2.4.1.311: chloroorienticin B synthase
This is an abbreviated version!
For detailed information about chloroorienticin B synthase, go to the full flat file.
Reaction
Synonyms
chloroorienticin B synthase, GtfA
ECTree
2.4.1.311 chloroorienticin B synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.311 - chloroorienticin B synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dTDP-beta-L-4-epi-vancosamine + aglucovancomycin
dTDP + chloroorienticin C
low activity
-
-
?
dTDP-beta-L-4-epi-vancosamine + aglucovancomycin
dTDP + chloroorienticin C
low activity
-
-
?
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin
dTDP + chloroorienticin B
-
-
-
?
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin
dTDP + chloroorienticin B
-
-
-
?
dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin
dTDP + chloroorienticin B
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin
-
-
?
dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin
dTDP + chloroorienticin B
i.e. desvancosaminyl-vancomycin. Devancoaminyl vancomycin is the preferred acceptor for GtfA. GtfA is unable to use UDP-4-epi-vancosamine as the sugar substrate. GtfA catalyzes the addition of 4-epi-vancosamine to the hydroxyl group of beta-OH-Tyr-6 of devancoaminyl vancomycin. GtfA also transfers 4-epi-vancosamine to the 2-amino analogue of devancoaminyl vancomycin to produce the 2-amino analogue of chloroorienticin B
i.e. 4-epi-balhimicin
-
?
dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin
dTDP + chloroorienticin B
the enzyme is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin
-
-
?
dTDP-beta-L-4-epi-vancosamine + devancosaminyl-vancomycin
dTDP + chloroorienticin B
i.e. desvancosaminyl-vancomycin. Devancoaminyl vancomycin is the preferred acceptor for GtfA. GtfA is unable to use UDP-4-epi-vancosamine as the sugar substrate. GtfA catalyzes the addition of 4-epi-vancosamine to the hydroxyl group of beta-OH-Tyr-6 of devancoaminyl vancomycin. GtfA also transfers 4-epi-vancosamine to the 2-amino analogue of devancoaminyl vancomycin to produce the 2-amino analogue of chloroorienticin B
i.e. 4-epi-balhimicin
-
?
dTDP-beta-L-4-epi-vancosamine + epivancomycin
dTDP + chloroeremomycin
low activity
-
-
?
dTDP-beta-L-4-epi-vancosamine + epivancomycin
dTDP + chloroeremomycin
low activity
-
-
?
