2.3.2.B11: ubiquitin transferase RING E3 (calmodulin-selective)
This is an abbreviated version!
For detailed information about ubiquitin transferase RING E3 (calmodulin-selective), go to the full flat file.
Word Map on EC 2.3.2.B11
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2.3.2.B11
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ligases
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polyubiquitination
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finger
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ubiquitin-proteasome
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mdm2
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parkin
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adaptor
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ubiquitin-like
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ubiquitin-dependent
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sumoylation
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sumo
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monoubiquitination
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skp2
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ubiquitin-mediated
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proteasome-dependent
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itch
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cullin-ring
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k63-linked
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deubiquitinase
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nedd4-2
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ring-type
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neddylation
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sumo-targeted
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angelman
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kaufman
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scfskp2
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pten-induced
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autoubiquitination
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bard1
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smurf2
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hsc70-interacting
- 2.3.2.B11
- ligases
-
polyubiquitination
- finger
-
ubiquitin-proteasome
- mdm2
- parkin
- adaptor
-
ubiquitin-like
-
ubiquitin-dependent
-
sumoylation
- sumo
-
monoubiquitination
- skp2
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ubiquitin-mediated
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proteasome-dependent
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itch
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cullin-ring
-
k63-linked
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deubiquitinase
- nedd4-2
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ring-type
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neddylation
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sumo-targeted
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angelman
-
kaufman
-
scfskp2
-
pten-induced
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autoubiquitination
- bard1
- smurf2
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hsc70-interacting
Reaction
Synonyms
Asr1p, E3-CaM, More, synthetase, ubiquitin-calmodulin, UBE3B, ubiquitin E3 ligase, ubiquityl-calmodulin synthase, ubiquityl-calmodulin synthetase, uCaM-synthetase
ECTree
2.3.2.B11 ubiquitin transferase RING E3 (calmodulin-selective)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.2.B11 - ubiquitin transferase RING E3 (calmodulin-selective)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine
[RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
n ATP + calmodulin + n ubiquitin
?
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specific function of the enzyme in the Ca2+-dependent breakdown of calmodulin in vertebrate (eukaryotic) cells
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?
n ATP + calmodulin + n ubiquitin
?
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Ca2+-dependent ubiquitination only of free calmodulin may provide an efficient scavenging mechanism (with subsequent breakdown) for all free calmodulin in excess of that amount which can be found by the calmodulin-binding proteins in the cell
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?
n ATP + calmodulin + n ubiquitin
?
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the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold
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?
n ATP + calmodulin + n ubiquitin
?
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it is very probably that the ubiquitination of calmodulin belongs to the normal regulatory repertoire of the eukaryotic cell
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?
n ATP + calmodulin + n ubiquitin
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monoubiquitylation strongly decreases the biological activity of calmodulin towards phosphorylase kinase by reducing its affinity approximately threefold and the maximal degree of activation approximately twofold
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?
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine
[RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
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specific for Ca2+-calmodulin from vertebrates, at least 3 ubiquitin molecules can be coupled to lysine residues in calmodulin
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?
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine
[RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
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Saccharomyces cerevisiae enzyme conjugates ubiquitin to yeast and bovine calmodulin
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?
