2.7.1.82: ethanolamine kinase

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For detailed information about ethanolamine kinase, go to the full flat file.

Reaction

Synonyms

CEK4, choline/ethanolamine kinase, EKI, EKI1, ethanolamine kinase, ethanolamine kinase 1, ethanolamine kinase 2, ethanolamine phosphokinase, Etn kinase, EtnK, ETNK1, Etnk2, kinase, ethanolamine (phosphorylating), More, PfEK, Treki1

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.82 ethanolamine kinase

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Results	in table
4	Activating Compound
190	AA Sequence
2	Application
1	CAS Registry Number
18	Cloned(Commentary)
7	Cofactor
76	Disease/ Diagnostics
3	Expression
15	General Information
1	General Stability
7	IC50 Value
78	Inhibitors
1	Ki Value [mM]
31	KM Value [mM]
23	Localization
30	Metals/Ions
25	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
65	Organism
7	Pathway
34	PDB ID
10	pH Optimum
2	pH Range
12	Protein Variants
7	Purification (Commentary)
18	Reaction
2	Reaction Type
53	Reference
61	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
91	Substrates and Products (Substrate)
11	Subunits
53	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
3	Turnover Number [1/s]

Expression

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Expression on EC 2.7.1.82 - ethanolamine kinase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

expression levels increases during erythrocytic development

Plasmodium falciparum 3D7

Q8IIB7

702145

substantial induction of splicing variant ek2alpha mRNA expression in response to trichostatin A treatment in Hep-G2 cells, the elevated ek2alpha mRNA expression may be due to the accumu­lation of acetylated histones H3 and H4, located around the promoter regions. Trichostatin A may also induce the recruit­ment of euchromatic markers and RNA polymerase II to the transcription factor complex that binds to the promoter, thus facilitating gene transcription

Homo sapiens

Q9HBU6, Q9NVF9

739083

treatment of HCT-116 cells with trichostatin A (TSA), a histone deacetylase inhibitor, significantly upregulates the eki1 promoter activity through the Sp(-40/-31) site and increases the endogenous expression of gene eki1. Trichostatin A increases the binding of Sp1, Sp3 and RNA polymerase II to the ek1 promoter in HCT116 cells, molecular mechanism, overview. The effect of TSA on ek1 promoter activity is cell-line specific as TSA treatment does not affect ek1 promoter activity in Hep-G2 cells

Homo sapiens

Q9HBU6

739440