDEGVVDNLLFVGVARAGSEDMTVKAGDLETLMHFDFGPPLHVLVAVGEL
HFIEHEALVKFAGLKGDL
>A0A7C4E452|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLSIIGLGINCDPTLRGIELMKEADEIYYETYTSPIDISKLNALSKKLGKKFVKLERRDL
EEDVEKFVARAREKKICLLVGGDPLVATTHISILLEAEKQKVKYEIVHNSSILSAICETG
VHSYKIGRVTTIPIKEESFDPESFYEVIEENLKRKLHSLILLEARDETNFVSINEAIERI
LKLSSERGGIIGENSLALAISRLGYSDQIIRFGRLGKLKRLKFGKPPHSLLLLSDLHFTE
EEALSRFLR
>A0A348B382|diphthine synthase|EC 2.1.1.98|Sulfodiicoccus acidiphilus|TrEMBL
MLMPGRLYLVGLGLSSNFLTQATLDALRSSDVIFLDGYTSISCDLNAELISKLTSKEVIV
AKRSQLEDEAKQLLKLAELGNVVSIASIGDPMIATTHAALAVDAMSRGIEVKIVPGISVF
CYAVSKSMLSSYKFGRSVTITYPTGIADVTAIKVIESNFSQGLHTLTFLDIKDDKPMRVS
EAFDVLREQQSRLGRDVLGQFQYVVVESRLGCPDEKVSVISVNEADEDVGSPPYVIIFPS
RLHFMEVDALKWLRFKREYRST
>A0A0F8QX38|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTKPGKMEKLYGKKVHLLSRE
DVEHHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIDTRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A424YQE8|diphthine synthase|EC 2.1.1.98|Methanocalculus sp. MSAO_Arc2|TrEMBL
MLTFIGLGLYDETDISLKGLSLIRSADAIFLETYTSRLMGTDIDRMEALYEKPIRLLSRD
DVELNPDPILDAAESGAAVFLTAGDTMVSTTHADLRIRAADRGIKTAIIHAASIASAVSG
LSGLQNYRFGKSCSLPFPEGKWMPTTPVEVITDNLARNLHTIVYLDIQDTRYMQIPEAIE
IIEEITRSFHQMIPLYVGIARAGSDDPVVFAGNGDDLKYYDFGPPLHVVIVPAELHLMER
EYLERFAGLQKISKASL
>A0A7L4PG71|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLFFVGLGLYDERDISVKGLDAVRRADRVYAEFYTSRLMGVSLDDLERFYEKKITLLSRG
DVEGQPTWLEEARDMDLALLVGGDPMISTTHLDLRMRAMELGIPTRVIHSSTIASAIPGL
TGLQNYRFGRSTSIPFAYTVRGKRIVPETPYRVVQENRRANLHTMLYLDIQDRRYMTVNQ
GIEQLLEVEESLGGGDLASALGVGVARAGSDQPLVRADRLDRLKDVDFGGPLHTLVIPAR
LHFMEARALVVLATAPEEEVRRAEL
>A0A520KMY1|diphthine synthase|EC 2.1.1.98|Methanonatronarchaeia archaeon|TrEMBL
MSLVFIGLGIFDVKDIPVKGLERARECDRLFAEFYTSRLMGSSVGELEDFLGCEVEVLGR
DAVESSDLILDCAEEGDVGFLVVGDSMIATTHNDIRLRALKRDIETEVVHASSIYTAAPG
LAGLQNYKFGRSATVAFPYKGNVPRSGYKAVRENRERGLHTLLFLDIKEDGFMSPSLALE
CLLEVEREVGDGVVGDDLPVVVVGRAGSDDPMVRAGRLGELVEVEWGDPMHVLIVPGDLH
FLEEEALEFFGLD
>A0A662Q0T0|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MPIHLIGLGLGTIQYLTLGALETAERMDELFIDTYTSWIDQDLMRYLEEKFGEKLVKADR
SMLEERIGELIERAEEKEIGILVPGDPLIATTHISIILEARRRNIPAHLIHGVSIISASA
SASGLQAYKFGRITTIPKNGVGIETCYRFVAENLEKGLHSLILLDTADGGLRIPEALRML
MKVEDELGYGIFHPSNLVICLTRIGSGEEFRWAGKISDAIEIDYPPPPHLIIVPGELHFV
EAEALKEILRADEELVKSYRPPRYEKGRVQSYISKVEKVLSEVKIRMSSEKVIDSIEIVK
SYLEDSKKFLENGEVFNALAAISYAEGLLDSLKNIGYIDFDWPKT
>A0A843BBL6|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGLGVCPPGSIPADAARILESADIIYLETFTSPVEPSACVAGARPAPRWMVEDGRE
ILDNAERSTVALASYGDPMVATTHAELRARAVSRGIRTGVVHAASVASAVFGECGLHHYK
AGRTATIMDDAKATLTPYQTTYRNAVSGNHTLLLLEYDVGRGFFLDPGAALRMMRGAEAG
QKRGVFAGDTYVVVASRVGMPDQAIRAGRLDTMEGRDYGGPPHSIVVPGPLHFTERDALL
ALAECSDEPPPEGHAIQSIPHQMMQRYAPAVRRAADSIPDPDRYRTILENALLYVRDAER
ALEEGHDEVAVLSIGYADGLVDALRMQLNLGEWSPDTKM
>A0A533W8R8|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MMGRLTFVGLGLGARGISLEGVVAVKEADSCYLEYYTTPHEPTLLKELENETGRVMTVVD
REFVEDGREILKEARGSRVVLAVPGDPMIATTHNELRVRAIGQKTETAVIHAATIPSSAA
SASGLHYYKFGRMMTITRETLDSMQQAYHTLQTNLLQGLHTLLLLEFDVEGGEGAAPPAV
IGGLLRAEKNFGREVLTEETFALVLSRLGRQDSELRAGYLKDLRNSEYGEKPHCIVIPGG
LHFTEVEAVAAIFGLGEGEVRDNSRNMKGTAEVLIPRYAAKTRRALNSARERLGRDYDTL
LENVELYTKDAEGFLARGEHELAMLSMGYAEGLLDSAGFTGRAKIDW
>A0A7C5TY58|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MVSSKERCVKLYIIGLGLYLKQITLEALEILRDRCEKIFAEEYTSISSRGGIEDLEKIIG
KKIIRVSRKDLEDLNGEILLKNLRENVDTCLITWGDPMTATTHVSIAKRAVEEGFCIRYV
PGISSIHAALGFTGLMIYRLGKISTITFPKDNILSEYPYHVLRENMIRGLHTLYLLDIDV
EKKIFMRASDAVRILLELEERFRENLFNEKSFVLGIHIDEDTIICGGEAKFMLKDPLKEV
PQILIVPSKLFVTEDEYIRSLGLKYDRCITIS
>A0A6V8EFI5|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MDGSGLWLIGLGPGDLNHMSISALSAAKAANYRFLEGYTALLPPEELGNLEEVVGPWELR
MRSSVEQPEELLDLAQNHRVALLVVGDPLQATTHVDLQLRCAQRQIPCHIEHGISITTIV
TGAVGLQSYRFGRQCTFAYPYGDYLPISPLEIILENKERGLHTLALLDLDPTGMGEGDQQ
PMTPKVAIEVLRNMAQKLGVDIEGWTLVLCSDMGTDDAKVNVGTAQQISELTSGRIHCLL
VPAELHDVEDAALARW
>A0A7M3WE52|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MASDEVPAGLWLIGIGPGDLEHMTERARSVARRCKKRYLEGYTAVLPTEQEALLESVVGP
WERMMRPSVESPETLLAESRNDSVALLVVGDPMQATTHIDLEARCMEEGIGFEVVPGMSA
TSLAVSLSGLQSYKFGRQVTLPYPYGDYLATSPLEMILRNLESGLHTLVLLDLDPTGMGV
DLPTPMSPSQAISTLEEMSSKWLEEGDGLDSTSVVVNEWEGMLLSDVGTKGQRVFSGSLE
EISKIQYGWVHSLIIPSEMSDNEREAFSRRGAM
>A0A6B2CP50|diphthine synthase|EC 2.1.1.98|Acidilobus sp|TrEMBL
MLFIVGAGLGPQHVTDLAKSLIKRAEVVIIEAYTSPNSGWLEDLAKALNKATVKATRDLL
EENVNKLIDMARDRDVVVLVAGDPLIATTHSSVVVEALTRGVKVKVIPSVSGPCAAMSLS
GLQFYRFGRKVTVPGPWRGVDVTPVAYWLLGNLCLDLHSLVLLDVDQEGRQLPPADGTRE
LLKAFNELLSDQGEDLGDLLVLAVSVTDNDVYVTYSRLSEPEALRPITPSTMIVPASLHP
VEQEFLKLVHGVPSGLIDLHLKLLRRIDPCNLYFSARHKVMASP
>A0A7M3X6C4|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
AEAVEAAKAADVRRYEAYTALWPRSELDALEAAVGSIEKVMRPEVEQPDVLFELAHTSLV
ALLVVGDPLQATTHVDLQLQAAEAGIECRVFHGVSITTLVTGAIGLSNYKFGRQTTLTYP
YGGWVATSPLEVIAVNMHQNLHTLALLDLDPTGEGVGNQVPMKPSDALVSLRLMWDKLGQ
MLDEMPRETALEAMRHEACAVFLARSLDDVHVVLCADMGTDDERMVATTVGALDGIEGGR
LNSLVFQSTASEVEERALLRWE
>A0A1G7GSA7|diphthine synthase|EC 2.1.1.98|Halorubrum xinjiangense|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEAYHDVDVEVRDRD
GVERNPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADNWGAELAVVVARAGSPDAVVAADRLRALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVEE
>A0A1J4RLI1|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon CG1_02_38_14|TrEMBL
MLNLMGLGLSDEKGLTLEGLETLKKSDKVYIELYTSKWFGSIENLEKMTGKKIMQLKRPD
LEENLEKILKEAKNQTISILILGDPLVATTHTALLIEAKKLGIKTRVIHNASIYSAAGET
GLHLYKFGATVTIPFLEKMNNQFPESLSKIIRDNKGRDLHTLCLLDLISEKEKYMTPSEG
MEVLLKSDDITQEDEIVIFGRAGSEEPLIAYGKIKNLIDKDFGNPPFVLIILGKLHFTEK
EYLEYHRAD
>A0A5P8LYR7|diphthine synthase|EC 2.1.1.98|Halomicrobium sp. ZPS1|TrEMBL
MLTFVGLGLYDERSITVEGKEALQTATDIYAEFYTSKLIGTTIQKLEYYHDIDIELLDRA
AVEQTPDELLAAAEDGDVAFVTAGDTMVSTTHVDLRLRAEERGIHTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVETITANRERGLHTLVYLDIKVDDPHWEGE
QEFMTADHAAGLLADHFDTLGVVVARAGSANPVVEADSLDALADGDYGGPLHLLVVPADL
HEMERDALTTLADAPLAD
>A0A0A7LCX4|diphthine synthase|EC 2.1.1.98|Candidatus Methanoplasma termitum|TrEMBL
MRSGIVFVGLGLSGTDGMTVKGLNALKECDKIYAEFYTSTLIGAAIGDIESAIGKKINMV
HRTQVEEEEFIISDAKTMVVGFVTAGDTMLATTHVDLRIQAEEEGIPVKVIHGVSIFGAC
PSSLGLQPYKFGRTVTLPFLESGYQPKSPYDNIKQNKDRGLHTMILLDIRADELRYMTAH
QAIEWLIEGEKKWNEGLITDRTVICVVSNAGSENEKLFAGYPQDLLKKDLGAPLQTLVIP
GNLHFMESYALVDFAGAPKEIIENEDE
>A0A1V6N3B0|diphthine synthase|EC 2.1.1.98|Methanobrevibacter arboriphilus JCM 13429 = DSM 1125|TrEMBL
MLYFVGLGLFDEKDISLKGLKALKSVEIVYAEFFTSHLFGSSFKAIEELIGKEIKVLNRH
EVEEENVFMKEAIKGRDVALITGGDPLIATTHTDFLVEAKKKGIETEVIHGSSILSSAPG
ISGLQAYKFGKVTTIPFPDENFFPQSPYMAIANNLLNDAHTLVLLDIQAHKNRYMTVNQG
LEYLMKVKDDLISNGKDNEAIIDENTLAIGIARVGSKDVVVRADKIGELIDFDFGGPLHC
IAIPSKLHIVEAEYLVEVCGAPREILDEI
>A0A2I0QE31|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon HGW-Altiarchaeales-3|TrEMBL
MMLYIIGLGIYDEKDITLGGLEILKKCKHIYAEFYTNLWHG
>A0A842KRV6|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
HSPYLTIKNNLKYDAHTLILLDIKAEENKYMNANQGLKYLLKVEEERKENIISLDSLAVV
LARVGSSNPLIRADRIKKLIVEDFGGPLHCLIIPSKLHFLEAEYLIEIGRAPPEILEGRI
>A0A846SWF2|diphthine synthase|EC 2.1.1.98|Nitrosarchaeum sp|TrEMBL
MVLHLIGIGLCGEKDLSVRALECVRAADVVYVEGYTSVLQVGVEELERFYGRMVKVLGRE
AVESGLDDLLEQARQQEVALLVVGDCFGATTHAVILAEARRKGVQVRVLHGASILTAVGV
TGLELYKFGKVTSIPFRTEGVGTPYEVLASNHAAGLHTLMLLDLDPGSGRFLSVGEAARY
LLEAELRFGRGVVSPDSEVVGCARLGCPDQVVRYAPLRSLAVAEFGAPPYCLIVPGRLHF
VEEEVLALYRG
>A0A843I5M1|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFDKIEELIGKEIEVLVRG
EVEEEHKFIEEAKNCDVALITGGDPLIATTHSDFLVQCAKKGIKYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYVAIEENLKSNLHTLVLLDIQAHKDRYMTVNEGL
DYLMNIKDSLDYDGLITEDTLAMGIARVGSSDVIVKAGKISELIDYDFGGPLHCVVIPAE
LHIVEAEYLVEIAGADSSILDDV
>A0A7J9SG70|diphthine synthase|EC 2.1.1.98|Halobellus ruber|TrEMBL
MLTFVGLGLYDEESITVEGRAILEDADRAFAEFYTSHLVGATVDDLSAFHDVDIEVRDRA
GVERDPEDVLAAAADGHVAFLTAGDTMISTTHVDLRLRAIDRGIDTRVIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPSAHGGGDVPGSVVESIDANRERGLHTLVYLDIKADRDAYLTA
DVAAGLLAEGWTDTLGVAVARAGSPEPVVAADTLSTLADRDFGDPLHLLVIPGDLHHVES
DALATLGGAPADALAARER
>A0A7C5L724|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
MVDQRFAGNRQNVLRPVRGQRHQPLSITSGEDNSLQPRIHYNQLNITVIEMVLLLVGGGL
GGRGSLTYDAEKALRECDIVYVDTYTSIWSDDLLVYVKNIVRKLVMADRKTLEDDASRIV
NEARENVVGVLCPGDPLIATTHAALWELAARRNVQVKIVNGVSIVSASISVTGLHVYKFG
KLATVPKSDNVDMHFQALVTLEENLSRGLHTLLLLDTASGGLTAAEAVEKLLHAAEQTGK
KVISGDTLSIVIARLGSENASVKAGLAKDIVKLSLPPPPHSLIIPSSLHFTEREIVKTYA
IGPEVLEKAVILNPFASRMHRYVEKCRNILNHVLQQKRFEQYVNYVKNYVDDAEKFMLSG
DMVDSLLSIGYAEGLLDALRLMKEVDFKW
>A0A7G9YQA0|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MLTFVGLGLYDEEDITLKGVRAIKDADMVFAEFYTSKMMGTTIERMESRYQTKITTLSRG
EIETDPSWLHHAIDQDVVLLSGGDPMVSTTHIDLRLRASDLGIATVIVHGTSIASAAAGL
AGLQNYRFGKSATIPFPYTVRSKTIVSETPYNTVLLNRDNDLHTMLFLDIDPDKGFMMIS
EAAQLLMQVDERGLLDRALGIGVARAGSPDVVVKCGYLRDLAGSGFGAPMHLLIVPAGLH
QMEAEALVRFAGAPEEIIER
>A0A7D7V5X3|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFIGLGISGFKSIPMEAIDVLSNVDIVYLEQFTSPIGKSDLSKIKNAVKGEFKLAKRW
LVEDGKEILKNAKKKKVALLAYGDPYIATTHIELRTRAIEEKIKTHSIHASSSITSMIGE
CGLHFYKIGRIATIMSEMSLTTPYYVIYKNIIEGNHTVLLLEYNQDKNFFLDPKDALCDL
LETEKGQTRKVISSSSYAIVASRIGFKDQKIISGNISSLKKMDFGKAPHTIIIPGRLHFT
ETDALKMLGQCLDEPYDNTEKVKKISNQMMKKYVPMVREALEEVIPLYKEQKEFHGILEN
AELYVKDAEKFLEDGQEEVAILSIGYADGLVDALRLAKGLDPKM
>A0A075I3L7|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_14_E04|TrEMBL
MQNAELYINDAEDFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>A0A371KG89|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-48N|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A117LVT2|diphthine synthase|EC 2.1.1.98|Methanocalculus sp. 52_23|TrEMBL
MLTFIGLGLFDEHDISLKGLAVIREADAVFLETYTSRLMGADMPALEALYQQPIRLLSRE
DVEQHPEPILDAAESGSAVFLTAGDTMVSTTHADLRIRAAERGIRTTIIHAASIASAVCG
LSGLQNYRFGKSCSLPYPEARWMPTTPVEVIAANRSQNLHTIVYLDIQKERYMRISEAIA
IIEEIGARLTITIPLYVGIARAGSDDPVVIAGTGDDLKRMDFGPPLHILIVPADLHMIER
EYLELFAGLPPESDSIQ
>A0A842LQS6|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp|TrEMBL
MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRSVKVLGRG
EIEEERIPLERASELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGL
AGLQAYKFGRIITIPFTADNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTASEGL
MYLLKASEKLDDDTISGETLAVVIARAGSEKPLVRADRIDALVDEDFGDPLHCLVVPAGL
HFIEAEYLVEIAGAPRAVVERMII
>A0A7J4N9C0|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniia archaeon|TrEMBL
MLTLVGLGLGGPESLTQAGIAAIREANAVFAEGYTSPLLPETLAWVEQEAGKVRLLSREE
VEQPETLLAAARDDATVLLVGGDPLAATTHVSLRLQCREAGIACHVVHNASVLTAIAGEL
GLQHYRFGPVATLVLPEGDYRPLSPVERVLQNIEAGFHSLVLLDIRADDPAAEPRLMTAA
EGAALLLEGGVGTGAQACAAARVGRSDQQLWCGTLGEMAQAKIGEVPHSIVIPGELHFVE
EEALAALQE
>A0A7J4DX01|diphthine synthase|EC 2.1.1.98|Pyrodictiaceae archaeon|TrEMBL
MLYLVGFGPSARFLSIAALQALAHADKVYVDVYTSFAEGFSLELVKSLAPSAEVVEASRK
ILEDLSHKIVDEAKRANVVVLVAGDPLTATTHNALWLEALKRGVKVEVIPAVSGVQLAIA
VTGLSWYRFGRPITLVYPEEHYKPYSTIEVIVDNLERGLHTLVLLDFRVDQGKIMDVKTA
VKLLFELARELNGKDFLERLREAIMVGIARAGFRDQKCVAGYSRDILDSKFPPPPHTLIV
AHPRLHPIEEDLLRRLCGFKGSNY
>A0A7K4FS80|diphthine synthase|EC 2.1.1.98|Acidianus sp. RZ1|TrEMBL
MGDLYLIGLGLSKRFLTNASIESMKRSDVIFLDSYTSLSCDLSKDVLEEIIGKQISIVKR
EDLEQGYRNIIESLKTKNVAIATVGDPMIATTHVGLAVEARKNGYNVRIVPGISVHCYII
SKSMLSSYKFGRSVTLVYPYEGKTDMTTYNVIKSNQEAGLHSIIYLDLRDGKPMDGNEAI
NLLLSMESQRNEGVIRLDDVLVLGERLGCDEERVFALSFREAIKVNLNRPPYIIIIPSKK
LHYMEVEALKCLH
>A0A1D2QWR0|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon WOR_SM1_86-2|TrEMBL
MLYLIGLGLYDEKDISIRGLEILRECDEIYAEFYTNRWCGNLKNLGLKKARVLIRKDIEE
NPGENVLKNCKGKKVALLVPGDPMIATTHIDLVLRAEKLGVSVEIVHSSSVCSAISETGL
QAYKFGKTASIAFPEKDYFPESFYNVLKENLELCLHTLMLLDVKSEENRFMSVNQAIEIL
LEIEDKRGDGVFTEKTRCVGCARLGSRRRVIKEGSAHDLLNCDFGLPPHCLVVPGELHFM
EEEALVRFRIF
>L9WUU4|diphthine synthase|EC 2.1.1.98|Natronolimnohabitans innermongolicus JCM 12255|TrEMBL
MLTFIGLGLYDERSITVEGQAALRSADRAYAEFYTSKLIGTSVSDLEAHHDVDIEVRDRA
GVEQHPEEILEAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIDANREEGLHTVVYLDIKVGQGPTSSQ
NAKRSDDKVGHERTEDDEYMTADVGAELLAEEYPDLVGVVVARAGSPDPLVAAGTMTDLA
EREFGEPLHLLVIPGECHLLEADALVELAGADRDALDVV
>A0A498G9F4|diphthine synthase|EC 2.1.1.98|Haloarcula sp. Atlit-7R|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDLETLEDALETSIELRDRA
GIEQDPEPILEAAERESVVFCTAGDTMVSTTHTDLRLRAENRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASQAAAMLSEPFPDTHGVVVARAGSPEPLVVAATLDELATQTFGDPLHLLVIPG
SLHPLEADALESIAGAALE
>A0A2H4U7E0|diphthine synthase|EC 2.1.1.98|Methanobrevibacter smithii|TrEMBL
MFLKSYIMFYLVGLGLFDAGDISLKGLECLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDYNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIIIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A0C5BV21|diphthine synthase|EC 2.1.1.98|Nitrosopumilus piranensis|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPIGKSDLIKIKNVTKGEFKPAKRW
LVEDGNEILESAKKKKVVLLSYGDPYIATTHIELRERAIKEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LLETEKGQRRKVISPSTFAIVASRIGFKDQEIISGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGKCDDEPFDNSEKTRKISVQMMEKYVPMVREALEEVEPYYKDQKEFQTILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A7J3M0J3|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus|TrEMBL
MLTLIGLGLGDEKDITIRGLEAVKDADVVYAEFYTSKIFASLEALRKFLGKEIRLLSRED
LEERVGSLIEETKRKKVAILVAGDPTIATTHVAILLEAKKKGIETRVINNASIINAVCSL
TGLQNYRFGKSATVSWHRSRAFIDVIKANLSIDAHTLLFLDLNPPMRICDAIERILELEK
EFENHFAVGIARAGSESAVVKCDRLKSLLDFDFGDPLHTLVILARKLHFMEYECLRFFAS
APEDLKEWIT
>A0A256ZUC5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon ex4484_218|TrEMBL
MGLGLHYEKGISLAGLEKARKAEKVYVEFYTNPMPYLSMENLQKFLGKPIIILKRKDLEE
KAKEGILKDALKMDVALLVPGDPMVATTHVSLRIQAYKMGIKTEIVNGVSIYSAAPSIVG
LQIYKFGKTVTIPFPTLTYKPQTPYDVIKENFVRGLHTLVLLDVDYEKGKCMNIKDGLEY
LLEIEKERKEKIVTFDRLVVGVAGVGSPNPIIKGNIVKKLLNYQFKMYPQTLIFPGKLHF
MEVEALKIFAQTPEEALKPYEE
>A0A7J4PJH1|diphthine synthase|EC 2.1.1.98|Methanosarcinaceae archaeon|TrEMBL
MLTFIGLGLFDEHDISLKGLEAVRAADLVYAEFYTSYLMGTTPEKMEELYGKEVRLLSRE
DVEQQPDWLEEAKTKNVVFLTGGDTMVSTTHVDLRLRAKKLGIETRLVHGASITSAVSGL
TGLQNYRFGKSVSIPHPYESKRGVLVITETPYDTLKQNSERGLHTLVFLDIDKDKGYMTV
NRALELLLEVEKRRGEGVMTRAVAVGIARAGSKQPVVKADYAEELQNFDFGKPLHILVIP
GKLHFLEAEALVELAGGPGAILKEAE
>A0A6B1IG04|diphthine synthase|EC 2.1.1.98|Halorubrum terrestre|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A7C5X939|diphthine synthase|EC 2.1.1.98|Pyrobaculum sp|TrEMBL
MLHIVGLGPGPGYATEAALKAIREADCVFYEDYTGPLDLETLRRTAAREPVKLTRKDLED
ESGRRIFECLREGKRAVLVTAGDPALATSHHALVALARARGYPVQILPGVSIICAAFSVT
CLSIYKLGGVATVTYPRGGVYSRRPYELAEQNLRRDMHTLLLLDVREDGSFMPPRDAAEI
LLRLEEEEQRGVFTPDRHVAVVYRLGWGGSVLYTRLKDLLSAEAGGPAVVIVPARLNPVE
KECLETTSKGITI
>A0A8J8EHY0|diphthine synthase|EC 2.1.1.98|Thermococcus sp. ES12|TrEMBL
MAIYFIGLGLYDERDITLKGLETARKCDLVFAEFYTSLLAGTTLDKIEELIGKPIRRLSR
EEVELHFERIVLSEAKERDVAFLTAGDPMVATTHADLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTMLFLDIKAEQNRYMRANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLNPTLKAGYVKDMLNEDFGGQPHVMVVPG
RLHIVEAEYLVAFAGAPREILAKV
>A0A7C5EB17|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MVFVGLGLETGGMSIRGLEEVKRADAVYAELYTNIIPGLSAEELARLIGKRVKVVDRKTV
EEDPEEILEAARRGGGGFLVPGARMDDTKSE
>A0A7J3TY77|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKTGELIFVGFGLGEGGLTLKGLEAVRSADEVYVETYTNYTPEHVLRRLENASGRIFRRV
SREDLENLGRKLILDKAAEFKVVLLTPGDPFTATTHIALRLEAEKRNIKTSVINSSSVVT
SAAGACGLQTYKFGETATVCFPNGGAVSTKPYETTFYNLARGLHTLLLLDYRAHENRAMT
VNEGLEILREIENLKRMGVFTEDRLVVGLARLGYDDFKVKGGRLDEIIREDFGEPPHCII
VPGALHFLEIEALMKLAGVKKSHVENIPRFRGFIELDVLDRYINGVKNVFREMKILGESR
EMSNRELDLALEWARNYYSDSIAFKLKGDLVSSLTAIAYCEGILEGLRLLKFVDFKWEGE
R
>A0A7C4DG76|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRTGELTFVGFGLGEDGLTLRGLEVVKSADEVYIETYTNYTPEEVVKKLENISGRNFRRV
SREDLENLSGKSILDRAIKSKVVLLTPGDPFAATTHIALRLEAEKRGIKTRVVGSSSIIT
SAAGAIGLQIYKFGETATICFPNGGAISTKPYETTFYNLARGLHTLLLLDYRAFENRAMT
VNEGLKLLREIEEEKQMGVFTEDRLVIGLARLGYENYKVKGGKLGELIREEFGEPPHCII
VPGALHFLEAESLMYLAGVSRSLVESIPRFRGFVEVDILDKYIFGVKNVFREMKILGETR
EMLSEKLNLALEWARNYYNDSIAFRCKGDLVSSLVAIAYCEGILEGLRLLKLVDFKWEGE
Y
>A0A419JXT1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MFVGLGLYDEKGISLKGLEETKNADAVFVELYTSLMPNLSVKNLEKIVNKKLHVVSRKQL
EEENGKIILDVAEKGKAVLLVPGDPLVATTHIALRIEAEKRGIRTRVVHGASIISAVIGL
SGLHNYKFGKTVTIPFPSETPPETCYNVIAQNKGLGLHTLCLLDIKAEEKRFLSIREGLE
ALLKMEEQRREGIVTMETLAVGIARAGSDNPAVKADYVKELLNYDFGKPPYSIVFPGELH
FMEVEALIVLADAPEELRKFVK
>A0A7C4M1H6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVFSSGVRMGELIFIGLGLHSCLDISLRGIEEIKRAEHVFAEFYTSLMPGFRIEDFRRIT
GKDMMVVSRKNIEEEGGEIILKRALDGRVAFLVPGDPMIATTHIALRIKAEKMGIKTRII
HGASILSAAIGLSGLQNYRFGKSVTIPFPEGSIISQTPYTVAFENKLRNLHTLCFLDIRA
EETKYMSIREALEILMRLEEINKLGLLKEDSLAVGVARAGSENPIVKADAIKNLMKFDFG
GPPHTLIIPADKLHFMEAEALIVLAGAPKWVMGMVG
>A0A419KYJ5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGGLVLISLGLSDERDMSLRALEEARRCDLLYAELYTTLLNTDVERLSRLLGRDVTPLRR
RDLEEGAERVLREAEERRVGVLVGGDCLAATTHISLLLEAKRRGIETRVIHGSSILTAVA
ETGLSLYRFGKTVTVPLPQRGIPPLTPYRVLGENLERGLHTLLLLDLDVEGGRHLTVNEA
MRLLLGVEEEECKGVFTEETLAVGAARLGSESATIKGGRVRRLLDMDFGPPPHVLIVPGR
LHFLEEEALKFFAGCREEDLRGRERYLEDLEARTEKYIRSCEKVFGELRISSLPRSIDEE
GVREILGYAEMYLRDAKYYLEEGRKASALSSVSYCEGILDTLRMLRFVEFDW
>A0A537ET72|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDSVAFLVPGDPMIATTHISLRLSLSKAGIGSRIIHGPSIMSA
VCGATGLQSYKFSKTVTVPYDPPLPASILETISDNYGRGLHTLLLLDVEADLNKQLTIAD
ALAKITSANPSLETRLAVGVARLGSRDEKVKASRIGRLVTEDFGGPPHSIVVVGRLHFME
TEALRIICGAQDSDLRENS
>A0A7C4FBX3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
SYTSILSNSDLEDIIGRRIFKLRRADLEERFEDVLFKPVLQGLNVALIVPGNPLDATTHV
SIIVEAYRRNIVFEIVPAPGIIPNALSMSGLMVYKIGKITTLTYPKNGFLSDYPYDVIKD
NDLRNLHTILLLEIDVENNVVMSIRDAVDILLKLEDRRGEGVISMERKAVAVSGLGGSNQ
RICFESLNKLKTLPEHKGPHTLVLTSPKLHFMEEEALKALSS
>A0A537ERB4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGSALIARRGCLSKVFKRQLEDENGREIILAAEKKDSVLLVPGDPLVSTTHVSVRLSLAE
RGINSRIIHAASIVTAVCGATGLQNHKFGKSTTLPNSTLVPSSIIDTVLNNKDRGLHTLL
LLDTDRGKGSSLSIGNALLLLGTVLSELDDWLVVGAARIGSPDEKVRAARGRELKAVAFG
DTPHTIVIPSRLHFMEAEALKVCSGASDTDLEDYR
>A0A8J8CXW6|diphthine synthase|EC 2.1.1.98|Halostella sp. JP-L12|TrEMBL
MLTFIGLGLYDERSITVEGRDALRAADRAFAEFYTSTLVATTVEELEEYHDTPIDVRERA
GVEQDPAEILDAAESADVAFLTAGDTMISTTHVDLRLRAHDRGIETRVVHGTTAQAAASA
LTGLQNYRFGKATTLPFAYAHGADGLPASVTETIDANRERGLHTLVYLDIKVDNAAAIAR
AGDEELEEYMTADTAAGYLAEEYPDALGVVVARAGSPDPTVAADRLDALADGSFGGPLHL
LVVPGDLHHVERDALADLADAPAELLD
>A0A7C1E6F2|diphthine synthase|EC 2.1.1.98|Fervidicoccus fontis|TrEMBL
MDNPSDACRGELYIVGIGLHPKMITLEALEAINKADSVYLETYTSPGVDEMTSFLEKIRL
GERITRLTRKDVEEQGAREIINKLRNGEKVCFLVYGDPFVATTHNALRLEALRLGCRVNY
VPGISVYHYSISATGLFNYKFGPSVTVVYPRWGIKFTSPYMTINENLERGLHTFVFLDID
EKLGPMTPDIAAKLLLEASTEFEKRNLNENSVVLVLEKMGGPDEKIYCEKLGGLLNKRWG
APPYSLVIPSKLHFMEKDVLLSIGLGCNKLF
>A0A256Z5I4|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon ex4484_42|TrEMBL
MSKLYIIGTGLAPDLITLRAIEALKSVKSVFIEQYTGLLMLNENIKEILKDKEVRRLSRR
DLEDLGGKEIFDSLKDGDVAILVPGDPLVATTHTSIIVEAYKRGYKVEVVPGISIIPNAL
TMAGLMIYKMGKPVTLVYPKEGIIYDYPYDVIKDNDSRNLHTVLLLELDMERNVIMKVNE
AVNILFMMEDIRKEGVVKPTRKGVAVAALGSKNQIICFNTLENLKKLPINEIPQTLIITS
PKLHFMEEEMLKVMNNEYCKPLK
>A0A6B9TCA3|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp. THM-1|TrEMBL
MLYIIGLGLYDERDISLKGLEAVKGCHEVYAEFYTAMLQGSSLSAIERLTGKDVRVLRRE
EVEEDRVPLQRAEEVDVALLVPGDPLIATTHTEILVDARRRGIETRVIHSSSIISAAPGL
AGLQAYKFGRIITIPFTEDNYFPLSPYLNIRANLENSSHSLVLLDIQAHRERYMTANEGL
SYLMKASGELDDDTIGGDTLAVVIARAGSEEPLVRADRIMDLIDEDLGDPLHCLVIPAGL
HFVEAEYLVEVAGAPRILLRG
>A0A327GZA1|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MVPKDIAPGLWLIGIGPGDLDHMTSKAKRIARGCKKRYLEGYTAVLPSEQEALLEELLGP
WERLMRPSVESPEALLVEAREEAVALLVVGDPMQATTHIDLEARCMEKGVGFEVVPGMSA
TSLAISLSGLQSYKFGRQVTLPYPYGEYLATSPMKMILSNLDSGLHSLVLLDLDPTGLGF
DLPTPMSPAQAVSILERMSEVILEETEGMEVLGNIGEWSGILLSDIGTSRQMVRSATLEE
IGKLEDGWVHTLIIPAKMTGNEKDAFERRLIS
>A0A0P9EE53|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon BA1|TrEMBL
MGELVFVGLGLYDERNISLRGLEEARGADAVFMELYTSFMPELALEKLEKLVKRAISVVS
RRDLEEDGGQLILREAGRGKVVLMVPGDPLIATTHVDLQIRAERTGIKTRIVHGASIISA
VVGLSGLQCYRFGRSVTIPFSEDGFVSETPYKVIAENKKRDLHTLCFLDIRADEKRYMTI
NDGLRQLLAVEKRKGKRLICSNTLVVGIARAGSIKPTVKAGYMEDMVRYDFGPPPHTIVF
PGKLHFMEADALITLAKAPEQIREMVK
>A0A7K3Y652|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLYDLGDISLKGLECVRNADAVYLEAYTSRLMGASVVDMEAFFGKEIRVLGRE
DVEQTPDDIIERATRGRVAFLTGGDPMVSTTHADLRMRAAAAGVATSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTTPIETIAANLDRDLHTLVYLDIQEDSYMRIDDAIT
IIEEMAGMRGIEPPALYVGIARAGSACPVVAAGSGARLKEIDFGPPLHILIVPAGLHPME
QEYLEVFAGL
>A0A7L4PUB8|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLYDQEDISVKGLSCVKKAQSVFLEGYTSRLMGTKICEMEEAFGKPIRVLNRE
DVEQHPEKILERARDEDVVLLTGGDPMVSTTHADLRIRAVREGIETRIIHAASITSAVCG
LSGLQNYRFGKSCSIPFPAKGWFPLTPLETIRMNMGMNLHTLVYLDIQPDRYMLVPEAIG
FIGEMASRMGCEPPPLYVGIARAGSSAPVVAAGTGEALLKVDFGPPLHVLAVPAELHVME
REYLETFAGL
>A0A7J4QAX5|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MALYIIGLGLGSEKDITEKGLEAVRNCNFVYIDTYTSILPAEIKKLEDFYGKKLIPATRD
IVEKQAEEEILKKAVENDVAFLVVGDVFSATTHVDLALRARKAGIKLYLIHNASILTAVG
DTGLSLYKFGKITSIPFENKDIEAPYDVLKENAGMHTLFLLDLKVEENKTMSAKEAVDFL
LKVEEKRKEKFFTEETMCVACARLGFEDEEIVYATAKQIIKEKLSKFPQCLIVPGKLHFM
EEEYLKGFEVK
>A0A0F8S8B1|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 1.H.T.1A.1|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRGESVMDRAVAVGIARAGSEKPVVKADYAETLKDFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMEETE
>I3TEI6|diphthine synthase|EC 2.1.1.98|Thermogladius calderae (strain DSM 22663 / VKM B-2946 / 1633)|TrEMBL
MLLLLVGIGMKYEDLTLQAIQAIESADLVIIDTYTSIHEDINRIIELIGRKEVRLAKRSD
LEGVGIERIVEEAARRKVAILVPGDPLIATTHEAIRVEAAKRGVEVKVVNGLTVVSLAFS
RSGLHFYKLGRTVTLTYDPSSVDYVLRVIQDNTSRGLHTLILLDWRAEESKAMTVQEAVS
MLLEGDKEGLLAGRVGVGLARLGFSDEYMVADLVPNLGGYEYPGPPHSLIVTGDLHFMEV
ESLRYNCGLPEKLYERLVKRL
>M0GM16|diphthine synthase|EC 2.1.1.98|Haloferax prahovense (strain DSM 18310 / JCM 13924 / TL6)|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEYVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVESDALSALGGAPEELFDDEN
>A0A1H3IW22|diphthine synthase|EC 2.1.1.98|Halopenitus persicus|TrEMBL
MLTFIGLGLHDERSITVEGRDALRAADRAFAEFYTSRLVGADLADLEDYHETTIEVRDRA
GVEQDPEPILAAAESGDAAFLTAGDTMVSTTHTDLRLRAEDRGIDTRVIHGVTAQSAASS
LTGLQNYRFGKAATLPFPYAHGGDGVPDSVIETIEANRERGLHTIVYLDIKVGTGPRGPD
PDHEEYMTADRAAALLADDWADVLGVVVARAGSPDAVVAADRLSALADRSFGDPLHLLVI
PGDLHHVEADALAGLADAPADLLS
>A0A842LVZ9|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylicales archaeon|TrEMBL
MGSLSFVGLGLCDEKGMSLYGLELARSADIVLIETYTNIMPSLNIRSLEALIGKEVKMVD
RHYIEDGSHLLRTASEKDVALLVPGDPFIATTHVELRVRAERRGILVRVAHAPSIISVAP
GVVGLQNYKFGRSATITFPDNYSEVPYDTIIQNRRAGLHTLLFLDLRAEEGRYMSVQEGI
RLLMEMESRRGEGAVCPDTLMIGIARAGSPDQLVKGGRAEDLASLDFGPPPHSLIVPGRL
HFMEAEALEVLARVDRSLLSKYVERV
>M0I865|diphthine synthase|EC 2.1.1.98|Haloferax mucosum ATCC BAA-1512|TrEMBL
MLTFIGLGLYDEQSVTVEGKEALADADRAFAEFYTSHLVGATVEDLETYHDIDIEVRDRA
GVEQDPEAILDAAEDEHIAFLTAGDTMISTTHVDLRLRAEERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVIDSLEANRERGLHTLVYLDIKVDWEGRRGV
EVEGDKYMSAEYAADLFATHWDADALGVAVCRAGSPNPVVVADRLSELAERDFGEPLHML
VIPGEVHHVEADALSALGGASESLFDYE
>A0A895A4W3|diphthine synthase|EC 2.1.1.98|Halobacterium sp. GSL-19|TrEMBL
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHVERDALRELAGAPADAL
>A0A256JYU5|diphthine synthase|EC 2.1.1.98|Halorubrum ezzemoulense|TrEMBL
MLTFIGLGLCDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLTEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A849R113|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLYLIGLGINDEKDISLKGIDAIKSCDAVFAELYTCPIHADLSNLEKLTSKKIQLLNRKQ
VEEDELVLKSAKSCDTAFLVGGDALSATTHTEIILDAKKAGIDVKVIHASSIFTAIAETG
LMLYKFGKTVSLPIPQENYFPTTPYTNIKDNLDSNLHTLLLLDIGMSANKAIDVLLELEG
KMNGKLFSDSSKLVVVAHLGGDSLIKYDAISNLKKMDFGIQPHALIIPSALHFHEEEFLE
LF
>A0A6A8AW74|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MTLTLISIGLTDERDLSLRALEEARKCDILYAEAYTTILDTDIKRLSALIGRPVEPLPRS
AYEEASHQLLSKAEDTNIGILIGGDALSATTHISLLLDARKRGIPTKVIHGSSILTAIAE
TGLSLYKLGRTVTLPLPEKAPPDTVLKTLDENREHGLHTLILLDLDTQADNYLSIQQAIT
TLLEAERPDTYDEDTLTIGVSRIGWDSAEVKADTALKLKDHAFSGPPQALVVPGDLHFLE
AEALKVLADCPPGLLEGRKVTGEVQRLIEKYGTSCRRAIEQLEYAELPKGVTREEVKALI
EHAFRYLEDADYYSVERKATALASVSYAEGILDALRLLGLVDFEW
>A0A6A8AQI2|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MNELVFIGLGLYDEKDISLRGLEELKAADTVFAEFYTSLMHGLSIQKLEEMTGKAVNVVS
RRVLEEEEGQQLFEAAKKGKAVFLVQGDPMIATTHVDLRISAEKQGIKTRVIHGASVVSA
VRGISGLQNYKYGKAVTIPFSEQGFVSETPYNVIRENKKRGLHTMCYLDINAEEKKYLTI
KEALQTLLELEKLKKEQLVTSRTLVIGVARAGSYQPVVKAGYLEEVINYDFGAPPHTLVF
PGNLHFMEAEALIALAGAPQEVREMAE
>A0A662G395|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGLGLSGIKDISLKGFEILKSADYIFIELYTSIIPGFSIERFEKLINRKIRRVYRRDLED
LSGKEILSLAEKHRVVLLVPGDPFIATTHNSIRLMAIDRGISVKTIHASSIISAIYGSIG
LHCYKFGKIVTIVFPDERYGYFPETPYHVLHQNLSNNLHTLFLLDIRVDEKKYMTIGEAI
KILLELENKIGRKIISLKTIGIGVARIGSEDEKIVCNTLGKLLETNFGQPPYSLIIPGKL
HPMEIESLIKLAGADKRLFGGEYGGKNIA
>A0A1H8THA5|diphthine synthase|EC 2.1.1.98|Halorientalis persicus|TrEMBL
MLTFVGLGLYDERSITVAGREHLRAADRAFAEFYTSKLVGTSVPDLEAHHGVDIEVRDRA
GVEQDPDPILDAAVDGDAVFLTAGDPMISTTHVDLRLRAHDRGIDTRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFERAHGGSGVPDSVVETVDDNADRGLHTLVYLDIKAADDDYMTA
DTAADLLAAEYDDRLAVAVCQAGSADPTVVADALDALTDREFGPPLHLLVLPGDLHLLER
DALVELAGAPETLVADRTL
>A0A662GYH2|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGELVFVGLGLAGDGDLSLRAIEVLRRADFVYVELYTSLLPELDLSRLEGLVGKRVVRLR
RSDLEDGEEAILRRAERGTVAILVPGDPFVATTHVAVRLEAIKRGIRTRVIHAPSIVSAV
CGATGLQSYKFGRSVTVVYPEPALGYFPETPYDVLYDNLKRGLHTLLLLDLRVEEGKCMT
VREAIEVLSAIEDRKGLGIVGDDTLAVGLARVGCSTELVRGAPLPELARIDFGPPPHSLV
VPGHLHPMEAEALRLLAGVSAKAIERWERVVGELRGREGEEVHQGH
>A0A7J3TSR6|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLIGLGLDLKDISLKAVEALTKCSKVYLEIYTTALPYKKAALEKLIGKKVTIAVRETV
ENNSKEFVKEAKKKNVALLVYGDPLAATTHISLLQEAKKLKVPVKVLHNSSVFSAISETG
LQLYKFGKTTSIPKWQKDYKPTSFFRTIEENLSIGAHSLVLVDIGLNIEEALHELNEASQ
GKISNIIVCSRLGTDEQYIVYSTLKELLKNKKIQLQVKEPFCFIIPAPLHFTEAEFLELF
>A0A662URR1|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLVFIGLGLTPKHLTLEALEYINRVDKVVVDTYTSIVPGLDHEFLRDIVGDKELVLAKRS
DLEGRGIKRIVEEALKKNIAILVPGDPFIATTHDAIRVEAIRRGVNVVVVNGLSIYSLVP
SRTGLQAYRFGKTVTLVYPEVFKPYSVVEAVYDNLSRNLHTLILLDIRAEENKFMSIPEA
IDILLDLDNRSLLREAIGIGIARLGTSDETIIADKLEKLKHYEYPPPPHSIVVVAKPHPI
ELENLKLLCRLPENLYRKYVSSKHYP
>A0A662V4G6|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLILVGLGLYIDLLPLRSLAALARCDKVLIDAYTSAPREAVERVYEVLRAMGKRVSLAKR
EDLEGESIARIAEEARHSDVCIAVLGDPLIATTHSAICTEAASRGVKVVVIPAPSIHCAS
ITATGLMSYRFGRSVTLVTPKNGVFYEYPYDVIKENLSLNLHTLLLLEMDAEKGFFMDPC
EAGRLLMELEKRRGEGVLRSDTLVVVLSRVASPRH
>D5EAG9|diphthine synthase|EC 2.1.1.98|Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNANKVYVEFYTSRLMGADKEKMEDMYGREIHVLDRP
QVEQDPWWLEEAKEIDIAFLTGGDTMVSTTHVDIRLRAMEKGIETRLIHGSSIVSAICGL
TGLQNYRFGKAATIPHPYTSTRGNTIISETPYDTILRNRQMGLHTAVFLDIDMNKGYMTV
NQGIDLLLQVDEKRGENLIKGSIAVGIANAGSEKPIVKADFAENLKIYDFGSPLHIVAIP
ADLHFVEAESLVKLAGAPGSILEVEDKN
>A0A5E4P652|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MGLVLVGTGLWDETDISLRGLSALKKCARVYAEQYTCETRPGTLSRLEKLCGKSISLLAR
EEVEDGKRLLSEAAGRDVALVVAGDPMISTTHVSLKLDAFRKKIPFKVIHSSSILSAAIS
ESGLHTYKFGKPVTLPFWSENYKPTSTYDALQENRERGLHTILFLDLKGGKTMTAAEAFS
LLRKIEGERRKGAVSSGMKLLVLSRVGASDMKLSFGTLGKLEGKIRLLGKSPFMIIVPGK
LHFTEEDALALYAVK
>A0A7C2Q0J4|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MALYLVGLGLGSSGYLTRMAMEVIAKSDKAYLDTYTSFLEPELIEELRIILGSRLIEADR
RLLEEDVSRIVEEAGERDIAILVPGDPLIATTHISIIIEAARRGVKYHVIHGVSAHSALI
SASCLQAYKFGKIVTIPRSGVGVETCYRAILENMERGLHTLILLDTADGGLDIPSAIRML
MRVEDEFGMGLITPERLVICLARIGFGDEFRWAGSLAEALERNYPPPPHSIIFPGSLHFS
EAEALETLLGASPRVIEQHKPPWIIWQRLQRYIENVENALRGLELIDQSSEVKEVLDLVE
RYLDDSRRFLSGGRGLDSLAAISYAEGLLDCLRMLGRVRFSWSSRQG
>A0A1V4ZXE7|diphthine synthase|EC 2.1.1.98|Methanoregula sp. PtaU1.Bin051|TrEMBL
MLTFVGLGLYDDSDISVKGLACIAAADFVYLESYTSRLMGASVEDLERRYQKPVRLLFRK
DVELHADTILKAAADSNVAFLVAGDPMVATTHVDLRIRAEERGISTSIIHGASIASAVCG
LTGLQNYRFGKSCSLPFPQKNWFPITPMEVIVKNIAQNLHTLVYLDIREERFMTIPEAID
LLETLAGKMQAAIPLYVGVARAGSEMPVVAAGMADKIREIDFGPPLHIIAVPGELHEMER
RYLELFAGL
>A0A1F5CTQ0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon RBG_16_48_13|TrEMBL
MGELIFIGLGLHDESGVSLRGITDAKESEVAYIELYTNSMPELSLKRLEDLIGKRPQMLS
RDDLEERSNESILKEASRKRVALLVPGDPMIATTHITLRIAAERMGIKTRVVHGASIISA
AIGLSGLQNYKFGRSVTIPFPGNDKPSETPYEVLRENRSLGLHTLVFLDVRVEEGRSMRI
HEGLEILSSIESKRMEEVISNVMIVVGIARAGSDRPVVKAGRLRELLTFEFGDAPHILIF
PGRLHFMEEEALKVLGGYQK
>M0MRD2|diphthine synthase|EC 2.1.1.98|Halococcus saccharolyticus DSM 5350|TrEMBL
MLTFVGLGLYDERSITVEGRDALRDADRVFAEFYTSKLVGATVADLETYHDSEIEVRDRA
SVEQDSEPILDAAEGGEVAFVVAGDPMISTTHTDLRLRAHERDIETRVIHGTTAQAAASS
LTGLQNYRFGKATTIPFAYGDGDIPQSVLDTIDTNRERGLHTLCFLDIKAAEDRYMAAST
AAERLEPGLDDPLGVVVARAGSPDPIVAADRLSALAETDFGDPLHLLVIPGDLHHVERDA
LIGLAGAPEDLI
>A0A842V4B5|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALHLIGIGLSDEKDITVKGLEAVKKCRKVYLEVYTSVLQVRVRDLERFYGKKIIEADRD
LIENKADRILDDAKNDDTALLVIGDPMSATTHIDLMMRAKEKGIETVVVNNASVLNAVGM
TGLQLYKFGKTTSIPFPENVMSEAPYDSIKMNKANGLHTLCLLDLDPKKDRFMTVNDAMH
VLNGIEEKRKEGLFTGDTYVVGCARLGSQDFYIKAGRANELDEVHFGKPPFCLIVPGQMH
FMEEEAVKRFE
>A0A7J3UHY0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MVLYFIGIGLYDEKDVSLRGLEVIKKCDVVYLENYTSILSCNVKKLEKLYGKKIILSSRD
LVEKKAEETILKDALSKNVAFLVIGDPMSAT
>A0A843FQB4|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MTSGLIFVGLGLCGPDGMTVKAMNALKECDKIYAEFYTSFLIGTSVKDLEDAIGKKIKVL
HRMQVEEGEDIINDARTMKVGFVTAGDTMSATTHVDLMIQAKEEGIPTTLYNGISIFSAC
PTALGLQPYKFGRTVTLPFIEAGYQPQSPYDNILENKERGLHTMVLLDIHADEDRYMTGK
QAIEWLLEGERKWEKGLIKDDTLICVASKIGSSEQKLTAGYPKQLLEMDLGEPLFTLVIP
GNLHFMEAYSLVYFAGAPEEIIQDE
>A0A2R6D2U8|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_7_65_31|TrEMBL
MLTFVGLGLWDEDSITVEGQRALRAAEDVFAEFYTSRLMGTDPESLAAHHGVEIDVRDRA
GTEREPGPVLDAASDRDAVFLTAGDTMISTTHVDLRLRAHERGIETRVVHGTTAAAAAAS
LTGLQNYRFGKATTLPFPYAHGGEGVPASVCETLDANRERGLHTLVYLDIKRERGEYMTG
DVAAGLLAEGYEDVLGVVVCRAGSPEPRVEAGRLSDLAGQEFGGPLQLLVIPGKLHYIES
DALRALADAPESLTEPV
>A0A075G7K5|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_126_H01|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKTSKSSTVVLLSYGDPYVATTHIELRTRAKLENIETNTIHSASAITSMTGE
AGLQFYKVGRMVTIMNEKKSTITPYTAIFKNLTQGLHSIILLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVLNNDTFAIIASRIGFETQKIISGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSTRIKSTSVQMIEKYVPMVRKALEEIRPLYNDTKEFQEVFE
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKM
>A0A075GWU8|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_28_C05|TrEMBL
MLWFVGLGISGTRSIPIEVIKIIQEADFVYLESFTSPISKQHEVEIKNMVNGSFKIAKRW
LVEDGQEILKTSKSSTVVLLSYGDPYVATTHIELRTRAKLENIETNTIHSASAITSMTGE
AGLQFYKVGRMVTIMNEKKSTITPYTAIFKNLTQGLHSIILLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVLNNDTFAIIASRIGFETQKIISGKLSNLLKADFGEPPHSIIIPGKLHF
TESDAINVLTECLDKPSDNSTRIKSTSVQMIEKYVPMVRKALEEIRPLYSDTKEFQEVFE
NVELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKM
>A0A1V4V3R7|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaB.Bin039|TrEMBL
MLFFVGLGLFDELDISVRGLEVVRQADLVLAEFYTSRLMGSSAKRLSQLYGRPVTLLSRS
DVEESPGWLSEARDKDVAFLVGGDPMISTTHLDLRLRAEEMGIPTRVIHSSTIASAVPGL
TGLQNYRFGRSASIPFPYKARGKRIVPETPYMVFSENRRQNLHTLLYLDIQEDHFMTVNQ
GIECLLEVAVAGGETELGQALGVGVARAGSDGCMVRAGTLSQLVEIDFGPPLHILVMPGG
LHFMEARALQVLAKASPELVRRFEI
>A0A117SPM7|diphthine synthase|EC 2.1.1.98|Vulcanisaeta sp. OSP_8|TrEMBL
MGKRNPTLYLVGLGLSPGNLTIDALNIIRSVDKVFMETYTSKAPGELIKQIMGIRRDIVF
LSREDLEDRSGNAIMSELSKGRNAALLVIGDPMMATAHAAILVIAKRLGFEMRVINSVSI
VCAILSQLGLSPYKLGPIATITYPRMGILSMRAYEILNDNLRRGLHTILLLDIKDGNEFM
SAGEAIELLRKMEENGKLGIINNDLLVIYAARIGWENQSIVVSTISNVPSLGETPHTIII
PGLLNPVEIDYLIYVLNADKDLVLKHQRWVNKLMNGNWQK
>A0A7J4QIR8|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MPLIVTTGQDGISMTVDLPPTGLLLVGLGPGGRSGMTAAAIEAAQTADHRWYEAYTALWP
EQDVIDLEAHVGPIERVMRPDVEHPTEMFELARTSLVALLVVGDPLQATTHVDLQLRAED
AGVPCRVLHGLSITGMVTGAAGLSNYRFGRQTTLTYPHGAWIATSPLETIALNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHMMAERLAERPPEEGALSSLTSAALEGLDVGA
WTVVLCADVGTSDEAFVTTTVDGLPSEVGGRLNCLLVPAAIEGVEAAAIARWRRS
>A0A7J4T4I4|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MAAKHGLLLVGIGMGDIHSMTTSALNAVQNADLRILESYTAKWNDDDILKLKETIGEFEY
ALRPDIENPDKILAQCQENSVAIMVIGDPMQATTHVDLLLRAEELEIPYKVYHGISITNL
ATGISGLSNYRFGRPTTLTYAYGGWVATSPLEVISVNLQLNLHTLVLFDLDPTGLGTGNM
QPMLPIDARKVMYQMLEKWQEDSLQEIEEVVDSSFNFKQHSMKQLPENLSQLPVVVCTDL
GTTNQSLWRGILGSIEKAPVGNMHCMIIPSHLSEIEEKALNKWAKE
>A0A843ITG7|diphthine synthase|EC 2.1.1.98|Methanomicrobium sp|TrEMBL
EFYGKPVTLLNRDDVERFPGKILDAAAEGDAVFLTGGDPMVSTTHADIRIRAEERGIATR
IIHGASIQSAVCGLSGLQNYRFGKSCSVPYPERNWFPTTPLDTILSNFRQDLHTLVFLDI
KPDRHMSVPEGVELICRMAEKCGETAPPLYVGMARAGSESPSVFAGSAEDVMNHDYGAPL
HIIAVPASLHEMEREYLEIFAGLKRE
>A0A7J4PAG8|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MAELIFIGLGLWDEKDITLRGLEVARKCDRLYAEFYTSKLTGLKAERLEKLLGKSITVLS
RFQVEERADEILEQAEKTRVAFLVPGDPMTATTHLSLRIQAAEKGIETRVINGVSIRTAV
ASLLGLQSYKFGRTTTLVFPEPSFFPLSPYEAIKENKRRGLHTLVLLDIKAEAERYMCAN
EGIELLLKMESIKKENVLADDTLIAVVAQAGSPRPEIKVGGAKVLAREKFGKPLHSLVVP
GKLHFMEQKALEFYRVESNARSTL
>A0A662KV02|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSKGEILFIGLGLYDERDISIKGLEAAKTCDKLFAEFYTSRLSGADTSKLEKIIGKPIIV
LERNDVEKGEEILEMAGKGRVGFLTAGDPMAATTHVDLRLRAQERGIETRVIHGSSVFTA
VPGLLGLQHYKFGRSTTLVYPEDKYFPLSPYTVIKENKERGLHTLVLLDINREKGRYMTI
GEGIEILLKMEKETSYGMIDDNSLLCGVARAGSDNPTVRAGPARILKRIDFGPPLHTLVV
PGNLHFVEEKALEVFAGLKR
>A0A662M3W1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MKKGELVFIGLGLYDEKDISLKGVELVKKCDKIFAEFYTSVLTDDCIEKLEEMIGKKIEV
LNREEVEDGRVILEHAMDKKVAFLVGGDPLSATTHVDLRIRAKKQGVDTKIIHGSSIFTA
IPGLLGLQHYKFGRVTTLMFPHGDFFPKSPYEIIYENKSRGLHTLVLLDIDRENNRFMSA
NEGMKLLFDMEESLGKNLINDNLLVCVVARAGSDNPVVKAGRIKRLIREDFGSPLHTLVV
PGNLHFMEVEALISFAGLEKDELG
>A0A6V8F2N4|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSKGRLVFVGLGLYDEQDVSLKGLQELKQCDVVFAEFYTAKLGHFDIDAFEKLIGKKIEI
ISREETEKGDKIINAARNKNVVFLTAGDPMIATTHIDLRLRAIKQGSSTQIIHSGSIATA
VPGLLGLQNYKFGRTTTLAFTEKEYFPTSPYSVINNNKKMGLHTLVLLDIQAEKDQYMTA
NVGFELLLKMEEKLRKNLITADTIACVVARAGAPDVIVAANTIYVLRNQDFGPPLHTIVI
PGNLHFMEIESLELCAGLPLDARRKIPKL
>A0A8J8DCJ9|diphthine synthase|EC 2.1.1.98|Thermococcus sp. M39|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTRIEKIEELIGKPIRLLNR
EEVELHFERIVLSEAKNKDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
SITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTLLFLDIKADQGRYMTANE
AMEILLQVEEMKKQNVFTPETFVVVLARAGSLTPTLKAGYVKDMIKEDFGKQPHIMVVPG
RLHIVEKEYLVTFADAPEEILRRRDL
>A0A256YJQ8|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon ex4484_92|TrEMBL
MLIFVGLGLHDLQDLTFHGFSVLKKAKKIYMETYTNIMPDFSRERLETLIGQEIVEVSRE
FLESDKISQIIEEASKEDIVLLVPGDPFIATTHITVRIEAEKRGVKTMVVHAPSIISSAI
SECGLQIYKFGKIATIVYPEPELGFFPFSVYEVLKENLSRRLHTFFLLDLKVETGKLMTI
SDAIDVLFMMEEKLNEGVVTSDTLGVGLARVGSPNTILKAGSLAELKSYNFGPPPHSLII
PSILHPIEAEALIFLCNANKKLIEKWTRKIG
>A0A256Y5P2|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon ex4484_92|TrEMBL
MLIFVGLGLWNSKDISIKGYEEVKKADVVYIEFYTSQFHTSIESLSQFFGKDLEIIGRRE
LEEESEKIISKARENNVVILVPGDPMIATTHIALKLEAEKLGIKTKIINGISIINSVCSL
TGLHFYRFGKSGTISWIPSKYPLDILLDNLKIDAHTLFFLDLHPKPMEITSAIKILGEVS
KEILDLYAVGIARAGSNNPTVKCDKAKKLLKYDFGPTPHCIVFIAKTLHFIEFECLRKFA
DAPKELSEIVK
>A0A497GMT3|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLSFSGDTLMKEKNVKFKGKRMGELIFIGMGLHSEKSMSVEAVEVARKADVIYIERYTSI
MPGLSMKRLRELLKREDIIELHRKDLEDYSYKVIEEAMRKKVVILIPGDPFIATTHMALR
IEAERKGIKTRVIHGVSILTAIPGVTGLHAYKFGRTVTVVFPEDGRYSETPYDVTKENLK
CKLHTILLLDIRVEEGRIMTINDAINILRELERRRGEGIFTDERLIVGIARAGSPDVLVR
ANTLSEISNIDFGPPPHCIVVPGPLHFTEAEALMVLAKAPEDIVLNMVIR
>A0A533UFF3|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWLVGAGIYDTMEICSSIEILNKCDRIYLERFTSPISDNYITFLKSALPEKKIEIVKRW
FVEDGRQILDESKVMNVGLVSYGDPTIATTFSELRVRAIKNNIEAKVLHAASGITCLVGE
CGLQIYKIGKVVTMMEERQSAISVYNTIFNNLNQNCHTIVLAEYRLAEDNSVFFLKPNYI
MSRLLEVEKDIAYKIVSKDSFLIVASRIGTDSQNIVSGKIGSLLEQEYGAGPHSIIFPAK
FHFTEEEAIINLTKHLDGPADNTGSLKSVSAQMLEKYEPMIRKEIKQIRDIITSKKETKI
QLEILDNAEYYLDDAIQFLEQGKQELAILSVGYADGLVDSLRQILELV
>A0A7J3N042|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MIRFVGLGLSLEQLAIGAILRLLKCRKVYIDVYTNLWFPSIDELARVLKEHGIDVIMAYR
KDLEGYSISKIVREASEFDVCIATAGDPMIATTHVAIAVEAARNGVELEIFPSTSILNAA
MSLSCLQMYRFGKTVTVVKPKDGIVYEYPIHVIKINRSLGLHTLILLEVDIEKDYFMTPK
DAITVLLYIQRLLGEEVLSEDDVVVILKAIGSPKCEIKIRTIKEVLKEYFDKTVYTLIIP
AKKLHSIEEDCLRTIEKLKTYQTINVDTFRNIVKFMAI
>A0A7J4T8Q0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGLGLSDEKDISVKGLEAVERCGAVYLEHYTSVLNCAKQDLEKFYGKRVILATRA
LVEQDAEATILKDAAEKDTAFLVIGDPFCATTHVDLYLRARKAGIACRIIHNASVISAVG
VTGLQVYKFGKTTSIPFSNEQVDSPYEAMKENRKMGMHTLFLLDLDPIEGRYMTVGDAIR
YLLRAALRKGDGGFKDSTLCVGCARLGAKDPIIKAGSASQLLKADFGKPVHCLIVPGQLH
FVEEEALTLWKKENIQ
>A0A846PWX2|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGVWNEKDISLRGVEFCKQADSVYCELYTAHWGGDLEKLEKMIGKKIRKLKRKD
VEEESGKLLEEAKKKDVVLLVPGDPLIATTHVHLILEAKKANIPVEIVHSSSIYTTVART
GLQIYKFGKTGTIITPRKGYDSKGFYEIIRDNLSKGMHTLLLLDRDMGTRKGLEILERIE
NRKRRKILKGRRIVLCSRLSSEHERIVYGRMEDLRGKDLPEPGVIIIPGKLHFLEKEFLE
TLG
>A0A832VHE0|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotenuis sp|TrEMBL
MLFFIGLGIGGQESISEKTRKVISESDMVFFEQFTSPMSDDETKFLRELTEGEFKLAPRW
LVEDGKEILDAAKNGMVALVSYGDPYIATTHIELRVRAIQEGIKTDTIHASSAITSLVGE
CGFHFYKVGKTVTVMSGIPSATAYYAIFENLKLGNHTIVLLEWNQNKNFFLDPKEAIASL
LTQEREQVRKVFSGETYGIVASRIGQEDQKIIAAKFSTLSKLDFGRPPHTIIVPGAMHFT
ESDALKVLAECIDLPEDNTPKVEKISAQMMKKYIPMVRRALDKITPFYKDSKEFESVLEN
ADLYIKDAEKFYSQGQDELAILSIGYADGLVDALRIAKGIEPEL
>A0A842Y750|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFIGIGLFDEKDISVKGLEVIRQAEDVYAEFYTSVLTGTTVGKLESFYGCKINLLSRE
DVEQQPEWLQRAKTKNVIFLTGGDAMVSTTHVDLRMRAHDLGIETRIIHGSSIMSAVPGL
TGLQNYRFGKSATIPHPYSYKGKVIISHTPYDTIKSNLEANLHTLIFLDIDPEKGFMTIN
RGCELLMKMDEQLGEPGIADRLAVGVARAGSPQPAVKALPINELMDYDFGEPLHILVVPA
GLHFMEAEALVKLAGAPKSIL
>A0A7L4Q7E6|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLHFVGLGLYDERDISLKGLEAVRAADCIYAEFYTSRLMGTTLEKMEALYGRKIHPLSRQ
EVEVDPSWLEEGRNKDIVFLSGGDAMVSTTHLDLRLRAIKMGIETRVIHSSSIVTAVSGL
CGLQNYRFGRSTTIPFPYVSRGRRIIPQTPYQVLRENQERNLHTMLFLDIQMEPVERYMT
ANEGTALLMEMEANAGESGLMEAIAVGIARAGAPDASVKADLLPRLQGYSLGGPLHILII
PARLHFMEAEALRILADAPADAVQC
>A0A533WB16|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGTGISGYRGLSFDAVDTMKKCDLVYVERFTSALSDNDLHGLNSILGREVRSVQRW
FVEDGREILEAAKTKQVALVTYGDPLIATTHSELRSRAARNSIKTAVLHAASGLTSIMGE
TGLHVYKFGRMVTMMSEPQSAVSVYNTILENLLAGSHTLILTEYSHDESKEPFFLDPASL
FKMLLDVEHDQKHQIFSDNTFAVVASRVGMADQRITSGKVGSLAKIDFGIGPHSVIVTGS
LHFTEAEAIAALTVNIDGPADNSQTVKRISVQMVERYAPKAKQAVQQMRDVVRQDAGSKG
MFEVLDNAEYYIADAERFLRQAKFELAVLSIGYAEGLIDALRFQKGINPWEIRG
>A0A1Q7B546|diphthine synthase|EC 2.1.1.98|archaeon 13_2_20CM_2_52_21|TrEMBL
MSLAFIGLGLNDEKGMTLEGLEEARRADSVYGEFYTNIMPNLDLKRLEKEIGKKVEVLSR
SQLEDEGGEKLLRAASRERVAFLVPGDPLIATTHVSLRLSLAKMAIPSRVIHAPSIVSAV
CGATGLQSYKFGKSITVPRDQPLPKSVLDTISDNNDRGLHTLILLDVQVGKTSQMTIRDA
ITKITTADPRLETCLTVGVANLGSRDERVKASRMNALIREDFGNGPQSIIVVGRLHFMEA
EALELLCGASHEDLRELS
>A0A811TFI2|diphthine synthase|EC 2.1.1.98|Candidatus Argoarchaeum ethanivorans|TrEMBL
MLTFIGLGLSDEKDVSLRGLEAIRSADKVYLECYTSLFTGTNIKQLEKLYGKKVHLLERE
DVETNNWWLKDAIDQSIVFLTGGDAMVSTTHIDLRLRAKKLGIGTQIIHGASIISAVCGL
SGLQNYRFGKSATIPHPYTRKEKIIRSHTPYDTIKINQKNNLHTLIFLDIDKNIGCMSIR
EGIELLLQVEEEIGGEAISNCIGVGIARAGSFAPVVKADYLENLKHTDFGDPLHILCITA
NLHFIEAEALVAFADAPGNILNHHKDSLCQDSVSENHAH
>A0A6G3LPA0|diphthine synthase|EC 2.1.1.98|Acidilobus sp|TrEMBL
MLFIVGTGLGPQHVTDRAKSLIKKADVVIVEAYTSPNSGWLEDMAKALNKATVKATRDLL
EENVNTLIDMARSRDVVVLVAGDPLIATTHSSVVVEALTRGVKAKVIPGVSGPCAAMSLS
GLQFYRFGRKVTVPGPWRGTDATPVAYWLLGNLCLDLHSLILLDVDQEGGQLPPADGARE
LLKAFNELLSDQRADLGDLLVLAVSATDDDVNVTYSRLSEPEALRSVIPSTMIVPASLHP
VEQEFLKSVHGVPLSLIDLHLKLLRRIDPCSLYFSGRRKVMASP
>A0A7M3ZI80|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MENGSMTGFALIGMGPGKVESMTLEAVEVAKNADIRLYEAYTALWPEEELLKLEAMIGPI
ERIMRPAVERPEELFKQAQSQSIALLVVGDPMQATTHIDFQLRAEKAGLPCQVIHGISVT
TLVPGSTGLSDYKFGRSTTLTYPYGDWVVTSPLEVMLRNQAQGLHTLVLFDLDPTGAGTG
DQLPMQPKDAFASITKMADKLANSERDAVFEQQIESLTNSSCVLCSDLGTNDASMKTTTI
GNLGNIPGGRLNCLVFLANMSEMELEAVNRWR
>A0A1I4NZB9|diphthine synthase|EC 2.1.1.98|Methanolobus profundi|TrEMBL
MLTFIGLGLFDENDISLKGLEAIKNADMVFAEFYTSCLMGSNIERLEELYGKKVNVLSRE
DVEISPDWLAEAKDKNVVFLTGGDTMVSTTHVDLRLRAKDLGIDTKLIHGASIASAICGL
SGLQNYRFGKSSTIPHPYTSSRGVTVISETPYDTIKLNKEHNMHTTVFLDIDKDKGYMTV
NQALELLLKVEDKRGEGVMEDAIVVGIARAGSDVPVVKAGYAHTLKDEDLGEPLHILVVP
ASLHFIEAEALVKLAGAPESILEGLDD
>A0A099T100|diphthine synthase|EC 2.1.1.98|Methanococcoides methylutens|TrEMBL
MLDFVGLGLFDEKDISLKGLEKIHNADKVYVEFYTSILMGTDLEKMEELYQKKITVLSRE
DVEQHAEEWIADAKDMNVVFLTGGDTMVSTTHVDLRLRALDMGIETSLVHGASIASAICG
LSGLQNYRFGKAATVPHPYVTSRGSRVVSETPYDTIKMNMDNGLHTAVFLDIDKDKGYMT
VNEALEILLEVEGKRGEGVMTDRISVGIARAGSPSPVVKADYAQSLKSFDFGEPLHILII
PASLHFVEAEALVKLAGAPEAILEDVD
>A0A497SNQ6|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGIGLWDEKDISIKGLEAAKKCDKIFIEKYTSLWKGDLKSLGINAETVGREDLENN
INKILDIAKEKDVALLVPGDSLIATTHNSILLDAKKLGVKTKIIHSSSIFSAIGETGLQI
YKFGKVSTIAYYYSEAPYNLLEDNLKQDAHTLFLLDITKEKLMTCGEGLKILLDLENKFK
KKLISDETEVVVFCKAGSSEQILRYDKIKNLLNLNCFLCVIIIPGKLHFLEKEYLDSLRA
>A0A0F8DBS2|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 2.H.T.1A.3|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRRESVMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVNLAAGPEEIMEEME
>A0A7C4HH24|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYFISLGLSDEKDISLKGLEVARECELLFAEFYTTKLQTEKEKIEKLIGKKIEILSRKD
LEENFQNILNLAKSKKVGILVGGDAFVATTHLALKLEAMKQGIKTKVVHGSSIISAVAET
GLHIYKFGPCVTIPFPEKTKGKLPESVYEVIKMNKARGLHTLCLLDIEDERLMKINEGIK
ILLEIEEKRRENVLSLESEVVVFARAGSEDPLIAFGKVKDIIEKNFEDVPAVIIIPGLLH
FTEKEFLEFFKI
>A0A7J4G132|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
CDEIFLETYTSVWKGDLKKLNLKFKKIERVDLEENINKILTIAKEKKVAILIPGDPLIAT
THNSILEEAMKMKIKFEIIHNASILTAISETGLQIYKFGKIASISWYYSEYPYDVLKQNK
KIKAHTLFLLDTSPKPMSPKEGLKRLLEIEEKRKESLINKESFCIVASELGSKNKKILFG
KIKEMLDINFVPAVIIIPSDLHFSEKKFLSSLKNLKI
>A0A6G1YMQ6|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLRFIGLGINGHKTMSTHVLEILRNCNAIYLDKFTGFVSDDDLKELRSLAELHDFEINIL
PAERWFVEDGRDILEQARTSDLVLLTYGDPFIATTLIELYVRAVKNSIKVDVIHAASGIT
SLIGEAGLHIYKFGRIVTITSEPLSTVSVYNAIFENLLGRNHTLILTEYDNEHGKLFFLN
PNSAFNTLLQAEKDFRFKVFFEDTFAIVASRIGMPDQKIVSGTVRSLNGIDFGQGPHSII
ITGALHFTEVEALMTLTHNLNEPLDNTANMQNLSAGMIARYAPKAREALSKLKRISSTDK
GISGNKINMEILANAECYIDDAERFLRQGKPELAVLSIGYAEGLIDAMRVNKGIDP
>A0A7L4P1U7|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
MLYLVGLGLYDEKDVSINGLEAIKSADEVYAEFYTARLFGGDLKSLETLSGVQINILSRE
EVEEDNVPLKQALNKDVAFLTAGDPLMATTHTDILMEARKKGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEDNYFPHSPYQVIKDNLEMGLHTLVLLDIQAHRDYYMTANEGL
EYLMRVENDLKEGLFTDDSLAVVIARAGSENPLVRADEVGKLLGEDFGGPLHCIIIPGDL
HFLEAEGLVILGGAPEKLFKD
>A0A4P2VAY0|diphthine synthase|EC 2.1.1.98|Conexivisphaera calida|TrEMBL
MLLVGMGVHGAQGLPVGAVEELRRCDRVLLDSYTTPIDNIRALKELRALLGTEVKEAGRD
ELEDVQGLLRSASAGCLGIVIPGDVFVATTHDAIRQEAARSGIEVRIWHSSSIVSSALSR
VGLHIYKLGFIGTLVAGPPQTAYRAYFGVTGALRNSQHSILLMQHDPASGEGIDVGNGLR
ALVEAESSWRLGSFGPDRIIVIASRLFSESESVRVLRLSDALDMDFGEHPHTIIVPGRLH
YTEAESMRAVLGVPQELTDAMGIVPRSLAARLAGTAIEKSRAALPKFRSSIPGSPGVNSV
LENVESYLSDAERFLGEGNVELALAEAGYAEGLLDSLRLLGYAGIEW
>A0A836QF54|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopelagicus sp|TrEMBL
MLWFVGLGVSGPDSIPKEVGKIIQKADLVYLESFTSPIYKEHEEDIKNLVNGNFKIAKRW
LVEDGQEILKAAKNSTVILLSYGDPYIATTHIELRTRAKLENIETKTAHAASVITSMIGE
VGLQFYKVGRIVTIMSEKKSITTPYKIIFKNLIEGIHSVILLEYNQDENFFLDPKDAILS
LLDAEKEQKRNVVNENTFAVVVSRIGLKTQKITSGKFTNLLKTNFGEPPHSIIITGKLHF
TESDAISVLTECLDKPLDNSSRIKSVSIQMIEKYVPLVREALEEIKPFYNDSKEFCEILQ
NAELYINDAEDFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>A0A256ZNM6|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon ex4484_2|TrEMBL
MLYLIGLGIHDEGDVSIKAIETLKKVNVVYAELYTSFFNGDLSVIEKWAGKKINVLGRYD
LEEDIDGNVLSNPHKDVALLVCGDPLIATTHADVILRARKKGVEVKIIHSSSIYSAVAET
GLQIYKFGKTTTLPFPQGDYFPTSPYDVIKNNHDLGLHSLVLLDVKSEETRFMTVNEGLR
LLLRMEDEKKKRLIVDDLSLVGIARLGGDSLIRVGTLEELLDLDFGRPPHSLVVPGELHF
TEKDMLDMFRLD
>A0A7C4H329|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MIRFVGLGLSLEQLAIGAIFRLLKCRKVYIDIYTNLWFPSVEELARILKEHGIDVVMACR
EDLEGYGISKIVKEASESDVCIATAGDPMIATTHIAIAVEAARNGVELEIFPSTSILNTA
ISLSCLQMYRFGKTVTVVRPKNGVVYEYPIHVIKINRSLGLHTLILLEIDIEKDYFMTPK
DAINILLDTQRLLGERVLGEDDIVVILKALGSPKGEIKVRTIKEVLKEYFDKTVYTLIIP
AKNLHPVEEDCLKIIEKLKIHHTMDMDIFKNIVKFMAI
>A0A2R6HXX4|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_5_70_17|TrEMBL
MLTFVGLGLYDESSITVEGRDALRAADRVFAEFYTSRLAGTTVDDLAAHHGVDIEVRDRA
GVERDPEPILRAAAEGDAAFLTAGDTMISTTHVDLRLRAAEREIETRVLHGTTAETAAAS
LTGLQNYRFGKATTLPFPYAHGAEGVPGSVRETLTANRERGLHTLVYLDIKQERGEYMTA
DRGADLLATHWDGAALGVAVCRAGSPDPLVAADRLDALADRALGDPLHLLVVPGDLHALE
ADALVELGGAPEEVLPDPV
>T1AW14|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
SSLQVRALEALGKCTSIYVETYTSGSRENLVDTLRKALGKEVTLLPREKVEQSRMILNSA
RTSDTAFLVQGDALTATTHNQVRIDSMAEGIDVIVLENSSIITAIIGYLGLQIYKLGQVV
SLPFVTERFFPRSPYDKILGNMERGLHTMLLLDITETGYMSVPEACSILERMNERFGNRL
DLDAMKIAVVHAYGTGSLAVRYGKMADVCKAEYTQNPSTIVIPGKLDFYEKQFISHFAIG
>M0DTU0|diphthine synthase|EC 2.1.1.98|Halorubrum tebenquichense DSM 14210|TrEMBL
MLTFIGLGLYDERSITVEGREALRESDRAFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVERDPEPILDAAESEDVAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSASSS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETVEANRERGLHTVVYLDIKVGTGPTGAD
PDHEEYMTADVAAGMLADAWEDALGVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPGSLVEE
>A0A832L7Q7|diphthine synthase|EC 2.1.1.98|Methanosarcina sp|TrEMBL
MLTFIGLGLFDECDISLKGLESIREADLVYAEFYTSCLMGTNLEKMEKLYGKKVFLLSRE
DVEQYPDWLNEARDRKLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRVISETPYDIIKQNLELGLHTLVFLDIDQEKGYMTV
NTALELLLEVEEKRGEGVMRGTAAVGIARAGSEKPVVKADYVENLKDFDFGKTLHILVIP
GKLHFLEAEALVRLAGGQIGFMSEVE
>A0A2H9PHX2|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon CG_4_10_14_0_8_um_filter_37_24|TrEMBL
MLNLMGLGLSDEKGLTLEGLETLKKSDKVYIELYTSKWFGSIENLEKMTGKKIMQLKRPD
LEENLEKILKEAKNQTISILILGDPLVATTHTALLIEAKKLGIKTRVIHNASIYSAAGET
GLHLYKFGATVTIPFLEKMNNQFPESLSKIIRDNKGRDLHTLCLLDLISEKEKYMTPSEG
MEVLLKSDDITQEDEIVIFGRAGSEEPLIAYGKIKNLIDKDFGNPPFVLIILGKLHFTEK
EYLEYHRAD
>A0A162FFC4|diphthine synthase|EC 2.1.1.98|Methanobrevibacter curvatus|TrEMBL
MLYFVGLGLFDIKDISIKGLDTLKKADKIYAEFFTSKLFGSSIEAIEELIAKKIIILNRQ
EVEEDNLFFNDADKLNVALITGGDPLIATTHTDFLVEAKNKGIDYEVIHGSSILSAAPGL
SGLQAYKFGKVTTIPFPDENFFPKSPYLNIISNLKNNAHTLVLLDIQAHKNRYMTINQGL
KYLMKINEDLKNDLNKNLSSDLNDGLSSDLDESNQINSKNNNEAILNEESLVIGIARAGS
PDVLIKAGKIKDLIDFDFGGPLHCLVIPSKLHIVEGEYLVSIAGANKDILDDL
>A0A847TW38|diphthine synthase|EC 2.1.1.98|Halomicrobium mukohataei|TrEMBL
MLTFVGLGLYDERSITVEGKEALQTATDIYAEFYTSKLIGTTIQKLEYYHDIDVEVLDRA
AVEQTPDELLDAAEDGDVAFVTAGDTMVSTTHVDLRLRAEERGIHTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVETITANQERGLHTLVYLDIKVDDPHWEGE
QEFMTADHAAGLLADHLDTLGVVVARAGSANPVVEADSLDALGDGDYGGPLHLLVVPADL
HEMERDALTTLADAPLDD
>A0A1G7LSD0|diphthine synthase|EC 2.1.1.98|Halorientalis regularis|TrEMBL
MLTFVGLGLYDERSITVAGQERLRDADRAFAEFYTSNLVGTTIPELEAHHGLDIEVRDRA
GVEQDPDPILDAAAEGDAVFLTAGDPMISTTHVDLRLRAHDRGIETDVVHGTTAQTAASS
LTGLQNYRFGKATTLPFERAHGGDGVPDSLVETVADNADRGLHTLVYLDIKAADGDYMTA
DTAADLLATEYDDRLAVAVCQAGSPDPTVVADDLAALADRDFGPPLHLLVLPGDLHLLER
DALVELAGAPETLVEARTI
>A0A831ZAM8|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MAGILGFVGLGLGKDDITLKGLDFLRKCSTIYFDIYTSLSSEINQAYLEELTGKTVMPVN
REFIETEKRKEIYQRCLKGENVAIACIGNPFFATTHVALRIEAEKLGIRTAVFNSFSILD
GILSATGLEPYKLGKIVTIVYPESEYGYFSTTPYKVLRDNLARGLHTILLLDLKLEKRLA
MTIPEAIELLASMEKQFNEGVITEATIGIGLARVGTNTQVVKAGKLRELEKTDFGEPPHT
LVIPGTLDPVEREALKILGNIEDEAITEWLQRLKEKPKNT
>A0A832JRC2|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGVGLYGLRDITLGVLEYLLRADRVFLELYTSIVPGFKVEDLERLIGRSIALVRRG
DLEGPWLQELIRMAERELIVLLTPGDPFIATTHVSLRLEAAKRGVDVKVLPSPSVINVVS
ASTGLDFYKFCRPVTIVRPSPSYFPSTPYHVLRKNLARGLHTLFLLDLDVEQGYAMTASE
AVDVLLELERREGGNILGDDALLVAVARATSHDEVVAAFTPAQRPDLGPPPHLLIVPGLL
NAVEAEALQTLAGAPADLVKRWCSKVRALIADACC
>A0A2R6HQE9|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_4_62_28|TrEMBL
MLTFVGLGLYDEQSITIEGREALQAASTVFAEFYTSRLVGATASELASYHDIDLQVLDRA
TVERDPGEILDAAEDDDAVFVTAGDTMVSTTHVDLRLRAERRGIETRVIHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGEGVPDSVVETITDNRSRGLHTLVYLDIKIDDPHWDGT
ETFMTADHAAGHLATEFPDALGVAVARAGSPEPVVEADTLDALAADGFGDPLHLLVVPGD
LHEMERDALRHLAGAPISR
>A0A075I8N4|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote SAT1000_27_D07|TrEMBL
MTERARGVARDCSKRYLEGYTAVLPPKEEGRLESVVGPWEKLMRDEVEGAEELLASARGE
SVALLVVGDPMQATTHIDLEDRCDEQGIGFHVIPGLSATALAVSLSGMQSYRFGRQVTLP
FATSDYLPTSPLKMLCNNFENGLHSLVLLDLDPTGMGLEQPRPMSPAEAVGLLEKMEERL
VNEEDGRRGRLELPVKQWNGILLSDLGTEEERVLSGHLGDLSGQKGGMVHAFILPAEFSG
MEKDAFERRRTT
>A0A8E7AWM5|diphthine synthase|EC 2.1.1.98|Methanospirillum sp. J.3.6.1-F.2.7.3|TrEMBL
MLIFVGLGLYDLDDISIKGLRAIEQADTIFLESYTSILMGANPDLMRELYKKPIIILKRQ
DVEQYPEPILTAAKSGNVVFLTGGDPMVSTTHADLRIRAKEQDIQTKIIHGSSIVSAVCG
LSGLQNYRFGKSCSIPYPAKNWFPKTPLDTILSNIQQNLHTTVYLDIQENRFMTVHEGID
LLEKLMEGSSDTIPLYVGIARAGSDNPIVAAGSSTQLKHIDFGPPLHILVIPGTLHEIEE
EYLKIFAGYEP
>A0A895AUL2|diphthine synthase|EC 2.1.1.98|Halobacterium sp. BOL4-2|TrEMBL
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHVERDALRELAGAPADAL
>A0A2J6WSP9|diphthine synthase|EC 2.1.1.98|Aciduliprofundum sp|TrEMBL
MLRLVGIGLNPKKHITQEALEKIRNSDEVYLELYTSRIVDMSLEELENFLNRKIILLDRK
TVESNFLVERSRNLDVSLLVPGDPIIATTHIGLVILSIENGIKYEIINGISVQCVVPSIL
GLQNYKFGRSISIPFPEYDYYPESVYNFLLENRRLGLHTLVYLDLREGLEMSAIMGLDIL
LKMEDIHRKNALDRNTVVAVISRAGSDRQRATADTVERIKTRDLGPTPHIMVIAGTLHYM
EIEALRKLASFPDDQNVNL
>A0A2D3C7S9|diphthine synthase|EC 2.1.1.98|Methanohalophilus portucalensis|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNADKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKDIDIAFLTGGDTMVSTTHVDIRLRAMEMGIETRLIHGSSIVSAICGL
TGLQNYRFGKAATIPHPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMNKGYMTV
NQGIELLLKIDEKRGENLIKGSIAVGIANAGSEKPIVKADFAENLESYDFGSPLHIVAIP
ADLHFVEAESLVKLADAPESILEEGEEN
>A0A2R6LDL1|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_5_70_135|TrEMBL
MLAFVGLGLYDERSITVEGRRTVERADRVFAELYTTRLAGATVADLETFHDVSVERRSRE
GIERDPGPVLAAAAGGTAVLLVGGDPMVSTTHVDLRLRAHEREIDTRIVHGTSAATAAAG
LTGLQNYRFGPATTLPFPDAHGVDGVPGSVHETLAANRDRGLHTLTYLDVKAADDRYMTA
DRAADLLLAAWHERSWGDGSIDRPTGEAGPLAVAVARAGAERPTVVADRLAGLADGDYDY
GDPPHLLVLPGDLHHVEREALSAFAGASVSLRR
>A0A7J2YEP8|diphthine synthase|EC 2.1.1.98|Nitrososphaerales archaeon|TrEMBL
MLLLVGLGIHGYAGLGAKALDSLLGIKNIYVEKYTSPMPESEIDGLKRILNKDVKIVPRW
FVEDGREILQIAKNDDAALIVYGDPMIATTHVELRVRAEKNGVKTKVLHGSSSITSIIGE
CGLHMYKIGKIVTLTSEMQSVPTVYYTVYSNLLSGSHTLILLEYNQEKNLFLKPNDALNM
LLEAEKDKKHGVFSEDTFAAVASRIGSDDQKIISGKIKSLIKTDFGEPPHSIVITGNLHF
TEIDALNVLTESLDEPVDNSKNITRIADQMIAKYVPKARKALEQARSLVNNEKNYGDIFD
NAEYYIGDAERFLQQGKPELAILSIGYAEGLIDAIRFLKGVNIWE
>A0A8J8F1P9|diphthine synthase|EC 2.1.1.98|Natronococcus sp. JC468|TrEMBL
MLTFIGLGLYDERSITVEGSEALRQADQAYAEFYTSELLGTTVEELEDAHDVSIEVRDRA
GVEQEPEDMLAAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIGTRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDANRADGLHTVVYLDIKAERGEYMTA
DTGAELLADVYPELVGVVVARAGSPDPLVAAGRMRELAERSFGDPLHLLVVPGECHLLEA
DALVELAGAEEDALDVA
>A0A2I0NRZ7|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon HGW-Methanomicrobiales-6|TrEMBL
MLTFVGLGLYDLGDISVKGLECVKCADAVFLEAYTSRLMGTNVAEMEAFFEKEIRVLARE
DVEQNPREILDCAANGRVVVLTGGDPMVSTTHADLRLRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPVETITANLALNLHTLVYLDIQKDRYMRIPEAIT
ILEEMAQKRGIEPPDLYVGIARAGSDHPAVAAGTGAKLKETDFGPPLHILAVPAELHPME
REYLEMFAGL
>A0A7C2SQG1|diphthine synthase|EC 2.1.1.98|Archaeoglobus fulgidus|TrEMBL
MLTFIGLGLWDVKSISVKGXEAVKEADEVYVEFYTSKLSSSIDEMEEFFGREIVELERSD
LEENSQRLIERAXEKNVVLLVPGDPMVATTHSALRLEAERRGVRTRIIHGASIISAVCGL
TGLHNYRFGKSATVSWHRSETPVRVVNANRSIDAHTLLFLDLHPEPMKIMEAVDLLISVD
DTLKDFYAVGLARAGGEDPVVKCDKLEALKDIDFGEPLHVMVILARTLHFMEFECLREFA
DAPPELERLVA
>A0A662NQN1|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MVATTHSELRIRAKRMGIKSYVIHAPSIYSAIAVTGLHIYKFGKSATVAYPEGNWFPTSY
YDVIKENKERGLHTLLFLDIKADRGKYMTANEAMELLLKIEDMKKQNVFTEDTLVVVLAR
AGSLEPTLKAGFVKDMIRRDFGKQPHVLIVPGKLHIVEAEYLVEIAGAPEEVLKLAR
>A0A847TJN8|diphthine synthase|EC 2.1.1.98|Haloarcula rubripromontorii|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDLETLADALETSIELRDRA
GIEQDPEPILEAAEREHVVFCTAGDTMVSTTHTDLRLRAEDRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEANQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTARQAAAMLSEPFPDTLAVVVARAGSPEPLVVADTLDELATQTFGDPLHLLVIPG
SLHPLEADALESLAGAALE
>A0A832LXN8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLKFIGLGLYDEKGLSILGLEEAKNSDVVFAEFYTSFMPGLSLNRLKNLIGKPIQILSRK
DVEEKGEEIILKVAKEKDVAFLTPGDPMNATTHIALRIKAEKMGIKTKLIHAASIFSAIA
GVTGLQSYKFGRSVSIPIANKFPISETPYNVIKINKDLGLHTLVLLDLDVEAGVYLTVPE
ALKQLLIVEEYRKENVINLDSFIIVAARLGGATMEVKGLLIKDALNQNFGKPPFSIVFPG
KLHFMEAEALQVLTGAKKEFLKGNL
>A0A7J3FB06|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVGELVFVGLGLYDHLDISLRGLREVKDAAYVFAEFYTSLMPGFTLEDFRKITGKDVTVV
SRRNLEDESGRMILEKARDAKVVLLVPGDPLIATTHIALRLRAEREGIKTRVVHGASIIS
AVIGLSGLQNYRFGKSVTIPFFENGCISRTPYLVVAENKARDLHTLCFLDVRAEENRYMT
IRDALEILLTLEEKIRQGVLSENKLAVGIARAGSEDVRVKADSIKDLMSFNFGGPPHSLI
LPAEKLHFMEAEALIALANAPRWVMEMSK
>A0A497MX07|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLLVFVGLGLHDEKGLTLRGLELARRADAVFLELYTNPMPNLRLEQLRRLVGRPIKLVS
RKMMEEEEGKQILKEAEKGLTVLLVPGDPFIATTHIDLRIRAEKMGIKTSVVHGPSIISA
AISLSGLQNYRFGRTVTIPYPEMESYPETPLRVILENRGRDLHTLCLLDVKAEERRYMTV
RDTLEVLLRAEEKAKVGAVGLNTLVVAVASAGSPNPIVRAGSVGEIMGEDLGQPPHTLIF
PASLHFMEAEALITLAGAPEWVRGWLK
>A0A419KQA4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRRGLKLISIGLADEYDLSLRAVEEARSCDRLYVELYTTKLSTSKERLEAILGRSLREAY
RRDLEGERPRILEEASQSLIGLLIGGDCLTATTHISLLLEARRRGLPTWVIHGSSILTAI
AETGLSLYKFGKVVTLPLPERGPPDTVLEALEGNLSLGLHTLILLDLDAERGRWLSIGEG
IRLLLNADRPDIFNDETPLIGVARLGWRNPLIRGGRASELLNIDFGEPPQALIVPGRLHF
VEEEGLRLLANLPGEALKGWRPRSETELLVERYMKSCRRVIEKLESSPLREEAQRILDYA
SRYLSDAEYYANEGRWPTALAAVSYCEGLLDALRLLGLAEFEW
>A0A7C4M548|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELIFIGLGLHSCLDISLRGIEEIKRAEHVFAEFYTSLMPGFRIEDFRRITGKDMMVVS
RKNIEEEGGEIILKRALDGRVAFLVPGDPMIATTHIALRIKAEKMGVKTRIIHGASILSA
AIGLSGLQNYRFGKSVTIPFPEGSIISQTPYTVAFENKLRNLHTLCFLDIRAEETKYMSI
REALEILMRLEEINKLGLLKEDSLAVGVARAGSENPIVKADAIKNLMKFDFGGPPHTLII
PADKLHFMEAEALIVLAGAPKWVMGMVG
>A0A497KU93|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKLSSLILLSVKNFLFERMFLGSLIFVGLGLYNEYGISLRGLEKAKKAQKVYVELYTNPM
PALSLENLEKLIGKPVVELKREDVEEKPEKSILEDAKKMDVVFLVPGDPMIATTHISLRL
EAQKAGIETEVLNGVSIYSAAPSTIGLQIYKFGKTVTIPFPTSTYKPQTPYDVIKENMER
GLHTLVLLDVDVEKKRWMTIREGLEYLLKIEAERREEVVTSKKLVIGLGGIGSPNPMVKG
DSVERLVKYEFNVFPQTLIFPGKLHFMEVETLKVFAGVPEEVLQSHEHG
>A0A497PDY8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKISNNLFFGPIDNLNSQNFFQILIIRLIFCYDPLLKENNLTNLTLIGLGLHDEKGISLQ
GLEKAKRATYVFAEFYTNYMPAIKISNLEKLIGKQVKILSRKEVEDHAQEKILVHAKKYP
CAFLTPGDPNIATTHIDLRLRAEKEGIRTSIIHSASISSAIAGATGLQNYKFGRTVTIPF
KSTSISEIPYENIFENKLRGLHTLALLDINSESHLFMSIPEGLTIIIEMEEKLRKRCTTK
NMLAIGVARLG
>A0A497KWS1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGRGLKLISIGLADEYDLSLRAVEEARSCDKLYVELYTTRLSTSRERLEEVLQRPLTELS
RRDLEGEKPRILDEASRSLVGLLIGGDCLAATTHVSLLLEAKRRGIPTWVIHGSSIFTAI
AETGLSLYKFGRIVTLPLPERGPPDTVLEALEGNLSLGLHTLILLDLDVERDRWLSVSEG
VRLLLEADRPEVFNEETPAIGVARLGWSNPLIRGGRAMELLDVDFGDPPQALIIPGRLHF
MEEEGLRLLADCPGEALKGWRPRGEPEHLVERYMKSCRRVMEKLRDKPLSEGARRILDYA
ARYLSDAEYYAGEGRWPTALAAISYCEGLLDALRLLGLAEFEW
>A0A537F7K8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
VQLEDEGGKQIVEAVERGRVAFLVPGDPMIATTHISIRLELAKKGVPSRIIHGPSITSAV
CGATGLQSYKFGKSVTLPHESGVPASVLDTLHDNGKRGLHTLMLLDVRPEQSKQLTIGEA
AAKLVVADPRLQRSLGVGVARIGSDGQFVLSRRLETLQHQEFGKVPHSLVVPGKLHFMEA
ESLKAFCGASDEDLESLK
>A0A0E3QBX3|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. Kolksee|TrEMBL
MPGSAQTKSFKLAGLLKRAMLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSVLMGT
NLEKMEKLYGKKVFLLSREDVEQHPDWLSKAKDSNLCFLTGGDTMVSTTHVDLRLRAEKL
GIETHLVHGASIASAVSGLAGLQNYRFGKSASIPHPYESRRGTRIISETPYDIIKQNLEL
GLHTLVFLDIDKEKGYMTVNTALELLLEVEEKRGEGIMRGAIAVGIARAGSEKPVVKADY
AEKLKDFDFGKPLHILVIPGKLHFLEAEALVKLAGGPAGFMKEVE
>A0A8J8A3Z6|diphthine synthase|EC 2.1.1.98|Thermococcus sp. LS1|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEEIIGKPIRRLSR
EEVELQFERIVLSEAKDKDVAFLTAGDPMVATTHSDLRIRAKEMGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGEGVFTPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPRKILEEV
>L9Z8C2|diphthine synthase|EC 2.1.1.98|Natrinema gari JCM 14663|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRVYAEFYTSKLIGTTIEDLESYHDIEIETRDRA
GVEQHPDDMLEAAESENVAFLTAGDTMISTTHVDLRLRAHDRGIETRVINGVTAQTATSA
LTGLQNYRFGPATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKAERGEFMTA
DVGAELLATDYPDLVGVVVARAGSPEPLVEAGTMSELATREFGDPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A6A2FH51|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedens sp|TrEMBL
MLTFIGLGLYDEKDITVKGFDAVKKADAVYAEFYTSNLIGTSIEKIEKFYGKKLIILSRE
EVELEPVWLSRAIKENVVFLSGGDAMVATTHIDLRLRAKDLGIESAIIHAPSIYSAVSGL
SGLQNYRFGKSTTIPFPYTRNEKTIISEAPYDTIKMNRKNDLHTIVFLDIDREKGFMDIR
KAVSLLLEMEERRGEGVLVNALAIGIARAGSPSPVVHSDYLEKIKEYDFGGPLHTLLIPA
SLHFIEAEALVKLCGAPPDILI
>R7PY64|diphthine synthase|EC 2.1.1.98|Methanoculleus sp. CAG:1088|TrEMBL
MTSELVFVGLGLSGVDGMTVKALNALKECDKIYAEFYTSNLIGTEVSDLAEFIGKEIHVV
YRSEVEEGHDIIEDAKTMRVAFVTAGDTMLATTHVDLRIQAVMEGIPVRVFNGISIFSAC
PTCLGLQPYKFGRTVTLPFLERNYQPKSPYDHIMENKKRGLHTMILLDIRAEELRYMTAK
DAIEWLLAGEEKWGEGLITDKTLLCVVSHAGAEDEKVVAGYPKDLLQMDLGAPLQTLVLP
GELHFMEAEALVDFAGAPEEIIQDDE
>A0A7K4NSC9|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKTSKSSTVVLLSYGDPYVATTHIELRTRAKLENIETNTIHSASAITSMVGE
AGLQFYKVGRMVTIMNEKKSTITPYTAIFKNLTQGLHSIILLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVLNNDTFAIIASRIGFETQKIISGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSTRIKSTSVQMIEKYVPMVRKALEEIRPLYNDSKEFQEVFE
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKM
>A0A075HRR3|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_85_C11|TrEMBL
MLWFVGLGISGTQSIPIEVVKIIQKADFVYLESFTSPIYKQQEEEIKNMVNGSFKIAKRW
LVEDGQEILKASKSSTVVLLSYGDPYVATTHIELRTRAKLEKIETNTIHSASAITSMIGE
AGLQFYKVGRIVTIMNEKKSIITPYTAIFKNLIQGLHSVILLEYNQDENYFLNPKDAISS
LLDVEKEQKRNVVNNDTFAIVASRIGFETQKITSGKFSNLLKVDFGELPHSIIITGKLHF
TESDAINVLTECLDKPSDNSSRIKSTSIQMIEKYVPMVREALEEVKPFYNNAKEFQEILQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>T0LVD3|diphthine synthase|EC 2.1.1.98|Ferroplasma sp. Type II|TrEMBL
MLNIMGLGLRGVKSLTLEEADAIRESEIVYFETYTSISPQDTINSIPSLTKGIVKPADRK
LVETDKEIINEAKKKNVTLLVTGDALSATTHNELRMEAKKSGIEVRIFENASIITAFISR
TGLFNYKFGNIVSMPFVYENFFPVSVYERIYTNYSNSMHTLLLLDLKDGKTMHVCEALSI
LLKMEEKKGKGLINSGIIVIAGIGIASENERIIYGTLEKIMENNPQGSPASIIIPSRMND
VENEFLNAFAMKI
>A0A1J4USZ1|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon CG1_02_49_24|TrEMBL
MLLLAGLGLDFGISDEKLKQIEKCKTIFLENYTNLVSKGEMGKLKTIFQKTKKGIIVLGR
EQVENEKIILDAMANGDVALLVSGDPLIATTHHSLVLSAKKANHKTKIIHSSSIISAAIS
ESMLQVYKFGKIVTIPFPRNGFDPTSPYENIGFNLKNGLHTLLLLDIDSEKGAMPPNEAF
EILEGWEKKLKKKVITEKTKLLVLSSIGKDDSKVVYGTIVQLRKLKFNNPPHCLILPAKL
HFMEEELLAFFCLNG
>U1N198|diphthine synthase|EC 2.1.1.98|Haloquadratum walsbyi J07HQW2|TrEMBL
MLTFIGLGLYDERSISIAGRDALQAADYVAAEFYTSYLVDATISELETTHNITIDIRDRE
GVEQHPEDILTKAQSEDVAFLTAGDTMISTTHTDLRLRAIDRGIDTRIIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPYAHGADGVPTSVTDSIVANRKRGLHTIVYLDIKAEREEYLRA
SDAAAMLASDFQDVLAVVVARAGSPDPTVRANRLSELAENDFGDPLHLLVIPGELHHLEI
EALDALADAPADLLDTTEPR
>A0A8D6PTR8|diphthine synthase|EC 2.1.1.98|Methanocaldococcus sp. SG7|TrEMBL
MIVFAGLGLYDENDMTLKTLKFAKKVDKIYAEFYTSILTGTTIEKIEEVLGKKIHVLSRK
DVEYEGYKIIEEAKDKDIMFLTAGDPMVATTHIDLAIEAKKRGIEVLIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIEENEKRFMTANE
GLKILLELENRKKENVLSEETKVVVVARLGSLKPKLVYGKIKDLINYDFGKPLHSIIIPG
KLHFMEEEALKYLCENI
>A0A2I0N6D1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon HGW-Thermoplasmata-1|TrEMBL
MGELIFVGLGLYDERDITLKGLDEIRSSDRVFAEFYTAHLSGSSIGRLEELFGKKITALD
RAGVEQMEEELLAAAENGKVAFITAGDSMTATTHVDLRMRAHERGIITKVVHGVSIATAA
AGLLGLQSYKFGRATTLVFPEKNYFPISPYDVIRSNLAQGLHTLVLLDIRADEGRYMTAS
EGAKIIMRMAEETGDGGVDGKTVACGIARAGSGSPMIVAGPLSEIAKTDFGPPLHCLVIP
GKMHFMEEGALRVLCGMR
>A0A662TS42|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLLLVGLGLGDPDGITLRGLNLAKQADIVILDAYTSVLPEAYIKQISALLDRSITIGSRY
DLEDRAADIIEQARTHNVCILVPGDPLIATTHLSLIQMALQKGIPVDVVNGVSIHTAAIS
LSGLHIYKFGPTVTIPLEAMERKIRSPADRILENLKRGLHTLTLLEYDAKRAEGVTVNYA
ARYIHEHLPQVYSRDQPSVAVIRAGFPDAVVVAAPIYELEKGEFPPAPHTLIVTGDLHFT
EEEWLRLLQKAPPYLGRASRFHRKSR
>A0A7L4RT72|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MSLLLIGMGIWGEKDISLRGLEELKGCDVVFAEQYTGSREPNSLKRLEKLAGKKIILIGR
EEVEGEEKILKAALSKRVALLVPGDPLISTTHISLKLSAEKRGIETSIVHSSSILTAAIG
ECGLQVYKLGKPCTLALWSKGYEPTSSYDVIAENRERGLHSVVFLDIKERCMEAKEALEQ
LLGVEKEKKRLGEFHAVVLSRVGSREQKITYGEPEALLKKQLGKPPFIIVIPGKLHFMEE
EALQRFGI
>A0A7J2ZDX8|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MGELLFIGMGLWSEKDISIRGLEKLRECDVVFAEQYTGAMEEGSLKRLERMVGKRITVLS
REEVEGERRILQEAASQKVALLTHGDPMISTTHISLKLAAEKKGIKTEIIHSSSILTAAV
GECGLQVYKLGKPCTIAMWSKGYEPRSSYEVIAENKKHGLHSVVFLDLKERCMDAKEALE
QLMRIEKEERKLGEFSVVVLSRVGSEEQRVNYGKAEELLKKQLGKPPFILIIPGKLHFME
EEALQRFSI
>A0A2H9PGF4|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum sp. CG_4_10_14_0_8_um_filter_32_851|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>A0A7C4Y0E4|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGLAFIGIGLTARGLTIEGLHEAKRADYLFIDLYTSLFPKDELFVLQSLIGREVRPLRRS
DLEGRGAQKILDLAERGSVVLLTVGDPFIATTHIALKVEAVKRGIKVKYVPSASIMSVVP
GLTGLSSYKFGRSATVVFPEKGPNNAAYEAIRDNSSRGLHTLLYLDLDVESGKAMTINEA
LRILLEVEAQRREGVVRGDRLVVGIARSCWDSEVVKASKLSKLLDYDFGPPPHALVFPGV
LHFMELEALKTFAGMEECP
>A0A497GH43|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGCIAFIGLGLYGLRDISIGAIEYLRRASRVFMEKYTSILPDFKKEELEVIIGKKIEVLT
RGNLEEESGEIIIESAKEGNVAFVSIGDPLIATTHISLMLSAIRENIKVLVFPSPSIING
VIASTGLHIYKFSRPVTLTFIEEKYKYYPFTAYSVLEDNLKRGLHTLFLLDIRISENRIM
NIKEAVNVLIELERIEKRQIIDEELTIGIGIARSTAPDECVYVDILRKLKEFDFGPPPYT
LVIPGLLHQTEIEALNILGKADKEKLLRWNQRIKSSFLGRI
>A0A497GE16|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGCTFKHACFSAGRGGGVLVIIGLGLYDLRDLSLGALNALRKASRVFIELYTSIVPGFKL
EELERLIGRRVEVVLRRHLEGEWLKELIEYAREGDIALIVPGDPFVATTHITIKMEAIKR
GVKVVVYPAPSIINAVIASTGLQVYKFGRPVTIVRQTPLYSPVTPYYVLYENLSRGLHTL
FFLDLDLERGYAMTATEGIEVLRSIERREGLGIIKEYTPFIAVARASSPDEVVKVVRLGE
CVDLGPAPHTLIVPGLLNPVEAEALTLLAGAPPDLLSRWQGYVERLMKRQV
>A0A7J3CUR9|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MFRLCSLKSKNSKKVKMLYLIGLGLDVKDTSLKGLEVIKRCEKVYLEAYTNEFPYPLMKL
ERVIGKKVVRADREFVEQNSQLLEEAKKHDVCLLVYGSPLAATTHFELLLRAAKMKVKAE
VIHASSVFTAVSSCGLQLYKFGKVASIPRWQKSYAPESFFDVFLENRKINAHTLLLIDIG
LSVKDALAQLSQVAIKRGEKLDKIIVCSCLGTSRQKIFYDSLDRLKDRLKASKIATPACI
IIPASLHFLEAEALENFAI
>A0A7J2X0Y9|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MVILTLYIIGLGIREETELTEKLISILRRCKYVYWENYTSPATYNLSDIIRILEREVRVL
RREDLEERIEDIIVDAKKENVAILVCGDPLIATTHVNIILEAKRMGIEYRVFHASSILSA
GIGESGLHLYKFGPSGTIVREEKVSNKRNIDILKFNLENGLHTLYFLEYDKDEEYIMPPS
YAIKILSKYAGNILSNYNPYIIILCGIGTQNPYKRALKYNEVIKLLNKLPVDKPCIIIVS
GQLHYMEKEYIEKVLR
>A0A662ISW1|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MTSLKSSFNLNSKQGDIKIEVDLFMCLTFIGIGLTGMGLTIEGLKEAQNADFIFMDSYTS
ILPNGALNTLSSLIGKNIQPLKRADLEGRGLVKIIELAKRSKVALLVAGDPFIATTHISL
KIEAAKAGIPVKYIPSASIQTVISGLTGLSNYKFGKSATIVFPDKGPNNAAYEAVRDNKS
RGLHTLLYLDLEVEISRAMTINEGIKILLELESKRGEGVINSDMLVIGIARACWKDSIIK
ASKLSKILHYDFGPPPHVLIIPGSLHFIELEALRLFADMEDY
>M0ENT6|diphthine synthase|EC 2.1.1.98|Halorubrum californiensis DSM 19288|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRD
GVERDPEPILDAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGRD
PDHEEYMTADVAAGLLAAEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLIAI
PGDLHHVEADALAGLAGAPESLVEE
>A0A5E4JZC9|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGLGLADEKDITLKGLEAVKNCDKLYLECYTSRLSCSKESLEKLYGKKIELADRNF
VETAEVLLKESKGKNVALLIIGDPLCATTHWDILQRARELKINTEIIHNASIINAIGAAG
LQVYKFGKTTSIPFPKENFEPESYYNIIKENKSIGAHTLVLLDLDPVNSRFMSVNEGIEL
LRKIERKRDEKVFLPKDWCVGIARLGAKDQKIVSGTVTEVSDADFGPAPHCLVIPGNLHF
LEEEALKQAKTL
>D1JE08|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGLEAIRNADIIYAEFYTSPLGGKTIEAMERMYSKRIFVLERS
DIEETAEEGILKLAKYQKVVLLCGGDAMIATTHLDLRLRAIDMGIETRIVHAPSISSAVA
GLSGLQNYKFGKSITVSPVYKDVISDVPYETIIANRERGLHTLLYLDISMSIAEALKLLE
AVETKKNGNELKKSIIVGIARAGSDNPVVKADYMNILNSFEFGALPHVLIVPGKLHFMEK
EALIKIAHAPEDI
>A0A7L4QH72|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosa archaeon|TrEMBL
MLYLVGLGLTEKDLSLKAFELLNKVNNIYVDTYTNYFDFDLLWLEKALGKKVNSLSRGDI
EKNPEFLDIAKNDDVALLVSGDPLVATTHTDILLRAIKKGVKTKVFHASSIYSAIAETGL
HIYRFGKTASIPYPEENFFPRSFYDVTVENKQRNLHTMLLLDVKKEKNLFMNPREAMDIL
KKIDEEKNIKDVIVISRISHESQRIIYGDMEELIKFDKDFYGPPPHTLVIPAELHFAEEE
YLLNIAEIHKNSKSK
>A0A7J3MTL8|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MPQGMTINFVGLGLGSKDYLTRAAEEALLESEKVYLDMYTGHISSELIDYLRELLKDRLI
FAERTTIENNLYKIIDEASRNKIAIATSGDPFIATTHIAILLEAVKRGICVKVIHGVSII
SAAASYSGLSAYKFGRIVTVPRAASMEIMEGIYRVIANNQEHGLHTLVLLDTADGGVTAQ
EAAEYLSRIEEKLGWGLFRDDRIAVVLLHVGMRTASKKCYAIKDLKELSLPPPPHVMILP
GELNFVEKESLKMIAYCDYKMIDNHHPISTSRQRAKKYIDKTQGVLGKIRKEPVDLEAQE
VVELASTYVYDSQSFLLSGRTEDSLIAISYAEGLLDCLRMLGKVSFKW
>A0A7C5RNE0|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLRLVGLGLGPPEYMTLKAVKKLEESDIVYLDTYTSPLPSELVEFLRSRLADRLKLAGRS
DLEEKAGELVEKAETMSVAVAVPGDPLIATTHIALLIEAAERGVECEVVYGVSSLSAAIG
ISCLSSYRFGRVVTIPREAGEESLRTIYRSVEENIESGLHTLVLLDVSDGGLTASEAVRR
LLSVGAAVGGRFGPESLVIILARLGYADEVRTACKAAKVESLRLPPPPHIIIIPSQLRSY
EREAVGKLMHVDEELLRPDVSVGMRRSRAERYIAKASSVFAKLNILSGDAETHRILELAQ
SYLDDARFFLNSQMVDDTLIAVSYAEGLLDCLRILGRVEFTW
>A0A7J3WFI4|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLRLVGIGLGTPDYLTLKALRALEESDIVYLDCYTSIISSELIEFLRLRLGGRLVLAERS
DLEEGVAEIVKRAKSMSVTVAVPGDPLMATTHVVFLEEAVKEGVTFEVIHGASSITAAIG
ASGLSSYKFGRIVTVPKNAGEESLKTICRCVEENMESGLHTLVLLDVADGGLRAAEALGS
LLMVAAEMGGSFGPQTPVIILARLGYGDEFRVVCRASEAGGLSLPPPPHVVIVPAETRSY
EREAVKALTVRGGELLDTYRPTSRRRARAERYIAKTSGVLSKLAAARNDAETSKILELVN
SYVEDARHFLDSGMLDDSLIAISYAEGLLDCLRIIGRVEFTW
>A0A7J3RZY6|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MELLFVGAGVHGASSLPIGAIEHLKRSSKLYVDVYTSPWPEGELARLEGILGRSALRGTR
ALLEDGRAILDEAMKGTVAILCMGDPFTATTHVSLRLRAIERGIRVKTFYSSSILNAVFG
ETGLHCYKVGRVVSLIRAAPAALVSVYMAVKDCLQLGLHSLLLLEYNYDEGYHLSPSEGL
KMLQELESSYKMGVFTDDRLVVVASRVGWPSQTIVAGPLRDLIRLEFGQPPHCMIFPGPL
HFSEEEAMAKMLGSASAVKDAVAELISPSKAMVERTITKTLAALSEARRIAHESSVTNLE
AIFENVEAYLSDARRFLMEGKPELALMEAGYAEGLLDAIRLQGTLKMTW
>A0A151EIL4|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon SG8-52-1|TrEMBL
MHKGRLTFIGLGLYDEKDISLKGLEEIKRCDKVYAEFYTAKLTGTNIKKLEEAFGKPIEI
LSRVETEKGKKILDSAVNKKVVFLTAGDPMTATTHVDLRLRAIKKGIKTKVIHGSSIITA
VAGILGLQNYKFGRTTTLAYPEKNYFPTSPYDIIKKNKEMGLHTLVLLDIQEDQNRYMSA
NEGINLLLKMEEKHRAKIFNKNSILCVVARAGSDDPVIISGPISEMINKDYGPPLHSLVI
PGKLHFMEIEALQTLAQLPAQQVRKLQKL
>G2MIH0|diphthine synthase|EC 2.1.1.98|halophilic archaeon DL31|TrEMBL
MLTFIGLGLYDERSVTVEGQDALRAADRVFAEFYTSRLVGSSVDELEAYHGVDIEVRDRA
GVEQEPEPVLAAAEEEDVAFLTAGDTMISTTHVDLRLRAHKRGVDTRVIHGVSAQSAAAG
LTGLQNYRFGKATTLPFPGAHGGDDVPASVIDTIEANRERGLHTLVYLDIKVDDPTADAA
GLAEGEEYMTGEYAAELLAEGWADELAVVVGRAGSPEPVVVADRLSALAEREFGAPLHLL
VIPAVPHHLEADALRELAGAPAALLGDQ
>A0A1J4UDY4|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon CG1_02_47_40|TrEMBL
MLYLIGIGIGNEKGLTLEGAEALKKCKIVFLEDYTNLVEKETVTGIEKIAGRKVEILGRE
AVEGEKKILQAAEKEKTALLVSGDPLIATTHVSLVLSARKKGIWVKIIHASSILSCAIGE
SGLQAYKFGKSVTLAGWSRGYEPKDAYFVIEENKKRGLHTLVFLDIKEGKCMEAKEAVEL
LEETERRKKKGVIASETQMVAISSLGRKEQKISFGEIEKLKKAELGKSPSILIFPAKLHF
LEEEWLNYFKL
>A0A843JYE9|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLHFVGLGLYDERDISLKGLEAVRAADCIYAEFYTSRLMGTTLEKMEALYGRKIHPLSRQ
EVEVDPSWLEEGRNKDIVFLSGGDAMVSTTHLDLRLRAIKMGIEASVIHSSSIVTAVSGL
CGLQNYRFGRSTTIPFPYVSRGRRIIPQTPYQVLRENQERNLHTMLFLDIQMEPVERYMT
ANEGTALLMEMEANAGESGLMEAIAVGIARAGAPDASVKADLLPRLQGYSLGGPLHILII
PARLHFMEAEALRILADAPADAVQC
>A0A7J4J2D6|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGLGLHDEKDISVKGLEIVKRCDVVYVDTYTSLLQCSREDLEKFYGRKVIPAPRE
VAEQHEQEIITQAKTKEVAFLVVGDPFAATTHVELLKQAQEQGVNVKIIHNASILTAIGI
TGLQLYKFGRTISIPFLEDHPHLETPYIVLRQNLYLDMHTVFLLDLKPELKKFMTIPEAL
TVLETIEERKKEHVITPSMMVIGCARLGADDMIIKAGSLEKIKEIDFGKPPFCLIVPGKL
HFVEREMIERYAIR
>A0A7C3ZI68|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALHIVGIGLADETDITVKGLELVKKSDLVYLESYTSLLAVASTKLEQFYGKKIILADRK
TVEMDAEEKLLNPAKTKDVALLVIGDTLSATTHLDLLTRAKEMGIKTSVVHNASVLTAVG
KTGLQLYKFGKTASIPFTHQDYEPETPYNILEENASIGAHTLFLLDLRPDENRFMTVADA
IRYLQKLEIRKGKGLVKDSTMMVGCARLGSASELIVAGKAKELLKKDFGTPVHCLIIPGK
LHFVEEDSLKSLQ
>A0A3M1H9J8|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLTLIGLGLGDAKDITLKGKAAIEQADIIFLEHYTSILGCSERELEKEYGKPIILADRD
LVEKRAEEILEPAKTKNVCFLVVGDPFGATTHADLYLRAKDAGIQVKVIHNASILNAVGI
VGLELYKYGKTTSIVFPEEGWEVQTHYDAIKENLERGLHTLCLLDIKIKEARKEDLKQGR
ENPLKPRFMSVNEALRNLLSIEEKRQENIVTQDTLVVGVARIGQESQLIRAGTVKELLDT
DFGAPLHSLIIPGKLHFIEEEMIEQWKQ
>A0A1V4TWF0|diphthine synthase|EC 2.1.1.98|Methanoregula sp. PtaB.Bin085|TrEMBL
MLTFVGLGLFDKTDVSVKGLACIRQADHVFLESYTSCLMGSSADDLAAYYNKPVHRLFRE
DVEQHPDHLLDLAQEDQVVFLCAGDPMVSTTHADLRIRAAERGIRTAIIHAASIASAVCG
LSGLQNYRFGKSCSLPFPQKNWFPTTPFDVITANLASRLHTIVYLDIRTDRFMTIPEAVG
LLEHMAHDRQAEIPLYVGIARAGSDDVMVRAGSAEKIRSQDFGPPLHILVIPAELHDMER
RYLEMFAGL
>A0A843EIK7|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MVSELIFVGLGLSGADGMSVKALNALKECDRIYAEFYTSHLIGTGVDELEKAIGKKITVL
HRMQVEEGTDIIENARTSRVGFVTAGDTMSATTHVDLMIQAKEEGIPTRLFNGVSIFSAA
PTALGLQPYKFGRAVTLPFIENDYQPQSPYDNILENKERGLHTLILLDIHADECRYMTGK
EAIEWLLLAEEKWGKGL
>A0A219AL63|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp. 87.7|TrEMBL
MFYLIGLGLFDVTDMSLKAINALKEVDTVYAEFFTSRLMGSNLKSIEEIIGKKINVLVRN
EVEEDSSFIEEAKTKNVALITGGDPLIATTHSDFLVQCSKKGIGYQVIHGSSIISSAPAI
SGLQAYKFGKVTTIPFPDHNFFPKSPYNAIKENLDMDMHTLVLLDIQAHKDRYMTINQGL
EYLMKVKDILPEEEQVINEDTLAIGIARVGSKEGIVKAGKISELIDYDFGSPLHCIIIPS
KLHIVEAEYLVYVAGADKSILDDC
>F0QUA7|diphthine synthase|EC 2.1.1.98|Vulcanisaeta moutnovskia (strain 768-28)|TrEMBL
MSRGGPTLYITGLGLSPRNITTEALEVMRLVDVVFLETYTSKGPVEFMNYLRSIRNDLIL
VSREDLENRNGDVIMRELERGHDAALLVFGDPMIATTHAAIAVIAKRHGFNVKIVNSVSI
VCALLSQLGLSPYKLGSIATVTYPRMGVLSTRAYDVLGDNLKRGLHTILLLDIRDDEGFM
SANEAVDILRRLEEERKLGIVNERLLVIYVARLGWVDHRIVVSTVNNVPDIGDTPHTIVI
PGLLNPVEVDYLVHVLNASKDFVDNHQRFIHSLTVENK
>C7NPY4|diphthine synthase|EC 2.1.1.98|Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2)|TrEMBL
MLTFVGLGLYDERSVTLAGRDAIRTADRVFAEFYTSQLAGASIEEIEAFHDTDIEVRDRA
GIEQDPDPILDAALEDEVVFLTAGDTMISTTHVDLRLRAEQRGIETQVIHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHGGDGVPDSVIETIEANRDRGLHTLVFLDITVESDDGTYM
RGDQAASLLAKHWRPNALGVVVARAGSPDPVVQAGRLSALAEMDFGGPLHLLVVPGSLHY
IERDALAAIGDAPADALDENIVD
>A0A7J3WPH7|diphthine synthase|EC 2.1.1.98|Methanomicrobia archaeon|TrEMBL
MLALIGLGLDGTEISAKGLSHVAGSDEVFAEFYTSLPCVDMCDIERIVGKPITVLTREDV
EERELPLERARDGIVAFLVMGDPLVATTHISLAARAREEGIPLAICHASSIYSAIGSTGL
MLYKFGKSASIVYPEKNYFPKSFYETIVQNKKRGLHTLLFLDLKADRDIYMNPVDGMRLL
RAADEETIVSTIIVASRIGWKSEKIVYGEVSELSSLDASFFGPPPHCIVVPGEMHFAEEE
YVELFRYG
>A0A7C0XN95|diphthine synthase|EC 2.1.1.98|Methanomicrobia archaeon|TrEMBL
MLTFVGLGLYDEKDITLKGLEAVRTADKVYAEFYTSPLGGRTVEKMQREYGRRISVLERS
DLEENAEAAESGGILELAKSKNVVLLCGGDSMVATTHVDLRLRAIDREIKTRLIHAPSIL
SAVAGLCGLQNYKFGKSATVSPPYPHGCGGVISEVPYDTLKANKERGLHTLLFLDISMSV
NEALGLLETVEERRRGTVLKNKKSIIVGIARAGSEEPVVKADYLEGLKSYDFGELPHVLV
VPGELHFLEKEALVKIANFPAP
>H8I7F4|diphthine synthase|EC 2.1.1.98|Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254)|TrEMBL
MLTFIGLGLWDEKDISLKGLEAIKKADVAYAEFYTSRLMGATLEKLEALYGKPIKVLDRE
DVEQHPEDSILKDAVDKDVVFLTGGDAMVATTHVDLRLRAQKMGIQTAVIHGASIASAVC
GVTGLQNYRFGKSATIAFPYRSIVSETPYDTIKMNKANGLHTLLFLDIDKAQGYMTINKG
IELLLLVEERRKEGVLRDALGVGVARAGSPEPCVKAARLDSLKSYDFGGPLHILVIPAEL
HFLEEEALEALAGLRL
>A0A6B1BDG5|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0663_bin_5|TrEMBL
MLHIVGLGVSDDSIPYNIEDIIQKADIVYLEVFTSPDINTSQIRRICPTLQMAPRWLVED
GRRILEESEYKDVVLASYGDPLVATTHTELRVRAAQRGIPVNVVHGPSAITTLVGECGLH
HYMMGRMATIMSEDTLLETPYMVSYRNAVLGNHTLLLLEYNQDADFFLKADVALQRLSDA
EKSYRRGVFTPDRHCIVACRIGTKRQLVVSGSLSSLEGYDFGEPPHSIILTGRLHFTECD
AIRVLTRCMDGPPENQTIKSIPQQMIEKYTPMIHKSIQDLPDCSNNEKLIVQNAISYIQD
AQRALESGQDEVAILSIGYADGLVDALRISHGMDPKI
>A0A662LER1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MNKGSLVFIGLGLYDEKDITLKGFEEVKKADKVFAEFYTAKLFGTTLKDIETLIGKKITV
LSREKTEKGEVVLDSAEKHYTVFLTAGDPMTATTHVDLRIRAIKRGINTQVVHGCSIITA
VPGLLGLQSYKFGRTTTLVFPDKNYFPTSPYEVIKENKKMGLHTLVLLDVQADKNRYMTA
NEGMKFLLEMEEKNRGNVLSKDTLVCVVARAGSNKPVVKADSIKNLIKIDFGPPLHTLVV
PGRLHFMEVEALIALAHLPAQLGEKLQKI
>A0A662M956|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MKKLSLIGMGIVNERSIPLLGLDRLKEANLIFAELFTSILEEGSLERLSQLAGKEIRLLD
REDVEETEMVLGAFENADRICFLTAGDPLSATTHQEMRLDAEKRGVEVEIINAASIFTAA
PGISGLQQYKFGRTTTLAFPEEGFFPTSPLDVIESNLERGLHSLVLLDIQAHRDRYMSAP
EGAALLLRMVEKKGGSPIGPETMMVAVARAGHHDRKLVYSSLGKLSNMSLGPPPHCLIIP
GKLHFLEEEVLDSFRVE
>A0A662KB57|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MNKGSLVFIGLGLYDEKDITLKGFEEVKKADKVFAEFYTAKLFGTTLKDIETLIGKKITV
LSREKTEKGEVVLDSAEKHYTVFLTAGDPMTATTHVDLRIRAIKRGINTQVVHGCSIVTA
VPGLLGLQSYKFGRTTTLVFPDKNYFPTSPYEVIKENKKMGLHTLVLLDVQADKNRYMTA
NEGMKFLLEMEEKNRGNVLSKDTLVCVVARAGSNKPVVKADSIKNLIKIDFGPPLHTLVV
PGRLHFMEVEALIALAHLPAQLGEKLQKI
>A0A662K4X6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MNKGSLVFIGLGLYDEKDITLKGFEEVKKADKVFAEFYTAKLVGTTLKDIETLIGKKITV
LSREKTEKGEVVLDSAEKHYTVFLTAGDPMTATTHVDLRIRAIKRGINTQVVHGCSIVTA
VPGLLGLQSYKFGRTTTLVFPDKNYFPTSPYEVIKENKKMGLHTLVLLDVQADKNRYMTA
NEGMKFLLEMEEKNRGNVLSKDTLVCVVARAGSNKPVVKADSIKNLIKIDFGPPLHTLVV
PGRLHFMEVEALIALAHLPAQLGEKLQKI
>A0A662KJA5|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGELIFIGLGLYDEKDISLKGLEDAKRCNYLFAEFYTSKLTGTDISKVEKILGKKIKVLG
RKEVEDGEQILKEAEKGRVGFLTAGDPMAATTHVELRIRAEERGIATRIVHGSSVFTAVP
ALLGLQHYKFGRTTSLVYPEDNFFPTSPYYVIKENKERGLHTLVLLDIDAEKERFMTIRE
GIDILLEMENRLKEGVISDDTIVCGVARAGSKKPIIKAGSILEVRNFDFGPPLHTLVIVG
KLHFMERKALETFAGLTRENRSV
>A0A7J4F5H1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGTLVFIGLGLFDERDLTFKALDYISKSKYVFMEEYTSRLMGTTTKNIEKFINKEITLLA
RKEIEESDIILEKAERCDMVSFLVPGDPMTATTHATLLLEAKKKGIKTILVPNASIYSAA
PSLCGLQHYKFGRTTTLVEPEGDYFPKSPYYVIKNNLERGEHTLVLLDIKIDEKKDEFFL
MSPERAISLLKKMEKEEKGGVAEASRRVVIVGNAGSSSPVVVSARFGDFKEDGESHLKIE
KNLFPVGIYSLIIPGNLHFLEKEILEMCDIRRML
>A0A662M867|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGELIFVGLGLWSEKDITIAGREIAGECDTVFAEFYTSMLGVPKEKIESVIGKKIEVLSR
EEVEDGSIILDEAVSRKVCLLTGGDPMTATTHVDLRLRAIERGIYTRVVHGISIITAAAG
LLGLQSYKFGRTTTLAFPEGDYFPTSPYNFIAENMERGLHTLVLLDIGDKFMTANEGIEL
LVEMEKRERKGIIGEKTLMAVVARASSPSPSVRAGYPDELLKEDFGPPLHCIVIPGKLHF
MEAKALVMLADAPEEIMK
>A0A523YH98|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon|TrEMBL
MGLLVFIGLGLHDENDITVKGLEQARECDVLFTEFYTSHMRDGAKEELEKKLGKEIIVLS
REDVEGGEVMLLEARERTVGFLVPGDPMSATTHVALRIRAEKEGIQTRVVHGVSIVTAAT
GLLGLQSYKFGRTTTLPFSQKGYFPTSPYDVIKRNKDIGLHTLVLLDLKESGETMSVREA
IDYLMKLEMKKKEGVVTKDSLACALGDVGSDKPEVVCDRIGKLAMREFKSQIFCLVLPAE
LHFMEKEALRVLAGAPDDID
>A0A5J5L7H0|diphthine synthase|EC 2.1.1.98|Haloarcula sp. CBA1129|TrEMBL
MLTFVGLGLYDERSATVVGRDAIRDADRVFAEFYTSRLIGTDLETLADTLDTTIEVRDRA
GIEQDPEPILAAAESEDVVFCTAGDTMVSTTHTDLRLRAEDRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASHAAALLSEPLPDTLGVVVARAGSPDPLVVADTLDELAAQTFGDPLHLLVIPG
SLHPLEADALESLAGADLE
>A0A832RL63|diphthine synthase|EC 2.1.1.98|Methanosphaera sp|TrEMBL
MLYFIGLGLFSEDDISFKGFNALKNVDCIYAEFYTAKLMGGNIDNLISKVDVPFITLKRE
DVEDRNIVLEEALVKDVAFVVAGDPLMATTHTELYVEAVSKGIETRIIHGSSIFSAAPGL
TGLQAYKFGKTTTVPFPDENFFPHSPYDVIKSNKEMGLHTLVLLDIQAHKDRFMTINEAL
DYLSKVESERGEKVFSDDTIVVGLARAGSDKPLVKGGTVKEVVDFDFGGPLHCLIVPGDL
HFVEAEALITLADISKDLLEKFL
>A0A842UTJ1|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLKGLVLNEKSLTQESLEVIQKSKKIFLESYTVDFPYKISRLEKLIKKKIKRLKREDI
ESEFLIKEAKKNKISLLVYGSPLFATTHTSLLMDCRKGKVKYKILYNASVFDAVAQTGLQ
LYKFGKISSIPKWSKKYKPYSFIDSVIENKTVNAHSLILADIGLEFKQALIQLKEACMEY
DLSINKLLVCSKLGNKSKIHYSSLEKLKEKNIKRPFCFIIPGKLHFLERQFIEDFTK
>A0A1L9C6Q9|diphthine synthase|EC 2.1.1.98|Methanohalophilus portucalensis FDF-1|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNADKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKDIDIAFLTGGDTMVSTTHVDIRLRAMEMGIETRLIHGSSIVSAICGL
TGLQNYRFGKAATIPHPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMNKGYMTV
NQGIELLLKIDEKRGENLIKGSIAVGIANAGSEKPIVKADFAENLESYDFGSPLHIVAIP
ADLHFVEAESLVKLADAPESILEEGEEN
>A0A662NYB2|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MRKMGGLYLVGIGLGEKGISVKGLEIARKSDMVLLDSYTNVIDENKVKTLSGLIGKEVRL
ADRTSLEENIDPLIEESKKKRICILVPGDPLLGTTHISIVVRARELGVKCEVIPGASIFS
SIGLTGLSPYKFGRTVTIPHLEKSFKPRSFYYQIKLNKDVGLHTLVLLDTERGGMSPSVA
VTILDEIENEERLGVVSNSDLIFVLSRIGEENQHICLDRLESVISKEFGPPPHSLVLPGK
IDEVEREMIKALFGVEV
>V4XT64|diphthine synthase|EC 2.1.1.98|uncultured archaeon A07HR60|TrEMBL
MLTFVGLGLYDERSVTVAGQEAIQNADSVFAETYTSRLIDATIDEVGAHHGVAIDRRDRE
GIEQHPEPIFSAAESGDAVVLTAGDTMISTTHVALRVSAEERGIDTQVINGVSAGTAAVG
LSGLQNYRFGKAVTLPFPWAHGGGTVPASVVEALETNRQQGLHTLVYLDIKIGRGPDGPD
PDHEEYMTADTAAGLLSEAWEDTLAVAVCRAGAGQPLVTANRLSHLADRDFGDPLHLLIV
PSDLHHVEADALQTLADAPSDLV
>A0A3R7G3J0|diphthine synthase|EC 2.1.1.98|Haloarcula sp. Atlit-120R|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDLETLEDALETSIELRDRA
GIEQDPEPILEAAERESVVFCTAGDTMVSTTHTDLRLRAENRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASQAAAMLSEPFPDTHGVVVARAGSPEPLVVAATLDELATQTFGDPLHLLVIPG
SLHPLEADALESIAGAALE
>A0A662R1V0|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLFDEFDITLKGLREVKSADVVYLETYTSPLVGTNVKRLEKLYEKDVHVLSRE
DIEGAPAEKILIEALHKKVVLLSGGDPMVSTTHVGLRLRAHEMGVKTKIIHAPSIMSAVC
GITGLQNYKFGRSATIPFPYEVDGKRIVYETPYDVVKENIQRGLHTLLYLDVGERMMTIN
EGVSLLFEIAEKKGDEEFCKLLGVGIARAGSDEAFAKASELTQLMEIEFPDPPHILVITG
RLHFMEKDALIVFCDAEIT
>A0A497ITD3|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYSAKDITVRGFEAVKSADIVYFEEYTSSLGGCDRLTLEEVFGRKIYPLSRE
EIENEPEKILLHATSHNVLLLTGGDPMIATTHVDLRLRAYDRGIRTNIIHAPSIFTVVPG
ITGLSSYKFGKTATISFPYRDKAESISDLPYDTIKQNRSHGLHTLLLLDITYERQMTIKD
ALEILETLETRHGEGLMKDLIFVGIARAGSEDMVVKAGGMKTLMEFDFGTPLHVLVAVGD
LHFMEEEALCKFAGLERDL
>A0A2R6EK97|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_7_66_37|TrEMBL
DIDGENERFLTGDRAADLLAEPLGDPLGVVVGQAGSDDPTVRADRLSTLAGESFGPPLHL
LVIPAEPHPLERDALVELAGAPEPPANGG
>A0A7K4HM29|diphthine synthase|EC 2.1.1.98|Methanofollis tationis|TrEMBL
MLTFIGLGLYDETDISIKGLDRIRRSDHVFLECYTSVLTGTTPEQMTELFGKEVGMLYRE
DVEGHPETFLELAKESDVAFLTAGDPMVSTTHIDLRIRAAAMGIRTEIVHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGKWAPTTPIEVIEQNIADKLHTLVYLDIQPDRYMRIPEAVR
MLEEMAAARGVSIPVYVGVARAGSGSPVVAAGTAAALAGVDFGGPLHILVVPGDLHLMER
EYLETFAGL
>A0A662Q9Q2|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MDNMPLYLIGIGLGSRGYITREALDAMSRSEKIYLDTYTSILDDDLLQYLRENFSDKLIE
ADRKLLEDEASKIVEEARLRRISIAVPGDPLIATTHIAILIEAAKRRIPYRIIYGVSAYS
ALISASGLQAYKFGRTTTIPRDGVGIETCYNIILENMERGLHTLVLLDTAGGGLEIPEAI
KMLYKVEEKYGEGLISENRLIICLARIGFKDEFKWAGRISDAIDLSYPPPPHTMIFPGSL
HFSEADALREIYGVDSRILESHNPIRFWTMRLAKYISNVEHALKTLKILDERREVNEVLN
LSRSYLEDSIRFRERGRLFDSLAAISYSEGLLDSLRILRAVEFSWRRENSRE
>A0A533WTZ3|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MLWFVGTGISGYRGLSFDAVDTLKKCDLVYVERFTSALSDNDLHGLNSILGREVRSVQRW
FVEDGREILEAAKTKQVALVTYGDPLIATTHSELRSRAARNSIKTAVLHAASGLTSIMGE
SGLHVYKFGRMVTMMSEPQSAVSVYNTILENLLAGSHTLILTEYSHDESKEPFFLDPASL
FKMLLDVEHDQKHQIFSDNTFAVVASRVGMEDQRVTSGKVGSLAKIDFGIGPHSVIVTGS
LHFTEAEAIAALTVNIDGPADNSQTVKRISVQMVERYAPKAKQAVQQMREVVRQDAGSKG
MYEVLDNAEYYIADAERFLRQAKFELAVLSIGYAEGLVDALRFQKGINPWEIRG
>D7DTK9|diphthine synthase|EC 2.1.1.98|Methanococcus voltae (strain ATCC BAA-1334 / A3)|TrEMBL
MLIMAGLGLYDEKDLTLKTLENAKKADKIYAEFYTAILTGTTLEKIEETLGKKVNVLDRE
KVEYETEQLIEESKEKNIMFLTAGDPMVATTHVDIAVEAKKKGIEVIIINAPSIYSAIGI
TGLQIYKFGKTTSIVFPEPNYFPETPYNVIKDNLSLGYHTLCLLDIHAHENKFMTANEGL
QVLLDIEKRREEKLLSEDTKVLVVARAGSLKPKLVYGKIKDLIKQDFGAPLHSIIILGNL
HFMEEEALEILAENV
>A0A7J4B1Q6|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLVGLGIWDEKDMSIKGIEICKNADKIYAELYTATWGGSIKNLEKIIGKKITLLQRKD
IEEDSENFIKEAKKCDIV
>A0A835WYJ7|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFVGIGISGIDSISISTQKLLKQADFVYLEQFTSPFSKNEVTKIKKFANGNFKIAKRW
MVEDGKEILKNAKRNEVVLLSYGDPYIATTHIELRTRAIQNKIKTGSVHAASSITSLVGE
CGLHYYKIGRIVTIMKELKALTTPYYVIYKNLIDGNHTLLLLEYDQDSKFFLNPKNALVA
LINTEKEQKRKVILPSTFVIVASRIGLQNESITSGKISVLKKRDFGKPPHTIIIPGNLHF
TESDAIKELTNCITKPIDNSEKIKKIPKQMIEKYVPMVRKSLKEITPHFKNSKHFQEVLQ
NAELYVKDAEIFLEQGKDEVAILSIGYADGLVDSLRIAKGLEPKK
>A0A832Z2T1|diphthine synthase|EC 2.1.1.98|Archaeoglobus profundus|TrEMBL
MLIFVGLGLWDEKDMSYKGLEIAKSADEVYVEFYTSKLMGSSLDRLQKFIGKEVKILERS
DLEENSEWLIQRAKDRDIVILTPGDPMIATTHSALRLEAEKRGIKTKIIHSSSIMCAVCG
LTGLHSYRFGKSATVCYPYKGIIPKTPLNVIKQNLSIDAHTLLYLDLHPKPMTIREAIDI
LMKADDDNILIDLFAVGIARAGSDNPFVKCDKLLNLRKVNFGSPLHVLVVLAKTLHFTEY
EYLRMFASAPEELKEIVI
>A0A832JY53|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MLVFLGLGYSLRHITLEALEVLKSADVIYVDTYTSMYEDPLDEIKQFNPDAKYIYASRRD
LEGSPIDHIINEAKSKLVVIAVPGDPLIATTHDALWISAVKSGIRVKVINGLSFITMAYS
RLGLQSYKFGKHVTLVHPSLFKSYSTVDTIYGNLERNLHTIVLLDLRIEEGYVMTINEAV
QVLLELDYKGQLGDQLAIGVARLGWRDEKICASRLKHLVNFKYPPPPHSLVVVSSRLDPV
EEEFVKMWSSMC
>A0A483CQV3|diphthine synthase|EC 2.1.1.98|Methanofollis fontis|TrEMBL
MLTFIGLGLYDETDISLKGLERIRRSEHVFLERYTSILTGTDPGRLEALFGKPLRMLDRE
DVENHPETFLTLAKDADVAFLTAGDPMVSTTHIDLRIRAASMGIETSIIHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGRWAPTTPIEVIEHNMAENLHTLVYLDIQPGRYMTVHEAVG
MLEGMAAERGLSIPVYVGVARAGSPSPVVAAGDAAALEGVDFGDPLHILVVPGDLHLMER
DYLETFAGL
>A0A075FSI6|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote AD1000_44_E12|TrEMBL
MTQGLHSVILLEYNHDEDYFLDPKNAISNLLDIESEQKMNVLNDDTFAVIASRIGFETQK
IISGKFGNLIKGNFGEPPHSIIITGKLHFTESDAINVLTECLDKPSDNSSRTKSTTVQMI
EKYVPMVRKALEEIKPLYNNSKEFQEVFENAELYIDDAENFLKQGKDENAVLSIGYADGL
VDALRMAKGIEPKM
>A0A3S3S7F4|diphthine synthase|EC 2.1.1.98|Candidatus Methanosuratincola subterraneus|TrEMBL
MPSLAFIGLGLYDEKGISLHGLEIAKSAEIVLLESYTNIMPGLNLESLGKMIGKEIRLIG
RREVEDGKWILDAAAKREVALLVAGDPFVATTHVDLRLRAIKRGIRVEVVNAPSIVSVAP
GAVGLQNYKFGKSATITFPEPLSLVPYETLRINRSLGLHSLFFLDLRVEEGRFMKAGEAI
RLLLDMEAKQRGGVVSEEMLMVVLARAGSPSQLVRAGKAAVLEDLDFGPPPHSLIVPGRL
HFMEAEALVLIGGADEDLVRGYL
>A0A3P3RER5|diphthine synthase|EC 2.1.1.98|Halomarina oriensis|TrEMBL
MLTFVGLGLYDEHSITVAGRDAISKADRVVAEFYTSQLTGTTLETLEAYHDVAIEVLDRV
GVEQQPEPILDAAMTDHVVFLTAGDPMISTTHVDLRLRAAERDIDTRVIHGTTAQAAASS
LTGLQNYRFGKATTLPFPSAHGGDAVPTSVLDTIETNREHELHTLVYLDIKAEREEFMRA
STASELLYEQYEDVLAVAVCRAGSDDPVVVADQLSALASRAFGPPLHLLIVPGTLHHMEA
DALAELAGAPQDCLDSYSV
>A0A1G8XUN0|diphthine synthase|EC 2.1.1.98|Halovenus aranensis|TrEMBL
MLSFIGLGLYDERSITLRGRDVLADADTAFAEFYTSQLVGTTVDQVESTHGIDIEVRDRA
GIERDPEPILTAANGGHAAMLTAGDTMISTTHVDLRNRARDRGIETQVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEETHGGVPDSVIETIRANRERDLHTLVYLDIDAANERFMTGDT
AASLLAEELDDPLGVVVTQAGSDDPAVRADRLSVLAEESFGSPLHLLVMPATCHPLEEES
LKTLGDAPATAFK
>A0A2H9QX10|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon CG_4_9_14_3_um_filter_38_12|TrEMBL
MGKITFIGLGLFDEKDITLKGLENIKKSDKIFAEFYTARLMGTSKEKIEELFGKKIRILS
RKEVEDGKIILDAAKNKNIAFLTPGDPMTATTHVALRIQAAERGIKTKIIHGVSIVSAAS
GLLGLQSYKFGRTTTIPFPEKDYLPESPYDVIRQNKENGLHTLILLDIKSDRLMTANEGM
KILLRIEEKRKEKVITQETLMCVVARAGSDDCLVSADYVKALLNKDFGMPMHSLIMPGNL
HFMEAEVLVKMANAPESIIKEPINQNH
>A0A3M6JWE7|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPISKSDLTKIKKATKGEFRPAKRW
LVEDGTEILDNAKKKKVVLLSYGDPYIATTHIELRERAIKDKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LIETEKGQRRKVISSSTYAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNAEKTRKISVQMIEKYVPMVREALEEVQPYYKDQKEYEVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A7J9QQP5|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
LLSYGDPYIATTHIELRTRAIEEKIKTKSIHASSSLTSMIGECGLHFYKVGRIATIMSEM
KSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALMGLVETEKGQKRNVIDSSTY
AVVASRVGFANQSIISGKISSLKKMDFGKPPHTVIITGRLHFTESDALKILGDCLDEPTD
NSEKTKKISIQMMKKYVPMVREALEEIEPHYKGQKEYQIILENAELYIQDAEKFLEDGQD
EVAILSIGYADGLVDALRLAKGFDPKM
>A0A842MBT6|diphthine synthase|EC 2.1.1.98|Candidatus Methanosuratincola sp|TrEMBL
MPSLTFVGLGLNDERGISLHGLERARAADLVLLEHYTNVMPGLSLESLGKLVGKEIRVVG
RREVEDGREILDAASRSEVALLVAGDPFVATTHVDLRLRAIKRGIRIEVVNAPSIISVAP
GAVGLQNYKFGRSATITFPEPLSFVPYDVLRVNRDLRLHTLFFLDLRLEEGRFMRAGEAV
RLLLEMEAQQKGGVVSEGTLMVVLARAGSPSQIVRAGRAIQLADLDFGPPPHSLIVPGRL
HFMEAEALVLIAGADEDLVRGCL
>K2RTG2|diphthine synthase|EC 2.1.1.98|Methanobacterium formicicum (strain DSM 3637 / PP1)|TrEMBL
MLYLVGLGLYNEKDISLNGLEAIKSADIVYAEFYTARLFGGDLKSLEALAGVTINILRRE
EVEEEDLPIKQAETKNVVFLTAGDPLMATTHSDILMEARKKGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEENYFPHSPYQVIGENKKMGLHTLVLLDIQAHRDYYMTANEGL
EYLIRVEDERKEGIISEDSLAVVIARAGSPEPLVRADRVNALTGEDFGGPLHCIIIPGDM
HFLEAEGLVVLADAPESILEED
>K6T148|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. Maddingley MBC34|TrEMBL
MLYLVGLGLYNEKDISLNGLEAIKSADVVYAEFYTARLFGGDFKSLEKLAGVTINILRRE
EVEEENLPIKQAETKDVAFLTAGDPLMATTHSDILMEARKKGIKTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEENYFPHSPYQVIGENKKMGLHTLVLLDIQAHRDYYMTANEGL
EYLLRVENERKEGLITEDTLAVVIARAGSPEPLVRADRVNVLTGEDFGGPLHCIIIPGDM
HFMEAEGLVILAGAPEYILAED
>L9ZKF3|diphthine synthase|EC 2.1.1.98|Natrinema altunense JCM 12890|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRVYAEFYTSKLIGTTIEDLESAHDTEIEVRDRA
GVEQHPDDMLEAAEREDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKTEREEYMTA
DTGATLLAEEYPDLVGVVVARAGSPDPLVEAGTMSELTNRDFGEPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A0W8FJG2|diphthine synthase|EC 2.1.1.98|hydrocarbon metagenome|TrEMBL
MLFFIQEILYGMESRTGPAAPSSCSHDGCYRPVPGCRAHAANRGPPGVLIFVGLGLYDER
DISVKGLECVRNAGHVFLEAYTSRLMGTDISRMERLYGKRVQVLTREDVELNQEIILDRA
RTADVAFLTGGDPMVSTTHTDLRMRAAAAGIETLIIPGASIASAVCALSGLQNYRFGKSC
SIPFPAPGWFPTTPLETIAGNRTLNLHTLVYLDIQQERYMRVAEAIELIEAMAERSGTPA
PDLYVGIARAGSGRPCVAAGTGERLKSVDFGPPLHILIVPGDLHPMEREYLEMFAGL
>A0A133V7U9|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA261F17|TrEMBL
MLIFIGLGLQEKGLTLEGLEEAQNADRTYAELYTSLIPDLDLDALSEKIGKKIKVIERED
VEEHPDEILETAKSEKVAFLVPGDPMVATTHVDLRLRAEKAGIETRIIHGASIEIAAPGL
AGLQSYKFGRSATIPLPEKPSKTPYEVLVQNQEDGLHTLLLLDIEAPEERYLTANEAMEI
MLDLESKGGKNVFTQETLVAVIARAGSEKPTVKAGKVGDLIDFDFGSPPHVLIVPGKLHF
LEAEALQVFGGAPEEVEGYVE
>U1NT13|diphthine synthase|EC 2.1.1.98|Halonotius sp. J07HN6|TrEMBL
MLTFIGLGLYDEHSITREGEAALRDADRVFAEFYTSRLLGASVEELESHHDIEIEVRDRS
GVEQDPEPMLAAAAEGDVAFLTAGDTMISTTHADLRVRAAERGIDTRVIHGVTAETAASG
LTGLQNYRFGKAVTLPFPAVHGAGDVPPSVIESIDANRERGLHTLVYLDIKIDTHAEMSV
DDPFMRASEAAALLAESWGDELGIVVARAGSPEPVVAADRLSALADQSFGEPLHLLVIPG
DLHHVEADALESLAGAPPALLPDEV
>A0A4U7BXU1|diphthine synthase|EC 2.1.1.98|Halorubrum sp. CGM5_25_10-8B|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A7K3ZEA3|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon|TrEMBL
ELIGKPIQVLSRRDLEDDNGKRIFAVAENGKAVFLIPGDPFIATTHVTLRIEAAKRSIST
RIIHGASIISAIIALSGLHNYKFGKTVTIPFRENFSQTPYNVIAQNKQLGLHTLCLLDLN
VEEKRYLPIKDALIMLQEIEQKNQKEVTADDSIVVGLARAGSNNPTLKAGFLADLIDYDF
GPPPMSLVFVGQLHFLEADSLIAFANAPSKLRSLCV
>A0A2G9LQS6|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG11_big_fil_rev_8_21_14_0_20_43_8|TrEMBL
MVLHMIGIGLCDERDISVKGLEIVKRCDRIFLESYTSRLCCSKEDMEKLYGKEIILADRD
LVEKNSDEIIMPAKDSDVAFLVIGDVFSATTHTDLLLRAHENGVEVDIIHNASVLTSIGV
TGLELYKFGKTTSVPYPEDGFRPETPYEVLMDNLSLGYHTLLLLDLKADLNRFMTVSEAV
RYLLEIEEKRCEGVFTKETRCIGCARLGCGDMKVVYGTASDIAMLDMGGPLHCLIVPGKL
HFMEEEAIKRFDI
>A0A842KAP1|diphthine synthase|EC 2.1.1.98|Nanohaloarchaea archaeon|TrEMBL
MLYIVGLGLDDGEVTQKGLEALENAEKVFAEFYTNTETIDLAELEEEAGKNIEKLSREEV
EREDKIIGSAKETDTAFLVSGNALTATTHYDIKHRAEEKGIDVEVVHAPSIFTSIAETGL
NVYKFGRTVTLPKKGEPSSIVKHIEKNDSIDLHTLVLLDIDYDASEAAEKLVSMEESLGS
RKVVVLERANLEDQNISVMKLEGAAEAEFGGTPHSIIFVGETSHKEEEFLSAHS
>A0A2H4ZZ70|diphthine synthase|EC 2.1.1.98|Haloarcula taiwanensis|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDLETLEDALETSIELRDRA
GIEQDPEPILEAAERESVVFCTAGDTMVSTTHTDLRLRAENRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASQAAAMLSEPFPDTHGVVVARAGSPEPLVVAATLDELATQTFGDPLHLLVIPG
SLHPLEADALESIASAALE
>A0A5N1LKK5|diphthine synthase|EC 2.1.1.98|Haloarcula sp. CBA1131|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A8K1DCU5|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotalea sp. TS|TrEMBL
MLWFIGLGIAGIDGVGQDTIKILKKADLVFFENFTSPIPKSDQSKIKKLVKSRFRVAPRW
LVEDGKTILAEAKKKTVVLLAYGDPYIATTHIELRTRAETEKIKSQDDTCSVCNTIPCWR
VRTTILQNWTPRHCNERAKVLEHRIPYHIREPCKGHT
>A0A6B1IJU8|diphthine synthase|EC 2.1.1.98|Halorubrum terrestre|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKSTTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A257AQW8|diphthine synthase|EC 2.1.1.98|ANME-1 cluster archaeon ex4572_4|TrEMBL
MLTFVGLGLYDEKDITLKGLEAVRTADKVYAEFYTSPLGGRTVEKMQREYGRQISVLERS
DLEENAEAAESGGILELAKSKNVVLLCGGDSMVATTHVDLRLRAIDREIKTRLIHAPSIL
SAVAGLCGLQNYKFGKSATVSPPYPHGCGGVISEVPYDTLKANKERGLHTLLFLDISMSV
NEALGLLETVEERRRGKVLKNKKSIIVGIARAGSEEPVVKADYLEGLKSYDFGELPHVLV
VPGELHFLEKEALVKIANFPAP
>A0A202EC49|diphthine synthase|EC 2.1.1.98|Natronolimnobius baerhuensis|TrEMBL
MLTFIGLGLYDDRSITVEGRDALRDADRAYAEFYTSKLIGTTLEDLEAAYETDIEVRDRA
GVEQEPDDILAAAKDEDVAFLTAGDTMISTTHVDLRLRAHERGIETHVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTNTIDDNRADGLHTVVYLDIKAAREEYMTA
STGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMDELADREFGDPLHLLVIPGDCHLLEA
DALVELAGADRGALEIA
>A0A7J4LTD8|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedenaceae archaeon|TrEMBL
MLTFAGLGLFDEKDITLKGLEAVRGADIVYAEFYTSALMGTTIEKMEKLYGKKIRILHRE
DIEQSPTWLLDAKDKNVVLLTGGDAMVATTHVDLRLRAHEMGIQTRIIHAPSISSAVCGL
TGLQNYRFGKSATVPFPWGRPAATPYDVIRKNLENDLHTLVFLDIDREKGYMTLNQALEL
LLEVESTRDKKILGDSIAVGIARAGSDSPLIKADYIGKLREFGFGEPLHILVIPASLHFI
EAEALVRFAGAPPEIMPRR
>A0A2I8VGZ3|diphthine synthase|EC 2.1.1.98|Salinigranum rubrum|TrEMBL
MLTFVGLGLYDERSVTVEGREALRRADRAYAEFYTSRLVGTTVEALEAYHGQEIEVRDRA
GVEQHPEEMLDAAAEENVVFLTAGDTMISTTHVDLRMRAEGRGIDTRVVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGGEGVPPSVVESIEANRERGLHTLVYLDIKVGDVPGKES
AEDEFMTGDVAAGLLAEWEDALGVVVARAGSPAPTVVAGRLSALAEREFGGPLHLLVLPG
TLHHLEADALLALCGAPEDAVEALLA
>A0A832ULT2|diphthine synthase|EC 2.1.1.98|Candidatus Undinarchaeum marinum|TrEMBL
MIKIIGIGLWDERSMTIKAQEEAADCDIIYAEFYTSKMFGSTLKKLEKKIGKEIQELSRE
EVESGKEILKKAKKQKVGLLVGGDAMTATTHAQLILDAAKAGVESKIIHGVSIFSAAAGL
SGLQSYKFGKTVSIPFEDLESPYNVIEENQSIGAHTLCLLDIRDGKFMTVNEAIRKLLKI
EKAREENVFMKDSLAVGIARAGSPKPVVKAGTAEELLKKNFGEPLHVLIIPGKLHFAEEG
ALELLKK
>A0A2R6FUZ5|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_9_66_26|TrEMBL
MLAFVGLGLHDERSITIEGQATLGDADRVFAEFYTSKLAGATIEDLETHHDTEIEVRDRA
GVEQDPEPILNAAERGEVAFVVAGDPMISTTHTDLRLRAHERGIETRVIHGTTAQAAASS
LTGLQNYRFGKATTIPFAYGDGDREGHVPESVIDTIDANRERGLHTLCYLDIKAEEDRYM
TASTAAERLAPRLDDPLGIVVARAGSPDPVVRADRLSALAERSFGDPLQLLVVPGDLHHV
ERDAITV
>A0A1F5DFE7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon RBG_13_38_9|TrEMBL
MDNNLTNLILIGLGLHDENGISLQGLEEAKKATYVFAEFYTSYMPAIKISNLEKLLGKQI
KILSRKEVEEYTQENILVHAKKYPCVFLTPGDPNIATTHIDLRLRAENEGIRTSIIHSAS
ISSAIAGATGLQNYKFGRTVTIPFKSTSISEIPYENIFENKSRGLHTLALLDINSESRLF
MSIPEGLTIIIEIEERLRKRCTTRNTLAIGVARLGSPDASVKAGTIENLLRFNWGDPPHC
IVFPGKLHFMEIEALKILCKADPELFEI
>A0A7C7QNS2|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLVFIGLGLHGEGISLQGLQAAGEADTIYAELYTSLVPEFNLKEFERKIGKSIHVVNRKT
VEEQPDEILKAAKTDKVAFLVPGDPMVATTHIDLRLRAAKAGIETKVVHAASIASAAAGL
AGLQSYKFGRVTTIPFPDNLSQTPYEALVENRARRLHTLFLLDIRAEEGRAMTANEAIGI
MLELEKKLQKNVFTQDTLVVVVARAGSDNAQVKADKVERLQRFDFGPQPHVLIVPGKLHF
VEVEALKVFAGAPEEAVG
>A0A7J4FL20|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVFIGLGLFDEKDISLRGVEEAEDADFVFAEHYTSLLAGFSLSRLERIIGKDVTVLDRRA
LEDEDGELILRRAEKGKVAFLVPGDPLIATTHIDLRIRAEKRGIKTRVVHAASIVSAVMG
LSGLHNYKFGRSVTVPFPGDGVVSETPYGVIVENKMRNLHTLCFLDVDAEKRRYMKIREA
LEVLLSLEEKIGKGVLTSESLAVGISRAGAEDGVVKAGSIKDLMVFDFGDPPHILVIPSE
KLHFMEVEALCVLAGAPEWIKEMIK
>A0A7J3F2C4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELIFIGLGLADCFDISLRGLEEVRRADYVFAEFYTSFMPGFNTEEFRRISGKNLTIVS
RRNIEEEDGALILEKAKCGKAVLLVPGDPLIATTHIALRLKAEKIGIKTRVIHGSSILSA
AIGLSGLQNYRFGKSITIPFPERGELSRTPYFVIAENKARNLHTLCFLDIRVEESKYMTI
NDALKILLELEGRIGQNIVREGSLAIGIARAGSENVIVKADAIGELMKFNFGGPPHTLII
PAEKLHFMEADALITLASAPEWVMEMIG
>A0A537FRR7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDSVAFLVPGDPMIATTHISLRLSLSKTGIGSRIIHGPSIMSA
VCGATGLQSYKFSKTVTIPYDPPLPASVLETISDNHGRGLHTLLLLDVKADQNKQLTIAE
ALTKITSANPSLESRLAVGVARIGARDERVKASRIGLLINEDFGGPPRSIVVVGKLHFME
ADALRIICGAQDSDLRENY
>A0A7C2M8W2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKELVFVGLGLYDEKDISLRGLEELKDADTVFAETYTSLMPGLSIKKLEEMIGKQIVIVP
RRVLEEEDGELIFEAAKKGKAAIIVQGDP
>A0A3R7DQ83|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVFIGLGLFDERDISLRGLEEAEDADFIFAEFYTSLLAGFSLQKLERIIGKSIAVLSRRD
LEDENGEIILQKAKERKVAFLVPGDPLIATTHMDLRIRAEKRGIKTRVIHAASIVSAVMG
LSGLHNYKFGRSVTIPFPENGILSHTPYEVIMENKMRNLHTLCFLDVDAEKRRYMTIREA
LEILLMLEEKIGRGIVTLDSLVVGVSRAGAEDGKIKAGTIKDLLAFDFGGPPHVLVVPSE
KLHFMEAEALCTLAGAPEKIWEMVV
>A0A497JPL1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLCSERDITLRGVEEARTADNVFAEFYTSLMPNLALSELERLVGKKITVLS
RKDLEEDSGERILAAARRGKAVFMVPGDPLIATTHVELRVRAVKAGIKTRIVHNASIISA
VAGACGLQNYKFGRSVSIPFPNGGIFYEAPYDTIKTNKQLGFHTLCFLDIHAEEKRYMTI
REAVEILFALERKRREKIVTADTVAVGIARAGCVDTVAKADFINALAQFDFGNPPHCLVF
PGKLHFMEAEALITLCSAPEKVKELVQK
>A0A550H2M5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSALKELVFVGLGLHDEKGISLQGLEESRTADQVFIELYTSILPCFSMQRFEAFINKQIH
VVSRHDLEEECGRVLLKAAEKGKAVFLVPGDPFIATTHVALRIAAKKRGVKTRIVHGASV
MSAIIGLSGLHNYKFGKTVTIPFPENLSETPYNVIAQNKKLGLHTLCLLDIKTDEKRFLS
ISEALMLLLKIEQKRKQGVITQDTIAVGVARAGSGAPALKADFVKDIVEFNFGDPPQSLI
FPGDLHFMEAEALVALAGAPKRVKRLGK
>A0A550GXC7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKELVFVGLGLNDEKGISLQGIEEIKTADHVFLELYTNFLPDFSIQRFKGIINKQVHIVT
RYDLEEKNGTLILKAAEESKTVFLVPGDPFIATTHMAIRVEAERRGVKTRIVHGASVLSA
IIGLSGLHNYKFGKTVTVPFPENYS
>A0A846PF07|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
RVLTADSLVVGIAQAGSPRPTVKAGSIKDLIGYDFGKPPHSIIFPGSLHFMEAEALIHLA
DGPERLRRVAE
>A0A371NC87|diphthine synthase|EC 2.1.1.98|Methanothermobacter defluvii|TrEMBL
MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRNVKVLGRG
EIEEERIPIERALELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGL
AGLQAYKFGRIITIPFTSDNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTASEGL
RYLLKASEKLDDDTISGENLAVVIARAGSEKPLVRADRIAALVDEDFGDPLHCLVVPAGL
HFIEADYLVEIAGAPRAVVERMIL
>A0A7C2UIZ4|diphthine synthase|EC 2.1.1.98|Fervidicoccus fontis|TrEMBL
MVTLSTCSGEIYFVGLGLCEKHITLEAAELLRRADRVFFEGYTSFYHPDVIDALNRIGVS
RENVVVLSRRDLEDKSGEVLLREVLNGKKVALSTIGDPFIATTHSVLKTMFQKKGCRVKY
VPSVNILSYSISSTGLFAYKFGESATIVYPRDGILSTYPYIVMAENLKRGLHTFFFLDID
EERGPLNAKEAVKLLLEAEKIEGRRAFSEEREVIVVERAAW
>A0A075GP27|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_167_H09|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQEADFVYLESFTSPISKQHEDEIKNMVKGSFKIAKRW
LVEDGQEILNASKSSTVVLLSYGDPYVATTHIELRTRAKLENIKTNTFHSASVITSMIGE
AGLQFYKVGRLVTIMNEKKSTITPYTVIFKNLAQGLHSIILLEYNHDENFFLDPKNAISN
LLDVEKEQKRGVLNNDTFAIIASRIGFDTQKIISGKFSNLLKTDFGEPPHSMIITGKLHF
TESDAISVLTECLDKPLDNSDRIKSISVQMIERYVPMVRKALEEIRPLYNNSEEFQEVFE
NAKLYINDAENFLKQGKG
>A0A832Z9J6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLYLVGVGLVPEHITKEAVEAIKRCERVLLDVYTVPVQEDQIGELEKIAGKKMERAERKV
LEDGAAELVEEAREKDVAVVTFGDPLAATTHVALTLTAEKKGVSWKYVPGVSVLTYVPSR
LGLEHYKFGWTVTVPEQWAHAPSFYERIRGNLKRRMHTLVLLDVGSGAMSIVEGLEALLH
WAERLGRGWDKVVGVARAGHRDEKIVYGYPEELMETEWPEPPHSIVVPGKLHPVEEEALG
RFVRGKR
>A0A7J9PZM6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MAKLIFIGLGLGNEKGITLNGLETARSCDSAFMESYTSILEEGSVPKLEEMFGKKIHILD
REGVETGMEVLEHAAREDVCFLVPGDAMSATTHVDMRLRAHALGIPTEIIGGVSAFTAIP
AMLGLQNYKFGRTITVPIPEPNFNPTSFYERAHDNFKMGMHTLCLLDIQKDRGRFMTANQ
ALEVLAIIEEDLQQDFMTPDRLVCVVARAGSEDCLAKAGYLKDMLKQDFGPPLHSIVIPG
DLHFLEAKALVELAGAPAKILTEE
>A0A7K3YFV3|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLYDLGDISVKGLECVKNADTVFLEAYTSRLMGTDLSAMEAFFGKAIRVLGRE
DVEQTPHEILELAAAGRVAFLTGGDPMVSTTHADLRLRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTTPIETVAENLALNLHTLVYLDIQNDR
>A0A521EJR3|diphthine synthase|EC 2.1.1.98|Halorubrum cibi|TrEMBL
MLTFIGLGLHDERSITVEGRKALRSADRVFAEFYTSRLVGADVADLEAAHGVDIEVRDRE
GVERDPEPILAAAEAGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGGDGVPGSVRETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADYAAGLLADGWRDELAVVVARAGSPDAVVDADRLSALAGREFGDPLHLLVI
PGDLHHVEAEALVGLAGAPESLLEE
>A0A087RNB8|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote SCGC AAA799-O18|TrEMBL
MLWFVGLGVSGRDAITKEVEKIIQEADLVYLESFTSPIYKEHVEEIKNLVKGNFKIAKRW
LVEDGQEILKVAKNSTVILLSYGDPYIATTHIELRTRAKLENIETKTVHSTSVITAMIGE
TGLQFYKVGRIVTIMSEKKYITTPYRIIFRNLIEGLHSVILLEYNQDESFFLDPKNAILS
LLDAEKEQKRNVVNENTFAVVVSRIGFKTQKITSGKFTNLLKIDFGEPPHSIIITGKLHF
TESDAVNALTECLDKPLDNSNEIKSTSTQMIEKYVPMVRKALEEIKPLYNDSNEFQEVFQ
NAELYINDAENFLKQGNDENAVLSIGYADGLVDALRIAKGIEPKM
>A0A498FWM0|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Atlit-26R|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEAHHDVEIEVRDRA
GVERDPEPILEAAESGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAARLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVEE
>A0A2R6DSI4|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_1_68_42|TrEMBL
MLTFVGLGLYDERSITVAGREAVRSADRVVAEFYTSELAGVSLADLERFHGVDIEVRDRD
GVEGSPDDFLADAESGDVVFLTAGDTMVSTTHVDLRLRAHERGIETRVVHGTTARTAASS
LTGLQNYRFGKATTLPFERSHGGDGVPASVLETIAANRERGLHTLVFLDIDAAGDAYMRA
DAAAGMLATALDEGDDETVVDATSGGSTLGVAVARAGSPSSVVRADALSTLAGESFGDPL
HLLVIPGELHHVERDALAELGGAPERVLPDLR
>V4XS64|diphthine synthase|EC 2.1.1.98|uncultured archaeon A07HR67|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSRLVGADAEALEAAHGIEVEVRGRE
GVERDPEAILAAAETGDAAFLTAGDTMISTTHTDLRLRAESRGIETRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGGDGVPASVVETIEANRGRGLHTLVYLDIKVGTGPSGLD
PDHEEYMTADRAAALLADGWDDALAVVVARAGSPDPVVVADRLAALADRTFGDPLHTLVI
PGDLHHIEAEALVGLADAPESLVEE
>A0A497RBG6|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon|TrEMBL
MLTFVGLGLWDEKDVSIKGYEVVKKADEVYVEFYTSKLIGTNINKLSEFFNKEIEILDRK
DLEEESWRIIEKALKRNVVILTPGDPMIATTHSALKLEAERKGIKTSIIHGSSIVSAVCG
LTGLHNYRFGRSATISYSYKGKVSKTPIDVIKKNWDMDAHTLLYLDLHPKPMSINEALDI
LLELEKMEDKYAVGIARAGSEEPFIKCDRIGKLLNVDFGEPLHVLVILAKTLHFMEFECL
KEFANAPDGLKELVS
>A0A7J4SQU2|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MSLLLLAGLGLDFGISDEKLKQIEKCKTIFLENYTNLVSKGEMGKLKTIFQKTKKGIIVL
GREQVENEKIILDAMANGDVALLVSGDPLIATTHHSLVLSAKKANHKTKIIHSSSIISAA
ISESMLQVYKFGKIVTIPFPRNGFDPTSPYENIGFNLKNGLHTLLLLDIDSEKGAMPPNE
AFEILEGWEKKLKKKVITEKTKLLVLSSIGKDDSKVVYGTIVQLRKLKFNNPPHCLILPA
KLHFMEEELLAFFCLNG
>A0A662I1P5|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MTGILGFVGLGLGKGDITLKGLEFLRKCSIIYFDTYTSLSSEINQAYLEELTGKKVKPVN
REFLETEKRKEIYQRCLKGENVVIACIGNPFFATTHVALRIEAEKLGIKTEVFNSFSILD
GILSATGLEPYKLGKIVTIVYPEPEYGYFPTTPYKVLQENLARGLHTIFLLDLKLEKKLA
MTIPEAIELLTSMEKQFNEGVITEATIGIGLARVGTSTQVVKAGKLRKLEKMDFGEPPHT
LVIPGTLDPVEREALKILGNIEDEAITEWLQRLKEKPKNT
>A0A843LFG6|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MTFYLIGTGLNAESLSWEALKIIRKCKQVYLENYTVDFPFEKKRLERTCNKKIKELQREE
VESEEFLDKAKKENIALLVYGDSLSATTHSELILNCMKKKIPHQVIHNASILTAISETGL
QLYKLGKTTSMPTWKDNWKPDSFTEIIKQNQSIGAHTLLLIDIALDLEKAKSQLKESLEK
NKIEVEKIILCSNLGVKSRIYYDNLENLPLRIPKPYCMIIPGKLHFHEQDFLEHL
>A0A832YR50|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDEKDMTLKTLEYAKRADKIYAEFYTAALTGTTLNKIEEVIGKKITLLSRE
DVECRSDKLIEESRNKTVMFLTAGDPMVATTHV
>A0A7C5JW06|diphthine synthase|EC 2.1.1.98|Thermococcus litoralis|TrEMBL
MAIYFIGLGLYDEKDITLKGLKIARKCDLVFAEFYTSLLAGTDIGKIEEQIGKPIRLLNR
EDVELNFERIVLSEAKTKDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
AITGLQIYKFGKSATV
>A0A1I6GIA4|diphthine synthase|EC 2.1.1.98|Halogeometricum rufum|TrEMBL
MLTFVGLGLYDERSITVEGRDALADADRAFAEFYTSHLVGATVADLEAYHDVEIEVRDRA
GVEQHPEEILDAAADDHVVFLTAGDTMISTTHVDLRLRAVERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVTDSIEANRERGLHTLVYLDIKADREEYMSA
DYAAEMLAEGWRDVLGVAVARAGSENPVVVADRLSALADREFGDPLHMLVIPGDVHHVEA
DALRTLGGAPDDVVAESEV
>A0A5E4JLJ3|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGLGLNEKGITLEGKEAIKKCDKIYLEGYTVDFPYSIPKLEGFIDKKIVKLGRGDV
ESNKLVNESKKHNVALLVYGCPLFATTHISLLMDMEKAEIKTKIIYSASVFDAVAESGLQ
LYKFGKISSMPRWQKNFEPDSFLEFVSQNKSIGAHSLILIDIGLDFDSALDQLEKALESR
NIKINKLFVCSSIGTSKSKMIYGKIEDLRIKGGKIDLPYCFIIPGEMHFLEKDAIEKFSI
>A0A832NIF5|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLRLVGLGLGPPDYLTLKALSALESSRIVYLDTYTSSVPSELVKFLAGRLGTRLRLAERR
NLEEGVGAILDEASVGDVSIAVPGDPMIATTHVAVLQEAVKRGVDFEVIHGVSALSAAIS
TSHLSSYRFGRIVTIPRQASAESLSTIYRRIAENLQAGLHTLVLLDVAGSGMLASEACAE
LLKVAEKEGGPLYADSPVIVLARIGYPDAFRAVCRLSEAPRLNLPPPPHVLVIPSQLQPY
EAEALEKLLRAPSDLVFSAKRIPTRWGRVERYVEKTARALEGLTVRDSSGEVERALETAR
SYIEDAKYFVERERVDDAMLAISYAEGILDCLKILGKVEFSW
>A0A2R6G4Y3|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_3_64_16|TrEMBL
MLTFVGLGLYDECSITIEGRDAIDSADRVFAEFYTSYLAGTTVADLEAFHDVEIEVRDRA
GTERDPVPVLDAAREDRTAFLVGGDPMISTTHVDLRLRAHEERIDTRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFAYGSGGVPESVLGVIAGNRERGLHTLCYLDIEAEREAYMSAAD
AASRLADALEDSDGNDTGDASSETLAVGIARAGSSEPLVRADRLSMLASTDFGDPLHLLV
IPGDLHHLEAEALETLAGAPTDLL
>A0A7K4D3R9|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLIFIGLGLYDEKDISVKGLEAVRAADKVYAEFYTSRLMGTSVERMEAFYGRKIHLLGRS
DVEDDPAWLEEARDDDVAFLVGGDAMVSTTHLDLRLRAAELGIMTRVIHSASIVTAVQGL
CGLQNYRFGRSTTIPFPYTSRGKRIIPETPYLVLKENLDRNLHTMLFLDIQSAPKERYMT
VNEGAALLLEMQANAREQILDGCLAIGIARAGSEDAAVKADLLVRLKNCDFGGPLHIIVV
PAKLHFMEAKALVALAGAPPDLAVEG
>A0A843JNV0|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosum sp|TrEMBL
MLYLIGLGLSERDLSLRAFELLRKIVNIYVDTYTNYFDFDLLWLENELNKKIIPLSRNDM
EKNPTFLDIAKSKEVALLVSGDPLVATTHTDIILRANKMGVKTKIYHASSIYSAIAETGL
HIYRFGKTTSIPYPEENFFPKSFYDVIVQNKERNLHTMLLLDVKKEKNLFMNPKEAISIL
KEIDKNNNITDIIVISRISHENQKIIYGDIDKLIKFENEYYGPPPHTLVVPAKLHFAEEE
YLLSLAEIHKNSKNK
>A0A7C7KTY0|diphthine synthase|EC 2.1.1.98|Aigarchaeota archaeon|TrEMBL
VCIAVPGDPFIATTHVALREEARKLKVGEEIVFGVSAYTSAISLSGLHVYKFGKSASIPL
TDDINQVRQSYYTLLENQSRGLHTLFFLDTKDGGLRAGKALELLLKVENEEGRGVVRSGT
LVIVVARIGYDDATITAGRLENLINHTLPPPPHMLIFPGELHFTEKEVIKFYALNADDVE
RHAPVNYIRDRVLKYVEKTRRVLQEVRGQDVGEEFCNYVEAYVDDSKNFLTSGDYVNSLL
AIGYAEGLLDALRLLGVVRFEW
>A0A842TSI0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYFIGLGLNNEKDITLKGLEAIKSCNKIYLESYTSKLQCSKESLEKLYGKDIILADRD
MVEKQAESTILKDAKTQDTAFLVIGDPFGATTHTDLMLRAKELKIETKVINNTSILNAIG
IMGLELYKFGRTVSIPFDEKANSFYDFFKKNQSIGLHTLFLLDLNPINNRFLTIKEAIQR
LLKLGLKEDQLCIACSALGSEKKEIIARTAEQIKDIELKHTPQCLIIPGNLHFVEEDALK
QWQ
>A0A662F6K7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGLGASPLEDISVRGLKCVKKAKSVYIETYTCPMQATIAEMESCFGKTIKELSRG
ELEETNKLIGEAKRQDTALLVVGDPLFATTHIELIMRAEKAGVKCEVIHNASVLDYVLDT
GLQGYKFGRIVSLPHPTPELVESPYRYILENKRIGLHTLLLLDVAREQQGIMTIPKAIEI
LFEMENRFKGGVIKEEEKWVGCSGLGTKNKIIKFARPEKLKNLDFKHPPYCIVIPGRLHF
IEEEALNRFA
>A0A832TDI4|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALYLIGLGLHDEKDITVRGLEIVRRVKAVYLENYTSVLSCSVERLEDFYGRKVVVLDRD
AVEKGPDEMLDQALDGDVAFLVVGDPMGATTHIDLVLRAHEKGVKVEFINNASVLTAIGV
VGLELYKYGKTTSIVFPQEGWVVDTPYDVIRQNQEHGLHTLCLLDIKVSEPSKEALRKGG
SVTASDPRFMTVNQAIQALLDIESRRGEKVFTDETLCIGCARLGSPEPFIRVGKAKDLLG
VDFGAPLHSLIVPGKLHFMEEDALRLHK
>A0A8J8DMX4|diphthine synthase|EC 2.1.1.98|Thermococcus sp. MV5|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIAKKCELLFAEFYTSLLAGTTIEKIEQQIGKPIRVLNR
EDVELNFEKIVLKEAKEKNVAFLTAGDPMVATTHADLRIRAKQMGIESYIIHAPSIYSAI
SITGLHIYKFGKSATVAYPEKNWFPTSHYDVLKENKKRGLHTLLFLDIKADQGRYMTANE
AMHILLQIEEMKKEEVFTENTLAIVLARAGSLTPTLKAGYVKEMIKEDFGKQPHVLIVPG
KLHIVEAEYLVEFANAPKEILKEV
>A0A075I2N1|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_10_H08|TrEMBL
MLTECLDKPSDNSDKIKSVSVQMIEKYVPMVRKALEEIRPLYNDSKEFQEVFENAKLYID
DAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKM
>A0A7J3D9X5|diphthine synthase|EC 2.1.1.98|Methanomicrobia archaeon|TrEMBL
MGELIFVGLGLAGSDNMTIEALEAIKKSDIVFAEFYTSKLVDFDVEDLEKKIGKKIIILT
REEVESGKGVIDAARQHCVSFLTAGDPMTATTHLDLRLRASDAGINTRLIHGVSIYTACA
SAFGLQHYKFGRTVTLPFQEKNYHPSSPYEHLLENKKIGLHTLILLDIRASEGKYMTAAD
GVKWLLNMEERIGKGLIDERSLLCAAARVGSRTEKIIAGYPQKILNEDMGPPLHTLIMPG
KLHFMEARALVEFAGAPKEILDHL
>A0A842PID8|diphthine synthase|EC 2.1.1.98|Methanomicrobia archaeon|TrEMBL
MLTFVGLGLYDEKDVTLKGLEAIRDADVVYAEFYTAPLGGKTVERMEMAYGKRISVLERG
DIEENAEETILKLAKNQKVVLLSGGDAMIATTHVDLRLRAIDMAIDTRIIHAPSISSAVA
GLCGLQSYKFGKSATVAPPYKGLISEVPYDTVMANKERGLHTLLYLDISMRIKDALKLLE
TVEGKRKGEVLKESVIVGIARAGSDMPVVKADYLGALKSYEFGELPHVIVVPGDLHFLEK
EALVKIAQAPASI
>A0A2R6GZP1|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_6_64_34|TrEMBL
MLTFVGLGLYDERSVTIEGRDAIGDADRVFAEFYTSRLVGTDLDRLETFHGTDIEVRDRA
GIEREPEPILEAAQSADVVFLTAGDTMVSTTHTDLRIRAEERGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEKAHGGEGVPDSVVSTIEGNRERDCHTLVYLDIKVDDPHWADG
DDTYMTADTAAELLSVEFPDQLAVVVARAGSPDPLVVADTLEELAGRDFGSPLHLLVIPG
ELHPIEDEALAAVADS
>A0A075HDG1|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_55_G04|TrEMBL
AISVLTECLDKPLDNSDRIKSISVQMIERYVPMVRKALEEIRPLYNNSEEFQEVFENAKL
YINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIEPKM
>F0LHG9|diphthine synthase|EC 2.1.1.98|Thermococcus barophilus (strain DSM 11836 / MP)|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLIFAEFYTSLLAGAKIEKIEKLIGKPIRVLNR
EEVELHFERIVLSEAKNRDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
SITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKADQGRYMTANE
AMDILLQVEEMKRQNVFTPETFVVVLARAGSLNPTLKAGYVEDMIKEDFGKQPHIMVVPG
RLHIVEKEYLVAFADAPEEILRRRDL
>A0A7J2XAB5|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
NKKIGLHTLVLLDIQADKNRYMTAKEGMMLLLEMEKINKENILSEESIACVVARAGSDDS
FVKADSIRNLIRMDFGPPLHSIVIPGKLHFMEIEALLVLAQLPAHLGEKLQKI
>A0A7J4IQ23|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MTETSLPAGLWLVGLGPGNLDYMSKYANDITKSCSKRYLEGYTAILPPKQEEKLESLIGK
WERMMRPDIENPEKLLKMAKEIPVALLIVGDPMQATTHIDLEARCEEMGINFNVVPGITA
TALAVSLSGLQSYRFGRQVTIPFSYGEYLPHSPLEMICKNYENNLHTLVLLDLDPTGMGV
NNPKPMKPDEAISLLARMAGKILEETSTFEILKKPVDEWDGILLTDISMVEQKVTAGNLS
QLSKLKEGWIHCMIIPSNMNDNELEAFERRKNC
>A0A544QKU2|diphthine synthase|EC 2.1.1.98|Halonotius roseus|TrEMBL
MLTFIGLGLYDEHSITREGEAALQAADRVFAEFYTSRLLGADVADLEAHHDTEIEVRDRA
GVEQNPEPILQAAENGDAAFLTAGDTMISTTHADLRVRAADRGIDTRVIHGVTAETAASG
VTGLQNYRFGKAVTLPFPGLHGAGNVPPSVIESIDANRERGLHTLVYLDIKVDSHRDLSA
LDTDDPYMRADHAAELLAADWHDELAVVVARAGGPDPVVAADRLSALAERSFGEPLHLLV
IPGDLHHVEADALEALAGAPTALLPDEA
>F7XKM6|diphthine synthase|EC 2.1.1.98|Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5)|TrEMBL
MLTFVGLGLFDEKDISLKGLDAIKNADRVYAEFYTSCLIGTSIEKMERLYSTRIHLLSRE
DIENNPEWLESAMHEDIVFLTGGDTMVSTTHVDLRIRAHDMGIDTKLIHGASISSAACGL
SGLQNYRFGKAATVPYPYISSRGKEVISHTPYDTIRANTIAGLHTMVFLDIDVEKGFMKI
PDALEVLLQVEKSRNEGVMKNRLVIGIARAGSEIPAVKCDFAEKLLDFDFGHPLHILLVP
ASLHFVEAEALVKLAGAPEEILESIEK
>A0A497GST0|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGELIFIGMGLYSEKSITLEGIEVAMECDEVYVELYTSVMPGLRLDSLEKLLRRKIRVLT
RKELEDGMYEIIDKARKRRIALMVPGDPFMATTHQIIRVEAEKRGVKTRIINGVSIFTAI
PGLTGLHSYKFGRSVTLVHPVDGVKPYTVYEVVKSNLKMGLHSIILLDIKVEEGIFMTIP
EAVRILQDMEEELQEGIFTPNRLVIGIARAGAPDFVVKADALSKLKHYDFGPPPHTLVVP
SEKLHFTEAEALYVLAKAPQELLRGVKGWRR
>A0A7C4X1C0|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MNYLLRVMRCWSRMKGKLYIIGAGISLDYLTIKALKILRNVKNVFLDGYTGVLLGDGSRL
AEIIGGREYKVLSRRDLEDLNGELIFKALEEGDVALVSPGDALIATTHVNLMIEARRRGY
DVEVVPGVSIISASISVSGLMAYKLGKVSTITYPKEGVVYEYFYDVIKENSARNLHTLLL
LELDVERGVFMTIRDAIQILFDIERSRGEGVISPNRLAVGISRLGDVEMKVCPDELGKLI
NIDFGKPPHTLIITSPKLHFIEKDALEVVKDVYCR
>A0A7C3LRP3|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MNLGGGLILVGAGLSTDLITLRGVKRISEADVIYVDSYTSVTLGDLRGFIKSQTGKEVLL
LKREDIEERYFEVLIRPALEGRKVVLVVPGNPLDATTHVALLSEASKRGVEFEVVPAPGI
IPNALTMSGLMIYKMGKIATLTYPKSGILSEYPYDVIKDNDLRNLHTPLLTEIDLEKGIK
MQVREAVEILLLLESKRGEGIISEARKAIGVSGLGWDKQRICFGALKDLAKLPDHEGPHT
LIITSPKMHFLEEEVAQIISKKYCHEIT
>A0A7J3I814|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MLRLIGLGLSIYLLPIGNLVKLLRCNKILVDTYTSIWFSEGIDLFKMLNMDGIEVVYACR
NDLEGKGIDVVVEEARSKDICIATPGDPLIATTHSAIVVEALRKGVPVEVSPSSSILNVG
ISMSCLQVYRFGRIATVVRPKNGIEYEHPLHIVKLNRVQDLHTMLLLEMDAENNYFMTPR
EAIEVLLNIQRRWGEEVIALDDVIIVQQAITSGKGRVYVETVNRIVDSVTEFGEPPYTVI
IPARKLHPIERECLDNIEKIQCYTPSQYTDLHKLLERIHRLK
>A0A8J8CG90|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum hamiconexum|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>A0A7C4H5K3|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MALYILGLGLGSLDYVTLGVLNRLKMCSEVYLDSYTSFISRELLEWLEKELGEKLKIAVR
KNLEDNIDEILEKAVHRNVAILVPGDPFIATTHISIIVKAREKKVDYEILHGVSAYSAAP
SITGLHIYKFGRTITLPREGDPKEVYRVIQDNMEKGLHTLILLDTADGGLTIPEALIKLL
SVEESLGRKILNEDSLAIALVSLGMSNQLIKVGTIRELLSVEYPPPPHMLIFPGELHFTE
IEILIKIHGAREDIVRKYRPPRYEKDRTLNYITKTRRVLKELKINEDSKHVKDVLEIAES
YVEDSYSYWSSGEIYNALATIAYAEGLLDGLRIVGKISFKW
>A0A842ZQV0|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MVKGRLVFVGLGLYDEADVSLKGLRELKQCDEVFAEFYTTKLGQFDKKAFEKLIGKKIEV
LSREETEKGDRIIDAAVQNHVVFLTGGDPMIATTHVDLRLRAMKQGITTKIIHSSSIVTA
VPGLLGLQNYKFGRTTTLAFGEKEYFPTSPYTVIYNNKEMGLHTLVLLDIQVEKNRYMTA
NEGLELLLKMEDTLRKCLFTDDTIACVVARAGAPDPVVAANTINVLRKKDFGPPLHTLVI
PGNLHFMEVEALELCAGLPPEVGKKIQKL
>A0A7K4NFD2|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKTSKSSTVVLLSYGDPYVATTHIELRTRAKLENIETSTIHSASAITSMTGE
AGLQFYKVGRMVTIMNEKKSTITPYTAIFKNLTQGLHSIILLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVVNNDTFAIVASRIGFKTQKITSGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSTRIKSTSVQMIEKYVPMVRKALEEIRPLYNDTKEFQEVFE
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKI
>A0A7K4M909|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGFKSIPSEGLDILSKADIVYLEQFTSPIEKSDFDKIKNITKGEFKPAKRW
LVEDGNEILQNAKKKKVVLLSYGDPYIATTHIELRTRAIKEKIKTYSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYLIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALNG
LLETEKGQRRNVISLSTYVIVASRIGFKDQSIISGKISSLKKKDFGKPPHTIIIPGRLHF
TESDALKILVECIDDPFDNSEKTKKISIQMIEKYVPMVKEALGEVEHHYKDQKEFQKILE
NAELYIQDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLKRKM
>A0A8J7XPZ2|diphthine synthase|EC 2.1.1.98|Theionarchaea archaeon|TrEMBL
MLYLIGLGLNGDLTREGVTTVQKCKVYLELYTSFLTVPLKDLERVLQKDITVLTREDIEE
TQQFLKEAKTTDVALLVVGDPLVATTHAEIIIEARKRAITTKVIHNSSVYSAVAETGLQI
YKFGKAITIPFSQEGFQPTSFYEILQKNRIIGAHTLVLLDIQHDQKRYMNPKEAMEILHR
LGFQEEVICVSRLGCTDQRIVYGEIENLLKLDKQYWGSPPHCLVIPSSLHFKEEEFLEQF
RLKVIK
>A0A842KMS7|diphthine synthase|EC 2.1.1.98|Methanomethylovorans sp|TrEMBL
MLTFVGLGLFDEKDISLKGLEAVSMANRIYAEFYTSRLMGTTLEKMEKLYNKKIEVLSRE
EVEQCPYWLEYAKNENVVFLTGGDTMVSTTHVDLRLRAIDMGITTKLVHGSSISSAVCGL
TGLQNYRFGKAVTVPHPYISGRGKTVISETPYETIIQNLEHGLHTLVFLDIDSKKGYMTV
NQALHILLQVEANRNTKILRNRLAVGIARAGSDLPTVAADYAEKLIDFDFGSPLHILVIP
ADLHFIEAEALVKLAHAPVSILKVDE
>A0A1G0A8F4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon RBG_19FT_COMBO_69_17|TrEMBL
MGELRFIGLGLHDEKGITIRGLEEARACDVLFAEFYTSALVGMGPRGLEALLGKEVRVLR
REQVEAGDAILEAARDRRVALLVAGDPMAATTHVDLRLRAAAQGIGTRIVHGVSILTAAA
GALGLQSYKFGRTTTVPFPAPGFDPTSPLEGILANLRAGLHTLVLLDLRDDGTSLDPKDA
LRRLLEAADRARAYELGPTTLACVLSRVGSPDGRAAADRVEDLLERDLGPPLHCLVVPGS
LHFLEKEALVAFAGAPQDV
>A0A8D5AG67|diphthine synthase|EC 2.1.1.98|Methanoculleus chikugoensis|TrEMBL
MLTFVGLGLFDLGDISVKGLEYVRSADAVFLEAYTSRLMGTDVGAMEAFFGKEIRVLGRE
DVEQNPRDILDRAAAGRVAFLTGGDPMVSTTHADLRLRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPIETIAANLAQNLHTLVYLDIQKDRYMRVPEAIA
VLEEMAEKRGIEPPALYVGIARAGSDRPVVAAGTGATLKETDFGPPLHILAVPAELHPME
REYLEIFAGL
>A0A662RYD2|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLIFVGLGVWDEKDISLRGLEAVRNADIVFAEFYTSPLAGRRTERMEKIYGRKIIVLKRE
DIEENDFILEHAKEKNVVLLSAGDPMIATTHVDLMLRAVEKGIKTEIIHASSVYSAVAGA
CGLQIYKFGRSATVSPPFRDVISEVPYETVIENRKRGLHTLLFLDIDMSIGYALNLLEEI
ERRRMSSEMDAEMDAEMDDELVKSGDGNEDDCDMRAGGMIGGISDVLFVGIARVGASDQV
VKADYIDALRTYDFGDPPHILVAVGNLHFMEKEALIKLADAPLL
>M0EIB8|diphthine synthase|EC 2.1.1.98|Halorubrum distributum JCM 9100|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKSTTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A2I0PQT1|diphthine synthase|EC 2.1.1.98|Methanobacteriales archaeon HGW-Methanobacteriales-1|TrEMBL
MPLKGDSMLYFIGLGLYDEKDVSVKGLEALKSADEVYAEFYTAGLFGTSISAFEKLLERE
VKILTREEVEEEIIPIKAAESKNIAFLIAGDPLIATTHTDMMMEAKKRGIETQVIHSSSI
LSAAPGISGLQAYKFGKVTTVPFTEENFFPHSPYLAIKNNMEQDAHTLVLLDIRAHENRY
MTVNQGLKYLMKVENDRQEGVLGDDTLVVAIVRAGSPQPLVRADKIKNLIKEDFGGPLHC
LIIPSKMHFMEAEYLVAMAGAPEEIL
>A0A1Q7BAQ4|diphthine synthase|EC 2.1.1.98|archaeon 13_2_20CM_2_52_21|TrEMBL
MSLTFIGLGLNDERGITLEGLEEARRADAAYAEFYTNLMPNLDLRRLEQEIGKKVEVLSR
TQLEDEGGQELLRAASKERVVFLVPGDPMIATTHVSLRLSLARMGIASRVVHAPSVVSAV
CGATGLQSYKFGKSITVPRDQPFPRSVLETISDNNDRGLHTLILLDVQAGETSQMTIRDA
LAKMTVADHRLETRLAVGVARLGSRDEKVKASRMKTLTNEDFGKGPHSIIVVGRLHFMEA
EALKLLCGADAKDLSELT
>A0A257A4X7|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon ex4484_178|TrEMBL
MLTFIGLGLYDEKDVSIRGYEAIKDADVIFAEFYTSQLMGASIEKLQEFYGKEITLLSRE
EVEEGRRIIEKAENKKVVLIVPGDAMIATTHVALRIMAEERGIETRIIHGASIVTAVSGL
LGLQHYKFGRTVSIPFPQENYFPTSPYDAIMENFERGLHTLILLDLNPRPMRANEAMEIL
LKMEEKKGLGLFNEKTLIAVVARAGSPDRVLRAGYMGELIKENFGPPLHSLVLPGKLHFT
EAEALVRLAGAPKEILEE
>A0A7C5SYW3|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MPWLAFVGLGLKLKDITLEALETLRNANTIFLDTYTSISPDINVSSLRRLVGKEVIPLRR
RDIEDENAEKIFNELSRGRNVAFAVIGDPFIATTHVALLLEAIRRNVEVKVIHGLTIYTV
AISYSGLMVYKFGRCATIVYPKEGIFYDYFYDVVKENLKLGLHTLLLLELDVDNNVFMTA
NDALKLMLEAEGKRKEGIISKDMKVLVIARAGFPTQKYVYGKIASLIRENFGPPPHTIIV
PGKLHYIEEDALKRFLIN
>A0A2K3JAG6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon M8B2D|TrEMBL
MSNKLIFIGLGLYDEKDISIKALEEIKKYNKIFAEFYTSKLVGTNFKKIEKIIGKKVEIL
SREETEKGDKILKAAKTQNVSFLTAGDPMTATTHVDLRIRAIKNGIKTKVIHGSSIVTAV
PGLLGLQSYKFGRITTLAYPEWDYFPTSPYDIIFDNKKMGLHTLVLLDIQEDKKRYMTAN
EGLKIILDMEEKVGKKMFNSNSVVCVVARAGSEKPLVKAGTFKKLLDFNFGPPLHSIVVP
GRLHFMEVEALMTLAQLPAHLGEKLQKI
>A0A7C7PHR4|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTHVTRHSEQSRSLDADGGPPMREVTPGLWLVGIGPGDIDSMSLEAVEVARGCDHRFLEG
YTALLPPAQEELLAERVGEWTRLMRPAVENPDELLELARTSAVALLVVGDPLQATTHVDL
QLRARERGISCEVVHGISITTIVTGALGLQSYRFGRQVTLAYPYGDYLPTSPLELVLANR
QQNLHSLMLLDLDPSGMGEAEQQPMSPADAMAVLGRAAEKIGVDIEGWTMVLCSDMGTSE
QRIVCGTPEQISSVEGGRIHCLVIPGSLDELEELALERWRA
>B7R444|diphthine synthase|EC 2.1.1.98|Thermococcus sp. AM4|TrEMBL
MALYFIGLGLYDERDITLKGLEIARKCDKVFAEFYTSLLAGTTMEGIEELIGKPIIRLSR
EDVELNFERIVLPEAKEKNVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENRERGLHTLLFLDIKAEQNRYMTANE
AMEILLRVEERKGEGVFTPETLVVVLARAGSLNPTIRAGYVGDMIHEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPAEILEEV
>A0A367I4Z6|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MDTSGLFLIGLGPGDLGLMSQRAINLLQDMDERYLEGYTATLPIDQESELENLVGPWKRV
MRPKIENPREIIEEAKTRKVAIMVVGDPMQATTHVDLLLRAKENGVRVTIVPGISATTLA
ISSSGMQSYRFGRQVTLPYAYGDYLPTSPLRYILDNRSRNLHTLVLLDLDPTGLGIEDPI
HMSPPVAGQILMQMAERWNEENEEVDVSTWNVVVLSDLGTAQSHVCSTIIEEMEGMDKGR
IHCLILPAEMDNHELMVFDSMRYHA
>A0A2A5NXZ6|diphthine synthase|EC 2.1.1.98|Candidatus Geothermarchaeota archaeon ex4572_27|TrEMBL
MTLYFVGMGLHDHHDLTLKGLKVARSCDKVYVDLYTSLMAGLKVEDLEGLLGRRVTVLSR
SDLEGRKAVEIVEEASRLNVALLVPGDPFIATTHVALRIEAKRRGVEVKVIHGASIASAA
PGLTGLSFYKFGRPVTVVYPEPGYMPEAPYDVLRDNASRGLHTLMLLDIKAERGAYMTVP
EALRLLMDIEGRRGEGVVDGDMLVVGVARAGSMEPSIAAGGLMRVLEADLGPPPHTLMVP
GELHFVEEEALVSICGARREEVEAHKRWLRRLRSRAREAP
>A0A832XL23|diphthine synthase|EC 2.1.1.98|Candidatus Naiadarchaeales archaeon SRR2090159.bin1288|TrEMBL
MIKIIGLGLWNEKSMSIEAMEEANDCDVLYAEFYTSRLIGLRSKEELVKVLGKDIKFLRR
EEVEVSQKFILDRAKKEKVGFLVAGDALTATTHIDLVIEAKKRGIEVKIIHGSSIYTAAA
GLAGLQIYKFGRSCSIPYPQPGFKVESPFEVIAGNLKQGLHTLVFLDIQPDKLMTANEAM
QILLEIGKKKKSRILDNKEIVVVARAGSDEAVVKYGKIKDLIEMNFGEPMHIIIVPGKLH
FKEKEYLEFCR
>V5TN06|diphthine synthase|EC 2.1.1.98|Haloarcula hispanica N601|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A257MLY0|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. ASO1|TrEMBL
MLTFIGLGLYDEKDISIKGREAIAAADRVYAEFYTSRLMGASLSRLEEFHGRKIHLLSRS
QVEVEPSWLEQAKDEDVVFLVGGDAMVSTTHLDLRLRAMLMGIKTRLIHSSSIVTAVSGL
SGLQNYRFGRSTTIPFPYLARGKRIVPETPYRVLQENLARNLHTMLFLDIQRDPVERYMT
AGQGAALLLEMESEAEDKLPPGTLGIGIARAGSDDAVIRADRLSRLKDCDLGGPLHILVV
PARLHFMEAEALRVLAAAPEDALMGAD
>A0A497SMV4|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYFISLGLHDEKDMSLKALETARACDLLFAEFYTTKLETTKEKLEQLIGKPIKLLSRKD
LEENYQAILEEAKDKKVGLLVGGDAFVATTHVALRLEAMKQGIETRVIHGSSIISAIGET
GLHVYKFGASITIPFLEKTKGKLPESVYEVIKMNKARGLHTLCLLDIVAEANKLMKINEG
IKILLEIEAKRKEGVISLEDEIVVFARAGSEKPLLAFGKVKDVLE
>L9WUC3|diphthine synthase|EC 2.1.1.98|Natronorubrum bangense JCM 10635|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSKLIGTTVDDLESHHGVDIEVRDRA
GVEQHPDDILAAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTRTIDDNREDGLHTGVYLDIKVDNEAATNR
LEGDETVEEYMTADVGAALLAEEYPDLVGVVVARAGSPDPLVEADTMAALAEREFGDPLH
LLVVPGDCHLLEADALVELAGVDRDDLDIV
>A0A3R7VWA6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED117|TrEMBL
MVDDKKSGLALIGIGPGKVSSMTLEAVELARQADVRLYEAYTALWSEEALLELESEIGSI
QRVMRPTIXQPEDLLEMARTQYVAVLVVGDPMQATTHIDLQLRAESAGXPVRXVHGISIT
TLVPGATGVSNXKFGRSTTLTYPYGDWIATSPLEVMXQNYSQKLHTLVLXDLDPSGAGTG
DQLPMQSSDAAESIAKMVAKYKXMELTPEQTEIVXXINSLEVVLCSDLGTDDQRLQTTTX
ENLGTKSSGRLNCMVLLANXSEIEREAVNRWK
>M0I655|diphthine synthase|EC 2.1.1.98|Haloferax alexandrinus JCM 10717|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A1V4UUE2|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaB.Bin018|TrEMBL
MLIFIGLGLYDEKDISVKGLEAVRAADNVYAEFYTSRLMGTSVERMEAFYGRKIHLLDRS
DVENDPVWLEEARDGDVAFLVGGDAMVSTTHLDLRLRAAKLGIRTRVIHSASIVTAVQGL
CGLQNYRFGRSTTIPFPYTSRGKRIIPETPYQVLKENLNRNLHTMLFLDIQSDPLERYMT
VNEGAALLLEMQANASEQILDGRLAIGIARAGSEDATVKADLLVRLKNFDFGGPLHIIVV
PAKLHFMEALALVTLAGAPPNLAVEG
>A0A842KSF5|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
MLYIIGLGLYDENDISIKGMKTLKECDRIFAEFYTAKLKDQSLSTIKEKTGKDIQIIGRK
EIEEEMKPLKYAKREDVALLVPGDPLAATTHSTLILEAQRKNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEENYFPHSPYLTIKNNLKYDAHTLILLDIKAEENKYMNANQGL
KYLL
>A0A842M3Q8|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
YLTIKDNLEYNAHTLILLDIKAEENRYMSANEGLEYLLRVEKERRENIIDLNTLAVVLAR
VGSSDPLIRADLIKRLIVEDFGRPLHCLIIPSTLHFLEAEYLIEIGGAPPDILK
>A0A832YVQ0|diphthine synthase|EC 2.1.1.98|Archaeoglobus profundus|TrEMBL
MLIFVGLGLWDEKDMSYKGLEIAKSADEVYVEFYTSKLMGSSLDRLQKFIGKEVKILERS
DLEENSEWLIQRAKERDIVILTPGDPMIATTHSALRLEAEKRGIKTKIIHSSSIMCAVCG
LTGLHSYRFGKSATVCYPYKGIIPKTPLNVIKQNLSIDAHTLLYLDLHPKPMTIREAIDI
LMKADDDNILIDLFAVGIARAGSDNPFVKCDKLLNLRKVNFGSPLHVLVVLAKTLHFTEY
EYLRMFASAPEELKEIVV
>A0A7C4QL42|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MNLGGGLILVGAGLSTDLXTLRGVKRISEADVIYVDSYTSVTLGDLRGFIKSQTGKEVLL
LKREDIEERYFEVLIRPALEGRKVVLVVPGNPLDATTHVALLSEASKRGVEFEVVPAPGI
IPNALTMSGLMIYKMGKIATLTYPKSGILSEYPYDVIKDNDLRNLHTPLLTEIDLEKGIK
MQVREAVEILLLLESKRGEGIISEARKAIGVSGLGWDKQRICFGALKDLAKLPDHEGPHT
LIITSPKMHFLEEEVAQIISKKYCHEIT
>A0A368PEM0|diphthine synthase|EC 2.1.1.98|ANME-2 cluster archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGVRAIKDADMVFAEFYTSKMMGTTIERMESRYQTKITTLSRG
EIEADPAWLHHAIDQDVVLLSGGDPMVSTTHIDLRLRASDLGIATVVVHGTSIASAAAGL
AGLQNYRFGKSATIPFPYTVRSKTVVSETPYNTVLLNRDNDLHTMLFLDIDPEKGFMTIS
EAAQLLMQVDERGLLDRALGIGIARAGSPDVVVKCDYIRNLAGSDFGAPMHLLIVPAGLH
QMEAEALVRFAGAPDEIIER
>A0A1F2PA03|diphthine synthase|EC 2.1.1.98|Candidatus Syntrophoarchaeum caldarius|TrEMBL
MLTFVGLGLYSAKDITVRGFEAVKSADIVYFEEYTSSLGGCDRLTLEEVFGRKIYPLSRE
EIENEPEKILLHATSYNVLLLTGGDPMIATTHVDLRLRAYDRGIRTNIIHAPSIFTVVPG
ITGLSSYKFGKTATISFPYRDKAESISDLPYDTIKQNRSHGLHTLLLLDITHERQMTIKD
ALEILETLETRHGEGLMKDLIFVGIARAGSEDMVVKAGGMKTLMEFDFGTPLHVLVAVGD
LHFMEEEALCKFAGLERDL
>A0A7J3G545|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
AVENEIALLTPGDPFIATTHLSIRTIAHRKNVAVKVVHGVSAVSAAVSSSGLHVYKFGKT
ATIPKTTDSNMLHEVFKTIETNLSNNLHTLLLLDTSDQGLTVPEAVKQLLDYSKQHGKSF
INQNTLMVALARLGFPDNVTLAAPAEKLISHNFPPPPHSIIIPSSLHFTEEEILQTFHKG
PLNTAENPLKSRVMNYVSKCRRIIAELSRVHEQTDYLGYVSRYVEDAERFIRDGKMADAL
LAIGYAEGLLDALRLRGEVRFTW
>M9U8Y6|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus LAL14/1|TrEMBL
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSERAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>A0A838U4S2|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLYLIGVGINEYDSLSSGSIEILKHSNIVYIERFTGFLSNEFIVKIKSLLSSMDNSDEIN
KIEIQLVKRWFLEDGKKILENSVKKTVCILVYGDPLIATTYNELLVRASKQSIPYKIIHS
SSGISSLIGESGLHYYKFGKMVTMMSDPMSTITVYDTIYNNICLGLHTLILTEYNNDDGK
NDFNSNNDNPFFLSPKKVFDLLMERENELKLLNLSENSFVIVACKIGTDNSKIIGGKIKS
LINFQFESGPHSVIIPGVLHFTEIDSLKNLTIIFDDPIDNSIAVDKLSNRMLNKYIPNAK
KALAKLSYLIHEEKNIAKNEYSVVLENAENYLLDAEHFYKQGKLELAILSVGYAEGLIDS
LRFQKGMNPW
>A0A838YLC4|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPNEALDILSKADIIYLEQFTSPIGKSDLVKIKNATKGEFEPAKRW
LVEDGNEILQNAKKKKVVLLSYGDPYIATTHIELRTRAIKEKIKTFSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYLIYKNVIEGNHTILLLEYNQDKDFFLDPKDALNG
LLETEEGQRRNVISLSTYAIVASRIGFKDQTIISGKISSLKKRDFAKPPHTVIIPGRLHF
TESDALKILGECIDEPFDNSEKTKKISVQMMKKYVPMVREALEEIKPYYKDQKEYQVILE
NAELYILDAEKFLEDGQDEVAILSIGYADGLVDALRLTKGLDPKM
>A0A6G2KHD9|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0677_bin_16|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A2Z2MMC4|diphthine synthase|EC 2.1.1.98|Thermococcus siculi|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTTIDKIEEMIGKPVRRLSR
EDVELNFERIVLSEARDRDVAFLTAGDPMVATTHSDLRIRAKQAGIESYVIHAPSIYSAI
AITGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENMERNLHTMLFLDIKADQNRYMTANE
AMEILLQVEEMKGQGVFTPDTLVVVLARAGSLNPTLRAGYVRDMINEDFGRQPHVMVVPG
KLHIVEAEYLVAFAGAPEEILEET
>A0A832LID0|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp|TrEMBL
MLYIIGLGLYDEDDISIKGMKALKKCERIFAEFYTAKLKNQSLSSIKKELGKEIKVLGRK
EIEEKMIPLKNAQKWNVAFLVPGDPLVATTHSNLILEAKKNNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEKNYFPHSPYLTIKDNMKYNAHSLILLDIKADENRYMSANEGL
EYLLKIEKERQENIICEDSLAVVVARAGSQDPLVRADRIKTLIGEDFGKPLHCIIIPSKL
HFLEAEYLTKIGGAPPEIMEEENETP
>A0A832PFH5|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp|TrEMBL
MGGRSHMLYIIGLGLYDENDISIKGMKTLKVCDRIFAEFYTAKLKDQSLSTIREETGKDI
QIIGRKEIEEEMTPLEYAQGEDVALLVPGDPLVATTHSTLILEARRKNIKTRIIHSSSIF
SAAPGLAGLQVYKFGKTTTIPFPEENYFPHSPYLTIKDNLEYDAHTLILLDIKAEENKYM
SANEGLEYLLRVEEERGDDIIGLDSLAVVLARVGSSNPLIRADRIKKLRLEDFGGPLHCL
IIPSKLHFLEAEYLVEIGGAPPEILEGER
>A0A0M0BZ78|diphthine synthase|EC 2.1.1.98|miscellaneous Crenarchaeota group-1 archaeon SG8-32-1|TrEMBL
MEKLGLNELVFIGLGLYDEKDLSVRGIEELKDADTIFAEFYTSLMPGFSIQKLEAMIGKQ
VNVISRRVLEEEDGKQLFEATKKGKTVLLVQGDPMIATTHVDLMISAKKQGIKTLVIHGA
SVVSAVRGISGLQNYKFGKSVTIPFFEEGFVSETPYIVIKENKERGLHTMCYLDIQANKK
KYLTINTALKTLLELEKQKKEQVITKKTMVVGVASAGSPKPVVKAGYIKDVIKFDFGAPP
HTLVVVGKLHFMEAEALYVLGDAPKEVLEIAE
>U3T975|diphthine synthase|EC 2.1.1.98|Aeropyrum camini SY1 = JCM 12091|TrEMBL
MDGRRGLVTLLLVGWGYAPGMQTLEALEAVHRADVVYVESYTMPGSDWLYRSVAEAAGDG
RVVRASRSDLEERSSEIVSMAIDRVVAVVTAGDPMVATTHSSLAAEALEAGVRVRYIPGV
SGVQAARGATMLSFYRFGGTVTLPGPWRGVTPLSVARRIYLNLCADLHTTALLDVDDQGV
QLDPSVGVRLLLRGDEEYSSLAGAPALLARLPAILVSAGVGGDHRVLYWSSLGELARAGV
ERGVYSMIVPARLSPVEEWLLAVAAGEQSPLEFDRDVYKIVGENCKKGVYMEPV
>A0A7K4IIN1|diphthine synthase|EC 2.1.1.98|Nitrososphaerales archaeon|TrEMBL
MLFFIGLGLHGAKGLSLLGLDLAKKADIVYLDTYTSPVAKDEVDSLKGLIGDKIIAVGRE
FIEDGREIIHQAGQKDVALVASGDPMVATTHMELRLRAERSDIKTIVVHGPSILCALTGE
TGLHAYNFGRPVTLMRTGAPRSTVYEVIHENLARGIHTALLLEYDQASGFSLDPREALHS
LLEMEADNRQGLIDDDTLLIVASRIGSSSQSISGGNLAGLIHKDYGEPPHLLIIPGRLHF
TEIDALRTLLDIDEGKIRDNSLRAQRLAVAMVRRYLSSTRSALSKAVERGKAEKKHLDDL
FENVECYLSDSERFLNAGKYELAILSVGYAEGLLDSLRLTKELKVEW
>A0A800XMW3|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon Met12|TrEMBL
MPITFVGIGLYDEADITLKGLEAIKNADLVLAEFYTSKLMGTTLDKMERLYGKKIHLLSR
RDVEEGADDILSNVKNQNVVFLTGGDSMISTTHIDLRLRAMEQGIQTRVIHGPSIYSAVC
GLTGLQNYRFGKSATIAFPYKRHVSEYPYDTIKVNKEHNLHTLLFLDIAERYMTINQAIE
LLFRIERRRKEDVLKGVAVGVARAGSESPVVKADYIEHLQKYDFGLPLHTLVIVGGLHFI
EAEALIKLADAPNEIEKEIL
>A0A1V4U0B1|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon PtaB.Bin056|TrEMBL
MLTFIGLGLYDHKDISVRGLECIRSADLVFLEGYTSRLAGTSIAGMQEYYGRPIRVLGRE
EVEQHPEIILDPAMTGDIVFLTAGDPMVSTTHSDLRIRATLRGIKTALIHGASISSAVCG
LTGLQNYRFGKSCSLPFPQKNWTPMTPIEVIRTNLAQGLHTLVYLDIQDDRCMTVPDAVS
LLEEMAQKAGISIPVYVGVARAGSPEPVVLAGTADRVRNADFGPPLHILVIPGPLHVMEE
EYLSLFGGL
>A0A0X1KK08|diphthine synthase|EC 2.1.1.98|Thermococcus guaymasensis DSM 11113|TrEMBL
MALYFIGLGLYDEKDITLKGLETARKCDKIFAEFYTSLLAGTAIDRVEELIGKPIIRLSR
EDVELNFEKIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTLLFLDIKAEQNRYMTANE
AMEILLKVEEMKKEEVFTPETLVVVLARAGSLNPTIRAGYVKDLIEEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEEILEEV
>A0A256ZZ09|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon ex4484_217_2|TrEMBL
MPWLAFVGLGLKLKHLTLEAIEVLKESDIIFLDSYTSVGENISAETLSSFLKKQVIPVSR
RNIEDENGKIIFDALDKGLNVSFAVIGDPFIATTHIALLLQAVKKGIEVKIVHGISIYSV
AISCSGLMSYKFGKSATIVYPKEGITYEYFYDVIKENKKRGLHTLLLLDLDVEKGIFMRA
NEALRLLMEIERKRKEGVILENEKVLVIARASLRDQKCVYGVISELLSKDFGPPPHVIIV
PGKLHFIEEEALRRFTIK
>U1PJE6|diphthine synthase|EC 2.1.1.98|halophilic archaeon J07HX64|TrEMBL
MLGFVGLGLYDERSVTLRGREELRAADRVFAEQYTSILAGASLADLERAHGVEIELRDRT
GVERDPEPILAAAETGQTVFLVGGDPMVSTTHVDLRLRADDRGIETQVVHGTTAQTAASS
LTGLQNYRFGKATTLPFPDTHGGVPGSVLETIGDNRERGLHTLVYLDIDAATDRLMTGDT
AAGLLADHLDCLGVVVAQAGSDDPLVRADRLGTLATESFGPPLHLLVVPGELHPMERDAL
RALDDGSSDALNGD
>A0A497S1N4|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MLYLIGLGIYDERDITLRALEVLRDVESVYAEFYTSASNVNLKNLEELVGKKIHVLSRCD
LEEHPEGNVLKDSSKKETALLTPGDPMVATTHVDIILRARKLGIKTRVIHGSSIYSAVAE
TGLQIYKFGRTTSIPFPEKSYYPTSPYDVLRENLKTGLHTLFLLDIKPEESRFMSVNDAI
RILLRIEEKKKEGIFTEETRCLSAARLGGNSIIRYGRVRDLMDYDFGRPPHVLIVPGKLH
FMEEEMLKTFAHS
>A0A6A9STA4|diphthine synthase|EC 2.1.1.98|Natronomonas sp. CBA1123|TrEMBL
MLTFVGLGLYDERSITVEGREAIRSADRVFAEFYTSKLAGASVQSLESYHDTDIEVRDRP
GVESDPEPIFDAAEDGECVFLTAGDTMISTTHVDLRLRAAERDIETRVVHGTTAEAAAAS
LTGLQNYRFGKATTLPFPYAHGADGVPGSVLDTIADNRERGLHTLVYLDIKVGTGPSGID
PDHEEYMTADYAAELLAEELDCVGCVVARAGSPDPVVAADRLDALADRTFGDPLHLLVIP
GDLHVLEHDALSTLAGAPEESLPDPV
>W0JNK7|diphthine synthase|EC 2.1.1.98|Halostagnicola larsenii XH-48|TrEMBL
MLTFIGLGLYDERSITVEGRDALRDADRVFAEFYTSTLLGTTVEELEDHHDVSIEVRDRA
GVEQRPDDIIEAAETESVAFLTAGDTMISTTHVDLRLRAHDRGIETRIIHGVTAQTATSA
LTGLQNYRFGTATTLPFPYAHGADGLPASVTNTIDANREAGSHTVVYLDIKVDNEAATQR
VEDDEAVAEYMTADVGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMTELAEREFGDPLH
LLVIPGDCHLLEADALVELAGADREALDIV
>A0A6B0Y4D4|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0664_bin_35|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A8J8ED44|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 21S7|TrEMBL
MAIYFIGLGLYDEKDITLKGLEVARKCDLVFAEFYTSLLAGTTLDRVEELIGKPIRRLSR
EEVELHFERIVLSEAREKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKRENVFTPDTLVVVLARAGSLNPTLRAGYVRDMLNEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A537E3I8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVAFIGLGLNDEKGLTIEGLEEARQANSVFAEFYTNTMPGLDRKKLELLLGKKVVVLNR
VQLEDEEGKPIVEAAERGKVALLVPGDPMTATTHISIRLGLARRGIPSRIIHGPSVTSAV
CGATGLQSYKFGKSVTLPKEPGVPGSLLDTTRDNKNRGLHTLILLDIRPEMAEELTVREA
AAKLVAADPTLANWMGVGVARIGSGDQFVLSAKLQEFQSQDFGRIPHCLVIPGRLHFMEI
EALKAFCGAKDADLEALR
>A0A842XFS7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLFDEKDISLRGVEEIREANAVFAEFYTSVMPGLSVQKLEEIAGKEIKIVS
RRTLEEEDGKPILQEANKGKAAFLVPGDPLIATTHVDLRIRAEKQGIKTRVVHGASIVSA
VVGLSGLQNYKYGRSVTIPFPEKGFVSETPYEVILENRVMGLHTLCYLDIRAEEQRYMTI
REGLRSLLDTEKRKKAHVITLSTLVLGVARAGSDNPTVKAGYVGDVMNHDFGDPPHTLVF
PAKLHFMEAEALITLAGAPEQIRERFK
>A0A7J3T0L4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRRKQLGQIVFVGLGLHDDQGISLNGLEEVKAADRVFAEFYTSLLPGFSVERFETLAGKK
LTLLSRRDLEDLNGQAVLEAAEKERVALLVPGDPLIATTHIALRVEAEKRGVKTRIVHGA
SVLSAAIGLSGLQNYKFGKSVTVPFSDEASQATSYSVIAQNQKLGLHTLCLLDVKAEEKR
YLSIGEALGALLKIEAKEGKKSVTLYTLAVGIARAGSRNPAVKAEHVERLLSYDFGGPPQ
CLIFPGKLHFMEAEALIVLAGAPEDTRRLAE
>A0A7C0Z5M3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLCSERDITLCGVEEARTADNVFAEFYTSLMPNLALSELERLVGKKITVLS
RKDLEEDSGERILAAARRGRAVFMVPGDPLIATTHVELRVRAVKEGIKTRIVHNASIISA
VAGACGLQNYKFGRSVSIPFPNGGIFYEAPYDTIKTNKQLGFHTLCFLDIHAEEKRYMTI
REAVEILLALERKRREKIVTADTVAVGIARAGCVDTVAKADFINALAQFDFGNPPHCLVF
PGKLHFVEAEALITLCSAPEKVKELVQK
>A0A523W5V9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGISLRGLEEVKTADSVFIELYTNLMPDFSVENLEKISGKKLHVVSRRELEEDNGKALMA
AAEGGKVVLLVPGDPLVATTHVALRIHAEKLGINTRIIHGASIISAVIGLSGLHNYKFGK
SVTIPFSQTSETPYEVIAQNRKFGLHTLCLLDVDVEKNRSMKIREGLESLLKTEEKRKEK
IITMNTLAVGVARAGTNDPTIKAGFLKDLLDYDFGEPPHSIIFPSKLHFMEAEALIVLTG
GPEQLREMIE
>A0A7J2T7S5|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEIVFVGLGLHDETDISLKGLEEVKTADAVFIECYTSILPGFSLRRFEKLSGRTLRIVS
RKELEEENGEAILKAAEKGKAVLLVPGDPFVATTHMALRLEANRRGIKTRIIHGASIISA
VVGLCGLQNYKFGRSTTIPFPENYSETPYEIIAKNRKLGLHTLCFLDIDVETERYLTIRD
ALKMLLETEEKRKMDAVTKESLAVGIARAGSPDPTVKSDYVGELIFYDFGKPPHILVITG
KLHFMEAEALIAFAKAPTSVRRMIE
>A0A256YRP2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon ex4484_6|TrEMBL
MKKLSLIGMGIVNERSIPLLGLDRLKEANLIFAELFTSILEEGSLERLSQLAGKEIRLLD
REDVEETEMVLGAFENADRICFLTAGDPLSATTHQEMRLDAEKRGVEVEIINAASIFTAA
PGISGLQQYKFGRTTTLAFPEEGFFPTSPLDVIESNLERGLHSLVLLDIQAHRDRYMSAP
EGAALLLRMVEKKGGSPIGPETMMVAVARAGHHDRKLVYSSLGKLSNMSLGPPPHCLIIP
GKLHFLEEEVLDSFRVE
>A0A534L4Z4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFVGLGLHDEKGITLRGLDEARSADVVLAELYTSGLAGAALGSVERLIGKKIRRLS
RTEVEDGRTILDAAAKQKVAFLVVGDPMAATTHVDLRLRAASANIPTRIVHGVSILTAAA
GAIGLQVYKFGRTTTVPFPAAGFGPTSPLEGILENRRAGLHSLVLLDLREDGSFLTPQDA
IALLLRMAVKMGTSDFGPGTMACVLSRVGSREVRATGGPIGRLSDRDLGPPLHCIVIPGR
LHFLEKEALIAFAGAPHDL
>A0A6B0DTR4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLRLIGIGLNPKKHMTLEALEKINDSDEIYLELYTSRIVDMTLDELENLINRKITLLDRK
TIESEFLVERSRKMNVSLLVPGDPIIATTHIGLVISSIQNNVEYEIINGISVQCVVPSIL
GLQNYKFGRSVSIPFPEYDYYPESVYNFVLENRKLGLHTLVFLDLRESLEMSALMGIDIL
LKMESMYRKDAIDKNTIIAVISKAGSEKQRAIADKIERIKERDLGPTPHIMVIIGSLHYM
ELEALKKLASFPENENINLL
>A0A7J3ANV8|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MYFIGLGLYDDSSITLQALEACKESDVLLMESYTSALAEGSIERLVNMIGKPIELLTREQ
VEKGDFLKALKGKSVAFLVPGDPMMATTHIDLRIRAHDLGFETNVIHGTSVLVAVPGILG
LQHYKFGRTITIPYAQEGFRPRSPVEHLTQNISSGLHTLALLDLRASEGRYMTANEGLGW
LIETAKELGIEDINESRLACVVARAGAPDCKAKADRIGRLIKLDFGPPLHTLVIPGRLHF
MEIEALKRFAGAPDDIWSG
>A0A327HAT5|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MDTSGLFLIGLGPGDLGLMSQRAINLLQDMDERYLEGYTATLPIDQESELENLVGPWKRV
MRPKIENPREIIEEAKTRKVAIMVVGDPMQATTHVDLLLRAKENGVRVTIVPGISATTLA
ISSSGMQSYRFGRQVTLPYAYGDYLPTSPLRYILDNXSRNLHTLVLLDLXPTGLGIXDPI
HMSPPVAGQILMQMAERWNEENEEVDVSTWNVVVLSDLGTAQSHVCSTIIEEMEGMDKGR
IHCLILPAEMDNHELMVFDSMRYHA
>A0A8J7W4D4|diphthine synthase|EC 2.1.1.98|Methanocalculus chunghsingensis|TrEMBL
MLTFIGLGLYDEKDISCKGLSAIRTADAVFLEYYTSRLMGTDIPSMEALYQKKIHLLSRE
DVEQHPDPILDAAAVGSVVFLTGGDTMVSTTHADLRIRAAERGIPTQIIHGASISSAVCG
LSGLQNYRFGKSCSLPFPHGRWMPTTPVEVIATNLAQNLHTIVYLDIQNTRYMQIPEAIV
IIEEIAEKKGIEIPLYVGIARAGSDNPVVLAGGADTLASSDFGPPLHILVVPAELHMMER
EFLERFAGLAPSP
>A0A842LJW9|diphthine synthase|EC 2.1.1.98|Archaeoglobi archaeon|TrEMBL
MLIFVGMGIYDERDISVKGLEAVKKADAVYAELYTHKGSFSIERLSKFFGREIKELKRED
LEERAERIIEEAREKDVVLLSGGDAMVSTTHADLMIRAKRMGVQTKIIHASSIISAIPGI
TGLQNYRFGKSATVVYPYFIGERRILPETPYDVILQNLRNDAHTLLFLDIRERCMTIPEA
VEILLEIDDRRERILRGRIAIGVARAGSDDCTVAVDRIERLIQKDFGDPPHSLVIPASLH
VIEEEYIKEVIGGFKE
>A0A523ABY5|diphthine synthase|EC 2.1.1.98|Archaeoglobi archaeon|TrEMBL
MLFLIGLGLWDSKDITLRGLEIVKNSDAVYAELYTSKLGVGVEELEKFFGRKIEVLKRED
LEDKSYRILERAKKEDIAILVAGDPVIATTHISLLIEAKKLGIPARVISNASIINAVCAL
TGLQNYRFGKSATVSWQKSRHFIDVIKANLSIDAHTLLFLDLNPPMKICDAVEKILELEE
SLGKHFAVGIARAGSDNPAVKCDRLKRLVEFDFGEPLHTIVILSRRIHFMEYEALKLLAS
APEELSEWVV
>A0A2V3JB03|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MLTFVGLGLYDPEDITLKGLEAIREADVVYAEFYTSPAGARTIEKLEEAYGRRISLLARE
ELEEGAERGILELAKSKKVVLLSGGDAMIATTHVDLRLRAIERGIETRIVHAASIASAAA
GLCGLQNYKFGKSATVSPPYKGVVSHVPYETIEDNSERGLHTLLYLDIGMRIADALELLE
LVERERGGEVLKRSLLVGIARAGSDDAVVKADYITSLKGYEFGDPPHVLIVTGDLHFVER
EALIKIAHAPGSI
>A0A2R6T6G7|diphthine synthase|EC 2.1.1.98|archaeon SCG-AAA382B04|TrEMBL
MSLTFVGLGLFDEKDISLKGLERAKEADVIFAEFYTSKLFGAKKEDFEELFERELRVLSR
EEVEQQQKPLELAHENDVVFLVPGDPMISTTHTDLRIKAMENAIETQIIHASSIFTAAPG
LSGLQNYKFGRSATVTFLSRGEVAESPYNAIKQNKENGLHTLLFLDINEEKNRYMAPNRA
LELLLKIEEGRQEEVIGRENLAVVVSRAGSDDVEVKVGEVNDLLEFEFGEPLHSLIIPGE
LHFREEEALRAIRKG
>A0A1Q7IC24|diphthine synthase|EC 2.1.1.98|archaeon 13_1_40CM_4_53_4|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDSVAFLVPGDPMIATTHISLRLSLSKTGIGSRIIHGPSIISA
VCGATGLQSYKFSKTVTIPYDPPLPASVLETISDNHGRGLHTLLLLDVKADQNKQLTIAE
ALTKITSANPSLESRLAVGVARIGARDERVKASRIGLLINEDFGGPPQSIVVVGKLHFME
ADALRIICGAQDSDLRENY
>A0A498H611|diphthine synthase|EC 2.1.1.98|Methanohalophilus sp. WG1-DM|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNAGKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEINIAFLTGGDTMVSTTHVDIRLRAMEMGIETCLIHGASIVSAICGL
TGLQNYRFGKAATIPYPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMDKGYMTV
NQGIELLLQVDEKRGENLIKGSIAVGIANAGSEKPIVRADFAENLESCDFGSPLHIVVIP
ADLHFVEAESLIKLADAPESILEEGDIN
>A0A4D6HAK7|diphthine synthase|EC 2.1.1.98|Halapricum salinum|TrEMBL
MLTFVGLGLYDESSITLQGREALQEADRVFAERYTSRLVGASFEDVEAAHDVEIELRSRE
GVEQHPEPILDAASEGDAVFCTAGDTMISTTHVDLRLRAHERGIDTRIVHGTTAAAAASS
LTGLQNYRFGKATTLPFETSHGGEGVPGSVIETIEANRDRGLHTLVFLDIKVDDDREDYM
TGSEAADLLASDWDDEALGVVVARAGSPDPVVAADTLDALAEMDFGEPLHMLVIPGELHY
IERDALVELAGAPESVADSRLV
>A0A3N6LKJ8|diphthine synthase|EC 2.1.1.98|Natrarchaeobius halalkaliphilus|TrEMBL
MLTFIGLGLYDERSITIEGRDALRNADRVYAEFYTSELIGTTVAELESYHGVEITVRDRA
GVEQRPDDILRAAGSENVVFLTAGDTMISTTHVDLRLRAHDRGIETRIIHGITAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIEDNRRDGLHTVVYLDIKVEREEYMTA
DVGADLLAEAYPDLVGVVVARAGSPDPLVDGGRMSDLATREFGDPLHLLVVPGECHLLEA
DALVELGGVDREHLDVV
>A0A522E1T6|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLTLIGLGLHDEKDITLRGIDAAKNADKVYIELYTGKWFGSLDRLEEIVGKDIVELKRSD
LEENSNRILDEAAKKDIAIFMQGDPLVITTHNSLIADARKMKIDTKVIHNASIFSSIAET
GLHVQKFGPSVAISFPEKTKGKLPESVYKTILDNKKRGLHTLCLLDLVDGKVMEPKDALK
ILQALDKEKMISDVIVASRLGGKSKIVSGKIGDIMDVKFEEPSVVVIVGNLHFTEKEFLN
I
>A0A7C3Z3M2|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MGLILVGTGLWDERDISLRGLDALKQSDIIYAERYTSEKKEGTLERLEALCGKGITVLSR
EEVEEGKRIMDEAERRKVSLVVAGDPMISTTHVSLKLEAHRRGIPFKVIHSSSILSAAIS
ESGLHTYKFGRPVTLPFWSEKYKPTTTYDVIRENSERGLHTLLFLDLKDGVGMRAHEAFS
LLRKMEKEKKCGVISDKTMLVTLSRVGSEEQKVAYGPLELLEKAELGEAPFIMIVLGKLH
FTEEEA
>A0A831NX91|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
PLMKQNNKNSTSRAEKPRNKRLPTTDYRLPTTKKNGFFLVGTGMTQNSIPADALQALKQA
DKIYLENYTVNFPYPKEELEKEINKHLQPATCNLQPLPRESVEDESILEEAKTQNIALLV
YGDSLSATTHMQLILECKKQNIKHKIYHNASILTATAETGLSLYKFGKTTSMPNWAEHTN
KPTSFAAYIKQNQSIDAHTLILTDIGLEISPAIRQLIESSEKENLELPEKIIAISHAGAS
EQKIFHDTPENLKNKDISMPFCLIVPSELHFLEEKALGRLKE
>A0A662UHH8|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGKLYLIGLGFSPDLMTLRALNIVRSVRRVFLDKYTGILIDNGEKIREIVGRDVVPLSRR
DLEERSFEVIIRELEKGDVAILVPGDPLVATTHIALLVEASKYGFDFEVIPGISIVPTAL
TMSGLMVYKIGKVVTMTYPRNGILYEYPYDVIKDNDARNLHTILLLELDAEKGIAMKVGE
AIDILFEIESKRGEGVIRPERLGIGIASLGSSKARICPMTLEELKKCDIGDVPHTLILTS
PKLHFMEEEALKVIRDAFCREVCK
>A0A662JHW3|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGLHDPLDLSVKGVETAKRCDKVYVEHYTSLMPGFTIKDLEKLLKRKVEVLTREDLEGEK
GKKLVEEAKVKDVALLTPGDPFIATTHVTLRLAAKKAGVEARVIHSSSIATAAPGLVGLS
FYKFGKTATVVYPEPGYYPETPYDVLKENLRRGLHTLLVLDLKVERGLYMSIPEALQILL
SIEERRLEKVLDLNTLVVGIARAGSLSPTVKAGSIERLMKISFGPPPHSLIFPGRLHFIE
EEALIELCEAPRDVIEKHKAKFTAP
>A0A662GTY2|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLIFVGLGLHDLQDLTFHGFSVLKKAKKIYMETYTNIMPDFSRERLETLIGEEIVEVSRE
FLESDKISQIIEEASKEDVVLLVPGDPFIATTHITVRIEAEKRGVKTMVVHAPSIISSAI
SECGLQIYKFGKIATIVYPEPELGFFPFSVYEVLKENLSRRLHTFFLLDLKVETGKLMTI
SDAIDVLFMMEEKLNEGVVTSDTLGVGLARVGSPNTILKAGSLAELKSYNFGPPPHSLII
PSILHPIEAEALIFLCNANKRLIEKWTRKIG
>A0A133V2B2|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA259M10|TrEMBL
MLLFVGLGMNSKGISIQGLEEARSADVVYAEFYTSIIPGFEIEKMEESISKPIRVLDREA
VEVSPDEILKKSETKKVVFLVPGDPMVATTHVDLRLRAGKRGIETRIIHGASIETAGPGL
AGLQSYKFGKTATLPLPEKRSITPYDVLEDNKKQGLHTLFLLDIEKEEERYLTADRAIEY
LLDLEEELERKVYTGDTLSVVVARAGSEDPLVKADRCGNLIGRGFGRPPHILIVPGKLHF
LEAEALEYFADAPKEVVEEYVKE
>A0A498E771|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-109R|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7D5T6L4|diphthine synthase|EC 2.1.1.98|Halosimplex rubrum|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRAADRVVAEFYTSKLAGATLADLESYHDTEIEVRDRA
GVEQSPDDVLDDAADAEVVFCTAGDTMISTTHTDLRLRAHDRGIETRVVHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHAGDTLPESVVDTVDANRERGLHTLVFLDIDAEHDDYMRA
DRAAARLADAYEDALGVVVARAGSPDPTVRADRLSALAEASFGEPLHLLVIPGDLHLMER
DALAALGDAPTDLLEELVV
>A0A7L4PMU3|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosa archaeon|TrEMBL
MLYLIGLGLTEKDLSLKAFELLNKVNNIYVDTYTNYFDFDLIWLEKSLEKKINSLSREDI
EKNPEFLDIAKNDDVALLVSGDPLVATTHTDILLRAIKKGVKTKVFHASSIYSAIAETGL
HIYRFGKTASIPYPEENFFPRSFYDVSMENKQRNLHTMLLLDVKKEKNQFMNPKEAMDIL
NKIDENKNIKDIIVISRISHESQRIIYGDMGELLKFDKEFYGPPPHTLVIPAELHFAEEE
YLLNIAEIHKNSKSK
>A0A7J3WVQ8|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MVLYLVGLGLGSLDYMSLKAAEEIKNCYTVYLDTYTGFISKDLMNWLTKEFYGRLRLATR
RDLEDNLGRILEEARETGIAILVPGDPLIATTHISLLVEAAKRKIPYKIIHGISIYSAAV
SITGLQAYKFGRTTTLARLGDPRETYRIIKENLERGLHTLVLLDTADGGLTIPEALRRLL
EAEDSLRQGIVREDTLAIGLARIGLQEELVRVATVRELIIESYPPPPHALIFPGELHFME
VEALTRLYNIDEEIVKRHKPLGYGKERVWRYIMKTRGVANSLKVREPSREIQKILEIASS
YIEDAERFWSSGELFNALASIAYAEGLLDSLRMIGKVDFQWL
>A0A846ND27|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLTLIGLGLHGFEGISLRGLETARRADKIFLEVYTSPTIIDMNKLQNKLGKSVSILRRED
IEEKDTLLSEAEGKEIALICPGDPLIATTHINLVIEARKKGVETRVLHAASIYTAAIGES
GLHIYKFGRMATLPIPSDFLPFSVYECIEENKKRGLHTILLLECDVEREERLSVGEALKT
LLRMEAERKGNIINKKQTIIILSGLESAEGFKDAGIMEDIMYKEFPALPTAMIIPGRLHF
TERAAFESFFHLKNPCT
>A0A8J8EZU8|diphthine synthase|EC 2.1.1.98|Thermococcus sp. Bubb.Bath|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCEKVFAEFYTSLLAGTTIEKVEELIGKPIKRLSR
EDVELNFERIVLSEARDKEVAFLTAGDPMVATTHADLRIRAKKAGIESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTLLFLDIKADQGRYMTANE
AMEILLQVEEMKGQEVFTPETLVVVLARAGSLSPTLRAGHIRDMIKEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPKEILDEV
>A0A401HRI5|diphthine synthase|EC 2.1.1.98|Methanofervidicoccus abyssi|TrEMBL
MLILAGLGLYDEKDMTLKTLEYAKRADKIYAEFYTAALTGTTLNKIEEVIGKKITLLSRE
DVECRSDKLIEESRNKTVMFLTAGDPMVATTHVDLVIEAKKRGIDVRVINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYYVIRDNLRMGLHTLCLLDLDSDKNRFMSANEGL
KILLEIENRRRENILNENTKVVVLARAGSFKPKIVYGKIKDLIDYDFGPPLHSIIIPGKL
HFMEEEALKYLCENIS
>A0A843LRB1|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLTFIGLGLYDEKDISVRGLEAARAADRIYAEFYTSRLMGAGYERLEAFYGKKIHLLSRQ
DVEVDPFWLKDALTMDVAFLVGGDAMVSTTHLDLRLRAMEMGIKTRVIHSSSIATAVSGL
CGLQNYRFGRSATIPFPYVSRGKRIIPETPYLVLKENQSRNLHTMLFLDIQAAPVERYMT
VPEAAALLMEMQDAAGERCLDGLIGIGIARAGSEDAAVHADLLPRLKSYDFGGPLHILIV
PARLHFMEAQALRILASASGDALQ
>A0A0P7HVI1|diphthine synthase|EC 2.1.1.98|Halolamina pelagica|TrEMBL
MLTFIGLGLYDERSITVEGREALAAADRAFAEFYTSRLVGTTVAELEAFHDIEIDVRDRA
GVERDPGPILDAAEDDHVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVSAQSAAAG
LTGLQNYRFGKATTLPFPGAHGGGDVPDSVIETIEANRERDLHTLVYLDIKVDDPTADAA
GLGEDERYMTGDYAADLLGENWADELGVVVARAGSPEPVVAADRLSELATRAFGGPLHLL
VVPAEPHHLEAEALEALAGAPAELLADS
>A0A7J4RBF7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MSLTLIGLGLCDYNDISLRGLEALKQADVVYFENFTNILACSIKEMEKAYGRMITPVKRE
FLEPGEGLIAEAQSRRVALLVIGDPLTATTHISLFLRAKEKGVAVEVIHNASVMSAVAIT
GLQPYKFGMTSSLPFPGSSFKPETAYEVIKRNKASGMHTLLLLDLKPDEGRFMGIGEAID
ILLSIEEKRLDGVFATNTPCIGCARLGWPDCRIICGKASELRKADFGKPPHCLVVPGSLH
FVEEEAIGGYRLNHS
>A0A7J3LMS3|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MSLYLIGIGLWDPTDITIKGLEAVKRCEHVYLESYTSKLGCTIEDLEALYGKKIIIADRD
TVENADRILDDARSSDTALLIIGDIFSATTHIDIALRAWEIGIKVHCIHNTSILIAIGEI
GIDLYKFGRTVSIPFHNKNVSSPAEMIRKNLSMNLHSLVLLDLSPKDEKYMTSSDAAAYL
LANGFDREQRVIACAGIGSSGQEICYSSLRKISERYLSKIPQCLIIPANLHFMEEKALSR
FADMD
>A0A7C3J3L5|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylicus mesodigestus|TrEMBL
MSIHALEKARAADEVFLEGYTSLLPGFSLRSLEDMIGKRVIALGRSAVEDGSIILSAASS
KDVAFLVAGDPFVATTHVDLRIRAMKRGIRVEVLNAPSIISVAPGALGLQNYKFGKSATI
TFPDNPSDAPYDALRLNKAAGLHTLFFLDLRAEEGRFMSAGEGLRLLLDAERRLMGGIFG
EGALVAVLARAGGPQQLTVAGTAGELAARDYGPPPHCVVVPGKLHFLEAEALSLFAGADE
ELLRRNM
>A0A843IWN3|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MASELIFAGLGLSGADGMSVKALNALKECDLIYAEFYTSHLIGTGIEEVEKAIGKKITVL
HRMQVEEGTDIIENAKTQRVGFVTAGDTMSATTHVDLMIQAKEEGIPVRLFNGVSIFSAC
PTALGLQPYKFGGAVTLPFIENGYQPQSPYDKILENYERGLHTMVLLDIHADELRYMTGK
EAIEWLLLAEEKWGKGLIRDDTLICVASRIGSEEQKLTAGYPKQLLEMDLGEPLFTLVIP
GKLHYMEAYALVYFAGAPESIIEDE
>A0A843JWI6|diphthine synthase|EC 2.1.1.98|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MTSELVFVGLGLSGTDGMTVKALNALRECDVIFAEFYTSTLIGASVADLEKVVGKKIQLV
YRSQVEEEGSIIEKARTQRVGFVTAGDTMLATTHVDLRIQAAEEGIPVRIFHGVSIFGAC
PTSLGLQPYKFGRTVTLPFMERDYQPKSPYDHIMENKSRGLHTMILLDIRADELRYMTAH
E
>A0A2K5ASG9|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosocaldus cavascurensis|TrEMBL
MLILVGMGIHGYKGLSIEAMEAIKDADKVYVEAYTSPVKSRDIDALRALRDDVVEVHRWF
VEDGRRILDEARAGDVVLLAYGDPLIATTHIELLVRARSSGIACKVIHSSSIVTAALGEC
GLHVYKLGRVATVVSNPIANTSTYYAIYSNLMQMNHTLLLLEYDQEHGYFLAVDSALRLL
LDCEARERMNAIDEDTFAIVASRVGMEDMGIVGGRIGSLLKYSDEHGFGEPPHTLIVTGS
LHFTEVEALRASVMLLDEPIDNSKRVRARAEMMLPNYIARAYNALSRAREYIMHAKGSAG
DKAKDKDKDDTIERIKDMIDNAEYYLSDAERFAREHRYENAILALGYAEGLIDALRYLRD
IDPWESKKSTIT
>D4GUZ5|diphthine synthase|EC 2.1.1.98|Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)|TrEMBL
MLTFIGLGLYDERSVPVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A843IZS5|diphthine synthase|EC 2.1.1.98|Methanomicrobium sp|TrEMBL
MLTFIGLGLYDERDISVKGLEIIKSADKVYLEGYTSRLMGADVRKLEEFYGKPVTLLNRD
DVERFPGKILDAAAEGEAVFLTGGDPMVSTTHADIRIRAEERGIATRIIHGASIQSAVCG
LSGLQNYRFGKSCS
>A0A371LB26|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-19N|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEYVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVESDALSALGGAPEELFDDEN
>A0A1I6SCL9|diphthine synthase|EC 2.1.1.98|Halostagnicola kamekurae|TrEMBL
MLSFIGLGLYDERSITVEGRAALRDADRVFAEFYTSALLGATVEDLEDYHDVSIDVRDRA
GVEQRPEEILEAAETESVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGTATTLPFPYAHGADGLPASVTNTIDANREAGSHTVVYLDIKVDNEAALER
VDTDEAVAEYMTADIGAELLAEEYPDLVGVAVARAGSPDPLVEAGTMTELATREFGDPLH
LLVIPGECHLLEADALVELAGADRDALDIV
>A0A7J4TV10|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MKAGLRLIGIGPGDLGLMTVNAIEAAKESDHRFLEGYTATLPPEQEGVLEDLIGSWTRLM
RPDVEKPDELLRLARSSTVALLVVGDPMQATTHVDLLLRAKDAGLDTEMIPGISATTMAI
TMSGLQSYRFGRQVTLPFPYGDYLPVSPLRYILDNRSRNLHTLVLLDLDPTGLGVESPVH
MSPAEAGGILLKMVEKYEIEGGSKEDLVEGILDWPVIVLSDLGMVDCRVCSTNLRNVSDV
KGGRIHCLILPSSMDDLEQSSFDGMYIGD
>A0A7J4NR07|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MDSSGLFLIGLGPGDLALMTRRAIDMLQDMDERYLEGYTATLPLTQENELENLVGPWKRV
MRPQIENPREIIEMAKSLKVAIMVVGDPMQATTHVDLILRARENGVKVTIVPGISATTLA
ISSSGLQSYRFGRQVTLPYAYGDYLPTSPLRYILDNRLRNLHTLVLLDLDPTGLGIESPI
HMSPSVARQILMQMAERWSGENEEVNVSAWNVVVLSDLGTAQGHVCSTIIEEMNGMESGR
IHCLILPAEMDNHEQMVFDSMRYHA
>A0A7J4NEM2|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MTDGALPAGLWLIGLGPGDLGLMTADAIEHARACEYRFLEGYTATLPDDQEQRLESVVGP
WERAMRPMVEEPEKILAMAKESSVALLVVGDPMQATTHIDLESHCAEQGIDYSIIPGISA
TSLAVSVSGMQSYRFGRQVTLPFAYGDYLPTSPLELIDANYTNNLHTLVLLDLDPTGMGV
DTPQPMNPSQAVDLLQKMFEKLVDAEGSVRESMTTPLAKWNGILLSDLGTHEQRVVSGDL
GDIATIEGGRIHCLILPAEFTGMEREAYERRRG
>A0A3R7UUV4|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED192|TrEMBL
MKAGLRLIGIGPGDLGLMTVDAVEAAAGSDHRFLEGYTATLPIEQEELLESRIGPWNRLM
RPDIEMPEELLRLARSSVVALLVVGDPMQATTHVDLLLRARDAGLDTEIIPGISATTLAI
TLSGLQSYRFGRQVTLPFPYGDYLPVSPLRYILDNKSRNLHTLVLLDLDPTGLGVTSPVH
MSPAEAGGVLLKMVEKYSVEDDSEMGAVKGVSDWPVIVLSDLGTRESRVCSTNIRGISNV
KGGRIHCLILPSSMDDLEQSGFDGMFVGD
>A0A497S2D2|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon|TrEMBL
MFYLIGIGLDEKDLSLRALKILMNVDTIYAEFYTSPFSGKIENIERLLKREVILLNREDI
EENFENILINSDKKDVALLVPGDPMVATTHSSLVMEARKLGIRTRIIHSSSIYSAIAETG
LQVYKFGRTTSLPFPRRNYFPTSPYDVIKENTERGLHTLILLDIDMLINNAIDILLRIEK
RRLEGIFNEDRMCVGVARLGSEDSIIKYGRAESIREYDFGKPPHSLVVPGELHFMEEEYL
KFFRI
>A0A662I8H9|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLVIVGLGLYDLRDLSLGAFDTLRRASKVFVELYTSIVPGFKLEELERLLGRHVEVVHRH
QLEGRWLDELMEAARREDVALIVPGDPFIATTHITIKLEAIKRGVKVAVYPAPSIINAVI
ASTGLQVYKFGRPVTIVRQSPLYSPVTPYYVLYENLRRGLHTLFFLDLDVEEGYAMTAIE
GIEVLRCIEEREGLGLIDEYTPFIAVARASSPDEVVKVIRLGEKADLGPAPHTLIVPGLL
NPVELEALCLLAGASTDLLSRWHKRVRGLAASEA
>A0A7J3LYQ2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLKLIGLGLNVYGITLEGLSEARSCDKIYVELYTSIIPNLNLDTLRQIIGRDITLLKRRD
IEEGSDYIIEEAGRYDVALLTPGDPLVATTHISLVIEARRRSIPVKIVHSSSIISAISGA
TGLQIYNFGRVITLTRAAGGSLPLSVYDVVEDNLGRGLHTLILLDIDVEAGYWMSISEAV
GILEAMESIVGKNIFSNDRLTVGVARIGSTDAVVKADKLSKIKYYDFGGPPHSLVIPGRL
HFMEVKALICLADAPQDLLKIA
>A0A7C2VIQ6|diphthine synthase|EC 2.1.1.98|Fervidicoccus fontis|TrEMBL
MTNNEITNGKCLGELSFVGLGLSLSHISIEGIKKLKSSDFIFLEGYTSFYFPEINAAMKV
IGIKSDRFKIISRRDIEEKSGQEIIDLLLKGKNISMAVIGDPFIATTHLSLKNYAKEKGC
KVNYIPGINIFSYAMSATGLFNYKFGPSATIVYKREGILSVYPYLVLSGNLSRGLHTFFF
LDIDAERGPLNASEAIKLLIEMEKEERLGIITPETKIVVLERLGWPDEKIYYGKISLLYN
MRFNPPNSIIIPGKLHFMEEQSLEAFSIERNER
>A0A7C1PD72|diphthine synthase|EC 2.1.1.98|Thermofilum pendens|TrEMBL
MLVVAGLGLYGTRDVPLGVLELLRKADIVYFESYTSLAPSLDKECIERLCGREVKEVRRE
DLEERSAREILAQAAEKLVLLLTVGNPLLATTHTAIILEAKKGGVPFLVIPSASVIDGVV
CATGLHIYRFGRVTTLAFPDEEKGFYPFSTYLAIKSNLCRGLHTLVLLDLRAEENRYMDP
GYAAQLLLKLESMLSEGVLDEDTLVIVVARATAPDQEVRVCTLSEAARRSFGQPPFSLVV
PGLLHATEIEYLHYVHGAPLEVMLKWNECVKRRFSSTLEV
>I7CSF1|diphthine synthase|EC 2.1.1.98|Natrinema sp. (strain J7-2)|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRVYAEFYTSKLIGTTIEDLESYHDIEIEARDRA
GVEQHPDDMLEAAESENVAFLTAGDTMISTTHVDLRLRAHDRGIETRVINGVTAQTATSA
LTGLQNYRFGPATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKAERGEFMTA
DVGAELLATDYPDLVGVVVARAGSPEPLVEAGTMSELATREFGDPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A520JUZ0|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFIGLGLYDEKDVSLEGLEAIRSADKVYLECYTSLLTGTNIKQLEKLYCKKVHLLERE
DVETDNWWLKDAIDQSIVFLTGGDAMVSTTHIDLRLRAKKLGIGTRIIHGASIISAVCGL
SGLQNYRFGKSATIPHPYTRKEKIIRSHTPYDTIEINQKNNLHTLIFLDIDKNIGCMSIK
EGIELLLQVEEEMGGEAISNCIGVGIARAGSFAPVVKADYLENLKHTDFGEPLHILCITA
NLHFIEAEALIAFADAPGSILNRHNDSLRQD
>A0A533XIV2|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MMGRLTFVGLGLGARGISLEGVVAVKEADSCYLEYYTTPHEPTLLKELENETGRVMTVVD
REFVEDGREILKEARGSRVVLAVPGDPMIATTHNELRVRAIGQKTETAVIHAATIPSSAA
SASGLHYYKFGRMMTITRETLDSMQQAYHTLQTNLLQGLHTLLLLEFDVEGGEGAAPPAV
IGGLLRAEKNFGREVLTEETFALVLSRLGRQDSELRAGCLKDLRNSEYGEKPHCIVIPGG
LHFTEVEAVAAIFGLGEGEVRDNSRNMKGTAEVLIPRYAAKTRRALNSARERLGRDYDTL
LENVELYTKDAEGFLARGEHELAMLSMGYAEGLLDSAGFTGRAKIDW
>A0A7M3Z368|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTHLTRRGEQPCSLDDNGEVSSMNSDNGLWLIGVGPGNIGLMSLDAIEAVKRCDYRFLEG
YTALLPTDQEEELENLVGEYKKIMRPDVENPEDLLKLAKEGAVALMVVGDPLQATTHIDL
QLRAAEANIGCHVIHGISITTIVTGVVGLQSYRFGRQVTLAYPYGDYLATSPFELILENL
ERNLHTLVLLDLDPSGMGEGEQQPMSPRGAVEILQLSAKKLKHDIEDWNIVLCSDMGTTS
QRINYGSLDHISAIESGDIHCMVIPGRLDDLEQEALARWKA
>A0A6V8DCK5|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MMGSGAARFTMTDDGVASGLWLIGIGPGDLDHITERAKRVARECSKRYLEGYTAILPPIE
EKRLESVVGPWERLMRDGVESPENMLDEARVDSVALLVVGDPMQATTHIDLEERCAEEGI
GFHVIPGLTATALAVSLSGLQSYRFGRQVTIPFSDGEYLPTSPFEMICKNKEAGMHTLAL
LDLDPTGMGLEQPRPMTPREAVDHLIRMNERSEEYNQPVEDWRGLLLSDLGTEEERVVSG
KMRNLSQIEGGHIHALIIAAEFSGMEAEAFERRRLTEETTG
>A0A7J9RG12|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MVFAMPRGASGLSMAAGLLLIGMGPGGISGMTRAAIQAAKSADHRRYEAYTALWSKDSLS
ELEEEIGPIQRVMRPEVEDPVEILELAKSQTVALLIVGDPLQATTHVDLQLQAKESGIDC
TVIHGVSITGLVTGAIGLSNYRFGRQTTLTYPYGGWIATSPLEVIATNRFQGLHTLALLD
LDPTGEGIGGQKPMQPSDASQAMYTMAEKLSQSVEEMSEDSVLDSLKIQACREICSNIDS
LMVVLCTDMGTENQTISYLSLEQLSLANTGGLHCLVIPAKPTDVEEIALNRWSKK
>A0A7M4A7A9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MISKTDNDFGSSASVDGESGISLDKPSSDEKILCPSASQLFSVIKDRAPSTFLFGTNKCR
IMFIMCRRLGRFTMTETSLPAGLWLVGLGPGNLDYMSKYANDITKSCSKRYLEGYTAILP
PKQEEKLESLIGKWERMMRPDIENPEKLLKMAKEIPVALLIVGDPMQATTHIDLEARCEE
MGINFNVVPGITATALAVSLSGLQSYRFGRQVTIPFSYGEYLPHSPLEMICKNYENNLHT
LVLLDLDPTGMGVNNPKPMKPDEAISLLARMAGKILEETSTFEILKKPVDEWDGILLTDI
SMVEQKVTAGNLSQLSKLKEGWIHCMIIPSNMNDNELEAFERRKNC
>M0BE65|diphthine synthase|EC 2.1.1.98|Halovivax asiaticus JCM 14624|TrEMBL
MLTFVGLGLYDERSITVEGRAAIRDADRVFAEWYTSELIGTTVEALADHHGVEIEVRDRA
GVEQDPDPILDAAASGDAVFCTAGDTMISTTHVDLRLRAEERGIETRIVHGVTAQTAASG
LTGLQNYRFGPSTTLPFPWAHGADGLPASVTNTIDENRDRGLHTLVFLDIKAAEEEYMRA
DTAASLLTEAYPDLVGIVVARAGSPDPLVDGGPLSDLAERDFGDPLHLLVVPGECHLLEA
DALETLADVDRKSLDVA
>A0RTV4|diphthine synthase|EC 2.1.1.98|Cenarchaeum symbiosum (strain A)|TrEMBL
MLWFVGMGLAGAGSIPADAKNVIEQAEMVYLEGFTSIVTESDERALEEMAGGKIIPARRW
MVEDGKEILDNARTKKVVLVSYGDPYTATTHIELRTRAAELNIPTGSIHAASILASAVGE
CGLHHYKMGRTATVTRDPRAASTPYRIIYENLVSGSHTVLLLEYDQDGGFFLDPGDALGL
LIEYEKEQRRGVITDELFAVIASRIGMKGQSIVAGRISSLKGYDFGAPPHAVIIPGGLHF
TESEALSASAKCLDAPSDNSERMPSIPQQMVKKYVPMVRDAMKTIEALEDNPPEYGHVLE
NAGHYLRDAEEFMGKGEGELAVLSVGYADGLVDALRMARGIDRVQ
>A0A7J2L5W8|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLTLVGLGLWDEKDLSLRGVEEVLKADEVYIELYTSRWYGNIENLKRLLKKEIKVLERSD
IEEKYEKILEKAKEKCIALLVPGDPLIATTHSSLILEAKKRGIEVKVVHASSVYSAVAET
GLHIYKFGASATVPFPERTQEVLPISTYEVIRENKKRGLHTLLFLDLIAEENKFMNPNEA
MKILLKTEETMKENVFTENTHVVVFCRAGSENSSIFYGKVKDLVKIDFGEPPYVLIVPGK
LHFTEKEYLKLFKVEE
>A0A7C5U903|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLVLAGLGISDEKGITLEELEEARSSDLVFLELYTSIWHGSIENLERIVGKEIQILKRKD
LEEEVHK
>A0A497SS94|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGLWDEKDISIRGLETAKKCDFVFIEKYTSFWTGNLKNIGITAEEIKRTDLEDN
VDKILEKSKDKDIAILIPGDPLVATTHISILLEAKKKNIETKIIHSSSIFSAVLETGLQI
YKFGKIATIPFYQTEVPSKILEENLKNGAHTLFLLDITKEKLMSCAEGLKILLDLENKFK
KKLISKETEVVVFCRVGSSEQILKYDKIKNLIDLNCSPCVIIIPGKLHFLEKEFLTSLKN
>A0A846PHQ7|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLIGLGLNDETDLTLKAIEAVKKCECFIELYTSVWKGSLENLKEIIKKDIKILNRKDL
EENLELFIENAKENDVALFVPGDPLAATTHIDIVFEAKRRKIPVKIIHNASIFSAIGEVG
LQLYKYGKVATVPLSGKMKNVKDAVKRNKRLGLHTLLLLDIDLENNIFMKVLDAIKMLLK
KKVIKETDQIIAFSNAGGDSEIYYDSARGLKMKEIENPAVLIIPGRLHFREKDFLEVI
>A0A7C0UR83|diphthine synthase|EC 2.1.1.98|Thermococcus sp|TrEMBL
MGELIFIGLGLYDEKDISLKGLEDAKRCDYLFAEFYTSKLTGTDISKVEKILGKKIKVLE
RKEVEDGEQILKEAEKGRVGFLTAGDPMAATTHVELRIRAEERGIATRIVHGSSVFTAIP
ALLGLQHYKFGRTTSLVYPEDKFFPTSPYYVIKENKERGLHTLVLLDIDAEKERFMTIRE
GIDILLEMENRLKEGVISDDTIVCGVARAGSKKPIIKAGSILEVRDFDFGPPLHTLVVVG
KLHFMERKALETFADLARENRSV
>A0A2G9M0Q0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_45_5|TrEMBL
MALYLIGIGLYDEEDITLRGLSLAKDSDYIYLEGYTSLSSATIEGLEKKTGKKIEKKERE
FFEQGSKSIIALAKKKNVGILVIGDPLSATTHIDLLNEAREAGVKAEIVNNASIINAIGI
TGLQPYKFGKITSIPYPQGGYMPETPYNILKENLSINAHTLLLLDLSPKDGKFMTANEAI
EYMLSLEEKKKAGIFTKDTLVIGCARIGSRSPTIKAGKAGKLLSEDFGNPLHCIIIPAKM
HFVEEENIRKWMIK
>A0A6B9TKM5|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp. THM-2|TrEMBL
MLYIIGLGLYDENDISVKGLKALKACSRVYAEFYTAILQGASLSAIEELTGKDIDILRRE
EIEEERIPLLEAEKSDVALLVPGDPLVATTHTELILDARRRGIETRVIHASSIISAAPGL
AGLQAYKFGRIITVPFTSENYFPTSPYVNIRDNLERDSHSLVLLDIEAHKRRYMTANEGL
EYLLRASEKLGDDTINEKTLAVVIARAGSERPLVRADAISSLIKEDFGDPLHCLVVPGAL
HFIEAEYLVEVAGAPRSIVEGMII
>A0A075I418|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote KM3_91_D09|TrEMBL
MLTLVGLGLGGPESLTQAGIAAIREATAVFAEGYTSPLLPETLVWVEQKAGRVRLLSRAE
VEQPETLLAAARDGDAVLLVSGDPLSATTHVSLRIQCRETGIECCVVHNASVLTAVAGEL
GLQHYRFGPVATLVTPKGDYHPLSPVKRVLQNIEAGFHSLVLLDIRADDPAAEPRLMTAI
EGAALLLEGGVPAGVRTCAAARVGRGDQQLWCGALDELEQAGLGEPPHSIVIPGELHFVE
EEALAALQE
>A0A871BEG0|diphthine synthase|EC 2.1.1.98|Haloferax gibbonsii|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDDHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>T1CV55|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
MGELCFVGLGLRDERDLSLRALETLRGCHRVFLEEYTSRSTPGTVERLEALLGRPVELLD
RADVEAETPILSALAAQEKVALVVVGEPFAATTHVSLRLAAQDHGHRWKVLHNASILTAG
PSLAGLSLYKFGRTCSLPTPHENYRPRSPYEVLAQNTRAGSHSLVLLDLDPGASRYLSAP
EALRLLASLETEWHEGVLPPGRRVVALARVGSDDPQVVVGPWEEVSRADLGPPLHALILP
GEPLHFIEEDALSRWPRAPPGPPVGGALP
>A0A832TR51|diphthine synthase|EC 2.1.1.98|Methanosarcina sp|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKIQLLSRE
DVEQHPDWLDNAIDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSALGLHTIVFLDIDKEKGYMTV
NLALELLLEVERKRGEGVMDGVVSVGIARAGSEKPVVKADYAEKLKGFDFGNPLHILVVP
GKLHFLEAEALVKLAAGPEEIMENIE
>A0A7J4KAP0|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon|TrEMBL
MLTFVGLGLYDLEDISVRGLACIRNADHVFLEYYTSRLAGCTLEAMESFYGRPVQVLSRT
DVEVDPGTMLSHAATSDVVFLTGGDPMVSTTHIDLRIRAHQQGIPTRIIHASSISTAVCG
LTGLQNYRFGRSCSLPFPHGTWFPTTPIEVIGANRARDLHTLVYLDIQEERCMTIPQAVG
LLEELGARTGTSVPLYVGVARAGAECPVVRAGSARTLAATDFGPPLHILVIPATLHVMER
EYLEIFGGL
>A0A7K4EV82|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFIGLGISGFKSIPNEALEILSKADIVYLEQFTSPIGKSDLMKIKKATSGEFKLAKRW
LVEDGSEILKNAKKKKVALLAYGDPYIATTHIELRTRAIEEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALNG
LLETEKGQIRNVISLATYVIVASRIGFKDQSIISGKISSLKKINFGKPPHTVIIPGRLHF
TETDALKLFGQCIDEPFDNTEKTKKISIQMMKK
>A0A524LU46|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGLGISGFKSIPIEALDILSKADIVYLEQFTSPIGKSDLAKIKKATNGEFKLAKRW
LVEDGSEILKNAKKKNVVLLAYGDPYIATTHIELRARAIEDKIKTRSIHASSSITSMIGE
CGLHFYKIGRIATIMSAMKSLTTPYYVVYKNVIEGNHTILLLEYNQDKDFFLDPKDALRG
LLETEKGQIRNVISPSTYVIVASRVGFKDQSIISGKISSLEKTDFGKPPHTIIIPGKFHF
TESDALKIFGQCVDEPFDNTEKTKKISVQMMKKYVPMVREALEEVVPLYKGQKEFQVILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A7J9QWY1|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPISKSDLTKIKKATKGEFRPAKRW
LVEDGTEILDNAKKKKVVLLSYGDPYIATTHIELRERAIKDKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNG
LIETEKGQRRKVISSSTYAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNAEKTRKISVQMIEKYVPMVREALEEVQPYYKDQKEYEVILE
NAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A371LK53|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-16N|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEYVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVESDALSALGGAPEELFDDEN
>A0A0E3NYE1|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. MTP4|TrEMBL
MLTFIGLGLFDEHDISLKGLEAVRAADLVYAEFYTSYLMGTTPEKMEELYGKEVRLLSRE
DVEQQPDWLEEAKTKNVVFLTGGDTMVSTTHVDLRLRAKKLGIETRLVHGASITSAVSGL
TGLQNYRFGKSVSIPHPYESKRGVLVITETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NRALDLLLEVEKRRGEGVMTRAVAVGIARAGSKLPVVKADYAEELQNFDFGKPLHILVIP
GKLHFLEAEALVELAGGPGAILKEAE
>D2RG07|diphthine synthase|EC 2.1.1.98|Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)|TrEMBL
MLIFVGMGLWDERDISCKGLEIARKADEVYVEFYTSKLMGTNLERIEEFVGRKIVELSRS
DLEENCVWIIERAKERDVVILIPGDPMIATTHSALKYEAERRGVKTRVVNAGSIINAVCG
LTGLHNYKFGKSATVSWIKSKTPIDVINQNLSINAHTLLFLDLHPKPMTIKDAVEILMDV
ESGVGDLFAVGIARAGSENPVVKCDRMKNLKDYDFGEPLHVMVVLAKLHFMEFDCLRLFA
QAPDELEEIVE
>A0A520KYT2|diphthine synthase|EC 2.1.1.98|Candidatus Methanolliviera hydrocarbonicum|TrEMBL
MLTFVGLGLYDEKDISLKGLCAVKNSDYVFAEFYTSRLMGIDIKGLEKFYGKDIHELKRE
DVEIHAEKIIEKAKRDDVCLLCGGDPMMATTHVDLRMRAEDAGVETKIIHGSSIQTAAIG
ICGLQNYKFGRSSTIARPYKDKVPETPYDVLKNNLKNNLHTLFFLDLSEDLSEAPMTIRE
GLEILLNIQERRREEILDIGIGIARAGSEDMEVKADFIEDLMEYNFGPPLHILIIPAKLH
FMEAEALVKFARGPKEILER
>A0A2U1S7M6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter woesei|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFGAIENLIGKEIEVLVRG
EVEEESKFIEEAKDNDVALITGGDPLIATTHSEFLVQCAKKGIKYEVIHGSSILSSAPAI
SGLQAYKFGKVTTIPFPDYNFYPKSPYEAIEENLHMDMHTLVLLDIQAHKERYMSVNEGL
EYLMNIKNDLDHEGLITEDTLAIGIARVGSKDVVVKAGSIGDLIDFDFGEPLHCIIIPSK
LHIVEAEYLVEIAGANPDILNEI
>A0A848D9H5|diphthine synthase|EC 2.1.1.98|Candidatus Ethanoperedens thermophilum|TrEMBL
MLTFIGLGLYDEKDVSLRGLEAIRSADKIYLECYTSLVTGTNIKQLEKFYCKKVHLLERE
DVETNNWWLKDAISKNIVFLTGGDAMVSTTHIDLRLRAKKLGIGTRIIHGASIISAVCGL
CGLQNYRFGKSATIPHPYTRKEKIIRSHTPYDTIELNQKNNLHTLIFLDIDKNIGCMSIN
QGIELLLQVEEETGGEAISNCIGVGIARAGSFAPVVKADYLENLKHVDFGDPLHILCIPA
NLHFIEAEALIVFADAPGNILNQSNSFEEFNLYERK
>A0A329TDC7|diphthine synthase|EC 2.1.1.98|Halorubrum sp. 48-1-W|TrEMBL
MLTFIGLGLYDERSITVEGREALRTADRVFAEFYTSRLVGADVADLEAAHGVDVEVRDRE
GVERDPEPILEAAEAGDAAFLTAGDTMISTTHTDLRLRAETRGIDTRVVHGVTAQSAASS
LTGLQNYRFGKAVTLPFSYAHGGDDVPGSVIETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADHAARLLAEGWRDELAVVVARAGSPDAVVAADRLSALAGREFGDPLHLLVI
PGDLHHVEAEALVGLADAPESLLEE
>A0A6A9T452|diphthine synthase|EC 2.1.1.98|Halorubrum sp. CBA1125|TrEMBL
MLTFIGLGLYDERSVTVEGREAIRDADRVFAEFYTSRLVGADVADLEDYHDVEIEVRDRA
GVERRPDPILDAAVEGDVAFLTAGDTMISTTHTDLRLRAAERGIETRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADYAAELLAAGWRDELAVVVARAGAPDAVVAADRLSALAERDFGEPLHLLVV
PGDLHHVEADALTGLAGAPADLIEE
>A0A4V6YC65|diphthine synthase|EC 2.1.1.98|Halorubrum sp. GN11GM_10-3_MGM|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRD
GVERDPEPILDAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGRD
PDHEEYMTADVAAGLLAAEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLIAI
PGDLHHVEADALAGLAGAPESLVEE
>A1RY11|diphthine synthase|EC 2.1.1.98|Thermofilum pendens (strain DSM 2475 / Hrk 5)|TrEMBL
MLVVAGLGLCGTRDISVGLLREAEDADEIFLETYTSVSPGLRVEDLVSVLGRGVKLVTRK
DLEDESARTVLEVAARGKALLLTIGNPLIATTHSSIVVEAAKRGIKVRVLPAPSIIDGII
ASTGLHVYKFGRVVSLVFPEDPSLKNYPYTPYSVLKDNVSRGLHTIFLLDIRADEGRYML
FREASELLLRLEERFQENVVDENTLVIGVARATAEDEKVFAGRISEAINADLGNAPHTLI
VPGELHDSEIDFLHYKTGRPVEVFKSWNAKVNAKKKQSGTSPTWREP
>A0A832TRS6|diphthine synthase|EC 2.1.1.98|Methanoregula sp|TrEMBL
MLTFVGLGLFDKTDISVKGLRCIERADAVFLECYTSRLMGTSIEELEQFYQKPVRPLFRE
DVEQHPDGILALAQEKEVVFLCAGDPMVSTTHADLRIRADERGIPTAIIHAASISSAICG
LSGLQNYRFGKSCSLPFPQKNWFPTTPFEVITANLAQRLHTLVYLDIQNERYMTIPEAVA
IIEKIAKDRQTKIPLYVGIARAGSDAPVVRAGPADRMLSAEFGAPLHILIVPAGLHDMEK
EYLERFAGL
>A0A075FNS1|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote AD1000_29_E08|TrEMBL
MTADAIEHARACEHRFLEGYTATLPSDQESRLESLIGPWQRAMRPEVEKPSEILELARNS
PVALLVVGDPMQATTHIDLEAHCDEQSIEFSVIPGLSATSLAVSLSGLQSYRFGRQVTLP
FAYGDYLPTSPLELIDANYRSDLHTLVLLDLDPTGMGVDEPQPMRPAQAVELLQKMAERL
TEREGDTRDSMSIPLAQWDSILLSDLGTPDQRVVSGNLEDIAKVDGGRIHCLILPAEFSG
LEREAYERRKGQR
>A0A1I3BGJ6|diphthine synthase|EC 2.1.1.98|Halorubrum aquaticum|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSRLVGADVDDLEAAHGVDVEVRDRE
GVERDPEPILTAAETGDAAFLTAGDTMISTTHADLRLRAESRGIDTRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGGDDVPSSVRETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADYAAGLLADGWRDELAVVVARAGSPDPVVAADRLSALAEREFGDPLHTLVI
PGDLHHVEAEALVGLAGAPESILEE
>E0SPF8|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)|TrEMBL
MLRFIGLGLSIDNIPIGNLKKLFECQKIFIDSYTSIWFPNIDLLVDILVKSGKSVVVARR
DDLEGSAIRRILSESRDYDICIATPGDPFIATTHSAILSEALRMGIAVEISPSSSIVNVG
ISMSCLQIYRFGKIVTVVRPKNGIVYEYPFDVLKLNRELNLHTLMLLEIDVENNYYMNPR
EAIEILLEIQRMRGEEILGKDDKIIVLEALMSSSGRIYIESVESILRRSPDEYRFYPYTI
IIPARVLHPIERECLENIDRVLYIHSINEKELLNIASYIFR
>A0A1Q1FLV7|diphthine synthase|EC 2.1.1.98|Halorientalis sp. IM1011|TrEMBL
MLTFVGLGLYDERSITVAGRDRLREADRAFAEFYTSRLVGTSVPDLEAHHGVDIEVRDRA
GVEQDPDPILDAAADGDAVFLTAGDPMISTTHVDLRLRAHDRGIDTRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFERAHGGSGVPDSVVETVADNADRGLHTLVYLDIKAADDEYMTA
DTAADLLADEYDERLAVAVCQAGSSDPTVVADDLSALADREFGAPLHLLVLPGDLHLLER
DALVELADAPVDLVENWTV
>A0A2R6K6E2|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_9_67_17|TrEMBL
MLSFVGLGLWDERSITVEGREMLQDADRVFAEFYTSRLMGTDAASLAAHHDIEIEVRDRA
GVEQNPDPILDAAEDGHVVFLTAGDTMISTTHVDLRLRAHERGIDTRVVHGTTASVAAAS
LTGLQNYRFGKATTLPFPYAHGGEGVPASVSDTIDANRERGLHTLVYLDIKQTRGEYMRA
DTAAGLLADGYEDTLGVAVCRAGSPDPRVEADRLSALAERSFGDPLHLLVIPGDLHHVEA
DALRTLAGAPDGLTEPR
>M0K8T3|diphthine synthase|EC 2.1.1.98|Haloarcula sinaiiensis ATCC 33800|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLENTLETSIERRDRA
GIEQDPEPILEAAESEHVVFCTAGDTMVSTTHADLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEES
DDTYMTASQAATMLSEPFPDTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPG
SLHPLEADTLESVAGAALE
>A0A2H1FFL3|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotalea okcheonensis|TrEMBL
MLWFVGLGISGLDGTSVNAIQVLKKADMTFFENFTSPIGKSEVLKIKKLVKGKLTIAPRW
MVEDGKAILALAKKKNVVLLAYGDPYVATTHLELRTRAEKDKIKTKTIHNASAITSLIGE
CGLHHYKIGRPVTIMRETPSLTTVYHTIYENMIKGSHSLLILEFDNSSNFFMNPKDALYS
LLETEKGQKRNVIDQSTFAIVASRIGAKNQKIISGKLLTLVKADFGKPPHTIIIPGKLHF
TESDAIKIFSQCLDEPFDNSSKIQKISDQMLSKYIPKARKALEEVVKMFKNDTSLGPVIE
NAQLYIDDAEKFQKDGQEELAVLSIGYAEGLMDALRLSRGIDPWTQSL
>F2KPA2|diphthine synthase|EC 2.1.1.98|Archaeoglobus veneficus (strain DSM 11195 / SNP6)|TrEMBL
MLTFIGMGLWDEKDISLKGLEEAKKADVVCVEFYTSRLMGTSLERIEELLGRKIRVLERS
DLEENSGALIEEAKTKNVAILVPGDPMVATTHSALRLEAEQKGVKTRIIHGASISSAVCG
LTGLHNYRFGKSATVSYPYGKPSATPVNVVHANWSVDAHTLLYLDLHPEPMLISQAVEIL
RSAGLEDCFAVGIARAGSDEPVVKCDTLEKLKNHEFGEGLHIMVILAETLHFMEYECLRA
FASAPPELERLVK
>A0A3R7J2Z5|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Atlit-8R|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAYHGVNVEVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAADLLAEGWADELAVAVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLADAPEALVEE
>A0A1V4YMQ6|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. PtaU1.Bin097|TrEMBL
MLYLIGLGLYDEQDVSLKGVEALKKADVIYAEFYTSRLFQGSIKSLEYKLGVQINVLKRE
EVEEENIPLKEAQDKDVAFVCAGDPLIATTHTDLMIQARKRDIETTVIHSSSILTAAPGL
AGLQAYKFGKVTTIPFTEENYFPHSPYLAIRKNLEEKLHSLVLLDIQAHRDRYMTANQGL
EYLLQVEEKRNEGIITGDTLAVVVARAGAEKPVVRADIISKLVDEDFGGPLHCLIIPSDL
HFMEAEALVVLGGASLSILQDSI
>A0A8J8IXW8|diphthine synthase|EC 2.1.1.98|Thermococcus sp. LS2|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTRIEKIEELIGKPIRLLNR
EEVELHFERIVLSEAKNKDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
SITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTLLFLDIKADQGKYMTANE
AMEILLQVEEMKKQNVFTPETFVVVLARAGSLTPTLKAGYVKDMIKEDFGKQPHIMVVPG
RLHIVEKEYLVTFADAPEEILRRRDL
>A0A523APG6|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLIFVGLGLCSHKGLPLRGLELARDSDWVYMEHYTSLLPELDLRELEGWVGKPVKVVDRQ
TLEENPEEILERARKGKVVLLVPGDSMVATTHVDLRLRAEKRGIPTLVVPSSSILSAAPG
LTGLQSYKFGRSATIPFRDHPSTVPYDTLVENSARGLHTLLLLDLRAEEGRYMTAGEGME
IMLELEARMGKGVFTPETLV
>A0A2U0RXH4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSELVFIGLGLYDEKDVSLRGLEELKEADTVFAEFYTSLMPGLCIKKLEDMIGKTIKVVS
RRVLEEEDGQQLFEAAKKGKAAFLVQGDPMIATTHVDLRISAEKRGIKTRVVHGASAVSA
VRGISGLQNYKFGKAVTIPFSEQGVVYETPYKVIHENMKMGLHTMCYLDIKAEEERYLTV
NEALQTLVELEKQKKQNVASPRTLVVGVARAGSPQPVVKAGYIEDVINHDFGAPPHTLIF
TGKLHFMEAEALIALADAPQEVLERAQ
>A0A256ZHL1|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon ex4484_204|TrEMBL
MGKLYLVGLGLASDLISLRALNVIRRARKVFIDAYTGIVLNDGLADVIGVKPARLSRADI
EDRNAEVLFNELERGDVALLVPGDPLVATTHIALAVEAFKRGHDIEVVPGVSIIPNALTI
SGLMIYKMGKVVTVTYPSHGLLYEYPYDVIRDNDSRNLHTVLLLDIDVERGVMMTVRDAI
NILLEIELRRGEKVIRPDRLVVAIAALGSRELMRVCTLRVSEAKSFKYPHGPQTLIITSP
KLHYMEEEALRVVNSVYCREL
>A0A537HQG0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLTFIGLGLNDEKGITLEGLEEARRADSVYGEFYTNIMPNLDLKRLEKEIGKKVEVLDR
SQLEDEGGKKVLTAASTERVAFLVPGDPLIATTHISLRLSLAKMGIASRVVHAPSIVSAV
CGATGLQSYKFGKSITIPRDQPLPRSVLDTISDNSDRGLHTLILLDVQAGKISQMTIRDA
ITKMTTADPRLEPRLAVGVARVGSKDERVKASRMKELIGEDFGVGPQSIVVVGRLHFMEA
EALELLCGASHDNLREPS
>A0A497K8P6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKELVFIGLGLSNEKDISLRGLEEIKSANKVFIETYTSLMPNLSIEKLEKLCGKKLETVS
RRELEEENGEKILSAAMHGKATLLVPGDPLIATTHVTLRIQAEKMGIKTRVVHAASIISA
AIGLSGLHNYKFGKSVTIPFPNDDYLSETPYYVIMENGNLGLHTLCLLDVRAEEKRYMTI
SQAIEILRKLEEKIGKKVISKGTLALGIARAGSDKPAVKAGTLIELENYDFGGPPHTLIF
PGKLHFMEAEALKVLAGASEESLKELVE
>A0A550H6U8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
VFIELYTSILPCFSMQRFEAFVNKQIHVVSRHDLEEEGGRVLLKAAEKGKAVFLIPGDPF
IATTHVALRIEARKRGVKTRIVHGASVMSAIIGLSGLHNYKFGKTVTIPFPENFSETPYN
VIAQNKKLGLHTLCLLDIKTDEKRFLSISEALMLLLEIEQKRKEGVITQDTIAVGVTRAG
SKAPTLKADFVKDIVKFDFGDPPQSLIFPGDLHFMEAEALVTLAGAPERLKRLGK
>A0A497KQH4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVFIGLGLFDERDISLRGVEEAGDADFVFAELYTSLLAGFSLRGLEQIIGKDITVLDRRA
LEDEDGELVLRRAERGKVAFLVPGDPLIATTHIDLRVRAEKRGIKTRVVHAASIVSAVMG
LSGLQNYKFGRSVTVPFPENGVVSETPYWVIAENKRRNLHTLCFLDVKAEKRRYMKVREA
LEVLLSLEEKIGEGVLTSRSLAVGISRAGAEDGVVKAGSVKDLMVFDFGDPPHILVVPSE
KLHFMEAEALCVLAGAPGWIKGMIK
>A0A7J2K0L9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
AVVGLTGLQAYKFGRTTTITYREAGLLSEAPYRAIAENSARGLHTLCLLDVRVEEGRFMT
IREGLELLLELEEERGEGLLGPDSLAVGIARAGSEEPVVRAGTIEQLLEQDFGPPPHALV
IPGELHFLEAEALKVLAGAPDWVGKRAVPSESGGPLRGARRAKDLAGKYVSNLEFAFSTL
SIKDKKAVGQEELEYVLDMARRYKEDAESFSERGEHITSIAAASYAEGLLDALRLLGLVD
FAWPS
>A0A7C5N7D2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVLGELVFVGLGLDDEKGISLKGLEEAETADAVFIESYTSLMPNFSIENFKRLVGRAVQF
VSRRQLEDEGGKAILEAAEKGKAVLLVPGDPLIATTHLALRLEAEKRGIKTRVVHGASIV
SAVMGLCGLHNYKFGKSVTIPFPENFSETPYTVLAQNMRLGLHTLCFLDLDVEKNRYLTV
RKALEMLLRVEEKKRNEVVTGETLAVGVARAGSVNPTVKADFVRELLSYDFGGPPYSLVF
PGKLHFMEAEALIAFAKAPLSVRRLVE
>A0A550GR48|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
KKLGLHTLCLLDIKTDEKRFLSINEALMLLLEIEQKRKEGVITQDTIAVGIARAGSKAPT
LKADFVKDIVKFDFGDPPQSLIFPGDLHFMETEALVALAGAPERLKRLGK
>A0A1Q7P7C0|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_40CM_2_52_14|TrEMBL
MSVTFVGLGLNDEKGLTVEGVEVARKADAVFAEFYTNLMPGLELKKLELLLGKKIVVLDR
VQLEDENGRRILEAAGKGRVAFLVPGDPMIATTHVSIRLELAKRGVSSRIIHGPSIASAV
CGATGLQSYKFGKTVTMPQESGVPGSLVDGIMDNRKRGLHSLVLLDIRSDLSKQLTVAEA
ALKLVAADPLIENWLGIGVARVGSPDQFVLARRLGGLQREDFGKFPHSLVIPGRLHFVEV
EFLKVFCGAKDTDLESVK
>A0A650CN46|diphthine synthase|EC 2.1.1.98|Stygiolobus azoricus|TrEMBL
MSLLKLIGLGLSSKFITKKAIEELSSSDIIYLDSYTSLSCDINEELISSLTGNNVRVLSA
NRPLLENNFEIILKYLDEGKNIAIATIGDPMIATTHISLITEAKSRGHEFLIVPGVSVHC
YMISKSMLSSYRFGKSVTIVYPFGDKIDMTPYYVLKENQERKLHTIFYLDIRDGKPMSAK
EAVSLLLKMEETEKMKVISRDDVIIVGQRLGCQDEEVVAMKLSDVVNYQFKPQPHIIVYP
SKSLHFMESEGLKCLMKR
>A0A5J5LL87|diphthine synthase|EC 2.1.1.98|Haloarcula hispanica|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A5B9M4E9|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp. KEPCO-1|TrEMBL
MLYIIGLGLYDENDISVKGLKALKACSRVYAEFYTAILQGASLSAIEELTGKDIDILRRE
EIEEERIPLLEAEKSDVALLVPGDPLVATTHTELILDARRRGIETRVIHASSIISAAPGL
AGLQAYKFGRIITVPFTSENYFPTSPYVNIRDNLERDSHSLVLLDIEAHKRRYMTANEGL
EYLLRASEKLGDDTINEKTLAVVIARAGSERPLVRADAISSLIKEDFGDPLHCLVVPGAL
HFIEAEYLVEVAGAPRSIVEGMII
>A0A534L358|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGELVFIGLGLDDERGITLRGLDEARAADLVFAEFYTSTLPGASIEAVEKLIDRQIRRLS
RKEVEDGQVLLAAAATRTVAFLVPGDPMTATTHVDLRLRAEASKIRTRIVHGVSILTSAA
GALGLQAYKFGRTTTVPFSSTGFAPTSPLEAILENRRAGLHSLVLLDLREDGSFLAPRDA
IASLLRMASAVGTSEFGPQTLACALSRVGSPQVRAFAGPVADLADRDLGPPLHCLVVPGA
LHFLEKEALVAFAGAPHDL
>A0A662U437|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLIFIGLGLNDEKDITQRGIEAAKKSEEIFVELYTSPMPNINIQRLEDTIGKKIRVLSRE
DLEEKSKTLLELARRCVVAILTPGDPMVATTHLALRLQAEQMGIKTRVIHGPSIVSAAPS
FAGLHVYRFGPPTTIPHPSPSYRPTSFYNTITQNQARGLHTLLLLDVNHEKKCYMTIPQA
IEQLLEIDKEKILENRILVGIARVGSNKPELR
>A0A8J8G350|diphthine synthase|EC 2.1.1.98|Nanoarchaeales archaeon|TrEMBL
MLHLIGIGYKKENLSYEMMEIIKNADEVFLEXYTSFYQDSFEELEKFVGKKITVCDREVI
ESQIEXLILKPAKDKTIALLVIGDPLIATTHTDLLLRCHDLKVKSKVYNNVSIGNFITRT
GLQFYKFGKITSLPFYSEKFMPRSPFMVHLDNHKMGAHSLFLLDLNPSDDVAYKGHSKYL
KAHEAIEFMLRIPKLMVEEEELEEKDASIVDEDTPAVICSRLGFDDEEIVFDTLGGLAKM
DKVTLFREPLCLIIPGDMHEMEERYLKTFHS
>A0A327HL32|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MSAENKKFSNGLWLIGLGPGNPDLFTIGGVEAIKNCKHVFIEGYTANLQNIDLQELEKRF
GKWKTLMRNEIEKPDKLLTLASHESVALLIIGDVLQATTHIDLILRCQKLNIPINLIPGI
SITTLIGEVGLQAYRFGRQTTIPYIYKSYLPTSPLEVILTNKKNNLHTLVLLDLDPTGMG
EDKPQPMTPFIAIDTLNSMSKKLKINGEQMDSDMMSWNAVLCSNLGTSNNQIRYATLRDL
SEVKLDGMHCLIIPSKLHEIESLALRRWEVD
>M0I789|diphthine synthase|EC 2.1.1.98|Haloferax sulfurifontis ATCC BAA-897|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADCAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWGGDALGVAVCRAGSPDPVVAADRLSALAERDFGDPLHML
VIPGEIHHVEADALSALGGAPEELFDDEN
>A0A7K4MQU2|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQKADFVYLESFTSPIYKQQEEEIKNIVSGSFKIAKRW
LVEDGQEILKASKSSTVVLLSYGDPYIATTHIELRTRAKLEKIETNTIHSASAITSMIGE
AGLQFYKVGRIVTIMNEKKSVITPYTSIFKNLIQGLHSVILLEYNQDENYFLDPKDAISS
LMDVEKEQKRNVVNNDTFAIVASRIGFETQKITSGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKSSDNSTIIKSVSVQMIEKYVPMVREALEEIKPLYNDSKEFQVVIQ
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKI
>A0A497I6F4|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MTVMLYLIGLGVDFDLGVKALNIVKKADRVYLESYTSPVDFSVIDSYGFNYDVLSREQIE
EEFNVLDAKEKDIVILVPGDPLTATTHISLILEAYEKKVPYKVIHASSVYTAVCETGLQI
YKFGRSTTMPATGEKSFYTVIEENMSLGLHTLVLVDPELDSKQAIEMLLSMGFPSDYKIV
LASKLGYDSTIYYGKASDLAADVDKPFCIIIPGKLHFMEQEFLDKVYKYNSVK
>A0A7J4IWF3|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MLCLVGIGLYPGQLTLEALSALRECEKIYLENYTSSYSQGSIDKLKELTGKEVATLARRQ
VEEELTPVIEEARTKKIALAVFGSPLNATTHVQILLDAKKMGVQTKAIAGISIFEYVAFT
GLDRYKFGRTTTIVFHGENYEPESFYDTIAQNKKAGLHTLCLLDIQAENEKMMDVRHAIS
LLEMIEEKREESAISESICIGIAGAGSDGSQIKAGTLEQLKKFNFSIYPQSLIVCGKINE
KEGEALRALSDLQ
>M0NRB1|diphthine synthase|EC 2.1.1.98|Halorubrum kocurii JCM 14978|TrEMBL
MVAADSLSALADREFGAPLHLLVIPGDLHHVEADALAGLAGAPADLVEE
>A0A8J8PM96|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. B5|TrEMBL
MGVLNLVGLGLAKKFITKSAVDALLNSDFIFFDRYTSKSCDINTDSLKEILNGKDVIEAN
RDLLENNSKIMLNYLDNNYKVSIATIGDALIATTHVSLALDARKRGHIVNVIPAVSVHCY
IVSKSFLSSYKFGKSVTVTFPYDNFIDYGPYHVIRDNKERGLHTIIYLDLKDGKAMTAND
ALNILLSMEDKHRMNVISKSNIVIVGARLGCENEKVIAMTVEEALNYDFGDTPHIIIIPG
TLHYMEADAIKWMLMT
>A0A7C4NMU9|diphthine synthase|EC 2.1.1.98|Staphylothermus marinus|TrEMBL
MLIFIGLGFAPQHLTLEALNHIVKCDKIIIDTYTGIIQEDYIDTIKPLLKGKEVVYAKRR
DLEGSSIEKLVAEAKNRDIVVLVPGDPFIATTHDAIRAEAGRRGVKVKVVNGLSIVNLAI
TKCGLQIYRFGKVITLVFPEITKPYSVIDTIYDNLNRRLHTLVLLDIRVEEGKYMGIGEA
VDILIDMDVENRLANTIGIGLERLGFRDEKVIADLLPSLRKYRFHKPPHSLIILSEPHPI
ELDCLLHYCNLPLNVYLDFSSRRKRG
>A0A498GC50|diphthine synthase|EC 2.1.1.98|Halobellus sp. Atlit-38R|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAVAEFYTSHLVGATVGELSAYHDIDIDVRDRA
GVEQHPEGVLDAAEDEHVAFLTAGDTMISTTHVDLRLRAIERGIDTRVIHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVVDSIEANRERGLHTVVYLDIKAEREEYMTA
DVAAEMLAADWQDVLGVVVARAGSPEPTVVADRLSELATEDFGDPLHLLVIPGDLHHVES
DALATLGGAPADVLEANEV
>A0A6B2C5B3|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon|TrEMBL
MDNPSDACRGELYIVGIGLHPKMLTLEALEAINKADSVYLETYTSPGVDEMTSFLEKIRF
GEKITRLTRKDIEEQGAREIINKLRNGEKVCFLVYGDPFVATTHNALRLEALRLGCRVNY
VPGISVYHYSISATGLFNYKFGPSVTVVYPRWGIKFTSPYMTINENLERGLHTFVFLDID
EKLGPMTPDIAAKLLLEASTEFEKRNLNENSVVLVLERMGGPNEKIYCEKLGGLPNKRWG
APPYSLVIPSKLHFMEKDVLLSIGLGCNKLF
>A0A151E8I5|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon SM1-50|TrEMBL
MSKGHLVFIGLGLYDEADISVKGLQQLKACDMVFAEFYTTMLGMFDRKSFEHLIGKQIRV
LSREETEKGDQIIDAASQNHVAFLTGGDPMIATTHVDLRLRAIQQGIPTTIIHSSSIVSA
VPGLLGLQNYKFGRITTLVFPEKDYFPTSPYTVICANKNMGLHTLILLDIQAEKDHYMTA
NQGFELLLRMEEKLKKNILTNETLACVVARAGAENPMIMANTIGALQKKQYGPPLHTIVI
PGDLHFMEIEALELCAGLPSEIKRKIQKL
>A0A075FNC8|diphthine synthase|EC 2.1.1.98|uncultured marine group II/III euryarchaeote AD1000_10_C12|TrEMBL
MTHHTRKSDKHYSLDDDGGWTMTNFESGLWLIGLGPGDLSAMTTASIEAAKSCNYRFLEG
YTALLPSGEGAKLVEIVGEYELLMRPEVENPDQLLELASENAVALMIVGDPLQATTHVDL
QLRAKAAGINCHVIHGISITTIVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNL
QRDLHSLVLLDLDPTGMGIDEQKPMSPAMAVDILRRSADKIGENIEQWKIVLCSDMGRPE
QRIFYGTLDDVESINNGSIHCIVIPGRLDELEVEALARWN
>A0A520K9S6|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLALIGLGLDGTEISAKGLSYVAGSDEVFAEFYTSLPCVDMAEIERIVGKPITVLTREDV
EERELPLERARTCTVAFLVMGDPLVATTHISLAARAREDGIPLAICHASSIYSAIGSTGL
MLYKFGKSASIVYPEKNYFPKSFYETIVQNKKRGLHTLLFLDLKADRDIYMNPVDGMRLL
RAADEETIVSTIIVASRIGWKSEKIVYGEVSELSSLDASFFGPPPHCIVVPGEMHFAEEE
YVELFRYG
>A0A1E7GCU3|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. Ant1|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIRGADLVYAEFYTSCLMGTNLNEMEKLYGKKVCLLSRE
DVEQHPDWLIEAKDKNICFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRVISETPYDIIKQNAEMGLHTLVFLDIDKEKGYMTV
NTALKLLLEVEEKRGEGFMHNVAAVGIARAGSEKPVVKADYTEKLKDFDFGKPLHILVIP
GKMHFLEAEALVKLAGGPTGLMEEVE
>A0A497RM67|diphthine synthase|EC 2.1.1.98|Archaeoglobales archaeon|TrEMBL
MLIFVGMGLWDEKDITCKGLEIARRSDEVYIEFYTSKLMGTNLDKIEKFIGKKIKMLERS
DLEEKSRWIVERAKDRTVTILTPGDPMIATTHSSLRLEAEKRGIKTKIVNAGSIINAVCS
LTGLQNYKFGKSATVSWMKSRVPLDVIMQNLSINAHTLLFLDLHPKPMTIRDAINILVDT
GDVGELFAVGIARAGSENPVVRCDRLERLKSYKFGDPLHVIVVLAKLHFMEYECLRVFAH
APEELEEIVE
>A0A843JZK6|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MLYLIGLGLNEKSLSKEAIEIIKRCKKVYLEDYTVDFPYTHQALIDEIGKKFVTADREKV
ESLEIVDEAKKMDVALLVYGSPLTATTHITLIEEAILSGIKYRIINNASVLDGIVETGLQ
IYKFGKITSLPEWKKSYEPDSFMEIVKENQSIKAHTLLLVDIGLDIKKAIEQLEKAAKKH
NFKLFKLIICQALGTKKQKIIYKDLEKIKEFTNVQKPYCIIIPGELHFMEKKMLEGFS
>A0A0E3LLD7|diphthine synthase|EC 2.1.1.98|Methanosarcina barkeri str. Wiesmoor|TrEMBL
MPESIQTKSFKPAGLLKRTMLTFIGLGLFDEYDISLKGLEAIREADMVYAEFYTSCLMGT
NLEKMEKLYGKKVFLLSREDVEQHPDWLSKAKNRNLCFLTGGDTMVSTTHVDLRLRAEKL
GIDTRLIHGASIASAVSGLTGLQNYRFGKSASIPHPYESRRGTRIISETPYDTIKQNLEL
GLHTLVFLDIDKEKGYMTVNTALELLLEVEEKRGEGIMRGAAAVGIARAGSEKPVIRADY
AENLKDFNFGKPLHILVIPGKLHFLEAEALVKLAGGPVGFMKEVE
>A0A7J4PSF6|diphthine synthase|EC 2.1.1.98|Methanotrichaceae archaeon|TrEMBL
MLSFVGLGLYDEKDVSVRGLETIKDADLVYAEFYTSRLMGVSPERLEEFYGKDVHLLRRE
DVEVSPDEWMSQAGEKKVAFLVGGDPMISTTHLDLRLRALKMGIETRVVNSSSIVTAVSG
LTGLQNYRFGRSTSIPYPYVARGNRIVAQSPYDVVVENLERNLHTLLFLDIQVNRYMTAS
EGAKLLLEMEKISGGDRLSAALGVGVARAGSDDANVLADWLPKLAEHDLGGPLHILVVPA
RLHFMEAEGLVALAKAPEEILKAAES
>A0A7L9FIR8|diphthine synthase|EC 2.1.1.98|Infirmifilum lucidum|TrEMBL
MISPRQGLGLLIIGGIGLWGLRDVSVGLIEALRSSDYIFLEEYTSITPSFSKTELEKVVG
RRIDLLKRVDLEGSHLREILELAKEHRVAILTHGNPFVATTHAYIVSEAYRLGIPLEIYP
APSVIDAILCSTGLHVYKFGRIATLVYPDERAGFFPYTTYRVLGDNLSRGLHTLLLLDLR
VEEGVFMSIPEAASLLLRLEDKFRENIVEPTMLVIGVSRALSPEEDIFIGTLEEATTLEK
TSPPHSLVIPGVLHDTEIDFLHYKTGVRKEVLISWSDYVKRKLRST
>A0A8J8CST4|diphthine synthase|EC 2.1.1.98|Halorubellus sp. JP-L1|TrEMBL
MLTFIGLGLYDERSITVEGRTALRDADRAYVEFYTSRLLGATVDDLERHHDVEIEVLERA
DVEQHPERVLDAAERDSVAFCTAGDTMIATTHTDLRLRAHDRGIDTRVVHGVTAETAAAS
LTGLQNYRFGKATTLPFEYAHAGSDVPDSVLDTITDNRARGLHTLVFLDIKVGDDTAGAD
ERDGDEYMTADHAASRLAAHHPDTVAVVVARAGSPTPLVQADTLQNLADRDFGDPLHLLV
IPGDCHLLEADALEALADAPRDQLDVA
>A0A7J4ID87|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLVGIGLNDEKDITVKGLEAIRGCDAVYLENYTSIMACGIAQLEKFYGKKVIVADRK
IIEHGDGIISAAATKNVALLVIGDPWGATTHIDIMMRCRAKNIPFTVINNASIITAIGIT
GLQVYKFGKTTSVPYPDKNFRPETSYEVINQNRMLGLHTLLLLDIRQDLGKFMTVSEAID
VLLEIESRKRQQVFTQDTFCVGCARVGSDRFVIKAASAKELKNYDFGKQPHCLIVPGELH
FVEEDALKQWK
>A0A842UW69|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALYLIGIGLDNEKDITLKGLEAVRKCKDIYLESYTSKLNCPTTKLEKLYGKKIFPADRE
LVEKEAEEKLLKPAKKQDIALLVIGDPMSATTHTDLLLRAKKMKIRTEVIHNASVLTAAG
ITGLELYKFGKTTSIPFHDKGFEPETHYDVLKGNQNMGLHTLFLLDLKPEQGRYMTVNQA
IQSLLEIADKRKDAVFSKDTICIGCARLSSKNQKIISGKAEKLLKKDFGKPVHCLVVPGK
LHFIEEEAVKNWK
>A0A7J3RCH6|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLIGLGLGWKDISLKALECLNNCEAIYLESYTSISDFSLLQLQRLIGKQIQPLERKDV
EEMFFLESAATRNIALLVYGDPLAATTHQEILFSAKKKSIDVKVVHAPSIFTAVSQTGLS
LYKFGKVASIPFSEPGFEPESYFDVLVDNLKIGAHTLFLLDLKPKENKFLTIPEAIEALL
KIDVKRKANLFTKNKLVIGCARLGFEDPLIKFGTAEELSKVDFGKPPFCLIVPAELNHKE
AEYTKLFS
>A0A7J4LX54|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGIGLSDAQDITLKGLETIRKCHSVYLEGYTSLMSCSIDELEKVYGKKIVFLKRE
DVENEREKITLEARTHDVALLIIGDVFSATTHADIILDSRKKNVSVKVIFNASIMTAIGI
TGLQLYTFGKTVSIPYPSKGFAPDSFFEGFLENKQRGLHTLFLLDIKADEGRYMSVPEAI
ALMIAAAEKRKNNGFTKQTLCVGCARLGCGDMLIRSGTAEELRGMDFGKPPHCLIVPGDL
HFIEEEMLEIWKG
>H1KY91|diphthine synthase|EC 2.1.1.98|Methanotorris formicicus Mc-S-70|TrEMBL
MLILAGLGLYDEKDMPLKTLEFAKKVDKIYAEFYTAILTGTTIEKIEETLGRKIEVLSRE
KVEYETEKLIEEAKEKDIMFLTAGDPMVATTHVDLVVEAKKKGIEVVIINAPSIYSVVGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKENLKMGYHTLCLLDIHADKNKFMTANEGL
KILLELEKRRKENIISENTKVVVVARVGSLKPKLVYGKIKDLIDYDFGEPLHCIIIPGKL
HFMEEEALKYLCENV
>A0A6A8G6I5|diphthine synthase|EC 2.1.1.98|Haloferax marinum|TrEMBL
MLTFIGLGLFDERSITVEGREALAAADRAFAEFYTSHLVGASVEDLESYHDIDIEVRDRA
GVEQDPEPILDAAAEENVVFLTAGDTMVSTTHVDLRLRAEERGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVESLEANRERGLHTLVYLDIKVDWEGRRGV
EVDGDEYMSADYAAELFAEHWDGDALGVAVCRAGSPNPVVAADRLGELATRDFGDPLHML
IIPGEVHHVEADALMALGNAPAELFDLDDR
>A0A497PGW7|diphthine synthase|EC 2.1.1.98|Thorarchaeota archaeon (strain OWC)|TrEMBL
YMTANEGINLILQMEEKTKKNILNKDSIICVVARAGSDNPVVAAGSISNLMDEDFGLPLH
TLVVPGKLHFMEVEALETLAQLPAQQG
>A0A4P9TDT6|diphthine synthase|EC 2.1.1.98|Natrinema pallidum|TrEMBL
MLTFIGLGLYDERSITVEGREALQAADRVYAEFYTSKLIGTTIDDLESVHDIEIEVRDRA
GVEQHPDDMLEAAERDDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKTEREEYMTA
DTGATLLAEEYPDLVGVVVARAGSPDPLVEAGTMSELAAREFGEPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A7C1WHR6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLSFIGLGLWDEKDITLKGLEEARKCDKIYAEFYTSRMGVEIKKIEKLIGKKIEVLSREE
VENGEKILKEAKSKNVCFLTCGDTMSATTHVELRLRAIEMGVKTKVIHGVSIVSACASLL
GLQIYKFGRVVSIVKPHKNYFPLSPYDAIKENMLMGLHSLLLLDTTDGLMTANEAINILL
EMEKRKKENIITPSTLIAVVARVSSPSAFSIADYIKNLVDEDFGKTPHSIVIPGKLHFVE
AEALVKISNAPEEIIKVKE
>A0A7K4FI68|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
ILDALARSTRVGFVTAGDPFAATTHVALRLAAERAGHTWRYVPNASIFIAASGFLGLMAY
RFGRTVSLPFPAPGFAPTSPVVEIGKNRSIGAHTLVLLDLHPSEGRFLAAGEAIRILLER
DPGHVGIAADREIAVVARMGRDTADAWVGPALELSRTEFGPPLHALVIPAPELHFAENEA
LARFRRPASPRS
>A0A842X8W0|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLRLVGIGLNPKKHITQEALEKIRNSDEVYLELYTSRIVDMSLEELENFLNRKIILLDRK
TVESNFLVERSRNLDVSLLVPGDPIIATTHIGLVILSIENGIKYEIINGISVQCVVPSIL
GLQNYKFGRSISIPFPEYDYYPESVYNFLLENRRLGLHTLVYLDLREGLEMSAIMGLDIL
LKMEDIHRKNALDRNTVVAVISRAGSDRQRATADTVERIKTRDLGPTPHIMVIAGTLHYM
EIEALRKLASFPDDQNVNL
>A0A4U7FD94|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SD626R|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVDELAAHHGVEIEVRDRE
GVERDPESILAAAAEGDVAFCTAGDTMISTTHADLRLRAEGRGIETRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGGDVPESVVETIETNRERGLHTLVYLDIKVGTGPSGPD
PDHEEYMTADIAAGLLADGWRDELAVVVARAGSPDPVVAAGRLSALADREFGDPLHLLVI
PGDLHHVEADALAGLAGAPAELVGE
>A0A7J4SCM3|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MDSSGLFLIGLGPGDLALMTRRAIDMLQDMDERYLEGYTATLPLAQENELENIVGPWKRA
MRPQIENPREIIEMAKSQKVAIMVVGDPMQATTHVDLLLRARENGVQVTIVPGISATTLA
ISSSGLQSYRFGRQVTLPYAYGDYLPTSPLRYILDNRLRNLHTLVLLDLDPTGLGIESPI
HMSPSVAGQILMQMAERWSEENEDVDVCAWNVVVLSDLGTDQSHVCSTVIKEMNGMDGGR
IHCLILPAEMDNHEQMVFDSMRYHA
>A0A8J8CDZ7|diphthine synthase|EC 2.1.1.98|Candidatus Sysuiplasma superficiale|TrEMBL
MGRLVFVGAGLNGVRGMTLDALSEISRADTVFVERYTTYLPDDFEAELLKRTGKRALPLS
RKAVEDGHAVLESSRKGSCVLIAGGDAMTATTHSSLRIAASRNGIDTVIVPGSSILTAAA
SYSGLQHYRFGRVVSVPRFTDSFMPDSVLDNIMFNLENNLHTLLLLDVDQEKGYYMQPAE
CFSQLLHLSSRRNPPPITGDTFACVVSRAGMEDCATAAGRISSLAERDFGRHPHSVIIPA
RLHFAEAESLVEFSGAVRDDINSLIM
>A0A1H5ZNX5|diphthine synthase|EC 2.1.1.98|Halobellus limi|TrEMBL
MLTFIGLGLYDERSITVEGRDALADADRAFAEFYTSHLVGATVEDLSDAHGIDVEVRDRA
GVEQHPEEILDAAEDEDVAFLTAGDTMISTTHVDLRLRAIERGIETRVVHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVVDSIEANRERGLHTVVYLDIKADRGEYMTA
DVAAEMLAEDWQDVLGVAVARAGSPDPTVAADRLSALAERDFGDPLHLLVVPGDLHHLES
DALATLGGAPADALAENER
>A0A7C4HG88|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELIFIGLGLWGIDDITLKGLNAARSADEVYFEAYTSVMGGLTKDNLEALIGKNVRALT
RKDVEENVEEILSRARDKRVAILVPGDPMVATTHVALRLEAEKLGVKTRVIHGVSIYSAA
PSICGLENYKFGRSVTIPFPEENYFPETPYLVVRENIERGLHTLVFLDVRAEEKRFMTVN
EGVAILLELEHKLSSQSPLLEKTLMVGVARAGSENPTVKADYPRNLLYYDFGSPPHILIV
TGSLHFKEIEALRLLAAAPLPPL
>A0A662NDI8|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MPIYFIGLGLYDEKDITLKGLEIARKCDVVFAEFYTSLLAGTTIEKIEQQIGKSIKLLSR
EDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSIYSAI
SITGLQVYKFGKSASVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYMTANE
AMNILLQVEEMKKEGIFTEDTLVVILARAGSLAPTLKAGYVREMIKGDFGKQPHILIVPG
KLHIVEAEYLVEFANAPKEILKEV
>A0A4D6GTC9|diphthine synthase|EC 2.1.1.98|Halobacterium salinarum (strain ATCC 33171 / DSM 3754 / JCM 8978 / NBRC 102687 / NCIMB 764 / 91-R6)|TrEMBL
MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRA
GVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAG
LTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHLRVDGD
AYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGS
LHHVERDALRELAGAPADAL
>A0A0F8UTH7|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>L0JZK7|diphthine synthase|EC 2.1.1.98|Natronococcus occultus SP4|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRAYAEFYTSKLLGTTVEELEDAHDVSIEVRDRA
GVEQEPDDVLTAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGITAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTKTIDANRADGLHTVVYLDIKAERDEYMSA
DVGAELLAEVYPDLVGVVVARAGSPDPLVAAGTMSELAERSFGDPLHLLVVPGECHLLEA
DALVELADADRDVLDIV
>A0A1C8ZW61|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. A20|TrEMBL
MGVLNLVGLGLAKKFITKSAVDALLNSDFIFFDRYTSKSCDINTDSLKEILNGKDVIEAN
RDLLENNSKIMLNYLDNNYKVSIATIGDALIATTHVSLALDARKRGHIVNVIPAVSVHCY
IVSKSFLSSYKFGKSVTVTFPYDNFIDYGPYHVIRDNKERGLHTIIYLDLKDGKAMTAND
ALNILLSMEDKHRMNVISKSNIVIVGARLGCENEKVIAMTVEEALNYDFGDTPHIIIIPG
TLHYMEADAIKWMLMT
>A0A7C0VPH5|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGIGLYDEKDITLKGLDAISCADRVFAEFYTSKMMGTTIDRMESQYQTKITVLSRE
AIEIDPSWLHHAKCENVVLLTGGDPLISTTHIDLRLRASDLGIATAVVHSASIVSAAPGL
AGLQNYRFGKSATIPFPYHTRSKTVVSETPYNVIIQNLANNLHTMLFLDIDRDRGCMTIP
EAVELLMRVDCEREHGTPMHSALGIGIARAGSPDVLIRCDRLCDLATFDFGAPMHLLIVP
ASLHPLEADALVRFADAPEWIR
>A0A662PTV7|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MAIHLIGLGLGTIEYLTLGALEVAERMDELLLDTYTSWIHPDLMDYLEERFGEKLVKADR
RMLEEEIEELVERAEEKEIGILVPGDPLIATTHISIVLEARRRGVPAYLTYGVSIISASA
SASGLQAYKFGKITTIPRDGVGIKTCYRVVAENLEKGLHSLILLDTADGGLRIPDALKML
MKVED
>A0A6A9T0E7|diphthine synthase|EC 2.1.1.98|Halapricum sp. CBA1109|TrEMBL
MLTFVGLGLYDERSITVAGREAIADADRVFAEFYTSKLAGARLDDVEAAHDTTIEVRSRE
GVERDPDPILDAAADGDAVFCTAGDTMISTTHVDLRLRAHDRGIETRVIHGTTAEAAASS
LTGLQNYRFGKATTLPFESSHGGEGVPDSVVETIEDNRQRGLHTLVFLDIKVEADREEYM
SGDAAAGLLAEHWNDEALGVVVARAGSPEPVVTADTLDSLAAQSFGEPLHMLLIPGDLHY
VERDALVELGGAPKAAVEELLV
>A0A830GFD5|diphthine synthase|EC 2.1.1.98|Halarchaeum nitratireducens|TrEMBL
MLTFVGLGLYDESSITVEGREAIADADAGAVFAEFYTSHLVGADVADIEAYHGVEIDVRD
RAGVEQRPEPILDAAESGDAVFLTAGDTMISTTHVDLRLRAHERGVETRVVHAPTAESAA
SSLTGLQNYRFGKATTLPFEWAHGADVVPGSVIETIEDNRSRGLHTLCYLDIKVGRGPEG
PDPDFEAYMSADYAADLLAEAWDSDALGVVVARAGSPDPVVRADRLSALADADFGGPLHM
LIVPGDLHHVEADALRGLAGAPDDLTTPE
>A0A3R7TY65|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED85|TrEMBL
MDSNGLFLIGMGPGGVSNMTEGAISAAKAADHRRYEAYTALWSEEDLSELEDRIGPIEKI
MRPEVEKPAQLLELASTSSVALLVVGDPLQATTHVDLQLQAAEAGVSCSVIHGISITSIV
SGAVGLSNYKFGRQTTLTYSYEGGWIATSPLEVIGLNHAQGLHTLAFLDLDPTGAGTGDQ
RPMQPKDAVESLLSMAEKLLLYSEEMPTDTVYDRMKFDSVVKICNEISSLMVILCSDMGT
KKQAIRYLSVSELSGATEGGLHCLVIPSELSEVEVTALQRWTKK
>A0A139CTS6|diphthine synthase|EC 2.1.1.98|Methanohalophilus sp. T328-1|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNAGKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEINIAFLTGGDTMVSTTHVDIRLRAMEMGIETCLIHGASIVSAICGL
TGLQNYRFGKAATIPYPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMDKGYMTV
NQGIELLLQVDEKRGENLIKGSIAVGIANAGSEKPIVRADFAENLESCDFGSPLHIVVIP
ADLHFVEAESLIKLADAPESILEEGDIN
>A0A075H6C7|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_42_E08|TrEMBL
MLSFVGLGISGFESIPIEGLETISNADIVYLEQFTSPISESDLKKIQDSIKGEFKLAKRW
LVEDGNEILEMSKEKNVVLLAYGDPYIATTHIELRARAIENKIKTHSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNLIEGNHTVLLLEYNQDKKFFLDPKDALKG
LLETEQGQARKVITESNYVIIASRIGFKDQAIVSGKISSLKETDFGQPPHTIIIPGRLHF
TESDALKLFGKCVDEPFDNSEKTEKISKQMIKKYVPMVREALEEIEPLYKNQKEFEVILD
NAERYIKDAEIFLGEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A6B1FIH8|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0675_bin_21|TrEMBL
MLHIVGLGVSDDSIPYNIEDIIQKADIVYLEVFTSPDINTSQIRRICPTLQMAPRWLVED
GRRILEESEYKDVVLASYGDPLVATTHTELRVRAAQRGIPVNVVHGPSAITTLVGECGLH
HYMMGRMATIMSEDTLLETPYMVSYRNAVLGNHTLLLLEYNQDADFFLKADVALQRLSDA
EKSYRRGVFTPDRHCIVACRIGTKRQLVVSGSLSSLEGYDFGEPPHSIILTGRLHFTECD
AIRVLTRCMDGPPENQTIKSIPQQMIEKYTPMIHKSIQDLPDCSNNEKLIVQNAISYIQD
AQRALESGQDEVAILSIGYADGLVDALRISHGMDPKI
>A0A7J2Z0H6|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLVLIGLGLSDEKDLSLRVIEEAKNSDKAYIELYTTAWFGDIKNLEEMIGKKIEVLKRKD
LEENSERILNEAKEKNLIIFVGGDPLVATTHSALLLEARKKGIKTKVIHNSSIISAIAET
GLHLYKFGPCVTIPFPEKTKGKLPESVYEVIKMNKSRGLHTLCLLDIAEESKLMSVKEAV
EILLRLEEERREDVINEKEKIVVFSKAGSEDSKIFFDTIKNLKEKEVALPAVIIIPGLLH
FTEKEFLEAISSFLPC
>A0A7J2ZLG2|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLTLIGLGLYDEKDLSLRGIDAAKNADEVFIELYTSKWHGNLKNLEKIVGKEIKILQRKD
LEENSAQIVDRAKVKDIAIFVPGDPLIATVHSSLLQQAKKNGVKTKVIHNSSIISAICET
GLHIYRFGSCVTIPFPDRTKGKLPESIYEIIKINRSHGLHTLCLLDILEQRAMDVKEAIE
ILLNLEDQRKEGIFKKDTEIVVFAKAGSENPIIDYAKVEDILKKKYEIPAVIIIPGILHF
TEKEFLSKI
>A0A497STX5|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
IVAEKNKLMKINEGLKILLEIEAKRKEGVISLEDEIVVFAKAGSEKPLLAFGKVKDILER
NFEDVPAVIIIPGLLHFTEKEFLKNFRICI
>A0A836BME0|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLWFVGLGISGVDSISVSTQKLLKQADIVYMEQFTSPISKSDTAKIKKLAKSKLKIAKRW
MVEDGTEILKNAKKKKVVLLAYGDPYIATTHIELRVRAIQEKIKTQTVHAASSLTSLVGE
AGLHYYKIGKIVTIMSELKSMTTPYYVIYKNLIEGNHTLLLLEYNQDAEFFLEPKNALNA
LLETEKEQKRKVIHPSTFVIVASRIGFKNQEITSGKISTLKKIDFGKPPHTIIIPGKLHF
TESDAIKVLTKCHDDPFDNSKTIKKIPKQMIEKYVPMVRQALREITPYFKDSKEFQEVLE
NAELYIQDAEKFLEQGKDEVAILSIGYADGLVDSLRIAKGLEPKM
>A0A3N5RF05|diphthine synthase|EC 2.1.1.98|Nitrosopumilales archaeon|TrEMBL
MLYLVGAGIYDTFEMCNSIDILKKCDRIYIEKFTSPISDNFIQNLKSTLEPGKKIEFVKR
WLVEDGRQILDESKTLNIGLVSYGDPTIATTFTELRIRAVRNNINVKVIHAASGITSLVG
ESGLQIYKIGKLVTMMEERQSALSVYTTIFNNLNLNCHTIILTEYRQNEDESVFFMKPND
VISRLLEVEKDIKYEFVSENSFLIVLSRIGTDRQRIVSGKIKSLLGIDYGEGPHAIIFPS
KLHFTEEDAILNLTEIIDRPDDNTAKIKCISDHMLNKYEPMIRNEIKQLRESLVSRKNEK
IQLELLENAELYLDDAIRFFRQGKKELAVLSIGYVDGLVDSIKQILRIE
>U1MME6|diphthine synthase|EC 2.1.1.98|Haloquadratum walsbyi J07HQW1|TrEMBL
MLTFIGLGLYDERSISIAGRDALQAADYVAAEFYTSYLVDATVSDLETAHDIDIDVRDRE
GVEQHPEDILRKAQSEDVAFLTAGDTMISTTHTDLRLRAIDRGIDTRVIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPYAHGAEGVPTSVTDSITANRERGLHTVVYLDIKADRDEYLRA
SDAAEMLATDFEDMLAVVVARAGSPDPTVRADRLSALAEKDFGDPLHLLVLPGELHHLEE
EALAALADAPADMLNAVDSQ
>A0A7J3EMR7|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MNVGGELILVGAGLSTDLITLRGIRRISEADVVYVDSYTSVTLGDLRGFIRSQTGKEVLL
LKREDIEERYFEVLIRPALEGRKVVLIVPGNPLDATTHVALLSEASRRGVEFEVVPAPGI
IPNALTMSGLMIYKMGKIVTLTYPKSGILSEYPYDVIKDNDLRNLHTPLLTEIDLEKGIK
MQVREAVEILLLLESRRGEGIISETRKAIAVSGLGWDKQRICFGALKDLAKLADHEGPHT
LIITSPKMHFLEEEVAQIISRRYCHEIK
>A0A832S547|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MKFVLAGAGLRCEHLNERVKRAILEAEEVWVDTYTSPFPGGLLNCVKGVREDALEADRSV
LEGPFRFSKSVTLVVPGDPMAATAHSALLLEARRRGYSVQIISNVSALQAARSKSGLSQY
RFGKVVTLMYPKEGISFTESVYNVIKDNDSMNLHTIVLLETGYGRDMTVPEAARLLCEYE
ELCDRRAIAMARLCWDDETIKVAKLRELAESDLGGPPHLLVFPSPKLHPIEEEFIEAVLK
>A0A075MR07|diphthine synthase|EC 2.1.1.98|Candidatus Nitrososphaera evergladensis SR1|TrEMBL
MLWLVGAGISGHRGLSLEAVQVLKKCDIVFVERFTSALSDSDLEGINAAIGKSAKPVQRW
FVEDGREMLDAAKEKQVALVAYGDPLLATTHTELRARAAKASIETGVLHAASGITAIMGE
CGLHMYKFGRTVTMMSEPKSAVSVYNTVFDNLLLGSHTLILTEYSHDEKTGEPFFLDPTA
VLKMLLDCERDLRHHVFSEETFVVVASRLGSSDSRIVSGRIKSLAGVGFGAGPHSVIVPA
GLHFTEEEALEALTVCLDSPADNAASVKRISSQMIERYAPKAKEAVRHMRDILRKEGAKE
KENNKGMHEVLDNAEYYIDDAERFLRQGKHELAVLSIGYAEGLLDALRFQKGINPWNP
>V4HGQ3|diphthine synthase|EC 2.1.1.98|Candidatus Halobonum tyrrellensis G22|TrEMBL
MLTFIGLGLYDERSVTVEGRDALRAADRVFAEFYTSRLVGASVAELESHHGVDIEVRDRA
GVERDPETILEAAETDEVAFLTAGDTMISTTHVDLRVRAAERGVDTRVVHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGADGVPASVVDGVEANRERGLHTLVYLDIKVAGSSPAGP
QAGEDDEFMTADEAAGMLADDWDPDALGVVVARAGSPDPVVAADALSALADREFGGPLHT
LVVPGDLHHLEAEALERLAGCPAALLPDE
>B5I9W5|diphthine synthase|EC 2.1.1.98|Aciduliprofundum boonei (strain DSM 19572 / T469)|TrEMBL
MLTFVGLGLYNTEDLTIRGKREIEEADIVFGEFYTSRLIGVNPEDLGEALGREIKILSRE
EVENGKLILKEAKSKNVVLIVAGDPMIATTHVALRVMAEERGIKTKIVHNSSIVTAAPGM
LGLQQYKFGRTVSLPFPQENYFPTSAYDFIKINQNLGLHTLILLDINPRPMTANEAMKIL
LEMEEKKREKIFSKNTLIAVVARAGAPNSLARAGYLGDMINGDFGSPLHTLVLPGKLHFA
EAEALVKLAGAPEEILDK
>A0A2R6ME33|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_8_65_20|TrEMBL
MLTFVGLGLWDEESITVEGRRALRGADDVFAEFYTSRLMGTDPESLAAHHGVEIDVRDRA
GTEQEPGPVLDAASDGDAVFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGTTAAAAAAS
LTGLQNYRFGKATTLPFPYAHGGDEVPASVCETLDANREHGLHTLVYLDIKREREEYMTG
DVAASLLAEGYEDVLGVVVCRAGSPKPRVEAGRLSDLAGRKFGGPLQLLVIPGELHYIES
DALRALADAPESLTEPV
>G4RMD9|diphthine synthase|EC 2.1.1.98|Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)|TrEMBL
MARLYVVGLGISPAFLTEAAKEALERSDCVFADSYTSYYDFSKLGARVTLLDRRELEDRS
GAAIEECLRRGKDAALLVPGDPLTATAHAALIAEFRRKGHEVVVIPGVSIVCAALSASCL
SVYKLGGVATVTYPRLGVYSLRPYEVVEQNLQRGLHTLLLLDIRDDGGFMTPSDAANILM
ELEARERRGVFSGDRRVITVYRLGWPEGGVAAAPLAELASSAYPAPAVIIVPARLSPVER
ECLVSLYGAPLDI
>A0A832ZW51|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
MTLLFVGMGLGPLRYLTKAAEEYLRSSEVVYVDTYTSKVERELMSYIREIVKGRLIAADR
DLLENRMKEIVEEARVKNVCIAVPGDPFIATTHVALREEARKLKVGEEIVFGVSAYTSAI
SLSGLHVYKFGKSASIPLTDDINQVRQSYYTLLENQSRGLHTLFFLDTKDGGLRAGKALE
LLLKVENEEGRGVVRSGTLVIVVARIGYDDATITAGRLENLINHTLPPPPHMLIFPGELH
FTEKEVIKFYALNADDVERHAPVNYIRDRVLKYVEKTRRVLQEVRGQDVGEEFCNYVEAY
VDDSKNFLTSGDYVNSLLAIGYAEGLLDALRLLGVVRFEW
>E6NBJ0|diphthine synthase|EC 2.1.1.98|Caldiarchaeum subterraneum|TrEMBL
MVLTFVGGGLGRFEHLTIEALETVKNAEKIYVDTYTSFWAADFFDKLREAAGHVVAADRK
MLEDNVHKLVSEAVENEIVLLTPGDPFIATTHLAIRTLAHRKNVSVKVVHGVSAVSAAVS
SSGLHIYKFGKTATIPKTTDSNMLNEIFKTIETNLSNNLHTLLLLDTSDHGLTIPEAVKQ
LLDYSKQHGKSFINQNTLMMALARLGFPDNMTLAAPAEKLMIHNFPPPPHSIIIPSNLHF
TEEEILQTFHKGPLCIAENPLKSRVMNYVVKCRIILADLSDFHELTDYLGYVSRYVEDAE
RFVKDGNMVDALLAIGYAEGLLDALRLRGEVTFTW
>A0A2K3JJM7|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon M9B2D|TrEMBL
MKKNSKAHLVFIGLGLYDEADISLKGLQELKKCDKVFAEFYTTILGTFDRESFEERIGKK
IDVLSREETEKADKIIDAASQNHVAFLTGGDPMIATTHVDLRLRAMKQGIPTTIIHSGSI
VTAVPGLLGLQNYKFGRTTTLAFPEKTYFPTSPYTVIYNNRNLGLHTLVLLDIQAEKNHY
MTANQGFEVLLTMEEKLKKNLLTPDTLACVVARAGAENPMVVANTIGKLQKKTYGPPLHT
IVIPGDLHFMEIEALELCAGLPSEIKRKIQKL
>A0A257MR75|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. ASM2|TrEMBL
MLTFIGLGLYDEKDISIKGREAIAAADRVYAEFYTSRLMGASLSRLEEFHGRKIHLLSRS
QVEVEPSWLEQARDEDVVFLVGGDAMVSTTHLDLRLRAMLMGIKTRLIHSSSIVTAVSGL
SGLQNYRFGRSTTIPFPYLARGKRIVPETPYRVLQENLARNLHTMLFLDIQRDPVERYMT
AGQGAALLLEMESEAEDKLPPGTLGIGIARAGSDDAVIRADRLSRLKDCDLGGPLHILVV
PARLHFMEAEALRVLAAAPEDALMGAD
>A0A832WFS6|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLSFVGLGISGFESIPVEGLEIISNADIVYLEQFTSPIGKSDVDKIQNAIKGEFIHAKRW
LVEDGKEILEKSKEKNVVLLAYGDPYIATTHIELRTRAIELKIETRSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQNKDFFLDPKDALKG
LLETEEGQGRKVLTESSYAIVASRIGFKDQAIVSGKISSLVKIDFGKPPHTVIITGRLHF
TESDALKLFGQCIDEPFDNSEKTEKISKQMMKKYVPMVREALEEIIPLYKNQKEFEVILE
NAELYIEQAEIFLDEGQDENAILSIGYADGLVDALRLAKGLEFKM
>A0A7J4RQJ1|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MLWFVGLGIAGADGIGSDAIKIIKKADLVYFENFTSPITKSELVKIKKIVKGEFKTAPRW
LVEDGKAILREAKKKEVVLLSYGDPYIATTHIELRTRAILEKIRTKTIHAASAITSLIGE
CGFHFYKVGKIVTMMKDQQSVSSVYYTLYDNLVAGNHTIIILEFNSDAKFFLNPKDALSS
LLVAESGQKRNVIDYSSFVIVASRIGAKNQKIIAGKISSLVNTDFGKPPHTIIIPGRMHF
TESDALKVLAKCIDAPFDNSSKIQKISEQMLQKYIPKARKALEEVINRFKDDKSLQSVLE
NAELYLDDAEKFQNQGKEELAVLSIGYAEGLIDALRFSKGIDPWT
>A0A4U7E698|diphthine synthase|EC 2.1.1.98|Halorubrum sp. GN12_10-3_MGM|TrEMBL
MLTFIGLGLCDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A075I5M7|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_14_E04|TrEMBL
MLWFVGLGVSGPDSIPKEVGKIIQKADLVYLESFTSPIYKEHEEDIKNLVNGNFKIAKRW
LVEDGQEILKAAKIPL
>A0A075I5Z8|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_14_E04|TrEMBL
MILLSYGDPYIATTHIELRTRAKLENIETKTAHSASVITSMIGEVGLQFYKVGRIVTIMS
EKNL
>M0LZG8|diphthine synthase|EC 2.1.1.98|Halococcus hamelinensis 100A6|TrEMBL
MLTFVGLGLYDERSITIEGRDAVRGADRAFVERYTSTLGGASVADLEAYHDVEIEARDRA
GVERDPAAVLDAAETEDVAFLVVGDPMVSTTHVDLRLRAHDRGIDTRIVHGTTAQTAASS
LTGLQNYRFGKATTVPFAYGDRPVPGSVVDTIEENRDRGLHTLCYLDIKAAEDRYLTANA
AADRLAPALDDAIGVVVARAGSPEPCVAADTLDQLAEREFGDPLHLLVVPGALHDLEREA
LSALANAPDRLFADGS
>A5ULC8|diphthine synthase|EC 2.1.1.98|Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)|TrEMBL
MFLKSYTMFYLVGLGLFDAGDISLKGLKCLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A075G7S0|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_110_B01|TrEMBL
MLWFVGLGISGTRSIPIEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILKTSKSSTVVLLSYGDPYVATTHIELRTRAKLENIETNTIHSASAITSMTGE
AGLQFYKVGRMVTIMNEKKSTITPYTAIFKNLTQGLHSIILLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVLNNDTFAIIASRIGFETQKIISGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSTRIKSTSVQMIEKYVPMVRKALEEIRPLYNDTKEFQEVFE
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRIAKGIDPKM
>A0A211YMH5|diphthine synthase|EC 2.1.1.98|Pyrodictium delaneyi|TrEMBL
MALYIVGAGVSSEYLTLKAIQVIGAADKVYLDTYTSIAPGVDRELVRRLNPRAEVVEAPR
RLLEDEAGKLIQEAREKTVVLLVPGDPLHATTHVALFIEARRRGVEAHVVPGVSGLQAVI
DATGLQVYRFGKTVTLVYPEEGFKPYSTVETIWANRERGLHTLVLLDLRLDAGHAMTIPE
AIRILLELEAELAAEEGREPEIRGAVVVGVARAGTSEQRCIAGTVEEVAAASYPPPPHSL
VVAAPRLHPVEEEALEVLCGCKTCREKGKA
>A0A6A9QL95|diphthine synthase|EC 2.1.1.98|Sulfuracidifex metallicus DSM 6482 = JCM 9184|TrEMBL
MGELYFIGMGLSRSLMTEGAKHILANSDIIIYDTYTSVSCDITPDYIKSITRGEVIEADR
NLLENRSNEIIAMAKEKIVSIATIGDPMIATTHVSLAIEARKSGIKVNVIPGISVHCYLI
SKSMLSSYKFGKSVTLVYPSYGILDTAPYYVLKSNKAQGLHTLIYLDIRDGKFMSPKDAV
SLLLKMEEMKNEGVINENDLIIVGSRLGCPDESIMCIQVKDVADHNFGNPPHILIFPSNL
HYMEADALKWMTQK
>A0A5J5FFR5|diphthine synthase|EC 2.1.1.98|Thermoplasma sp|TrEMBL
MLNIIGVGLRGTGSITFDEFDALRTSDLVYIDQYTSIGQPGLVRKISAMIDRDIVPLTRE
EIENGSILPEAETKTVSLIVVGDPLMATTHNEIRYEAMSRGIPVRIFENASILNAAIGKA
GIMVYKTAPPVSLPKVSDKFFPVSVIEKIKRNMDMGLHTPVLIDLEDQENIPLHDALNSL
LQMEKKKGYDGIIDEICVLSRISFPDERIIFGKIADLLREDVRSPYMLIVLSKLDDNERR
FITSFSERTIRG
>A0A831PAE8|diphthine synthase|EC 2.1.1.98|Methanoculleus sp|TrEMBL
MLSFIGLGLFDGEDISLKGLKKIQAADHVFLEGYTSRLMGIKICEMENLYGKTVTVLGRE
DVEQHPDTILEYARDSNVAFLTGGDPMVSTTHADLRIRAAERSIPTEIVHGSSISSAVCG
LSGLQNYRFGKSCSVPFPSKGWFPTAPLETILTNQSLNLHTLVYLDIQQERYMTVPQAIE
LIEEMAEKEHKDAPRIFVGIARAGSDTPHVAAGDAETLKEHDFGDPLHVLVIPAHLHPIE
EEYLTTFAGL
>A0A0B3ARF8|diphthine synthase|EC 2.1.1.98|Archaeon GW2011_AR11|TrEMBL
MTLYFIGLGLSDEKDISVKGLEAVERCGAVYLEHYTSVLNCAKQDLEKFYGKRVILATRA
LVEQDAEATILKDAAEKDTAFLVIGDPFCATTHVDLYLRARKAGIACRIIHNASVISAVG
VTGLQVYKFGKTTSIPFSNEQVDSPYEAMKENRKMGMHTLFLLDLDPIEGRYMTVGDAIR
YLLRAALRKGDGGFKDSTLCVGCARLGAKDPIIKAGSASQLLKADFGKPVHCLIVPGQLH
FVEEEALTLWKKENIQ
>A0A133VAN0|diphthine synthase|EC 2.1.1.98|candidate division MSBL1 archaeon SCGC-AAA261F19|TrEMBL
MLTFVGLGLQKNGLTLQGLKEARGADTVFIELYTSLVPGLTLNELEEKISNQIIVLNREA
VEEHPDEILTAARDGKAVFLVPGDPMVATTHVDLRLRAEKIGIGTKIIHGPSIESAAPGL
SGLQSYKFGRSATIPFPKTPSETPYIVVKQNKKLGLHTLLLLDIEASKKRYLTADEAIKI
MLKLEEKLRADAFTPESLVVVVARAGTSDAEVKGGKAIDLSKLNFGSPPHVLIVPSKLHF
FEAEALKILGNAPAEVVEKYVEK
>A0A2R4X3B3|diphthine synthase|EC 2.1.1.98|Halococcoides cellulosivorans|TrEMBL
MLTFVGLGLYDERSVTQRGADAIASSDRAFVETYTSRLMGATIADLDAAHDRSFEPCDRD
RVERNPDPILDAAADGDAVFCVVGDPMIATTHVDLRLRAIDRDIETRVIHGTTAQTAASS
LTGLQNYRFGPATTIPFPETHDGLPDSVTDRIAENRARDCHTLAFLDIDRANDRYLRADR
AAGLLAEADDGLGVVVARAGSPEPLVDADRLSALADRSFGDPLHMLVVPAALHPLERDAL
EALGDAPADLLESE
>A0A662NU96|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MAIYFIGLGLYDERDITLKGLEIAKKCDLLFAEFYTSLLAGTTIEKIQEQVGKPIKRLNR
EDVELNFERIVLKEAKDKDVAFLTAGDPMVATTHSDLRIRAKQMGIESYVVHAPSIYSAI
AITGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENKERGLHTMLFLDIKADQGRYMTANE
AMEILLQVEEMKGERAFTEDTLVVVLARAGSLNPTLKAGYVKDMVKEDFGRQPHVMVVPG
RLHIVEAEYLVEFAGAPKEILDEA
>A0A165N1Q3|diphthine synthase|EC 2.1.1.98|Haloarcula sp. K1|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDVLETSIEVRDRA
GIEQDPEPILEAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGLETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRERDLHTLVYLDIKVDDPHWDES
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVAADTLDALAAQSFGEPLHLLVIPG
SLHPLEADALESIAGAELE
>A0A2R6JUM8|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_8_69_26|TrEMBL
MLAFVGLGLYDERSITVEGREVLAEADRVFAEFYTSKLVGTTVADLEDYHGIEIELRDRA
GVEQRPGPVLDAAGSGTVAFLTAGDPMVSTTHVDLRLRAHGRGIDTRVVHGTSAATAAAG
LTGLQNYRFGKATTLPFPDVHGGVPDSVLDTLSDNADRGLHTLVYLDIRADEDEYMTAAT
AAGLLADARGDGLGVAVARAGSPGPVVAADRCSALADREFGDPLHLLVIPGDLHHLEAEA
LRELAGAPTDLVDVD
>L9YR54|diphthine synthase|EC 2.1.1.98|Natrinema pallidum DSM 3751|TrEMBL
MLTFIGLGLYDERSITVEGREALQAADRVYAEFYTSKLIGTTIDDLESHHDIEIEVRDRA
GVEQHPDDMLEAAEGEDIAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIDDNRADGLHTVVYLDIKTEREEYMTA
DTGATLLAEEYPDLVGVVVARAGSPDPLVEAGTMSELAAREFGEPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A075HY28|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote KM3_86_G05|TrEMBL
MLWFVGLGISGTRSIPVEVVKIIQEADFVYLEAFTSPISKQHEDEIKNMVNGSFKIAKRW
LVEDGQEILRTSKNSTVVLLSYGDPYVATTHIELRTRAKLENIETNTIHSASAITSMIGE
AGLQFYKVGRMVTIMNEKKSTITPYTTIFKNLTQGLHSVTLLEYNHDENYFLDPKDAISN
LLDVEKEQKRNVLNNDTFAIIASRIGFETQKIISGKFSNLLKVDFGEPPHSIIITGKLHF
TESDAINVLTECLDKPSDNSTRIKSTSVQMIERYVPMVRKALEEIRPLYNDSKEFQEVFE
NAELYINDAENFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>F6BE01|diphthine synthase|EC 2.1.1.98|Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)|TrEMBL
MLILAGLGLYDEKDMPLKTLEFAKKVDKIYAEFYTAVLTGTTIEKIEETLGRKIEVLSRE
KVEYETEKLIEEAKEKDIMFLTAGDPMVATTHVDLAVEAKKRGIDVIIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKENLKMGYHTLCLLDIHADKNKFMTANEGL
KILLELEKRRKENVITENTKVVVVARAGSLKPKLVYGKIKDLINYDFGKPLHCIIIPGKL
HFMEEEALKYLCENV
>A0A6G1WZB6|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLVFIGLGLHGEGISLQGLREAQRADVLYAEIYTSLVPSFNLKKLEREIGKLIQVVGREA
VEQHPDEILETAKIRKVAFLVPGDPMVATTHVDLRLRAAKAGIETKVVHAASIASAAAGL
AGLQSYKFGRTATVPFPDNPSQVPYETLVENRKRGLHTLLLLDIRAKEGRAMLAGEAIEI
MIGLEEKLRKNAFTPDTLAVVVARAGSDDAVVKADRVGKLRELDFGPPPHVLIVPGKLHF
VEAEALRVFAGAPEAVAK
>A0A7C3Y7P4|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
LVPGDPMVATTHVDLRLRAARMGIETRVVHAASIFSAAPGITGLQSYRFGPSATVPFPDN
PSARPYEVLAENLRAGLHTLLLLDVRAEEGRAMTIREAVEIMLGLEGRLRMGAFTGDRLA
VGIARAGWEDCVVKADRAVKLMKFDFGGPPHVLVVPGKLHFMEAEALRAFAGAPEELIR
>A0A497LLH4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MFVGLGLYDEKGISLKGLEETKNADAVFVELYTSLMPNLSVKNLEKIVNKKLHVVSRKQL
EEENGKIILDVAEKGKAVLLVPGDPLVATTHIALRIEAEKRGIRTRVVHGASIISAVIGL
SGLHNYKFGKTVTIPFPSETPPETCYNVIAQNKGLGLHTLCLLDIKAEEKRFLSIREGLE
ALLKMEEQRRERIVTMETLAVGIARAGSDNPAVKADYVKELLNYDFGKPPYSIVFPGELH
FMEVEALIVLADAPEELRKFVK
>A0A7C4WUW1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKTGELIFVGFGLGEDGLTLKGLEVIRNADEVFVETYTNYTPERVLKRLENTSGRTFRRI
SREDLEDLGGKLILDKAVKSRVVLLTPGDPFTATTHIALRLEAEKRNIKTSVINSSSVVT
SAAGACGLQTYKFGETATVCFPDEEVISTKPYETTFYNLARGLHTLLLLDYRARENRTMT
INEGLEILRRIENLKQMGVFTEDRLVVGLARLGYDDSKVKGGRLDEIIYEDFGEPPHCII
VPGTLHFLEIEALMRLAGVKKSHVESIPRFRGFIELDVLDRYINGVKNVFREMKILGESR
EMSNRELNLALEWARNYYDDSIAFKLKGDLVSSLIAIAYCEGILEGLRLLKFVDFKWEGE
R
>A0A7C4NGP9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRTGELTFVGFGLGEDGLTLRGLEVVKSADEVYIETYTNYTPEEVVKKLENISGRNFRRV
SREDLENLSGKSILDRAIKSKVVLLTPGDPFAATTHIALRLEAEKRGIKTRVVGSSSIIT
SAAGAIGLQIYKFGETATICFPNGGAISTKPYETTFYNLARGLHTLLLLDYRAFENRAMT
VNEGLKLLREIEEEKQMGVFTEDRLVIGLARLGYENYKVKGGKLGELIREEFGEPPHCII
VPGALHFLEAESLMYLAGVSRSLVESIPRFRGFVEVDILDKYIFGVKNVFREMKILGETR
EMLSEKLNLALEWARNYYNDSIAFRCKGDLVSSLVAIAYCEGILEGLRLLKLVDFKW
>A0A537FPN7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDRVAFLVPGDPMIATTHISLRLSLSKTGIGSRIIHGPSIISA
VCGATGLQSYKFSKTVTIPYDPPLPASVLETISDNHGRGLHTLLLLDVKADQNKQLTIAE
ALTKITSANPSLESRLAVGVARIGARDERVKASRIGLLINEDFGGPPQSIVVVGKLHFME
ADALRIICGAQDSDLRENY
>A0A7C4GNZ9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVFVGLGLYSHADISLRGLEEVKRADYVFAEFYTSVMPGFNIDEFRRVSGKDPIIVSRRN
IEDEDGILILEKARRGRVIFLVPGDPLIATTHIALRVKAERMGIKTRVIHGASILSAAIG
LSGLQNYRFGKSVTIPFPERDVLSRTPYIVIAENKRRDLHTLCFLDIRVEELRYMTINEA
LKILLTLEENIRQNVVGEESLAVGIARAGSENPIVKAGAIKDLLNFKFGDPPHTLIVPSE
RLHFMEAEALITLAGAPEWVRGMVK
>A0A523ZR69|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFIGLGLCDEKDISLRGVEEIKEADAVFAELYTSLMPGLSVQKLEKLVGKMVSIVS
RRVLEEEEGGLILQQAKKGKTVLLVPGDPLIATTHVDLRIRAEGQGIKTRIIHGASIISA
VIGLSGLQNYKYGRSVTIPFPENGFISETPYRVIGGNRKMGLHTLCFLDIRADEKRYMTV
KDGLETLLTMEKRKRNQIITKETLVVGIARAGSKTPIVKAGYVENVLNYDFGAPPHILVF
PGKLHFMEAEALITLAGAPEEIRERVQ
>A0A7J2LQE4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLLLEGSYLGELAFIGMGPYDEKDISLRGMEELRVADKVFVELYTSHMAGLSIANLERLC
GKPVTVVSRREVEEEEGKRIIEASRDGRVAFLVPGEPMVATTHVALRIKAEKEGIKTRII
HSSSIISAAISLSGLQSYKFGRNVTIPFPEERVFSEVPYQVVAQNMSLGLHTLCLLDVLV
EKGRFMPVSEGSTYLLGLERIKKGAVLNEDTLAVGIARAGSPNPEVHADSIEKLRRWDFG
PPPHSIVIPGNLHFMEAEALITLAGAPEEVTNRLVQDRKHGE
>A0A7J2J5T9|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MRKMGGLYLVGIGLGEKGISVKGLEIARKSDMVLLDSYTNVIDENKVKTLSGLIGKEVRL
ADRTSLEENIDPLIEESKKKRICILVPGDPLLGTTHISIVVRARELGVKCEVIPGASIFS
SIGLTGLSPYKFGRTVTIPHLEKSFKPRSFYYQIKLNKDVGLHTLVLLDTERGGMSPSVA
VTILDEIENEERLGVVSNSDLIFVLSRIGEENQHICLDRLESVISKEFGPPPHSLVLPGK
IDEVEREMIKALFGVEV
>A0A7J2NID2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGKIVLIGLGLHDEKSITLEALECAKGCDMLFAEQYTSLLAEGSIERLERRIGKEIQLLD
RKRIEDGSFLILAREMAIGLLIPGDPMTATTHVDLRIRAHEKDIECEIVHGTSVIVAVPG
ILGLQHYKFGRTVTIPFNEAGYDPTSPLELLMKNLENGLHTLALLDIQADKERYMTANEG
LEWILRTAEKLGYDVIGENLLACVVARAGSKDCMARADKLSELIKMEFGPPLHTIVIPGK
LHFQETEALIRLAKAPPELFMKL
>A0A7J4CZQ4|diphthine synthase|EC 2.1.1.98|Marine Group III euryarchaeote|TrEMBL
MLTIIGLGLGGPNSITMDGVISLSLADHIFYETYTSPIHPETLEWVKLKSQKEPIHLSRG
QVEEPAELIDLAKEKNISFLIVGDALSATTHVSLLLECKKNNVEYQVIHNASVLTAVAGV
LGLQHYNFGPVATLVLPEGNYKPTSPIDKIKTNMKNGNHTLVLLDIKADQPETEPIYMTA
SQAAEQIMEAGLSGEIKVAAAARVGREDQRLWYGKLKELAKLDLGKEPHSLVVPSRLHFT
EKDFLDNL
>A0A7K4NT91|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote|TrEMBL
MLWFVGLGISGTKSIPIEVLKIIQEADFVYLEAFTSPISKQHEDKIRNMVNGSFKIAKRW
LVEDGQEILKASKNSTVVLLSYGDPYVATTHIELRTRAKSENIETSTIHSASVITSMIGE
AGLQFYKVGRVVTIMNDKKSTIAPYTAIFKNLIQGLHSIILLEYNHDEKYFLDPKNAISD
LLDIEKEQKRSILSDDTFAIIASRIGFETQKIIAGKFSNLLKIDFGEPPHSMIITGKLHF
TESDAINVLTECLDKPLDNSDKIKSISVQMIEKYVPMVRKALEEIRPLYNDSKEFQEVFE
NAKLYIDDAENFLKQGNDENAVLSIGYADGLVDALRIAKGIDPKM
>A0A833E1N6|diphthine synthase|EC 2.1.1.98|Thermococcus paralvinellae|TrEMBL
MAIYFIGLGLYDEKDITLKGFEIARKCDLIFAEFYTSLLAGTRVEKIEKLIGKPIRVLSR
EEVELHFEKIVLSEAKNKDVAFLTAGDPMVATTHADLRIRAKQMGIESYVIHAPSIYSAV
SITGLQIYKFGKSATVSYPEKNWFPTSHYDVIKENGERGLHTLLFLDIKADLGRYMTANE
AMEILLQVEGMKMQNVFTPETLVVVLARAGSLNPTLRAGYVRDMIDENFGKQPHIMVVPG
RLHIVEKEYLVTFADAPAEILKRRDL
>A0A4C2EJS1|diphthine synthase|EC 2.1.1.98|Haloarcula mannanilytica|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLVGTDLETLEDALETTIEIRDRA
GIEQDPEPILAAAESEDVVFCTAGDTMVSTTHTDLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASHAADLLSESFPDTLGVVVARAGSPDPLVVADTLDELATQSFGEPLHLLVIPG
SLHPLEADALESLAGADLE
>A0A1F9Z7C6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon RBG_16_67_27|TrEMBL
MGDLTFVGLGLQDEKGVTLLGLDVARAADVVFGEFYTSVLPGARLDALESLIGKRIRVLS
RPEVESGEVVIEAAKASRVVLLVGGDPMSATTHVDLRLRAHVAGIPTRIVHGVSILSAAA
GALGLQAYKFGRTTTVPFPAPNFRPSSPLETILANLRQGLHTLVLLDLREDGTFLDPKVA
LREVLEAGERLGTRDVTADTIACVLSCVGSDAPGLRAERIRRLLEMDLGPPLHCLVIPGP
LHFLEREALIAFAGAPHDIGGP
>A0A081S5F4|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote SCGC AAA799-E16|TrEMBL
DKDFFLDPKDALNGLLETEKGQRRKVISSSTFAIVASRIGFKDQEIVSGKISSLKKRDFG
KPPHTVIIPGRLHFTESDALKVLGECIDEPFDNATKTRKISAQMIEKYVPMVREALEEVE
PYYKDQKEYQVILENAELYVRDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A347AGX4|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. BRmetb2|TrEMBL
MLYFIGLGLFDEKDISLKGIEILKKVDTIYAEFYTAKLFGSTFSSLEEIVESPIKILSRK
EVEEDNIPINSALDNDVAFVTAGDPLIATTHSDMMIQAKKRGIDAQVVHASSILSAAPGI
AGLQAYKFGKVTTIPFPEKNYFPHSPYLTIETNMKFKAHSLVLLDIRAEEERYMTANQGL
DYLLNVEKERNKKIVLNDSIAVVIARAGSLKPLVRSDRIQNLLNEDFGGPLHSLIIPSQL
HIMEAEYLVEVAGAPEEILKKSI
>A0A7J4KJE9|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MENGKLYLVGLGISDEKGTSLQGLQKLKECWKIYAESYTNLLPEGTLARLEKLVGKPIEI
LSREQVEGEKEILQSASSAPTALVVSGDPMIATTHISLVLAAKKKGIQTEIIHASSILSA
AIGESGLQAYKFGKTTTLAYWRENYKPMAAYDTIAENLSRGLHTLLLLDIDEKLGPMPPS
EAARILLEMEKQGKKGMLTLETKVVLLQGVSYGGEQRKVFAPLLAFSQMSAMRPCVLILP
GALHFLEEEFLQSL
>A0A832YSW8|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDERDITLKTIEYAKRADKIYAEFYTATLTGTTLEKIEETIGKKITVLSRE
KVEYETDKLINESKDKDIMFLTVGDPMVATTHVDIAVEARKKGIELIIINAPSIYSAVGI
TGLQIYKFGKTTSIVFPEPKYFPETPYYVIKDNLNMGLHTLCLLDIQADKNKFMSANEGL
EILLKIETNKKENILKKDTKAIVLARAGSLNPKIVYGKIEDLIDYDFGPPLHCIIIPGKL
HFMEEEALKYICENI
>A0A662UV98|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MTLYFVGLGLSISHLTLKAIEVLRKVDKIYIDTYTNIVPDFDLDVLKSIIGSKKKFVFAS
RKDLEGVNISRIVDEARENDIAILVPGDPFIATTHDAIRVEALSRGVSVETVHGISIYSA
IASATGLQAYRFGKTVTLVRPSVSKPFSVIETIYANLKLNLHTLVLLDLKLEEGYAMTIN
EAVEILRELEKEYSDEQLLRGVIGIGVARLATRDQVIKADLLYNLKNYSYPPPPHSIVIV
AKPHPIELDLLKYIGDLPDNIYQILLKSKEYPL
>I3D495|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopumilus salaria BD31|TrEMBL
MLWFVGLGISGFKSIPSEALDVLSKADIVYLEQFTSPIGKSDLTKIKNATKGKFIPAKRW
LVEDGKEILENAKKKKVVLLAYGDPYIATTHIELRTRAIEEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMNEIKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALDR
LVETEKGQKRNVISSDTFAIVASRIGFKDQKIISGKISSLMKIDFGKPPHTVIIPGRLHF
TESDALKIFGQCVDEPYDNSEKTKKISIQMMKKYVPMVREALEEITPYYKDQKEFQGILE
NAELYVQDAEKFLEEGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A0Q0WLL1|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. SDB|TrEMBL
MLSFVGLGLYDEKDVSVRGLETIREADMVYAEFYTSRLMGSSHEQLREFYGKEVRLLSRE
EVEVSPDEWMSNALDKKVAFLVGGDPMISTTHLDLRLRALKMGITTRIVHSSSIVTAVSG
TTGLQNYRFGRSTSIPYPYLAGGKRIVAQSPYEVVVDNLERNLHTLLFLDIQTDRFMTAG
EGAALLLEMERSAGRDRLAFSLGVGVARAGSEDAKVLADWLPRLAECDLGGPLHILVVPA
KLHFMEAEGLVALAGAPKEIQETAEP
>A0A1F6R5V4|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon RBG_16_49_10|TrEMBL
MSFSLFGIGLSGDNSITFEEMENLKKSDKVYFEVYTSKWEGNISKIEELINKKILFVKRL
DLEENSKKILEEAKSKNIAILVLGDPLVATTHITLLLEAKKMGIKTKVIHNASIYSAVGE
TGLHLYKFGATVTIPFPEKTNNQSPLSTFETIKQNRKLGWHTLCLLDLIAEKDKYMSPNE
GIEILLKSKEINKEDDIVVFGRAGSEQPLIAFGKIKDLIKKDFGDPPFVLIVPGKLHFTE
KEYLEFYRVGG
>A0A5E4I4L2|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGIGICDETDMSLRALEVLKKCSIVFAESYTSILSEGTLSRLEKLCKKKIKLLKRA
DVENEKEILSACSDDASVCLLVAGDPLIATTHVSLLLAAQKKNIPTKVIHSSSILSAAIG
ESGLQAYRFGKIVTIPKWKPNYTPSSPYDTIQENLSRNLHTLLLLDLDEKGEHLEPKEAL
RELLSMEEEKKKGIILHTTNFVLLSRVGWPTQRRIYSSLAALLDGHTDDLPAILILPAKL
HFMEEEFLAEFAMESGL
>A0A7J2VYX4|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLMPLLLVGMGVHGAQGIPVGAVEELRRCDRVLLDSYTTPIDPVRVLKELRVLLGTEVKE
AGRDELEDVQGLLRSASAGCLGIVIPGDVFVATTHDAIRQEAARSGIEVRIWHSSSIVSS
ALSRVGLHIYKLGFIGTLVAGPPQTAYRAYFGVTGALRNSQHSILLMQHDPASGEGIDVG
DGLRALVEAESSWRLGSFGPDRIIVIASRLFSESESVRVLRLSDALDTDFGEHPHTIIVP
GRLHYTEAESMRAVLGVPQELTDAMGTVPRSLAARLAGTAIEKSRAALPKFRSSISGSPG
VNSVLENVESYLSDAERFLGEGNVELALAEAGYAEGLLDSLRLLGYAGIEW
>A0A151EK32|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon SG8-5|TrEMBL
MGKLIFIGLGLADEKGITVRGLDAAKDCDALFMETYTSTLSAGSLERLERMIGKDIALAD
REKVEGGVDILDKSKTSTVVLLVPGDPMSATTHVDLRLRAHELGVDTEVIPGVSSLTAVP
ALLGLQIYKFGQTVTIPIPEPNFRPTSFYEKALENFEAGLHTLCLLDIKGDENRYMTASE
GLGELASVENEMRKGLITEDRIVCVVARAGADDALAKAGHFRDMSGQDFGPQLHSIVIPG
KLHFLEAQALVKLAGAPEDLIRD
>A0A151ELR4|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon SG8-52-1|TrEMBL
MTKGCLIFIGLGLNDEKDISLKGLDEIKKCDKVFAEFYTAKLTGTDIEKIKKILGKNIEV
LTREETEKGDRIINIAKEKSVALLTCGDPMTATTHVDIRLRAEKQGIKTKIIHGSSIVTA
VPGLLGLQNYKFGRSTTIAYPEKNYFPTSPYNVIKENKQIGLHTLIFLDIQSDKKRYMTA
NEGMNLLLKMEEKHKGNIIKQDSVICVVARAGSSEPINIAGKFEDLISRDFGPPLHTIVI
PGKLHFMEIEALQTLAQLPAQQGRKLQKL
>A0A256H3I9|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Ib24|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVGELEAYHDVEIEVRPRE
GVERDPEAILSAAAEGDVAFCTAGDTMISTTHTDLRLRAEERGIETRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRESGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWRDELAVVVARAGSPERVVAADRLSALSEREFGDPLHLLVI
PGDLHHVEADALAGLAGASPELVEE
>A0A7J4TT21|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MVLYLIGIGLSDEQDITLKGFEAIKKAEKVYLEYYTSRLQVEPAKLEAFYGKKIMVCNRE
LVEQRAEETILADAQHHDVAFLVIGDVMGATTHSDLILRAKEKKISVIIINNTSIINAIG
NTGLELYKFGKTISIVFPQKNYAPETCYEIIKQNQSIGAHTLCLLDIHTDEKQGTDVKCM
TINEGLQLLLNIEKKRKENVLSENTLVLGCARMGAGAHDQLIKAGTIKNLLNVNFGKTPH
CIVIPAKELHFKEEEMIGLWR
>A0A842W5Y6|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MALYFIGIGLSDETDITLKGLNLIKDSDIVYLENYTSVLSVSVSKLEDLYDKKIILADRN
LVEKKAEETILKDAQGKKVSFLVVGDPFAATTHFDLLNRAKELNIETKIIHNASILTAIA
VTGLQLYKFGKTTSLPFPSKGFEPETHYDALKDNQELNLHTLILLDLNPVENRFMSVNEA
IKNLLDIEAKRKENVFDKDTFCIGCANLGSDNQIIKAGTAEQLLKAEFQGLQCLIVPDEM
HFVEQEVVQQFKE
>A0A842UCM3|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLTFIGLGLWDEKDITVKGLEAVKNADYVYLESYTGVLGVPVSKLKRFYMKDIILASRTI
VEQEAEEILDKAENKNVVFLVVGDPFAATTHTDLLLRAIEKNIECKIVHNASIFSAISGT
GLQLYKFGRTTSLVIPEKNWNPETAYDAIKENKENGLHTLVLLDIKIDFDRTYKTSRKFT
EDKSFRFMKINDAVKLLLEIESRRGENVFEAGTMCLGCARLGSNKQIIKYAEAQELEHLD
FGEPLHCLIVPGELHFMEEKVLELFK
>A0A8J8PH93|diphthine synthase|EC 2.1.1.98|Candidatus Methanomassiliicoccus intestinalis|TrEMBL
MSKPEDMSVKALETLRSSDKIFAEFYTSKLIDSSIEDLENFIGKKITVLKRSDVEEHDTI
IEEAKCGKVSFVTAGDPMSATTHVDIRLRAEKENIPTNLVHGVSIFTACAAAFGLQPYKF
GRAVTIPFPEPGFLPASPYDNILENFERGLHTLILLDIKADESRYMTANIAMQWLLDAEE
RLHKNLITDTSLFCAGARIGSSTQKLVAGSPNSILCVDLGSPLHCLVMPGKLHFMEAESL
CAFAGAPRSILNAD
>A0A7M1USP5|diphthine synthase|EC 2.1.1.98|Thermosphaera aggregans|TrEMBL
MLVFLGIGYSLKHLTLEAIEYLGKADKIVIDRYTSLYEDDPAELAKYTKGEVVYASRKDL
EGEGMSKLIEEARFKTIVLAVPGDPFIATTHDSLRVEAIKKGVEVKVVNSISVLTLIQSR
LGLQAYRFGKTVTLVYPDYFKPYSTIETIYENLNRRLHTIVLLDLRLEHGRAMTIHEAVE
ILLKLDDELENKLDNSLAIGVARLSWRDERVQADLLPRLVKYDFPPPPHSLVIVSTPLPV
EMEGLKLICKLPE
>A0A3R7MD63|diphthine synthase|EC 2.1.1.98|Haloarcula sp. Atlit-47R|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDLETLEDALETSIELRDRA
GIEQDPEPILEAAERESVVFCTAGDTMVSTTHTDLRLRAENRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASQAAAMLSEPFPDTHGVVVARAGSPEPLVVAATLDELATQTFGDPLHLLVIPG
SLHPLEADALESIAGAALE
>A0A2G9MBH4|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_37_12|TrEMBL
MLYLIGIGLADPEDISVKGLNAVKKCSKIYLENYTSKLACSKEDLEKFYDKDIVLANRLF
VESADQLLDDAKKYDVALLIIGDPLCATTHWDILQRAKNQGITTYVIHNSSVINAIGATG
LQVYKFGKTTSMPFPQKHKVETFYDVLKENKSIGAHTLILLDLDPENNKYLTIPRAIDIL
REVEKERQEKLFLPKDLCVGVARLGFSDQKIFAGTVHEVCEEDFGLPPHALIVPGKLHFM
EEEALKMWQR
>A0A7C1P436|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MSGELIFIGMGLGKGDLTIKALNVLRRCDVIFCELYTSKPSGYEIEDLERLVGKKINVLE
RREVEDGDILIKSAFEKRVAFLVVGDPMVATTHVSLRMEAEKRRIKTKVINGVSVITAVP
GILGLQHYKFGRATTLAYPENEYFPLSPYYVIKENLDRGLHTLVLLDINRERGKLMTIKE
GIELLFEMEEKAKGGIIREDMLMCGVARAGSEDCAARAAPAKILRGIDFGDTPHTLVVPG
NLHFVEEEALEVFAGYRKMR
>A0A7J2MXC1|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLIFIGLGLWDEKDITLKGLEEAKNCDKIYAEFYTSKMGIGIEKIEKLIGRKIEVLSREE
VEDGKKLLEEAKEKRICLLTAGDPMTATTHVELRLRAIENGIKTKVIHGISIVSASAGLA
GLQIYKFGKIVSIVKPSKNYFPLSPYDAIKENLKMGMHTLLLLDITNDCMTANEAMEILL
EMEKRKKEGIIKDDTLIVVLARVSSDDALVRAGYIKDLINEDFGKTPHCMILPGKLHFME
AKALVILGNAPPEIM
>R4W2H1|diphthine synthase|EC 2.1.1.98|Salinarchaeum sp. Harcht-Bsk1|TrEMBL
MLTFVGLGLYDEDSITRAGEAAIADADAVFAEFYTSKLLGATVEDLESHHDVDIDVRDRA
GVEQDPEPILEAAESGDAVFLTAGDTMIATTHVDLRLRAASRGIETRVVHGVTAQSAASS
LTGLQNYRFGPATTLPFPDSHGADGLPASVTDTIEDNRDRGLHTLVFLDIKAAQDRFMTA
DRAAALLAAAYGDLLGVVVARAGSPEPLVVADSIESLADRTFGEPLHLLVVPGDLHAMEA
DALAEFGGAPNALLPDRFR
>A0A346PMS2|diphthine synthase|EC 2.1.1.98|Natrarchaeobaculum sulfurireducens|TrEMBL
MLTFIGLGLYDERSITVEGQAALRNADRAYAEFYTSRLIGTTIPDLESYHDVEIEVRDRA
GVEQHPEDILEAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDANRADGLHTVVYLDIKVGHERTDED
EYMTADVGAELLAEEYPELVGVVVARAGSPDPLVEAGTIIDLADREFGEPLHLLVIPGEC
HLLEADALVELAGVERDVLDVT
>A0A2R6FIN4|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_1_69_70|TrEMBL
MLTFVGLGLYDERSVTLAGRNAIRGADRVFAEFYTGRLAGATVADLEAAHGVDVEVRDRT
GVEEDPDAILAAAETGDAVFLSAGDPMVATTHVDLRLRAAERGIETRVVHGTSAETAAAS
LSGLQNYRFGKATTLPFPWAHGAGAPDAAGDEQTGDGSVPDSVLETIAANRERGLHTLVF
LDIKVGTGPSDPGPDQEKFLSADRAAALLADHLEGVGVAIARAGGPDPVVAADALPALAE
RSFGEPLHLLVLPGDLHVVEHDALVELAGAPSSALPDPV
>A0A2H9LAL5|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon CG08_land_8_20_14_0_20_51_8|TrEMBL
MLTFIGLGLQKDGISLAGLREAQEADAIYAELYTSIIPNFNIKELEQKIGKPIKVVTREK
VEPHPEEILESAKISKVAFLVPGDPMVATTHVDLRLRAAKAGIKTKIVHAASIASAAAGL
AGLQSYKFGQSATVPFPDNPSQTPYEVLAGNKARGLHTLLLLDIRAEEGKAMTANEAIEI
MIKLEGKLKKKVFTPDTLAIIVARAGYDDVMIKADKAAKLSKLNFGSPPHVLIMPGKLHF
MEAEALKMFAGAPEGVVK
>A0A7J4PV25|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLFLIGLGLSRDDITLAALDACRHCKELYVDRHTSRLDSPTIEYITSATGKRTLDLTRQE
MEEGARDLVASASVKDIAILCGGDPLMAT
>A0A088E5Z0|diphthine synthase|EC 2.1.1.98|Metallosphaera sedula|TrEMBL
MADIYFVGLGLSKRFLTNASLEVLKGSDVIYADIYTSISCDINEKTLREITGKEIIPATR
EVLETKEKEIYKLLDSGKNVAIAVVGDPMIATTHVSLATGARARGHRVSVIPGVSVHCYM
ISRSMLSSYKFGKSVTVTFPVLDKLDYTPYRVIKTNRELGLHTMVYLDLKETGIMTADLA
LNYLKKMESDIGDKVILDDDLVVIGERLGCADERVRAMKVVDALNQKFGAPPHIIIVPSR
NLYEMEVEGLKCLS
>A0A1H9ZNJ9|diphthine synthase|EC 2.1.1.98|Haloterrigena hispanica|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSQLIGTTIDDLESSHDLEIDVRDRA
GVEQHPEDMLEAAEDEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIDENRADGLHTVVYLDIKAEREEYMTA
DVGAELLAEEYPDLVGVVVARAGSPEPLVEAGTMTELAQQEFGDPLHLLVVPGECHLLEA
DALVELAGADRDTLDIV
>A0A7J4BAN0|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MRGKLILVGAGLSVDLITLRGVKRILEADIVYVDSYTSITLGDLRSFLTTQTGKEAVFLS
RKDIEEKYFETIIKPALEGLKVVLVVPGNPLDATTHVALLSEASRRGIDFEVVPAPGIIP
NALTMSGLMIYKMGKVVTLTYPKSGIISEYPYDVIKDNDLRNLHTPLLTEIDIEKGVKMQ
VREAIEILLQLESMRREGVLSESRKAVAVSGLSGSEQRICFGTLKDLTELPDHEGPHTLV
ITSPKMHFLEEEVAQIISRKYCQLT
>D8J2X8|diphthine synthase|EC 2.1.1.98|Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)|TrEMBL
MLTFIGLGLYDERSITVEGREVLRSADRVFMEQYTSRLIGTDIETLETEHGIEIELRDRA
GVEQDPKEMLAAAEREDVAFLVVGDPMVSTTHVDLRLRAADRGIETRIVHGTTAEAAASS
LTGLQNYRFGPATTLPFPYAHGAEGLPSSVTNTIDDNRERGLHTLVYLDIKHEREEYMTA
DVAAALLAAEYPDTLAVAVCRAGSPEPVVAADSLSELADREFGGPLHLLVIPGDLHHIEA
EALRAFAGAPADLAPLE
>A0A7C4H0Z6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MALHFVGMGLYSEKGLTLEGLELARRADEVYVELYTSLMPGLTLKSLEGLIGRRVIELKR
EDLEGRGAGKIIDEASKLEVVILVPGDPFIATTHLALHLEAVKKGCGGRVIHGVSIASAV
PSVTGLSFYKFGRTVTMVYPDHGSASEEAYEVIKTNRQLGLHTLILLDIRRERGLYMTIA
DALKLLLSVEERRREGVVTDRTLAVGVARVGGRNVEVKADMVKELLSYGFGPPPHVLVFP
GRLHFVEAEALILLAKAPKNLIESQQR
>A0A7J4QX16|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MADDEVNPKETGLMLIGMGPGTVDSMTNEAISVAKSADYRRYEAYTALWPDDELNSLEGI
IGPIEKVMRPEIENPDEILTLAKHSLVAVLIVGDPLQATTHIDLQLQAIEQGINCSVIHG
ISITNLVTGAIGLSNYKFGRQTTLTYPYSGWVATSPLEVIALNRQMGQHTLALLDLDPTG
AGTGQQKPMAPADAVISMKSMIEKVEDNIEEMSTDNDLARLKKQSLEEFIALESCDLPVV
LCSDMGTSQQKMIYTSLADLSELQGGRMNCLVFPASTSDVEEKALLRWLKEE
>A0A7J9NML9|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISDETKVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>L0ABV8|diphthine synthase|EC 2.1.1.98|Natronobacterium gregoryi (strain ATCC 43098 / DSM 3393 / CCM 3738 / CIP 104747 / IAM 13177 / JCM 8860 / NBRC 102187 / NCIMB 2189 / SP2)|TrEMBL
MLTFVGLGLYDERSITVEGQQALRNADRVYAEFYTSKLIGTTVEDLEVHHGIEIEVRDRT
GVEQEPDEILEAAKEETVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPTSVTETIDANREDGLHTVVYLDIKVDHDRTEED
EYMTADLGAKLLAEEYPDLVGVVVARAGSPDPLVEADTMTELADRDFGDPLHLLVVPGEC
HLLEADALVELAGADRDALDVV
>A0A7J4MYJ1|diphthine synthase|EC 2.1.1.98|Methanothermobacter thermautotrophicus|TrEMBL
MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRSVKVLGRG
EIEEERIPLERASELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGL
AGLQAYKFGRIITIPFTADNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTASEGL
MYLLKASEKLDDDTISGETLAVVIARAGSEKPLVRADRIDALVDEDFGDPLHCLVVPAGL
HFIEAEYLVEIAGAPRAVVERMII
>A0A497SK83|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLVGLGIWDEKDISIKGVEVCKKAKDVYMELYTSEWHGSIKAIEGMINKKIKLVARAE
LEDKMDTIIRKSKDNDIAILVPGDPLVATTHTALYLECMKRGIKVRVINSSSIYTAICRC
GLQIYKFGRTVSIPKPAKNFSPLSFYDSILTNRINNMHTLMLLDPEMNVKDALKLLLDAE
RHKKGGIFSEETFIIVCSRLGSDDEKILYGRIKDVMKQHIRNPAALILPAALHFMEEECL
NMIKINKTKSKK
>A0A7J4L5X0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGIGLSDAQDITLKGLETIRKCHSVYLEGYTSLMSCSIDELEKVYGKKIVFLKRE
DVENEREKITLEARTHDVALLIIGDVFSATTHADIILDSRKKNVSVKVIFNASIMTAIGI
TGLQLYTFGKTVSIPYPSKGFAPDSFFEGFLENKQRGLHTLFLLDIKADEGRYMSVPEAI
ALMIAAAEKRKNNGFTKQTLCVGCARLGCGDMLIRSGTAEELLGMDFGKPPHCLIVPGDL
HFIEEEMLEIWKG
>A0A126R167|diphthine synthase|EC 2.1.1.98|Methanobrevibacter olleyae|TrEMBL
MFYLVGLGLFDEKDISLKGVEALKNVDKVYAEFFTSRLFGSNFEAIEEIIGKEIIVLDRT
QVEEESIFLKEAKAMDVALITGGDPLIATTHSDFLVECAREGIDFEIIHGSSILSSAPAI
SGLQAYKFGKVTTIPFPDLEYDYFPKSPYISIEDNLKMDMHTLVLLDIQAHKDKYMTVNE
GLENLMTINDNLDRVGLIDEETLAIGIARVGSKDNLLKAGYIKDLIDFDFGGPLHCIVIP
SKLHIVEAEYLVELAGAPKEILDDI
>A0A7J4N1E0|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLYLIGIGLDKEDISTRALKAVKKCKEVYLEKYTCNFPYSDSELSRVLGKKVLAVNREFV
ENASELLEKAKKKDIALLVYGDPLIATTHLALLQEARKKKVRTEVIHNISVLNAITQTGL
EAYKFGRVTSIPTWQDNYRPTSFYDILKENQKINAHTLFLLDIGLELEDAISYLVKVSTD
RGEGAFTKKTPCIACSCLGTSKQKIKFATAEKLARLKLHKPISLIVPAHLHFVEEAYLKR
FKF
>A0A0F8ISI8|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSLGLHTLVFLDIDKNKGFMSV
NIALELLLEVERKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A662RP87|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDPKDITLKGLEAVRDADVVYAEFYTSPAGVRTIEKLEDAYGRKISLLERE
ELEEDAEGGILELAKSKKVVLLSGGDAMIATTHVDLRLRAIERGIETRIVHAASIASAAA
GLCGLQNYKFGKSATVSPPYKGVISHVPYETIEDNTERGLHTLLYLDIGMRIADALELLE
SVERERGGEMLKRSLLVGIARAGSDDAVVKADYITSLKGYEFGDLPHVLIVTGELHFVER
EALIKIAHAPGSI
>A0A843C087|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDEKDITVKGLEAIRAADTVFAEFYTSPLGGKTIEKMEEEYGKRIALLERS
DIEEHAEEIILKRAKHQNVVLLSGGDAMIATTHVDLRLRAIDMGIETRIIHAPSISSAVA
GICGLQNYKFGKSTTVSPPYREVISEVPYDTIRANKEGGLHTLLYLDLSMSINDALRLLD
AVEDKRGEELLKKSVLVGIARAGSDKPVVKADYLAALKNYDFGELPHVLVVPGELHFLEQ
EALMKIAQAPAGI
>A0A662PRK3|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MPLWLSVSHENLKAVNEMTIYLIGLGLGTSRQLTLEALETAKSLDKIYLDTYTSFIEDSF
LEELSKGLGERLVKADRRMLEEKVSDIIREAGRMEVGILIPGDPLIATTHTSIIAEAAKK
GISFKVIHGLSIYCAAVSASCLHAYKFGRVTTIPKSGIGVETCYRVIAENMERGLHTLVL
LDTADGGLTIPEAIELLLRAEDKFGLGILHEDRLVICLARIGFDDEFKWAGRLRDASQRK
YPPPPHSIIFPGELHFSEREALKAILNADAEVLDEHKPPRLWSSRIEKYLENVRRALEEM
SYLSNDITEDLVNMARSYLEDAERFWESGDLFDALAAISYAEGLLDALRIMGKVEFTWGS
GERVINGR
>A0A076LAT7|diphthine synthase|EC 2.1.1.98|Methanocaldococcus bathoardescens|TrEMBL
MTLKTLKFAKKADKIYAEFYTAVLTGTTIEKIEEVLGKKIHVLSRKEVEYEGYKLIEEAK
DKDIMFLTAGDPMVATTHVDLAIEAKKKGVDVVIINAPSIYSAVGITGLQLYKFGRTASI
VFPEENYFPETPYNVIKENLERGLHTLCLLDIRVDENEKRFMTANEGLKVLLELENRKKE
NIISEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIPGKLHFMEEDALKYLC
ENI
>A0A830F1K7|diphthine synthase|EC 2.1.1.98|Haloarcula sebkhae|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDANRVFAEFYTSRLIGTDIETLESSLGTSIEVRDRA
GIEQDPEPILEAAERENVVFCTAGDTMVSTTHTDLRLRAEDRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEGNRDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASKAAAMLSEPFPDTLGVVVARAGSPDPLVVADTLDELATQTFGDPLHLLVIPG
SLHPLEADVLESLAGAALE
>B8D6P0|diphthine synthase|EC 2.1.1.98|Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)|TrEMBL
MSPLLIFIGAGYSRRHLTQEALESLKSAEKIYVDTYTSMYEDGFNWLRDVNPSAEIVFAK
RRDLEGEGINRIVEEAKEGNIAILCAGDPFTATTHDAIRVEALKSNVSVKVVTGISVVNL
VHSRIGLQAYRFGKIVTLVYPDSFKPYSVIKTIYDNLGRNLHTLVLLDLRLEEGLAMSIP
EAIDILTELDEKQQLMNQISIGVARLGWSSEVIRAGRLIELKRYSYPPPPHSLIIAARLH
PIELESLRYIAGLTITG
>A0A371N0H4|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-6N|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILNAAEDDHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A8J8IRW5|diphthine synthase|EC 2.1.1.98|Thermococcus sp. MAR1|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCDLIFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EEVELHFERIVLSEAKERDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMIREDFGRQPHVMVVPG
RLHVVEAEYLVAFAGAPKEILDET
>A0A495R709|diphthine synthase|EC 2.1.1.98|Haloarcula quadrata|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLEDTLETSIERRDRA
GIEQDPEPILEAAESEHVVFCTAGDTMVSTTHADLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEES
DDTYMTASQAATMLSEPFPDTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPG
SLHPLEADTLESVAGAALE
>A0A3A5VQ21|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MAAKESQSPFLPETGLLLVGMGMGRLEGMTKEAIHAATQADHRRYEAYTALWPEDELARL
EAAVGPVQRVMRPEVEEPEELFALAKDSLVALLVVGDPLQATTHVDLQLRAREVGVECHV
FHGISITSVVTGAVGLSNYKFGRQTTLTYPYGDWIATSPMEVLAANWEQNLHTLALLDLD
PTGLGTGDQRPMRPEDAVQSMRLMWEKLQETVDEPLSEDYVRLAFRQMATKLYLQQSFDD
IPVVLCADMGTPEQAIVTTTLGALGDEKGGRLNCLVFPAGTGEVEEKAVLRWKRGA
>A0A3A5VZ33|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTDDKKTGLALIGIGPGKVSSMTLEAVDLARKADVRLYEAYTALWSESALHELEQEIGSI
ERIMRPTIEQPEDLLEMAKNQLVAVLVVGDPMQATTHIDLQLRAESAGIAVHIVHGISIT
TLVPGATGVSNYKFGRSTTLTYPYGEWIATSPLEVMLQNYSQKLHTLVLFDLDPSGAGTG
DQQPMQASDAAESVAKMVSKYKKMELGEEQEEILEKIDGFEVVLCSDLGTDDQRLQTTTI
GNLGTKSSGRLNCMVLLANLSEIEREAVNRWK
>A0A832V5V8|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MLTLVGLGLGGPESLTQDGIAVIREASALFAEGYTSPLLPETLAWVEQAAGRVRLLSREE
VEQPETLLAAARDSDAVLLIGGDPLSATTHVSLRLQCGEAGIECRVIHNASVLTAVAGEL
GLQHYRFGPVATLVTPQGDYRPLSPVKRVLQNIEAGFHSLVLLDISADNPAAEPRLMTAA
EGAVLLLEGGVATGARACAAARVGRSDQQFWCGALGEMAKAKIGEVPHSIVIPGELHFVE
KEALAALQE
>A0A7M3YH10|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MVGPIERVMRPAVERPEELFQRAQTTSIAILVVGDPMQATTHIDFQLRAEKQGLPCRVIH
GISVTTLVPGSTGLSDYKFGRSTT
>A0A7M3XM40|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MAEDSDKLKQTGLVLIGMGPNMLTSMTEEAIVAAESADFRYYEAYTAIWPIEELDRLERR
VGSIKKVMRPEVEQPEEIFNLAKANNVAVLVVGDPLQATTHVDLQLQAEEHGIDCRIVHG
ISITNIVTGAIGLSNYKFGRQTTLTYPYSNWIATSPLEILAMNRIMGHHTLALLDLDPTG
AGTGKQQPMRPRDAVAS
>A0A3M9ZUU2|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp. H13|TrEMBL
MLWFVGLGVSGFDSVPARGIDVLARADVVYLEQFTSPVPERDVSRIRDVTGGKLVLAKRW
QVEDGAEILKSAKDGEAVLLSYGDPYIATTHIELRTRAAAQGTATGAIHASSALTAIVGE
CGLHFYKVGRVATIMGGESFATPYRTLYKNMAEGGHTILLLEYDQERDFFLDPSDALAGL
LEAEKGQARRVIGESTYCIIASRIGSEDQRITAGMISSLAGTDFGSPPHTVIIPGSLHFT
ESDALGSTCRCVDAPAGNTVEKISAQMIAKYVPMVRAALEEAKSMYAGKYDDVLENAEMY
IRDAEKFLADGHDEVAVLSIGYADGLVDALRMAGGLEPKM
>A0A2G9PTJ6|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG08_land_8_20_14_0_20_43_7|TrEMBL
MVLHMIGIGLCDERDISVKGLEIVKRCDRIFLESYTSRLCCSKEDMEKLYGKEIILADRD
LVEKNSDEIIMPAKDSDVAFLVIGDVFSATTHTDLLLRAHENGVEVDIIHNASVLTSIGV
TGLELYKFGKTTSVPYPEDGFRPETPYEVLMDNLSLGYHTLLLLDLKADLNRFMTVSEAV
RYLLEIEEKRCEGVFTKETRCIGCARLGCGDMKVVYGTASDIAMLDMGGPLHCLIVPGKL
HFMEEEAIKRFDI
>A0A897NA22|diphthine synthase|EC 2.1.1.98|Halapricum desulfuricans|TrEMBL
MLTFVGLGLYDERSITLQGRDALQAADRVFAERYTSRLVGASLEDVEVAHDVEIEPRTRE
GVEQDPEPILTAAENGDAVFCTAGDPMISTTHVDLRLRAHERGIDTRIVHGTTAAAAASS
LTGLQNYRFGKATTLPFESSHGGDGVPDSVIETIEANRERGLHTLVFLDIKVDDDREDYM
TGGEAASLLAANWNGTAPAVVVARAGSPEPLVRGDRLEELAGTDFGDPLHLLVIPGKLHY
VERDALVELAGLPAEAAERLLV
>A0A7D3XU06|diphthine synthase|EC 2.1.1.98|Halorubrum salinarum|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAYHGVDVEVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAADLLAEGWADELAVAVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLADAPEALVEE
>A0A0E3WSC8|diphthine synthase|EC 2.1.1.98|Methanosarcina lacustris Z-7289|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTKPEKMEKLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIEIRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARIISETPYDTIKQNSELGLHTLVFLDIDKEKGYMTV
NLALGLLLEVEAKRGERVIDRAVAVGIARAGSEKPVVKADYAENLKDFDFGKPLHILIVP
GKLHFLEAEALVKLAAGPEELMEDIN
>A0A0E3PWS5|diphthine synthase|EC 2.1.1.98|Methanosarcina mazei WWM610|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVKEADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLSRE
DVEQHPDWLDNARDKKVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGTKVISETPYDTIKQNSSFGLHTLVFLDIDKDKGFMSV
NIALKLLLEVESKRGEGVMDRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMENIE
>A0A2H9NVE7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG_4_10_14_0_8_um_filter_47_5|TrEMBL
MALYLIGLGLGDEKDITLKGAQAIMKCGLVFLESYTSLLSVPLEQLEAAFHKEIIPLARA
DLEENQESRILKPAMSQNVAVLVAGDPLCATTHIDLFLRAKKESIPVEIIHNASVISAIG
ITGLQVYKFGKTTSIPFPRSQGIASPYDTLSQNQEQGLHTLFLLDLDPTKGEFLTIPQAI
SSLFSIEKEKKKHVFTKKTTCLGCARLGAQDQRIMAGSAEALLKQDFGKPPFCLIVPGKL
HFMEEEALALWRV
>A0A0Q0S129|diphthine synthase|EC 2.1.1.98|Acidiplasma cupricumulans|TrEMBL
MLNIIGIGLRGYKSITLEQLDAIKNSDIVYFETYTSISPENTFDYLRSITGKKLIKADRN
TVESSNEIIKNALNSNVSFIVTGDALTATTHNELRLEAIKNGIDVKIFENASIFTAFPSR
TGLFNYRFGPVISLPFIYENFFPLSVYDKIYKNYVNDFHTLILLDLKNGRTMEINEALDI
LIKMEEKRNGNIINYDTFIIAGFNIAREDEYIIAGHIKDVINKKISMSPASIILPAKLND
KEIEFVKIFCDNV
>A0A838NE95|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MGINEYDSLSSGSIEILKNSDTVYIERFTGFLSNEFLEKVKSVVDGYGVSRQKNRIEVQL
VKRWFVEDGRQILENSLKENVSILIYGDPLIATTYNDLLVRAKKQSIPYKVIHSSSGIPS
LIGESGLHYYKFGKMVTIMSDPMSSITVYDTIYNNICLGLHTLILTEYNNDSENGGLSPY
SPSPFFLSPKKVFDLLLERENELKLLNLSENSFVIVAYKVGTESSKVICGKIRSLMNIEF
ESGPNSIIIPGTLHFTEFDSIKNLTVTLDDPVDNSANIDRLSNRMLDKYIPNAKRALFAL
SSLIKGGDITIKKEYTVVLENAENYLYDAENFYKQGRTELAILSVGYAEGLIDSIRFQKG
MNPW
>A0A7J4IQ28|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon|TrEMBL
MLWFVGLGLWDLEDVSLRGRRAIADADRVFLEGYTSRLGGAALAAMEAAWGRPVTVLSRV
DVESRPDEVLEAARAGKAVFLVPGDPMVSTTHVDLRLRAQALGIETRIVHGASIATAAPG
LAGLQNYRFGPATSLPFPHGRWRPTSPVTAIRENLQRDLHTLVYLDIQPGRCMLIPEALD
LLEAAAEETGLEIPLYVGCARVGSPDPVVAAGTADRLRGVDFGGPLHILIVPGELHVMER
EYLEVFAGL
>A0A347APM3|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. BAmetb5|TrEMBL
MLYLVGLGLYDEKDISINGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINILRRE
EVEEENLPLKQAEIKDVVFLTAGDPLMATTHADILMEARKKGIPTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEDNYFPHSPYQVIAENRKMGLHTLVLLDIQAHRDYYMTANEGL
KYLLRVENERNEGIITTDTLAVVIARAGSPEPLVRAHRVGVLVEQDFGGPLHCMIIPGDL
HFLEAEGLVILGGAPEHILPE
>A0A2G9MKQ5|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_34_8|TrEMBL
MTLHIIGIGLNNEKDITLKGLELVQKADFIYLESYTSKLNCSNHDLAKFYNKQIILAHRE
MAEGDNNEIIQNAKDHEVAFLVVGDPFSATTHLDLMQRAKEQGIKVTITNNASILNAVGI
TGLQLYKFGKTTSIPYPEENFHPETSYDVIKMNQSVGLHTLLLLDIKPDRFMSVNEAIKI
LLDIEEKRKENIFTKETLCIGCARLGSDNPTIKSGKAEHILNNDFGEPLHCLIVPGKMHF
MEEEAVK
>D1YX24|diphthine synthase|EC 2.1.1.98|Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)|TrEMBL
MRQTVNNISMRPELGVVTMLTFIGLGLWDENDVSLKGLEAIREADVVYAEFYTSRLMGTT
LEKMEALYGKPVKVLVREDVEQHPKDNVLKDALDKKVVFLTGGDAMVATTHVDLRLRAQK
MGIDTAIIHGASISSAVCGATGLQNYRFGKSATIAFPYKNIISETPYDTIKMNKANGLHT
LLFLDIDREKGYMTINRGVELLLAVEERRKEGVLTDALGVGIARAGSPAPCVKAAKLDEL
KALDFGAPLHIMVVPAELHFLEEEALQALAGLKT
>D5U2J8|diphthine synthase|EC 2.1.1.98|Thermosphaera aggregans (strain DSM 11486 / M11TL)|TrEMBL
MLVFLGIGYSIRHLTLEAIEYLRKADKVVIDRYTSLYEDDLSALAEYARGELVYASRKDL
EGEGMNSLIEEARFKTIVLAVPGDPFIATTHDSLRVEAVKKGVEVKVVNSLSILTLIQSR
LGLQAYRFGKTVTLVYPDFFKPYSTIETIYENLNRRLHTIVLLDLRLEREKAMTIPEAVE
ILLKLDDELENRLDNTLAIGVARLSWRDERVQADLLPRLVRYDFPPPPHSLVIVSNPLPV
EMEGLKLICKLPN
>A0A257MED0|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. NSP1|TrEMBL
MLTFIGLGLFDERDISVKGREAVAAADMVYAEFYTSRLMGTSLAGLEKFHGKKIHLLTRS
QVEVEPFWLEQAKEMDVAFLVGGDAMVSTTHLDLRLRAMLMGIKTRLIHSSSIVTAVSGL
SGLQNYRFGRSTTIPFPYLARGKRIVPETPYRVLQENLARNLHTMLFLDIQRDPVERYMT
AGQGAALLLEMESEAEDKLPPGTLGIGIARAGSDDAVIRADRLSRLKDCDLGGPLHILVV
PARLHFMEAEALRVLAAAPEDALMGAD
>A0A7D5RGF0|diphthine synthase|EC 2.1.1.98|Nitrosarchaeum sp. AC2|TrEMBL
MLWFVGLGISGSKSIPVEALEVLSKADIIYLEQFTSPIGKSDLLKIKKMTNGEIREGKRW
LVEDGTEILKHAKSKKVVLLSYGDPYIATTHIELRTRAIQEKIKTYSIHASSSLTSMVGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTILLLEYNQDKNFFMDPKDALAG
LIETEKGQKRNVINLSTYTIVASRIGFKDQSIISGKISSLKKIDFGKPPHTIIITGRLHF
TESDALKILGKCLDEPKDNSEETKKISIQMMKKYVPMVREALEEITPYYKDQKEFSVILE
NAELYIQDAEKFLEEGQDEVAILSIGYADGLVDALRLAKGLEPKM
>A0A2R6E168|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_3_68_24|TrEMBL
MLTFVGLGLYDERSITVAGREAVRSADRVVTEFYTSELAGVSLADLERFHGVDIEVRDRD
GVEGSPDDFLADAESGDVVFLTAGDTMVSTTHVDLRLRAHERGIETRVVHGTTARTAASS
LTGLQNYRFGKATTLPFERSHGGDGVPASVLETIAANRERGLHTLVFLDIDAAGDAYMRA
DAAAGMLATALDEGDDETVADATSGGNTLGVAVARAGSPSPVVRADALSTLAGESFGDPL
HLLVIPGELHHVERDALAELGGAPERVLPDLR
>A0A1G9C436|diphthine synthase|EC 2.1.1.98|Methanoculleus thermophilus|TrEMBL
MLTFVGLGLYDLGDISVKGLDYVRNADAVYLEAYTSRLMGADVSEMEAFFGKEIRVLARE
DVEQDPHEIIERAASGQVAFLTGGDPMISTTHADLRIRAAAAGVATSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPARGWFPTTPIETIAKNLELSLHTLVYLDIQKDRYMRIPEAIT
ILEEMAEKCGIEPPTLYVGIARAGSENPVVRAGTGAKLKETDFGPPLHVLVVPADLHPME
REYLEVFADL
>A0A2P6VTR5|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon SW_10_69_26|TrEMBL
MSTLAVKGERGVYVRGVDAWPMSSSDEGRLSLVGLGLEADGISLAGRRAARGADRVFLEA
YTAQAPQPVASLEAMVAADVEPLDRAGVEDGDVIVDAARGGHAALLVAGDPLSATTHTAL
RLQAQEAGIAVDVHHAGSVLTAAAGALGLSHYKFGRTTTLVTPQDSYFPQSPYEVVQENR
ERGLHTLVLLDVREDGSFMSAAEGARLLARLEDEQGEGALPDEREVVAIARAGRGDEAAW
RGSLAAIQELDAGEPMHSLVVPGELSPVEEEALAAFATAP
>A0A662MQU7|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MPIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTTIEKIEQQIGKSIKLLSR
EDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSIYSAI
SITGLQVYKFGKSASVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYMTANE
AMNILLQVEEMKKEGIFTEDTLVVILARAGSLAPTLKAGYVREMIKGDFGKQPHILIVPG
KLHIVEAEYLVEFANAPKEILKEV
>A0A7K4A9M8|diphthine synthase|EC 2.1.1.98|Methanosarcinaceae archaeon|TrEMBL
MLIFVGLGLFDEKDVTLKGLEAIKNADIVYLEAYTSRLTGTDIKVMEKLYERKINVLFRE
DVEINTDWLSDALDKNVVFMTGGDTMTSTTHIDLRLRAAEMGIETKLIHGPSIISAVYGL
SGLQNYKFGKSASIPFPYTSSRGVRVVTETPYDTILLNKKSGLHTLVFLDIDPEKGYMTA
KDGLKLLMEVENKKSAENAEDAGTFENIVGNSIAIGIARAGSEKPCVYADFARNFENFEL
GGPLQILVIAGELHLEEAKALVTFANAPVEILDE
>A0A5B2Z493|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosocosmicus sp. SS|TrEMBL
MLHIIGIGISEFDSLPIGSVEVLKNSDFVFLERFTGFISDDFMMKIHNILNDSKESQLNS
GIDIKFVKRWYIEDGREILEKASSNNVSILAYGDPLVATTYNELMVRAKKLSIDVKVIHS
SSGLISLIGETGLQPYKFGKMVTLMNDPMSSITVYNTIYDNLSLGLHTLILTEYNNDDGI
DNFTSSSNPFYLSPKKVFDLLLEREAEIKLANLSTKTFAIVASKIGSDDSQILSGNIDTL
SRLEYEGGPNSVIIPGSLHFIEEDSVRNLTKLLDPPNGNSSRISKLANRMLDKYIPNAKI
ALANLINLLSSTGEGLPKEYESVIENAENYLNDAQTFYNQGKLELAILSIGYAEGLIDSL
RFQKNMNPW
>F8DAS9|diphthine synthase|EC 2.1.1.98|Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)|TrEMBL
MLTFIGLGLYDERSITVEGQTALRNADRAYAEFYTSKLIGTTIEDLESYHDAEIEVRDRA
GVEQEPDAILEAAENEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDANRADGLHTVVYLDIKAEREEYMTA
DTGAELLAEAYPDLVGVVVARAGSPDPLVEAGTMTELADREFGDPLHLLVIPGECHLLEA
DALVELAGADREHLEIA
>A0A7T9HFS3|diphthine synthase|EC 2.1.1.98|Methanolinea sp|TrEMBL
MLTFVGLGLYDLGDIPLKGLDSIRKADHVFLESYTSRLSGTTIRDMEELYGKTITILSRD
QVEVDPDFMLGLAEEFNVALLIGGDPMVSTTHIDLRMRAFRRGIATRIIHASSISTAVCG
LSGLQNYRFGKSCSLPYPHRSWIPLAPAKVVQANRAFGLHTLVYLDIQEDRCMTISEAVD
ILETMAGKIDLSLPLYVGIARAGSESPVVAAGNAARMKEVDFGPPLHILIIPAELHVMER
EYLEMFAGL
>A0A1V4YRJ9|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. PtaU1.Bin242|TrEMBL
MLYFIGLGLYDEKDISLKGIEALKRVDTVYAEFYTARLFGGNIKSLEEMLGIDIEVLSRE
KVEEENLPIIQAKTRDVAFLSAGDPLVATTHTDMMIQAKKAGIKTTVIHSSSILSAAPGI
SGLQAYKFGKVTTIPFSQENYFPHSPYLVIKDNLKYEMHTLVLLDIQAHLDRYMTANQGL
NYLMKVEREREEDVICEDTLVVVVARAGATDPVVRADKIKKLLKEDFGGPLHCLIVPSKL
HFVEAEALVVLGGAPKSIIEDSS
>A0A101EKJ9|diphthine synthase|EC 2.1.1.98|Thermococcus sibiricus|TrEMBL
MVIKMSIYFIGLGLYDEKDITLKGLEIAKNCDLVFAEFYTSLLAGTTIEKIEQQIGKPIK
LLSREDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSI
YSAISITGLQIYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYM
TANEAMNILLQVEEMKKEEIFTEDTLVVILARAGSLTPTLKAGYVREMIKEDFGKQPHIL
IVPGKLHIVEAEYLVEFANAPKEILKEV
>A0A0E3PCQ7|diphthine synthase|EC 2.1.1.98|Methanosarcina siciliae HI350|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLFRE
DVEQQPTWLDEAKDKNVVFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARIISETPYDTIKKNSELGLHTMVFLDIDKDKGYMTV
NHALELLLEVENRRGEGIMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVKLASGPEEIMEETE
>A0A832WR92|diphthine synthase|EC 2.1.1.98|Methanopyrus kandleri|TrEMBL
MGELYLVGGGLSDVRDLTLRALEVLASVELVLVDTYTSVYDVSEGDLKRLLNGFGGDPEV
RMCSRRDLEERFFDLCEGYDRVALLSPGDPMAATTHVALVVEAADRGWDVEIINGVSVFT
AAPSKSGLEMYRFGRTATIPLNVRSVYPYDVLESNRQAGLHTLFLLEVAEDGEFVSVADA
ARYLLEIEREEGRGVLDPSDLAIAVVRLGFEDELVAWGTLEELSDWEPGEPPQALILPAS
RLREAEREYIRRVLPHIRDVRGV
>A0A350QBC5|diphthine synthase|EC 2.1.1.98|Gemmatimonadetes bacterium|TrEMBL
MTERARGVAKECSKRFLEGYTAILPPSEEERLESVVGSWERLMRNDVEEPDELLGLARTR
SVALLIVGDPMQATTHIDLEERCAEEGIGFHVIPGLTATALAV
>A0A6A9Q9L1|diphthine synthase|EC 2.1.1.98|Acidianus infernus|TrEMBL
MLYFIGLGLAKKFLTQASIDAMRKVDVLYLDAYTSLSCDINKEYLEKLLGRQIILADRNT
LENNSKSIIKLLEDGKSVGIATIGDPMIATTHVSLATEAKNKGYNVMIIPGISVHCYVIS
KSMLSSYKFGRSVTVVYPYDKILDTTPYEVIKDNSSRGLHTILYLDLKEGKPMSAKDAIS
LLLQMEEIKKEGIITPSTQIIIGQRLGCEDEEVKALTISEALEYKYKDPPHIIIVPSKNL
HYMEVEALKCLH
>A0A7C4EYB6|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLTFVGLGLGGEGISLRGLRAAQQAEVVFAEFYTSLMPEFDLGQLERSIGKVVRVVNRRV
VEEDPAEILEAARVKEVVFLVPGDPMVATTHVDLRLRAAKSGIATRVIPAASIASAAAGL
VGLQSYKFGPSATVPFPDNRSTRPYEVLAENLSRGLHTMLFLDLREGKRAMTANEAIEIM
FGLEEELRRGVFTPARLSAVVARAGSDDCLVRANRADRLSGEDFGPPPHLLIVPGRLHFL
EAEALQVFAGAPEGVVQWHMRQL
>A0A537G317|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLTFIGLGLNDEKGMTLEGLEEARQADSAYGEFYTNIMPNLDLKRLEKNIGKKVEVLNR
TQLEDEGGEKLLKAASKQRVAFLVPGDPLIATTHISLRLSLAKMGIPSRVVHAPSIVSAV
CGATGLQSYKFGKSITVPRDQPLPRSLLDTISDNSHRGLHTLILLDVQAGKTSQMTIRDA
ITKMTTADPHLETRVAVGLARLGSRDEKVKASKMKILTGEDFGNGPQSIIVVGRVHFMEA
EALEVLCGAGEEDLRELS
>A0A842MQ24|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLYDEAGISLKGLEEVKSADAVFLELYTSLMPGFSMNRLTSLSGKNPQILS
RRMIEDENGEVLLRAAETGKAVLLVPGDPMIATTHIALRLEAEKRGIKTRIVHAASIVSA
AIGLSGLHNYKFGKSVTIPFPDNFSETPYNVIAENKERGLHTLCLLDINAEEKRYLTINE
ALNLLLSVEEKRRKGVVTSQTIAVGVARAGSQNPTVKAGTIETLIKYDFGSPPYTLIFPG
KLHFMEAEALILLAKAPENIRGLSK
>A0A7J2N5I7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLIFVGLGLYKLNDLTLSGLSWMKAADILYLDTYTSIIPGFSMKLLRELIGKDIVPLRRK
QIEEEGERILMEAKDKIVVLLVPGDPFVATTHMRLRLDAVEKNIETKVVHAPSIISAISG
ETGLFNYKFGRTVTIPFPYENYLSETPYDVVKENLERNLHTLLLLDADVERNRYMSINEA
LEILIKIEGKRREAIITMDRLVVGVARIGADDSIVIARPIKELLKRDFGPPPQSIIIPGR
LHFIEAEALVKLAGAPRRILK
>A0A7C3XGP4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLTFIGLGLHSELSISLEGLEEARRADIVFAEFYTSYMPGFRLANLERLLGKKVHVLSRR
DLEDEAEEKVLEPARRCRCVLLTPGDPNVATTHIALRLRAEKEDIRTFVIHAASVASAVA
GVTGLQSYKFGRTVTIPFKSTSTSDVPYDNICENMMRGLHTLALLDIDSEAGRYMTVNEG
LEQLLDVEGRRGCGWLGLDRPAVGVARIGSREMRVKADTIGNLGGYDWGGPPHCLVFPGR
LHFMEAEALHILCGADMEILRGLM
>A0A7J3NPH0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELIFIGLGLWGADDITLKGLDAARSADEVYFEAYTSLIGDLTKDSLDNLIGKNVRFLT
RKDVEENVRELLYRARDKRVAILVPGDPMVATTHIALRLEAEKLGVKTRVIHGVSIYSAA
PSICGLENYKFGRSVTIPFPEENYFPDTPYFVVRENVDRGLHTLVFLDVRAEEKRFMTVN
EGVAILLKLERKLSPQEPLLEKTIMVGVARAGSKNPTVKADYPHNLISYDFGSPPHVLIV
TGKLHFKEAEALRLLAAAPLSAP
>A0A497MPW4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEGELIFVGFGLGDSGLTVKGLETVKNADKVYVETYTNYTPDWVIEELEKLSGRRFERV
SRKELEELGGAALLEAASDSKVVLLVPGDPFMATTHIALRIEAEKKGIKTRAVNSSSIVA
AAAGACGLQIYKFGESATVVFPDSDTVSMKPYDTVLKNLERGLHTLLLLDYRAEENRAMT
VNYALRLLRSLEKIRGMQVFIDDRLVVGLARLGYDNYKVKGGSLKDILNEDFGEPPHCIV
IPGSLHFVEAEALKVLADVKEISPREEINARSYIPLDRLNRYISGVEKVFRDIRLLESSR
LVDRGDIDKALDWARSYYEDSQAFRDRGDLVSSLVAVAYCEGILEGLRLLNLVEFKWEGE
V
>A0A2R6GRE9|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_1_68_17|TrEMBL
MLTFVGLGLYDERSITVAGRDAVRSADRVFAEFYTSRLAGTTVERIEEYHDVTVEVRDRG
GVEQRPGEILDAAREDNVAFLTAGDAMISTTHVDLRLRAIERDIDTRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFEETHGGVPASVVETVAENRERGLHTLVYLDITVDEDEERYMTG
DVAAGLLAEPCDDPLGVVVGQAGSEDPTVAADRLSALADREFGPPLHLLVLPAAPHPLEA
DALVELGGAPRTTVEN
>A0A842NL83|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MDEEDSGLWLIGLGPGDLDLMTVAAVEKSKKCDYRFLEGYTALLPDNQLEKLTGLVGGFE
KVMRPGVENPKEILDLAKKSKVALMVVGDPLQATTHVDLQLRAEALGVNCHIIHGISITT
IVTGAVGLQSYRFGRQVTLAYPYGEYLATSPFNLILENRERNLHTLVLLDLDPTGMGVEI
QKPMSPKVAIDVLIRSAKKIGVDIDDWKIVLCTDMGGENQTI
>A0A7K4ADV2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MSVRALQALHKCDEIFAEFYTSRLIDTTIDELEDFIGRKITVLGRSELEESDVVIEAARR
NSVALMVAGDPMSATTHVDIRLRAVEEGIETKLIHGVSIFTAAAAAFGLQPYKFGRAVTI
PFPEPGYLPSSPYENILENHTRGLHTLVLLDIREDENRYMTAAQAAKWLLDSESRLRGGL
INEDSILCAGARIGSHDQKLLAGSYSRIIEANIGPPLHCVIVPGNLHFMEAHALVQLASA
PTNILQD
>A0A327HCW5|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MAAGLILIGMGLGGIAGMTRAAIDAAKSADHRRYEAYTALWDSQSLEELESEIGHIQKVM
RPEVEDPVELLELAKNSTVALLIVGDPLQATTHVDLQLQAXEAGVACSVIHGISITSLVT
GAVGLSNYRFGRQTTLTYPYGGWVATSPLEVIAMNRYQGLHTLVLLDLDPTGEGVGGQVP
MQPQDAVNAMMAMSEKLSETIQEMQQDLPLEQIRXEACKQIXLDIANLMVVLCSDMGTKE
QAITYAKLSELSNVKSGRLHSLVIPANLSDVXNSALHRWAKE
>A0A842P2D5|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MTHHTRKSDKHYSLDDDGGWTMTNFESGLWLIGLGPGDLSAMTTASIEAAKSCNYRFLEG
YTALLPSGEGAKLVEIVGEYELLMRPGVENPDQLLELASENAVALMIVGDPLQATTHVDL
QLRAKAAGINCHVIHGISITTIVTGAVGLQSYRFGRQVTLAYPYGDYLATSPFELILDNL
QRDLHSLVLLDLDPTGMGVDEQNPMSPAMAVDILRRSADKIGENIEQWKIVLCSDMGRPE
QRIFYGTLDDVQLINNGSIHCIVIPGRLDELEVEALARWN
>A0A6G1Z5A1|diphthine synthase|EC 2.1.1.98|Haloferax marinisediminis|TrEMBL
MLTFIGLGLFDERSISVEGREALADADRAFAEFYTSHLVGATVEDLETYHDIDIEVRDRA
GVEQDPEEILAAAEEEHVAFLTAGDTMISTTHVDLRLRAEARGIETHLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRERGLHTLVYLDIKVDWEGRRGV
EVEGDQYMTADYAAELFAEHWDGDALGVAVCRAGSREPVVAADRLSELAKQDFGDPLHML
IIPGEVHHVEADALMGLGGAPEDLFDYDER
>A0A7K4BJ35|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
MLTFVGLGLYDLGDISLKGLECIQKADTVYLEAYTSRLMGTSVAEMEALFGKEIRVLGRE
DVEQDPRDIVESAVRGCVAFLTAGDPMVSTTHADLRMRAAAAGVATSIIHASSISSAAPG
LSGLQNYRFGKSCSIPFPAKGWFPTTPVETISANLDLGLHTLVYLDIQETRYMRIPEAII
LIEEMARVRKIDPPALYVGIARAGSRRPVVAAGTSARLKEIDFGSPLHILIVPADLHPME
REYLEVFAGL
>A0A7T9I0W2|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MFRLIGIGLNPRQLTLEALHAIQASDKVYVENYTSKFAEGDLKKLETIIQKPIHLLQRKD
VEDYSESFLSEAKTHSISLLIFGNPLTATTHISLLEYCKQEKIHYEVIPGISIFNYRGIC
GLDEYRFGRTTTFVFPREGDEPLSPFDVIVKNKAMGLHTHCLFDLHPDAQRFMSVDEAIG
FIRRAAVAREVDIHDWVGVGLGGMGHSKQLVRAGKLDAIEKHAWNVFPQSLIICGHLQEY
EHEALQKLGGMK
>A0A523AQA9|diphthine synthase|EC 2.1.1.98|Archaeoglobi archaeon|TrEMBL
MLTLVGLGLQDFRDITLRGYEAVKKAEEVYLDTYTSRISSSIEDLQRFFGKKIIEAKRSD
LEEGGRKIIERARERDVVILIPGDPTIATTHIALVLEARKANVETRIINNASIINAVCSL
TGLQNYRFGKSATISWFRSRAFIDTIYANLSIDAHTLLFLDLNPPMTIKEAVSRILELDS
GFKDHFAVGVARAGSEDAVVKCDRLKELAYFSFGEPLHSLVILSKKLHVLEYECLVYFAS
APEELREWVL
>A0A7C2Z8X8|diphthine synthase|EC 2.1.1.98|Caldivirga sp|TrEMBL
MAGTLYIVGVGLGPGQITQEAINVLRSVGEVFIEEYTSMFETSLGDHIAKVVGRMVVKLS
RRDLEEESGRVIINAIRKRGSAALAVIGDPMLATTHSALVTQATQLGIRVRVINGISIVC
AAVSQAGLSPYKLGPVATVTYERGGVLSKRAYEVLAGNISRGLHTPLLLDIKDEGGFMSI
REAVDVLIRLEEEVKQGIVSDDLAAVFESRIGWSDQAIVVASLTNPPDLKPPSVILIPGL
LNPVEEEYLRVVHGAGEELLRRHINHVKALMRAM
>A0A2U9IV76|diphthine synthase|EC 2.1.1.98|Metallosphaera hakonensis JCM 8857 = DSM 7519|TrEMBL
MSDMFFVGLGLSKRFLTNASIEALRNSDVIYADVYTSISCDLNIQTLREISGKTVFPATR
EILEMKEKEIYSQLDQGIKIAIATIGDPMIATTHVSLAAGAKRRGHRVIVVPGVSVHCYM
ISKSMLSSYKFGKSVTVTFPYLEKLDYTPYNVIKENRERGLHTLVYLDLKETGVMTADLA
IGLLRRMEENKKEGVITEDDIVVIGERLGCQEERIKALKVREVSAEKFGNPPHIIIIPAR
NLYEMEIEGLKCLS
>A0A6G3LFS9|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon|TrEMBL
MQKCDGEIFFVGLGLMEKHITAEAAEALRAADKIYVEGYTSFYYPDVYTSLKNLGIPEEK
IKNVSRRDLEDNSGEELLRHASMGNKVALATVGDPFIATTHLALRLRFERYGCRVRYMPS
VNIFSYSISKTGLFSYKFGESATVVYPRDGILSTYPYLVLEENLKRGLHTFFFLDIDEKF
GPLNAAEAVKLLLRMESEERRGAFTVGTDVIIVERASWPDERIILTSAGKAKEKRLNPPH
SLIVPGKLHFMEKESIEVFRT
>A0A7D5P7Q5|diphthine synthase|EC 2.1.1.98|Halosimplex pelagicum|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRAADRVVAEFYTSKLAGATLADLEAAHDTEIEVRDRA
GVEQSPDDVLDDAADSDVVFCTAGDTMISTTHTDLRLRAHDRGIETRVVHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHAGDALPESVVDTIEANRERGLHTLVFLDIDAENDDYMRA
DRAAARLADAYEDALGVVVARAGSPDPVVRADRLSALAEESFGDPLHLLVIPGDLHLMER
DTLAALGDAPTDLIEGLVV
>A0A151DUC9|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon SG8-52-4|TrEMBL
MHKGRLTFIGLGLYDERDISLKGLEEIKKSDKVYAEFYTSKLTGTDVKNIEETIGKPIEI
LSRDETEKGEKILNSAISKNVVFLTAGDPMTATTHVDLRLRAIKKEIKTKVVHSSSIITA
VSGLLGLQNYKFGRATTLAYPEKNYFPTSPYDIIKENQEIGLHTLILLDIQEDKNRYMTA
NEGLKLLIKMEEKQKSDLIHENSLFCIVARAGSDKPIVTSGSIKDLIKKDFGPPLHTMVM
PGKLHFMEIEALQTLAQLPAQQVKKLQKL
>A0A7D5EEQ8|diphthine synthase|EC 2.1.1.98|Methanolobus zinderi|TrEMBL
MLTFIGLGLFDEKDISVKGLEAIRKADMVFAEFYTSVLMGTTVERLEELYGKKVHVLLRE
DVEQNPDWIEHAKEKDVVFLTGGDTMVSTTHVDLRLRAQDAGIETKLIHGASIASAICGL
SGLQNYRFGKASTIPHPYTSSRGRTIISETPYDTIKANKERDMHTLIFLDIDREKGYMTV
NQAMELLLEVEERRGEGVMENAITVGIARAGSPGPIVKADYIHKLKDHDFGGPLHIVVIP
ADLHFIEAEALVKLAGAPTEIMSTVED
>A0A7J4JN85|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MENGKLYLVGLGISDEKGTSLQGLQKLKECWKIYAESSANLLPEGTLARLEKLVGKPIEI
LSREQVEGEKEILQSASSAPTALVVSGDPMIATTHISLVLAAKKKGIQTEIIHASSILSA
AIGESGLQAYKFGKTTTLAYWRENYKPMAAYDTIAENLSRGLHTLLLLDIDEKLGPMPPS
EAARILLEMEKQGKKGMLTLETKVVLLQGVSYGGEQRKVFAPLLAFSQMSAMRPCVLILP
GALHFLEEEFLQSL
>A0A497FS75|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLVFVGLGLYNCADLTLRGLEVLRHADKVYLDTYTSIVPGFSIEVLESLIGKKVVPVDRS
ILEGRKLINILEEAREKNVALLVPGDPFIATTHISIRLEAEKHGIKTEVVHAPSVISSAI
SATGLQVYKFGKIVTLVYPDPEIGFYPISSYEVLKDNFNRKLHTFFLLDLREDRKMTIAD
AVDVLFLLEEKVGDGIISSETLGIGMARIGSPDLILKAGTLEDLKKHDFGPPPHSLIIPG
LLHPMEAEALLLLCNANKEMIEKWMKKIK
>A0A7J2T032|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MTLVLVGMGVHGPRGIPVGALEDLRACGRVLLDAYTTPMDVERALEELRSILGVEVTAAG
RDLLEDAPRISREAAAGCLGIVVPGDVFTATTHDALRQEAVRRGVEVRVWHSSSVVTSAL
GRLGLHVYKLGFIGTLAEGPPQSAYRLYFGVASALRNGQHSLLLLQHDKEGGGLSVAEGL
RLLRQAEDSWRLGAFSPDRVLIVASRLFSSSEAMRILRMEEALDADFGEHPHSVIVPGRL
HYTEADSLRLILGAPDEVLSEAGRVPASLGSRLAESAIGKTRNALARFRGAVPASPGIGI
LMENVESYLYDAERFLREGNVELALAEAGYAEGLLDSLRLLGYARIDWRGPGDRRAPEGA
SYAVNPEATGSSGFRASLSTTVA
>A0A5E4HPW4|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MALILVGLGLFNERDITVGGLDALNRAHVIYAEMYTNLWGGSLKTLEGWCEKEIILLPRS
GLEEGAQKIIEEATGWDVAVCVPGDPLAATTHLHLVAQARKRGIQVRIVHASSIFSAVAE
CGLHLYKMGRTTTLAYPEGSYRPKSPYLVIADNKEAGLHTLVLLDVKADEGRYMTVTEGL
SLLSEFESEERKGVCGPDSLVVGIARLGSDDAVIKAGTLKDLLKFDFGQPPHCLIIPGKL
HFTEEEMLDSYK
>A0A5E4K2U0|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLYLIGLGLNEKSISLEGLEAIKKCKKIYLDNYTVNFPYSEKVLEKIIKKKIISANRDII
ESDKLIKEAKRVHSVPSHSSQKRQMKENNVALLVYGSPLTATTHITLIEESKKNKIKCEI
IYNASIFDAIAETGLQIYKFGKIASMPKWQKNFTPSSFMEFVKQNLEIGAHSLILIDISL
DLKDAIEELEKSAEEYNLKLGKIVICSRMGTKDKKIIYDKPENLKSREIKKPYCMIIPSK
LHFMEQEVLEKF
>A0A5E4JQ03|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLFLIGLGLNADSISEEGLNLVKKCKKIYLENYTVELPYSTQHLEEVIGKKLFPADREFV
ESLKIIDEARKLDVALLIYGNPLMATTHITMVQESNLSGVKCKVVHNATVLDAVGVTGLQ
IYKFGKIASMPKWDEKKKFTPDSFMKIVKENSSIGAHSLILVDIGLQFPDALNELKISAK
NQEVSLSKIIVGQQIGTKNQKILYRPLSELEGFKGVKAPFCFILPGKLHFVESEYLESFQ
KE
>A0A847UXV3|diphthine synthase|EC 2.1.1.98|Methanothrix sp|TrEMBL
MLSFVGLGLYDERDVSVKGLQTIMDADLVYAEFYTSRLMGATPEKLARFYGKEIRLLSRE
EVEVSPEDWMGRAKEEKVAFLVGGDPMISTTHLDLRLRALRMGIKTRIVHSSSIVTAASG
LVGLQNYRFGRSTSIPYPYVAGGRRIVAMSPRDVVVENLARDLHTLLFLDIQPERYMTAG
EGAALLLEMEAAAGADRLNSSLGVGVARAGSEDAVVVADWLPRLPERDLGDPLQILIVPA
RLHFMEAEALVALAGAPPEILEVAEP
>A0A832W6T3|diphthine synthase|EC 2.1.1.98|Methanocaldococcus jannaschii|TrEMBL
MLILAGLGLYDENDMTLKTLKFAKKAEKIYAEFYTAVLTGTTTEKIEEVLGKKIHVLSRK
DVEYNGYKLIEEAKDKDIMFLTAGDPMVATTHVDLAIEAKKKGIEVLIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIDENEKRFMTANE
GLKVLLELENRKKEGIINEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIPG
KLHFMEEDALKYLCENI
>F0TAR8|diphthine synthase|EC 2.1.1.98|Methanobacterium lacus (strain AL-21)|TrEMBL
MIYFIGLGLYHETDISLKGLIALKQVDHIYAEFYTAKLFGGNIKNLEELVGQEIQVLTRE
EVEEGNIPIQKAEVDDVAFLIAGDPLIATTHSEMLIQARKMGIKTNVIHASSILSAAPGI
AGLQAYKFGKVTTVPFTEKNYFPHSPYMAIKANMESNLHTLVLLDIRAHEDRYMTANQAL
EYLLQVESIKNENVTTEDSVAVVVARAGSDEPVVKADKIKNLINQDFGGPLHCLMIPADL
HFMEAEALVELADAPKELFEDID
>A0A6B0VKJ6|diphthine synthase|EC 2.1.1.98|Natronorubrum halalkaliphilum|TrEMBL
MLTFIGLGLYDERSITVEGRETLRNADRAYAEFYTSTLIGTTVDDLEDTHDIDIEVRDRA
GVEQHPEDILTAAESEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDANREDGLHTVVYLDIKVDNEAATNR
LETDETLEEYMTADTGAELLAEEYPDLVGVVVARAGSPDPLVEAAPMGDLAERKFGDPLH
LLVVPGDCHLLEADALVELAGADRADLDVV
>A0A497HCK1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGSLTFIGLGLYDEKDISLKALEAIRNCDKVYAEFYTSKLTGTTVGEIEKVIGRKINVLS
REETEDGRIILDDASHKSVVFLTGGDPLTATTHLSLRLQAIEKGIKTHVIHGSSILTAVP
GLLGLQHYKFGRTTTLVYPESNFFPLSPYEIIKENREHGLHTLVLLDIQDNRFMTINEGI
EILLKMEGKKDDGLFDKDSIICGVARAGSPNPTVKAGRIRDLEEYDFGPPLHTIVIPGDM
HFLEIEALEVFADLPASISKKLQKL
>A0A842ZT22|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MVKGRLVFVGLGLYDEADVSLKGLRELKQCDEVFAEFYTTKLGQFDRKAFEKLIGKKIEV
LSREETEKGDRIIDAAVQNHVVFLTGGDPMIATTHVDLRLRAMKQGITTKIIHSSSIVTA
VPGLLGLQNYKFGRTTTLAFGEKEYFPTSPYTVIYNNKEMGLHTLVLLDIQVEKNRYMTA
NEGLELLLKMEDTLRKCLFTDDTIACVVARAGAPDPVVAANTINVLRKKDFGPPLHTLVI
PGNLHFMEVEALELCAGLPPEVGKKIQKL
>A0A497HIY9|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
IEAKKRGIDTKIIHNASIISAAPSMAGLQNYKFGRSTSILFPEEKFFPLTPYDVIKENLE
RGLHTLVFLDIKDDKLMSPNEALKILLKMEKLRGDNIFTEENKIVVLSRIGTEDSRIFFG
KVGELLNLDFGPPPHTIIVLGKLHFMEEEYLKEFGNATSR
>A0A662LPA6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLSFVGLGLWDERDITVKGLEEVRNCDVAYAEFYTSKMGVGIERIEELAGKKIHVLSREE
VEDGERILHEAEKKHVCLLAGGDTMAATTHVDLRIRAVERGIPTRVVHGVS
>F4BSZ6|diphthine synthase|EC 2.1.1.98|Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6)|TrEMBL
MLHFVGLGLYDERDISLKGLEAVRAADCIYAEFYTSRLMGTTLEKMEALYGRKIHPLSRQ
EVEVDPSWLEEGRNKDIVFLSGGDAMVSTTHLDLRLRAIKMGIETRVIHSSSIVTAVSGL
CGLQNYRFGRSTTIPFPYVSRGRRIIPQTPYQVLRENQKRNLHTMLFLDIQMEPVERYMT
ANEGTALLMEMEANAGESGLMEAIAVGIARAGAPDASVKADLLPRLQGYSLGGPLHILII
PARLHFMEAEALRILADAPADAVQC
>A0A1H6S7D1|diphthine synthase|EC 2.1.1.98|Halohasta litchfieldiae|TrEMBL
MLTFIGLGLYDADSITCEGRHALRAADRVFAEFYTSSLLGATVADLEAAHDVDIDVRERA
GVEQDPEVILSAAEAEDVAFLTAGDTMISTTHSDLRIRAEDRGIETRVIHGVTAETAASG
LTGLQNYRFGKAVTLPFPFVHGAGDVPPSVIESVEANQERGLHTLVYLDIKVDYHKRRGG
PDLDDPYMTASYASELLAAEWDEDALAVVVARAGSPEPLVAADRLSALADREFGEPLHLL
VIPGDLHHVEADALAALADAPAELVEVDD
>A0A7J4N639|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon|TrEMBL
MGELIFVGLGLGGVDDLSARTVRSLKECDQVFGEFYTSKLIDSTPDDLEKVIGKSIVRLR
RREVEEEETVIEAAKKGKVAFVTAGDTMAATTHVDLKIRAMEEGVRTTVLYGVSIFTACA
SALGLQPYKFGRAVTIPFPEPGYTPLSPFENIYENWSRGLHTLVLLDIREEEGRYMTANQ
AVRWLIDAEKAKGLGMITGSTVICAAARIGSRTERVSAGYPSKMLDEDMGPPLHTVVVPG
KLHFVEAYALVKFAGAPEEIADDQNL
>A0A2H9N0B9|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon CG15_BIG_FIL_POST_REV_8_21_14_020_37_27|TrEMBL
MLNLMGLGLSDEKGLTLEGLETLKKSDKVYIELYTSKWFGSIENLEKMTGKKIMQLKRPD
LEENLEKILKEAKNQTISILILGDPLVATTHTALLIEAKKLGIKTRVIHNASIYSAAGET
GLHLYKFGATVTIPFLEKMNNQFPKSVSKIIRDNKGRDLHTLCLLDLISEKEKYMTPSEG
MEVLLKSDDITQEDEIVIFGRAGSEEPLIAYGKIKNLIDKDFGNPPFVLIILGKLHFTEK
EYLEYHRAD
>A0A7D5GMZ7|diphthine synthase|EC 2.1.1.98|Haloterrigena sp. YPL8|TrEMBL
MLTFIGLGLYNERSITVEGRDALRAADRAYAEFYTSELIGTTIDDLESYHDTDIEVRDRA
GVEQHPDDVLAAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKSTTLPFPYAHGADGLPASVTETIDDNRSDGLHTVVYLDIKVGRGSAGSQ
KASHSDDTADRDEFMTADVGAELLAAEYPDLVGVVVARAGSPGPLVEAGTMTELATREFG
DPLHLLVIPGECHHLEADALVELADADRAALDIV
>A0A1I6Y5P8|diphthine synthase|EC 2.1.1.98|Methanosarcina thermophila|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTSLERMEKLYGKKVFLLSRE
DVEQHPDWLSEARNKKLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGRSASIPHPYESGRGTRVISETPYDIIKQNLELGLHTLVFLDIDQEKGYMTV
NTALELLLEVEEKRGEGVISGAAAVGIARAGSEKPVVKADYVENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAGAPIGFMKEAE
>A0A662IKX0|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MIALLYFVGLGLSSKDISLKALDVLKRADRIYVDNYTSLFVNSDFKVVLSEYVDQAKVSF
VDREFLEGEDYRRILKEAALRDIVIAVIGDPFIATTHIFIRIEAEKAGIPTKVIHAPSIL
SAGISATGLQAYKFGKSATIVFPEEEFFSTYPYEVLYDNLLRGLHTFFFLDIKVERSRLM
RVEDALKLLLRMEEFENKGIIDLGALGIGLGRIGSDNEVIRAGSFKDLLQYNFGPPPHSL
IIPGDLHPLEEEVLIYICGAPKTVVKHWSSRVKKLRSKST
>A0A832VX20|diphthine synthase|EC 2.1.1.98|Methanobacteriales archaeon|TrEMBL
MLYIIGLGLYDENDISIKGMKTLKECDRIFAEFYTAKLKDQSLSTIKEKTGKDIQIIGRK
EIEEEMKPLKYAKREDVALLVPGDPLAATTHSTLILEAQRKNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEENYFPHSPYLTIKNNLKYDAHTLILLDIKAEENKYMNANQGL
KYLLKVEEERKENIISLDSLAVVLARVGSSNPLIRADRIKKLIVEDFGGPLHCLIIPSKL
HFLEAEYLIEIGRAPPEILEGRI
>A0A7C5U9C6|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MKGKLYIVGIGLTPEYLTIRALKILRRVKKVFLDSYTSLLVDDVKLKEVLGSDYEMLGRR
DLEDLNGEKVFNALNEGDVALLSPGDPLIATTHVNIVIEARRRGYEVEIVPGVSIVSAAV
SFTGLMIYKLGKIATVTYPKDGILYEYPYDVVKENSLRNLHTLLLLEVDVDKSIYMSVKE
AIQILLRIESLRREGVITSDRLAIGISRLGGEDMKVCPDSLGNLMSMDLGGPPHSLIITA
PKLHFIEEEVLKVVKDVYCR
>A0A650CGP3|diphthine synthase|EC 2.1.1.98|Sulfurisphaera ohwakuensis|TrEMBL
MPTLKLIGLGLSAKFVTREAIDEISKCNVVLFESYTSLSCDINLDFIKFLNKNVIIVDRK
FIENNIKEIIKLLKEKEDVCIVTIGDPMIATTHVSLIVEVKDKGYNFKVIPGISVHCYII
SKSMLSSYKFGKSVTITYPYNNKIDTTPYDVIYDNFIRGLHTILYLDLKEDKIMTAKEAV
ELLIEMEKIKKQGLISDDRIIIVGQRLGCDDEEVVALRLKEVFNYKFKEPPHIIVFPTDK
LHFMEVEALKCLMK
>A0A7J4DEL9|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPSSEANTLIPGASHPRLRIWPRASSTWWLGTSRWRITFMTGSGAARFTMTDDEPAPGLW
LIGIGPGDLDHMTERARSVARGCSKRYLEGYTAVLPQREEERLESVIGPWERLMRDKVEK
PAELLASARSKAVALLVVGDPMQATTHIDLEARCAEQGIGFYVIPGLSVTALAVSLSGMQ
SYRFGRQVTLPFAVGDYLPTSPLEILCNNFESGLHSLVLLDLDPTGMGVERPRPMSPAEA
VGLLEKMVERLEGGEDGLRASLERPVREWSGILLSDLGTKQERVLSGHLGDLAELRGGTV
HAFVLPTEFNGLEEEAFERRRIGG
>F7PN64|diphthine synthase|EC 2.1.1.98|Halorhabdus tiamatea SARL4B|TrEMBL
MLTFVGLGLYDERSVTLAGRDAIRAADRVFAEFYTSRLVGASVDDLEAFHDTDIEVRDRA
GVEQDPEPILDAAREGDVVFLTAGDTMISTTHVDLRLRAEERGIETRVIHGTTAQAAASS
LTGLQNYRFGKATTLPFERSHGGTGVPNSVIETIEANRERGLHTLVFLDITVESDHETYM
RGEQAASLLAEHWRADALGVVVARAGSPDPVVRAGRLSALAETDFGEPLHLLVVPGSLHY
IERDALEAIGEAPAEVLEENVAE
>A0A7G9YGY0|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MLTFVGLGLYDEEDVTLKGVRAIRDADMVFAEFYTSKMMGTTIERMESIYQTNVTVLSRN
EIEVDPAWLHHAIEGDVVLLTGGDPMVSTTHVDLRLRASDLGIETAIVHGSSIASAVAGI
TGLQNYRFGKSATIPFPYHGRSKTVISETPYNVILQNRDNDLHTLLFLDIDPKQGFMTIP
HAIELLMRVDESKALEEALGVGIARAGSLDVVVGCDRLIRLATFDFGAPMHVLIVPATLH
QMEAEALVRFAGAPGDVCAGGAF
>A0A660HU52|diphthine synthase|EC 2.1.1.98|Methanosarcina flavescens|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTSLERMEKLYGKKVFLLSRE
DVEQHPDWLNEARDRKLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRVISETPYDIIKQNSELGLHTLVFLDIDQEKGYMTV
NTALELLLEVEEKRGEGVMHRAAAVGIARAGSEKPIVKADYAENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAGGPIGFMKEAE
>A0A089ZGM8|diphthine synthase|EC 2.1.1.98|Methanobacterium formicicum|TrEMBL
MLYLVGLGLYDEKDISINGLEAIKSADVVYAEFYTARLFGGDLKSLESLAGVTINILRRE
EVEEENLPLKQAKTKDVVFLTAGDPLMATTHADILMEARKNGIPTRVIHASSILSAAPGI
AGLQAYKFGKVTTIPRPENNYFPHSPYQVIAENRKMGLHTLVLLDIQAHRDYYMTANEGL
EYLLRVENERNEGIITTDTLAVVIARAGSPEPLVRAHRVDVLVEEDFGGPLHCMIIPGDL
HFLEAEGLVILGGAPEHILQE
>A0A7J4HUJ0|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYVIGIGLADEKDISVKGLEIVKKCEKIYVENYTSLLQCSHTNLEKFYGKKIIPAPRE
LSEQGAEKIVQEAKKKNIAFLIIGDPFSATTHIELFKLAKENKVPVKVIHNASILTAVGI
TGLQLYKFGKTTSIPFIEEYPNVETPYNIFRENNLLGSHTLFLLDLKPDQNKFMTIHNAL
EILETIESRKKENFIKENMLVIGCARLGADDFMIKAGALKDVKNMDFGKPPHCLIIPGKL
HFLEEEMLKVWK
>A0A1X4H7Z0|diphthine synthase|EC 2.1.1.98|Halorubrum ezzemoulense DSM 17463|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGNAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>H0AA52|diphthine synthase|EC 2.1.1.98|Haloredivivus sp. (strain G17)|TrEMBL
MLYMVGLGLDNDEITQKGLEALKKVDEAYAEFYTNTANIDLEELPGEIEVLEREEVEQED
RILEAAEEKDIAFLVSGDPLTATTHYDIKHRAEEKGLEVKVVHAPSIFTSIAETGLNVYK
FGRTVTLPREGEPESIRKYVEKNDSVCLHSLVLLDIDFDASEAAKKLLNLGLEDREALVV
ERGNHDDMSITLTSLKEASESSFGATPHSVILTREKSFKEEEFVEKYG
>A0A7L4R062|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLDFVGLGLFDEKDISLKGLERIHNADKVYVEFYTSILMGTDLEKMEDLYQKKITVLSRE
DVEQHAEEWIADAKDMNVVFLTGGDTMVSTTHVDLRLRALDMGIETSLVHGASIASAICG
LSGLQNYRFGKAATVPHPYVTSRGSRVISETPYDTIKMNMENGLHTAVFLDIDKDKGYMT
VNEALEILLEVEGKRGEGVMKDRISV
>A0A062V110|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedens nitroreducens|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVRRADIVYAEFYTSHLMGTSIEKMEELYGRKVTVLTRE
DVEQNTSWLSLAKEKNVVFLTGGDAMVATTHIDLRLRAIDMGIDTAIIHAPSISSAVSGL
SGLQNYRFGKSTTIPFPYTRRDKTIISEAPYDTIKMNRRNNLHTLVFLDIDREKGFMRIG
EAVSILMEMEERRGEGVLVNALAVGIARAGSDSPVAHADYLEKLKDYDFGRPLHTLIIPA
QLHFIEAEALVKLCGAPQDIMK
>A0A811T843|diphthine synthase|EC 2.1.1.98|Candidatus Argoarchaeum ethanivorans|TrEMBL
MLTFVGLGLYDEKDVSLRGLEAIRSADKVYLECYTSLFTGTNIKQLEKLYCKKVHLLERE
DVETNNWWLKDAIDQKIVFLTGGDAMVSTTHIDLRLRAKKLGIGTQIIHGASIISAVCGL
SGLQNYRFGKSATIPHPYTRKEKIIRSHTPYDTIELNQKNNLHTLIFLDIDKNIGCMSIK
EGIELLLQVEEEAGGEAISNCIGVGIARAGSFAPVVKADYLENLKHIDFGDPLHILCITA
NLHFIEAEALVAFADAPGNILNHHKDSLCQDSVSENHAH
>A0A5N5UKC0|diphthine synthase|EC 2.1.1.98|Halosegnis rubeus|TrEMBL
MLTFVGLGLWDEDSITVDGQRALRAADEVFAEFYTSRLMGTDPESLATHHGVDIDVRDRA
GTEQEPEPILDAAESGDAVFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGTTASAAAAS
LTGLQNYRFGKATTLPFPYAHGGDGVPNSVCDTLDANRERGLHTLVYLDIKQERGEYMTG
DVAADLLTDGYEDVLGVVVCRAGSPEPRVEAGLLSDLATREFGDPLHLLIVPGELHYIES
DALRELAGAPEELSEPV
>A0A662TDH6|diphthine synthase|EC 2.1.1.98|Candidatus Geothermarchaeota archaeon|TrEMBL
MVILTLYIIGLGIREETELTEKLISILRRCKYVYWENYTSPATYNLSDIIRILEREVRVL
RREDLEGRIEDIIVDAKKENVAILVCGDPLIATTHVNIILEAKRMGIEYRVFHASSILSA
GIGESGLHLYKFGPSGTIVREEKVSNKRNIDILKFNLENGLHTLYFLEYDKDEEYIMPPS
YAIKILSKYAGNILSNYNPYIIILCGIGTQNPYKRALKYNEVIKLLNKLPVDKPCIIIVS
GQLHYMEKEYIEKVLR
>A0A3A5UUJ6|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MALALSKRARGLSMAEDTVVLPNLPDTGLLLIGMGPGTVTGMTLEAIQAAKKATHRRYEA
YTALWPESELDLLEQQIGNIQRVMRPEVEQPDELFALAKNSLVALLVVGDPLQATTHVDL
QLQAMEHEIECRVFHGVSITTIVTGAVGLSNYRFGRQTTLTYPYGGWIATSPLEVVAVNR
FRGLHTLVLLDLDPTGQGTGDQRPMRPVDAKKSMELMWDKLSEQQLESSEIQDKDMMNAA
FKSLLDGEMEEFPVVLCADMGTEDQEIIFTTVGGLEHLNGGRLNCLLVPARTSEVEEKAL
LRWKQDK
>A0A6V8CZW8|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MDSSGLFLIGLGPGDLALMTRRAIDMLQDMDERYLEGYTATLPLAQENELENIVGPWKRA
MRPQIENPREIIEMAKSQKVAIMVVGDPMQATTHVDLLLRARENGVQVTIVPGISATTLA
ISSSGLQSYRFGRQVTLPYAYGDYLPTSPLRYILDNRLRNLHTLVLLDLDPTGLGIESPI
HMSPSVAGQILMQMAERWSEENEDVDVCAWNVVVLSDLGTDQSHVCSTVIKEMNGMDGGR
IHCLILPAEMDNHEQMVFDSMRYHA
>A0A2G1WU45|diphthine synthase|EC 2.1.1.98|Halorubrum sp. C191|TrEMBL
MLTFIGLGLCDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A831P603|diphthine synthase|EC 2.1.1.98|Candidatus Nanopusillus sp|TrEMBL
MFILSGLGQNKDEIPYGLIEEIKSADLIFLEYYTNFIDEETKEFLLNIRKDIRIVDRNFV
ESDLEKIILNNKNKKIILITSGNPLFATTHMYFIELCKKNNIEFKIINSPSIFDEIGKIG
LFLYKFGRTVSISFHESTEFYDYIIRNYKNNLHTLVLLDLDPINNRYLDHKEAIKRLLEI
DSKREKIFNENFKLIVCSNLNRKNEKIYYKEIKELLNINLDPPVCIIIPSNLNKIELEFL
LCMIS
>A0A0K1DZB2|diphthine synthase|EC 2.1.1.98|Pyrobaculum sp. WP30|TrEMBL
MLYIVGLGPGPGYATEAALRAIREADCVFYEDYTGPLDLETLRRAAVGEPVRLARRDLEE
ESGRRIFECLREGRRAVLVTAGDPALATSHHALVALARARGFPVQIIPGVSIICAAFSAA
CLSIYKLGGVATVTYPRGGIYSRRPYELAEQNLRRDMHTLLLLDVREDGFFMPPRDAAEI
LLRLEEEEQRGVFTLDRHVAVVYRLGWGGSTLYTQLRDLLSLEAEGPAVIIVPARLSPVE
KECLEVAAARRPAGKAP
>A0A5P9NZN1|diphthine synthase|EC 2.1.1.98|Natronorubrum aibiense|TrEMBL
MLTFIGLGLYDERSITVEGQEALRDADRVYAEFYTSKLIGTTVADLESHHDVDIEVRDRA
GVEQHPDDILDAAETEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTRTIDDNREDGLHTVVYLDIKVDNEAATNR
LEGDETIEEYMTADVAAALLAEEYPDLVGVVVARAGSPDPLVDADTMAALADREFGDPLH
LLVIPGDCHLLEADALVELAGVDRADLDVV
>A0A3R7D123|diphthine synthase|EC 2.1.1.98|ANME-2 cluster archaeon|TrEMBL
MLTFVGLGLYDEEDITLKGIAAIRDADLVFAEFYTSWMMGTTIERMESRYQKKITTLSRD
DIETDPSWLHHAIKSDVVLLSGGDPMISTTHIDLRLRASDLGIATAIIHGTSIVSAASGL
SGLQNYRFGRSATIPFPYRVRSKTIVSETPYNVILSNRDADLHTLLFLDIDSEQGFMTIP
QAVQLLMQVDEKRLLKGVLGVGIARAGSRDVVVRCDYLYDLAGFDFGAPMHLLIVPAGLH
QMEAEALIRFAGAPEEVRNSGR
>A0A257A985|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon ex4484_217_1|TrEMBL
MPWLAFVGLGLKLKHLTLEAIEVLKESDIIFLDSYTSVGEDISAETLSSFLKKQVIPVSR
RNIEDENGKIIFDALDKGLNVSFAVIGDPFIATTHIALLLYAVRKGIRIKIVHGISIYSV
AISCSGLMSYKFGKSATIVYPKEGITYEYFYDVIKENKRRGLHTLLLLDLDAEKGIFMGA
NEALKLLMEIERKRKERVILENEKVLVIARASLRNQKCIYGAISELVSKDFGPPPHAIIV
PGKLHFIEEEALRRFMIK
>A0A843MGT2|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFLKSYIMFYLVGLGLFDAGDISLKGLECLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A843ISD1|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFEAIEELIGQKIEVLVRG
EVEEEHKFIEEAKTSDVALITGGDPLIATTHSDFLVQCSKKGIDFEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEAIEENLKMDLHTLVLLDIQAHKDRYMTVNQGL
EYLMNIKNDLDREGLITEDTLAMGIARVGSKDVVVRAGKISELIDFDFGGPLHCIVIPSK
LHIVEAEYLVEIAGADKSILDDV
>U1N8K3|diphthine synthase|EC 2.1.1.98|Haloquadratum sp. J07HQX50|TrEMBL
MLSFVGLGLYDTESITLQGKRAIEEADHVFAEFYTSRLLDANADILEQFYEITIDICGRA
EVEQDPTAILDAAETGEAAFLTAGDTMISTTHTDLRLRAMERGIETRIIHGVTAQTAASG
LTGLQNYRFGKSVTLPFPESHGTTGVPPSVCDSIDANRSRGLHTLVYLDIKAAQNKYMTA
TTAATLLADSIEDTLGVVVARAGSPSPTVAAERLSTLASIEFGDPLHLVVIPASLHHLEA
DALSALTNASSQLIDDYRE
>T1BGU5|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
AHLAGEPRTLVFFEAPHRIAAMLADLAAALGPERRAAVARELTKNA
>A0A838VZS8|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLCLIGVGINEYDSLSSSSVEMLKNSDMIYVERFTGFLSNGFIEKIKDLVNGYGFSSKKK
SIEVQLAKRWFVEDGRQILENSLKENVSILIYGDPLIATTYNELLVRAKKQSIPYKVIHS
SSGIPSLVGESGLHYYKFGKMVTIMSDPMSSITVYDTIYNNMCYGLHTLILTEYNNDLES
DGLSPTKNPCPFFLSPKRVFDLLMEREYELKLLNWSEDSFVIVTCKIGTESSKVICGKIK
SLMNIEFESGPNSIIVPGNLHFTEVDSIKNLTIALDDPDDNSAKVNKLSSRMLDKYIPNA
KKALSTLSSLVKEKENDFKEEYSVVLENAENYLFDAENFYRQGRIELAILSVGYAEGLID
SIRFQKGMNPW
>A0A2H9LM70|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon CG07_land_8_20_14_0_80_47_9|TrEMBL
MGQIVFVGLGLHDDLGISLRGMEETRTAKHVFIELYTSLLPAFSKKRLEKAAGKELREVS
RKELEEENGKVILDAAKDGKVVLLVPGDPLIATTHVALRIEAEKRSIRTQIVHGSSVLSA
VIGLSGLHNYKFGKSVTIPFPDETPSQTPYEVLTQNKKLGLHTLCLLDIKAELKRYLSIR
EALACLLEIEKKRKKETVTPETLAVGISRAGSSNPMVKAGYVRDLISFDFGGPPHSIIFP
GKLHFMEAEALIVLAGAPERIRRMAE
>A0A842MIG0|diphthine synthase|EC 2.1.1.98|Candidatus Methanosuratincola sp|TrEMBL
MPSLAFIGLGLYDERGISLHGLEIAKSADIVLLENYTNVMPGLDLESLGRMIGKEIRLVG
RSEVEDGRWILDAAAHREVVLLVAGDPFVATTHVDLRLRAIKRGIRVEVVNAPSIISVAP
GAAGLQNYKFGRSATITFPEPLSLVPYETLKINRSLGLHTLFFLDLRVEEGRFMKAGEAI
RLLLEMEAQQRGGVVSGDTLMVVLARAGSPSQLVRAGKASVLKDLDFGPPPHSLIVPGRL
HFMEAEALVLIGGAEEGLVRGCL
>A0A7C1CCA9|diphthine synthase|EC 2.1.1.98|Thermofilum adornatum|TrEMBL
MLVIAGIGLFDLRDIPLGLLEEVKDASAVFIETYTSILPGFSVDKLSRLLNRQIIQLVRA
EIEDKGAKIILEKAKNEKVILLVVGNPLLATTHASIIIDAYRLGITVKVIPAASVIDGLI
VSTGLHAYKLGKIVTLVFPEDKELKNYPYTPYQTLSDNLSRGLHTIFLLDIRQEERRYLL
APEAASLLLKIEEKFKENVLDDDTLAIAVARATADNEQVYVGKLSDLATRDLGGPPHTLV
IPGLLHDSEIEFLYYKTGTPIGVFKDWNKKLSARIMQRNT
>A0A1H2YUH5|diphthine synthase|EC 2.1.1.98|Haloarcula vallismortis|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIQDADRVFAEFYTSRLVGTDLETLEASLGTTIEVRDRA
GIEQNPEPILAAAESEDVVFCTAGDTMVSTTHTDLRLRAEDRGIQTRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRARDLHTLVYLDIKVDDPHWDES
DDTYMTASHAAELLSKPFPDTLGVVVARAGSPDPLVVADTLDDLAEQTFGEPLHLLVIPG
SLHPLEADVLESTAGADLE
>A0A1V0N2D6|diphthine synthase|EC 2.1.1.98|Ferroplasma acidiphilum|TrEMBL
MLNIMGLGLRGTKSLTLEEADALKESDLVYFEIYTSISPGNTVDSLSSLTGGMIRLADRN
LIETDSEIINEAKNKIVTLLVTGDALSATTHNELRMEAQKAGVEVRIFENASIITAFISK
TGLFNYKFGNIVSMPFIYENFFPVSVYDRIYINYSNNMHTLLLLDLKDGKTMGIQDALGI
LKRMEDSRKKGLIEPERIVIAGIAIGSENESIIYGNLDKVMEYNPPGSPASIIIPATIND
NEREFLEAFARKIN
>A0A2R6CTM4|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_2_65_14|TrEMBL
MLSFIGLGLYDERSITLQGRDALRDADRAFAEFYTSRLVGTTVDALEETHGIDIEVRDRA
GVERDPEPILDAASGGHAAFLTAGDTMISTTHVDLRTRADERGIETRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFEETRGGVPDSVLATIGENRERDLHTLVYLDIDAESERYMTGDT
AAGLLADHLDAVGVVVGQAGSDDPTVRADRLGALAGESFGPPLHLLVIPGDLHPLERESL
RTFGGAPADALE
>A0A8D6PY92|diphthine synthase|EC 2.1.1.98|Methanocaldococcus sp. SG1|TrEMBL
MIVFAGLGLYDENDMTLKTLKFAKKVDKIYAEFYTSVLTGTTIEKIEEVLGKKIIVLSRK
DVEYDGYKIIEEAKDKDIMFLTAGDPMVATTHIDLAIEAKKRGVEVLIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIEENEKRFMTANE
GLKILLELENRKKENVLSEETKVVVVARLGSLKPKLVYGKIKDLINYDFGKPLHSIIIPG
KLHFMEEEALKYLCENI
>A0A2R6CY05|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_10_67_22|TrEMBL
MLTFVGLGLYDERSITVAGRDAVGEADRVVAEFYTSTLAGATVADLEAYHGVDVEVRDRA
GVEQSPGDVLDDAEGRDVVFLTAGDTMVSTTHVDLRLRAHERGIETRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFGRSHGGEGVPGSVTDTIDANRERGLHTLVFLDIDAANDAYMRA
DEAAELLADAWRDDLAVAVARAGSPDPVVRADALSTLAGESFGDPLHLLVVPGDLHHVER
DALVELAGAPRSLVGE
>A0A497J9X9|diphthine synthase|EC 2.1.1.98|Candidatus Hydrothermarchaeota archaeon|TrEMBL
MLVFIGLGLNSERDITLRGIEEAKSSDLVFAEFYTSKMPELNLKNLEKIIGKEIIVLSRK
EVEEEGVKILEKAKNKKVALLVAGDPLISTTHVYLRIEAKKLGIETKIVHNASIISAAPS
ISGLQNYKFGRSTSLVFPEKNFFPTTPYDVIKENKARGLHTLVFLDIKENKLMTANQGMK
LLLEIEKKRRENVFTEDTKIVVLARVGSDSLSMRFGRVEELLNQDFGEPPHTLIIPGELH
FMEEEYLARFG
>A0A848EM24|diphthine synthase|EC 2.1.1.98|Nanohaloarchaea archaeon|TrEMBL
MVLIRVCLNLSSWTFVFMLRIVGVGLDDGEVTQKGLEAIERSEKVFAEFYTNTETVDLEL
LEEETGQDIQKLSREEVEQRDRILESAESSDTAFLVSGDPLTATTHYDIKHRAEESDLEV
EVVHAPSILTSVAETGLNVYKFGRVVTLPENMKPDSVVEHIEKNDSVGLHTLILLDIDYS
ADEAAEKLIEMDETLSDRDAVLVERANMEDQSISYGKLSSLDPEGETPHSIVLVGDTSHK
EENFIRD
>A0A848EPH1|diphthine synthase|EC 2.1.1.98|Nanohaloarchaea archaeon|TrEMBL
MVLIRVCLNLSSWTFVFMLRIVGVGLDDGEVTQKGLDAIERSEKVFAEFYTNTETVDIEL
LEDKTDQDIQKLSREEVEQRDRILESAKPSDTAFLVSGDPLTATTHFDIKHRAEESGLEV
EVVHAPSILTSVAETGLNVYKFGRVVTLPENMKPDSVVEHIEKNDSVGLHTLILLDIDYS
ADEAAQKLIEMDESLSDRNAILVERANMEDQSISYGNLSSLDPEGGTPHSIVLVGDTSHK
EENFIRDRG
>M0LP94|diphthine synthase|EC 2.1.1.98|Halobiforma nitratireducens JCM 10879|TrEMBL
MLTFIGLGLYDERSITVEGREALRNADRVYAEFYTSTLIGTTIEDLEAHHDCEIEVRDRA
GVEQEPDEMLEAAENEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGITAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPSSVTETLEANRADGLHTVVYLDIKVGHELTDDD
EYMTADIGAELLAEEYPELVGVVVARAGSPDPRIEAGTMTELAGREFGNPLHLLVVPGDC
HPLEADALVELAGADRTALEVA
>A0A843CKS3|diphthine synthase|EC 2.1.1.98|Methanosarcinaceae archaeon|TrEMBL
MLTFVGLGLFDETDVSLKGLKAIQEADIVYLEFYTSRLMGTTIEKMEALYGKKINLLVRE
DVEQHPDWLENAKDRNVVFLTGGDTMASTTHVDLRLRADKMGIPTKLIHGASITSAVYGL
SGLQNYRFGKSVSVPFPYISARGNKVITETPYDTIRQNQERGLHTLVFLDIDKDKGYMTV
KEALSLLLSVEEKRGEGVMKHAVAVGIARAGSDSVLVKADFAENTESFDLGEPLQILIIP
GKLHFLEASALVHLAGGPEELLEIADE
>A0A662P3V5|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MALYFIGLGLYDEKDITLKGLEIARKCDYVFAEFYTSLMAGTTLERVQELIGKKIKVLSR
EDVEMNFERIVLPLAKDYDVAFLIPGDPMVATTHSELRIRAKRMG
>A0A3G9D1R5|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp. MT-2|TrEMBL
MLYIIGLGLYDEDDISIKGMKALKKCERIFAEFYTAKLKNQSLSSIKKELGKEIKVLGRK
EIEEKMIPLKNAQKWNVAFLVPGDPLVATTHSNLILEAKKNNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEKNYFPHSPYLTIKDNMKYNAHSLILLDIKADENRYMSANEGL
EYLLKIEKERQENIICEDSLAVVVARAGSQDPLVRADRIKTLIGEDFGKPLHCIIIPSKL
HFLEAEYLTKIGGAPPEIMEEENETP
>A0A3M6K3X2|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosomarinus sp|TrEMBL
MLSFVGLGISGFESIPIEGLETISNADVVYLEQFTSPISETDLEKIKNSTKGEFKLAKRW
LVEDGNEILEISKEKNVVLLAYGDPYIATTHIELRARAIENKIQTNSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNLIEGNHTVLLLEYNQDKNFFLDPKDALIG
LLKTEQGQSRKVITESNYVIIASRIGFKDQAIVSGEISNLKEMDFGKPPHTIIIPGRLHF
TESDALKLFGKCIDEPFDNSEKTEKISNQMMKKYVPMVREALEEVEPYYKDQKEFEVILD
NAERYIKDAEIFLGEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A7C5EAR8|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
SVIPGLSAEELERLTGKKVKVVDRKTVEEDPEEILEAARRGRVVFLVPGDPMVATTHVDL
RLRAHRAGIQTEIVHAGSILSAAAGMCGLQSYKFGPTATVPFPDNPSSRPYDVLAENKGR
GLHTLLLLDLRAEEGRAMTANEAMRIMLALEEKHRRGVFTLRTPVIVIARGGGKDQLVRG
GRVGDLIGLDFGGPPHCMVVPGRLHFIEAEALAVFTGMPEDAVDELR
>A0A4U7DYK7|diphthine synthase|EC 2.1.1.98|Halorubrum sp. ASP1|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLIGADVADLEAYHDVDIAVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETVEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADAAAELLAEGWADELAVAVARAGSPDAVVAADRLSALADRQFGDPLHLLVI
PGDLHHVEADALVGLADAPDALVEE
>A0A4U7DGG0|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SP3|TrEMBL
MLTFIGLGLYDERSVTVEGRAALREADRVFAEFYTSRLVGADVSALEAHHGVDIEVRDRA
GVERDPEPIFEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDGVPASVVETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLAEEWGDALGVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVGE
>A0A7C4G751|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGGKLYIVGAGLSSDLITLRGIKTLKNSDIIFMDSYTSMLCNSDLEDIIGRRIYKLRRVD
LEERFEEVLFKPVLQGLNVSLIVPGNPLDATTHVSLIVEAYRRNIMFEIIPAPGIIPNAL
SMSGLMVYKIGKVTTLTYPKQGFLSDYPYDVIKDNDLRNLHTILLLEVDLENNIVMSISD
AVDILLKLEEKRGEKIVNEERKAVAISGLGGSNQRICFNSLKKLKTLPKHRGPHTLVLTS
PKLHFMEEEGLKALSTFNINAN
>A0A537H4V7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVRTPNPRLSLLALNNTSPAKKRPFRKQAHSSVVMSVTFVGLGLNDEKGLTVEGLEEARK
ADAVFAEFYTNIMPGLDVEKLEFLLGKKIVVLDRAQLEDENGRQILEATGRGKVAFLVPG
DPMIATTHVSIMLELARKGIQSRIVHGPSIASAVCGATGLQSYKFGKTVTMPQESGVPGS
LVEGMMDNRKRGLHSLVLLDVRSDRSKQLTVGEAAAKLVAADPLFESWLGVGVARVGSRD
QFVLAGRLGRLQREDFGKIP
>A0A497LQ45|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MRRGLKLISIGLADEYDLSLRAMEEARSCDKLYVELYTTKLSTSKERLEAILGRPLREAY
RRDLEGERPRILEEASQSLIGLLIGGDCLTATTHISLLLEARRRGLPTWVIHGSSILTAI
AETGLSLYKFGKVVTLPLPERGPPDTVLEALEGNLSLGLHTLILLDLDAERGRWLSIGEG
IRLLLNADRPDIFNDETPLIGVARLGWRNPLIRGGRASELLNIDFGEPPQALIVPGRLHF
VEEEGLRLLANLPGEALKGWRPRSETELLVERYMKSCRRVMEKLESSPLREEAQRILDYA
SRYLSDAEYYANEGRWPTALAAVSYCEGLLDALRLLGLAEFEW
>A0A497MG45|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MFLHPPPYWGYGLGELVFVGLGLRGLGGLTLEGLERARKADKVFLELYTSPISDFSLEDL
RRLLGKPPILLRRADLEEEAGRRVLEAAEKGCAVLMVPGDPLIATTHIDLRLRALKAGIR
VEVVHAASIYSAAPSIAGLQIYKFGKTVSIPFPRPNYMPETPYQVLGENLSRGLHTLLLL
DYDAEEGRWMTVREGLQYLQTLEERLGGGVATPERLVVGLAGVGGGDVEIRGGSLRRMLE
AEFRLKPQTIIVPGSLHFVEAEALRVLAGVREEEIR
>A0A524NL79|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MNELVFIGLGLNDEKGITVKGLEETQTADQVFMELYTNLMHDFSLQRFEALCGKKVQIVS
RKILEEENGKVIIEAAQVGKAVFLVPGDPFIATTHVTLRIDAEKRGVKTRIIHGTSIMSV
IISLSGLHNYKFGKT
>A0A7J3C9W8|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MIGFISSGLNPPESLTIEETEFLEKCTTIVVDTYTSPNFMKQYKDRNLVFVTREKMENFE
WILDQKGNVGIVIPGESFSATTHFIIYREALKRGLEVRIFHNASVFPTAATAMGLHLYKV
GPAISLPRFTENFKPLSPYEKILDNRRRGLHTILLLDTDPPLSLGDALVELQFMENSAGM
NLFRDESEIGVVSCLGMPEERIIFGTIKKIREAKSPTPPITIIVPGELHFQEREAVELFR
E
>A0A3M1H9Z9|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MHSRAMLYLIGAGVSIDLTSRGLEYCKEADEIYLDRYTVLVEGAKEKLEKQIGKEVKEAG
REFLESKEPLEIAKDKDIAIISIGDPFFATTHISLYVQAKERGVGVKVAHNSSIVNIVGR
TGLSPYKLGGTVTIARWLENYKPSSPIERIGNNIKAGLHTLVLADISNGENMGIEEFVRT
ARAMEEKEGSKVFKRVICVSRAGLDNEKILYVEFDELPSLAIESPYSILVPAELSSYEKE
NLEKLY
>A0A534HX52|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MRGKGSSPAVGSRFSMGELVFIGLGLHDERGITLHGLEEARSADVVFAELYTSGLAGASL
DSVERLLGKKVQKLSRAELEGGEVVLKAAAHQKVALCVVGDPMAATTHVDLRLRAVSAKI
PTRIVHGVSILTAAAGCLGLQAYKFGRTTTVPFPAPGFEPTSPLEAILANRRAGLHTLVL
FDLREDGTFLSPTEAIASLLRMGTAMRTKEFGPDTLACVLSQVGAPDVRVVADRMGSLRK
RDWGPPPHCLVVPGPLHFLEKEALVAFAGAPHDL
>A0A1N7FTQ1|diphthine synthase|EC 2.1.1.98|Natronorubrum thiooxidans|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSKLIGTTVDDLESHHDVDIEVRDRA
GVEQHPDDILAAAETEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPESVTRTIDDNREDGLHTVVYLDIKVDNEAATNR
LEDDETLEEYMTANVGAELLAEEYPDLVGVVVARAGSPDPLVEADTMAALADREFGDPLH
LLVIPGDCHLLEADALVELAGANRDDLDVV
>A0A522EQL3|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MALHIIGIGLGDENGLTLSQIDTLKKCSKVFLEDYTNVVHINEKNFEKITGKKIKKVGRD
FVEDSEKLVSSAKNEEIALLVSGDPLSATTHIEFLLDGKKQNIEVKVYSNASALTAVGLA
GLSLYKFGATASVPNPEENFKPESFYEIFEKNQRVGLHTLFLIDPNEKNGKKLSLKEALE
WLKKIDSKKKKLITSKTKIIACSNLGREKQKIQVGSFEEIKKQELEHPICFIIPGELNFK
EEEALKIYS
>A0A523ACD1|diphthine synthase|EC 2.1.1.98|Archaeoglobi archaeon|TrEMBL
MLTLVGLGLQDFRDITLRGYEAVKKAEEVYLDTYTSRISSSIEDLQRFFGKKIIEAKRSD
LEEGGRKIIERARERDVVILIPGDPTIATTHIALVLEARKANVETRIINNASIINAVCSL
TGLQNYRFGKSATISWFRSRAFIDTIYANLSIDAHTLLFLDLNPPMTIKEAVSRILELDS
GFKDHFAVGVARAGSEDAVVKCDRLKELAYFSFGEPLHSLVILSKKLHVL
>A0A842XK89|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MLTFVGLGLYDEKDITVKGLEAIRAADVVYAEFYTSPLGGKRVEQMEEVFGRKIVLLQRS
DIEEHAEEVVLAPAKNQNVVLLSGGDAMIATTHLDLRLRAIDRGIETRIIHAPSISSAVA
GVCGLQNYKFGKSATVSPPYKGVISEVPYETIRANKERGLHTLLYLDISMRISEAVGLLE
AVEEKKGGAVLKKSLLVGIARAGSAKPVVKADYLNRLKNYEFGELPHVLVVPGELHFVER
EALIKIAQAPEEI
>A0A0F8NAP6|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 1.H.A.2.2|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRGESVMDRAVAVGIARAGSEKPVVKADYAENLKDFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMEETE
>A0A498L6Y9|diphthine synthase|EC 2.1.1.98|Halorientalis pallida|TrEMBL
MLTFVGLGLYDERSITVAGREHLRAADRAFAEFYTAKLVGTSIGDLEAHHGVDIEVRERT
GVEQDPGPILDAAADGDAVFLTAGDPMISTTHVDLRLRAHDRGIDTRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFERAHGGTGVPDSVVETVTDNADRGLHTLVYLDIKAADDDYMTA
DVAADLLAAEYDQRLAVAVCQAGSSDPSVVADDLPVLADRDFGPPLHLLVLPGDLHLLER
DALVELAGAPETLVANRTI
>A0A7G2D9L3|diphthine synthase|EC 2.1.1.98|Thermococcus camini|TrEMBL
MAIYFIGLGLYDERDITLKGLETARKCDLIFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EEVELHFERIVLSEAKERDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMIREDFGKQPHVMVVPG
RLHVVEAEYLVAFAGAPKEILDGI
>A0A1V4UCP6|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon PtaB.Bin009|TrEMBL
MLTFIGLGLHDHKDVSMRGLECIREADHVFLEGYTSRLSGTSVSEMQAYFRRPIRVLGRE
DVEQHPEIVLDPAATGNVAFLTGGDPMVSTTHADLRIRAALRGIRTALIHGASISSAVCG
LTGLQNYRFGKSCSLPFPAKNWSPATPIEVIGKNLSQGLHTLVYLDIQEERCMTIPEAIV
LLEGLAEKAKVSIPLYVGVARAGSGAPVVFAGTAEKVTQADFGPPLHILVVPGPLHVVEE
EYLTMFGGL
>A0A3N0A674|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp. B06|TrEMBL
MLWFMGLGVSGFDSISVRGAELLARADAIYLEQFTSPVPKDDISRIKEIAGGKLILAKRW
QVEDGKEILDSAKNGETVLLSYGDPYIATTHIELRSRAITQGITTSTIHAPSALTAIVGE
CGLHFYKVGRVATIMGGESFSTPYYTTYKNMVQGGHTILLLEYDQEREFFLDPKDALTGL
LEAEKGQARNVIGQSTYCIIASRIGSADQKITAGMISSIVKTDFGGPPHTVIIPGSLHFT
ESDALDASCVCIDSPTGNTVEKISAQMIAKYVPMVREALNEARTTHAGRHDEILENAELY
IRDAEKFLADGQDEVAVLSIGYADGLIDALRMADGLEPKM
>A0A7J3DM86|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MFYLISVGLSIRQITLEAFDTMRKCDELYFDTYTSIYANTLQKLEQIAGKNIVPLGRLEI
EGLFFEKLKAAKEKNIGLIVVGNALFATTHIQLLIDCAELGVPYKFIPGVSLTSYLGLTG
LSTYRFGETVSIVIPEEHYSPKSFYEKIARNYKNNLHSLCLLDIKDGKPVTVASALSRLL
EIEKRRKRKLIKDATIIVICKAGTDEEIVIAGKASELAEKNLGTPASLIICAELSENERR
AIKALYMQKV
>A0A7T5RSB0|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MARLTFVGLGLGPRGISLEGVEELRTADVVYLEYYTTPHEPTLLRELQSATGAKITVVDR
DFVEDGRRILEEAGTKKVALAVLGDPMIATTHDDLRTRAIRAGVETTVVHSASIASAAAS
ASGLHYYKFSRTTTVTRESVNKLSQVYHLLHQNLLEGAHTLLLLEYDQQSGEGVSPADAV
AGLLLAEANFKRGVVTEETFGLVESRLGRENSAMAGGSFAELGRKEFGDSPHSLVVPGKL
HFTEVESVSAIFSLAPESVRGNSDSVLRTAQSLVPKYVEKTRKALSGAASKLGPSYSAVL
ENAELYLRDAERNLAEGEDEIAMLNVGYAEGLLDALGFAGLVKVEW
>A0A497IBT5|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
MLSLIGMGLWTIGDLPLRAAWELRKCDEVYAEQYTNAMQEGILSQLQSKLGKAQIKVLGR
AEVEKGKVLLKAAEKKRVALLIPGDPLVATTHVSLLLEAKKRGIKTQVIHASSIYTAAAG
EAGLQIYKFGKSVTLAKWHAGYEPMSAYSAVEANLKQGLHTLLLVDVDEGRPLSQAEIFD
LLKK
>A0A662I9I2|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLVIVGLGLYDLRDLSLGAFDTLRRASKVFVELYTSIVPGFKLEELEKLLGRQVEVVHRH
QLEGKWLDELMETAKREDVALVVPGDPFIATTHITIKLEAIKRGIKVAVYPAPSIINAVI
ASTGLQIYKFGRPVTIVRQTPLYSPVTPYYVLYENLRRGLHTLFFLDLNVEEGYAMTAVE
GVEVLRSIEEREGLGLIDEYTPFIAVARASSPDEVVRVIRLSEKADLGPAPHTLIVPGLL
NPVELEALSLLAGASTDLLSRWHERVRDLAASEA
>A0A7C0TYY0|diphthine synthase|EC 2.1.1.98|Thermococcus litoralis|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTDIGKIEEQIGKSIRLLNR
EDVELNFERIVLSEAKTKDVAFLTAGDPMVATTHADLRIRAKQMGIKSYIIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKENKERGLHTLLFLDIKADQRKYMTANE
AMEILLQVEEKKKKEVFTEDTLVVVLARAGSLNPTIKAGYVKDMIKEDFGKQPHVLIVPG
RLHVVEAEYLVAFADAPEQILKEV
>A0A166EMC4|diphthine synthase|EC 2.1.1.98|Methanobrevibacter cuticularis|TrEMBL
MLYFVGLGLFDLKDISLKGLDVLKNVDVVYAEFFTSRLFGSNFQAIEELIGNEIIILNRE
EVEEENVFLKDALNKNVALICGGDPLIATTHTDFLLEAKKMGIETKVIHGSSILSAAPGI
SGLQAYKFGKVTTIPFPDHNFFPHSPYLAIADNLINDAHTLVLLDIQYHKDRYMTINQGL
EYLLEVRDDLIAKNKEVVIDEKTLAIGIARVGSYDVIVKAGSIEELIEYDFGGPLHCIVI
PSKLHIVEAEYLVEIANGPKHILDNV
>A0A1Q7ZSU8|diphthine synthase|EC 2.1.1.98|archaeon 13_1_20CM_2_51_12|TrEMBL
MSLTFIGLGLNDEKGITLEGLEEARRADSAYGEFYTNVMPNLDLKNLEKEIGKKIEVLSR
GHLENEGGKKLLRAATKERVAFLVPGDPLIATTHISLRLSAVRMGIESRVVHAPSIVSAA
SGATGLQSYKFGKSITIPRDQPLPKSVLDTISDNFDRGLHTLVLLDVQAGKTSQMTIRDA
VIKMTTADGRLETRLAVGVARLGSRDEKVRAAKMKALMEEDFGEAPHSIIVVGGLHFMEA
EALELLCGASPEDLRELT
>A0A7K4BYH9|diphthine synthase|EC 2.1.1.98|Candidatus Methanofastidiosa archaeon|TrEMBL
MLYLIGLGLSERDLSLKAFELLKKIVNIYVDTYTNYFDFDLLWLEKELNKKIVPLSRNDM
EKNPSFLDIAKSEEVAILVSGDPLVATTHTDIILRANKMGVKTKIYHASSIYSAIAETGL
HIYRFGKTASIPYPEENFFPKSFYDVIIQNKERNLHTMLLLDVKKEENLFMNPKEAIDIL
KEVDKNRNIKDIIVISRISYENQKIIYGDIDELIKIENKYYGLPPHTLVVPAELHFAEEE
YLFSLAEIYKNSKNK
>A0A7J3D360|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MLALVGLGVNGIGSISLSGNMTLRKSDIVYLDGYTTPIPQNLVEKLCRQIGKQVIVLDRT
GLEQGLGRIIDEAKTNLVSVAVLGDPFFATTHLNFLIEAKKNNLSCKVIHNTSIASILTN
SCGLHPYKFGRVTTIVREHGTPATSAYFALYDNLIRGVHTTFLLEFDVENNVGVSPLNAF
NLLKDAEETYKLGAFSDETFVIVACRVEREDERFFAQKVGGLWKTDFGSPPYSIIVPSTL
HFTEKEAICALYGIDESVITDNTQNIKRRTDFLVRKYIRKTRETLCEARGKLTKEKLREL
DDLFENVECYLDDSTRFLNLGEEGLAMLSVGYAEGLLDSLRFQRVLDLRW
>C9RHT0|diphthine synthase|EC 2.1.1.98|Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)|TrEMBL
MLILAGLGLYDENDITLKALKFAREADVVYAEFYTAVLTGTTIERIEEVIGRRINLLGRK
DVEYEGYKIIEEAKTKNVVFLTAGDPMVATTHVDLAVEAKKKGVDVKIINAPSIYSAVGI
TGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIKIEDDKKRFMTANE
ALEILLKLEERKGFGIISEDTWVVVVARAGSLNPKLVYGQIGNLINYDFGKPLHCVIVPG
KLHFMEEEALNVLCEKI
>A0A2A2H4A4|diphthine synthase|EC 2.1.1.98|Methanobacterium bryantii|TrEMBL
MLYFIGLGLYDEKDISLKGIEALRKADVVYAEFYTANLFGTTLDALKFMIGKDIVVLKRS
EVEEENIILESAKDKNVGFLTAGDPLIATTHTDLMIEAKKRNIETTVIHASSILSAAPGL
AGLQAYKFGKVTTVPFPDKNFFPHSPYTAIKANIEFNAHTLVLLDIRADENRYMTVNEGL
EYLLKVEEERKEGAITEDTIAVGIARAGSDKPFVRADKIKNLIKEDFGGPLHCMIIPGDL
HFMEAEYLVKICGAPEEILEDQ
>A0A7J2K6I1|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MPIHLIGLGLGTIQYLTLGALETAERMDELFIDTYTSWIDQDLVRYLEERFGEKLVKADR
SMLEERIGELIERAEEKEIGILVPGDPLIATTHISIILEARRRNIPAHLIHGVSIISASA
SASGLQAYKFGRITTIPKNGVGIETCYRFVAENLEKGLHSLILLDTADGGLRIPEALRML
MKVEDELGYGIFHPSNLVICLTRIGSGEEFRWAGKISDAIEIDYPPPPHLIIVPGELHFA
EAEALKEILGADEELVKSYRPPRYEKGRVQSYISKVEKVLSEVKIRMSSEKVIDSIEIVK
SYLEDSKKFLENGEVFNALAAISYAEGLLDSLKNIGYIDFDWPKT
>I3XPV8|diphthine synthase|EC 2.1.1.98|Desulfurococcus amylolyticus DSM 16532|TrEMBL
MLIFIGAGYSRRHLTQEALESLKSVEKIYVDTYTSIYEDGFNWLREVNPSAEIVFAKRRD
LEGEGINRIVEEAKDGNIAILCAGDPFTATTHDAIRVEALKSNVSVKVVTGISVVNLVHS
RIGLQAYRFGKIVTLVYPDSFKPYSVIETIYDNLGRNLHTLILLDLRLEEGLAMSIPEAI
DILMELDEKQQLMNQISIGVARLGWSSEVIRAGRLIELKRYSYPPPPHSLIIAARLHPIE
LESLRYIAGLTITG
>A0A8G1M4M0|diphthine synthase|EC 2.1.1.98|Salinarchaeum sp. IM2453|TrEMBL
MLSFVGLGLYDEQSITLRGQNRLQAADRVFIETYTSKLAGTTLDALSDFHGIEIEHRDRA
GVEQDPAPILDAAEAGHAAFVTAGDPMIATTHVDLRLRAAQRDIETEVIHGVTAQTAASS
LTGLQNYRFGPATTLPFPWAHGADGVPSSVIKTITDNLERDLHTLVFLDIKARRDEYMTA
DTGAELLAEAFDDQLAIGIARAGSDDPVLKADNLDALADYSFGKPLHMLVIPGTLHEMEA
QAVKAFCDGPTAVIDSQ
>A0A1V4ZXV3|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon PtaU1.Bin066|TrEMBL
MLTFIGLGLHDHKDVSMRGLECIREADHVFLEGYTSRLSGTSVSEMQAYFRRPIRVLGRE
DVEQHPEIVLDPAATGNVAFLTGGDPMVSTTHADLRIRAALRGIRTALIHGASISSAVCG
LTGLQNYRFGKSCSLPFPAKNWSPATPIEVIGKNLSQGLHTLVYLDIQEERCMTIPEAIV
LLEGLAEKAKVSIPLYVGVARAGSGAPVVFAGTAEKVTQADFGPPLHILVVPGPLHVVEE
EYLTMFGGL
>A0A7D5MA44|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotenuis sp. DW1|TrEMBL
MLWFVGLGISGPDSLSDKTKKIISGADVVYFEQFTSPMKNDESQKIKEITRGEFKFAPRW
LVEDGKEILDNSKIKNVVMVSYGDPYIATTHIELRTRAIQEKIQTDTVHASSAITSLVGE
CGLHYYKVGRTVTIMSGIPSSTAYYTIYENLRVGNHTVVLLEYNQNENFFLNPKDAIQSL
LESEKEQVRKVISDSTYGIIASRIGQQDQKIVAGSFASLKNRDFGNPPHTIVIPGTLHFT
ESDALSALAECVDKPNDNSSKIERIASQMMRKYIPMVRRALEQVIPYYKDAKEFHSVLEN
AELYIRDAELFFEQGKDELAILSIGYADGLVDALRIAKGLEPETNP
>A0A7J2I275|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLILIGLGLGDHTDITLKGLERVKKADKVYLDEYTSRFEDSARDLENFYGKKVIRATRDI
LESERLVEEAKKERVALLVVGDALSATTHIDLLMQAKKENIEVEVIHNASILTAIGTTGL
QLYKFGKTTSIPFWKENYKPENFYEVLQQNKSIGAHTLMLLDITPERCMTINEAIELLLK
TEEKRKEKIFDKTTLCIGCARIGSADQKIKAGTAEELMKEDFGEPLHCLIVPGELHFVEE
EAITFLR
>A0A7C1I701|diphthine synthase|EC 2.1.1.98|Methanomicrobia archaeon|TrEMBL
MLTFVGLGLYDERDITLKGLDAIRAADSVFAEFYTSPLGGKTIAKLEALYNKPIVLLERS
DLEEHADERILTLARDRDVVLLSGGDAMIATTHVDLRLRAIDAGIATQVIHAPSIASAVA
GLCGLQNYKFGKSATVTPPYKGIVSEVPYNTIQANKERGLHTLLYLDLTMRIADALALLE
TVEDTRGGTLLKTSVCVGIARAGSADPVVKADYPAALKRYEFGALPHVLVVPGELHFMER
EALIKIAQAPEDT
>A0A2R6JB16|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_7_68_65|TrEMBL
MLTFVGLGLYDERSITVEGRDALDDADRVFAEFYTSKLSGASVADLEAYHGTEIEVRDRS
GVEQDPEPILDAAARGGAAFVVAGDPMISTTHTDLRLRAHERDVATRVIHGTTAQAAASS
LTGLQNYRFGKATTIPFAYGDNGGGAPDSVLDTIDANRERGLHTLCYLDIRAAEDRYMTA
STAAERLVPGLDDPLGVVVARAGSPDPVVAADRLSALADRSFGALLHLLVIPGDLHHVER
DALAGLADAPEDIV
>A0A7J4RJH4|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MENGNETGFSLIGIGPGKVESMTIEAIEAAKNSGVRLYEAYTALWPESELEKLEAMVGPI
ERIMRPAVERPEELFQRAQTTSIAILVVGDPMQATTHIDFQLRAEKQGLPCRVIHGISVT
TLVPGSTGLSDYKFGRSTTLTYPYGDWVVTSPLEVMLRNQMQGLHTLVLFDLDPTGAGTG
DQRPMQPSDALASIEKMATKLRDSVVDDAIKEQARSVFDSMCVLCSDLGTDDALMKTTTI
RHLGEVPGGRLNCMVFLANTSEMEQEAINRWK
>A0A7J4EGM0|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSKGELIFIGLGLYDEKDISVKGLEAARFCDILYAEFYTSTLTGASLSRLEKHIGKHITV
LEREAVEQGKIILDAAQEKRVGFLTAGDTMAATTHIDLRLRAEKKGIKTRVIHGSSIFTA
VPGLLGLQHYKFGRSTTLVFPEKSFFPTSPYTVVQENLERGLHTLVLLDFNRETNRYMTI
AEGVDLLLEMAGNVDSTLIDENTLMCGVARAGSPDPMVKAGSAKLLRKIDFGPPLHTLVV
PGFLHFMEKKALETFVGLQGKR
>A0A2H9R2B4|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon CG_4_9_14_3_um_filter_37_18|TrEMBL
MLNLMGLGLSDEKGLTLEGLETLKKSDKVYIELYTSKWFGSIENLEKMTGKKIMQLKRPD
LEENLEKILKEAKNQTISILIFGDPLVATTHTALLIEAKKLGIKTRVIHNASIYSAAGET
GLHLYKFGATVTIPFLEKMNNQFPKSVSKIIRDNKGRDLHTLCLLDLISEKEKYMTPSEG
MEVLLKSDDITQEDEIVIFGRAGSEEPLIAYGKIKNLIDKDFGNPPFVLIILGKLHFTEK
EYLEYHRAD
>A0A497HN51|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGRLIFIGTGLMGGDWITTRGIEAAREVDFLFAEFYTSYIGDGGVKRLENILGRRIVRLS
RDEVEMKERLFKYLEDGDVGLLVGGDPMAATTHVELRLEAERRGHRTEVVYGVSIFSAAP
SSVGLQHYKFGRVVSVPWVSEKFMPRSVLEGIKGNLRCGLHTLLLLDLKDGEGFMSVNEC
LRTLLKLEEMHEMGVVNEETLVVGAARIGDPTECIKGGALSEMLEENFGPPLHVVVIPGR
LHFVEEEALRTIAGVRDDVLERWKNKIESFCPKGPTPS
>A0A497H1G1|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MLSFVGLGLWDERDITVKGLEEVRNCDVAYAEFYTSKMGVGIERIEELAGKKIHVLSREE
VEDGERILHEAEKKHVCLLAGGDTMAATTHVDLRIRAVERGIPTRVVHGVSIVSAAAGLL
GLQVYKFGKVVSIARPQPNFFPLSPYDAIRDNMTMGLHSLLLLDTTGGYMTANEALELLL
EMEERKRENLIGEDTPIAVVARISSDDALARAGCLGELRKQDFGSTPHSVVLFGKLHFME
VRALVTLAHAQEKIFKK
>A0A7J2SRR0|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MSKGELLFIGLGLYDEKDISVKGLEAARACDILYAEFYTSRLTGTSLSSLEKHVGKHITV
LEREAVEQGKIILDAAQEKRVGFLTAGDTMAATTHVDLRLRAEKKGIKTRVIHGSSVFTA
VPGLLGLQHYKFGRSTTLVFPEKSFFPTSPYTVVQENQERGLHTLILLDINRETNRYMTI
AEGVDLLLEMARNAGSALIDENTLMCGVARAGSHDPVVKAGPAKLLKNMDFGPPLHTLVV
PGSLHFMEEKALEIFAGLQRKR
>F0NQY4|diphthine synthase|EC 2.1.1.98|Sulfolobus islandicus (strain HVE10/4)|TrEMBL
MSILSLVGLGISKKFITENAIDTLNNSDIIIFDKYTSRSCDINVDVLRRLVKGGKTLIEA
DRSLLENNSKIIMDYLDKNYNVSIASIGDVLIATTHVSLLIEAKQRGHNVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKSERAMTAN
EALQILLRLEDKHRKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIP
GNLHYMEADAIKWMLMS
>A0A256ZEY8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon ex4484_135|TrEMBL
MGKGQLIFVGLGLHNEEGMTLRGLKVTREADVVFLEHYTSLMPGLSVRKLEELIGKPIKV
VDRQVLEEEDAEPLISEALRGRKVVLLVPGDPMIATTHVAVRLKAEKAGVRTSVINGPSI
INAVVALTGLQSYRFGRMVTITYPEGGVLSRTPYEVLWENKARNLHTICLLDARAEEGLY
MTVREGLEVMLKLEEELGRGLLRPDSLAVGIARAGSPEPVVKADSIKALMDYDFGPPPHT
LVFPASLHFLEAEALKVLTGAPDWVIRCGA
>A0A238V238|diphthine synthase|EC 2.1.1.98|Halorubrum chaoviator (strain DSM 11365 / JCM 9573 / AUS-1)|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A1G9QVB9|diphthine synthase|EC 2.1.1.98|Halogranum gelatinilyticum|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRAFAEFYTSKLIGTTVEDLAAHHDVDIEVRDRA
GTEQDPEAILDAAEEEDVAFLTAGDTMISTTHVDLRLRAIDRGIETRVIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGGDDVPQSVIDSIEANLERGLHTLVYLDIKAHRDEYMSA
STAAEMFADGWKDTVAVVVARAGSPDPLVAADKLSALAERDFGDPLHMLVIPGDLHHVEA
EALEQLGGCPSDLLEPL
>A0A846N7Q8|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MLWFVGLGISGAKSIPLEAQEVLGKADIVYLEQFTSPIGKSDLTKIKKMTKGQFKTAKRW
QVEDGNEILKNAKRKKIVLLSYGDPYIATTHIELRARAIEEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSDMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKEAIIG
LLETEKGQKRNVINPNTHAIVASRIGFKDQSIVSGNFSSLKKQDFGKPPHTVIITGRLHF
TESDALKIFGKCIDEPSDNSEKTKKISVQMMKKYVPMVREALEEVEPLYKDQKEFQTILE
NAELYIQDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGMEPKM
>A0A498FQW0|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Atlit-9R|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAYHGVNVEVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAADLLAEGWADELAVAVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLADAPEALVEE
>A0A0Q2ULI0|diphthine synthase|EC 2.1.1.98|Thermococcus thioreducens|TrEMBL
MAIYFIGLGLYDEKDITLKGLEVARKCDLVFAEFYTSLLAGTTLDRVEELIGKPIRRLSR
EEVELYFERIVLNKAREKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENQERGLHTMLFLDIKADQNRYMTANE
AMEILLQVEDMKKENVFTPDTLVVVLARAGSLNPTLKAGYVRDMIKEDFGRQPHVMVVPG
RLHVVEAEYLVAFAGAPKEILDET
>A0A7J3J1J9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLYDESGISLRGLMEAQGADTVFVELYTSLMPGLSLTRLTELMGRNLTILS
RREIEDENGEVILKAAQRGRAVLLVPGDPMIATTHVALRIEAEKRGIKTRIIHGSSIISA
AIGLSGLHSYKFGRSVTIPFQENFSETPYNVIAENKERGLHTLCLLDIDAERRRYLMISE
ALEMLLTIEDRKRRGVVTSETLVVGVARAGGPNPVVKADIVSKILKYDFGPPPYTIIFPG
NLHFTEAEALITFAGAPKEIRDSVK
>A0A2G4JD04|diphthine synthase|EC 2.1.1.98|Nitrosarchaeum sp|TrEMBL
MLWFVGLGISGSKSIPVEAIEVLSKADIVYLEQFTSPIEKSDMLKIKKITNAEFKEGKRW
LVEDGKEILKYAKTKKVVLLSYGDPYIATTHIELRTRAIKEKIKTFSIHASSSLTSMIGE
CGLHFYKLGRTATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKNYFMDPKEALEG
LLETEKGEKRNVINLGTHVIVASRIGFKDQSIISGKISSLKKIDFGKPPHTVIITGRLHF
TESDALKILGKCHDEPHDNSEKTEKIALQMMKKYVPMVREALEEIIPLYKDQKEFKVILD
NAELYIQDAEKFLEDGQDEVAVLSIGYADGLVDALRLAKGLEPKM
>A0A1I6LZK5|diphthine synthase|EC 2.1.1.98|Halomicrobium zhouii|TrEMBL
MLTFVGLGLYDERSITVEGREALQTADQIFAEFYTSKLVGTDLQRLEYYHDASFEILDRA
GVEQDPEPVLEAAESEDVAFVTAGDTMISTTHVDLRLRAHERGIRTRIVHGTTAQTAASS
LTGLQNYRFGKETTLPFPDAHGGGDVPDSVVDTIEDNRDRNLHTLVYLDIKVDDPHWDGD
EEFMRGDQAASLLADEFGSYLGVVVARAGSANPVVAADRIDHLADEDFGRPLHLLIVPGN
LHDMERDALVELGDAPDDVV
>A0A0F8E2R1|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. 2.H.A.1B.4|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEQLYGKKVHLLSRE
DVEQQPDWLDEAKDKNVAFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARVISETPYDTIKQNSELGLHTLVFLDIDKDKGYMTV
NLALELLLEVEAKRGESVMDMAVAVGIARAGSEKPVVKADYAENLKDFDFGKPLHILVVP
GKLHFLEAEALVKLADGPEEIMEETE
>A0A151E973|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon SM23-78|TrEMBL
MTLYLIGIGLWDEKDITVKGLEAVMQCEKVFLESYTSRLGVDFKKLQEYYGKKIILANRE
LVEKNANKILEPAKDSNVALLVIGDVFGATTHLDLYLRAKKENIDVVIINNASILNAVGI
VGLELYKYGKTTSIPFHNKNVETPYDVIKHNKASKLHTLLLLDIDAENNRFMTIKQAIEY
LLRVEDKRKEKVFTKQTKCIGVARLGSEKPKIVYDTAEKLLKTDFGEPMHSLIVPSKLHF
VEEDALKIWKK
>A0A2G9PJP2|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG08_land_8_20_14_0_20_47_9|TrEMBL
MSLTLIGLGLCDYNDISLRGLEALKQADVVYFENFTNILACSIKEMEKAYGRMITPVKRE
FLEPGEGLIAEAQSRRVALLVIGDPLTATTHISLFLRAKEKGVAVEVIHNASVMSAVAIT
GLQPYKFGMTSSLPFPGSSFKPETAYEVIKRNKASGMHTLLLLDLKPDEGRFMGIGEAID
ILLSIEEKRLDGVFATNTPCIGCARLGWPDCRIICGKASELRKADFGKPPHCLVVPGSLH
FVEEEAIGGYRLNHS
>A0A7V4U3V7|diphthine synthase|EC 2.1.1.98|Nitrospirae bacterium|TrEMBL
MLYLIGLGLEVKDLSIKALEAIKKCKDIYLEHYTTKLPYDIKELEKVTKKKVWILSRERV
ESDFLIHEAKKKNIALLVYGDPLAATTHISLLREAEKKKIPVSILHNVSVLNAVLDTGLH
AYKFGKITSIPRWQENYRPRSFFTIVKENLSIQAHTLLLVDPGLNPSEALKELNEASEYA
LDDKFIIVCSKLGTQKQEIIFAKLKELVKKTPKVKEPFCIIVPAKMHFSEEEILYRKIKI
>A0A533UVE4|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
TMEICSSIEILNKCDRIYLERFTSPISDNYITFLKSALPEKKIEIVKRWFVEDGRQILDE
SKVMNVGLVSYGDPTIATTFSELRVRAIKNNIEAKVLHAASGITCLVGECGLQIYKIGKV
VTMMEERQSAISVYNTIFNNLNQNCHTIVLAEYRLAEDNSVFFLKPNYIMSRLLEVEKDI
AYKIVSKDSFLIVASRIGTDSQNIVSGKIGSLLEQEYGAGPHSIIFPAKFHFTEEEAIIN
LTKHLDGPADNTGSLKSVSAQMLEKYEPMIRKEIKQIRDIITSKKETKIQLEILDNAEYY
LDDAIQFLEQGKQELAILSVGYADGLVDSLRQILELV
>A0A7J2H694|diphthine synthase|EC 2.1.1.98|Thermofilaceae archaeon|TrEMBL
DLRDLSIGALRALKRASKVFVEMYTSIVPGLNFEKLEELVGKRVEELRRSDLEGEGLDRL
VSLAEKEDVALLVPGDPFLATTHIIVKLEAMRRGVRVEVFHAPSILNAVLSSTGLQVYKF
GRPVTIVKPTHAYRPTTPYRVLAENLSRGLHTLFFLDLKLEEGYAMTALEGIRILREFEE
ELKNKVVGPQTPFIVVARAASPDELVKVLRLGERAELGPPPHTLIVPGILNPVEIEALEV
IANADRSFLEEWNRFVKSLMEFR
>A0A7C4XGA0|diphthine synthase|EC 2.1.1.98|Acidilobales archaeon|TrEMBL
MKGKLYIVGIGLTPEYLTIRALKILRRVKKVFLDSYTSLLVDDDVKLKEVLGSDYEMLGR
RDLEDLNGEKVFNALNEGDVALLSPGDPLIATTHVNIVIEARRRGYEVEIVPGVSIVSAA
VSFTGLMIYKLGKIATVTYPKNGILYEYPYDVVKENSLRNLHTLLLLEVDVDKSIYMSVK
EAIQILLRIESLRREGVITYDKLAIGISRLGGEDMKICPDSLGNLMSMDLGGPPHSLIIT
APKLHFIEEEALKVVKDVYCR
>A0A097QTF3|diphthine synthase|EC 2.1.1.98|Thermococcus eurythermalis|TrEMBL
MALYFIGLGLYDEKDITLKGLETARKCDKVFAEFYTSLLAGTTIDKIEELIGKPIMRLSR
EDVELNFERIVLPEAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEGNWFPTSHYDVIKENRERGLHTLLFLDIKADQNRYMTANE
AMEILLQVEGMKKAGVFTPETLVVVLARAGSLNPTIRAGYVKELIDEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPKELLEEV
>A0A6V8CU24|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MDSSGLFLIGLGPGDLALMTRRAIDMLQDMDERYLEGYTATLPLTQENELENLVGPWKRV
MRPQIENPREIIEMAKSLKVAIMVVGDPMQATTHVDLILRARENGVKVTIVPGISATTLA
ISSSGLQSYRFGRQVTLPYAYGDYLPTSPLRYILDNRLRNLHTLVLLDLDPTGLGIESPI
HMSPSVARQILMQMAERWSGENEEVNVSAWNVVVLSDLGTAQGHVCSTIIEEMNGMESGR
IHCLILPAEMDNHEQMVFDSMRYHA
>A0A2A5NZP8|diphthine synthase|EC 2.1.1.98|Candidatus Geothermarchaeota archaeon ex4572_27|TrEMBL
MMMPRVYIIGLGLGGWRGLPLEGLEAIRRVSRVLVDTYTNPISDEDLREISRLSGKKVSK
LRRGDVEEGDAVFRAAEEGDIAILCGGDPLIATTHQQLVRELRRRGHEVRVIHGASVVTA
AIGRSGLHVYKFGPPRTLMRPDVAPPGEVLRVLAENISRGLHTLVLLEYDAASGYVMGGR
EALEILYDSQRRMGARLPERGRPTLVMARLGYPDEEVVALRWGELPRGEVPGPAVIIVAG
SLHFTEREYLRDIFGLDV
>V4K989|diphthine synthase|EC 2.1.1.98|uncultured Acidilobus sp. OSP8|TrEMBL
MLFIIGAGLGPQHVTDLAKSLIKRAEVVIVEAYTSPNSDWLEDLAKALNKATVKATRDML
EENVNKLIDMARYRDVVVLVAGDPLIATTHSSVVVEALTRGVKVKVIPSVSGPCAAMSLS
GLQFYRFGRKVTVPGPWRGADVTPVAYWLLGNLCLDLHSLILLDVDQEGRQLPPADGTRE
LLKAFNELLSDQKENLGDLLVLAVSATDNDVYVTYSRLSEPEALRPITPSTMIVPASLHP
VEQEFLKLVHGVPSGLIDLHLKLLRRIDPCNLYFSARHKVMASP
>A0A7J2MUN5|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MNVFVRKSGTSFVLKSMKEEIRSKKRAAKIKVISIILLKERIRILKICSLRNFKNCLSLR
IDMLYLVGLGISGDLTLSGLEVVRKANRVYYESYTSLIDEGSIRKLEKLAGKKFEKVERR
DLEDNVKSLVEQAKESDICILVPGDPLIATTHISIILEAESLGIKYQVIHNSSIFPSICE
IGIQIYKIGRITSIPLKEENFDPESFYEVIEDNLKRGLHTIILLEARSEREFVSINEAIR
RILELSKERNGTITPKSLGVGISRLGFKDFIIKFGKLEELETFNFGKPPHTLLILGKLHF
VEEEALKRFR
>A0A497SHT7|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYLISMGLRDEKDVSVRGIEAAKACDSLYAEFYTNMTATSSDMLSKMAGKPVKELDRKG
MEDDASLLIEEARKKDVGIFIPGDALSATTHLMLLSEAVEAGVRYKVIHGSSIFTAVAET
GLQLYKFGRTVTVTNPVGESTLDAIRKNMSADLHTLALLNIEMDAIEGIDALYDIIKGKR
IVAACCLGSDEQVIRYGRPDELLKLNELKGRLPAIIAIPGEMHFTEE
>A0A2I0PBE7|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon HGW-Methanomicrobiales-2|TrEMBL
MLMFVGLGLYDLGDISVKGLEYVRNADAVYLESYTSRLMGTDVSAMEAFFGKEVRVLGRE
DVEGDPREILERAAIGRVAFLTGGDPMVSTTHADLRMRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPIETVAANLAQNLHTLVYLDIQKDHYMRIPEAVA
LLEEMAEKRGIEPPVLYVGIARAGSESPVVAAGTAERLKETEFGAPLHILVVPADLHPME
REYLEIFAGL
>G0QAJ4|diphthine synthase|EC 2.1.1.98|Nanosalinarum sp. (strain J07AB56)|TrEMBL
MTLHFVGLGLNSEGISLEGLRRLEEADAAFVEFYTNLEMDLSGVEERTGAEIEELPRAEV
EREMLPVEAAESGDAVFLVPGDPFAATTHQELRREAEERDLEVSVSHAGSVLTAVGETGL
DLYRFGRTVTLPSHGCPPSVVNMIAENDSVGLHTMVLLDPGLGIGEAAEMLRQEIDNSRC
VACSRLGTDQSSTEVADLSEVEGGGSGPHCLVLMGDTTDKEEEYIG
>A0A842KTS1|diphthine synthase|EC 2.1.1.98|Methanobacteriaceae archaeon|TrEMBL
MLYIIGLGLYDENDISIKGMKTLKECDRIFAEFYTAKLK
>A0A7C5U0D4|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MLIFLGLGYSKRHLTIEAIEALKSADVIYIDTYTSMYEESIDQIKELNPRAEYRCASRKD
LEDSSIEKILEEAGSKVVVIAVPGDPFIATTHDAIWISALKKGIEVKVVNGLSFITLAYS
RLGLQSYKFGRHVTLVHPLLFKSYSTVDVIYSNMERNLHTIVLLDLRVEENYAMTINEAV
QILLNLDYKGKLRDQLALGIARLGWRDEKVCAGKLGDLSTFKYPPPPYSLVILSPRLDPI
EKEFVELWTTLC
>A0A2G9N5L4|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_44_13|TrEMBL
MALYIIGIGLSDEKDITVKGLEIVKKADFVYLENYTSILQCPISHLEKLYGKRIILTDRD
MVEKRADEILEKAKTKDVAFLVVGDPMSATTHIDLMLRAKEKDIDVRVIHNASILTAVGI
TGLQLYKFGKTTSIPFPENVKAETPYNVIEMNRKNNMHTLVLLDIDVEKNKFMKVDEAIR
ILLGIEKNKKKDMITDETSMIGCARLGSDDQFIKAGKAKDLLEVDFGKPPHCLIMPAEMH
FMEEEALKEFC
>A0A7C4BBH9|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MLRLIGIGLSIDMLPLGNLKKILSCDEIVVDSYTSIWFPSAYLLTSLLIQLGKTVIIAPR
NYLEGSEVKNLIKRALDKEVCILVTGDPLIATTHSSIITEALANNVEVEVVPAASIFNVS
ISLSCLQVYRFGKIVTVVSPKNGIVYEYPYDVIKMNRLQNLHTLLLLEIDVEKNYYMKPY
EAIKILLDIQERREENIISLKDIAIILGDVLSCRQKIWILTIEEILRMQYEFLYNKLYTM
IIPSRKLHPVEEECLNLIRKGKMSYLCAISEEELKKIAQLIYNQ
>A0A843DBN6|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGLECLKNVDKIYAEFFTSRLFGSSFDKIEELIGKEIEVLVRG
EVEEEHKFIDEAKDSDVALITGGDPLIATTHSDFLVQCSKKGIEYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEAIEENLKSNLHTLVLLDIQAHKDRYMTVNQGL
EYLMNIKESIDYEGLINEDTLAMGIARVGSSGVIVKAGKIADLIDFDFGGPLHCIVIPAD
LHIVEAEYLVEIAGADSSILDDV
>M0HM70|diphthine synthase|EC 2.1.1.98|Haloferax larsenii JCM 13917|TrEMBL
MLTFIGLGLYDERSITVEGAEALEAADRAFAEFYTSHLVGASVSDLESYHDIDIEVRDRA
GVEQDPEEILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPFVHGGDPVPQSVVDSLEANRERGLHTLVYLDIKVEWEGRRGV
EIDDDEYMTADYAAELFAEHWDPDALGVAVCRAGSPNPVVAADRLEALAERDFGEPLHML
IIPGEVHHVEADALMALGGAPADRFDDF
>A0A343TFA2|diphthine synthase|EC 2.1.1.98|Halalkaliarchaeum desulfuricum|TrEMBL
MFLHYITVAWYLSSDRSRECPPSTGMPGAYLPSLPSAGMLTFIGLGLYDERSVTVEGQEA
LRSADRAFAEFYTSRLIGTDIETLEAYHGTEIEVRDREGVERDPEPILEAAAGGNVAFLT
AGDTMISTTHVDLRLRAHERGIDTRVIHGVTAESAAAGLTGLQNYRFGKAVTLPFPYAHG
GEGVPDSVLDSVEANRDRGLHTLVYLDIKVGTGPRGPDPDHEEYMTADVAADLLASAWRD
ELGVVVARAGSPDPVVAADRLSALADRSFGDPLHLLVVPGDLHHVEADALAGLAGAPAEL
LGE
>T1BNP5|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
MAELWFVGLGLGDERDLSRRGEEVLRRCERIFAEEYTAVLEDGALDRLAKEIGHRIDRLG
RTDVESERTILDALDRSERVGFVTAGDPFAATTHVALRLAAERAGHTWRYVPNASIFTAA
SGFLGLMAYRFGRTVSLPFPAPGFAPTSPVVEIGKNRLIGAHTLVLLDLHPSEGRFLTAG
EAIRILLERDPEHVGIAADREIAVVARMGSETADAWVGPALELSRTEFGPPLHALVILAP
ELHFAENEALARFRRPAPSSS
>T1A636|diphthine synthase|EC 2.1.1.98|mine drainage metagenome|TrEMBL
MQVVATPIGNLGDLSTRAREALSRADAVVAEDTRRTRTLL
>A0A847PRI7|diphthine synthase|EC 2.1.1.98|Methanosarcina sp|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIRKADLVYAEFYTSCLMGTNLEKMEKLYGKKIFLLSRE
DVEQYPDWLNEARDRKLCFLTGGDTMVSTTHVDLRLRAEKLGIETRLIHGASIASAVSGL
IGLQNYRFGKSASIPHPYESRRGTRVISETPYDIIKQNSELGLHTLVFLDIDQEKGYMTV
NTALELLLEVEERREEGVIHGTAAVGIARAGSENPVVKADYVENLKDFDFGEPLHILVIP
GKLHFLEAEALVKLAGGPIGFMREVE
>A0A1D2UYY3|diphthine synthase|EC 2.1.1.98|Methanohalophilus sp. 2-GBenrich|TrEMBL
MLYFVGLGLFDEKDVSVKGLEVIKNAGKVYVEFYTSRLMGADKEKMENLYGREIHVLDRQ
EVEQDPWWLEEAKEINIAFLTGGDTMVSTTHVDIRLRAMEMGIETCLIHGASIVSAICGL
TGLQNYRFGKAATIPYPYTSTRGNTIISETPYDTILHNRQMGLHTAVFLDIDMDKGYMTV
NQGIELLLQVDEKRGENLIKGSIAVGIANAGSEKPIVRADFAENLESCDFGSPLHIVVIP
ADLHFVEAESLIKLADAPESILEEGDIN
>A0A117SN05|diphthine synthase|EC 2.1.1.98|Vulcanisaeta sp. JCHS_4|TrEMBL
MGKKNPTLYLVGLGLSPGNLTIDALNIIRSVDKVFMETYTSKAPGELIKQIMGIRHDVVF
LSREDLEDRSGNAIMSELSKGRNAALLVIGDPMMATAHAAILVIAKRLGFEVKVINSVSI
VCAILSQLGLSPYKLGPIATITYPRMGILSMRAYELLNDNLRRGLHTILLLDIKDGNEFM
SAGEAIDLLRKMEENGKLGIINNDLLVIYAARIGWENQSIVVSTISNVPSLGETPHTIII
PGLLNPVEIDYLTYVLNADKDLVLKHQRWVNKLMNGNWQK
>A0A1F5DG55|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon RBG_13_60_20|TrEMBL
MTLTLVSVGLSSHLDLSLRAIEAAKSAHHVYAEEYTMRLDTTVETLEATIGRPVTPLPRG
GMEEDASRLLEAAENSDIAILVGGDALAATTHLSLLVDAARRSIPVKVVHGSSVFTAIAE
SGLSLYKFGRTVTVPMPEKGPVDTVLRTLKENAEYGLHTLLLLDLDVPAGRYLTVPEAIT
RLEKTGEFPLDTLVVAAARLGSDSQIIRADAALNLKDADYGGPPYALVVPGQLHFLEEEA
LQVMAGCPPGLLEGRRVQGELDRLVEKYVKGCRRVLEVIKVAELPSELTGEAVTGLLDHA
RRYLEDADYYRVEQKPVALASVAYAEGVLDALKLLGLADFQW
>A0A3N6MKV7|diphthine synthase|EC 2.1.1.98|Natrarchaeobius chitinivorans|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSELIGTTVADLESHHDVEIEVRDRA
GVEQRPDDVLEAAASEDVAFLTAGDTMISTTHVDLRLRAHERGIDTRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDDNRADGLHTVVYLDIKVGHERAEED
EYMTADVGAALLADAYPDLVGVVVARAGSPDPLVEAGTMSDLADREFGDPLHLLVVPGDC
HHLEADALVELAGADRAALDVV
>A0A832LZC4|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGVGLYGLRDITLGTLEYLRKADRIFIELYTSIVPGFRVKDLEGLIGKKVTPVRRE
DLEGGWLNELIKMAERELVVLLAPGDPFIATTHISLRLEAAKRGVSVKVLPSPSVVNAVS
ASTGLDFYKFCRPVTIVRPSPSYFPSTPYRVLRENLARGLHTLFLLDLNVEQGYAMTANE
AVDLLLELERREGGSILDEDALLVAVARATSPDEVVAAFTPARRPDLGPPPHLLIVPGLL
NAVEAEALQTLAGASADLIKRWCSKVKALMGDSCY
>A0A7C2L8X6|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGLGLYGLRDVTLGALEYLRKADRVFLELYTSIVPGFKVEDLERLIGKRVTLVRRG
DLEGPWLRELIGMAERELVVLLAPGDPFIATTHVSLRLEAAKRGVEVRVLPSPSVVNAVS
ASTGLDFYKFCRPVTIVRPSPGYFPSTPYRVLRENLARGLHTLFLLDLDVERGYAMTASE
AVDVLLELERREGGDVLGEDALLVAVARATSHDEVVAAFTPTQRPDLGEPPHILVVPGLL
NAVEAEALQTLAGAPADLVKRWCSKVSALVASGPFRQSNNDSRCARLI
>A0A843DGW3|diphthine synthase|EC 2.1.1.98|Methanocorpusculum sp|TrEMBL
MLTFIGLGLFDEYDVSVRGLDAIRNADTVFLEVYTSVLMGSSIERLEEYYGKKITPLYRE
DVEIHSDKIINAAKEGDAVFLTAGDSMVATTHSDIRCRCAEAGVETKIIHGASITTAVCG
LSGLQNYRFGKSVSVPFPYGKWFPMTPI
>A0A1V5ADU9|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaU1.Bin028|TrEMBL
MLFFVGLGLFDELDISVRGLEVVRQADLVLAEFYTSRLMGSSAKRLSQLYGRPVTLLSRS
DVEESPGWLSEARDKDVAFLVGGDPMISTTHLDLRLRAEEMGIPTRVIHSSTIASAVPGL
TGLQNYRFGRSASIPFPYKARGKRIVPETPYMVFSENRRQNLHTLLYLDIQEDNFMTVNQ
GIECLLEVAVAGGETELGQALGVGVARAGSDGCMVRAGTLSQLVEIDFGPPLHILVMPGG
LHFMEARALQVLAKAPPELVRRFEI
>R9TAP9|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccus intestinalis (strain Issoire-Mx1)|TrEMBL
MGEIIFVGLGMSKPEDMSVKALETLRSSDKIFAEFYTSKLIDSSIEDLENFIGKKITVLK
RSDVEEHDTIIEEAKCGKVSFVTAGDPMSATTHVDIRLRAEKENIPTKLVHGVSIFTACA
AAFGLQPYKFGRAVTIPFPEPGFLPASPYDNILENFERGLHTLILLDIKADESRYMTANI
AMQWLLDAEERLHKNLITDTSLFCAGARIGSSTQKLVAGSPNSILCADLGSPLHCLVMPG
KLHFMEAESLCAFAGAPKSILNAD
>A0A498F706|diphthine synthase|EC 2.1.1.98|Halorubrum sp. Atlit-28R|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLIGADVADLEAYHDVDIAVRDRA
GVERDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETVEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADAAAELLAEGWADELAVAVARAGSPDAVVAADRLSALADRQFGDPLHLLVI
PGDLHHVEADALVGLADAPDALVEE
>A0A151BPK9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon B26-2|TrEMBL
MGELTFVGLGLFDELDISLKGVEAARRADVVYAELYTSLMRGLSLENLQNLIGKEVHVVG
RRLIEEEGSEPILERAEESRVVLLVPGDPLIATTHIDLRLRAERRGIKTRVIHAASILSA
AIGLSGLQNYRFGKNVTVPFPEPSLVYETPYMVIYENKVRDLHTLCFLDIRVEESKFMTV
KEGLRALFEVEKRKRLRAVTSRSLAIGVARAGSDDAVVKADYVERLMEYNFGPPPHTLIF
PAGRLHFVEAEALITLAGAPEDIRGMVT
>A0A1V4ZE93|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon PtaU1.Bin124|TrEMBL
MSLKALQELRSCDAVYGEFYTSKLIDSSVEDLETLIGKKVIRLRRVDVEEGEQMIEAAGS
KKVAFVTAGDTMAATTHVDIRIRAEEAGIKTRLIHGTSIFSAAPSSLGLQPYKFGRTVTL
PFPEPGYTPLSPYERILENKQRGLHTLVLLDIREEEGRYMTSQQAVRWLMDAEQRAGSGL
IADDTIICACARLGARDEKVLAGYPDDIVSVDMGAPLHTLVIPGKLHFMEAMALVTLAGA
PKEIAKEE
>A0A218P1Q3|diphthine synthase|EC 2.1.1.98|Thermococcus celer Vu 13 = JCM 8558|TrEMBL
MAIYFIGLGLYDERDVTLKGLETARKCEKVFAEFYTSLMAGTTLERIEELIGKPIRRLSR
EDVELNFEEIVLSEARDKDVAFLTAGDPMVATTHSDLRIRAKKLGIESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRENRERGLHTMLFLDVKAEQNRYMTANE
AMEILLRVEDMKKENVFTGDTLVVVLARAGSLNPTLKAGYVRDMLKEDFGKQPHVMVVPG
RLHIVEAEYLVAFAGAPEEILKEV
>A0A151BR13|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon B26-1|TrEMBL
MGELTFIGLGLFDELGISLRGLEEAKKADYVYAELYTSLMGGLSIESLQNLIGKEVHVVD
RRLMEDESGEPILEKAEESRVVLLVPGDPLIATTHIDLRLRAERRGIRTRVVHAASILSA
ATGLSGLQNYRFGRNVTIPFPEPGFVYETPYEVIRENRGRDLHTLCFLDIRVEEGRFMTV
KEGLEALLKVEEEKKLGVVTPRSLAVGVARVGSDNAVVKADYVERLMGYNFGPPPHTLII
PAGRLHFVEAEALITLAGAPAEIREMVT
>L9VTC3|diphthine synthase|EC 2.1.1.98|Natronorubrum tibetense GA33|TrEMBL
MLTFIGLGLYDERSITVEGRSELRNADRAYAEFYTSKLIGTSVEDLESHHDVEIEVRDRA
GVEQHPEDILEAAETEDVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGHPASVSNTIDDNRADGLHTVVYLDIKVDNEAATNR
LETDETLEEYMTADVGAELLAEEYPDLAGVVVARAGSPDPLVEAGTMADLAEREFGDPLH
LLVVPGDCHLLEADALVELAGADRDDLDVV
>A0A6G0EE58|diphthine synthase|EC 2.1.1.98|Haloferax sp. CBA1148|TrEMBL
MLTFIGLGLFDERSITVEGREALADADRAFAEFYTSHLVGATVEDLEAYHDIDIDVRDRA
GVEQDPDAILDAAEQEHVVFLTAGDTMISTTHVDLRLRAEERGIETRVIHGVTAQTAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRERGLHTLVYLDIKVDWEGRRGV
DVEGDEYMTADYAAELFAEHWDGDALGVAVCRAGSPNPVVAADRLSELAGRDFGDPLHML
IIPGEVHHVEADALMGLGGAPTDLFDHDER
>A0A4V6E307|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SS7|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAYHDVDVDVRDRA
GVEQDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAADLLAEGWRDELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLADAPEALVEE
>H6QCZ2|diphthine synthase|EC 2.1.1.98|Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)|TrEMBL
MGVGPGPGYVTEAAAKALADADCVFYEDYTGPLHLESIRRYAKTEPIRLTRRDLEDESGR
AILQCLEKGGRAVLATAGDPMLATAHAAVVAAARRRGHRVEVVPGVSIICAAMSAGCLSV
YKLGGVATVTYPRGGVYSRRPYELAEQNIKRGMHTLLLLDVKEDGSFMPPRDAAAVLLAL
ERLEGRGVFKPETPVVLVHRLGWGGGAKYTNLAQIAASDYEGPAVIIIPGVLGPVEEECL
QTLR
>A0A2I0PXD8|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon HGW-Methanomicrobiales-1|TrEMBL
MLTFVGLGLYDKTDVSEKGLACIRNADHVFLECYTSLLMGTTIEEMGNYYGKQIHPLFRE
DVEQHPEAMLEKAETGNVVFLCAGDPMVSTTHADLRMRAAKRGIKTAIIHAASIASAVCG
VSGLQNYRFGKSCSVPFPQKNWSPTTSIEVIAQNLSLRLHTLVYLDIQDERYMTVPEAVA
LLEDMAEKKGCRIPLYVGIARAGSAEPVIIAGPAERVRTGDFGPPLHILIVPAELHEMER
EYLEMFAGL
>A0A662N9W6|diphthine synthase|EC 2.1.1.98|Thermococci archaeon|TrEMBL
MPIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTTIEKIEQQIGKSIKLLSR
EDVELNFEKIVLNNAKERDVAFLTAGDPMVATTHADLRIRAKQMGVRSYVIHAPSIYSAI
SITGLQVYKFGKSATVAYPEKNWFPTSHYEVIKENKERGLHTLLFLDIKAEQKKYMTANE
AMNILLQVEEMKKEEIFTEDTLVVILARAGSLAPTLKAGYVREMIKGDFGKQPHILIVPG
KLHIVEAEYLVEFANAPKEILKEV
>A0A2R6DC74|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QH_6_64_20|TrEMBL
MLTFVGLGLYDERSITIEGRDALADADRVFAEFYTSKLAGATTSDLEAFHDVDIEVRDRV
GIERDPEPLFDAARDSSVAVLVAGDPMIATTHVDLRLRATEREIDTRVVHGTTAQTAASS
LTGLQNYRFGKATTLPFAYGSGGVPESVLTTVSENHERGLHTLCYLDIEAEREAYMGADD
AARRLASAFGEDERFDAGEETLAVAIARAGSPAPTVRADRLSVLSTTDFGDPLHLLVVPG
DLHHVEADALEALAGAPEDLIGSYRVR
>A0A410TP92|diphthine synthase|EC 2.1.1.98|Halorubrum sp. BOL3-1|TrEMBL
MLTFIGLGLYDERSITVEGRAALRASDRVFAEFYTSRLVGADVGDIEASHDVDVEVRDRA
GVERDPEPILDAAGSGDAAFLTAGDTMISTTHTDLRLRAEERGIGTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETVEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADYAADLLAAAWEDALAVVVARAGSPDAVVAADRLSALAGREFGDPLHLLVI
PGDLHHVEADALAGLAGAPESLVGE
>A0A832TLB9|diphthine synthase|EC 2.1.1.98|Methanolinea sp|TrEMBL
MLTFIGLGLHDHKDVSMRGLECIREADHVFLEGYTSRLSGTSVSEMQAYFRRPIRVLGRE
DVEQHPEIVLDPAATGNVAFLTGGDPXDLRIRAALRGIRTALIHGASISSAVCGLTGLQN
YRFGKSCSLPFPAKNWSPATPIEVIGKNLSQGLHTLVYLDIQEERCMT
>A0A401H959|diphthine synthase|EC 2.1.1.98|Aeropyrum pernix|TrEMBL
MARGREAVTLLLVGWGYAPGMQTLEALDAVRRADIVYVESYTMPGSSWLYKSVVEAAGEA
RVVEASRRDLEERSREIVSRALDAVVAVVTAGDPMVATTHSSLAAEALEAGVAVRYIPGV
SGVQAARGATMLSFYRFGGTVTLPGPWRGVTPISVARRIYLNLCAGLHTTALLDVDERGV
QLSPAQGVSLLLEADREYAREAGAPPLLARLPSVLVEAGAGGGHRVLYWSSLERLSTAEV
EEGVYSIVIPARLSGVEEWLLAAASGQRRPLEYDRSVYEAVEENCKKGVYMEPV
>M0NYA3|diphthine synthase|EC 2.1.1.98|Halorubrum litoreum JCM 13561|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A0N0BR52|diphthine synthase|EC 2.1.1.98|Halorubrum tropicale|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLIGADVADLEAYHDVDIAVRDRA
GVEQDPEPILEAAADGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETVEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADAAAELLAEGWADELAVAVARAGSPDAVVAADRLSALADRQFGDPLHLLVI
PGDLHHVEADALVGLADAPDALVEE
>A0A7C4ND70|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MVLVFVGLGLEKGGISLRGIEEAKKADAVYLETYTSIVPGLSVSYLQELTGKKVKVLDRR
LLEEEPHEILEKARDGRVVLLIPGDPMVATTHIDLRLRAAKMNVETKIVHAGSILSAVAG
VCGLQSYKFGPSATIPFPDNPSARPYEVLADNRKRGFHTLLFLDIRAEEGRVMSANQGME
IMLGHELVRRESIFTPNTLVVVVARAGCEDELVRAGRVEEMLGVDFGPPPHSLVVPGRLH
FIEAEALKVFARAPEDAVDELVG
>A0A7C5P673|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLHDEFGISLKGLEEAKTADAVFLEAYTNFMPDFSLENFERLVGKRVVVVS
RKQLEDENGWVVLEAALKGKAVLLVPGDPLVATTHVAVRLEAQKRGIKTRIVHGASIVSA
VMGLCGLHNYKFGKSVTIPFPENFSETPYNVLAQNMRLGLHTLCLLDIDVEKNRFLTVRE
ALEMLLRVEAEKRFSVLGGETLAVGVARAGSINPTVKAGFVKELLGYDFGGPPYSLVFPG
RLHFMEAEALVVFAQAPPSVWRLVE
>A0A7J3FMW4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSELIFVGLGLHDCFDISLRGLEEVKRADYVFAEFYTSLMPGFKLEEFKKIVGKDIIIVS
RKNVEDEDGKIIFDKALHDRVAFLVPGDPMIATTHIALRIKAEKMGIKTKIIHGASILSA
AIGLSGLQNYRFGKSVTIPFPEGSIISQMPYIVISENKSRDLHTLCFLDVRAEEARYMRI
KEALEILIRLEEINRRGFLGEDSLAVGVARAGSEKPIVKADVIKDLVKFDFGDPPHILII
PADKLHFMEAEALIALAGAPRWVMEMIR
>A0A419KMB3|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTLIGLGLHDEKDISLKGLEEARKADIIFLEQYTSLMAGFSLGNLEKIIGKKVIVVDRKE
MEDKCGRVILENAKERSVALMVPGDPLIATTHIDLRIRAEKMGIKTRVIHAASIISAAIG
LSGLQNYRFGRSVTIPFPEGITYETPYLVIRENRERNLHTLCFLDVKAEESRFMTIREGL
EAMLKVEEKMKGRVVTPKTLVVGIARAGSSESVVRSGFIEELLHYDFGPPPHIIIFTAET
LHFMEAEALITLTGAPPEIRRMVK
>A0A7C6DWD6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGEIVFVGLGLHDEMDVSLKGLEEVKTADAVFIECYTSILPGFSLRRFEKLSGRTLRIVS
RRELEEENGESILKAAEKGKAVLLVPGDPFVATTHMALRLEANRRGIKTRIIHGASIISA
VVGLCGLQNYKFGRSITIPFPENYSETPYEVIAKNRKLGLHTLCFLDIDVEKERYLTIGD
ALKMLLETEEKRRMEAVTRENLAVGIARAGSPDPTVKADYVGELIFYDFGKPPHILVITG
KLHFMEAEALIAFAKAPISVRRIIE
>A0A524MXG1|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MWKHNPQTPKEEKHMITLISIGINSHLDLSLRAIETARDADKLYAETYTMKLDTTISELE
ETIGRPITPLQRNGLEEQADQLLKEAKTQNIAILVGGDALSATTHISLLLDAHDDKIETQ
VIHGSSIFTAITDTGLSLYKYGKTVTIPLPEKGPADTAIRTIKENTENGLHTLLLLDLNI
AENKYLTIPQAIKRLTDTGEFNLETLLVGVARLGSRFQIIKADTAANLMRYDFGEPPHAL
IAPGKLHFIEENALEILAGCPRKTIQNHNPVGETDRLITKYSTGCRHVLDTLKTRNLPAS
ITAEQVQELLRHTENYLEDAEYY
>A0A497F7K9|diphthine synthase|EC 2.1.1.98|Candidatus Verstraetearchaeota archaeon|TrEMBL
MLVFIGLGLNSEKDMSLEGLEAAKNADKVYIDTYTSFMPGLSLARLEEIIGKKIIKLKRK
DIESPKANEILEAASAGDVALLVPGDPFVATTHMQLRLEAERRGIKTRVIHASSIFSAIP
GETGLFSYKFGRAVTVTFPHGEHISETPYDVVKENLERGLHTLLLLD
>A0A3R8C716|diphthine synthase|EC 2.1.1.98|Methanocalculus sp. MSAO_Arc1|TrEMBL
MLTFIGLGLFDETDISLKGLSAIQAADALFLETYTSRLMGSDPAVMEQLYGKPITLLSRE
DVEQHPDTILDAAEKGLAVFLTAGDTMVSTTHADLRIRAAERGIQTRIIHAASIASAVCG
LSGLQNYRFGKSCSLPFPHGKWMPTTPVEVILDNLSRNLHTIVYLDIQDTRYMLIPDAIP
IIEEIISRMGRSIPLYVGIARAGSDDMAIHAGSGADLLSHEFGPPLHILLVPAELHHMER
EYLETFAGLPQVRGQQP
>A0A1D8S4H8|diphthine synthase|EC 2.1.1.98|Halodesulfurarchaeum formicicum|TrEMBL
MLTFVGLGLYDERSVTIEGRDAIRDAEAVFAEFYTSRLVAATVEDLEAYHDVTIQVRDRA
GVEQDPEPILEAAETGPAVFLTAGDPTVSTTHVDLRLRAHDRDIETRIVHAPTAQTAASG
LTGLQNYRFGKSTTIPFPWAHGADGVPDSVIETIEANRERGLHTLAYLDIKAGSAELMDG
ATAAELLTEHWNGDVLGVVVGRAGSPEPTVKAASLEALSELSFGPPPHMLLIPGDLHPIE
VDALAAFGDAPKDQLE
>A0A554NDZ5|diphthine synthase|EC 2.1.1.98|Haloglomus irregulare|TrEMBL
MLTFVGLGLWDERSVTVEGRDAVRAADRVFAEFYTSKLAGTTVADLEEHHDVDVEVRARE
GVERDPGPVLDAAESGDAVFLTAGDTMIATTHVDLRLRAHERGIETSIVHGTTAAAAAAS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVLETVDANRERGLHTLCFLDIKVGHERAETD
EHMTASTAASLLTEAGRGDDLGAVVARAGSPDPVVVADRLTALAEREVGDPLHLLVLPGG
LHHIERDALVELADAPPALADERLA
>A0A7C5F852|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MGKIYFIGLGLFDEKDISLKGLEAVRSCERVFAEFYTAFLAGTSKEKLESLYGKNIKILS
REEVETGNEIIESAKSCNVAFLTAGDAMTATTHQEIRLRAFDLGIETEIIHGASIVTSAS
GLLGLQHYKFGKTTTIPFKQKGYFPTSPYDAIRDNLKIGLHTLVLLDIQVSKDSARYLSA
NEGLRYLLEIEESKKEGVAAKDRLVCVVSRAGSRMPLVKAGRLGEMIEEDFGQPLHSIVV
PGKLHFLEAESLIKIAGAPKDVLE
>A0A327GUT2|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MCRASGPSFTMTALSPLDLLLEGGACLTSMDVKLSGSGLILIGLGPGDLGLMTKHAIDAA
RDADFRFLEGYTATLPSDQENRLTEFLGEWTMMMRPDVENPTKLLDLAEHSSVALLVVGD
PMHATTHVDLLLRAKDRGIPTLVIPGISATSLAVTRSGLQSYRFGRQITLPYSYGDYLPT
SPLALLFNNLSNNLHTLVLLDLDPTGMGVKTPVPMSPRQAVEILGRMHERMDDNDNTSLP
SDTAILEWEAILLSDLGTPDQSLYSGSLKDIARVQSGRIHCMIIPAGMDEMERAAFERYR
I
>A0A7C2TPJ9|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
EALEKIRNSDEVYLELYTSRIVDMSLEELENFLNRKIILLDRKTVESNFLVERSRNLDVS
LLVPGDPIIATTHIGLVILSIENGIKYEIINGISVQCVVPSILGLQNYKFGRSISIPFPE
YDYYPESVYNFLLENRRLGLHTLVYLDLREGLEMSAIMGLDILLKMEDIHRKNALDRNTV
VAVISRAGSDRQRATADTVERIKTRDLGPTPHIMVIAGTLHYMEIEALRKLASFPDDQNV
NL
>A0A2Z2HNZ6|diphthine synthase|EC 2.1.1.98|Natrarchaeobaculum aegyptiacum|TrEMBL
MLTFIGLGLYDERSITVAGQEALRNADRAYAEFYTSRLIGTTVADLEAHHGIEIEVRDRA
GVEQHPDDILEAAETEDVAFLTAGDTMISTTHVDLRLRAHERGIDTRVIHGVTAQTATSA
LTGLQNYRFGTATTVPFPYAHGADGLPASVTDTIDANRADGLHTVVYLDIKVGHERTEED
EYMTADVGATLLAEAYPDLVGVVVARAGSPDPLVVAGTMTELAERDFGDPLHLLVIPGEC
HLLEADALVELGGADRDALDIA
>A0A7J4GR28|diphthine synthase|EC 2.1.1.98|Marine Group III euryarchaeote|TrEMBL
MLTLIGLGLGGPNSITMDGVIALSLSDHIFYETYTSPIHSETLEWVKLKSQKDPIHLSRS
QVEEPTEIIDLAKEKNISLLIVGDALSATTHVSLLLECKKLNIEYQVIHNASVLTAVAGA
LGLQHYNFGPVTTLVLPEGNYKPSSPIDKIKVNMKNGNHTLVLLDIKADQPDMDPIYMTA
SQAAWQLIEAKLSGEIKVAAAARVGRENQKLWYGKIKDLAKTDLGKEPHSLVVPSKLHFT
EREFLESL
>A0A0E3LCR2|diphthine synthase|EC 2.1.1.98|Methanosarcina siciliae C2J|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVREADLVYAEFYTSCLMGTNPEKMEKLYGKKVHLLFRE
DVEQQPTWLDEAKDKNVVFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGL
TGLQNYRFGKSASIPYPYESRRGARIISETPYDTIKKNSELGLHTMVFLDIDKDKGYMTV
NHALELLLEVENRRGEGIMDRAVAVGIARAGSEKPVVKADYAENLKGFDFGKPLHILVVP
GKLHFLEAEALVKLASGPEEIMEETE
>A0A5Q0SHZ4|diphthine synthase|EC 2.1.1.98|Sulfolobus sp. E5-1-F|TrEMBL
MSVLSLIGLGISKKFITESAINALNDSDIIIFDKYTSRSCDINVDILRRLVKGEKTFIEA
DRSLLENNSKIIMDYLDKTYNVSIASIGDVLIATTHVSLLVEAKQRGHKVKVIPGISVHC
YLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIEDNRKRGLHTILYLDLKDEKAMTAN
EALQILLRLEEKHRKNVLSKSDIVIVGARLGCDNEKIIALTVEEAISYDFGNTPHIIIIP
GNLHYMEAEAIKWILMS
>A0A497I2Y9|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
ALELLEEVERRRERAGKEAGILKEVLFVGVARAGSETQVVKADYADALKRFDFGEPPHVL
VALGELHFMEKEALVRLASAPL
>A0A7J4JDS6|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLTLIGLGLDWKDLSLKALEVLNKCDEVYLENYTSLSNYTILQLEKLIGKKIKVLGRKQT
EEEMPFLKEAHLKDVALLIYGDPLSATTHFEILEIAKKKKVETKIIHAPSIFTAIAETGL
SLYKFGKVASIPIPEKNFAPESFFDILKENLLIGAHTLFLLDLKPDLNKFLSIKDAIDIL
LKINLKRKENSFTENTFVIGCARLGTTDSLIKCGKAKDILKINFGEPPYCLIVPANLNHK
EEEYLKII
>A0A7J4JDX2|diphthine synthase|EC 2.1.1.98|Candidatus Diapherotrites archaeon|TrEMBL
MFYLVGIGLKPGHLTLEALEAVKKCRHVLLENYTSRYAEGSVKALEKALGVEVFEVSRRE
VEEGFDKILSRAKREHTALLVYGNPLIATTHVQLLLDARAQGVDCRVIPGVSVTDFLAKT
GLDAYKFGRTTTLVFPQENYAPESFYDVIAKNKGLGLHTLCLLDIQAEKAHAQRLMTAKE
AIRILLAIDQKRCTQLFPKSTKLIALCALGSDQELIAAGRAERLLDFALEGMPQCLIVCG
TLNEKEEEAVKALCES
>A0A842LY95|diphthine synthase|EC 2.1.1.98|Archaeoglobi archaeon|TrEMBL
MLVFVGMGIYDERDISLKGLEAVKRADAVYAELYTHKGSFSIERLSKFFGREVKELKRED
LEERAERILEEAREKNVVLLSGGDAMVSTTHADLMIRARRMGIQTKIIHASSIISAIPGI
TGLQNYRFGKSATVVYPYFIGGRRILPETPYDVILQNLRNDAHTLLFLDIRERCMTIPEA
VEILLEIDERRERILRGRIAIGVARAGSDDCTVAADRIEKLVRKDFGEPPHSLVIPASLH
VIEEEYIKEVIGGFKE
>M0LII4|diphthine synthase|EC 2.1.1.98|Haloarcula japonica (strain ATCC 49778 / DSM 6131 / JCM 7785 / NBRC 101032 / NCIMB 13157 / TR-1)|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRDADRVFAEFYTSRLIGTDIETLEDTLGTSIEVRDRA
GIEQDPEPILEAAERENVVFCTAGDTMVSTTHTDLRLRAEDRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNQDRDLHTLVYLDIKVDDPHWDDS
DDTYMTASQAAAMLSGPFPDTLGVVVARAGSPDPLVVADTLDELATQTFGEPLHLLVIPG
SLHPLEADVLESLAGAAVE
>A0A371KTS7|diphthine synthase|EC 2.1.1.98|Haloferax sp. Atlit-24N|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7D5BTR8|diphthine synthase|EC 2.1.1.98|Halorubrum sp. CBA1229|TrEMBL
MLTFIGLGLYDERSVTVEGREALRDADRVFAEFYTSRLVGADVDELEAYHDAEIEVRARE
GVEQDPEPILAAAAEGDVVFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADAAAGLLAEGWRDELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVV
PGDLHHVEADALAGLAGAPRELVEE
>M0KZD1|diphthine synthase|EC 2.1.1.98|Haloarcula californiae ATCC 33799|TrEMBL
MLTFVGLGLYDERSVTVAGRDAIRGADRVFAEFYTSRLIGTDIETLEDTLETSIERRDRA
GIEQDPEPILEAAESEHVVFCTAGDTMVSTTHADLRLRAADRGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTLPFEDAHGGDGVPDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEDS
DDTYMTASQAATMLSEPFPDTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPG
SLHPLEADTLESVAGAALE
>A0A847V901|diphthine synthase|EC 2.1.1.98|Methanospirillum sp|TrEMBL
MLVFVGLGLWDLEDVSLRGRRAIAEADRVFLEGYTSRLVGASVAEMEAAWKKPVTVLSRA
GVENRPDEVLAAAREGTAVLLVPGDPMVSTTHVDLRLRASRLGIETRIVHGASIATAAAG
LAGLQNYRFGPATSLPFPHGNWRPTSPVAVIGENLSRGLHTLVYLDIQPGRFMLIPDALD
LLGTTAASLGQEIPLYVGCSRVGSPDPVVAAGDAARLRAVEFGGPLHVLIVPGDLHVMER
EHLEAFAGL
>A0A6B2C9H9|diphthine synthase|EC 2.1.1.98|Desulfurococcales archaeon|TrEMBL
MSSKDRCVKLYIIGLGLYLKQITLEALEILRDRCEKIFAEEYTSISSRGGIEDLEKIIGK
KIIRVSRKDLEDLNGEILLKNLRENVNTCLITWGDPMTATTHVSIAKRAVEEGFCIRYVP
GISSIHAALGFTGLMIYRLGKISTITFPKDNILSEYPYHVLRENMIRGLHTLYLLDIDVE
KNIFMRTSDAVRILLELEERFRENLFNEKSFVLGIHIDEDTIICGGEAKFMLKDPLKEVP
QILIVPSKLFVTEDEYIRSLGLKYDRCITIS
>A0A662UUF0|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MGKLYLVGIGLTSDLISLRALNVIRRARKVFIDAYTGIVLDGDLADVIGVKPARLSRADI
EDRNAEVLFNELERGDVALLVPGDPLVATTHIALAVEAFKRGHDIEVVPGISIIPNALTI
SGLMIYKMGKVVTVTYPSQGLLYEYPYDVIRDNDSRNLHTVLLLDIDVERGVMMTVRDAI
NILLEIELRRGEKVIRPERLVVAVAALGSRELMRVCALRVSEAKRFKYPHGPQTLIITSP
KLHYMEEEALRVVNSVYCREL
>A0A833DP84|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDEKDMTLKTLEYAKRADKIYAEFYTAALTGTTLNKIEEVIGKKITLLSRE
DVECRSDKLIEESRNKTVMFLTAGDPMVATTHVDLVIEAKKRGIDVRIINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYYVIRDNLRMGLHTLCLLDVDSDKNRFMSANEGL
KILLEIENRRRENILNENTKVVVLARAGSFKPKIVYGKIKDLIDYDFGPPLHSIIIPGKL
HFMEEEALKYLCENIS
>A0A833EAY5|diphthine synthase|EC 2.1.1.98|Methanothermococcus okinawensis|TrEMBL
MLILAGLGLYDEKDMTLKTLEHAKRADKIYAEFYTSLLTGTTVERIEEVIGKKITLLTRE
DLEYRGYRLIEEGRDKVVMLLTAGDPMVATTHVDLAIEAKKRGVDVRIINAPSIYSAVGI
TGLQIYKFGRTASIVFPEPNYFPETPYNVIRDNLRMGLHTLCLLDIQSDKNRFMSANEGL
RILLEIEERRKENVLSEDTKVVVLARAGSLKPKIVYGKIGDLLDYDFGPPLHSIIIPGKL
HFMEEEALKYLCENVP
>A0A662H1Z9|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLYFVGLGLSSKDISLKALDVLKRADRIYVDNYTSLFMNSDFKVVLSEYVDQAKVSFVDR
EFLEGEDYRRILKEAALRDIVIAVIGDPFIATTHIFIRIEAEKAGIPTKVIHAPSILSAG
ISATGLQAYKFGKSATIVFPEEEFFSTYPYEVLYDNLLRGLHTFFFLDIKVERSRLMRVE
DALKLLLRMEEFENKGIIDLGALGIGLGRIGSDNE
>A0A3M0WDT6|diphthine synthase|EC 2.1.1.98|Candidatus Pacearchaeota archaeon|TrEMBL
MAFYLVGLGLWLDSVSNGALNALKKCEKVYLDGYTVKFPYSLDELRRSLGLDFELRGREQ
IEDESIVLEAREKDVALMVYGDPLFATTHYQLLVSCNEAGVKRRVFHNASVLDAVSLAGL
SLYKFGKVTSVPDWRKHTNCPTSFVDYILDNQKVQAHSLVLFDIGLEFERAVEQIEQAFE
KKGFKIREAVLIFCAGTPKERVFYGEFEGLKNVRVEEPYCIVIPANLNDFEKRALEEFKV
Q
>A0A5E4K7L5|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MITFIGLGLYDEKDDTNKGLEAIRQDDVVYAEFYTSHLVGTTIEKMEEFYERKLTVLTRE
DVEQNPSWLSEAKEKNVAFLSGGDAMVATTHIDLRLRAVDMGIGTAIIHAPSISSAVSGL
SGLQNYRFGKSTTIPFPYTRRDKTVVSEAPYDTIKMNKRNDLHTLVFLDIDREKGFMEIG
KAIEVLLEMEERRGEGVLLNTLAVGIARAGSDSPAVHSDYLEGLKEYDFGAPLHVLIIPA
SLHFIEAEALVKLCGAPPEIMK
>A0A843D0A3|diphthine synthase|EC 2.1.1.98|Methanocorpusculaceae archaeon|TrEMBL
MLTFIGLGLFDEYDVSVRGLDAIRNADTVFLEVYTSVLMGSSIERLEEYYGKKITPLYRE
DVEIHSDKIINAAKEGDAVFLTAGDSMVATTHSDIRCRCAEAGVETKIIHGASITTAVCG
LSGLQNYRFGKSVSVPFPYGKWFPMTPIEVISENLKNNLHTLVFLDIQKDKERYMKVSEA
VELLEEQARRVGAKIPVYIGIARAGSPAPVVHAGDAEEMMQFDFGGPLHIMVVPAELHDM
EREYLERFAGLC
>A0A063ZNF7|diphthine synthase|EC 2.1.1.98|Halostagnicola sp. A56|TrEMBL
MLTFIGLGLYDERSITVEGRAALRDADRVFAEFYTSALLGATVEELEDYHDVTIEIRDRA
GVEQHPEEILEAAETESVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGITAQTATSA
LTGLQNYRFGTATTLPFPYAHGADGLPASVTNTIDANREAGSHTVVYLDIKVDNEAALER
VDTDEAVAEYMTADIGAGLLAEAYPDLVGVAVARAGSPDPLVEAGTMTELAAQDFGDPLH
LLVIPGECHLLEADALVELAGADRDALDIV
>A0A2R6MNG2|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_8_68_21|TrEMBL
MLTFIGLGLYDERSITVEGREALRESDRAFAEFYTSRLVGADVADLESHHGVEIEVRDRA
GVERDPEPILDAAESGDVAFLTAGDTMISTTHADLR
>A0A1Q6Z757|diphthine synthase|EC 2.1.1.98|archaeon 13_2_20CM_2_53_6|TrEMBL
MDSFAFIGLGLNDEKGLTLEGLEEARRADRVFAEFYTNPMPALDMKRLEKLIGKKIHVLN
RTQLEEEGGRELIRSAKEDSVAFLVPGDPMIATTHISLRLSLSKAGIGSRIIHGPSIMSA
VCGATGLQSYKFSKTVTVPYDPPLPASILETISDNYGRGLHTLLLLDVEADLNKQLTIAD
ALAKITSANPSLETRLAVGVARLGSRDEKVKASRIGRLVTEDFGGPPHSIVVVGRPHFME
TEALRIICGAQDSDLRENS
>A0A3R7TLV5|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED99|TrEMBL
MTLAPSKRVGGLRMAEDSVQLVTLPKTGLLLIGMGPGTVAGMTLEAIEAAKKASHRRYEA
YTALWPESELNALEQRIGPIQKVMRPEVEQPDELFQLAKTSLVALLVVGDPLQATTHVDL
QLQAIEHGIECRVFHGVSITTIVTGAVGLSNYRFGRQTTLTYPYGGWIATSPLEMIAVNK
ARGLHSLVLFDLDPTGQGTGDQKPMSPRDAKRSIELMWDKLDEHLKQFTNPPDKTLIAVQ
EAMFKVLLDEXRNELPVVLCSDMGTQDQKITFTNIGGLENLEGGRLNCLLIPAWTSEVEE
MALLRWKEE
>A0A7J4UR57|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MTLYLIGIGLENEKDISVKGLDIVKKCDVVYLERYTSLLQCSAHDLAKFYGKEIVLADRT
TSEQGDHTIVAEAKDKDVAFLVIGDPFSATTHIDLFKLAKEENVAVEVVHNASILNAIGI
VGLQLYKYGKTTSIPYLDDHPNLETPYRIVQQNKRIGAHTLLLLDIQTHKDRFMSVTEAI
VVLEDIEKRVGEKVITDDLRVVGCARLGTADFMVKAGPLSEMKKIDFGKPPHCLIIPGKM
HFIEEEMLELWR
>A0A7K4C8T7|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MFYLIGLGLDEKDLTNESLKVLKKSSIIYLEDYTVNFPYNLEKFIKNLEKKIKKRIIKAN
REKVEDLSLIKESENKDVSLLVYGSPLTATTHISLIQEAKKQKIKFKIFYNSSIFDAIAE
TGLEIYKFGKITSIPRWQSNFKPKSFAEIIKENLSVNAHSLLLIDINLDLNDAIKELKEG
LSEYNIKIYNDKIVLCSCLGTEKSKIFYADIENIIKLNSELNNKLNIEKPYCLIIPGKLH
FLEKEILEGFEI
>A0A2H9QIC6|diphthine synthase|EC 2.1.1.98|archaeon CG_4_10_14_0_2_um_filter_Archaea_38_6|TrEMBL
MFYLIGAGINDYADMPLKGLEYCKKCSFVFLEKYTSIFSDESVKKL
>A0A101DYB6|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon 55_53|TrEMBL
MLTFVGLGLFDEHDITLKGLRAVQQADEVYAEFYTSRLCGASIEQLEALYGKKVHVLSRE
DIEGHPTFIERARELDVVLLSGGDPMVSTTHVDLRLRAHRMGIATRIVHAPSIVSAVCGL
TGLQNYRFGRSATVPFPYEHGERRMVYESPYDVVRENLERNLHTLLYMDIQNGRFMRASE
GAALLLEVAQRRGDEGLSSRLGVAIARAGSEDCVVRAAPLEDIASMELGPPLHVLVVPAE
LHFMEAEALVEFAKAPRHILEG
>M0AEA3|diphthine synthase|EC 2.1.1.98|Natrialba chahannaoensis JCM 10990|TrEMBL
MLTFIGLGLYNERSITVEGQEALRNADRAYAEFYTSTLIGTTVERLEDAHGIDIEVRDRA
GVEQHPDDILAAAETEAVAFLTAGDTMISTTHVDLRLRAHERGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDENRENGVHTVVYLDIKVDNEAATNR
LEGDDTVEEYMTADVGAELLAEEYPNLVGVVVARAGSPDPLVEAGTMSELADREFGEPLH
LLVVPGDCHLLEADALVELAGADRDTLDIV
>A0A1H7JGK2|diphthine synthase|EC 2.1.1.98|Methanobrevibacter gottschalkii|TrEMBL
MFYLVGLGLFDEKDISLKGLECLRNVDKIYAEFFTSRLFGSNFNAIEELVGQKIEILVRG
EVEEESKFIEEAKTQDVALIMGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSILSSAPAI
SGLQGYKFGKVTTIPFPDYNFYPKSPYEAIEENLKMDLHTLVLLDIQAHKDRYMTVNQGL
EYLMNIHDTLDRDGLINENTLAVGIARVGSKDVCVKAGTINELIDFDFGGPLHCIVVPSK
LHIVEAEYLVEIAGANSKLLDIV
>A0A7D5H1S7|diphthine synthase|EC 2.1.1.98|Halobaculum halophilum|TrEMBL
MLTFIGLGLYDERSVTVEGQDALRAADRVFAEFYTSRLVGATVGELEAYHAVDVEVRDRA
GVEQHPEPILDAAESSDVAFLTAGDTMISTTHVDLRMRAVERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKAVTLPFPYAHGADGVPASVVDAIEDNRERGLHTLVYLDIKVAGSSPAGP
AEGEPDEFMTASEAAGMLAEDWDSEVLGVAVARAGSPDPVVAADTLAALAERDFGAPLHM
LVVPGDVHHLEAEALATLAGCPAGVLPEF
>A0A2H9LZR4|diphthine synthase|EC 2.1.1.98|archaeon CG06_land_8_20_14_3_00_37_11|TrEMBL
MFYLIGAGINDYADMPLKGLEYCKKCSFVFLEKYTSIFSDESVKKLEELIGKKIIIVGRE
DLENDFEILILEKAVKNDAALIVAGDPLAATTHIEFLRSCKERGVDYKVVHASSIYSGVC
ETGLHVYKFGKSCSIPFPEPNFNPTSFFDVITENHNIGAHTLVFLDIKQDLKKYMTINEG
LKILLKISKDKGGFFDEDCEVIGIARLGSDNQVIKCGSVKELLNFDFSANPHVLIIPCMN
DIEREYVANLYL
>C7P5Q4|diphthine synthase|EC 2.1.1.98|Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)|TrEMBL
MLILAGLGLYDENDMTLKTLKFAKKADKIYAEFYTAVLTGTTIEKIEEVLGKKIHVLSRK
EVEYDGYKLIEEAKDKDIMFLTAGDPMVATTHVDLAIEAKKKGVEVLIINAPSIYSAVGI
TGLQLYKFGRTASIVFPEENYFPETPYNIIKENLERGLHTLCLLDIRVDENEKRFMTANE
GLKVLLELENRKKENVISEDTKAVVVARAGSLKPKLVYGKIKYLINYDFGKPLHCIIIPG
KLHFMEEDALKYLCENI
>A0A662MEC6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MGILYLIGLGLCNEKDLTLRGLEILRNKVKEVYIELYTAVPRKLNVDSLKELIGKDVKVL
RRDAVESNYLLDRAKKTDVALIVPGDPLIATTHISLILEARKRGIAYRVVHNASVLTAVP
GACGLHAYKFGRTTTLPYPYKGHIFESPYDVIKENLSRGLHTLILLDLDPQKGSSMSVRE
GIEILMKIEERRKEGVIRDDSILVGLSNIGSDDEIVKAGYPKDLMRYKFPMGMHSIVVVG
NLHFTEAEALVYLADAPKEILKNV
>A0A662L2M9|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MPGELIFIGAGLSRDDISLKALSAAKSCDVIFAEEYTSRLSDCSMKELETIIGKKISVLR
REEVEEEEIPIRHALTKKVAFVVAGDPMTATTHISLRVEAEKKGIKTRVIPGVSVYTAVP
SILGLQHYKFGRTTTLVYPEENFFPLSPYYVIKENMERGLHTLVLLDINAERNRLMTLGE
AIDILLEMENRAKEDVIKEDLLACAVARAGAGDSIAIAGTIKRLREEDLGKPPHTMVIPG
ELHFAEKEALKILCGYREM
>A0A830F5H1|diphthine synthase|EC 2.1.1.98|Halarchaeum grantii|TrEMBL
MRTKRARTALPLAFARERNETRIRAADPVTRMLTFVGLGLYDESSVTVEGRDAIAAADRA
FAEFYTSHLVGADVSDLEAYHDTDIEVRDRAGVEQHPERILDAAEAGDAVFLTAGDTMIS
TTHVDLRLRAHERGIETRVIHAPTAESAASSLTGLQNYRFGKATTLPFEWAHGADVVPDS
VIATLEDNRERGLHTLCYLDIKVGRGPEGEDPDFEEYMSADYAAGLLAEAWDPDALGVVV
ARAGSPDPVVRADRLDRLADESFGAPLHMLVVPGDLHHVEADALAGLAGAPDDLLPE
>A0A1D2WSV7|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp. A54|TrEMBL
MFLKSYTMFYLVGLGLFDAGDISLKGLKCLKSVDKIYAEFFTSRLFGSSFDEIESQIGKK
IEVLVRNEVEEESKFLDEAIDLDVALITGGDPLIATTHSDFLVQCSKKGIDYEVIHGSSI
LSSAPAISGLQGYKFGKVTTIPFPDHNFYPKSPYTAIEENLAMELHTLVLLDIQAHKDRY
MTVNQGLEYLMNIKNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLH
CIVIPSKLHIVEAEYLVEIAGADSEILDEI
>A0A1J4XU44|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon CG1_02_47_18|TrEMBL
MSLTLIGLGLCDYNDISLRGLEALKQADVVYFENFTNILACSIKEMEKAYGRMITPVKRE
FLEPGEGLIAEAQSRRVALLVIGDPLTATTHISLFLRAKEKGVAVEVIHNASVMSAVAIT
GLQPYKFGMTSSLPFPGSSFKPETAYEVIKRNKASGMHTLLLLDLKPDEGRFMGIGEAID
ILLSIEEKRLDGVFATNTPCIGCARLGWPDCRIICGKASELRKADFGKPPHCLVVPGSLH
FVEEEAIGGYRLNHS
>A0A522Y0P8|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotenuis sp|TrEMBL
MLWFVGLGIGGPDSLSDKTKKIISDADVVYFEQFTSPMKNDESQRIKELTKGEFKFAPRW
LVEDGKEILDSAKTKNVVMVSYGDPYIATTHIELRTRAIQEKIQTDTVHASSAITSLVGE
CGLHYYKIGRTVTIMSGIPSSTAYYTIYENLKVGNHTVILLEYNQNEDFFLNPKSAIESL
LESEKEQVRKVISDATYGIVASRIGQQDQKITAGSFASLKKTDFGNPPHTVIIPGTLHFT
ESDALKVLARCIDEPNDNSSKIERIASQMMKRYVPMVRRALEQITPHYKDAKEFHSVLEN
AELYIRDAEIFFEQGKDELAILSIGYADGLVDALRIAKGIEPETSS
>A0A7J9Q8P4|diphthine synthase|EC 2.1.1.98|Nitrosopumilaceae archaeon|TrEMBL
MLSFVGLGISGFESIPIEGLETISTADIVYLEQFTSPISESDLKKIQDSIKGEFKLAKRW
LVEDGNEILEMSKEKNVVLLAYGDPYIATTHIELRARAIENKIKTHSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNLIEGNHTVLLLEYNQDKKFFLDPKDALKG
LLETEQGQTRNVITESNYVIIASRIGFKDQAIICGKISNLKETDFGKPPHTIIIPGRLHF
TESDALKLFGKCIDEPFDNSEKTEKISNQMMKKYVPMVREALEEIEPLYKNQKEFEVILD
NAERYIKDAEIFLGEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A497G3J5|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MLYFVGLGLHGCEDLTLKAVRVLRKCCEIYIDVYTSIVPEFSKDILLKIIGSETKIICVH
RRELEDDTFVSRIIEKSRKMDIAILVPGDPFIATTHLWIRIEAERSGVKTRVIHSSSILT
AAISETGLHVYKFGRSTTVVYPEDGYIPYSVYETIFENLSRGLHTFLFLDLKIDQGKVMS
ISEAINVLELLEKHLSKKIIGPYTLGIALARLGSPDSFIIADTFSSLKEKDIGPPPYSLI
IPGDLHFTEEEALVVLAKAPQEAVKKWKKIVRDLKNTLSR
>A0A7C4HUB4|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MLVFVGLGYSTRHLTLEAVEELKSADVIYIDVYTSIYEDPLTKIIELNPDAEVIIARRKD
LEGASAREVIEKARRGKVVIAVPGDPFIATTHDAVLADALRQGIEVRIVNGISIVTMAFS
RLGLQSYRFGKHVTLVYPTHFRPYSSIEVIYDNLKRGLHTLVLLDLRVEERKAMTIQEAV
DVLLELDYLNVLKDQLALGVARLGWRDEKVCVDVLPGLKLKKFPPPPHSVVVLARLDPVE
EELIKYWKEC
>A0A537HIF4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MVVTFIGLGLNDERGLTIEGLEEARRSSDVFAEFYTNIMPGLDRKKLELLLGKRIVELSR
VQLEDEGGKQIVEAVERGRVAFLVPGDPMIATTHVSIRLELAKKGIPSRIIHGPSITSAV
CGATGLQSYKFGKSVTLPHESGVPGSVLDTLHDNGKRGLHTLMLLDVRPEQSKQLTIREA
AAKLVVADPGLQRSLGVGVARIGSDDQFVLSRRLETLQHQEFGRVPHSLVVPGKLHFMEA
ESLKAFCGASDEDLESLK
>A0A832FZ90|diphthine synthase|EC 2.1.1.98|Aeropyrum sp|TrEMBL
MTLILAGCGLHPGSFTRDLLEALEDADTIYVETYTMPSSSWVLHALNKWISKVRITSRKL
VEENSRLLIEEAKSRLIVVLSTGDPLIATTHQALLAEAISAGVEVRYIPGVSGVCIAKAF
SGLQYYRFGRTTTIPGPWRGFKPYSILAFIYGNLCIDLHTLLLLDISDDGTQLKPQEGAR
TIIEVEVEAESAIGYKGTLRNTPALVLEATGTPQGKIIPFNSLEELMSSNLHIREPSSIA
IPAPLNKTEKWILEALSRSKLGEIWLTRTQPRRYYCDLYEKIIGWLSSPLYSL
>A0A662TLS9|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MITIIGFGIRPKHMSLEALEVLKRADKVFLEAYTNVFPSSFVEELKRIIGTDDITLLKRE
ALENNLDKFIEESRSKHVALLIQGDPMFATTHINIILECKKKGIPCKVLSGISIYNRILA
VTGLQPYRFGRLVSIPLLSKNFMPSSPYLKIAENMRSNLHTLVLLEAVSDTEFLSINDAI
DYLLKMESRFRMKVISDNRFAIGVARLDYDEGIIKCDKVLRLREIEFGSPPHALILLADC
LHFLEAEALIELLSAPIEVKRLVK
>A0A1D2R0I0|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon WOR_SM1_SCG|TrEMBL
MLYIIGLGLYDEKDITLRGMQALKNCKKIYAEFYTNLWHGNIENLEKMSGNKIKILNRGI
IEETPEEFLNFAKTEDTALLIPGDPLAATTHIDLVLRAEKQGIPVKIIHSSSIFSAVGET
GMQIYKFGKTTSIVFPEKNYFPESPYDALCSNLKMNLHTLFLLDVKYDESRYMTVNNGIE
ILLQIEKKRAAGIFTEKTLCVGCARLGGEEEIKYGTAKELMRHDFGAPPHALIVPAKLHF
VEEEALLRYKIQ
>A0A830GMT8|diphthine synthase|EC 2.1.1.98|Halomicroarcula pellucida|TrEMBL
MLTFVGLGLYDERSVTIAGRDAIRDADRVFAEFYTSRLIGTDLESLEAYHDTTIEVRDRA
GVEQDPAPVLDAAETDDVVFLTAGDTMVSTTHTDLRLRAEERGIETRVVHGTTAQTAAAS
LTGLQNYRFGKATTLPFERAHGGDGVPDSVVQTIEDNRSRNLHTLVYLDIKVDDPHWDDS
DDTYMTADHAAGLLAESFPETLGVVVARAGSPDPTIVADTLDELATRSFGDPLHLLVIPA
DRHLIEEDALTAIADAP
>A0A520K0X1|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
MLTFVGLGLYDEEDISLKGVRAIKDADMVFAEFYTSKMMGTTIKRMESLYQKKVTVLSRN
EIEIDPTWLHHAINEEVVLLTGGDPMVSTTHVDLRLRASDLGIKTAIIHGSSIASAIAGL
TGLQNYRFGKSATIPFPYHSRSKTIISETPYNVILQNRDSDLHTLLFLDIDPAQGFMTIP
HAARLLMQVDESNALEAALGVGIARAGSPDVMVHCDRLISLATSDFGAPMHVLIIPATLH
RMEAEALVRFAGAPDDVLD
>A0A497IX34|diphthine synthase|EC 2.1.1.98|Methanosarcinales archaeon|TrEMBL
LRLRAIELGIETRVIHAPSILSAAPGICGLQSYKFGKSATVAPPYKGRIPETPYDTLMLN
RKHGLHTLLLLDISMTVRDAIELLFSIESQKRQRGEATSDIERILFVGIARAGAEKPIVR
ADLPQKLKEYDFGAPPHTLIAVGSLHFIEKEALIKLAGASSEIF
>A0A533VUV7|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon|TrEMBL
MGRLTFVGLGLGARGISLEGVVAVREADSCYLEYYTTPHEPTLLKELENETGRIMTVVDR
EFVEDGREILKEARDSKVVLVVPGDPMIATTHNELRVRAIGQRTETAIIHAATIPSSAAS
ASGLHYYKFGRMMTITRETLDFMQQAYHTIQSNLLQGLHTLLLLEFDVEAGEGATPQAVF
DGLLAAEKNFGREVLSEETFALVLSRLGRQDSELRAGSLRDLRNSDYGEKPHCIVIPGGL
HFTEVEAVAAIFGVGEAEVSDNSRNMKGTAEVLIPRYAAKTRRALNSAREKLGMEYDTLL
ENVELYTKDAEGFLARGEHELAMLSMGYAEGLLDSAGFTGRAKIDW
>A0A2J4G8D2|diphthine synthase|EC 2.1.1.98|Thermofilum sp. NZ13|TrEMBL
MLIVGGVGIWGLRDISLGLVEALKTAELVFLEEYTSITPGFSKRVLEDVIGKKVESLTRR
DLENGRLREILELAQTNKVAILTYGNPFFATTHTYIVSEAYRLGVPVEIYPAPSVFDAIL
CSTGLHVYKFGRIATLVFPDEGVGYFPYTTYKVLGDNLSRGLHTLLLLEMRAEDGVFMSI
PDAASVLLGLEERFRERVVEPSMLVIGVSRALSPDEEIFIGSLEEAAKLEKSPPPHSLII
PGVLHDTEIDFLHYRLGVKREVLTGWSESVKRRLQST
>A0A3A5HCH7|diphthine synthase|EC 2.1.1.98|Methanobacterium sp|TrEMBL
MLYFIGLGLYDEKDVSLKGLEALRNSDKIYVEFYTARLFGTTISSLEKIMDRKVEILSRE
QVEEEEIPLKNAETNKVAFLSAGDPLIATTHADMMIEAKKRGIKTRVIHSSSILSAAPGI
SGLQAYKFGKVTTIPFPEKNFFPHSPYLLIKNNLEQNAHTLVLLDIRAHEDRYMTVNQGL
DYLLKVEDTLNEGVITKNTLAIGLARAGSDEPVIRADIIKKLIKEDFGGPLHSLIIPAPL
HIVEAEYLVAVAGAPEDIINRI
>A0A7M3WSU7|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MPLIVTTGQDGISMTVDLPPTGLLLVGLGPGGRSGMTAAAIEAAQTADHRWYEAYTALWP
EQDVIDLEAHVGPIERVMRPDVEHPTEMFELARTSLVALLVVGDPLQATTHVDLQLRAED
AGVPCRVLHGLSITGMVTGAAGLSNYRFGRQTTLTYPHGAWIATSPLETIALNRHQGLHT
LVLLDLDPTGAGTGDQRPMRPEDAHRSLHMMAERLAERPPEEGALSSLTSADLEGLDVGA
WTVVLCADVGTSDEAFVTTTVDGLPSEVGGRLNCLLVPAAIEGVEAAAIARWRRS
>A0A833E5D0|diphthine synthase|EC 2.1.1.98|Candidatus Nanopusillus sp|TrEMBL
MFVLAGLGQKPEDIPIGTIKYIKKAGYVFLEYYTNVPNIRIERFLSKFRKDIKIVFRDFV
ETKLEKFLLEHKKDLVVLLVFGSPLFATTHTSLLSFCKEHKIKVRVIGASSVYDYLAKTG
LFIYKFGKTASISFHKSKVPYDILKYNYMIGAHTLFLLDIDPENRRYMTVNEALIRLLEL
EE
>A0A842Q8C0|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLNLIGLGLNNENSITLEGLELCRKSDKIYLETYTSKWNGSLEDLAKVVGKEIIKLERSD
LEENSDKILFEAKEKKISVLILGDPLVATTHTSLLLEAKKNGIETHIIHNASIYSTVSET
GLHLYKFGATVTIPFPEKISNETPKSIYKTIDGNIERGLHTLCLLDLISEENKFMSPKQG
IEILLGSDNISEERELVVFGRSGTEKPFIIYGKIKELLTEDFGDPPFVLILPESLHFTEQ
EYLSYYRVD
>A0A7J2U5A0|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MLRLIGLGLSIDTLHLGSLKRILSCDEIVVDGYTSVWFPSIHLLTSLLIQLGKKVVIASR
NNLEGGAAKSLINKALDKEVCILVAGDPLIATTHSSIITEALTSHVEVEVMPATSVYNAA
ISLSCLQVYRFGKVATVVSPKNGIIYEYPFNVIKMNRSQNLHTLLLLEIDIEKNYYMKPH
EAIGVLLRIQERLAENVISLKDIVIILSDIMSCKQRIWIVPVEEVLKMQSEFQHNILYTI
IIPSKDLHPVEEECLNLMKKSRINHQCMVCEEDLKKVLQIFSTQ
>A0A7C2ZV60|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MGQSRRGTKIEGFAILIKLIGLGLSIDSLSLGAILRLLACRKVYIDTYTSIWYPSIDIIA
RILSRLGIDVVNARRSDLEGNAIVNIVREALDDVICIAVPGDPMIATTHSAIVVEAFARG
VEVELVPSTSILNAAISISCLQAYRFGKMVTIVKPKDGIVYETPYNVLKSNRDQGLHTVA
LLEIDTEKNYYMTPKEALEILIDIEKKRGEKVLEEKDIVIVLESIGFETGKIICGTVKEL
VERRYGKALYTLIIPARKLHPVEEECIQNITKLKVFKPIANDAVLELLIEAVAQRLKHKA
>A0A256YSA3|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon ex4484_224|TrEMBL
MIVLVGLGLYDERDVSLKGLEEIKSSDKVYCELYTSFWNGSLENLEKLANKKIILVKRKD
LEDSLEKIVEEAKDKKISILVPGDPLVATTHSSIIQEARKRKIKTKIIHSSSIVSAIAET
GLHIYKFGKVVSIPFLEKVSELPKSVYDSILSNKKNNLHTLCLLDIDFENRRYMSVKEAL
EILLKINEKYGGEILNEEEKILVVCRLGSENPKIVYGKIKNLIKKEFGYPCSLILLSPLH
FSEKEFIELFAEE
>A0A482XXW9|diphthine synthase|EC 2.1.1.98|Natrinema altunense|TrEMBL
MLTFIGLGLYDERSITVEGRDALQAADRVYAEFYTSKLIGTTIDDLESYHDIEIEVRDRA
GVEQHPDDMLEAAEREDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKTEREEYMTA
DTGATLLAEEYPDLVGVVVARAGSPDPLVEAGTMSELTNRDFGEPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A7K4DT81|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLWFVGIGVSGFKSIPIEALDVLSKADIVYLEQFTSPIGKSDLRKIKDSTKAEFKEAKRW
LVEDGNEILKNAKKKKVALLSYGDPYIATTHIELRTRAIDEKIKTFSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTILLLEYNQDKDFFLEPNVALHG
LLETEKGQMRKVVDLSTFVIVASRIGFRDQAIISGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKILGECIDEPFDNSEKTQKISSQMMKKYVPMIRDALEEVRPRYKDQKEFHIILE
NAELYIKDAEKFLEEGQDEVAILSIGYADGLIDALRLAKGLDPKM
>A0A075I4B9|diphthine synthase|EC 2.1.1.98|uncultured marine thaumarchaeote SAT1000_10_F12|TrEMBL
MLWFVGLGISGTKSIPIEVEKIIQEADFVYLEAFTSPISQIREDKIKNTVNGGFKIAKRW
LVEDGQEILKTAKSSTVVLLSYGDPYIATTHIELRTRAKLERLKQRQFILLQL
>A0A081RM48|diphthine synthase|EC 2.1.1.98|Marine Group I thaumarchaeote SCGC AAA799-N04|TrEMBL
SRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHFTESDALKVLGECIDEPFDNATK
TRKISAQMIEKYVPMVREALEEVEPYYKDQKEYQVILENAELYVRDAEKFLEDGQDEVAI
LSIGYADGLVDALRLAKGLDPKM
>A0A2A2HXU0|diphthine synthase|EC 2.1.1.98|Methanosarcina spelaei|TrEMBL
MLTFIGLGLFDEYDISLKGLEAIREADLVYAEFYTSCLMGTNLEKMEELYGKKVFLLSRE
DVEQHPDWLSKAKDRNLCFLTGGDTMVSTTHVDLRLRAEKLGIETHLIHGASIASAVSGL
TGLQNYRFGKSASIPHPYESRRGTRIISETPYDIIKQNLELGLHTLVFLDIDKEKGYMTV
NTALELLLEVEEKRREGIIRGAAAVGIARAGSEKPTVKADYAENLKDFNFGKPLHILVIP
GKLHFLEAEALMKLAGGPIGFMEEVE
>A0A7J9NUR8|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIESTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISDETKVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>A0A2I0PEJ5|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon HGW-Methanomicrobiales-3|TrEMBL
MLTFVGLGLFDKTDISVKGLRCIERADAVFLECYTSRLMGTSIEELEEFYHKPVRPLYRE
DVEQHPDEILTLAQEKEVVFLCAGDPMVSTTHADLRIRADERGIPTAIIHAASISSAICG
LSGLQNYRFGKSCSLPFPQKNWFPTTPFDVITANLAQRLHTLVYLDIQNERYMTIPEAVE
IIEQIARDKKTNIPLYVGIARAGSDTPVVRAGPADRMLTAEFGAPLHILIVPAGLHDMEQ
EYLERFAGL
>A0A139CFZ6|diphthine synthase|EC 2.1.1.98|Methanolobus sp. T82-4|TrEMBL
MLTFIGLGLFDEKDISVKGLEAIRKADMVFAEFYTSVLMGTTVERLEELYGKEVHVLLRE
DVEQNPDWIEHAKRKDVVFLTGGDTMVSTTHVDLRLRAQDAGIETKLIHGASIASAICGL
SGLQNYRFGKASTIPHPYTSSRGRTIISETPYDTIKANKERDMHTLIFLDIDREKGYMAV
NQAMELLLEVEEQRGEGVMENSIAVGIARAGSPEPVVKADYIHKLKDHDFGGPLHIVVIP
ADLHFIEAEALVKLAGAPAEIMSTVED
>L0KWS8|diphthine synthase|EC 2.1.1.98|Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)|TrEMBL
MLTFIGLGLFDEKDISLKGLEAIARANRVYAEFYTSRLMGTTLEKMEGLYNKKITVLTRE
EVEQYPNWLEHAINEDVVFLTGGDTMVSTTHVDLRLRAMEMGITTKLVHGSSISSAVCGL
TGLQNYRFGKAVTVPHPYTSSRGKTVISETPYDTVLQNLEHGLHTLVFLDIDKEKGYMTV
NQALDLLLQVEAKRSTNILQDRIAVGIARAGSDFPAVAADHIQRLKNFDFGAPLHIMIIP
ADTHFVEAESLVKLAHAPKSILEVHNQ
>A0A8F5ZES7|diphthine synthase|EC 2.1.1.98|Methanospirillum hungatei|TrEMBL
MLIFVGLGLYDLDDISIKGLRAIEQADTIFLESYTSILMGANPDLMRELYKKPITILKRQ
DVEQYPEPILTAAKSGNAVFLTGGDPMVSTTHADLRIRAKEQDIQTKIIHGSSIVSAVCG
LSGLQNYRFGKSCSIPYPAKNWFPKTPLDTILSNIQQNLHTTVYLDIQENRFMTVHEGID
LLEKLMEGSSDTIPLYVGIARAGSDNPIVAAGSSTQLKHIDFGPPLHILVIPGTLHEIEE
EYLKIFAGYEP
>G0H4F6|diphthine synthase|EC 2.1.1.98|Methanococcus maripaludis X1|TrEMBL
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISDETKVAVVARAGSINPGLYYGKIKDLLNHDFKSPLHCVIIPGKL
HFMEEDALKYLFENI
>T2GLB9|diphthine synthase|EC 2.1.1.98|Methanothermobacter sp. CaT2|TrEMBL
MLYIIGLGLYDENDISVKGLKALKACSRVYAEFYTAILQGASLSAIEELTGKDIDILRRE
EIEEERVPLLEAEKSDVALLVPGDPLIATTHTELILDARRRGIETRVIHASSIISAAPGL
AGLQAYKFGRIITVPFTSENYFPTSPYVNIKDNLERDSHSLVLLDIEAHKRRYMTANEGL
EYLLRASEKLGDDTINGKTLAVVIARAGSERPLVRAEAISSLLKEDFGDPLHCLVVPAGL
HFIEAEYLVEVAGAPRSIVEAMII
>M0G1N2|diphthine synthase|EC 2.1.1.98|Haloferax sp. ATCC BAA-645|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEASHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVGWEGRRGV
EVDGDQYMTADYAAELFAEHWDADALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A8J7RE31|diphthine synthase|EC 2.1.1.98|Halorubrum trapanicum|TrEMBL
MLTFIGLGLYDERSITVEGREALRGTDRVFAEFYTSRLVGADVADLEAYHDVDVEVRDRA
GVERDPEPILEAAESGDAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAADLLAEAWDDELAVVVARAGSPGAVVAADRLSALAAREFGDPLHLLVI
PGDLHHVEADALVGLADAPESLVEE
>A0A1V4V1T1|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaB.Bin087|TrEMBL
MLSFVGLGLYDERDVSVKGLQTIMDADLVYAEFYTSRLMGATPEKLARFYGKEIQLLSRE
EVEVSPEDWMGRAKEEKVAFLVGGDPMISTTHLDLRLRALRMGIKTRIVHSSSIVTAASG
LVGLQNYRFGRSTSIPYPYVAGGRRIVAMSPRDVVVENLARDLHTLLFLDIQPERYMTAG
EGAALLLEMETAAGADRLNSSLGVGVARAGSEDAVVVADWLPRLPERDLGDPLQILIVPA
RLHFMEAEALVALAGAPPEILEVAEP
>A0A843KN89|diphthine synthase|EC 2.1.1.98|Methanoculleus sp|TrEMBL
MLTFVGLGLYDPEDISVKGLECVKSADVVYLESYTSRLMGTDVAGMEAFFGKEVRVLARE
DVEQDPRDIIEHALHGHVAFLTGGDPMVSTTHADLRIRAAAAGVATAIVHASSISSAVCG
LSGLQNYRFGKSCSVPFPAKGWFPTAPVETIAANLACNLHTLVYLDIQKDRYMRIPEAIA
IVEEMAAKRGIEPPALYVGIARAGSACPVVAAGTGADLKETDFGPPLHILVVPGDLHPVE
REYLEIFAGL
>A0A6B2CVD1|diphthine synthase|EC 2.1.1.98|Pyrobaculum sp|TrEMBL
MLYIVGLGPGPGYATEAALRAIREADCVFYEDYTGPLDLETLRRAAVEEPVRLNRRDLEE
ESGRRIFECLREGRRAVLVTAGDPALATSHHALVALARARGFPVQIIPGVSIICAAFSAA
CLSIYKLGGVATVTYPRGGIYSRRPYELAEQNLRRDMHTLLLLDVREDGFFMPPRDAAEI
LLRLEEEEQRGVFTPDRHVAVVYRLGWGGSTLYTQLRDLLSLEAEGPAVIIVPARLSPVE
KECLEAAARRPAGEAP
>A0A7D5DZ34|diphthine synthase|EC 2.1.1.98|Halarchaeum sp. CBA1220|TrEMBL
MLTFVGLGLYDESSVTVEGRDAIAAADRAFAEFYTSHLVGADVADLEAYHDTDIEVRDRA
GVEQHPEPILDAAEAGDAVFLTAGDTMISTTHVDLRLRAHERGIETRVIHAPTAESAASS
LTGLQNYRFGKATTLPFEWAHGADVVPDSVIATLEDNRERGLHTLCYLDIKVGRGPEGED
PDFEEYMSADYAAGLLAEAWDPDALGVVVARAGSPDPVVRADRLDRLADESFGDPLHMLV
VPGDLHHVEADALAGLAGAPDDLLPE
>M0EZY9|diphthine synthase|EC 2.1.1.98|Halorubrum distributum JCM 10118|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKSTTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>M0MMJ6|diphthine synthase|EC 2.1.1.98|Halococcus morrhuae DSM 1307|TrEMBL
MLTFVGLGLYDERSITVQGQEALRDADRVFAEFYTSRLVGTTIEELESHHGIAIEVRDRA
GVEQEPAPILDAAEAGSTVFLVAGDPMVSTTHTDLRLRAHERGIETRIVHGTTAQTAAGS
LTGLQNYRFGKATTIPFAYRDRPIPESVVETIEGNRDRGLHTLCYLDIKAAEGRYMSADV
AAARLAPELDGLGVVVARAGSPEPLVVADRLSALAGGAFGDPLHLLVLPGELHHLEREAL
EALADAPPELL
>A0A7J3FE50|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
VSAAAGLTGLQSYKFGRSTTVPLPDLKSIHPYEVLGENTERGLHTLLFLDVRCESRTYLS
APQAIQILLQLEEQERRGYFTGQRLVVVIARAGADNCVVRGDRAANLLKQDFGPVPHVLV
VPGRLHFLEARALEVFAGVPEDVVRELEG
>A0A1D2QXB5|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeales archaeon WOR_SM1_79|TrEMBL
MGELIFIGLGLYDERDISLNGLETARDCDILFAEFYTSKLTGTTISQIESLIGRKITILN
REEMEKGDIIIEAAKENKVGVLVAGDPMTATTHMALRMSAKQEGLNIRIVHGTSIITSAP
ALSGLHIYKFGSIASLPFPKKGYFPTSPYDIIKLNLDCGLHTLILLDIDEEVGKLMRANE
ALKILLDMESEKKEGIISGNTLVCVLGSVGSKRPVVRADYLNELLKEDFGEGLNCLIIPG
KLHFTEVEALVELAGAPKAILARV
>A0A842MR85|diphthine synthase|EC 2.1.1.98|Hadesarchaea archaeon|TrEMBL
MLTFIGLGLGSEGISLRGLREAQEAEVVYAELYTSLIPGLDIAQLERRIGKPVKIVSRKI
VEENPQEILEAAKQGKVSFLVPGDPMVATTHVDLRLRAARAGVETKIIHAASIASAAAGL
LGLQSYKFGPSATVPFLDNLSTRPYEITAENLRHGWHTMLFLDLREERAMTANEAVEVMI
GMEEKLRGEIFTPDRLLAVVARAGASDCVVRADRAESLRSEDFGPPPHLLVVPGRLHFVE
AEALEVFARAPKEVLQWHMNRR
>A0A842SGA0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTLKLVSIGLRDHLDLSLRAIEEIKTSEKVYFESYTMKLDTNYEQLEETTGKKVSILERG
AMEEEASNLLREAAVQDISILVGGDALSATTHVSLLIDAKKQGIDTKVIHGASILTAIAE
TGLSIYKFGRTVTVPLPQKGPVDTVIRTLRENREHGLHTLLLLDLNIPGAEYLTIPQALI
RLIDTDEFPPETLVVGLARIGSENQIIRADKAAQLISQSWGETPHAIVVPGRLHFLEEEA
LKVLADCPPELLEGRLVMGEVERLIDKYSRSCRKVLDTMVLEDFPMEINEKKVQELIDHT
ERYLSDTQYYWGENNPVALTSVAYAEGILDALKLLGLADFQW
>A0A7J2IV76|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MAGTLTFIGLGLYDEGGMTLKGLSAAKKADVVFLELYTSLMPGVSISRLEALLGKPVELV
SRHVLEEQDAEPLIGEALAGRDVALLVPGDPMVATTHVAIRLRAEGLGIRTRLIHAPSII
SAVVGLTGLQAYKFGRTATITYREGGILSEAPYRAIAENRARGLHTLCLLDARAEEGRFM
TIREGLELLLELEDELGEGVIGPSTLAIGVARAGSPEPVVRANAVGELLEQDFGPPPHAI
VIPGDLHFMEAEALRTLAGAPDWVASQRPPSPASRERKAEGAEELSEKYIGNLDFAFSTL
STREGSRAIGEREVEHVIDLARRYKEDAERFLEAGKHITSIAAASYAEGLLDALRLLGLV
EFSWPPKGGRG
>A0A7J2ZC09|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGELVFVGLGLHDEKGISLSGLEEAKAAEEIFLELYTNFMPNFSIEKFAEILGKKIHVVS
RRQLEEENGKTVLETAKRGKAVLLVPGDPLIATTHIALRIAAEKQGIKTRVIHGASIVSA
APGLSGLHNYKFGKSVTIPFPENFSETPYMVIAQNKGLGLHTLCLLDINVEENRFLGVRE
ALEILLRIEEKRKMGVVTCETLAVGIARAGSPNPTVKAGFVNELLNYDFGGPPYSLIFPG
KLHFMEAEALIVLAGAPSSVVELVE
>A0A2J6N1A0|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGISLRGLEEVKMADDVFIELYTSMMPNFSIRHFEEVSGKKVQAVSRRELEDDNGEKILR
AAKNRKVALLVPGDPLIATTHVALRIQAEKMGIKTRVVHGASIISAVVGLSGLHNYKFGK
SVTIPFPNGAFLKTPYEVVTQNKKLGLHTLCLLDVRAEEKRYLDINEALELLLESERKEK
LKTITDETLVVGIARAGSDNPTVKADFLSEIMKYDFGPPPHSLVFPGKLHFMEAEALVVL
AGAPKKVVEMVE
>A0A7J3XUX8|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MTLYFIGLGLCSPQDLSARGLEAAKRCSKVYVELYTSPTPRLRLEDLQALLGKEVKLVGR
GDVEGPWAEELIGEAALMDVALLTPGDPFIATTHNALRLEALRRGVRVCTIHAASVASAI
PGATGLSFYRFGRAVTLVRPEAGYAPEAAYNVVKENLSRGLHTLLLLDQGVERGEAMSAP
QALQTLLEVE
>A0A7K3ZT52|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MELVFVGLGLNDDKGITVKGLEETRTADAIFMETYTSRMPDFSMPRFEQATGRKVQLIKR
QDLEEDNGKVILQAAKAGKAVFLVPGDPFIATTHVTLRIDAEKAGIKTRVVHGISIMSAI
VSLSGLHNYKFGKTVTVPFADNFSETPYNVIAQNKKLGLHTLCLLDLRAAENRYLTINEG
LKLLLEVEAKKNLGIITAATPALGLARAGGDNPVLKADFVEKLVNYDFGQPPFSLIIPGD
MHFMEVDALIAFAGAPAEFKRLSR
>A0A257ASC4|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon ex4484_121|TrEMBL
MPIHLIGLGLGTIEYLTLGALETAERMDELLLDTYTSWIHPDLMKYLREKFGERLVKADR
SMLEERVDELIRKAEEKEIGILVPGDPLIATTHISIILEARRRKIPVYLIYGVSIISASA
SASGLQAYKFGRITTIPRDGVGVETCYRVVAENLEKGLHSLILLDTADGGLKIPDALKML
MRVEDKLGYGIFDRDSMVICLARIGSSEELRWAGRIIEALKLHYPPPPHLIIVPGELHFA
EVEALKEILGADEELVESYKPPRYERERARSYIMKVERVLDEIRIRVDSERVMEIIEIVK
SYLEDSKKFLENGEVFNAVAAISYAEGLLDSLRNIGYVDFEWPRT
>A0A832KH00|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
GLSLKGLEEVRRADLLFAELYTSFMPGLSVSRLEVLAGKRVRILSRRDLEEDAEPILLEP
AKAMRVCLLVPGDPMTATTHVDLRLRAEAMGVATRVVHAASIETAAPAAAGLQSYKFGRS
VTVPFIEGCSLPGSIYDYCRDNKALGLHTLILLDLRVEEGRFMSIPEALMILSRLEESRG
EGVFPGDRLMVGMARLGGPDAVVKADRLEELMDFEFGGPPYTLIAPGRLHFVEAEALKVL
AGAPEEVFRDRGRG
>A0A7C2ZVB4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLAFIGIGLTAKGLTVEGLQEAKRADHLFIDSYTSLIPKDELFVLQSLIGREVKPLRRS
DLEGPGAQRILELAERGSVALLTVGDPFIATTHIALRIEATKRGIKVKYVPSASILSVIP
GLTGLSSYKFGRSATVVFPERDPNNAAYDAIRDNSSRGLHTLLYLDLDVEGGKAMTINEA
LKILLEVEARRGEGVIRGDRLVVGIARACWDSEVVKASRLSKLIDYDFGPPPHVLVFPGS
LHFVELEALKILAGMEECP
>A0A497NB43|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLGLRGLGGLTLEGLEKARKADKIYVELYTSPLAEFSLEKLAELTGKKPVLLAREDLED
KGGEAVLRDAEQGWVAFMAPGDPLIATTHVDLRIRALRRGITVEVVHAPSIYSAAASISG
LQAYKFGRTVTIPFPQPGYQPETPYDVVKENLSRGLHTLLLLDYRAEEGRWMTVREGLEY
LASIEKRRGEGVAHEGRLVVGLAGVGGCDVEVYGGSLKRMLSQKFTLKPQTIIVPGSLHF
MEAEALKAVAGVKPEELKVEG
>A0A7J3J5T9|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
SYTSLMPGFSLENFERLVGKRVVIVSRRHLEDENGRVVLDAAGKGKAVLLVPGDPLVATT
HVALRLEAEKRGIKTRVVHGASIVSAVMGLCGLHNYKFGRSVTIPFPENFSETPYMVLAQ
NRSLGLHTLCLLDIDVERNRFLTIREALETLLKIEAERRLGVVGGETLTVGVARAGSPSP
TVKAGTVRELLYYDFGGPPYSLIFPGKLHFMEAEALIILAKAPAAVRRLVE
>A0A7K4I6U4|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
RVSAEKIGIKTRIVHGASILSAIMGLSGLHNYKFGKSVTIPFPEQTFSETPYEVIAQNQM
LGLHTLCLLDIIAEEKRYLSISESLKLLLKIEEKKKRKIITEETLAVGIARAGSNSPTVK
ADAVKKLMNYDFGGPPYTLIFPGKLHFMEAEALIVLAGAPEKLRDDAL
>A0A1Q7PZ53|diphthine synthase|EC 2.1.1.98|archaeon 13_1_40CM_2_52_4|TrEMBL
MSLTFIGLGLNDERGITLEGLEEARRADAAYAEFYTNLMPNLDLRRLEQEIGKKVEVLSR
TQLEDEGGQELLRAASKERVVFLVPGDPMIATTHVSLRLSLARMGIASRVVHAPSVVSAV
CGATGLQSYKFGKSITVPRDQPFPRSVLETISDNNDRGLHTLILLDVQAGETSQMTIRDA
LAKMTVADHRLETRLAVGVARLGSRDEKVKASRMKTLTNEDFGKGPHSIIVVGRLHFMEA
EALKLLCGADAKDLSELT
>A0A6B0YNL0|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0665_bin_23|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A2D6K564|diphthine synthase|EC 2.1.1.98|Nanoarchaeota archaeon|TrEMBL
MLSLIGIGLSDEKDITVKGLEIVRSADVVYLEGYTSLLQCSIQDLEEFYQKKVIAANRET
VESDTLVDEAVDKNVVLLIIGDPFSATTHVEMASACKEKNIEFQVVHNASVLTAIGETGL
QLYKFGRTASIPFIEDHPNLETPYNILRQNKLLDMHTLFLLDLKPEQNRFMIVSEALQIL
EQIESRKQEKVISDDLLVVGCARLGSDSIIKAGKLSDIKKFDFGKPLHSLIIPGDLHFVE
EEYLHLL
>B3V612|diphthine synthase|EC 2.1.1.98|uncultured marine group III euryarchaeote AD1000-40-D7|TrEMBL
MLTIIGLGLGGPNSITMDGVIALSLSDHIFYETYTSPIHPETLEWVKLKSQKEPIHLSRG
QVEEPAELIDLAKEKNIALLIVGDALSATTHVSLLLECKKNKIEYQVIHNASVLTAVAGV
LGLQHYNFGPVATLVLPEGNYKPTSPIDKIKANMKNGNHTLVLLDIKADQPETEAIYMTA
SQAAEQIMEAGLSGEIKVAAAARVGREDQKLWYGKLKDLAKTDLGKEPHSLVVPSRLHFT
EKDFLDNL
>A0A328PEG9|diphthine synthase|EC 2.1.1.98|Methanothermobacter tenebrarum|TrEMBL
MLYIIGLGLYDEDDISIKGMKTLKRCDRIFAEFYTAKLKDQKLSTIREKTGKDVKILARE
EIEEDMTPLKYAQGEDVALLVPGDPLVATTHSNLILEARKKNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEKNYFPHSPYLTIKDNLEYNAHTLILLDIKAEENRYMSANEGL
EYLLRVEKERKENIIDLNTLAVVLARVGSSDPLIRADLIKRLIVEDFGRPLHCLIIPSTL
HFLEAEYLIEIGGAPPDILK
>A0A7J9RK79|diphthine synthase|EC 2.1.1.98|Methanophagales archaeon|TrEMBL
MLTFVGLGLYNEEDITLKGQVAIRDADIVFAEFYTSPLGGRTVERMKEIYGKRIIRLERS
EIEEQAEEVILNQAKNQDVVLLSGGDAMIATTHIDLRLRAIDAGIETRIVHAPSISSAVA
GISGLQNYKFGKSATVSPPYRDAISEVPYETVRANKERGLHTLLYLDLSMSINDALDLLE
AVEDRKAKENFGGGTFKLKRSVFIGIARAGSDDQVVKADYMGGLKSYEFGELPHVLIVPG
ELHFLEREALIKIADAPESI
>A0A2Z2M5D8|diphthine synthase|EC 2.1.1.98|Thermococcus gorgonarius|TrEMBL
MVLYFIGLGLYDEKDITLKGLEIARKCDEVFAEFYTSLLAGTTIEKIEELIGKPIRRLSR
EDVELNFERIVLPAAKEKDVAFLTAGDPMVATTHSDLRIRAKKAGVESYVIHAPSIYSAV
AITGLHIYKFGKSATVAYPEKNWFPTSHYDVIRENKERNLHTLLFLDIKADQGRYMTANE
AMEILLKVEEMKGQGVFTPDTLVVVLARAGSLNPTLRAGYVKDLINEDFGRQPHVLIVPG
RLHIVEAEYLVEFAGAPEEILRDV
>A0A0E3NLZ9|diphthine synthase|EC 2.1.1.98|Methanosarcina sp. WWM596|TrEMBL
MLTFIGLGLFDEYDISLKGLEAVQEADIVYAEFYTSCLMGTNPKKMEHLYEKKVHLLSRE
DVEQQPDWLNEAKDKNVVFLTGGDTMVSTTHVDLRLRAEKLGIETRLVHGASITSAVSGL
TGLQNYRFGKSASIPYPYESRRGARIISETPYDTIKLNSELGLHTLVFLDIDKDKGYMTV
NLALALLLEVENKRREKVMDRAVAVGIARAGSEKPVVKADYAENLKDFDFGKPLHILVIP
GKLHFLEAEALVKLAAGPEKLMEGIE
>H1YWB8|diphthine synthase|EC 2.1.1.98|Methanoplanus limicola DSM 2279|TrEMBL
MLIFIGLGLFDERDISIKGLETVKSADRVFLEAYTSRLMGADTARLEEYYGKEVKVLYRE
DVENNPEDILIAAENGTAAFLTAGDPMVSTTHSDLRIRAEERGIETGIIHGASIQSAICG
LSGLQNYRFGKSCSVPYPEKGWFPLTPAETIRSNMAQGLHTLVYLDIKPDRYMTVNEGVE
LISEMCKRREEEPPELFVGIARAGSDRPVVRAGRGPDLIAYDFGGPLQILIVPAELHMME
EEYLRVFAGL
>M0N6D7|diphthine synthase|EC 2.1.1.98|Halococcus salifodinae DSM 8989|TrEMBL
MLTFVGLGLYDERSITVEGQDALADADRVFAEFYTSKLAGASIGDLEAYHDHEIEIRDRA
GVEQEPAPILDAAEGGEVAFVVAGDPMISTTHTDLRLRAHERNIDTRVIHGTTAQAAASS
LTGLQNYRFGKATTIPFAYGDGDIPQSVLDTIDANRERGLHTLCYLDIKAAEDRYMTAST
AAERLAPGLDDPLGVVVARAGSPDPVVAGDRLSALAQQDFGDPLHLLVIPGDLHHVERDA
LVGLCDVPEDLV
>A0A6G2KXE6|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0672_bin_9|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A643K040|diphthine synthase|EC 2.1.1.98|Haloferax sp. CBA1149|TrEMBL
MLTFIGLGLFDERSISVEGREALADADRAFAEFYTSHLVGATVEDLETYHDIDIEVRDRA
GVEQDPEEILAAAEEEHVAFLTAGDTMISTTHVDLRLRAEARGIETHLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRERGLHTLVYLDIKVDWEGRRGV
EVEGDQYMTADYAAELFAEHWDGDALGVAVCRAGSREPVVAADRLSELAKQDFGDPLHML
IIPGEVHHVEADALMGLGGAPEDLFDYDER
>A0A7J3DPJ4|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLILAGLGLFDEKDLTIREIEEAKKADKVFVELYTSKWHGSLEKLEETIGKKVEILKRED
LEEKNEKIIESAKFGRVLIFVVGDPLVATTHISLIQEARKMGIKTKVIHNASIISAIAET
GLHMYKFGPSVTIPFPEKTKGKLPESVYDVIKMNRARGLHTLCLLDVIDEKVMEPKEAIE
ILLNLENARKENVIKEDLGIVIFSKAGSEEAKIVFNSIKKLRGKKFDVPAVIIIPGILHF
TEREFLSTFV
>A0A842WGF9|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeota archaeon|TrEMBL
DITEGGMNALRESDAAFCEVHTMPVPREYVEKLEAESGKKIEIIGREEVEGSILIEKAKD
ENVCLLCGGDPLAATTHISLLVDAQKAGVGARVVHNSSVLSAAAGKSGLQPYRFGKTVTV
SFWRENYQPTSPLRLIEKNLDAGMHTLVLMDLDKELGLMDAKMGLGLLGKMEEKEGRGVL
PEKVVVLSRVGYPDEKVSWGEVGEIMERWLGKAPFCIVVPASLHKVEKEYLESL
>A0A496SN42|diphthine synthase|EC 2.1.1.98|Candidatus Latescibacteria bacterium|TrEMBL
MLAFVGIGLHDERDITLKGLEMARKCDRVYMELYTSVMDMDMKKLEEMIGKKVEILSREE
VEEGGKIIEEAKEMDVCLLVPGDPMMATTHVELRLRAMEEGIETSIIHGISIITASAGLL
GLQIYKFGRVVSIARPYENYFPLSPYDRIKENVKAGLHTLLLLDIGEKPMTANEGMEILL
EMERRKGDGIISSDTLIAVVARASSNDAMIRAGYIKDLMKEDFGSPPHCIVIPGDMHFME
AQSLVKIAGAPENILKKFRRDN
>A0A662JMS8|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MRWLQLAELIFVGVGLTGLGLTIEGLRAAREADEVFVDSYTSLLPEGSLEQLEEVIGRSV
KPLSRGDLEGEGALKLVELARDKRVALLVAGDPFIATTHVALRVEAFKRGVKTSYIPSAS
IQSVIPGLTGLSSYKFGRSATVVYPDKGLNHAAYEAVRDNQLRGLHTLLYLDLEVERSRA
MTVSQALQLLLEVEEERREGVIDGEKLVVGVARACWPSCLVKALRVRKALSFDFGPPPHV
LVFPGSLHFMEVEALKTLASLEV
>A0A497FJI6|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MVLLCVGRVGVLLYFVGLGLSAKDISLRALSVLNSCDIVYLDSYTSILAEGGLDEIRRLI
KPGKLAVVGRDFLEEHVEEILRKAEERRVAIAVIGDPFIATTHISIRVEAAKRGIKTSVI
HASSILSAAISESGLQAYKFGKSATIVFPEKDYRPTYPYRVLLENLMRGLHTLFFLDFKA
ERGASMTIRDGLSLLLEMEREEGEGVLDEGCLAVGLSRLGSEKSITYAGSFKDLQIYDFG
PPPHTLIIPGILHPMEEEALIYICRAPKKVVKEWTRRATAIKLRGTLKG
>A0A662GM87|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MTGILGFVGLGLGKGDITLKGLDFLRKCSIIYFDTYTSLSSEINQAYLEELTGKTVKPVN
REFLETEKRKEIYQRCLKGENVAIACIGNPFFATTHVALRIEAEKLGIKTEVFNSFSILD
GILSATGLEPYKLGKIVTIVYPEPEYGYFPTTPYKVLRENLARGLHTIFLLDLKLEKKLA
MTIPEAIELLTSMEKQFNEGVITEATIGIGLARVGTSTQVVKAGKLRKLEKMDFGEPPHT
LIIPGTLDPIEREALKILGNIEDEAITEWLQRLKEKPKNT
>A0A5E4KHI5|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVRKADIVYAEFYTSHLVGTAIDKMEGLYGKKVTVLTRE
DVEQNPLWLSKAKEENVVFLTGGDAMVATTHIDLRLRALDMGIDTAIIHAPSISSAVCGL
CGLQNYRFGKSTTIPFPYTRKDKTIVSEAPYDTIKMNKRNDLHTLVFLDIDREKGFMQIG
KAVSILIEMEERRGEGILVNTLAVGIARAGSQSPAVHADYIEKLKKCDFGAPLHVLVIPA
SLHFIEAEALVKLCGAPPEIMK
>A0A5E4JXU0|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MTLNLIGTGLNEKSITLEALEAIKKSKKVYLENYTVDFPYPKTKLEKVIKRKITELTREQ
VESLEFLKEATSVSLLKNKRANDKNKKSTNAKREPKQDISLLVYGDSLSATTHSEIILTC
KNNEIPFKIFHNASVMTAIAETGLQLYKFGKTASMPTWKNNWKPDSFMEIVKQNQSIQAH
TLLLVDIALDLEKAKQQLKEAMKNHNLEIEQIVLCSNLGNEATIIYDKIENLPKEITKPY
CFIIPSRLHFHEQEFLDKCHPQ
>A0A5E4ICF0|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MFRNLSTPGIRYLNVKTMNGCEKMLKGQLVFVGLGLYDETDISLKGLQEIKQCDEVFAEF
YTTKLGEFDKKAFEKLIGKKIEVLSREETENGERIINAAAQNHVVFITGGDPMIATTHVD
LRLRAIKQGIPTKIIHSSSISTAVPGILGLQNYKFGRTTTLAFGEKEYFPTSPYSVIYYN
RKMGLHTLVLLDIQVEKNRYMMANEGLELLLRMEDKLRKNLLSDDNIACVVARAGAPDSV
VAANTINALRKKDFGPPLHTLVIPGKLHFMEVEALELCAGLPPELGEKKYKNYNNPR
>A0A0N9MVG1|diphthine synthase|EC 2.1.1.98|Halanaeroarchaeum sulfurireducens|TrEMBL
MLTFIGLGLYDEHSITVAGQAALRDADAVFAEFYTSRLVGTSVDDLESYHDVTIEVRDRA
GVEREPDPILAAAREGDAAFLTAGDTMISTTHVDLRLRAHERGIETRVIHAPTAETAASS
LTGLQNYRFGKATTLPFPWAHGADGVPGSVIDTLEDNLDRGLHTLVYLDIKAAKEEYMNA
TTAADILRQHWNEDVLGVVVARAGSPETVVRADSLLGLANEDFGDPLHLLIVPGDLHHVE
AEALRTLAGAPDALL
>A0A4Y5SQU2|diphthine synthase|EC 2.1.1.98|Thermococcus indicus|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCDLVFAEFYTSLLAGTTLDRVEELIGKPIRRLSR
EEVELYFEHIVLSEAKERDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AITGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMARNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKKENVFTPDTLVVVLARAGSLNPTLRAGYVRDMLKEDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A0A2G9LM22|diphthine synthase|EC 2.1.1.98|Candidatus Altiarchaeum sp. CG12_big_fil_rev_8_21_14_0_65_33_22|TrEMBL
MLYLIGIGLYDEKDISLRAIEILKSADEIYVEDYTNFYHGNLKNLSEITSRNITILKRND
IESGEILYKDALLKNIALLVPGDPMIATTHSSIILDAEKRRIKVKVIHSSSIYSAIAETG
LMIYKFGRTTTIAFPYIDTIPSSPYKFFMENSERNLHTLMLLDIDVEDNKFLSINQGLEI
LLKLEKDAKGNIMQKATFVCCARLGSDDAIIKAINGADIEKILNFDFGNPPHCIIAAANL
HFIEEEMITRFY
>A0A1J5CAI1|diphthine synthase|EC 2.1.1.98|archaeon CG2_30_31_98|TrEMBL
MFVLVGLGLKLEHLTLEALEIIKACDKVFLEKYTLDISYDFDALTKLTGKNIKLIERKDV
ESYSFLPLSEEKDKKTNKNVALLVFGDPLIATTHTELLLEAKQRGLETRIIHNISILNVI
SRTGLQPYKFGKIASIPFWQENIEYRPCGFYNLLEQNQKIGAHTLFLLDLNPIDNKYLSP
GLAIEMLIKCEMLKKKQIINEDTLFIVCSRLCSNTEKIVVGKYNKIKSIGFGLPPHCIII
PSPPHFKEQEFLSQFNSS
>A0A830E1Z1|diphthine synthase|EC 2.1.1.98|Haloferax sulfurifontis|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFVEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVAFLTAGDTMISTTHVDLRLRAEDRGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGDPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A3R7AT78|diphthine synthase|EC 2.1.1.98|Candidatus Woesearchaeota archaeon|TrEMBL
MLYLIGLGLNDWKDITLRGYEAMMKCEYVYLDFYTAVLQNNLREIEDAFKKSIIPADRDL
VEKRADEILKNAKLKNVAFLVVGDVFSATTHIDLFLRAKEKNIPVEVVHNASIITAIGDT
GLQVYNFGKTASIPFPHENFYPETAYDVLKMNKSMGLHTLMLLDLNPKQGSFMDMREALE
ILLNIEHKRKENVVSPETMALGCARLGGNKKIKYAKIVDLLIEDFGEPMHCLIFPGNLHF
LEEEMLKQWE
>A0A8A2U664|diphthine synthase|EC 2.1.1.98|Haloterrigena longa|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRVYAEFYTSELIGTTIDDLESYHDAEIEVRDRA
GVEQHPEEMLEAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSA
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDDNRADGLHTVVYLDIKVEREEYMTA
DTGATLLAEEYPDLVGVVVARAGSPEPLVEAGTMSELAGREFGDPLHLLVVPGECHLLEA
DALVELAGADRDALEIA
>A0A497Q6H6|diphthine synthase|EC 2.1.1.98|Thorarchaeota archaeon (strain OWC)|TrEMBL
ILESAEKEKVCFLVVGDPMIATTHIDLRLRAIEKNIPTKIIHGSSIVTAVPGLLGLQNYK
FGRTTTLAYPEKDYFPISPYHIIKENKEMGLHTLVLLDIKADRNKYMTANEGIKHLLEME
KKQDMKVFAGNSIICVVARAGSAKPIIKAGEADALLNEDFGPPLHTLVVPGNLHFMELEA
LVKIAGLPEEIGKKMQKL
>A0A7J4SA24|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniaceae archaeon|TrEMBL
MAEDSDKLKQTGLVLIGMGPNMLTSMTEEAIVAAESADFRYYEAYTAIWPIEELDRLERR
VGSIKKVMRPEVEQPEEIFNLAKANNVAVLVVGDPLQATTHVDLQLQAEEHGIDCRIVHG
ISITNIVTGAIGLSNYKFGRQTTLTYPYSNWIATSPLEILAMNRIMGHHTLALLDLDPTG
AGTGKQQPMRPRDAVAS
>M0CYJ9|diphthine synthase|EC 2.1.1.98|Halorubrum terrestre JCM 10247|TrEMBL
MLTFIGLGLYDERSVTVEGREALREADRVFAEFYTSRLVGADVADLEASHDVDIEVRDRA
GVERDPEPILEAAASGDAAFLTAGDTMISTTHTDLRLRAEERGIETRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVVETIEANRERGLHTVVYLDIKVGTGPSGPD
PDHEEYMTADVAAGLLADNWGDELAVVVARAGSPDAVVAADRLSALAEREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLAEE
>A0A662JWN7|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MPNGEIVFIGLGLYDEKDVSVKGLEVARSCVKLFAEFYTSELAGSSLQRLQEFFGKPIKV
LGREEVEKGDVILDAAEERRVGFLTAGDVFAATTHVDIRLRAEKRGIKTRVVHGSSVFTA
VPALLGLQHYKFGRTTTLVYPEGSYFPVSPYSVVEENLERGLHTLVLLDINREAGRYMTI
SEGVDLLLMMAEKSNSTLLGEDTLMCGVARAGSDNPMVRAGSAKTLKKLDFGPPLHTIVV
PGNLHFVEEEALRAFAGMR
>A0A7J2S6H3|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLSFIGLGLWDEKDITLKGLEEARKCDKIYAEFYTSRMGVDIERIEKLIGNKIEVLSREE
VENGEKILRDAKSKNVCFLTCGDTMSATTHVELRLRAIDMGIKIKVIHGVSIVSACASLL
GLQIYKFGRVVSIAKPYKNYFPLSPYDAIKENMSMGLHSLLLLDTTDGLMTANEAMHILL
EMEKRKKENIITPDTLIAVVARVSSLSAFSIADYIKNLIDGDFGETPHSIVIPGKLHFVE
AEALVKISNAPEEIIEKRG
>A0A7K3ZJM1|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MTSELIFVGLGLSGTDGMTVKALGALKECDRIYAEFYTSSLLDAKVSDLEAAVGRPVKIV
YRAQVEEGDDIIGDAKKMRVGFVTAGDTMAATTHVDLRIQAEEEGIPVRVFHGISIFSAC
PSSLGLQPYKFGRTVTLPFIDDGYHPRSPYDHICENRERGLHTMILLDIRADELRYMTAH
QAVEWLIEAEGKWGRGLITDGTLLCVASKVGSSEERLFAGYPQDLLKMDLGEPLHTLILP
GDLHFMEAYALAYFAGAPREILEDQ
>A0A2R6I6I5|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon QS_4_70_19|TrEMBL
MLTFVGLGLWDERSITVEGRDAIRGADRVFAEFYTSKLAGATVDDLEASHDIDVTVRDRE
GVERTPDPILDAAASGDAVFCTAGDTMVATTHVDLRLRAHERGIETRVVHGTTAAAAAAS
LTSLQNYRFGKATTLPFPYAHGGDDVPGSVLDTVDANRERGLHTLCFLDIKVAHELAATD
EYMTASTAAGLLTDAGREDDLGVAVARAGSPSPVVAADRLSALAGRDFGDPLHLLVLPGD
LHHVERDALVALADAPAALADERLA
>A0A172WFJ4|diphthine synthase|EC 2.1.1.98|Thermococcus piezophilus|TrEMBL
MAIYFIGLGLYDEKDITLKGLEMARKCDLVFAEFYTSLLAGTTLDKIEGLIGKPLRRLSR
EEVELQFERIVLSEAKGKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AMTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENKERGLHTMLFLDIKAEQNRYMTANE
AMEILLQVEEMKKQGIFTPETLVVVLARAGSLTPTLKAGYVKDMLKEDFGRQPHVMVVPG
KLHIVEAEYLVAFAGAPKDILDEV
>A0A7J4NI33|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MDGSGLWLIGLGPGDLNHMSISALSAAKAANYRFLEGYTALLPPEELGNLEEVVGPWELR
MRSSVEQPEELLDLAQNHRVALLVVGDPLQATTHVDLQLRCAQRQIPCHIEHGISITTIV
TGAVGLQSYRFGRQCTFAYPYGDYLPISPLEIILENKERGLHTLALLDLDPTGMGEGDQQ
PMTPKVAIEVLRNMAQKLGVDIEGWTLVLCSDMGTDDAKVNVGTAQQISELTSGRIHCLL
VPAELHDVEDAALARW
>A0A7J4SR25|diphthine synthase|EC 2.1.1.98|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MKAGLRLIGIGPGDLGLMTVDAIAAAKESDHRFLEGYTATLPPEQEDLLESRIGPWTRLM
RPDIEMPDELLRLARSSVVALLVVGDPMQATTHVDLLLRAKDAGLDTEMIPGVSATTLAI
TLSGLQSYRFGRQVTLPFPYGDYLPVSPLKYILDNKSRNLHTLVLLDLDPTGLGVESPVH
MSPAEAGGVFLKMAKKYGMEDDSKIGTFEDMPDWPVIVLSDLGTKESRVCSIYLRGISNV
KGGRIHCLILPSSMDDLEQSSFDGMYVGD
>M0NX83|diphthine synthase|EC 2.1.1.98|Halorubrum lipolyticum DSM 21995|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRVFAEFYTSRLVGADVDDLEAYHDAEIEVRSRE
GVERDPEAILAAAADGHAAFLTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVIDTIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADGWEDALAVVVARAGAPDAVVAADRLSALAQREFGDPLHLLVI
PGDLHHVEADALAGLAGAPADLIEE
>A0A2H9M7D0|diphthine synthase|EC 2.1.1.98|Candidatus Huberarchaeum crystalense|TrEMBL
MFVLVGLGLKLEHLTLEALEIIKACDKVFLEKYTLDISYDFDALTKLTGKNIKLIERKDV
ESYSFLPLSEEKDKKTNKNVALLVFGDPLIATTHTELLLEAKQRGLETRIIHNISILNVI
SRTGLQPYKFGKIASIPFWQENIEYRPCGFYNLLEQNQKIGAHTLFLLDLNPIDNKYLSP
GLAIEMLIKCEMLKKKQIINEDTLFIVCSRLCSNTEKIVVGKYNKIKSIGFGLPPHCIII
PSPPHFKEQEFLSQFNSS
>A0A0A7V1N2|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopelagicus brevis|TrEMBL
MLWFIGLGISGISELSNSTLEVIKNAEIVYLESFTSPISDTEKKQLEDISGGEFKTAKRW
LVEDGNEILENAKNRKTVLISYGDPYIATTHLELKTRAIRDDIETRTIHSSSIVSSLIGE
VGLHYYKVGKVLTIMNDPKSMITPYNTIFENLLGKTHSVILLEYNEDKSFFLDPKDALSL
LLNTEKTQNRKVISEETFAIVASRIGKDSQKIISGNISNLIKSDFGEAPHSIIIPGRLHF
TESDAVKTVTECLDEPTDNSADVKSISEQMIEKYVPMVREALAEIKPHYENLKEYEDVLI
NAKLYIDDAENFLKEGKKEYAVLSIGYADGLVDALRIAKGFDPKM
>A0A7C2D2E7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKELVFVGLGLHDEKGVSLQALEEIKTADYVFAELYTNFLPHFSIKRFEAMIKKQIHVVS
RRDLEEENGALILNTAETGKTVFLVPGDPFIATTHVTLRIEAEKRGIKTRIVPGASVISA
VIGLSGLHNYKFGKTVTIPFPENFSETPYNVIAQNRSLGLHTLCLLDIKVDEKRFLSINE
ALKMLLAIEQKRKDGIVTPATLAVGVARAGGRRPTLKADYIKTLLEHDFGDPPQSLIFPA
ELHFMEAEALVVLAGAPKTLRRIA
>A0A836PSX9|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosopelagicus sp|TrEMBL
MLWFVGLGVSGPDSIPKEVGKIIQKADLVYLESFTSPIYKEHEEDIKNLVNGNFKIAKRW
LVEDGQEILKAAKNSTVILLSYGDPYIATTHIELRTRAKLENIETKTAHSASVITSMIGE
VGLQFYKVGRIVTIMSEKKSITTPYKIIFKNLIEGIHSVILLEYNQDENFFLDPKDAILS
LLDAEKEQKRNVVNENTFAVVVSRIGLKTQKITSGKFTNLLKTNFGEPPHSIIITGKLHF
TESDAISVLTECLDKPLDNSSRIKSVSIQMIEKYVPLVREALEEIKPFYNDSKEFCEILQ
NAELYINDAEDFLKQGKDENAVLSIGYADGLVDALRMAKGIDPKM
>A0A7C4JKD6|diphthine synthase|EC 2.1.1.98|Ignisphaera aggregans|TrEMBL
MNTLIKLIGLGLSIDLLPIGVLLRLLSCERIYMDTYTSNWFPSIYDLANILKQFGIEVIM
AKRKDLEGGSINKIVEEAKLSNICIAVIGDPLIATTHSAITVEALSKNVEVEVLPASSIL
NTAISLSCLQVYRFGKTVTIVKPKNGVLYEYPLQVIKMNRDRDLHTLTLLEIDLEQEYYM
TPKEAIELLLIIQKNTNNNVLNEKDKIIVLKAIGFENGSIEVMSVEEILGKEFEKTLYTL
IIPAKTLHPIEEECLRNIGKILIKPQLNINMLESIIKIIADNMKQKLYNI
>A0A371R0F3|diphthine synthase|EC 2.1.1.98|Pyrobaculum aerophilum|TrEMBL
MLSLVGLGPGRGYVTEAAAEAIKNADCVFYEDYTAPLDVEALRRLARGEPIRLTRADLED
HSGRKIFECLKEGKRAVLVTGGDPMLATAHAAILALARRRGYRVEVVPGVSIICAAFSLS
CLSIYKLGGVATVTYPRGGVYSTRPYDLVEQNLQRGLHTLLLLDVREDGRFMPPREGAEV
LLQLEERVGRGLFKEDLPIVVVYKVGWGGSAVYATLGEIARSDLEGPAVFIVPSRLGPVE
KECLEGLSARSSTR
>A0A256K5N9|diphthine synthase|EC 2.1.1.98|Halorubrum ezzemoulense|TrEMBL
MLTFIGLGLCDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>D2RXA1|diphthine synthase|EC 2.1.1.98|Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)|TrEMBL
MLTFIGLGLYDEQSITVEGRDALRNADRAYAEFYTSKLLGATAADLESAHDVDIEVRDRA
GVEQRPDDILEAATSEDVVFLTAGDTMISTTHVDLRLRARDRGIETRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDANREDGLHTVVYLDIKVDHELTDED
EYMTADVGAELLAEEYPDLVGVVVARAGSPDPLVAAGTMSELAEREFGDPLHLLVVPGEC
HPLEADALVELAGADRDALETN
>A0A8J7XJX1|diphthine synthase|EC 2.1.1.98|Theionarchaea archaeon|TrEMBL
MLYLVGLGLQSDLTREGFTTARKCKVYLETYTSFLTVSVQDLERILEKNITVLTREGIEE
TQEFLKEAHTTDVALLVAGDPLVATTHHEIIIEARKRNIRTKVIHNSSIYSGIGETGLQI
YKFGKTVTIPFPQKGFQPTSFYDILQNNRTIGAHTLVLLDIQEDMNKYMNPKGAMEILQG
LGFQEELICVSRLGSHDQNIVYGGIEELLSLDEKYWGLPPHCLVVPSTLHFKEEEYLEAF
RLEVVT
>A0A366MF12|diphthine synthase|EC 2.1.1.98|Methanocorpusculum sp. MCE|TrEMBL
MLTFIGLGLFDEYDVSVRGLDAIKSADTVFLEVYTSVLMGAPIERLEAVYGKKITPLYRE
DVEIHADKILDAAEFENAVFLTAGDSMVATTHSDLRIRAADRNIQTKIIHGASITTAVCG
LSGLQNYRFGKSVSVPFPYGKWFPMTTIEVISANLKENLHTLVFLDIQKDKERYMKISEA
VDLLEEQARRADAKIPLYVGIARAGSPNPVVHAGNAEEMRSFDFGSPLHILIVPAKLHDI
EREYLERFAGLC
>A0A0P8XSM3|diphthine synthase|EC 2.1.1.98|Thermococcus sp. EP1|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIAKKCELLFAEFYTSLLAGTTIEKIEQQIGKPIRVLNR
EDVELNFEKIVLKEAKEKNVAFLTAGDPMVATTHADLRIRAKQRGIESYIIHAPSIYSAI
SITGLHIYKFGKSATVAYPEKNWFPTSHYDVLKENKERGLHTLLFLDIKADQGRYMSANE
AMRILLQIEEMKKEDVFTENTLAIVLARAGSLTPTLKAGYVKELIKEDFGKQPHVLIVPG
KLHIVEAEYLVEFANAPKEILKDV
>A0A1M4MH44|diphthine synthase|EC 2.1.1.98|Methanoculleus chikugoensis|TrEMBL
MLTFVGLGLFDLGDISVKGLEYVRSADAVFLEAYTSRLMGTDVGAMEAFFRKEIRVLGRE
DVEQNPREILDRAAAGRVAFLTGGDPMVSTTHADLRLRAAAAGIETSIIHASSISSAVSG
LSGLQNYRFGKSCSVPFPAKGWFPTAPMEAIAANLAQNLHTLVYLDIQKDRYMRVPEAIA
VLEEMAEKRGIEPPALYVGIARAGSEQPVVAAGTGAKLKETDFGPPLHILAVPAELHPME
REYLETFAGL
>A0A1Z2TP61|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 5-4|TrEMBL
MAIYFIGLGLYDEKDITLKGLETARKCDLVFAEFYTSLLAGTTLDKVEELIGKPIRRLSR
EEVELHFERIVLSEAKEKDVAFLTAGDPMVATTHSDLRIRAKELGIESYVIHAPSIYSAI
AVTGLQIYKFGKSATVAYPEKNWFPTSHYDVIKENMERNLHTMLFLDIKAEQNRYMTANE
AMEILLQVEDMKRENVFTPDTLVVVLARAGSLNPTLKAGYVRDMIREDFGRQPHVMVVPG
RLHIVEAEYLVAFAGAPKEILDGI
>A9A1L4|diphthine synthase|EC 2.1.1.98|Nitrosopumilus maritimus (strain SCM1)|TrEMBL
MLWFVGLGISGFKSIPNEAIDVLAKADIVYLEQFTSPIGKSDLTKIKNATKGEFRPAKRW
LVEDGNEILENAKKKKVVLLSYGDPYIATTHIELRERAIKEKIKTYSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNVIEGNHTVLLLEFNQDKDFFLDPKDALNE
LLETEKGQRRKVISPSTFAIVASRIGFKDQEIVSGKISSLKKRDFGKPPHTVIIPGRLHF
TESDALKVLGECIDEPFDNSEKTRKISVQMIEKYVPMVREALEEVQPYYKDQKEFQVILE
NAELYVKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A7C6FYW2|diphthine synthase|EC 2.1.1.98|Methanobacterium sp|TrEMBL
MLCLVGLGLYDEKDISVNGLEAIKSADVVYAEFYTARLFGGDLKSLESLTGVMINILSRE
EVEEENLLIKQAKEKKVVFLTAGDPLMATTHSDILIEARKKGIKTVIIHASSILSAAPGI
AGLQAYKFGKVTTIPRPEENYFPQSPYEVVSGNKKMGLHTLVLLDIQAHQNYYMTANEGL
EYLIRIENIKKEGLISEDALAVVIARAGSKEPLVRADSVDKLLKEDFGGPLHCIIIPGDL
HFLEAEGLVILGGAPESILEAD
>A0A7M3XXX3|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MMGRRTPCFTMTDGALPAGLWLIGLGPGDLGLMTADAIEHARACEYRFLEGYTATLPDDQ
EQRLESVVGPWERAMRPMVEEPEKILAMAKESSVALLVVGDPMQATTHIDLESHCAEQGI
DYSIIPGISATSLAVSVSGMQSYRFGRQVTLPFAYGDYLPTSPLELIDANYTNNLHTLVL
LDLDPTGMGVDTPQPMNPSQAVDLLQKMFEKLVDAEGSVRESMTTPLAKWNGILLSDLGT
HEQRVVSGDLGDIATIEGGRIHCLILPAEFTGMEREAYERRRG
>A0A662TA25|diphthine synthase|EC 2.1.1.98|Candidatus Geothermarchaeota archaeon|TrEMBL
MVILTLYIIGLGIREETELTEKLISILRRCKYVYWENYTSPATYNLSDIIRILEREVRVL
RREDLEERIEDIIVDAKKENVAILVCGDPLIATTHVNIILEAKRMGIEYRVFHASSILSA
GIGESGLHLYKFGPSGTIVREEKVSNKRNIDILKFNLENGLHTLYFLEYDKDEEYIMPPS
YAIKILSKYAGNILSNYNPYIIILCGIGTQNPYKRALKYNEVIKLLNKLPVDKPCIIIVS
GQLHYMEKEYIEKVLR
>A0A7C7LTA1|diphthine synthase|EC 2.1.1.98|Candidatus Poseidoniales archaeon|TrEMBL
MTLAEVGHGLVLIGTGVGSPTQMSVAGVEYATKSEYRFLEGYTSVLGDTGQQLLETQVGT
IEVLMRGDIENPQRILELAKDELVSLLVVGDPLQATTHIDLLLRCHDEGIPYEVVHAASV
TTLVSGGIGLQNYRFGRQVTLAFPVGDYLPTSPLEMLCESLYLGNHVLVLFDLDPTGSGD
VNPVPMTPEQAVLTLELMAQKLRQDLPPHLDEGEMAADDVRGRLKARAVQELLSVPLRQW
FGILCSDLGTIEKRLRRGSLADISRLQGGEIHCLVIPGELQGLEAEAVDKLILPA
>A0A897MNM6|diphthine synthase|EC 2.1.1.98|Natranaeroarchaeum sulfidigenum|TrEMBL
MLTFVGLGLYDERSITVEGQRALREADRAFAEFYTSKLIGTSAEELEAHHGTEIDVRDRA
GVEQDPEPILDAAASGDAVFLTAGDTMISTTHVDLRLRAHERGIETRVIHGITAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIEANRDADLHTVVYLDIKADREEYMTA
DVGAELLAEEYPDLVGVVVARAGSPEPLVEAAPLSDLAEREFGEPLHLLVIPGELHLLEA
DALCELAGADRDALEIS
>A0A6G2KSG4|diphthine synthase|EC 2.1.1.98|Cenarchaeum sp. SB0673_bin_9|TrEMBL
MLHIVGLGITDDSIPSNIRNIMQNADVVYLETFTSPDINTSEIRRICPKLQMAPRWMVED
GRRILKESEKKDVVLASYGDPLVATTHTDLRVRAVQSDIPVNVVHGPSAITILVGECGLH
HYMMGRMVTVMSEDTLLETPYMASYRNAALGNHTLLLLEYNQDTDFFLGANAALKKLSNA
EKSYRRGVFAPDSYCMVACRIGTKKQLVVSGRVSSLEGYNFGDPPHSIILTGRLHFTECD
AIRALTTCVDNPPEGHTIKSISRQMIEKYTPMIQKSIQNITGYSDGENMVIQNAISYIQD
AQAALEKGQDEVAVLSIGYADGLIDALRMSQGMDPGSLDPKI
>A0A497SYJ0|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLYIVGLGLSDDDITLSCLESVKSADIIYIEDYTNKWLGSASLLERLTGKKIKHISREGV
ESDKLIKEAKARDVALLIPGDPFAATTHFELIIEAAKQNIKYKIVHAPSIFSVIAETGLQ
LYKFGETITIPYSHGNYNPSSWFAKISKNLSNKLHTLILLDIQNGNCMTVREALESIENL
DKNRRIVTKKIVACSKLGTEQRKIVFGSFQKLKKIDFDIPACIIIPGNLHFKEEEALALW
SCG
>A0A2P5K230|diphthine synthase|EC 2.1.1.98|ANME-2 cluster archaeon HR1|TrEMBL
MLTFIGIGLYDEKDISIKGLEAVRAADRVYIEFYTSTLSGTSIEKLQTFYGRRINLLTRE
DIEQNPDWLNYAKTENIVMLTGGDAMVSTTHIDLRLRAIDLGIETTIIHGPSIISAVPGL
TGLQNYRFGKSASIPYPYTSKGKTIISHTPYDIITSNLHTDMHTLIFLDIDPVKGYMTIR
QACELLLTVDSLRKEIDLKGRLAVGVARAGSPDPVVKALPLNKLMDFDFGAPLHILVVPA
QLHFMEAEALVKLAEA
>A0A7C3ACX7|diphthine synthase|EC 2.1.1.98|Candidatus Aenigmarchaeota archaeon|TrEMBL
MTVMLYLIGLGVDFDLGVKALNIVKKADRVYLESYTSPVDFSVIDSYGFNYDVLSREQIE
EEFNVLDAKEKDIVILVPGDPLTATTHISLILEAYEKRVPYKVIHASSVYTAVCETGLQT
YKFGRSTTMPATGERSFYTVIEENMSLGLHTLVLVDPELDSKQAIEMLLSMGFPSDYKIV
LASKLGYDSTIYYGKASDLAADVDKPFCIIIPGKLHFMEQEFLDKVYKYNSVK
>A0A7J2VBJ6|diphthine synthase|EC 2.1.1.98|Desulfurococcaceae archaeon|TrEMBL
MLVFIGLGYSLRHLTREAIDWLGKADVIYIDTYTSLYEDSLENLRNLNPRAVFVMAKRRE
LEGEAIGRVVEEARHKTVAIAVPGDPFIATTHDALLSEAIKQGVEFRVIHGVSILNMAYS
RVGLQSYRFGKMVTLVYPTHFKPLSTIETIYDNLSRGLHTLVLLDLRIEESLAMSIPEAV
QILVELDYKGGLGEQLSIGLARLGWRDEKICAGRLIDLAGYSYPPPPHSLIVTSRLDPVE
KEIFEYWRRQC
>A0A128A4W1|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosotalea devanaterra|TrEMBL
MLWFVGLGISGLEGASANAIQVLKKADMVYFENFTSPIGRTELSKIKKLVRGKMTIAPRW
MVEDGKAILLLAKKKNVVLLAYGDPYVATTHLELRTRAEKDKIKTKTIHAASAITSLIGE
CGLHHYKIGRPVTIMRELPSLSTVYYTIYENMVKGNHSLLILEFDNSSNFFLNPKDALSS
LLETENGQRRNVIDQSTFAIVASRIGSKSQKIISGKLSSLVKVDFGKPPHTIIIPGKLHF
TEHDAIKIFSKCFDEPFDNSSKIQKISDQMLSKYVPKARKALEEVTKMLKDDPSLKPVIE
NAQLYIDDSEKFQRDGQEELAVLSIGYAEGLMDALRLSKGIDPWAQSL
>A0A842LDA1|diphthine synthase|EC 2.1.1.98|Methanobacteriales archaeon|TrEMBL
MLYIIGLGLYDEDDISIKGMKTLKRCDRIFAEFYTAKLKDQKLSTIREKTGKDVKILARE
EIEEDMTPLKYAQGEDVALLVPGDPLVATTHSNLILEARKKNIKTRIIHSSSIFSAAPGL
AGLQIYKFGKTTTIPFPEKNYFPHSPYLTIKDNLEYNAHTLILLDIKAEENRYMSANEGL
EYLLRVEKERKENIIDLNTLAVVLARVGSSDPLIRADLIKRLIVEDFGRPLHCLIIPSTL
HFLEAEYLIEIGGAPPDILK
>A0A4D7HCM9|diphthine synthase|EC 2.1.1.98|Haloprofundus sp. MHR1|TrEMBL
MLTFIGLGLYDERSITVEGREALRSADRAFAEFYTSKLIGTTVEELADHHGVDIDVRDRA
GVERDADEILDAAEDGDAAFLTAGDTMISTTHVDLRLRAHERGIETNVVHGVTAQSAASG
LTGLQNYRFGKATTLPFPYAHGADGTPRSVVDTVEDNRERGLHTLVYLDIKVGYERAGVD
ADDEYMTADFAAGEFARDWDGDALGVVVARAGSPEPVVAADRLSALAEREFGDPLHMLVI
PASLHDLEAEALSAFGGAPAEVVDENTV
>A0A843E9W8|diphthine synthase|EC 2.1.1.98|Methanobrevibacter sp|TrEMBL
MFYLVGLGLFDEKDISLKGVEALKKVDKVYAEFFTSRLFGSNFEKIESIIGKDIIVLDRT
QVEEESIFLEEAKDIDVALITGGDPLIATTHSDFLVECARKGIDFEVIHGSSILSSAPAI
SGLQAYKFGKVTTIPFPDLEYNYFPKSPYIAIEENLKMDMHTLVLLDIQAHNDKYMTVTE
GLENLMTIKDNLDHEGLVNEDTLAIGIARVGSKD
>A0A1W6K2A8|diphthine synthase|EC 2.1.1.98|Acidianus manzaensis|TrEMBL
MSVLYFIGLGLSKKFLTQASVDSIKRADVVYFDSYTSISCDITIDYLKEISGKDIILANR
STLENNSTRILQILDQGKSVAILSIGDSMIATTHVSLAVEAKNRGHEIVVIPGISVQCYI
ISKSMLSSYKFGRAVTLVYPYEGKLDTTTYDVILNNSRSNLHTILFLDIKDGKPMSAKEA
IKYLIQMEEEKQGNIITDNSWLIVGQRLGCDDEEVKSMTVKEALEYNFRDPPHIIIIPSK
NLHYMEVEAIKCLH
>A0A151BGK2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon B25|TrEMBL
MGKLVFVGLGLRGLGGIPLEGLEKARNADRVYLELYTSPIADFSPEKLEELLGRPVSLLR
RVDLEDEGGRKVLEAAGEGCVVFMVPGDPLIATTHVDLKLRALKAGVKVEVVHAASIYSA
APSISGLQIYKFGKTVTIPFPASGYTPETPYEVLKENLSRSLHTLILLDYDAEKGRWMTV
REGLQYLLLVEEKRGEGVARPERLALGLAGVGGADVEIRGGAMGKLVKADFKLKPQTIIV
PGSLHFVEAEALKVLAGVSVEELNFEPPGRP
>A0A2R6M094|diphthine synthase|EC 2.1.1.98|Halobacteriales archaeon SW_7_65_23|TrEMBL
MLSFIGLGLYDERSITLRGRDALESADAAFAEWYTSRLAGTSVDRLEVLHGIEIEVRDRP
GVEQHPEPILDAAEEGHAAFLTAGDTMISTTHVDLRLRAHERGIDTRVIHGTTAQTAASS
LTGLQNYRFGKATTLPFPETHGGVPDSVIETIQANRDRDLHTLVYLDIDGENERFLTGDR
AADLLADPLGDPLGVVVGQAGSDDPTVRADRLSTLADESFGPPLHLLVIPAEPHPLERDA
LVELAGAPRALTDDH
>A0A3M9ZMD0|diphthine synthase|EC 2.1.1.98|Thaumarchaeota archaeon S15|TrEMBL
MLTLVGIGVGGARSMGAGAREAIASARAVYMETFTSPVPAGDVEEVRRAAEEGGAAFRAV
PRWAVEDGGEILRAAASGDVALVCYGDPYVATTHIELRARAAAAGTPTRSVHGASALTSV
VGECGLHQYKVGRTATVTRAEASTPYGVLRENVERGCHTVLLLEYDEDAGAFMAPREALA
ALLAVEGERRELALTRETFAVIASRVGTAGQAIAAGSVDHLMGLDAGEPPHSIVVPGALH
FTEADALRALARCEGEPRSNSETARREAHRMLARYVPMVGAAMREARERGADERVLDCAR
DYVADAEEFLRRGREGQAILCIGYADGLVDALRIGAGLEREDGAPDRG
>J0RYI5|diphthine synthase|EC 2.1.1.98|Methanofollis liminatans DSM 4140|TrEMBL
MLTFIGLGLYDETDISIKGLDRIRRSDYVFLECYTSVLTGTTPEQMTELFGKEVGMLYRE
DVEGHPETFLELAKESDVAFLTAGDPMVSTTHIDLRIRAAAMGIRTEIIHGASIVSAVCG
LTGLQNYRFGKSCSLPFPYGKWAPTTPIEVIEQNIADKLHTLVYLDIQPDRYMRIPEAVR
MLEEMAAARGISIPVYVGVARAGSGSPVVAAGTAAALAGVDFGGPLHILVVPGDLHLMER
EYLETFAGL
>A0A419WRH7|diphthine synthase|EC 2.1.1.98|Halopiger aswanensis|TrEMBL
MLTFIGLGLYDERSITVEGQEALRNADRAYAEFYTSKLIGTTIDDLESYHDVEIEVRDRA
GVEQEPDDILAAAEDEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDENREDGLHTVVYLDIKVGHERAEED
EYMTADRGAELLAEEYPDLVGVVVARAGSPDPLVEAGTMTDLADREFGDPLHLLVIPGDC
HLLEADALVELAGADREQLDIV
>A0A8J8KJ69|diphthine synthase|EC 2.1.1.98|Haloterrigena sp. SYSU A121-1|TrEMBL
MLTFIGLGLYDEQSITVEGRDALRNADRAYAEFYTSKLLGATAADLESAHDVDVEVRDRA
GVEQHPDDILEAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTDTIDANREDGLHTVVYLDIKVDHELTDED
EYMTADVGADLLAEAYPDLVGVVVARAGSPDPLVAAGTVSELADREFGDPLHLLVVPGEC
HALEADALVELADADRDALETH
>M0DQR7|diphthine synthase|EC 2.1.1.98|Halorubrum saccharovorum DSM 1137|TrEMBL
MITFIGLGLYDERSITVEGREALRSADRVFAEFYTSKLVGADVEDLESYHDAEIEVRSRE
GVERDPEAILAAAEEGHAAFLTAGDTMISTTHTDLRLRAEERGIDTRVVHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVIDTIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADEWEDALAVVVARAGAPDSVVAADRLSALADREFGAPLHLLVI
PGDLHHVEAEALAGLAGAPADLVEE
>A0A0F7DBV1|diphthine synthase|EC 2.1.1.98|Geoglobus ahangari|TrEMBL
MTLTFVGLGLWDEKDITLRGIEAVRNADVVYAEFYTSRLSTSVERLERVLGKEIRVLERK
HLEEESRRLVEEAKEKNIVVLVAGDPMIATTHSSIMVEAKARGVEVEIVHNASIVSAIAG
VTGLHIYRFGKIATVSYPYGNVVSRTPLDVIKQNLSINAHTLLLLDLNPEPMTIGYAVEL
LERVDDGTLDHFAVGVARVGGDSVTICDKFYRLKHHDFGDPLHSIVFLAKTIHITEYEFL
REFANAPEELYEIVE
>A0A0K1IRS5|diphthine synthase|EC 2.1.1.98|Haloferax gibbonsii|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPEPILDAAEDDHIAFLTAGDTMISTTHVDLRLRAEERGIETRLVHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRELGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGEPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A842NRN0|diphthine synthase|EC 2.1.1.98|Nitrosopumilus sp|TrEMBL
MLSFVGLGISGFESIPVKGLEIISNADIVYLEQFTSPIGKSDVDKIENAIKGEFIPAKRW
LVEDGKEILEKSKEKNVVLLAYGDPYIATTHIELRARAIELKIETRSIHASSSLTSMIGE
CGLHFYKVGKIATIMSEMKSLTYPYYVIYKNIIEDNHTVLLLEYNQNKDFFLDPKDALKG
LLETEEGQGRKVLTESSYVIVASRIGFKDQAIVSGKISSLAKIDFGKPPHTVIIPGRLHF
TESDALKLFGQCIDEPFDNSEKTEKISKQMMKKYVPMVREALEEIIPYYKNQKEFKVILE
NAELYIEQAEIFLDEGRDENAILSIGYADGLVDALRLAKGLEFKM
>A0A6G3LJL5|diphthine synthase|EC 2.1.1.98|Thermofilum sp|TrEMBL
MLVIAGIGLFDLRDIPLGLLEEVKDASAVFIETYTSVLPGFSVDKLSRLLNRQIIQLVRA
EIEDKGAKIILEKAKNEKVILLVVGNPLLATTHASIIIDAYKLGITVKVIPAASVIDGLI
VSTGLHAYKLGKIVTLVFPEDKELKNYPYTPYQTLSDNLSRGLHTIFLLDIRQEERRYLL
APEAASLLLKIEEKFKENVLDDDTLAIAVARATADNEQVYVGKLSDLVARDLGGPPHTLV
IPGLLHDSEIEFLYYKTGTAIGVFKDWNKKLSARIMQRNT
>S5Z7F5|diphthine synthase|EC 2.1.1.98|Thermofilum adornatum|TrEMBL
MLVIAGIGLFDLRDIPLGLLEEVKDASAVFIETYTSVLPGFSVDKLSRLLNRQIIQLVRA
EIEDKGAKIILEKAKNEKVILLVVGNPLLATTHASIIIDAYRLGITVKVIPAASVIDGLI
VSTGLHAYKLGKIVTLVFPEDKELKNYPYTPYQTLCDNLSRGLHTIFLLDIRQEERRYLL
APEAASLLLKIEEKFKENVLDDDTLAIAVARATADNEQVYVGKLSELAARDLGEPPHTLV
IPGLLHDSEIEFLYYKTGTAIGVFKDWNKKLSARIMQRNT
>A0A1Q7MLW3|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_40CM_3_52_17|TrEMBL
MSVTFVGLGLNDEKGLTVEGVEVARKADAVFAEFYTNLMPGLELKKLELLLGKKIVVLDR
VQLEDENGRRILEAAGKGRVAFLVPGDPMIATTHVSIRLELAKRGVSSRIIHGPSIASAV
CGATGLQSYKFGKTVTMPQESGVPGSLVDGIMDNRKRGLHSLVLLDIRSDLSKQLTVAEA
ALKLVAADPLIENWLGIGVARVGSPDQFVLARRLGGLQREDFGKFPHSLVIPGRLHFVEV
EFLKVFCGAKDTDLESVK
>A0A8E8EXR2|diphthine synthase|EC 2.1.1.98|Halorubrum sp. 2020YC2|TrEMBL
MLTFIGLGLYDERSITVEGREALRQADRVFAEFYTSRLVGADVADLEAYHDVDVEVRDRA
GVEQDPGPVLDAAESGDAAFLTAGDTLISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVLETIEANRERGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADEWADELAVVVARAGSPNAVVAADRLRAIADREFGAPLHLLVI
PGDLHHVEADALVGLAGAPESLVEE
>A0A6A7KFZ9|diphthine synthase|EC 2.1.1.98|Thermococcus sp. 101 C5|TrEMBL
MAIYFIGLGLYDEKDITLKGLEIARKCDLVFAEFYTSLLAGTDIRKIEEQIGKPIRLLNR
EDVELNFERIVLSEAKTKNVAFLTAGDPMVATTHADLRIRAKQMGVESYVIHAPSIYSAV
AITGLQIYKFGKSATVAYPEKNWFPTSHYDTIKENKERGLHTLLFLDIKADKGRYMTANE
AMEILLQVEEKKKEGVFTEDTFVVVLARAGSLNPTLKAGYVRDMMKEDFGKQPHVLIVPG
KLHIVEAEYLVAFANAPKQILNEV
>A0A4D8S524|diphthine synthase|EC 2.1.1.98|Metallosphaera prunae|TrEMBL
MADIYFVGLGLSKRFLTNASLEVLKGSDVIYADIYTSISCDINEKTLREITGKEIIPATR
EVLETKEKEIYKLLDSGKNVAIAVVGDPMIATTHVSLATGARARGHRVSVIPGVSVHCYM
ISRSMLSSYKFGKSVTVTFPVLDKLDYTPYRVIKTNRELGLHTMVYLDLKETGIMTADLA
LNYLKKMESDIGDKVILDDDLVVIGERLGCADERVRAMKVVDALNQKFGAPPHIIIVPSR
NLYEMEVEGLKCLS
>A0A4U5JFD0|diphthine synthase|EC 2.1.1.98|Natronomonas salsuginis|TrEMBL
MLTFVGLGLYDERSITVEGREAVADADRVFAEFYTSKLVGATVEDLESYHDTAIEVRDRP
GVEEDPEPILDAAADGNAVFLTAGDTMISTTHVDLRLRAAERGIDTRVIHGTTAEAAAAS
LTGLQNYRFGKATTLPFAYAHGGDGVPGSVVDTVTDNRDRGLHTLVYLDIKVGIGPKGRD
PDHEEYMTADHAAGRLADELDALGVAVARAGSPNPVVAADQLSALAGRAFGEPLHLLILP
GDLHVIERDALAELAGAPTSALPDPV
>A0A2I0D0J3|diphthine synthase|EC 2.1.1.98|Methanoregula sp|TrEMBL
MLTFIGLGLFDKTDVSEKGLSRIRNADRVYLECYTSRLMGATLPDLEQFYGRQVTPLYRS
AVEQDPDAMLEEAVAKDVVFLCAGDPMVSTTHADLRMRAASRGIPTAIIHAASIASAVCG
ISGLQNYRFGKSCSLPFPQKNWFPTTPLDVIVTNLSLRLHTLVYLDIQDDRYMTVSDAVA
LLEEMVDARKVKIPLYVGIARAGSDLPVVRAGTAEKIRACDFGPPLHILIVPAELHDMER
EYLEMFAGL
>A0A1H9SA50|diphthine synthase|EC 2.1.1.98|Natrinema salaciae|TrEMBL
MLTFIGLGLYDERSITVEGRAALRSADRVYAEFYTSKLIGTTIDDLESAHGVDIEVRDRA
GVEQHPEDMLEAAANEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTATSS
LTGLQNYRFGKATTLPFPYAHGAEGLPASVTETIADNRADGLHTVVYLDIKAEREEYMTA
DVGAELLAEAYPNLVGVVVARAGGPEPLVEAGPMAELADRTFGDPLHLLVVPGACHLLEA
DALVELAGADRDDLEIV
>A0A327GWK1|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon TMED132|TrEMBL
MTAGNSTELPKSGLLLIGMGPGQIGSMTIEARNAAKSADFRRYEAYTALWPADELTKLEE
DIGDIEMVMRPEVESPTELLDLAKNHLVALLIVGDPLQATTHVDIQLQALEAGINCMVFH
GISITTLVTGAVGLSNYRFGRQTTITYPYGGWVATSPLEVIAVNLFQNQHTLALLDLDPT
GAGTGKQVPMQPKDAYDSLGLMKEKLSSTISDMSEESSFDSMKKLAFKEFVANGLDSIKV
VLCADMGTKDEKITYTTVGDLKNTDGGRLNSLIFPAITSEVEEKALLRWQ
>A0A1Y3AG20|diphthine synthase|EC 2.1.1.98|Halorubrum sp. SD612|TrEMBL
MLTFIGLGLCDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE
>A0A3Q9EBK1|diphthine synthase|EC 2.1.1.98|Halorubrum sp. PV6|TrEMBL
MLTFIGLGLYDERSITVKGREALGDADRVFAEFYTSKLVGADVETLEAYHDVEIEVRPRE
GVEQDPEAILAAAEDGDVAFLTAGDTMISTTHTDLRLRAESRGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPASVIETIAANRDRGLHTVVYLDIKVGTGPTGPD
PDHEEYMTADVAAGLLADEWADPLGVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGALHHVEADALAGLAGAPAELLEE
>Q6KZN4|diphthine synthase|EC 2.1.1.98|Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)|TrEMBL
MEMYDVIKKSDLVYFDIYTSISPDKTFEDLIKINANTLKATRDVLENEGPIIERAVTENI
TIVVTGDALSATTHNQIRRSAIEKGIDVNIYENASIITAFPSRTGLFIYRFGSIVSMPFT
SDKFFPLSVYDKIYKNYINNMHTLILLDLKDGRTMPINDALNNLLAMEDKKHKGLIKEDT
LLFAGIKIGSCYEKIYFSNISKMLELDIEDSPASIIIPAELNEIELEFARSFCINVF
>M1Y0Y2|diphthine synthase|EC 2.1.1.98|Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 / 8.8.11)|TrEMBL
MLTFVGLGLYDERSVAADGEAAIADADRVFAEFYTSTLAGATVGELESYHGVEIDVRDRP
DVEEDPEAILEAAESGDAVFLTAGDTMISTTHVDLRLRAADRGIDTRIVHGTTADAAAAS
LSGLQNYRFGKATTLPFPYAHGGDGVPGSVLDTIADNRERGLHTLVYLDIKVGIGPSGPD
PDHEAYMTADHAAGRLAEDLDGIGVVVARAGAPDPLVAADRLEALAGRSFGDPLHLLVVP
GDLHVVERDALVELAGAPPEALPDPV
>A0A2Z4LBJ7|diphthine synthase|EC 2.1.1.98|Methanosphaera sp. BMS|TrEMBL
MLYFIGLGLFSEDDISVKACKALNNVDVIYAEFYTAKLMGGNIDNLISRVDVPFIKLKRE
DVEDRNVVLQEAMDKDVAFVVAGDPLMATTHTELYVEAKNKGIDTRIIHGSSIFSAAPGL
SGLQAYKFGKTTTVPFPDENFFPHSPYDAIKSNLDMGLHTLVLLDIQAHRDRFMTVNEAI
QYLSKVESDRGEGVFTEDSIVIGIAQAGSDNPIVKGGRVGDVVDFDFGSPLHCMIVPGNL
HFVEAEALITLADIPEKLLEQFL
>A0A1D2WAK8|diphthine synthase|EC 2.1.1.98|Methanobacterium sp. A39|TrEMBL
MLYFIGLGLYDEKDISLKGIEALRKADVVYAEFYTANLFGTTLDALKFMIGKDIVVLKRS
EVEEENIILESAKDKNVGFLTAGDPLIATTHTDLMIEAKKRNIETTVIHASSILSAAPGL
AGLQAYKFGKVTTVPFPDKNFFPHSPYTAIKANIEFNAHTLVLLDIRADENRYMTVNEGL
EYLLKVEEERKEGAITEDTIAVGIARAGSDKPFVRADKIKNLIKEDFGGPLHCMIIPGDL
HFMEAEYLVKICGAPEEILEDQ
>L9X8B2|diphthine synthase|EC 2.1.1.98|Natronococcus jeotgali DSM 18795|TrEMBL
MLTFIGLGLYDERSITVEGREALRAADRAYAEFYTSELLGTTVADLESAHDVSIEVRDRA
GVEREPEEMLAAAESEDVAFLTAGDTMISTTHVDLRLRAHDRGIETRVIHGVTAQTAASS
LTGLQNYRFGKATTLPFPYAHGADGLPASVTETIDANRADGLHTVVYLDIKAERGEYMTA
DTGAELLADVYPELVGVVVARAGSPAPLVAAGRMRELAERSFGDPLHLLVVPGECHLLEA
DALVELAGAEEDALDVA
>A0A847TMJ8|diphthine synthase|EC 2.1.1.98|Haloferax alexandrinus|TrEMBL
MLTFIGLGLYDERSVTVEGREALADADRAFAEFYTSHLVGATVEELEAYHDIDIEVRDRA
GVEQDPGPILDAAEDEHVVFLTAGDTMISTTHVDLRLRAEDRGIETRLIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYVHGGDPVPKSVVDSLEANRDLGLHTLVYLDIKVDWEGRRGV
EVDGDQYMTADYAAELFAEHWDGDALGVAVCRAGSPDPVVAADRLSALAERDFGAPLHML
VIPGEVHHVEADALSALGGAPEELFDDEN
>A0A7J3SC95|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLIFVGLGLNGLEDITLSGVKWMRCAEKVYLDLYTSVIPNFSIEILEKNIVGRNVIRVSR
RDVEENYDKILNEAKDKNVVLLVPGDPFVATTHMQLRLAAISKGIETRVVHATSIQSAIC
GETGLFSYKFGRCVTVTFPYGESICETPYDVIKENMRQGLHTLLLLDMDAENMKFMSIAE
AIEILNKIEEKRREKVIKKDTLCVGCARIGSDTQIVKADYINELSKVDFGPPPYSLIIVG
RLHFMEAEALVKLANAPVNVMEGVKCPIMN
>A0A843C974|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MKELVFVGLGLEDENGISIQGLKEVKSAENVFIELYTNLMPNFSLNNFKIISGKQPYILL
RHELEEENGKIILNAAEKGKTVFLVPGDPLIATTHITLRLEAKKRKIQTRIIHGTSIISA
IMGLSGLHNYKFGKTVTIPFPYNFSETPYKVIIQNKKFGLHTLCLLDINKKKEQFLSIND
ALKLLLNIEQKRKQKIVTTKTIVVGLARVGSSSQILKAGRIKQLLDFNFGGPPQSLIFPG
KLHFMEAEALVAFAGAPREIKE
>A0A497MAP7|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MYSLPLVGEGELIFVGFGLGDLGLTVKGLEMVKNADRVYVETYTNYTPDWVVERLEELSG
RRFERVSRKELEELGGAALLETASDSRVVFLVPGDPFMATTHIALRIEAEKKGIKTRVVN
SSSIVAAAAGACGLQIYKFGESATVVFPDGGTVSMKPYDTVLKNLERGLHTLLLLDYRAE
EDRAMTVNYALRLLRSLEKIRGMGVFSDDRLVVGLARLGYENCKVKGGPLKDILNEDFGE
PPHCIVIPGSLHFVEVEALKILADVEETPSKRGVGARSYIPLDRLNRYISGVEKVFRDIR
LLESSRLVDRRDVDKALDWARSYYEDSRAFRDRGDLVSSLVAVAYCEGILEGLRLLNLVE
FKWEGEV
>A0A7C3SRF6|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MLKFIGLGLYDEKGLSILGLEEAKNSDIVFAEFYTSFMPGLSLNRLENLIGKPIQILSRK
DVEERDEEIILKAAKEKDVAFLTPGDPMNATTHIALRVKAEKMGIKTKLIHAASIFSAIA
GATGLQSYKFGRSVSIPIAGKFSISEAPYNVVKTNKSLGLHTLVLLDLDVEAGAYLTVSE
ALRQLLIVEERKKENVINLNSFIIVVARLGGATMDVKSLLVKDALNQDFDGPPFSIVFPG
KLHFMEAEALQVLTGAKKEFLEENLNEKL
>A0A537E4B2|diphthine synthase|EC 2.1.1.98|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVAFIGLGLNDEKGLTIEGLEEARHANSVFAEFYTNTMPGLDRKKLEIVLGKKVIVLSR
VQLEDEQAKPIVEAAERGKVAFLVPGDPMIATTHISIRLELARRGIPSRIIHGPSVTSAV
CGATGLQSYKFGKSVTLPREPGVPGSLLDTVRDNKNRGLHTLLLLDVRPEMAQQLTIGEA
AAKLVAADPTLGNWMGIGVARIGSEDQFVLSAKLGKLQNQDFGSIPHCLVIPGRLHFMEV
AALKAFCRAEDADLEALK
>A0A1V4U6T5|diphthine synthase|EC 2.1.1.98|Methanoregulaceae archaeon PtaB.Bin108|TrEMBL
MLTFIGLGLYDHRDVSVKGLEYIRQASRVFLEGYTSHMKGTTLEEMQTFFGNAITLLTRE
DVEQNPGEILDAASRGNVAFLTGGDPMVSTTHADLRIRAKERGIETAIIHGASISSAVCG
LTGLQNYRFGKSCSLPFPAKNWFPITPIEVIQKNLEAGLHTLVYLDIQEDRCMTVPIAVD
LLEQMAQTAGISIPCYIGVARAGSMNPVVSAGTAEKVRATEFGPPLHILVVPGPLHVMER
EYLTIFGGL
>A0A7C4XJ73|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
MLNIIGIGLRGLESITLGSADLIRSSDEVYLDTYTSILPEGSLGEISRFFNREIIPVGRE
FIEGDSPIIERSRNTTVSLLVSGDGMSATTHKVLERTCISMGISVRVYENASILNVIPGR
LGLYTYKMGPPVSLPFITDKFFPTSVFTKIRRNHSNGMHTIVLLDLKSGRNIEISQAITW
LLEMEISAEGEKFLNDEQVCVVSRASQAGEKILCGSIMSMKSIDFQSPAAIVILSNPDTF
EMENIDSFRVPSEDRNQA
>A0A6B0DKA5|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
EKINDSDEIYLELYTSRIVDMTLDELENLINRKITLLDRKTIESEFLVERSRKMNVSLLV
PGDPIIATTHIGLVISSIQNNVEYEIINGISVQCVVPSILGLQNYKFGRSVSIPFPEYDY
YPESVYNFVLENRKLGLHTLVFLDLRESLEMSALMGIDILLKMESMYRKDAIDKNTIIAV
ISKAGSEKQKAIADKIERIKERDLGPTPHIMVIIGSLHYMELEALKKFASFPENENINLL
>A0A3M1RDE0|diphthine synthase|EC 2.1.1.98|Euryarchaeota archaeon|TrEMBL
KGYAPESFYDVVKENRSRGLHTLLFLDIKERPMTVNEAISTLLGIERRRGDGVVRGDTLM
VGLGCVGSENPTIIAGKASDLLKKDFGPAPHVLIVPGELHFMEEEYLKEFGGL
>A0A1V4V583|diphthine synthase|EC 2.1.1.98|Methanosaeta sp. PtaB.Bin005|TrEMBL
MLFLDIQMEPVERYMTANEGTALLMEMEANAGESGLMEAIAVGIARAGAPDASVKADLLP
RLQGYSLGGPLHILIIPARLHFMEAEALRILADAPADAVQC
>A0A7K3YE41|diphthine synthase|EC 2.1.1.98|Methanomicrobiales archaeon|TrEMBL
KSCSVPFPAKGWFPTTPIETVAENLALNLHTLVYLDIQNDRYMRIPEAIAVLEEMAQKRG
IEPPALYVGVARAGSERPVVRAGTGAVLKEVDFGPPLHILAVPADLHPMEREYLETFAGL
>A0A256XBI0|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon ex4572_64|TrEMBL
MGKLYLIGLGIYPTYLTLQGVEALKSCDFVFLEDYTSPTPSWCLEYIKNVSGKNVVKVSR
KDLEDNEGRIIFEKLEKGCKVALLVPGDPAIATTHNVLRIEACRRGHEVTVIHGVSILSS
VISLVGLSPYRFGPAVTITYPRMNVYSLRPYEVVKDNLERNLHTLLLLDVSDDGKFMTIS
EALKILRALEEKIRGKIFTEDRVIIGIARVGFPDTKVHVDTLTGLENYDFGEPPHVMIIP
AKLHFIEYEVLVHVHKCSDKLLRELLMK
>A0A0Q1F8P7|diphthine synthase|EC 2.1.1.98|Methanoculleus sp. SDB|TrEMBL
MLTFVGLGLYDEEDISLKGLSCVKKAQHVFLESYTSQLMGTKICEMEEIYGKKIRVMSRE
DVEQNTEMILERARDEDAVLLTGGDPMVSTTHADLRIRAAREGIETQIIHGASISSAVCG
MSGLQNYRFGKSCSIPFPAKGWFPLTPIETMVANREMNLHTLFYLDIQQDRFMTIPEAID
LIGEMAARKGWESPSLYVGIARAGSSDPVVAAGSAKEMGEVDFGPPLHVLIVPAELHVIE
REYLEMFAGL
>A0A6C0UEA9|diphthine synthase|EC 2.1.1.98|Halogeometricum borinquense|TrEMBL
MLTFIGLGLYDERSITVEGREALADADRAFAEFYTSHLVGATVEDLESYHDIDVAVRDRA
GVEQHPEDILDAAEDEHVVFLTAGDTMISTTHVDLRLRAVERGIDTRVIHGVTAQSAASG
LTGLQNYRFGKAVTLPFPYAHGADGVPQSVIDSIEANRERGLHTLVYLDIKADRDEYMSG
DYAAEMLADGWEDVLGIVVARAGSENPLVAADRLSELAERDFGDPLHMLVIPGDVHHVEA
DALRTLGGASDEVLSENEV
>A0A7C5XH06|diphthine synthase|EC 2.1.1.98|Vulcanisaeta sp|TrEMBL
MGKKNPTLYLVGLGLSPGNLTIDALNIIRSVDKVFMETYTSKAPGELIKQIMGIRHDVVF
LSREDLEDRSGNAIMSELSKGRNAALLVIGDPMMATAHAAILVIAKRLGFEVKVINSVSI
VCAILSQLGLSPYKLGPIATITYPRMGILSMRAYELLNDNLRRGLHTILLLDIKDGNEFM
SAGEAIDLLRKMEENGKLGIINNDLLVIYAARIGWENQSIVVSTISNVPSLGETPHTIII
PGLLNPVEIDYLTYVLNADKDLVLKHQRWVNKLMNGN
>A0A1H3VLU1|diphthine synthase|EC 2.1.1.98|Haloplanus vescus|TrEMBL
MLTFVGLGLYDERSITVEGRDALRAADRAFAEFYTSRLVGTSVESLEAHHDVDIEVRDRA
GVEQHPEPILDAAESEDVVFLTAGDSMISTTHVDLRLRAMERGIDTRVVHGVSASSAASG
LTGLQNYRFGKAVTLPFPRAHGADGVPASVVESVDANRERGLHTLVYLDIKVDDGRGTDA
GETFMTADVAAGLLAEEWPDRLAVAVARAGSPNPVVDADRLSALATRDFGDPLHMLVIPG
DLHHVEVDALETLGGAPAELLDDASG
>A0A7U3GP80|diphthine synthase|EC 2.1.1.98|Candidatus Micrarchaeum sp|TrEMBL
MLYLIGLGIGERDITQAGIEAIKNSEIIILDGYTAFVDPKKLKFISSISKREIQRAGRSE
LEEGVSKIISEAKLRNVSIITNGDPMLATTHKTILVEAGKQGLAFKVIHSTSIFSVAIAE
SGLDFYRFGPTCTVPRWSEHYKPVSFYETVSANISGNRHSMILLDYDNEKGMSIRIEEAI
AIMSKAEEHYKLGVFAKDREIMALCDVGTEKQKIVFKKIADIKTDADYRMATLIMPAKLS
EIETEYIKQISMV
>A0A1Y3GG25|diphthine synthase|EC 2.1.1.98|Methanonatronarchaeum thermophilum|TrEMBL
MSLVFIGLGLFDVKDMSVKGLERARECDRLFAEFYTSRLMGSSVDEIEEFIGMEVEVLGR
DVVEGSDLILDCAEECRVGFLVAGDSMIATTHNDIRLRALERGIGTEIVHAASIFTAAPG
LAGLQNYKFGRSATIAFPYNGRVPRSGYEAVRENRERGLHTLLFLDIKEDGFMSPVEGFE
CLLEVEEEVGDGVVDLDLPVVVVGRAGSGDPEVCAGRLGSLLDAVFGEPLHILIVPGDLH
FLEEEALEMFGLD
>G7WN57|diphthine synthase|EC 2.1.1.98|Methanosaeta harundinacea (strain 6Ac)|TrEMBL
MLTFVGLGLYDERDVSVKGLQTIRDSDLVYAEFYTSRLMGATPEKLAQLYGREVKVLTRE
EVEVSPEGWLGRAKEEKVAFLVGGDPMISTTHLDLRLRALRMGIETRIVHSSSIVTAVSG
MTGLQNYRFGRSTSIPYPYVAGGRRIVAMSPRDVVVDNLARDLHTLLFLDIQPERYMTAG
EGAALLLEMEEEACGDRFNSSLGVGVARAGSEDAVVVADWLRKLVDRDLGGPLQILVVPG
RLHFMEAEALVALAGAPPEILEMAEP
>A0A0P8A7Z2|diphthine synthase|EC 2.1.1.98|Candidatus Methanoperedens sp. BLZ1|TrEMBL
MLTFIGLGLYDEKDITVKGFDAVKKADAVYAEFYTSNLIGTSIEKIEKFYGKKLIILSRE
EVELEPVWLSRAIKENVVFLSGGDAMVATTHIDLRLRAKDLGIESAIIHAPSIYSAVSGL
SGLQNYRFGKSTTIPFPYTRNEKTIISEAPYDTIKMNRKNDLHTIVFLDIDREKGFMDIR
KAVSLLLEMEERRGEGVLVNALAIGIARAGSPSPVVHSDYLEKIKEYDFGGPLHTLLIPA
SLHFIEAEALVKLCGAPPDILI
>A0A842NZ99|diphthine synthase|EC 2.1.1.98|DPANN group archaeon|TrEMBL
MTLYMIGIGLTDEEDITIKGLKAIKEADYVFLECYTSRLQVVMKRLEKFYKKKIILADRD
LVEKKADNILDKAKNKEVAFLVVGDVFGATTHTDLFLRAKKKGIKVEIIHNASILTAVGL
TGLELYKFGKTTSIPYHEKSFKPETAYDVIEKNRKAGLHTLILLDIKPNRNMSVNEAIKI
LLEIENKRKEKVFTKNTMVLGCARLGGDYKIKYGKASEIGKEDFGKPLHCLIVPGKLHFV
EKEALENWK
>A0A842NQX9|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MTLYMIGIGLNDEKDITLKGLEAVKKASYVFLENYTSKLQVPVEKLQSFYGKKIVLADRN
MVEKKADIILDKAVENEVAFLVVGDVFGATTHTDLFLRAKEKKIKVNIINNASILNSIGI
VGLELYKFGKTTSLPYPEDNFKPETAYDVIKSNQEAGLHTLVLLDIKPDRNMTVNEAIKI
LLEIEHKRKEKVFTKDVKIVGCARIGGDYKIKYGTASELEKEDFGEPLHCIIIPGKLHFV
EEEVLETWK
>A0A7C1DQD7|diphthine synthase|EC 2.1.1.98|archaeon|TrEMBL
MLYLVGMGLEPGDMTLKGREAVLKAGKVFIETYTSMPYDIGDLQKEITSVDREFVEKGDL
LELAGTADVVLLIPGDPLFATTHISLMKEARDKAIPLQVCHAPSVINTLSHTGLSPYKFG
RIITLSKPFPSDREKLEANLKAGLHTLCLLDPIISLSDGLRVLQDFGVTQKVVACQQLGM
KTQTIHYGTITDLLPLSFSKKPCCLLVPADLHFFEEEFLNQFIHNKSC
>A0A662UEY3|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MPNKVHAPKISCEEALCAFISSQESSSIHEINASVIDLLFLVGLGLYLDLIPLRSLVALA
RCDKIIIDAYTSGPKYVVEELLKILKSTGKDVVLAQRFMLEGEGIESIVWESQDKDVCVA
VVGDPMIATTHNALAVEAAASGIRAVVVPAPSIQCCAIGALGLLSYKMGKSVTVVSPKNG
VVYEYPYEVIKSNLERGLHTLLLLEMDLERGYIMTPCEALKILFSIEQKRNEGVLEEQTR
VVILSSIGTPSHRVCVRTLGELLQKCDNCGDPPYSIVILSKKLHPLEEEALKYAERGLLN
MVPIEGSREVLEQVANILFR
>A0A662J2Z2|diphthine synthase|EC 2.1.1.98|Thermoprotei archaeon|TrEMBL
MRWLQLAELIFVGVGLTGLGLTIEGLRAAREADEVFADSYTSLLPEGSLEQLEEVIGRSV
KPLSRGDLEGEGALKLVELARDKRVALLVAGDPFIATTHVALRVEAFKRGVKTSYIPSAS
IQSVIPGLTGLSSYKFGRSATVVYPDKGLNHAAYEAVRDNQLRGLHTLLYLDLEVERSRA
MTISQALQLLLEVEEERREGVIDGEKLVVGVARACWPSCLVKALRVREALSFDFGPPPHV
LVFPGSLHFMEVEALKTLASLEV
>A0A5E4KV31|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLTFIGLGLYDKTDITVKGLEAVRKSDIVYAEFYTSHLSGTTVGELEKFYGKKIIVLARE
DVEQAPTWLSQAKDKDVVFLTGGDAMVATTHIDLRLRAKDMGIDTAIIHAPSNSSAVSGL
SGLQNYRFGKSTTIPFPYERKNKVILSEAPYDVIKLNKNNNLHTLVFLDIIEPAKRFIDI
GTGISILLELEDKRGEGLLVNALGVGIARAGSTSPIVHADYLAELKKYEFGAPLHILIIP
ARLHFIEAEALVKLCGAPSEIMN
>A0A5E4HYG9|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MEKKERAKQAGPGAGKGGPVGPLFLVGLGLCDEQDVSARSIELLRTCTGLFAESYTNLMR
EGTLRRLEEKIGRKIKPLGREEVESEKIILDACSLGPTALLVPGDPMTATTHSSLITAAK
EKGIEAHILHASSIFTAAPGAAGLQIYKMGKTATITYWRKNYEPAAFIDIVAENLARGAH
TLCLLDIDPEMGCMKPSQALEIMEKAQEKRKKENPALAPVLSPATPLFVLWHVGWPDQKI
WAGKKEHYPYSGRPQKEPGSGPAASAPSREPDGPAVILIAGKMHFAEEENWKSLSR
>A0A5E4HIB8|diphthine synthase|EC 2.1.1.98|uncultured archaeon|TrEMBL
MLTFIGLGLYDEKDITVKGLEAVKNADAVYAEFYTSNLIGTSIEKIEKFYGKKLIILTRE
EVELEPVWLSRSINENVVFLSGGDAMVATTHIDLRLRAKDLGIESAIIHAPSIYSAVSGL
SGLQNYRFGKSTTIPFPYTRNEKTIISEAPYDTIKMNRKNDLHTIVFLDIDREKGFMDIR
KAVSLLLEMEERRGEGVLVNALAIGIARAGSPSPTVHSDYLEKIKEYDFGGPLHTLLIPA
SLHFIEAEALVKLCDAPADILI
>A0A7C6EJB9|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MALYLVGLGLGSSGYLTRRAMEVIKRSDKVYLDTYTSFFEPGLIEELRTILGSRLIEADR
RLLEEGVSRIVEEAGEMDVAILIPGDPLIATTHISIIIEAARRGVEHHVIHGVSACSALI
SASCLQAYKFGKIVTIPKSGIGVETCYRAILENMERGLHTLILLDTADGGLDIPSAIRML
MRVEDEVGMGLITPERLVVCLARIGFGDEFRWAGSLAEALEKSYPPPPHSMIFPGSLHFS
EAEALETLLGASPKAIEQHKLPWSIWQRLQKYIANVENALRSLELVDQSSEVREVLDLVD
RYLDDSRRFLSGGRSFDSLATISYAEGLLDCLRMLDRVRFSWGLRRD
>A0A7C4JM42|diphthine synthase|EC 2.1.1.98|Nitrososphaeria archaeon|TrEMBL
MALYLIGLGLGSLDYTSLKAIREIMKCHIAYLDTYTGLISEELVDWLRKKLDGRLKLACR
RDLEDNLEKIVEEARNIDVAILVPGDPLIATTHMSLLVEASRRRTPYKIVHGISIYSAAV
SITGLHVYKFGKTTTLPLIGDPAETYMIIKENQERGLHTMILLDTADGGLTIPNALRRLL
EAEDRLNQGILGEDTLAIGLSRVGLEDQYIKVGMVKELISVNYPPPPHALIFPGELHFME
VEALSKMYNISEEVVRRHKPARYEKERIRRYIVKTREVMENLKMMKPCKKVDKILEIASS
YLEDAERFWSSGELFNALGAITYAEGLLDSLRMMSLIDFQWP
>A0A564Q0I4|diphthine synthase|EC 2.1.1.98|Candidatus Methanolliviera sp. GoM_oil|TrEMBL
MLTFVGLGLYDEKDISLKGLCAVKNSNYVFAEFYTSRLMGIDIKGLEKFYGKDIHELKRE
DVEIHAEKIIEKAKRDDVCLLCGGDPMMATTHVDLRMRAEDAGVETKIIHGSSIQTAAIG
ICGLQNYKFGRSSTIARPYKDKIPETPYDVLKNNLKNNLHTLFFLDLSEDLSEAPMTIRE
GLEILLNIQERRLEEILDIGIGIARAGSEEMEVKADFIEDLMEYNFGPPLHLLIIPAKLH
FMEAEALVKFARGPKEILER
>A0A7V0SRM7|diphthine synthase|EC 2.1.1.98|Bacteroidetes bacterium|TrEMBL
MGKGSLTFIGLGLYDEKDISLKGFEEIKKCDKVFAEFYTAKLVGTDIKKIEKTIGKNIDV
LTREQTENGDVIINASEKQKVAFLTAGDPMTATTHVDLRIRAMKKGIETQVIHGSSIVTA
VSGLLGLQNYKFGRTTTIAYPEGDYFPTSPYDVIKENKKIGLHTLILLDIQADKNKFMTA
NEGLKFLLDMENKVGNSVLSKDTVACVVARAGSKKPIARADKIEKLINLEFGPPLHSLVI
PGKLHFMEIDGLETLAQLPAYLGEKLQKT
>A0A0D5C209|diphthine synthase|EC 2.1.1.98|Nitrosopumilus adriaticus|TrEMBL
MLWFVGLGISGFKSIPNEAIDILSKADIVYLEQFTSPIGKSDLTKIKNATKGEFKPAKRW
LVEDGNEILKNSKKKKVVLLSYGDPYIATTHIELRTRAIEEKIKTHSIHASSSLTSMIGE
CGLHFYKVGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKDFFLDPKDALDG
LLETEKGQKRNVISSDSYAIIASRIGFKDQLIISGKISSLKKKDFGKPPHTVIIPGRLHF
TESDALKILGQCIDEPFDNSEKTKKISKQMMEKYVPMVREALEEIEPHYKNQKEFQVILE
NAELYIKDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLDPKM
>A0A7C4TKW8|diphthine synthase|EC 2.1.1.98|Archaeoglobus sp|TrEMBL
MLTLVGLGLHDYKDITLRGLEAVRDAEEVYLDTYTSKISCSLEDLQEFFGKEIREAKRSD
LEEGSRKIIEMAKEKKVAILVPGDPTIATTHVSLLLEAKRSGVKTMVINNASIINAICSL
TGLQNYRFGRSATVSWHRSKAFIDTIKANLSIDAHTLLFLDLNPPMTIKEAVERILSLES
SFAEHFAVGIARAGSENAVVKCDELEKMRYFDFGDPLHTLVILARRIHVMEYECLRYFAS
APEGLKEWVL
>A0A832G312|diphthine synthase|EC 2.1.1.98|Archaeoglobus sp|TrEMBL
MLTLIGLGLGDEKDITIRGLEAVKDADVVYAEFYTSKIFASLEALRKFLGKEIRLLSRED
LEERVGSLIEETKRKKVAILVAGDPTIATTHVAILLEAKKKGIETRVINNASIINAVCSL
TGLQNYRFGKSATVSWHRSRAFIDVIKANLSIDAHTLLFLDLNPPMRICDAIERILELEK
EFENHFAVGIARAGSESAVVKCDRLKSLLDFDFGDPLHTLVILARKLHFMEYECLRFFAS
APEDLKEWIT
>W9DTF1|diphthine synthase|EC 2.1.1.98|Methanolobus tindarius DSM 2278|TrEMBL
MLTFIGLGLFDEKDISLKGLEAIKNADMVFAEFYTSRLMGSSLEELESLYGKKVNLLSRE
DVEISPDWLAEAKDKNVAFLTGGDTMVSTTHVDLRLRAKNLGIETKLIHGSSIASAICGL
SCLQNYRFGKASTIPHPFTSSRGVTVISETPYDTIKLNKKHNMHTLVFLDIDKDKGYMTV
NQALSLLLQVEEKRGESIMENAIAVGIARAGSEAPVVKAGYAHALKDEDFGEPLHILVIP
ASLHFIEAEALVELLGAPAEILEGLDD
>A0A662JYB6|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
EKDISLKGIELVKECDKIFAEFYTSVLTDDCIEKLEEMIGKKIEVLNREEVEDGRVILEH
AMDKKVAFLVGGDPLSATTHVDLRIRAKKQGVDTKIIHGSSIFTAIPGLLGLQHYKFGRV
TTLMFPHGDFFPKSPYEIIYENKSRGLHTLVLLDIDRENNRFMSANEGMKLLFDMEESLG
KNLINDNLLVCVVARAGSDNPVVKAGRIKRLIREDFGSPLHTLVVPGNLHFMEVEALISF
AGLEKDELG
>A0A662KL67|diphthine synthase|EC 2.1.1.98|Thermoplasmata archaeon|TrEMBL
MSGELIFIGMGLGKGDLTIKALNILRKCDVVFCELYTSKLSDYQIDDLKRLIGKEINVLG
RKEVEEGDTLIKNALERKVAFLVVGDPMVATTHVSLRIEAEKKGIKTKVINGVSVITAVP
SALGLQHYKFGRTTTLAYPEDEYFPLSPYYVIKENLDRGLHTLVLLDINREKGKLMTVRE
GIDLLFDMEKKAGEGVIRDGTLMCGVARAGAEDCIARAAPARILRGIDFGDTPHTLVIPG
NLHFVEEEALEIFAGYRKMR
>A0A1Q7MA84|diphthine synthase|EC 2.1.1.98|Crenarchaeota archaeon 13_1_40CM_3_52_4|TrEMBL
MSLTFIGLGLNDERGITLEGLEEARRADAAYAEFYTNLMPNLDLRRLEQEIGKKVEVLSR
TQLEDEGGQELLRAASKERVVFLVPGDPMIATTHVSLRLSLARMGIASRVVHAPSVVSAV
CGATGLQSYKFGKSITVPRDQPFPRSVLETISDNNDRGLHTLILLDVQAGETSQMTIRDA
LAKMTVADHRLETRLAVGVARLGSRDEKVKASRMKTLTNEDFGKGPHSIIVVGRLHFMEA
EALKLLCGADAKDLSELT
>A0A7C0Z0J2|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MGELIFVGLGLWSEKDITIAGKEAAGTCDKVFAEFYTSMLGVPEEKIEEVIGRPIEVLSR
EEVEDGNAILDEAADKKVCLLTGGDPMTATTHIDLRLRAIERGIDTKVVHGISIMTASAG
LLGLQSYKFGRTTTLAFPEGDYFPTSPYGVIKENMERGLHTLVLLDIGKKLMTANEGIEL
LMEMEERERGGVIGKKTLMAVVARASSPSPVAKAGYAHELVKENFGPPLHCIVVPGKLHF
MEAKALVMLADAPEEIMK
>A0A842MKC8|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MLSFIGLGLWDEKDITLKGLEEARKCDKIFAEFYTSKMGVEIEKIEALIGKKVHVLSRQE
VEDGRILIEEAKKHRVAFLVPGDPMEATTHVELRIRAIEEGIETKIIHGVSIISASASFA
GLQAYKFGRVISIAKPSKGYFPLSPYENLVENIKAGLHSLLLLDIGMRVNEAMEIILEME
RIKKEKIIDENSLIVVIARISSQDAIARAGKIKDLINEDFGKPPHSIIVPGKMHFMEAKA
LIKIANAPEKIIKERGKDYGATGVGSTHSGL
>A0A7J2J9D6|diphthine synthase|EC 2.1.1.98|Thermoplasmatales archaeon|TrEMBL
MSGELIFIGMGLGKGDLTMKALNVLRRCDVIFCELYTSKPSDYEIEDLERLVGKKINVLE
RREVEDGSILIENALEKKVAFLVVGDPMVATTHVSLRIEAEKRRIKTKVINGVSVITVVP
SILGLQHYKFGRTTTLAYPENEYFPLSPYYVIKENLDRGLHTLVLLDIDREKGKLMTIKE
GIDLLFGMEEKAKGGIIKEDTLMCGVARAGSEDCIARAAPAKILRGIDFGDTPHTLVIPG
NLHFVEEEALEVFAGYRKMR
>A0A842LKX5|diphthine synthase|EC 2.1.1.98|Methanomassiliicoccales archaeon|TrEMBL
MGELIFVGLGLAGSDDLTIQALEAIKKSDIVFAEFYTSRLIDFNVEDLEMKIGKKIMILT
REEVESGKEVIDAARQHRVSFLTAGDPMTATTHLDLRLRASESGISTRLIHGVSIYTACA
SAFGLQHYKFGRTVTLPFQEKNYHPSSPYEHLLENKKMGLHTLILLDIRVAEGKYMTAAD
GVKWLLDMEERIGKGLIDERTLLCAAARVGSRTEKIVAGYPQNILNEDMGPPLHTLIMPG
KLHFMEARALVEFAGAPKQILDSL
>A0A661IAD5|diphthine synthase|EC 2.1.1.98|Deltaproteobacteria bacterium|TrEMBL
MGRLVFIGAGLMGGRWLTLKGLQRAKEVDHLFGEFYTSYLGMSGIEDLKREIGREIVLLT
REELEMGEKVFDALEEGDVGLIVGGDPMAATTHVELRLEAERRGHETEIVYGVSILVAAP
SAMGLQHYKFGMFVIVPCFSESFALKSVLDVIDGNLKEGLHTLLLLDLKEDGGFMTVSES
LKTLKYLEERHRKGVIDDNTLVVGGARIGDRTEYIKGGRLRDLLEVDFGPPVHVVVIPGR
LHFVEEEALMKIASVKEEEISHWRKRIDEKYKGLIPS
>S2E175|diphthine synthase|EC 2.1.1.98|Candidatus Nitrosarchaeum limnium BG20|TrEMBL
MLWFVGLGISGSKSIPVEALEVLSKADIVYFEQFTSPIGKADVLKIKKMTNGELKEGKRW
LVEDGNEILKHAKTKKVVLLSYGDPYIATTHIELRTRAIQEKIKTHSIHASSSLTSMIGE
CGLHFYKIGRIATIMSEMKSLTTPYYVIYKNIIEGNHTVLLLEYNQDKKFFMDPKDALTG
LIETEKGQKRNVIDLSTYAIVASRIGFKDQSITSGKISSLKKIDFGKPPHTIIIPGRLHF
TESDALKILAKCLDEPHDNSEKTKKISEQMMKKYVPMVREALEEIIPYYKDQKEFKVILD
NAELYIQDAEKFLEDGQDEVAILSIGYADGLVDALRLAKGLEPKM
>A0A4U7CFN0|diphthine synthase|EC 2.1.1.98|Halorubrum sp. CGM4_25_10-8A|TrEMBL
MLTFIGLGLYDERSVTVEGREALRAADRVFAEFYTSRLVGADVADLEAHHGVDVEVRDRA
GVEQDPEPILAAAESGDAAFCTAGDTMISTTHTDLRLRAEERGIDTRVIHGVTAQSAASS
LTGLQNYRFGKATTLPFPYAHGGDDVPGSVVETIEANRERGLHTVVYLDIKVGTGPAGPD
PDHEEYMTADVAAGLLAEEWADELAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVI
PGDLHHVEADALVGLAGAPESLVDE