2.4.1.313: protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

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For detailed information about protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

B3GALNT2, B3GalTN2, beta 1,3-N-acetylgalactosaminyltransferase2, beta-1,3-N-acetylgalactosaminyltransferase 2, beta1,3-N-acetylgalactosaminyltransferase II, beta1,3-N-acetylgalactosaminyltransferase-II, beta3GalNAc-T2, UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.313 protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

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Results	in table
6	AA Sequence
3	Application
1	Cloned(Commentary)
35	Disease/ Diagnostics
1	Expression
8	General Information
5	Localization
1	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
1	Posttranslational Modification
1	Reaction
9	Reference
13	Source Tissue
16	Substrates and Products (Substrate)
1	Subunits
15	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.4.1.313 - protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

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SYSTEMATIC NAME

IUBMB Comments

UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase

The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.