2.5.1.25: tRNA-uridine aminocarboxypropyltransferase

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For detailed information about tRNA-uridine aminocarboxypropyltransferase, go to the full flat file.

Reaction

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.25 tRNA-uridine aminocarboxypropyltransferase

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Results	in table
13303	AA Sequence
1	Metals/Ions
177	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
2	Reference
2	Substrates and Products (Substrate)
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.5.1.25 - tRNA-uridine aminocarboxypropyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:uridine in tRNA 3-[(3S)-3-amino-3-carboxypropyl]transferase

3-[(3S)-3-amino-3-carboxypropyl]uridine (acp3U) is a highly conserved modification found in tRNA core region in bacteria and eukaryotes that confers thermal stability on tRNA. The enzyme from the bacterium Escherichia coli catalyses the modification of uridine47 in the V-loop of tRNAs for Arg2, Ile1, Ile2, Ile2v, Lys, Met, Phe, Val2A, and Val2B. The human homologs DTWD1 and DTWD2 are responsible for acp3U formation at positions 20 and 20a, respectively, in the D-loop of several cytoplasmic tRNAs.