2.1.1.201: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
This is an abbreviated version!
For detailed information about 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, go to the full flat file.
Word Map on EC 2.1.1.201
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2.1.1.201
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ubiquinone
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phytoremediation
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selenium
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c-methylation
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broccoli
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medicine
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environmental protection
- 2.1.1.201
- ubiquinone
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phytoremediation
- selenium
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c-methylation
- broccoli
- medicine
- environmental protection
Reaction
Synonyms
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, BoCOQ5-2, BoCOQ5-2 methyltransferase, C-methyltransferase Coq5, COQ5, Coq5 C-methyltransferase, COQ5 methyltransferase, UbiE, ubiquinone biosynthesis O-methyltransferase
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General Information
General Information on EC 2.1.1.201 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
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malfunction
metabolism
physiological function
additional information
deletion of the chromosomal COQ5 gene results in a respiration deficiency and reduced levels of respiratory protein components
malfunction
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strains of Escherichia coli with mutations in the ubiE gene are not able to catalyze the carbon methylation reaction in the biosynthesis of ubiquinone (coenzyme Q) and menaquinone (vitamin K2), essential isoprenoid quinone components of the respiratory electron transport chain
malfunction
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ubiE mutant accumulate 2-methoxy-6-octaprenyl-1,4-benzoquinol
malfunction
in humans, mutations in several COQ genes cause primary Q deficiency, and a decrease in coenzyme Q biosynthesis is associated with mitochondrial, cardiovascular, kidney and neurodegenerative diseases
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the broccoli BoCOQ5-2 methyltransferase gene is involved in the ubiquinone biosynthetic pathway
metabolism
Coq5 is an S-adenosyl methionine-dependent methyltransferase (SAM-MTase) that catalyzes the only C-methylation step in the coenzyme Q (CoQ) biosynthesis pathway, in which 2-methoxy-6-polyprenyl-1,4-benzoquinone (DDMQH2) is converted to 2-methoxy-5-methyl-6-polyprenyl-1,4-benzoquinone
Coq5p catalyzes a step in ubiquinone biosynthesis and is essential for the stability and activity of other Coq polypeptides involved in Q biosynthesis (Coq3 and Coq4)
physiological function
expression of BoCOQ5-2 in bacteria or Arabidopsis increases seleniume volatilization and tolerance.
physiological function
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BoCOQ5-2 methyltransferase is a facilitator of selenium volatilization
physiological function
enzyme Coq5 catalyzes the only C-methylation involved in the biosynthesis of coenzymeQ(Q or ubiquinone) in humans
physiological function
chemical uncoupler carbonyl cyanide-p-trifluoromethoxyphenylhydrazone suppresses the COQ5 in mitochondrion and in cybrids with MERRF mutation, associated with decreased mitochondrial membrane potential and mitochondrial ATP production. Total CoQ10 levels are decreased under both conditions, but the ubiquinol-10:ubiquinone-10 ratio is increased in mutant cybrids. The expression of COQ5 is increased but COQ5 protein maturation is suppressed in the mutant cybrids
physiological function
the lack of COQ9 in Coq9Q95X middle-age mutant mice triggers the reduction of COQ7, COQ6 and COQ5, which results in an increase in life expectancy. The hepatic CoQ levels are not decreased and neither mitochondrial dysfunction or increased oxidative stress are observed in liver
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expression of BoCOQ5-2 stimulates Se volatilization in bacteria and plants
additional information
Coq5 displays a typical class I SAM-MTase structure with two minor variations beyond the core domain, both of which are considered to participate in dimerization and/or substrate recognition. Slight conformational changes at the active-site pocket are observed upon binding of SAM. Remodelling of the substrate-binding site, structure-based computational simulation, overview
additional information
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Coq5 displays a typical class I SAM-MTase structure with two minor variations beyond the core domain, both of which are considered to participate in dimerization and/or substrate recognition. Slight conformational changes at the active-site pocket are observed upon binding of SAM. Remodelling of the substrate-binding site, structure-based computational simulation, overview