2.5.1.114: tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

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For detailed information about tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, go to the full flat file.

Reaction

7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe

Synonyms

MJ1557, PH0793, TRM12, TYW2, YML005w

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.114 tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

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Results	in table
3133	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
1	Expression
3	General Information
2	Natural Substrates/ Products (Substrates)
4	Organism
1	Pathway
5	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reference
4	Substrates and Products (Substrate)
7	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.5.1.114 - tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase

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S-adenosyl-L-methionine:tRNAPhe (4-demethylwyosine37-C7) [(3S)-3-amino-3-carboxypropyl]transferase

The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe.