Information on EC 2.1.1.3 - thetin-homocysteine S-methyltransferase

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The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY hide
2.1.1.3
-
RECOMMENDED NAME
GeneOntology No.
thetin-homocysteine S-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dimethylsulfonioacetate + L-homocysteine = S-methylthioglycolate + L-methionine
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
dimethylsulfonioacetate:L-homocysteine S-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9029-76-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dimethylthetin + L-homocysteine
S-methylthioglycolate + L-methionine
show the reaction diagram
additional information
?
-
-
methyl group donors are ethylmethylthetin, dimethyl-alpha- and dimethyl-beta-propiothetin, ethylmethyl-beta-propiothetin, dimethyl-gamma-butyrothetin, methionine methylsulfonium, trimethylsulfonium, ethyldimethylsulfonium or butyldimethylsulfonium, no acceptors are cysteamine, 2-mercaptoethanol, DL-homocystine, sodium mercaptoacetate
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-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dimethylthetin + L-homocysteine
S-methylthioglycolate + L-methionine
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
no activation by metal ions
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
-
0.01 M, strong
glycine betaine
-
0.1 M
Hg2+
-
0.01 M, strong
hydroxylamine
-
0.01 M
phenylhydrazine
-
0.01 M
Sodium mercaptoacetate
-
-
Zn2+
-
0.01 M, strong
additional information
-
no inhibition by dimethylthetin, sulfocholine (up to 0.1 M), mercaptoethanol, cysteine, Na2SO4, Li+, Cs+, Ca2+, Mg2+, NaN3, NaCN, NaF, EDTA, semicarbazide, iodoacetate
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5.3
DL-homocysteine
-
-
10.2
thetin
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, several weeks
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE