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2.4.1.12: cellulose synthase (UDP-forming)

This is an abbreviated version!
For detailed information about cellulose synthase (UDP-forming), go to the full flat file.

Word Map on EC 2.4.1.12

Reaction

UDP-alpha-D-glucose
+
[(1->4)-beta-D-glucosyl]n
=
UDP
 +
[(1->4)-beta-D-glucosyl]n+1

Synonyms

1,4-beta-D-glucan synthase, 1,4-beta-glucan synthase, AcsA, AcsAB, AcsB, AtCesA7, BcsA-B, beta-1,4-glucan synthase, beta-1,4-glucan synthetase, beta-1,4-glucosyltransferase, beta-glucan synthase, cellulose syntethase, cellulose synthase, cellulose synthase (UDP-forming), cellulose synthase (uridine diphosphate-forming), cellulose synthase 2, cellulose synthase 3, cellulose synthase A, cellulose synthase A1, cellulose synthase A8, cellulose synthase complex, cellulose synthase-8, Ces A, CesA, CesA1, CesA2, CESA3, CESA4, CESA6, CESA7, CESA8, CSC, CSLD3, CslF, CslH, GhCesA1, glucan synthase, glucosyltransferase, uridine diphosphoglucose-1,4-beta-glucan, GS-I, GXY_04282, inner membrane-associated bacterial cellulose synthase, IRX3, More, UDP-glucose-1,4-beta-glucan glucosyltransferase, UDP-glucose-dependent beta-1,4-glucan synthase, UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase, UDPglucose-beta-glucan glucosyltransferase, UDPglucose-cellulose glucosyltransferase, uridine diphosphoglucose-cellulose glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.12 cellulose synthase (UDP-forming)

Engineering

Engineering on EC 2.4.1.12 - cellulose synthase (UDP-forming)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G998B
-
stable to the inhibitors: isoxaben and 5-tert-butyl-carbamoyloxy-3-(3-trifluormethyl)phenyl-4-thiazolidinone
T942I
-
stable to the inhibitors: isoxaben and 5-tert-butyl-carbamoyloxy-3-(3-trifluormethyl)phenyl-4-thiazolidinone
G998B
-
stable to the inhibitors: isoxaben and 5-tert-butyl-carbamoyloxy-3-(3-trifluormethyl)phenyl-4-thiazolidinone
-
T942I
-
stable to the inhibitors: isoxaben and 5-tert-butyl-carbamoyloxy-3-(3-trifluormethyl)phenyl-4-thiazolidinone
-
C37A
site-directed mutagenesis of the RING-motif leading to slightly decreased interaction with other CESA proteins, overview
C37A/C56A
site-directed mutagenesis of the RING-motif leading to decreased interaction with other CESA proteins, overview
C37A/C64A C37A/C79A
site-directed mutagenesis of the RING-motif leading to decreased interaction with other CESA proteins, overview
C56A
site-directed mutagenesis of the RING-motif leading to slightly decreased interaction with other CESA proteins, overview
C56A/C64A
site-directed mutagenesis of the RING-motif leading to decreased interaction with other CESA proteins, overview
C56A/C79A C64A/C79A
site-directed mutagenesis of the RING-motif leading to decreased interaction with other CESA proteins, overview
C64A
site-directed mutagenesis of the RING-motif leading to slightly decreased interaction with other CESA proteins, overview
C79A
site-directed mutagenesis of the RING-motif leading to slightly decreased interaction with other CESA proteins, overview
P578S
identification of thanatos, a semidominant mutant of Arabidopsis thaliana with impaired growth of seedlings due to a mutation in the catalytic domain of cellulose synthase 3, homozygous seedlings of than germinate and grow but do not survive, while heterozygous plants are dwarfed and display a radially swollen root phenotype, cellulose content is reduced by approximately one-fifth in heterozygous and by two-fifths in homozygous plants, overview. Gene dosage-dependent expression of the AtCesA3 mutant gene in wild-type Arabidopsis thaliana plants results in a than dominant-negative phenotype. The mutation alters the structure of the CESA3 catalytic domain
additional information