2.7.1.150: 1-phosphatidylinositol-3-phosphate 5-kinase

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For detailed information about 1-phosphatidylinositol-3-phosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.1.150

2.7.1.150

mating

pheromone

vacuole

endosomal

ptdins3,5p2

haploid

3,5-bisphosphate

ptdins5p

endolysosomal

apilimod

pheromone-induced

pseudohyphal

phosphatidylinositol-3,5-bisphosphate

pheromone-responsive

charcot-marie-tooth

mating-type

mating-specific

fleck

alpha-specific

matalpha

a-specific

trpml1

a-factor

insulin-regulated

drug development

Reaction

1-phosphatidyl-1D-myo-inositol 3-phosphate

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate

Synonyms

CgFab1, class III lipid kinase, Fab1, Fab1 phosphatidylinositol 3-phosphate 5-kinase, FAB1/FYVE finger-containing phosphoinositide kinase, Fab1/PIKfyve, Fab1p, formation of aploid and binucleate cells1/FYVE finger-containing phosphoinositide kinase, FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase, kinase (phosphorylating), phosphatidylinositol 3-phosphate 5-, More, phosphatidylinositol 3-phosphate 5-kinase, phosphatidylinositol 5-OH kinase, phosphatidylinositol phosphate kinase 3, Phosphatidylinositol-3-phosphate 5-kinase, phosphatidylinositol-3-phosphate-5-kinase PIKfyve, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PI(3)P-5-kinase, PI-3P-5-kinase, PI3P 5-kinase, PI3P-5 kinase, PIKfyve, PIKfyve/Fab1p, PIP5K3, PPK-3, PtdIns 3-phosphate 5-kinase, PtdIns(3) 5-kinase, PtdIns(3)P 5-kinase, PtdIns3P 5-kinase, PtdIns3P 5-OH kinase, Ste12, type III PIP kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase

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6	Activating Compound
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8	Cofactor
251	Disease/ Diagnostics
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33	Reference
14	Source Tissue
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96	Synonyms
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Inhibitors

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Inhibitors on EC 2.7.1.150 - 1-phosphatidylinositol-3-phosphate 5-kinase

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apilimod

Homo sapiens

Q9Y2I7

an inhibitor of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve, and potent inhibitor of SARS-CoV-2 strain 2019-nCoV/USA-WA1/2020. The compound prevents cytoplasmic entry of MeGFP-tagged vesicular stomatitis virus (VSV)-ebolavirus (EBOV) construct VSV-MeGFP-ZEBOV, inhibition of VSV mutant entry, overview. The virus particles are able to enter functional endosomes in presence of apilimod; HY-14644, apilimod inhibits enzyme PIKfyve and infection of SARS-CoV-2 virus. The IC50 of apilimod in experiments with authentic virus is remarkably similar to (or even more potent than) that obtained with chimeric VSV-SARS-CoV-2

762289

vacuolin-1

Homo sapiens

Q9Y2I7

an inhibitor of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve. The compound prevents cytoplasmic entry of MeGFP-tagged vesicular stomatitis virus (VSV)-ebolavirus (EBOV) construct VSV-MeGFP-ZEBOV, inhibition of VSV mutant entry, overview; vacuolin-1 inhibits enzyme PIKfyve

762289

YM201636

3 entries