1.2.1.94: farnesal dehydrogenase
This is an abbreviated version!
For detailed information about farnesal dehydrogenase, go to the full flat file.
Word Map on EC 1.2.1.94
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1.2.1.94
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corneal
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polycyclic
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farnesoic
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2,3,7,8-tetrachlorodibenzo-p-dioxin
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blat
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aldh3b1
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clusterin
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allata
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granulosa-lutein
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as-odn
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opossum
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endometriosis
- 1.2.1.94
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corneal
-
polycyclic
-
farnesoic
- 2,3,7,8-tetrachlorodibenzo-p-dioxin
-
blat
- aldh3b1
-
clusterin
- allata
-
granulosa-lutein
-
as-odn
-
opossum
-
endometriosis
Reaction
Synonyms
AaALDH3, AaALDH3-1, AaALDH3-2, AaeL_AAEL012161, AaeL_AAEL012162, AaeL_AAEL012165, aldehyde dehydrogenase 3, ALDH3, farnesal dehydrogenase, farnesal dehydrogenase, NAD+, NAD+-dependent class 3 ALDH
ECTree
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General Information
General Information on EC 1.2.1.94 - farnesal dehydrogenase
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evolution
malfunction
metabolism
physiological function
the enzyme is a member of the NAD+-dependent class 3 ALDH family of the aldehyde dehydrogenase superfamily
evolution
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the enzyme is a member of the NAD+-dependent class 3 ALDH family of the aldehyde dehydrogenase superfamily
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reduction of AaALDH3 activity results in accumulation of farnesal and conversion back to farnesol that leaks outside the corpora allata
malfunction
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reduction of AaALDH3 activity results in accumulation of farnesal and conversion back to farnesol that leaks outside the corpora allata
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in the juvenile hormone JH III biosynthesis in insects, the alcohol farnesol, generated by the removal of diphosphate from farnesyl diphosphate, undergoes oxidation to the aldehyde (farnesal) and then to the acid (farnesoic acid). These steps are catalyzed by one or two NAD+-dependent dehydrogenase(s), JH III biosynthesis pathway, overview
metabolism
the enzyme is a biosynthetic enzyme of the juvenile hormone JH pathway
metabolism
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the enzyme is a biosynthetic enzyme of the juvenile hormone JH pathway
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results suggest that in the female Dengue mosquito Aedes aegypti, AaALDH3 enzyme plays a critical role in the regulation of juvenile hormone biosynthesis after blood feeding
physiological function
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the enzyme plays a key role in the regulation of juvenile hormone synthesis in blood-fed mosquito females
physiological function
the enzyme is a fatty aldehyde dehydrogenase (AaALDH3), NAD+-dependent class 3 ALDH, that oxidizes farnesal into farnesoic acid in the corpora allata of mosquitoes. In corporae allatae of blood-fed females, the low catalytic activity of AaALDH3 limits the flux of precursors and causes a remarkable increase in the pool of farnesal with a decrease in farnesoic acid and juvenile hormone synthesis. The accumulation of the potentially toxic farnesal stimulates the activity of a reductase that converts farnesal back into farnesol, resulting in farnesol leaking out of the corpora allata. Enzyme AaALDH3 plays a key role in the regulation of juvenile hormone synthesis in blood-fed females and mosquitoes seem to have developed a trade-off system to balance the key role of farnesal as a juvenile hormone precursor with its potential toxicity
physiological function
-
results suggest that in the female Dengue mosquito Aedes aegypti, AaALDH3 enzyme plays a critical role in the regulation of juvenile hormone biosynthesis after blood feeding
-
physiological function
-
the enzyme plays a key role in the regulation of juvenile hormone synthesis in blood-fed mosquito females
-
physiological function
-
the enzyme is a fatty aldehyde dehydrogenase (AaALDH3), NAD+-dependent class 3 ALDH, that oxidizes farnesal into farnesoic acid in the corpora allata of mosquitoes. In corporae allatae of blood-fed females, the low catalytic activity of AaALDH3 limits the flux of precursors and causes a remarkable increase in the pool of farnesal with a decrease in farnesoic acid and juvenile hormone synthesis. The accumulation of the potentially toxic farnesal stimulates the activity of a reductase that converts farnesal back into farnesol, resulting in farnesol leaking out of the corpora allata. Enzyme AaALDH3 plays a key role in the regulation of juvenile hormone synthesis in blood-fed females and mosquitoes seem to have developed a trade-off system to balance the key role of farnesal as a juvenile hormone precursor with its potential toxicity
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