2.4.2.36: NAD+-diphthamide ADP-ribosyltransferase
This is an abbreviated version!
For detailed information about NAD+-diphthamide ADP-ribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.36
-
2.4.2.36
-
camp
-
cyclase
-
vibrio
-
mucosal
-
pertussis
-
adp-ribosylation
-
adenylate
-
forskolin
-
retrograde
-
gm1
-
ganglioside
-
aeruginosa
-
enterotoxin
-
iga
-
agonist
-
tracer
-
dorsal
-
prostaglandin
-
heat-labile
-
intranasal
-
dibutyryl
-
afferent
-
isoproterenol
-
adenylyl
-
g-proteins
-
innervation
-
gtp-binding
-
diphtheria
-
immunotoxins
-
anterograde
-
b-subunits
-
rostrally
-
toxigenic
-
ribosylation
-
pilus
-
toxin-induced
-
toxin-sensitive
-
pyrogenic
-
toxoid
-
8-bromo-camp
-
diarrheal
-
antitoxin
-
ventrolateral
-
peyer
-
exoenzyme
-
enterotoxigenic
-
gppnhp
-
preganglionic
-
drug development
-
wga-hrp
-
parabrachial
-
medicine
-
diagnostics
- 2.4.2.36
- camp
- cyclase
- vibrio
- mucosal
- pertussis
-
adp-ribosylation
- adenylate
- forskolin
-
retrograde
- gm1
- ganglioside
- aeruginosa
- enterotoxin
- iga
- agonist
-
tracer
-
dorsal
- prostaglandin
-
heat-labile
-
intranasal
-
dibutyryl
-
afferent
- isoproterenol
-
adenylyl
- g-proteins
-
innervation
-
gtp-binding
- diphtheria
- immunotoxins
-
anterograde
-
b-subunits
-
rostrally
-
toxigenic
-
ribosylation
- pilus
-
toxin-induced
-
toxin-sensitive
-
pyrogenic
- toxoid
- 8-bromo-camp
-
diarrheal
- antitoxin
-
ventrolateral
-
peyer
-
exoenzyme
-
enterotoxigenic
-
gppnhp
-
preganglionic
- drug development
-
wga-hrp
-
parabrachial
- medicine
- diagnostics
Reaction
Synonyms
(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2, ADP-ribosyltransferase, cholera toxin, cholix, cholix toxin, chxA, CTB, diphthamide-specific ADPRT, diphthamide-specific mono-ADP-ribosylating toxin, EHI 155600, EhToxin-l, EhToxin-like, ExoA, ExoA(c), exotoxin A, mono(ADPribosyl)transferase, mono-ADP-ribosyltransferase, NAD(+)-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase NAD-elongation factor 2 ADP-ribosyltransferase, NAD:elongation factor 2-adenosine diphosphate ribose-transferase
ECTree
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Turnover Number
Turnover Number on EC 2.4.2.36 - NAD+-diphthamide ADP-ribosyltransferase
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additional information
0.0062-0.13/min, wild-type GH activity, in the absence of eEF2, pH 7.9, 25°C, 60 min
additional information
NAD+
-
0.0062-0.13/min, wild-type GH activity, in the absence of eEF2, pH 7.9, 25°C, 60 min
additional information
NAD+
0.125 +/-0.007/min (a), wild-type GH activity, in the absence of eEF2, pH 7.9, 25°C, 60 min
additional information
NAD+
-
0.125 +/-0.007/min (a), wild-type GH activity, in the absence of eEF2, pH 7.9, 25°C, 60 min
additional information
NAD+
0.130 +/-0.012/min (b), wild-type GH activity, in the absence of eEF2, pH 7.9, 25°C, 60 min
additional information
NAD+
-
0.130 +/-0.012/min (b), wild-type GH activity, in the absence of eEF2, pH 7.9, 25°C, 60 min
additional information
NAD+
1306 +/-121/min (a), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
-
1306 +/-121/min (a), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
1495 +/-224/min (b), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
-
1495 +/-224/min (b), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
628 +/-8/min (B), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
-
628 +/-8/min (B), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
746 +/-18/min (A), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
-
746 +/-18/min (A), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
847 +/-21/min (C), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
-
847 +/-21/min (C), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
900 +/-20/min (D), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
-
900 +/-20/min (D), wild-type ADPRT activity, 12 microM eEF2, pH 7.9, 25°C, 300 sec
additional information
NAD+
double mutant E546A/R551A, kcat = 0.0001 +/-0.0001, relative to wild-type ADPRT activity (C)
additional information
NAD+
-
double mutant E546A/R551A, kcat = 0.0001 +/-0.0001, relative to wild-type ADPRT activity (C)
additional information
NAD+
double mutant E546A/R551A, kcat = 0.84 +/-0.04, relative to wild-type GH activity
additional information
NAD+
-
double mutant E546A/R551A, kcat = 0.84 +/-0.04, relative to wild-type GH activity
additional information
NAD+
double mutant E546D/R551K, kcat = 0.0009 +/-0.0013, relative to wild-type ADPRT activity (C)
additional information
NAD+
-
double mutant E546D/R551K, kcat = 0.0009 +/-0.0013, relative to wild-type ADPRT activity (C)
additional information
NAD+
double mutant E546D/R551K, kcat = 0.42 +/-0.0002, relative to wild-type GH activity
additional information
NAD+
-
double mutant E546D/R551K, kcat = 0.42 +/-0.0002, relative to wild-type GH activity
additional information
NAD+
double mutant E546R/R551E, kcat = 0.00001 +/-0.000002, relative to wild-type ADPRT activity (C)
additional information
NAD+
-
double mutant E546R/R551E, kcat = 0.00001 +/-0.000002, relative to wild-type ADPRT activity (C)
additional information
NAD+
double mutant E546R/R551E, kcat = 0.38 +/-0.01, relative to wild-type GH activity
additional information
NAD+
-
double mutant E546R/R551E, kcat = 0.38 +/-0.01, relative to wild-type GH activity
additional information
NAD+
mutant D461A, kcat = 1.001 +/-0.091, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant D461A, kcat = 1.001 +/-0.091, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant D461A, kcat = 1.076 +/-0.041, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant D461A, kcat = 1.076 +/-0.041, relative to wild-type GH activity (a)
additional information
NAD+
mutant D463A, kcat = 1.148 +/-0.038, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant D463A, kcat = 1.148 +/-0.038, relative to wild-type GH activity (a)
additional information
NAD+
mutant D463A, kcat = 1.270 +/-0.204, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant D463A, kcat = 1.270 +/-0.204, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant E546A, kcat = 0.0012 +/-0.00002, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant E546A, kcat = 0.0012 +/-0.00002, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant E546A, kcat = 0.24 +/-0.008, relative to wild-type GH activity
additional information
NAD+
-
mutant E546A, kcat = 0.24 +/-0.008, relative to wild-type GH activity
additional information
NAD+
mutant E546D, kcat = 0.00025 +/-0.00005, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant E546D, kcat = 0.00025 +/-0.00005, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant E546D, kcat = 0.45 +/-0.002, relative to wild-type GH activity
additional information
NAD+
-
mutant E546D, kcat = 0.45 +/-0.002, relative to wild-type GH activity
additional information
NAD+
mutant E546F, kcat = 0.007 +/-0.0002, relative to wild-type ADPRT activity (D)
additional information
NAD+
-
mutant E546F, kcat = 0.007 +/-0.0002, relative to wild-type ADPRT activity (D)
additional information
NAD+
mutant E546F, kcat = 0.69 +/-0.05, relative to wild-type GH activity
additional information
NAD+
-
mutant E546F, kcat = 0.69 +/-0.05, relative to wild-type GH activity
additional information
NAD+
mutant E546H, kcat = 0.0012 +/-0.0002, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant E546H, kcat = 0.0012 +/-0.0002, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant E546H, kcat = 0.59 +/-0.009, relative to wild-type GH activity
additional information
NAD+
-
mutant E546H, kcat = 0.59 +/-0.009, relative to wild-type GH activity
additional information
NAD+
mutant E546N, kcat = 0.0010 +/-0.00009, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant E546N, kcat = 0.0010 +/-0.00009, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant E546N, kcat = 0.67 +/-0.03, relative to wild-type GH activity
additional information
NAD+
-
mutant E546N, kcat = 0.67 +/-0.03, relative to wild-type GH activity
additional information
NAD+
mutant E546Q, kcat = 0.011 +/-0.002, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant E546Q, kcat = 0.011 +/-0.002, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant E546Q, kcat = 0.80 +/-0.04, relative to wild-type GH activity
additional information
NAD+
-
mutant E546Q, kcat = 0.80 +/-0.04, relative to wild-type GH activity
additional information
NAD+
mutant E547A, kcat = 0.795 +/-0.077, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant E547A, kcat = 0.795 +/-0.077, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant E547A, kcat = 0.83 +/-0.14, relative to wild-type GH activity
additional information
NAD+
-
mutant E547A, kcat = 0.83 +/-0.14, relative to wild-type GH activity
additional information
NAD+
mutant E548A, kcat = 0.76 +/-0.01, relative to wild-type GH activity
additional information
NAD+
-
mutant E548A, kcat = 0.76 +/-0.01, relative to wild-type GH activity
additional information
NAD+
mutant E548A, kcat = 1.669 +/-0.298, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant E548A, kcat = 1.669 +/-0.298, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant E553A, kcat = 0.0015 +/-0.00005, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant E553A, kcat = 0.0015 +/-0.00005, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant E553A, kcat = 0.07 +/-0.009, relative to wild-type GH activity
additional information
NAD+
-
mutant E553A, kcat = 0.07 +/-0.009, relative to wild-type GH activity
additional information
NAD+
mutant G453A, kcat = 0.290 +/-0.040, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant G453A, kcat = 0.290 +/-0.040, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant G453A, kcat = 0.331 +/-0.019, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant G453A, kcat = 0.331 +/-0.019, relative to wild-type GH activity (a)
additional information
NAD+
mutant G454A, kcat = 0.031 +/-0.003, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant G454A, kcat = 0.031 +/-0.003, relative to wild-type GH activity (a)
additional information
NAD+
mutant G454A, kcat = 0.046 +/-0.008, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant G454A, kcat = 0.046 +/-0.008, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant G549A, kcat = 0.30 +/-0.005, relative to wild-type GH activity
additional information
NAD+
-
mutant G549A, kcat = 0.30 +/-0.005, relative to wild-type GH activity
additional information
NAD+
mutant G549A, kcat = 0.770 +/-0.076, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant G549A, kcat = 0.770 +/-0.076, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant G550A, kcat = 0.41 +/-0.04, relative to wild-type GH activity
additional information
NAD+
-
mutant G550A, kcat = 0.41 +/-0.04, relative to wild-type GH activity
additional information
NAD+
mutant G550A, kcat = 0.562 +/-0.166, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant G550A, kcat = 0.562 +/-0.166, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant L462A, kcat = 0.268 +/-0.041, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant L462A, kcat = 0.268 +/-0.041, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant L462A, kcat = 0.955 +/-0.015, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant L462A, kcat = 0.955 +/-0.015, relative to wild-type GH activity (a)
additional information
NAD+
mutant L552A, kcat = 0.58 +/-0.002, relative to wild-type GH activity
additional information
NAD+
-
mutant L552A, kcat = 0.58 +/-0.002, relative to wild-type GH activity
additional information
NAD+
mutant L552A, kcat = 2.365 +/-0.527, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant L552A, kcat = 2.365 +/-0.527, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant Q460A, kcat = 0.115 +/-0.010, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant Q460A, kcat = 0.115 +/-0.010, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant Q460A, kcat = 0.622 +/-0.014, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant Q460A, kcat = 0.622 +/-0.014, relative to wild-type GH activity (a)
additional information
NAD+
mutant R456A, kcat = 0.230 +/-0.010, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant R456A, kcat = 0.230 +/-0.010, relative to wild-type GH activity (a)
additional information
NAD+
mutant R456A, kcat = 0.239 +/-0.034, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant R456A, kcat = 0.239 +/-0.034, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant R458A, kcat = 0.132 +/-0.031, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant R458A, kcat = 0.132 +/-0.031, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant R458A, kcat = 0.249 +/-0.021, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant R458A, kcat = 0.249 +/-0.021, relative to wild-type GH activity (a)
additional information
NAD+
mutant R458H, kcat = 0.018 +/-0.003, relative to wild-type GH activity (b)
additional information
NAD+
-
mutant R458H, kcat = 0.018 +/-0.003, relative to wild-type GH activity (b)
additional information
NAD+
mutant R458H, kcat = 0.019 +/-0.007, relative to wild-type ADPRT activity (b)
additional information
NAD+
-
mutant R458H, kcat = 0.019 +/-0.007, relative to wild-type ADPRT activity (b)
additional information
NAD+
mutant R458K, kcat = 0.428 +/-0.033, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant R458K, kcat = 0.428 +/-0.033, relative to wild-type GH activity (a)
additional information
NAD+
mutant R458K, kcat = 0.543 +/-0.155, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant R458K, kcat = 0.543 +/-0.155, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant R458Q, kcat = 0.650 +/-0.130, relative to wild-type ADPRT activity (b)
additional information
NAD+
-
mutant R458Q, kcat = 0.650 +/-0.130, relative to wild-type ADPRT activity (b)
additional information
NAD+
mutant R458Q, kcat = 0.991 +/-0.017, relative to wild-type GH activity (b)
additional information
NAD+
-
mutant R458Q, kcat = 0.991 +/-0.017, relative to wild-type GH activity (b)
additional information
NAD+
mutant R458W, kcat = 0.379 +/-0.043, relative to wild-type ADPRT activity (b)
additional information
NAD+
-
mutant R458W, kcat = 0.379 +/-0.043, relative to wild-type ADPRT activity (b)
additional information
NAD+
mutant R458W, kcat = 0.438 +/-0.040, relative to wild-type GH activity (b)
additional information
NAD+
-
mutant R458W, kcat = 0.438 +/-0.040, relative to wild-type GH activity (b)
additional information
NAD+
mutant R551A, kcat = 0.32 +/-0.005, relative to wild-type GH activity
additional information
NAD+
-
mutant R551A, kcat = 0.32 +/-0.005, relative to wild-type GH activity
additional information
NAD+
mutant R551A, kcat = 0.380 +/-0.024, relative to wild-type ADPRT activity (A)
additional information
NAD+
-
mutant R551A, kcat = 0.380 +/-0.024, relative to wild-type ADPRT activity (A)
additional information
NAD+
mutant R551C, kcat = ~0, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant R551C, kcat = ~0, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant R551C, kcat = 0.10 +/-0.006, relative to wild-type GH activity
additional information
NAD+
-
mutant R551C, kcat = 0.10 +/-0.006, relative to wild-type GH activity
additional information
NAD+
mutant R551E, kcat = 0.011 +/-0.005, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant R551E, kcat = 0.011 +/-0.005, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant R551E, kcat = 0.09 +/-0.001, relative to wild-type GH activity
additional information
NAD+
-
mutant R551E, kcat = 0.09 +/-0.001, relative to wild-type GH activity
additional information
NAD+
mutant R551H, kcat = ~0, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant R551H, kcat = ~0, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant R551H, kcat = 0.41 +/-0.002, relative to wild-type GH activity
additional information
NAD+
-
mutant R551H, kcat = 0.41 +/-0.002, relative to wild-type GH activity
additional information
NAD+
mutant R551K, kcat = 0.317 +/-0.024, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant R551K, kcat = 0.317 +/-0.024, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant R551K, kcat = 0.69 +/-0.03, relative to wild-type GH activity
additional information
NAD+
-
mutant R551K, kcat = 0.69 +/-0.03, relative to wild-type GH activity
additional information
NAD+
mutant R551Q, kcat = 0.185 +/-0.014, relative to wild-type ADPRT activity (B)
additional information
NAD+
-
mutant R551Q, kcat = 0.185 +/-0.014, relative to wild-type ADPRT activity (B)
additional information
NAD+
mutant R551Q, kcat = 0.38 +/-0.01, relative to wild-type GH activity
additional information
NAD+
-
mutant R551Q, kcat = 0.38 +/-0.01, relative to wild-type GH activity
additional information
NAD+
mutant S459A, kcat = 1.119 +/-0.054, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant S459A, kcat = 1.119 +/-0.054, relative to wild-type GH activity (a)
additional information
NAD+
mutant S459A, kcat = 1.256 +/-0.144, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant S459A, kcat = 1.256 +/-0.144, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant V455A, kcat = 0.241 +/-0.032, relative to wild-type ADPRT activity (a)
additional information
NAD+
-
mutant V455A, kcat = 0.241 +/-0.032, relative to wild-type ADPRT activity (a)
additional information
NAD+
mutant V455A, kcat = 0.254 +/-0.001, relative to wild-type GH activity (a)
additional information
NAD+
-
mutant V455A, kcat = 0.254 +/-0.001, relative to wild-type GH activity (a)
additional information
NAD+
relative kcat = 1.00 +/-0.02, wild-type GH activity
additional information
NAD+
-
relative kcat = 1.00 +/-0.02, wild-type GH activity
additional information
NAD+
relative kcat = 1.00 +/-0.05, wild-type GH activity (a) and (b)
additional information
NAD+
-
relative kcat = 1.00 +/-0.05, wild-type GH activity (a) and (b)
additional information
NAD+
relative kcat = 1.00 +/-0.09, wild-type ADPRT activity (A)-(D), and (a) and (b)
additional information
NAD+
-
relative kcat = 1.00 +/-0.09, wild-type ADPRT activity (A)-(D), and (a) and (b)