2.1.1.178: 16S rRNA (cytosine1407-C5)-methyltransferase
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For detailed information about 16S rRNA (cytosine1407-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
16S rRNA methyltransferase, housekeeping methyltransferase RsmF, RNA m5C methyltransferase YebU, RsmF, RsmF housekeeping methyltransferase, YebU
ECTree
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Inhibitors
Inhibitors on EC 2.1.1.178 - 16S rRNA (cytosine1407-C5)-methyltransferase
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introduction of a recombinant version of the Sgm methyltransferase gene from Micromonospora zionensis into an Escherichia coli strain that has a full complement of housekeeping methyltransferases. Analyses of the 16S rRNA shows that the m5C1407-specific housekeeping methyltransferase RsmF (YebU) is outcompeted by Sgm as the resistance methyltransferase gains access to its own m7G1405 target on the 30S ribosomal subunit. A single amino acid change in Sgm, which lowers the level of conferred resistance, reduces the ability of Sgm to interfere with RsmF methylation on the 30S subunit
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additional information
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RmtC, EC 2.1.1.179, in the presence of aminoglycosides impedes methylation at the N5 position of nucleotide C1407 when the N7 position of G1405 is methylated, MALDI mass spectrometry product analysis, mechanism, overview
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