2.5.1.132: 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase
This is an abbreviated version!
For detailed information about 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase, go to the full flat file.
Reaction
Synonyms
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase, 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase, 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase, BT1714, KDN 9-phosphate synthase, KDN-9-P synthase, KDN-9-phosphate synthetase, KDN-9P synthase, N-acetylneuraminic acid phosphate synthase, Neu5Ac 9-phosphate synthase, neu5ac-9-P synthase, NeuNAc-9-P synthase
ECTree
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Engineering
Engineering on EC 2.5.1.132 - 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase
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M42L
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the M42L mutant of N-acetylneuraminic acid-9-phosphate synthase, like the wild type enzyme, shows the additional 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid-9-phosphate synthase activity
M42T
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the mutation of N-acetylneuraminic acid-9-phosphate synthase abolishes its 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid-9-phosphate synthase activity
R96K/R100S/E103Q/V105I/V195A
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the mutant of N-acetylneuraminic acid-9-phosphate synthase has significant 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid-9-phosphate synthase activity
additional information
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replacement of the antifreeze-like domain of human N-acetylneuraminic acid phosphate synthase with the mouse antifreeze-like domain impacts both N-acetylneuraminic acid 9-phosphate synthase and 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activities