2.1.1.B74: apigenin 7-O-methyltransferase
This is an abbreviated version!
For detailed information about apigenin 7-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
F1-OMT, F7OMT, flavone 7-O-methyltransferase, flavonoid 7-O-methyltransferase, flavonoid 7-OMT, POMT-7, POMT7
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.B74 - apigenin 7-O-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-7-methoxyflavanone
i.e. eriodictyol, about 10% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)
-
-
?
S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone
S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone
i.e. kaempferol, about 15% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)
-
-
?
S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxyflavone
S-adenosyl-L-homocysteine + 7-methoxy-5,3',4'-tetrahydroxyflavone
i.e. luteolin, about 15% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)
-
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavanone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavanone
i.e. naringenin, about 30% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)
i.e. sakuranetin
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + 7-O-methylapigenin
-
-
i.e. genkwanin
-
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + genkwanin
-
-
-
?
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
i.e. apigenin. The product genkwanin exhibits a stronger inhibitory effect on the germination of spores from pathogenic fungi as compared to the effect of apigenin
i.e. genkwanin
-
?
S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone
i.e. apigenin, sequential bi-bi mechanism
i.e. genkwanin
-
?