1.6.3.1: NAD(P)H oxidase (H2O2-forming)

This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O2-forming), go to the full flat file.

Reaction

Synonyms

100787949, 100812342, 100820185, Atrbohc, AtrbohD NADPH oxidase, AtrbohF NADPH oxidase, BLI-3, cytochrome b-245 heavy chain, dual oxidase, Duox, Duox-DuoxA NADPH oxidase, Duox1, Duox2, Glyma.03G236300, Glyma.19G233900, Glyma.20G236200, GLYMA_10G152200, gp91phox, gp91phox/Nox2, KOD1, large NOX, LNOX, NAD(P)H oxidase, NAD(P)H oxidase 4, NADH oxidase, NADPH oxidase, NADPH oxidase 1, NADPH oxidase 2, NADPH oxidase 4, NADPH oxidase 5, NADPH oxidase type 4, NADPH-oxidase, NADPHox, NAPDH oxidase, NM_001184780, NOX, NOX1, Nox2, NOX3, Nox4, NOX4-art, NOX5, p138 thyroid-oxidase, p138tox, p47phox, p67phox, phagocyte NADPH oxidase, phox, RBOH, RBOHB, RbohF, RDH2, RdxA, renal oxidase, renox, Respiratory Burst Oxidase Homolog, respiratory burst oxidase homologue, rth5, SsNOX38, superoxide-generating NADPH oxidase, ThOX, ThOX2, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, TK0304, TK0828, TK1186, TK1299, TK1481

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.3 With oxygen as acceptor

                1.6.3.1 NAD(P)H oxidase (H2O2-forming)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
104	Activating Compound
3053	AA Sequence
88	Application
1	CAS Registry Number
32	Cloned(Commentary)
105	Cofactor
3	Crystallization (Commentary)
4174	Disease/ Diagnostics
47	Expression
72	General Information
6	General Stability
58	IC50 Value
331	Inhibitors
1	kcat/KM [mM/s]
71	Ki Value [mM]
10	KM Value [mM]
100	Localization
50	Metals/Ions
24	Molecular Weight [Da]
110	Natural Substrates/ Products (Substrates)
627	Organism
4	PDB ID
7	pH Optimum
1	pH Range
27	Posttranslational Modification
63	Protein Variants
11	Purification (Commentary)
5	Reaction
3	Reaction Type
299	Reference
491	Source Tissue
8	Specific Activity [micromol/min/mg]
1	Storage Stability
183	Substrates and Products (Substrate)
31	Subunits
237	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

Crystallization

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Crystallization on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Crystallization (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

sitting drop vapor diffusion method, using 160 mM Ca-acetate, 80 mM Na-Cacodylate pH 6.5, 12.16% (w/v) PEG 8000, 20% (v/v) glycerol

Cylindrospermum stagnale

K9WT99

743694

enzyme crystallizes as dimer, with each monomer consisting of a FAD-binding domain, a NAD(P)H -binding domain and a dimerization domain. Redox-active C42 is in sulfenic acid state Cys-SOH and shows two conformations, either hydrogen bonded to H10 or hydrogen bonded to FAD O2’ atom. The NAD(P)H-binding domains each contain ATP as ligand, being not inhibitory to the enzyme

Fructilactobacillus sanfranciscensis

-

672212

homology modeling of structure using the crystal structure of Lactobacillus sanfranciscensis. In contrast to Lactobacillus sanfranciscensis, the Lactococcus lactis enzyme does not bind ADP, being consistent with its specificity for NADH

Lactococcus lactis

-

672212