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1.14.12.23: nitroarene dioxygenase

This is an abbreviated version!
For detailed information about nitroarene dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.23

Reaction

nitrobenzene
+
NADH
 +
O2
=
catechol
 +
nitrite
 +
NAD+

Synonyms

2-chloronitrobenzene dioxygenase, 2NTDO, cnbA, cnbAa, cnbAb, cnbAc, cnbAd, MntAa, MntAb, MntAc, MntAd, naphthalene dioxygenase, nbzAa, nbzAb, nbzAc, nbzAd

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.23 nitroarene dioxygenase

Crystallization

Crystallization on EC 1.14.12.23 - nitroarene dioxygenase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
oxygenase component, to 1.2 A resolution, hexagonal space group P63 with cell dimensions a = b = 121.6 A and c = 84.4 A
-
native enzyme and in complex with nitrobenzene and 3-nitrotoluene, to 1.2 A, 1.55 A and 1.5 A resolution, respectively. Enzyme shows a mushroom-shaped alpha3beta3 hexamer. The catalytic subunit contains a Rieske iron-sulfur center and an active-site mononuclear iron atom. The substrate pocket contains an asparagine residue that forms a hydrogen bond to the nitro-group of the substrate, and orients the substrate in relation to the active-site mononuclear iron atom