2.1.1.70: 8-hydroxyfuranocoumarin 8-O-methyltransferase
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For detailed information about 8-hydroxyfuranocoumarin 8-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
EC 2.1.1.93, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, methyltransferase, xanthotoxol, XMT
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.70 - 8-hydroxyfuranocoumarin 8-O-methyltransferase
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S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase
Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).