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BRENDA support

Statistics (01.2023)

Increase in the data content of BRENDA in the last years

07.2007
07.2008 - 07.2022
01.2023
Increase from 07.2007 to 01.2023
ACTIVATING COMPOUNDS*
18466
38623
20157 (109%)
APPLICATIONS*
29398
29398
CAS REGISTRY NUMBERS*
4517
4517
CLONED*
70794
70794
COFACTORS*
56910
56910
CRYSTALLIZATIONS*
19082
19082
EC CLASSES
4762
8424
3662 (77%)
ENGINEERING/MUTATIONS*
23234
119945
96711 (416%)
ENZYME SYNONYMS
53389
338439
285050 (534%)
EXPRESSION*
12622
12622
GENERAL INFORMATION*
78779
78779
GENERAL STABILITIES*
8804
8804
IC50 VALUES*
0
69886
69886
INHIBITORS*
112470
298358
185888 (165%)
KCAT/KM VALUES*
38626
38626
KI VALUES*
15736
46076
30340 (193%)
KM VALUES*
79431
176610
97179 (122%)
LIGAND 2D STRUCTURES
38488
159192
120704 (314%)
LIGANDS*
764282
2625795
1861513 (244%)
LOCALIZATION*
19011
65031
46020 (242%)
METALS AND IONS*
66371
66371
NATURAL SUBSTRATES OF ENZYMATIC REACTIONS*
51123
173436
122313 (239%)
ORGANIC SOLVENT STABILITIES*
3610
3610
ORGANISM
16018959
16018959
OXIDATION STABILITIES*
961
961
pH OPTIMA*
57293
57293
pH RANGES*
12998
12998
pH STABILITIES*
8814
8814
pI VALUES*
2060
7009
4949 (240%)
POSTTRANSLATIONAL MODIFICATIONS*
12119
12119
PURIFICATIONS*
65397
65397
REACTION TYPES*
13980
13980
REACTIONS
22912
22912
REFERENCE CITATIONS
108887
264349
155462 (143%)
REFERENCES
68366
3449964
3381598 (4946%)
RENATURED*
1393
1393
SEQUENCES
283138
32832265
32549127 (11496%)
SOURCE TISSUE*
44110
162209
118099 (268%)
SPECIFIC ACTIVITIES*
59868
59868
STORAGE STABILITIES*
11370
11370
SUBSTRATES AND PRODUCTS
511253
511253
SUBUNITS*
72360
72360
TEMPERATURE OPTIMA*
40549
40549
TEMPERATURE RANGES*
6601
6601
TEMPERATURE STABILITIES*
27079
27079
TURNOVER NUMBERS*
86919
86919
* = The numbers denote the enzyme-organism-(protein-)commentary-reference-specific occurrences. For kinetic values (Km, Ki, kcat) and ligand-specific fields (Inhibitors, Activating Compounds, Ligands) the corresponding enzyme ligand is also taken into account.
For example, when the identical pI (isoelectric point) was measured for different enzymes or the identical enzyme from different organisms the information is included for each EC number and organism-specific enzyme isoform, respectively.