2.5.1.B21: S-adenosyl-L-methionine hydroxide adenosyltransferase
This is an abbreviated version!
For detailed information about S-adenosyl-L-methionine hydroxide adenosyltransferase, go to the full flat file.
Reaction
Synonyms
duf-62, duf62, SAM hydroxide adenosyltransferase
ECTree
2.5.1.B21 S-adenosyl-L-methionine hydroxide adenosyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.5.1.B21 - S-adenosyl-L-methionine hydroxide adenosyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5'-deoxy-5'-chloroadenosine + H2O
adenosine + ?
adenosine is generated from 5'-deoxy-5'-chloroadenosine with much lower efficiency than from S-adenosyl-L-methionine
-
-
?
5'-deoxy-5'-chloroadenosine + H2O
adenosine + ?
adenosine is generated from 5'-deoxy-5'-chloroadenosine with much lower efficiency than from S-adenosyl-L-methionine
-
-
?
S-adenosyl-L-methionine + H2O
adenosine + L-methionine + H+
the enzyme is most active at pH 8.5, so perhaps it has a regulatory role in influencing the cellular pH in the host organism. Many, but not all of the duf-62 containing organisms are extremophiles
-
-
?
S-adenosyl-L-methionine + H2O
adenosine + L-methionine + H+
conversion of S-adenosyl-L-methionine into adenosine by the attack of a hydroxide ion from water at C5 of S-adenosyl-L-methionine. No new products are detected by HPLC or NMR spectroscopy after the incubation of the enzyme with S-adenosyl-L-methionine and F-, Cl-, or NH4+ ions at high mM concentrations. In all cases adenosine is generated in a manner consistent with normal enzymatic turnover, with water providing the nucleophil
-
-
?
S-adenosyl-L-methionine + H2O
adenosine + L-methionine + H+
mechanistic hypothesis for SAM hydroxide adenosyltransferase
-
-
?
S-adenosyl-L-methionine + H2O
adenosine + L-methionine + H+
the amino acid Asp-Arg-His triad and particularly the Asp-Arg ion pair appears to play an important role in holding the water for nucleophilic attack as S-adenosyl-L-methionine binds and becomes proximate
-
-
?
S-adenosyl-L-methionine + H2O
adenosine + L-methionine + H+
conversion of S-adenosyl-L-methionine into adenosine by the attack of a hydroxide ion from water at C5 of S-adenosyl-L-methionine. No new products are detected by HPLC or NMR spectroscopy after the incubation of the enzyme with S-adenosyl-L-methionine and F-, Cl-, or NH4+ ions at high mM concentrations. In all cases adenosine is generated in a manner consistent with normal enzymatic turnover, with water providing the nucleophil
-
-
?
