2.1.1.219: tRNA (adenine57-N1/adenine58-N1)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (adenine57-N1/adenine58-N1)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.219
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2.1.1.219
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pyrococcus
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avermitilis
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t-loop
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putidaredoxin
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s-adenosyl-l-homocysteine
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ferredoxins
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region-specific
- 2.1.1.219
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pyrococcus
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avermitilis
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t-loop
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putidaredoxin
- s-adenosyl-l-homocysteine
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ferredoxins
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region-specific
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
bi-specific tRNA adenine-N1, A57-A58-methyltransferase, bi-specific tRNA adenine-N1, A57-A58-MTase, EC 2.1.1.36, PAB0283 protein, PabTrmI, PYRAB04300, TrmI, tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase, tRNA (m1A) methyltransferase, tRNA m1A57/58 methyltransferase, tRNA(m1A57/58)-methyltransferase
ECTree
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General Information
General Information on EC 2.1.1.219 - tRNA (adenine57-N1/adenine58-N1)-methyltransferase
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additional information
PabTrmI methylates efficiently the first adenine of the A57A58A59 sequence. m1A58 formation triggers RNA release. A model of the protein-tRNA complex shows both target adenines in proximity of S-adenosyl-L-methionine and emphasizes no major tRNA conformational change except base flipping during the reaction. The solvent accessibility of the S-adenosyl-L-methionine pocket is not affected by the tRNA, thereby enabling S-adenosyl-L-homocysteine to be replaced by S-adenosyl-L-methionine without prior release of monomethylated tRNA. Dynamics of RNA binding by PabTrmI in the presence and absence of S-adenosyl-L-methionine, structural model of PabTrmI in complex with tRNA, overview
additional information
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PabTrmI methylates efficiently the first adenine of the A57A58A59 sequence. m1A58 formation triggers RNA release. A model of the protein-tRNA complex shows both target adenines in proximity of S-adenosyl-L-methionine and emphasizes no major tRNA conformational change except base flipping during the reaction. The solvent accessibility of the S-adenosyl-L-methionine pocket is not affected by the tRNA, thereby enabling S-adenosyl-L-homocysteine to be replaced by S-adenosyl-L-methionine without prior release of monomethylated tRNA. Dynamics of RNA binding by PabTrmI in the presence and absence of S-adenosyl-L-methionine, structural model of PabTrmI in complex with tRNA, overview
additional information
Pyrococcus abyssi GE5 / CNCM I-1302 / DSM 25543
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PabTrmI methylates efficiently the first adenine of the A57A58A59 sequence. m1A58 formation triggers RNA release. A model of the protein-tRNA complex shows both target adenines in proximity of S-adenosyl-L-methionine and emphasizes no major tRNA conformational change except base flipping during the reaction. The solvent accessibility of the S-adenosyl-L-methionine pocket is not affected by the tRNA, thereby enabling S-adenosyl-L-homocysteine to be replaced by S-adenosyl-L-methionine without prior release of monomethylated tRNA. Dynamics of RNA binding by PabTrmI in the presence and absence of S-adenosyl-L-methionine, structural model of PabTrmI in complex with tRNA, overview
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