2.7.4.7: phosphooxymethylpyrimidine kinase
This is an abbreviated version!
For detailed information about phosphooxymethylpyrimidine kinase, go to the full flat file.
Word Map on EC 2.7.4.7
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2.7.4.7
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thiamin
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auxotrophic
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hydroxyethylthiazole
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pyrophosphate
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2.7.1.35
- 2.7.4.7
- thiamin
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auxotrophic
- hydroxyethylthiazole
- pyrophosphate
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2.7.1.35
Reaction
Synonyms
2-methyl-4-amino-5-hydroxymethylpyrimidine monophosphate kinase, CCC13826_0338, CcThiD2, HMP-P kinase, HMP/HMP phosphate kinase, HMPPK, HVO_2666, hydroxymethylpyrimidine phosphate kinase, hydroxymethylpyrimidine phosphokinase, kinase, phosphomethylpyrimidine (phosphorylating), More, phosphomethylpyrimidine kinase, StHMPPK, Suden_2055, TdThiD2, Thi20, Thi20p, Thi20p protein, Thi21p protein, thiamine phosphate synthase, ThiD, ThiD2, ThiD2 domain-containing protein, TTHA0680, TtHMPPK
ECTree
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Engineering
Engineering on EC 2.7.4.7 - phosphooxymethylpyrimidine kinase
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additional information
complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2. Strains expressing a standalone ThiD2 protein are 10fold more resistant than wild-type against bacimethrin toxicity. ThiD2 genes confer resistance to bacimethrin
additional information
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complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2. Strains expressing a standalone ThiD2 protein are 10fold more resistant than wild-type against bacimethrin toxicity. ThiD2 genes confer resistance to bacimethrin
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additional information
construction of a thiD knockout mutant strain, complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2, ThiD2 proteins catalyze phosphorylation of HMP monophosphate, but not of HMP or its toxic analogues and damage products such as bacimethrin and 5-(hydroxymethyl)-2-methylpyrimidin-4-ol. As strictly monofunctional HMP monophosphate kinases (EC 2.7.4.7), ThiD2 proteins eliminate a potentially fatal vulnerability of canonical ThiD, at the cost of the ability to reclaim HMP formed by thiamin turnover
additional information
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construction of a thiD knockout mutant strain, complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2, ThiD2 proteins catalyze phosphorylation of HMP monophosphate, but not of HMP or its toxic analogues and damage products such as bacimethrin and 5-(hydroxymethyl)-2-methylpyrimidin-4-ol. As strictly monofunctional HMP monophosphate kinases (EC 2.7.4.7), ThiD2 proteins eliminate a potentially fatal vulnerability of canonical ThiD, at the cost of the ability to reclaim HMP formed by thiamin turnover
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additional information
complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2. Strains expressing a standalone ThiD2 protein are 10fold more resistant than wild-type against bacimethrin toxicity. ThiD2 genes confer resistance to bacimethrin
additional information
-
complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2. Strains expressing a standalone ThiD2 protein are 10fold more resistant than wild-type against bacimethrin toxicity. ThiD2 genes confer resistance to bacimethrin
-
additional information
-
complementation of the Escherichia coli DELTA thiD knockout mutant is possible by heterologous expression of gene ThiD2. Strains expressing a standalone ThiD2 protein are 10fold more resistant than wild-type against bacimethrin toxicity. ThiD2 genes confer resistance to bacimethrin
-