2.1.1.231: flavonoid 4'-O-methyltransferase

This is an abbreviated version!
For detailed information about flavonoid 4'-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

4'-O-methyltransferase, 4'OMT, B-ring 4'OMT, F 4'-OMT, flavonoid 4'-O-methyltransferase, GerMIII, O-methyltransferase, OMT, regiospecific flavonoid 4'OMT, SOMT-2, SOMT2, soybean O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.231 flavonoid 4'-O-methyltransferase

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Results	in table
1	Activating Compound
3	AA Sequence
1	Application
5	Cloned(Commentary)
3	Cofactor
4	General Information
11	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
6	Organism
3	Pathway
2	pH Optimum
1	pI Value
1	Protein Variants
3	Purification (Commentary)
2	Reaction
6	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
29	Substrates and Products (Substrate)
4	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

General Information

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General Information on EC 2.1.1.231 - flavonoid 4'-O-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Streptomyces sp. KCTC 0041BP

Q331Q6

GerMIII is present on the biosynthetic gene cluster of dihydrochalcomycin, a macrolide antibiotic that is produced by the Streptomyces sp. KCTC 0041BP. Based on its dependency on the metallic cofactor requirement for its reaction, the enzyme resembles the Class-II plant OMTs

756617

metabolism

Glycine max

C6TAY1

the enzyme catalyzes the last step in the biosynthesis of the bioactive flavonoid ponciretin, biosynthetic pathways starting with glucose, overview

735537

physiological function

Streptomyces sp. KCTC 0041BP

Q331Q6

the methylation at the 4'-hydroxyl group of the B-ring of flavonoids confers a structural constraint for autooxidation, importance of the regiospecific 4'-OMT

756617

additional information

Streptomyces sp. KCTC 0041BP

Q331Q6

a double bond between the C2 and the C3 and a single-ring-appended conjugate-hydroxyl group are crucial for the favorable enzymatic conversions of the GerMIII catalysis, modeling and molecular docking

756617