2.3.1.45: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
This is an abbreviated version!
For detailed information about N-acetylneuraminate 7-O(or 9-O)-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.45
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2.3.1.45
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o-acetylation
-
ganglioside
-
analysis
-
o-acetylesterase
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accoa
-
cmp-neu5ac
-
gd3
-
sialyltransferase
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sialate-o-acetylesterase
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submandibular
-
neu5ac
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glycolipids
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sialylation
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neu5,9ac2
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all-cell
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cmp-n-acetylneuraminic
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glycosphingolipids
-
sialidase
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ppp1r9a
-
sialoglycoproteins
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7-o-acetylated
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acid-specific
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de-o-acetylating
-
medicine
- 2.3.1.45
-
o-acetylation
- ganglioside
- analysis
-
o-acetylesterase
- accoa
- cmp-neu5ac
- gd3
-
sialyltransferase
- sialate-o-acetylesterase
-
submandibular
- neu5ac
- glycolipids
-
sialylation
-
neu5,9ac2
-
all-cell
-
cmp-n-acetylneuraminic
- glycosphingolipids
- sialidase
-
ppp1r9a
-
sialoglycoproteins
-
7-o-acetylated
-
acid-specific
-
de-o-acetylating
- medicine
Reaction
Synonyms
7(9)-OAT, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(or7)-O-acetyltransferase, acetyltransferase, N-acetylneuraminate 9(7)-O-, CAS1 domain-containing protein 1, CASD1, glycoprotein 7(9)-O-acetyltransferase, group B streptococcal sialic acid O-acetyltransferase, More, N-acetylneuraminate 7(8)-O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, N-acetylneuraminate 9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, NeuD, NeuD O-acetyltransferase, OAT, Sia O-acetyltransferase, sialate O-acetyltransferase, sialate-7(9)-O-acetyltransferase, sialate-O-acetyl transferase, sialate-O-acetyltransferase, sialyl-O-acetyltransferase, SOAT
ECTree
2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.1.45 - N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + CMP-5-N-acetylneuraminate
CoA + CMP-5-N-acetyl-9-O-acetylneuraminate
-
-
-
?
acetyl-CoA + CMP-5-N-acetylneuraminic acid
CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + CMP-5-N-acetylneuraminic acid
CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. terminal alpha2,8-linked sialic acid occurs on the glycerol side chain of GD3, where it reverses FAS-mediated apoptotic effects, suggesting a role of GD3 O-acetylation in regulating induced apoptosis, GD2 O-acetylation is oberseved in breast cancer
-
-
?
acetyl-CoA + CMP-5-N-acetylneuraminic acid
CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. via 9-O-acetylation on colonic mucins, overview
-
-
?
acetyl-CoA + CMP-N-acetylneuraminate
CoA + N-acetyl-9-O-acetylneuraminate + CMP
-
-
-
?
acetyl-CoA + CMP-N-acetylneuraminic acid
CoA + CMP-N-acetyl-9-O-acetyl-neuraminate
-
the CMP-N-acetyl-neuraminic acid and acetyl-CoA transporters are critical components for the O-acetylation of CMPNeu5Ac in Golgi lumen, with specific inhibition of either transporter leading to a reduction in the formation of CMP-5-N-acetyl-9-O-acetyl-neuraminic acid, O-acetylation in human colon Golgi vesicles is regulated by the concentration of CMP-Neu5Ac and AcCoA in the lumen, both being under the control of specific transport proteins, overview
-
-
?
acetyl-CoA + N-acetyl-9-O-acetylneuraminate
N-acetyl-7,9-O-diacetylneuraminate
-
-
-
ir
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. in regulation of cancer development via GD3-O-acetylation, overview
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + 5-N-acetylneuraminic acid
CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-7-O-acetylneuraminate
-
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-7-O-acetylneuraminate
-
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-7-O-acetylneuraminate
-
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-7-O-acetylneuraminate
-
-
-
-
?
acetyl-CoA + N-acetylneuraminate
CoA + N-acetyl-9-O-acetylneuraminate
-
-
-
ir
acetyl-CoA + N-acetylneuraminic acid
CoA + N-acetyl-9-O-acetyl-neuraminate
-
no 7-O-acetylation
-
?
acetyl-CoA + N-acetylneuraminic acid
CoA + N-acetyl-9-O-acetyl-neuraminate
-
-
-
?
acetyl-CoA + N-acetylneuraminic acid
CoA + N-acetyl-9-O-acetyl-neuraminate
-
-
-
-
?
acetyl-CoA + N-acetylneuraminic acid
CoA + N-acetyl-O-acetyl-neuraminate
-
-
the 9-O-acetyl neuraminic acid is the main product, but small amounts of 7-O-acetylated neuraminic acid are also detected, oligo-O-acetylated species are 5-N-acetyl-8,9-di-O-acetylneuraminic acid and 5-N-acetyl-7,8,9-tri-O-acetylneuraminic acid, acids, but neither 5-N-acetyl-7,8-di-O-acetylneuraminic acid nor 5-N-acetyl-7,9-di-O-acetylneuraminic acid are formed, in microsomes, a migrase is involved catalysing the rapid migration of O-acetyl groups along the glycerol side chain, subsequently followed by the transfer of another acetyl group, facilitating the formation of 5-N-acetyl-7,8,9-tri-O-acetylneuraminic acid, overview
-
?
acetyl-CoA + N-acetylneuraminic acid
CoA + N-acetyl-O-acetyl-neuraminate
-
the level of free cytosolic Neu5,9Ac2 in human colon is regulated by the relative activity of the cytosolic sialate-O-acetylesterase
mono- and oligoacetylated products, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
sialic acid distribution, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
sialic acid distribution, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
sialic acid distribution, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
sialic acid distribution, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
-
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
sialic acid distribution, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
sialic acid distribution, overview
-
?
acetyl-CoA + sialic acid
CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
pathway, overview
-
?
additional information
?
-
-
Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview
-
-
?
additional information
?
-
-
the O-acetylation of sialic acids in various positions is a frequent modification of these residues in glycoproteins and glycolipids, sialic acid O-acetylation is involved in the regulation of many cell biological and pathophysiological events
-
-
?
additional information
?
-
the enzyme is involved in the lipo-oligosaccharide biosynthesis, and in production of sialylated outer core structures that mimic host gangliosides, implicated in triggering the onset of Guillain-Barré syndrome
-
-
?
additional information
?
-
-
Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, one acceptor substrate is GD3, overview
-
-
?
additional information
?
-
-
Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview
-
-
?
additional information
?
-
Escherichia coli K1, a leading cause of neonatal sepsis and meningitis, expresses a surface CPS containing Neu5Ac, further modified this Sia by O-acetylation
-
-
?
additional information
?
-
-
5-N-acetyl-9-O-acetyl-neuraminic acid can be transferred from neo-synthesised CMP-Neu5,9Ac2 to various endogenous glycoproteins in the same Golgi vesicles
-
-
?
additional information
?
-
-
Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, enzyme role in regulation, the enzyme colaborates with the sialate O-acetylesterase, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview
-
-
?
additional information
?
-
enzyme CASD1 mediates 9-O-acetylation of cellular sialoglycans and sialoglycoconjugates
-
-
?
additional information
?
-
-
enzyme CASD1 mediates 9-O-acetylation of cellular sialoglycans and sialoglycoconjugates
-
-
?
additional information
?
-
-
Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview
-
-
?
additional information
?
-
-
Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview
-
-
?
additional information
?
-
-
NeuD O-acetyltransferase plays roles in both sialic acid biosynthesis and regulation of the O-acetyl modification
-
-
?
