1.5.3.6: (R)-6-hydroxynicotine oxidase
This is an abbreviated version!
For detailed information about (R)-6-hydroxynicotine oxidase, go to the full flat file.
Word Map on EC 1.5.3.6
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1.5.3.6
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fad
-
arthrobacter
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oxidans
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flavinylation
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holoenzyme
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flavin
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flavoproteins
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6-hydroxy-l-nicotine
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flavoenzymes
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apoenzyme
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nicotinovorans
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nicotine-degrading
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l-nicotine
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dimethylglycine
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glycerol-3-p
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cotranslational
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fad-binding
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l-enantiomer
- 1.5.3.6
- fad
- arthrobacter
- oxidans
-
flavinylation
-
holoenzyme
- flavin
- flavoproteins
- 6-hydroxy-l-nicotine
-
flavoenzymes
-
apoenzyme
- nicotinovorans
-
nicotine-degrading
- l-nicotine
- dimethylglycine
-
glycerol-3-p
-
cotranslational
-
fad-binding
-
l-enantiomer
Reaction
Synonyms
6-HDNO, 6-hydroxy-D-nicotine oxidase, D-6-hydroxynicotine oxidase
ECTree
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General Information
General Information on EC 1.5.3.6 - (R)-6-hydroxynicotine oxidase
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metabolism
Q8GAG1
a network of hydrogen-bonded residues in the active site is involved in binding the neutral form of the amine substrate, followed by the transfer of a hydride from the amine to the flavin. There is no solvent isotope effect on the kcat/Kamine value with either (R)-6-hydroxynicotine or the slower substrate (R)-6-hydroxynornicotine. Only the neutral form of the substrate and the correctly protonated form of the enzyme bind. The active-site residues Lys348, Glu350, and Glu352 are all properly positioned for substrate binding