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BRENDA support

Statistics (07.2022)

Increase in the data content of BRENDA in the last years

07.2007
07.2008 - 01.2022
07.2022
Increase from 07.2007 to 07.2022
ACTIVATING COMPOUNDS*
18466
38982
20516 (111%)
APPLICATIONS*
29352
29352
CAS REGISTRY NUMBERS*
4517
4517
CLONED*
72561
72561
COFACTORS*
57164
57164
CRYSTALLIZATIONS*
18870
18870
EC CLASSES
4762
8332
3570 (75%)
ENGINEERING/MUTATIONS*
23234
118627
95393 (411%)
ENZYME SYNONYMS
53389
334210
280821 (526%)
EXPRESSION*
12719
12719
GENERAL INFORMATION*
79825
79825
GENERAL STABILITIES*
8770
8770
IC50 VALUES*
0
68626
68626
INHIBITORS*
112470
294777
182307 (162%)
KCAT/KM VALUES*
37244
37244
KI VALUES*
15736
45904
30168 (192%)
KM VALUES*
79431
175202
95771 (121%)
LIGAND 2D STRUCTURES
38488
159192
120704 (314%)
LIGANDS*
764282
2636836
1872554 (245%)
LOCALIZATION*
19011
67476
48465 (255%)
METALS AND IONS*
67065
67065
NATURAL SUBSTRATES OF ENZYMATIC REACTIONS*
51123
272225
221102 (432%)
ORGANIC SOLVENT STABILITIES*
3591
3591
ORGANISM
15921682
15921682
OXIDATION STABILITIES*
963
963
pH OPTIMA*
58169
58169
pH RANGES*
12992
12992
pH STABILITIES*
8742
8742
pI VALUES*
2060
6975
4915 (239%)
POSTTRANSLATIONAL MODIFICATIONS*
12197
12197
PURIFICATIONS*
65947
65947
REACTION TYPES*
14362
14362
REACTIONS
21665
21665
REFERENCE CITATIONS
108887
512827
403940 (371%)
REFERENCES
68366
165032
96666 (141%)
RENATURED*
1396
1396
SEQUENCES
283138
32864650
32581512 (11507%)
SOURCE TISSUE*
44110
169727
125617 (285%)
SPECIFIC ACTIVITIES*
59846
59846
STORAGE STABILITIES*
11383
11383
SUBSTRATES AND PRODUCTS
517964
517964
SUBUNITS*
72637
72637
TEMPERATURE OPTIMA*
41384
41384
TEMPERATURE RANGES*
6540
6540
TEMPERATURE STABILITIES*
26849
26849
TURNOVER NUMBERS*
85482
85482
* = The numbers denote the enzyme-organism-(protein-)commentary-reference-specific occurrences. For kinetic values (Km, Ki, kcat) and ligand-specific fields (Inhibitors, Activating Compounds, Ligands) the corresponding enzyme ligand is also taken into account.
For example, when the identical pI (isoelectric point) was measured for different enzymes or the identical enzyme from different organisms the information is included for each EC number and organism-specific enzyme isoform, respectively.