Statistics (07.2021)

Increase in the data content of BRENDA in the last years

07.2019
01.2020 - 01.2021
07.2021
Increase from 07.2019 to 07.2021
ACTIVATING COMPOUNDS*
33098
37955
4857 (15%)
APPLICATIONS*
23214
27775
4561 (20%)
CAS REGISTRY NUMBERS*
4545
4525
-20 (-0%)
CLONED*
54950
67863
12913 (23%)
COFACTORS*
33893
53171
19278 (57%)
CRYSTALLIZATIONS*
15304
18150
2846 (19%)
EC CLASSES
7867
8197
330 (4%)
ENGINEERING/MUTATIONS*
97713
113179
15466 (16%)
ENZYME SYNONYMS
215234
316028
100794 (47%)
EXPRESSION*
9104
11412
2308 (25%)
GENERAL INFORMATION*
47575
68164
20589 (43%)
GENERAL STABILITIES*
8107
8672
565 (7%)
IC50 VALUES*
57226
66018
8792 (15%)
INHIBITORS*
253624
288797
35173 (14%)
KCAT/KM VALUES*
28050
33818
5768 (21%)
KI VALUES*
41593
44914
3321 (8%)
KM VALUES*
156474
169393
12919 (8%)
LIGAND 2D STRUCTURES
140194
156376
16182 (12%)
LIGANDS*
1787195
2500586
713391 (40%)
LOCALIZATION*
42920
62781
19861 (46%)
METALS AND IONS*
50800
64319
13519 (27%)
NATURAL SUBSTRATES OF ENZYMATIC REACTIONS*
143388
161838
18450 (13%)
ORGANIC SOLVENT STABILITIES*
3073
3459
386 (13%)
ORGANISM
279845
15124990
14845145 (5305%)
OXIDATION STABILITIES*
866
949
83 (10%)
pH OPTIMA*
51804
55746
3942 (8%)
pH RANGES*
11638
12644
1006 (9%)
pH STABILITIES*
7827
8565
738 (9%)
pI VALUES*
5876
6707
831 (14%)
POSTTRANSLATIONAL MODIFICATIONS*
9337
11640
2303 (25%)
PURIFICATIONS*
48759
63594
14835 (30%)
REACTION TYPES*
11168
13984
2816 (25%)
REACTIONS
18998
22363
3365 (18%)
REFERENCE CITATIONS
232086
253896
21810 (9%)
REFERENCES
150701
161495
10794 (7%)
RENATURED*
1214
1357
143 (12%)
SEQUENCES
13959301
30206252
16246951 (116%)
SOURCE TISSUE*
112238
157207
44969 (40%)
SPECIFIC ACTIVITIES*
54444
58563
4119 (8%)
STORAGE STABILITIES*
10876
11257
381 (4%)
SUBSTRATES AND PRODUCTS
451755
492908
41153 (9%)
SUBUNITS*
54794
69147
14353 (26%)
TEMPERATURE OPTIMA*
35930
39287
3357 (9%)
TEMPERATURE RANGES*
5487
6329
842 (15%)
TEMPERATURE STABILITIES*
23438
26120
2682 (11%)
TURNOVER NUMBERS*
73620
81563
7943 (11%)
* = The numbers denote the enzyme-organism-(protein-)commentary-reference-specific occurrences. For kinetic values (Km, Ki, kcat) and ligand-specific fields (Inhibitors, Activating Compounds, Ligands) the corresponding enzyme ligand is also taken into account.
For example, when the identical pI (isoelectric point) was measured for different enzymes or the identical enzyme from different organisms the information is included for each EC number and organism-specific enzyme isoform, respectively.