2.6.1.27: tryptophan transaminase
This is an abbreviated version!
For detailed information about tryptophan transaminase, go to the full flat file.
Word Map on EC 2.6.1.27
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2.6.1.27
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auxin
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iaa
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indole-3-pyruvic
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tryptamine
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indolepyruvate
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gravitropism
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indole-3-acetaldehyde
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l-kynurenine
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tryptophan-dependent
- 2.6.1.27
- auxin
- iaa
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indole-3-pyruvic
- tryptamine
- indolepyruvate
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gravitropism
- indole-3-acetaldehyde
- l-kynurenine
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tryptophan-dependent
Reaction
Synonyms
5-hydroxytryptophan-ketoglutaric transaminase, aminotransferase, tryptophan, FIB, hydroxytryptophan aminotransferase, L-phenylalanine-2-oxoglutarate aminotransferase, L-tryptophan aminotransferase, L-tryptophan transaminase, L-tryptophan-pyruvate aminotransferase 1, LmTAM1, OsTAR1, protein FIB, protein FISH BONE, TAA, TAA1, Tam1, TAR1, TAR2, Trp-dependent aminotransferase, tryptophan aminotransferase, tryptophan aminotransferase of Arabidopsis 1, TSG1, vanishing tassel2, vt2
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2.6.1.27 tryptophan transaminaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.6.1.27 - tryptophan transaminase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2-(aminooxy)-3-(naphthalen-2-yl)propanoic acid
KOK1169/AONP, the compound is an improved, that is more specific for TAA1 than for other enzymes, such as phenylalanine ammonia-lyase. KOK1169 inhibits TAA1 in a competitive manner
L-kynurenine
competitively inhibits TAA1/TAR activity, and Kyn treatment mimicks the loss of TAA1/TAR functions; competitively inhibits TAA1/TAR activity, and Kyn treatment mimicks the loss of TAA1/TAR functions
p-chloromercuribenzoate
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reduced by preincubation with L-phenylalanine and pyridoxal phosphate and reversed by a subsequent preincubation with 2-mercaptoethanol
additional information
aminooxy-naphthylpropionic acid and derivatives are inhibitors of auxin biosynthesis targeting L-tryptophan aminotransferase, structure-activity relationships, overview. Synthesis of potential inhibitors and docking simulation analysis including KOK1169/AONP. The developed compounds constitute a class of inhibitors of TAA1, designated as pyruvamine
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additional information
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not affected by metal chelators and high concentration of ammonium sulfate; reduced activity in cacodylate, Tris and borate buffers
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