2.7.1.89: thiamine kinase

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For detailed information about thiamine kinase, go to the full flat file.

Reaction

Synonyms

ATP:thiamin phosphotransferase, kinase, thiamin (phosphorylating), thiamin kinase, thiamin kinase (phosphorylating), thiamin phosphokinase, ThiK, YcfN

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.89 thiamine kinase

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1	Activating Compound
1888	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
2	Cofactor
3	General Information
1	KM Value [mM]
1	Localization
3	Metals/Ions
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organism
5	Pathway
1	pH Optimum
1	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
5	Substrates and Products (Substrate)
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

General Information

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General Information on EC 2.7.1.89 - thiamine kinase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Escherichia coli

P75948

a thiK deletion strain (DELTAthiK) reveals decreased thiamine sensitivity, since this enzyme is required for the phosphorylation of thiamine to thiamine diphosphate. Deleting the thiamine kinase ThiK abolishes thiamine and triazolethiamine-dependent inhibition of reporter gene expression. The reporter gene expression in the thiK deletion strain is dramatically decreased in the presence of pyrithiamine

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metabolism

Escherichia coli

P75948

thiamine is synthesized from two precursors, hydroxymethylpyrimidine diphosphate and hydroxyethylthiazole phosphate, which are produced independently and finally joined to form thiamine phosphate

738286

physiological function

Escherichia coli

P75948

riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. TPP-riboswitches, which respond to thiamine diophosphate, are involved in the regulation of thiamine metabolism. Thiamine analogues containing a central 1,2,3-triazole group induce repression of thiM-riboswitch dependent gene expression in different Escherichiac coli strains. Triazolethiamine shows concentration-dependent reporter gene repression that is dependent on the presence of thiamine kinase ThiK, whereas the effect of pyrithiamine, a known TPP-riboswitch modulator, is ThiK-independent, overview. ThiK dependency is bypassed by triazolethiamine-derivatives that bear phosphate mimicking and metal-ion chelating moieties

738286