1.21.4.1: D-proline reductase
This is an abbreviated version!
For detailed information about D-proline reductase, go to the full flat file.
Word Map on EC 1.21.4.1
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1.21.4.1
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stickland
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clostridial
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pyruvoyl
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toxin
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proproteins
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racemase
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difficile
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reductases
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threonine
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selenocysteine
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nabh4
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selenoenzyme
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selenium
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nadh-dependent
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nosocomial
- 1.21.4.1
-
stickland
-
clostridial
-
pyruvoyl
- toxin
- proproteins
- racemase
- difficile
- reductases
- threonine
- selenocysteine
- nabh4
-
selenoenzyme
- selenium
-
nadh-dependent
-
nosocomial
Reaction
Synonyms
5-aminopentanoate:lipoate oxidoreductase (cyclizing), D-proline reductase, D-proline reductase (dithiol), EC 1.4.1.6, EC 1.4.4.1, lipoate-linked proline reductase, PrdB
ECTree
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Systematic Name
Systematic Name on EC 1.21.4.1 - D-proline reductase
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5-aminopentanoate:[PrdC protein] oxidoreductase (cyclizing)
A pyruvoyl- and L-selenocysteine-containing enzyme found in a number of Clostridial species. The pyruvoyl group, located on the PrdA subunit, binds the substrate, while the selenocysteine residue, located on the PrdB subunit, attacks the alpha-C-atom of D-proline, leading to a reductive cleavage of the C-N-bond of the pyrrolidine ring and formation of a selenoether. The selenoether is cleaved by a cysteine residue of PrdB, resulting in a mixed selenide-sulfide bridge, which is restored to its reduced state by another selenocysteine protein, PrdC. 5-aminopentanoate is released from PrdA by hydrolysis, regenerating the pyruvoyl moiety. The resulting mixed selenide-sulfide bridge in PrdC is reduced by NADH.