2.3.1.211: bisdemethoxycurcumin synthase
This is an abbreviated version!
For detailed information about bisdemethoxycurcumin synthase, go to the full flat file.
Word Map on EC 2.3.1.211
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2.3.1.211
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curcuminoids
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oryza
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polyketide
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sativa
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synthesis
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turmeric
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starter
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curcuma
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longa
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thioester
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diarylheptanoids
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gingerol
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4-coumaroyl-coas
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phenylpropanoids
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rhizome
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hepatoprotective
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erythrorhizon
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cinnamic
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diketide
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one-pot
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shoot
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ammonia-lyase
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4-coumarate
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plant-specific
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lithospermum
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4-coumarate:coa
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analysis
- 2.3.1.211
-
curcuminoids
- oryza
- polyketide
- sativa
- synthesis
- turmeric
-
starter
-
curcuma
- longa
- thioester
-
diarylheptanoids
- gingerol
- 4-coumaroyl-coas
-
phenylpropanoids
- rhizome
-
hepatoprotective
- erythrorhizon
-
cinnamic
-
diketide
-
one-pot
- shoot
-
ammonia-lyase
- 4-coumarate
-
plant-specific
-
lithospermum
-
4-coumarate:coa
- analysis
Reaction
2 4-coumaroyl-CoA + + = 3 CoA + + 2 CO2
Synonyms
ClPKS10, curcumin synthase, curcuminoid synthase, CUS, Os07g0271500, OsCUS
ECTree
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Reaction
Reaction on EC 2.3.1.211 - bisdemethoxycurcumin synthase
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2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2
curcuminoid synthase catalyzes the formation of diketide-CoA by condensing 4-coumaroyl-CoA and malonyl-CoA. The resulting diketide-CoA is hydrolyzed and converted to a beta-keto acid. Finally, curcuminoid synthase catalyzes a decarboxylative condensation of the beta-keto acid with another molecule of 4-coumaroyl-CoA, to synthesize curcuminoid
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2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2
no head-to-tail synthesis, the reaction begins with the thioesterification of the thiol moiety of Cys-174 by a starter molecule, 4-coumaroyl-CoA. Decarboxylative condensation of the first extender substrate, malonyl-CoA, onto the thioester of 4-coumarate results in the formation of a diketide-CoA intermediate. Subsequent hydrolysis of the intermediate yields a beta-keto acid, which in turn acts as the second extender substrate. The beta-keto acid is then joined to the Cys-174-bound 4-coumarate by decarboxylative condensation to form bisdemethoxycurcumin
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2
the reaction proceeds in three steps via formation of 4-coumaroyldiketide-CoA and 4-coumaroyl beta-keto acid, overview
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