Information on EC 1.14.12.19 - 3-phenylpropanoate dioxygenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.12.19
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RECOMMENDED NAME
GeneOntology No.
3-phenylpropanoate dioxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E)-3-phenylprop-2-enoate + NADH + H+ + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD+
show the reaction diagram
(2)
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3-phenylpropanoate + NADH + H+ + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
show the reaction diagram
; (1)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation to 2-oxopent-4-enoate
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cinnamate and 3-hydroxycinnamate degradation to 2-oxopent-4-enoate
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3-phenylpropionate degradation
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Phenylalanine metabolism
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate.
CAS REGISTRY NUMBER
COMMENTARY hide
105503-66-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain K12 and enzyme deficiency strains obtained from mutagenesis with ethylmethane sulfonate
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Manually annotated by BRENDA team
strain KK334
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Manually annotated by BRENDA team
TT01R strains
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Manually annotated by BRENDA team
TT01R strains
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-phenylpropionate + NADH + O2
3-(2,3-dihydroxyphenyl)propionate + NAD+
show the reaction diagram
3-phenylpropionate + NADH + O2
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
show the reaction diagram
3-phenylpropionate + NADH + O2
3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dien-1-yl]propanoic acid + NAD+
show the reaction diagram
3-phenylpropionate + NADH + O2 + H+
3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dien-1-yl]propanoic acid + NAD+
show the reaction diagram
cinnamic acid + NADH + O2 + H+
cinnamic acid-2,3-dihydrodiol + NAD+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-phenylpropionate + NADH + O2
3-(2,3-dihydroxyphenyl)propionate + NAD+
show the reaction diagram
3-phenylpropionate + NADH + O2
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
show the reaction diagram
3-phenylpropionate + NADH + O2
3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dien-1-yl]propanoic acid + NAD+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cinnamic acid
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induces the expression of the hca operon, the plu2201 and plu2202 genes, and stlA expression
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
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gene products from hcaA1, hcaA2, hcaC and hcaD, 1 * 51109 + 1 * 20579 + 1 * 11328 + 1 * 43978, subunit masses calculated from deduced amino acid sequences
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Salmonella typhimurium
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Show AA Sequence (576 entries)
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