2.7.4.29: Kdo2-lipid A phosphotransferase
This is an abbreviated version!
For detailed information about Kdo2-lipid A phosphotransferase, go to the full flat file.
Reaction
Synonyms
lipid A undecaprenyl phosphotransferase, LptX, LpxT, PA14_68620
ECTree
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General Information
General Information on EC 2.7.4.29 - Kdo2-lipid A phosphotransferase
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physiological function
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a chromosomal deletion mutant cannot phosphorylate lipid A
physiological function
enzyme LpxT-catalysed phosphorylation is dependent upon transport of lipid A across the inner membrane by MsbA, a lipid A flippase
physiological function
effect of LpxT ectopic expression from a plasmid in Escherichia coli. LpxT induction inhibits cell division and leads to the formation of elongated cells, mostly with absent or altered septa. The cells become sensitive to detergents and to hypoosmotic shock. LpxT overexpression in mutants lacking the L,D-transpeptidase LdtD and LdtE causes cell envelope defects. Diphosphorylated lipid A is also produced in a LpxT deletion mutant
physiological function
enzyme is able to complement an Escherichia coli LpxT mutant. In Pseudomonas aeruginosa, an LpxT deletion mutant cannot phosphorylate lipid A
physiological function
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enzyme is able to complement an Escherichia coli LpxT mutant. In Pseudomonas aeruginosa, an LpxT deletion mutant cannot phosphorylate lipid A
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