Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.269: 2-(S)-hydroxypropyl-CoM dehydrogenase

This is an abbreviated version!
For detailed information about 2-(S)-hydroxypropyl-CoM dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.269

Reaction

(2S)-2-hydroxypropyl-CoM
+
NAD+
=
2-oxopropyl-CoM
 +
NADH
 +
H+

Synonyms

(S)-hydroxypropyl-coenzyme M dehydrogenase, (S)-hydroxypropylthioethanesulfonate dehydrogenase, 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase, HPCDH3, S-HPCDH, xecE, xecE1, xecE3

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.269 2-(S)-hydroxypropyl-CoM dehydrogenase

Engineering

Engineering on EC 1.1.1.269 - 2-(S)-hydroxypropyl-CoM dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K214A
substantially reduced catalytic efficiencies with the natural substrates in both the oxidative and reductive direction
R211A
substantially reduced catalytic efficiencies with the natural substrates in both the oxidative and reductive direction
S143A
residue acts as H-bond donor to substrate and in charge stabilization of the transition state, large increase in Km value
Y156A
mutation in general acid/base, large increase in Km value