1.5.1.44: festuclavine dehydrogenase
This is an abbreviated version!
For detailed information about festuclavine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.1.44
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1.5.1.44
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ergot
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chanoclavine-i
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fumigatus
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yellow
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shunt
- 1.5.1.44
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ergot
- chanoclavine-i
- fumigatus
- yellow
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shunt
Reaction
Synonyms
EasA, EasG, ergot alkaloid biosynthetic protein G, festuclavine synthase, festuclavine synthase I, festuclavine synthase II, FgaFS, ifgF1, ifgF2, isofumigaclavine biosynthesis cluster A protein F1, isofumigaclavine biosynthesis cluster A protein F2
ECTree
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General Information
General Information on EC 1.5.1.44 - festuclavine dehydrogenase
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evolution
malfunction
metabolism
physiological function
organization of the clavine gene clusters in different species, e.g. clusters A and B of isofumigaclavine in Penicillium roqueforti, overview
evolution
organization of the clavine gene clusters in different species, e.g. fumigaclavine A gene cluster of Penicillium commune, overview
evolution
organization of the clavine gene clusters in different species, e.g. fumigaclavine C gene cluster in Neosartorya fumigata, overview
evolution
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organization of the clavine gene clusters in different species, overview
evolution
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organization of the clavine gene clusters in different species, e.g. clusters A and B of isofumigaclavine in Penicillium roqueforti, overview
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evolution
Aspergillus fumigatus CBS 101355
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organization of the clavine gene clusters in different species, e.g. fumigaclavine C gene cluster in Neosartorya fumigata, overview
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evolution
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organization of the clavine gene clusters in different species, e.g. fumigaclavine C gene cluster in Neosartorya fumigata, overview
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evolution
Aspergillus fumigatus FGSC A1100
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organization of the clavine gene clusters in different species, e.g. fumigaclavine C gene cluster in Neosartorya fumigata, overview
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evolution
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organization of the clavine gene clusters in different species, e.g. fumigaclavine C gene cluster in Neosartorya fumigata, overview
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accumulation of prenylated intermediates and lack of fumigaclavine A formation has been reported in mutants of Neosartorya fumigata disrupted in the festuclavine hydroxylase
malfunction
Aspergillus fumigatus CBS 101355
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accumulation of prenylated intermediates and lack of fumigaclavine A formation has been reported in mutants of Neosartorya fumigata disrupted in the festuclavine hydroxylase
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malfunction
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accumulation of prenylated intermediates and lack of fumigaclavine A formation has been reported in mutants of Neosartorya fumigata disrupted in the festuclavine hydroxylase
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malfunction
Aspergillus fumigatus FGSC A1100
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accumulation of prenylated intermediates and lack of fumigaclavine A formation has been reported in mutants of Neosartorya fumigata disrupted in the festuclavine hydroxylase
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malfunction
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accumulation of prenylated intermediates and lack of fumigaclavine A formation has been reported in mutants of Neosartorya fumigata disrupted in the festuclavine hydroxylase
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clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
metabolism
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Finally, in Neosartorya fumigata, there is a step that involves the prenylation of fumigaclavine A to form fumigaclavine C. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
metabolism
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A
metabolism
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A
metabolism
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A
metabolism
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A
metabolism
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A
metabolism
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
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metabolism
Aspergillus fumigatus CBS 101355
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Finally, in Neosartorya fumigata, there is a step that involves the prenylation of fumigaclavine A to form fumigaclavine C. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
-
metabolism
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Finally, in Neosartorya fumigata, there is a step that involves the prenylation of fumigaclavine A to form fumigaclavine C. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
-
metabolism
Aspergillus fumigatus FGSC A1100
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Finally, in Neosartorya fumigata, there is a step that involves the prenylation of fumigaclavine A to form fumigaclavine C. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
-
metabolism
-
clavine and lysergic acid-containing alkaloids derive from the condensation of tryptophan and dimethylallylpyrophosphate (DMA-PP), catalyzed by the first enzyme of the pathway, named dimethylallyltryptophan synthase (DMATS). This results in the formation of tricyclic intermediates, the most relevant being chanoclavine I and chanoclavine I aldehyde, which the branch point intermediate for the formation of different types of alkaloids. Chanoclavine I aldehyde, is later cyclized to form the tetracyclic ergoline nucleus. The ergoline structure constitutes the nucleus of festuclavine, agroclavine, elymoclavine, pyroclavine and their derivatives. In agroclavine and elymoclavine, there is a double bond between carbons C-8 and C-9, whereas in festuclavine this double bond is not present. Pyroclavine, an C-8 stereoisomer (carbons 8R/9S) of festuclavine (carbon 8S/9S), is also present in cultures of some of the clavine alkaloids producers. The late steps of the biosynthesis of fumigaclavine alkaloids involve the oxidation of festuclavine to 9-hydroxyfestuclavine (named fumigaclavine B) and later the acetylation of fumigaclavine B to fumigaclavine A. Finally, in Neosartorya fumigata, there is a step that involves the prenylation of fumigaclavine A to form fumigaclavine C. Comparison of the synthetic pathway of isofumigaclavine A in Penicillium roqueforti and fumigaclavine C in Neosartorya fumigata
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gene ifgF1 encodes a festuclavine synthase that is involved in the conversion of chanoclavine I aldehyde into festuclavine
physiological function
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gene ifgF1 encodes a festuclavine synthase that is involved in the conversion of chanoclavine I aldehyde into festuclavine
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