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Disease on EC 2.3.1.39 - [acyl-carrier-protein] S-malonyltransferase

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DISEASE
TITLE OF PUBLICATION
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Aberrant Crypt Foci
Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane.
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Acidosis
In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells.
Acute Coronary Syndrome
Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome.
[Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome].
Acute Lung Injury
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
Adenocarcinoma
A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients.
Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells.
Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.
Evaluation of fatty acid synthase expression in oesophageal mucosa of patients with oesophagitis, Barrett's oesophagus and adenocarcinoma.
Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma.
Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence.
Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function.
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma?: A comparison with AMACR.
Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Adenocarcinoma of Lung
Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models.
Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma.
Adenoma
Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
P53 as a marker of differentiation between hyperplastic and adenomatous parathyroids.
Adenoma, Pleomorphic
Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors.
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Alzheimer Disease
CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease.
Ameloblastoma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Arthritis
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
Ataxia
The double dealing of cyclin D1.
Atherosclerosis
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Protective effect of atorvastatin meditated by HMGCR gene on diabetic rats with atherosclerosis: An in vivo and in vitro study.
Azotemia
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Barrett Esophagus
Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis.
Blindness
MCAT Mutations Cause Nuclear LHON-like Optic Neuropathy.
Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.
Breast Neoplasms
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity.
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.
A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction.
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells.
Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.
Antitumor effects of curcumin: A lipid perspective.
Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells.
Application of chromatography technology in the separation of active alkaloids from Hypecoum leptocarpum and their inhibitory effect on fatty acid synthase.
Aromatase, CYP1B1 and Fatty Acid Synthase Expression in Breast Tumors of BRCA1 Mutation Carriers.
Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells.
Breast Cancer Brain Metastases Rely on FASN-Mediated Lipid Biosynthesis.
Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids.
Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway.
Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue.
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.
Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells.
Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis.
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.
Dietary fatty acids affect lipid metabolism and estrogen receptor expression in N-methyl-N-nitrosourea-induced rat mammary cancer model.
Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.
DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line.
Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.
Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells.
Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype.
Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China.
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study.
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients.
FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration.
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients.
Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas.
Fatty acid synthase (FASN) as a therapeutic target in breast cancer.
Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab'-Immunoliposomes for Gene Silencing in Breast Cancer Cells.
Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients.
Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma.
Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer.
Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer.
Fatty acid synthase expression in Japanese breast carcinoma patients.
Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients.
Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells.
Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells.
Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice.
Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer.
Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer.
Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer.
Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells.
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.
Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism.
Fatty acid synthase regulates estrogen receptor-? signaling in breast cancer cells.
Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis.
Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.
FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.
Fatty acid synthesis: a potential selective target for antineoplastic therapy.
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.
Hyperglycaemia-induced chemoresistance in breast cancer cells: role of the estrogen receptor.
Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2.
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue.
In Situ Metabolic Characterisation of Breast Cancer and Its Potential Impact on Therapy.
Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis.
Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in patients with Operable TNBC.
Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.
Inhibition of Fatty Acid synthase and sp1 expression by 3,3'-diindolylmethane in human breast cancer cells.
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.
Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere).
Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.
Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase.
Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells.
Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase.
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Mechanism of fatty acid synthase in drug tolerance related to epithelial-mesenchymal transition of breast cancer.
Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols.
MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study.
Mitochondrial dysfunction is responsible for fatty acid synthase inhibition-induced apoptosis in breast cancer cells by PdpaMn.
MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines.
NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition.
Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.
Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity.
Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells.
Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism.
Patuletin induces apoptosis of human breast cancer SK-BR-3 cell line via inhibiting fatty acid synthase gene expression and activity.
PdpaMn inhibits fatty acid synthase-mediated glycolysis by down-regulating PI3K/Akt signaling pathway in breast cancer.
Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells.
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer.
Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases.
Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase.
Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids.
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.
Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway.
RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
Serum fatty acid synthase levels and n-3 fatty acid intake in patients with breast cancer.
Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.
Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects.
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.
Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer.
Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer.
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.
The anti-cancer effects of (-)-epigalocathine-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells.
The anti-cancer effects of (-)-Epigalocathine-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells.
The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.
The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells.
Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.
Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells
Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma.
Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.
Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells.
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.
Virtual screening-based identification of novel fatty acid synthase inhibitor and evaluation of its antiproliferative activity in breast cancer cells.
Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis.
[Expression of epidermal fatty acid-binding protein and fatty acid synthase in infiltrating ductal breast carcinoma.]
[Expression of fatty acid synthase and adipocyte fatty acid-binding protein and the relationship with the clinicopathological characteristics in human infiltrating ductal breast cancer].
[Gene expression of H-FABP and FAS and its clinicopathological significance in breast infiltrating ductal carcinoma]
[Inhibition of triclosan to fatty acid synthase from goose uropygial glands and human breast cancer cells in vitro]
[Transcriptional activities of human fatty acid synthase promoter in breast cancer cells]
Candidiasis
Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis.
Carcinogenesis
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.
Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis.
Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.
Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Dihydroquercetin: More than just an impurity?
Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis.
Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer.
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway.
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study.
Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis.
Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells.
Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma.
LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3?kinase/Akt/fatty acid synthase signaling pathway in vitro.
Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.
Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.
The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells.
The fat side of prostate cancer.
Carcinoma
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
Activation of prolyl hydroxylase-2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF-1?/FASN in ER + breast cancer subtype.
Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines.
Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Different fatty acid metabolism effects of (¿)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer.
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer.
Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.
EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models.
Elevated levels of serum fatty acid synthase in patients with gastric carcinoma.
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes.
Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma.
Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas.
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis.
Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma.
Expression Status of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma.
Expression Staus of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma.
FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1.
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients.
Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma.
Fatty acid synthase and cancer: new application of an old pathway.
Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.
Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma.
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway.
Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma.
Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas.
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Fatty acid synthase expression in cutaneous melanocytic neoplasms.
Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.
Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients.
Fatty acid synthase gene expression in rat mammary carcinoma.
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells.
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Fatty acid synthase: a novel target for antiglioma therapy.
Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals.
High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma.
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.
Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma.
Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas.
Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.
Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway.
Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the ?-catenin/C-myc signaling pathway.
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer.
Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.
Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma.
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer.
Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis.
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma.
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
PHD-2 activation: a novel strategy to control HIF-1? and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype.
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer.
Prognostic Impact of Fatty Acid Synthase Expression in Upper Urinary Tract Urothelial Carcinoma.
Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.
Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids.
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.
Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma.
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas.
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
[Analysis of gene expression of fatty acid synthase in squamous cell carcinoma of the oral cavity by the method of real-time quantitative PCR]
[Cerulenin inhibits growth of human colonic carcinoma in nude mice]
[Effect of down-regulation of fatty acid synthase expression on proliferation, migration and invasion of bladder carcinoma UMUC3 cell lines].
[Fatty acid synthase: a new anti-tumor target.]
Carcinoma in Situ
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.
Carcinoma, Adenoid Cystic
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway.
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Carcinoma, Ductal
Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma.
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
[Expression of fatty acid synthase and its association with HER2 in invasive ductal carcinoma of breast].
Carcinoma, Hepatocellular
4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis.
?-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6.
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish.
Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.
Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins.
Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma.
Effects of retinoic acid and hydrogen peroxide on sterol regulatory element-binding protein-1a activation during adipogenic differentiation of 3T3-L1 cells.
Expression and roles of fatty acid synthase in hepatocellular carcinoma.
Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.
FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line.
Growth Arrest Induced by C75, A Fatty Acid Synthase Inhibitor, was Partially Modulated by p38 MAPK but Not by p53 In Human Hepatocellular Carcinoma.
Human fatty acid synthase: properties and molecular cloning.
Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP.
Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC.
Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the ?-catenin/C-myc signaling pathway.
Insulin increases fatty acid synthase gene transcription in human adipocytes.
Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant phenotype.
Liver X receptor alpha regulates fatty acid synthase expression in chicken.
LXR? limits TGF?-dependent hepatocellular carcinoma associated fibroblast differentiation.
MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
Network analyses identify liver-specific targets for treating liver diseases.
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.
Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met.
Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE.
Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Carcinoma, Intraductal, Noninfiltrating
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
[Expression of fatty acid synthase and its association with HER2 in invasive ductal carcinoma of breast].
Carcinoma, Mucoepidermoid
Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.
Carcinoma, Non-Small-Cell Lung
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.
Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity.
Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis.
Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway.
Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy.
MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.
[Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer]
[Significance of fatty acid synthase expression in non-small cell lung cancer]
Carcinoma, Ovarian Epithelial
Higher Level of Fatty Acid Synthase Enzyme Predicts Lower Rate of Completing Debulking Surgery in Epithelial Ovarian Cancer.
Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis.
Carcinoma, Renal Cell
Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma.
Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma.
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Carcinoma, Squamous Cell
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes.
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells.
Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
[Analysis of gene expression of fatty acid synthase in squamous cell carcinoma of the oral cavity by the method of real-time quantitative PCR]
Carcinoma, Transitional Cell
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer.
Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer.
Cardiovascular Diseases
A thought on the biological activities of black tea.
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Dihydroquercetin: More than just an impurity?
Carotid Stenosis
Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated.
Chagas Disease
A fatty acid synthase gene (FASN3) from the integument tissue of Rhodnius prolixus contributes to cuticle water loss regulation.
Cholangiocarcinoma
Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression.
Classical Swine Fever
Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B.
Colitis
Fatty acid synthase inhibitor C75 ameliorates experimental colitis.
Colitis, Ulcerative
Alterations in intestinal fatty acid metabolism in inflammatory bowel disease.
Overexpression of fatty acid synthase in ulcerative colitis.
Colonic Neoplasms
A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
Body mass index and risk of colorectal cancer according to Fatty Acid synthase expression in the nurses' health study.
Changes in host liver fatty acid synthase in tumour-bearing mice.
Cohort study of fatty acid synthase expression and patient survival in colon cancer.
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.
Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells.
Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.
Interaction of molecular markers and physical activity on mortality in patients with colon cancer.
[An experimental study on cerulenin induced apoptosis of human colonic cancer cells]
Colorectal Neoplasms
A significant role of lipogenic enzymes in colorectal cancer.
Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.
Body mass index and risk of colorectal cancer according to Fatty Acid synthase expression in the nurses' health study.
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Cohort study of fatty acid synthase expression and patient survival in colon cancer.
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.
Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes.
Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway.
Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex.
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway.
High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.
Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study.
In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation.
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration.
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells.
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.
Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.
Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage.
Targeting triglyceride metabolism for colorectal cancer prevention and therapy.
The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells.
The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.
Use of confocal laser endomicroscopy with a fluorescently labeled fatty acid to diagnose colorectal neoplasms.
Coronary Artery Disease
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Coronary Disease
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
COVID-19
Letter to the Editor: Morphoproteomics Confirms the Expression of Fatty Acid Synthase (FAS) in Reactive Alveolar Pneumocytes in a COVID-19 Victim: Biological and Therapeutic Implications.
Cushing Syndrome
Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome.
Cystic Fibrosis
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Dehydration
A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.
Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function.
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
Dengue
Dengue virus infection perturbs lipid homeostasis in infected mosquito cells.
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis.
Involvement of fatty acid synthase in dengue virus infection.
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.
Diabetes Mellitus
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Diabetes Mellitus, Type 2
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes.
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Diabetic Neuropathies
Electrophysiological changes, plasma vascular endothelial growth factor, fatty acid synthase, and adhesion molecules in diabetic neuropathy.
Diabetic Retinopathy
Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy.
Dyslipidemias
A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
Green tea leaf powder prevents dyslipidemia in high-fat diet-fed mice by modulating gut microbiota.
The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice.
Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.
[Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].
Endometrial Hyperplasia
Immunohistochemical investigation of metabolic markers fatty acid synthase (FASN) and glucose transporter 1 (GLUT1) in normal endometrium, endometrial hyperplasia, and endometrial malignancy.
Endometrial Neoplasms
Effects of Fatty Acid Synthase Inhibition by Orlistat on Proliferation of Endometrial Cancer Cell Lines.
Fatty acid synthase expression and clinicopathological findings in endometrial cancer.
Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors.
Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma.
Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer.
Relevance of lipogenesis and AMPK/Akt/mTOR signaling pathway in endometrial cancer.
Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?
Epstein-Barr Virus Infections
Theodore E. Woodward Award: Development of Novel, EBV-Targeted Therapies for EBV-Positive Tumors.
Esophageal Neoplasms
Fatty acid synthase expression and esophageal cancer.
High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy.
Fatty Liver
A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis.
Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver.
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model.
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice.
Chronic everolimus treatment of high-fat diet mice leads to a reduction in obesity but impaired glucose tolerance.
Comparative proteomic study reveals 17?-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.
Comparison of Antiobesity Effects Between Gochujangs Produced Using Different Koji Products and Tabasco Hot Sauce in Rats Fed a High-Fat Diet.
Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles.
Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet.
Effects of Dietary Supplementation with Myo-inositol on Hepatic Expression of Glycolytic and Fructolytic Enzyme Genes in Rats Fed a High-sucrose Diet.
Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model.
Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non?alcoholic fatty liver disease.
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPK?/SREBP1 signaling pathway.
Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers.
Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism.
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Molecular Mechanism of Age-Specific Hepatic Lipid Accumulation in PPARalpha (+/-):LDLR (+/-) Mice, an Obese Mouse Model.
Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice.
Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis.
Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.
Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats.
Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice.
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis.
[11C]acetate PET as a tool for diagnosis of liver steatosis.
[6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis.
Fetal Growth Retardation
Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.
Fibroma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Fibromatosis, Gingival
Proliferation of fibroblasts cultured from normal gingiva and hereditary gingival fibromatosis is dependent on fatty acid synthase activity.
Fibrosarcoma
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.
Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumours overexpress fatty acid synthase.
Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib.
Glioma
Crocetin Extracted from Saffron Shows Antitumor Effects in Models of Human Glioblastoma.
Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment.
Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas.
FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles.
Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells.
Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma.
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis.
Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade.
Granular Cell Tumor
Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
Hepatitis
Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.
Hepatitis B
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Expression of genes involved in lipogenesis is not increased in patients with HCV genotype 3 in human liver.
Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha.
Hepatitis C
Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase.
Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core.
Hepatoblastoma
Regulation of fatty acid synthase expression by cholesterol in human cultured cells.
[Effect of fatty acid synthase gene silencing on lipid metabolism and biological behaviors of human hepatoblastoma HepG2 cells].
Hyperalgesia
Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
Hyperglycemia
Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.
Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice.
Hyperinsulinism
Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism.
Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa Zucker Rats.
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.
In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues.
Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats.
Hyperlipidemias
Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition.
Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes.
Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease.
Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia.
Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice.
Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein.
Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules.
Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet.
The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity.
Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice.
[Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia].
Hyperparathyroidism, Secondary
Immunohistochemical study of fatty acid synthase, Ki67, proliferating cell nuclear antigen, and p53 expression in hyperplastic parathyroids.
Hypersensitivity
Copper deficiency induces hepatic fatty acid synthase gene transcription in rats by increasing the nuclear content of mature sterol regulatory element binding protein 1.
DNase I hypersensitivity sites and nuclear protein binding on the fatty acid synthase gene: identification of an element with properties similar to known glucose-responsive elements.
The inhibitory effect of cerulenin to yeasts is fungicidal.
Hypertension
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism.
Hypertension, Pulmonary
Inhibition of fatty acid synthase is protective in pulmonary hypertension.
Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
Hypertriglyceridemia
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Upregulation of fatty acid synthase gene expression in experimental chronic renal failure.
Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits.
Hypothyroidism
A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations.
A tissue-specific increase in lipogenesis in rat brown adipose tissue in hypothyroidism.
Infections
Adenovirus type 9 enhances differentiation and decreases cytokine release from preadipocytes.
Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
Cellular fatty acid synthase is required for late stages of HIV-1 replication.
Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.
Construction of a cDNA encoding the multifunctional animal fatty acid synthase and expression in Spodoptera frugiperda cells using baculoviral vectors.
Direct-acting antiviral agents against hepatitis C virus and lipid metabolism.
Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection.
Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection.
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.
Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection.
Involvement of fatty acid synthase in dengue virus infection.
Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection.
Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus.
Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.
Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway.
Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis.
Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity.
Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Total synthesis of (-)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods.
West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids.
Inflammatory Bowel Diseases
Fatty acid synthase inhibitor C75 ameliorates experimental colitis.
Insulin Resistance
A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice.
A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis.
Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice.
Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet.
Development of insulin sensitivity in white adipose tissue during the suckling-weaning transition in the rat. Involvement of glucose transport and lipogenesis.
Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-? and leptin, and adipose tissue gene expression.
Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion.
Extracellular Fatty Acid Synthase: a possible surrogate biomarker of insulin resistance.
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis.
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.
MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease.
Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes.
Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice.
Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.
Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis.
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats.
The 1975 type Japanese diet improves the gut microbial flora and inhibits visceral fat accumulation in mice.
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices.
The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue.
[Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia].
[Molecular targets for new drug discovery to treat type 2 diabetes and obesity]
Insulinoma
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
Intellectual Disability
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Ketosis
High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis.
Kidney Failure, Chronic
Upregulation of fatty acid synthase gene expression in experimental chronic renal failure.
Kidney Neoplasms
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Leiomyosarcoma
Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas.
Leukemia
Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway.
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.
[Proliferation inhibition and apoptosis induction of K562 cells by fatty acid synthase inhibitor--cerulenin]
Leukemia, T-Cell
Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line.
Lipid Metabolism Disorders
The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet.
Liposarcoma
Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells.
The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells.
Liver Diseases
Dihydroquercetin: More than just an impurity?
Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Expression of fatty acid synthase in nonalcoholic fatty liver disease.
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non?alcoholic fatty liver disease.
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Network analyses identify liver-specific targets for treating liver diseases.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Neoplasms
Aberrant lipid metabolism as a therapeutic target in liver cancer.
Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.
Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells.
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
Lung Neoplasms
Different fatty acid metabolism effects of (¿)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer.
Fast Nanoliter-Scale Cell Assays Using Droplet Microarray-Mass Spectrometry Imaging.
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer.
FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer.
Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity.
Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis.
Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors.
Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway.
MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase.
Selective inhibition of fatty acid synthase for lung cancer treatment.
[Clinical significance and expression of fatty acid synthase mRNA in lung cancer.]
[Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer]
[Significance of fatty acid synthase expression in non-small cell lung cancer]
Lymphatic Metastasis
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model.
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Lymphoma
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules.
Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy.
The double dealing of cyclin D1.
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Upregulation of fatty acid synthase in MYC and BCL-2 double-expressor lymphoma.
Lymphoma, B-Cell
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.
Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma.
Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBP?/SREBP-1 pathway.
Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure.
Lymphoma, Large B-Cell, Diffuse
FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.
Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma.
Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
Lymphoma, Mantle-Cell
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
The double dealing of cyclin D1.
Lymphoma, T-Cell
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules.
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Malnutrition
Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism.
Melanoma
Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model.
Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish.
Expression of fatty acid synthase (FASN) in oral nevi and melanoma.
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi.
Fatty acid synthase expression in cutaneous melanocytic neoplasms.
Fatty acid synthase expression in melanoma.
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model.
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells.
Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis.
Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines.
Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase.
Primary nasal mucosal melanoma in Brazil: clinicopathologic and immunohistochemical study of 12 patients.
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma.
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.
Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells.
Meningioma
Fatty acid synthase as a novel target for meningioma therapy.
Fatty acid synthase is a predictive marker for aggressiveness in meningiomas.
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma.
Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions.
Mesothelioma
Increased fatty acid synthase is a therapeutic target in mesothelioma.
Metabolic Diseases
Cyclopropaneoctanoic Acid 2-Hexyl Upregulates the Expression of Genes Responsible for Lipid Synthesis and Release in Human Hepatic HepG2 Cells.
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy.
Metabolic Syndrome
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.
Increased activity of the oncogenic fatty acid synthase and the impaired glucose uptake in the metabolic syndrome.
Multiple Myeloma
Erythrocyte membrane fatty acids in multiple myeloma patients.
Fatty acid synthase is a novel therapeutic target in multiple myeloma.
Increased fatty acid synthase as a potential therapeutic target in multiple myeloma.
Retraction. Fatty acid synthase is a novel therapeutic target in multiple myeloma.
[Study on proliferation inhibiting and apoptosis inducing effects of cerulenin on multiple myeloma cells]
Mycoses
The inhibitory effect of cerulenin to yeasts is fungicidal.
Nasopharyngeal Carcinoma
Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma.
Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.
Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.
Neoplasm Metastasis
8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90? downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells.
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells.
Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Data supporting the identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.
Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway.
Fatty acid synthase expression and esophageal cancer.
Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model.
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism.
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.
The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas.
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.
The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesis.
Neoplasms
(S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation.
1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity.
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
A case of metaplastic meningioma with extensive xanthomatous change.
A cohort study of p27 localization in colon cancer, body mass index, and patient survival.
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.
A human fatty acid synthase inhibitor binds ?-ketoacyl reductase in the keto-substrate site.
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers.
A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.
Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.
Adaptive evolution of the human fatty acid synthase gene: support for the cancer selection and fat utilization hypotheses?
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance.
Adipose tissue biomarkers involved in early resolution of type 2 diabetes after bariatric surgery.
Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis.
Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease.
Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase.
An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value.
An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.
Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays.
Androgens and the control of lipid metabolism in human prostate cancer cells.
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
Anti-Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy.
Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines.
Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells.
Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines.
Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK/ACC/CPT1 pathway.
Antitumor effects of curcumin: A lipid perspective.
Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells.
Association between different levels of lipid metabolism?related enzymes and fatty acid synthase in Wilms' tumor.
Associations between obesity and cancer: the role of Fatty Acid synthase.
Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.
Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells.
Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer.
Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions.
Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model.
Bioactive ingredients obtained from Cortex Fraxini impair interactions between FAS and GPI.
Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors.
Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.
Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models.
Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.
Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations.
Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.
Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?
Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression.
Cerulenin-mediated apoptosis is involved in adenine metabolic pathway.
Changes in host liver fatty acid synthase in tumour-bearing mice.
Chapter 3: The shifting balance between CLU forms during tumor progression.
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue.
Characterization of fatty acid synthase in cell lines derived from experimental mammary tumors.
Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells.
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Click-based synthesis and proteomic profiling of lipstatin analogues.
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.
Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study.
Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.
Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice.
Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome.
Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.
Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells.
Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.
Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.
Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells.
De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.
Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics.
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth.
Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.
Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells.
Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice.
Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization.
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75.
Dihydroquercetin: More than just an impurity?
Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet.
Direct visualization of de novo lipogenesis in single living cells.
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.
Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death.
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75.
Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene.
Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells.
Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization.
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-? and leptin, and adipose tissue gene expression.
Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia.
Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas.
Elevated levels of serum fatty acid synthase in patients with gastric carcinoma.
Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention.
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.
Enhanced antitumor activity of epirubicin combined with cerulenin in osteosarcoma.
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells.
Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study.
Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells.
Ethanolic Fraction of Terminalia tomentosa Attenuates Biochemical and Physiological Derangements in Diet Induced Obese Rat Model by Regulating Key Lipid Metabolizing Enzymes and Adipokines.
Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase.
Exploring a role for fatty acid synthase in prostate cancer cell migration.
Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma.
Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker.
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients.
Expression of fatty acid synthase is regulated by PGC?1? and contributes to increased cell proliferation.
Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma.
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.
Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study.
Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness.
Expression Status of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma.
Extranodal Nasal NK/T-Cell Lymphoma: A Rare Oral Presentation and FASN, CD44 and GLUT-1 Expression.
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis.
FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.
FASN inhibition as a potential treatment for endocrine-resistant breast cancer.
FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-?B and SP1.
Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients.
Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas.
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.
Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders.
Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes.
Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target.
Fatty Acid Synthase Activity in Tumor Cells.
Fatty acid synthase and cancer: new application of an old pathway.
Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.
Fatty acid synthase as a novel target for meningioma therapy.
Fatty acid synthase as a potential therapeutic target in cancer.
Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma.
Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer.
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway.
Fatty acid synthase expression and clinicopathological findings in endometrial cancer.
Fatty acid synthase expression and esophageal cancer.
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Fatty acid synthase expression in cutaneous melanocytic neoplasms.
Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.
Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.
Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma.
Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex.
Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells.
Fatty Acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells.
Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine.
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis.
Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules.
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice.
Fatty Acid synthase inhibitors as possible treatment for cancer: patent highlight.
Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.
Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma.
Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis.
Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.
Fatty acid synthase is a predictive marker for aggressiveness in meningiomas.
Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine.
Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane.
Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma.
Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors.
Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.
Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity.
Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism.
Fatty acid synthase regulates estrogen receptor-? signaling in breast cancer cells.
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway.
Fatty acid synthase regulates the pathogenicity of Th17 cells.
Fatty acid synthase: a metabolic oncogene in prostate cancer?
Fatty acid synthase: a novel target for antiglioma therapy.
Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence.
Fatty Acid Synthase: An Emerging Target in Cancer.
Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.
Fatty acid synthesis: a potential selective target for antineoplastic therapy.
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR? Regulation in Hyperlipidemic and Hypertensive Conditions.
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors.
Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production.
G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17?-estradiol in cancer cells and cancer-associated fibroblasts.
Gastrointestinal stromal tumours overexpress fatty acid synthase.
Gene expression analysis by cDNA microarray in oral cancers from two Western populations.
Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy.
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells.
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.
Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis.
Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.
Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation.
Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations.
Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation.
Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals.
Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice.
Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism.
High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy.
High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.
High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells.
High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy.
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.
Higher Level of Fatty Acid Synthase Enzyme Predicts Lower Rate of Completing Debulking Surgery in Epithelial Ovarian Cancer.
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain.
Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis.
Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer.
Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma.
Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas.
Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study.
Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin.
Immunohistochemical investigation of metabolic markers fatty acid synthase (FASN) and glucose transporter 1 (GLUT1) in normal endometrium, endometrial hyperplasia, and endometrial malignancy.
Immunohistochemical study of fatty acid synthase in ovarian neoplasms.
Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors.
Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).
In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines.
In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells.
Increased activity of glycerol 3-phosphate dehydrogenase and other lipogenic enzymes in human bladder cancer.
Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival.
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.
Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients.
Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity.
Increased fatty acid synthase expression in prostate biopsy cores predicts higher Gleason score in radical prostatectomy specimen.
Increased fatty acid synthase is a therapeutic target in mesothelioma.
Increased lipogenesis in cancer cells: new players, novel targets.
Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function.
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors.
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.
Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1?/IGFBP1 pathway.
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.
Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer.
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity.
Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation.
Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo.
Inhibition of fatty acid synthase by polyphenols.
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.
Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells.
Inhibition of fatty acid synthase is protective in pulmonary hypertension.
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma.
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells.
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis.
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Inhibitive effect of zinc ion on fatty acid synthase from chicken liver.
Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.
Inhibitory effects of four plants flavonoids extracts on fatty acid synthase.
Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase.
Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells.
Insulin signaling, inflammation, and lipolysis in subcutaneous adipose tissue of transition dairy cows either overfed energy during the prepartum period or fed a controlled-energy diet.
Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.
iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells.
Kahweol inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.
L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-? Signaling Pathway.
Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression.
Lambda cyhalothrin toxicity induces alterations in lipogenic genes and inflammatory factors in rat liver.
Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells.
Large-scale analysis of HLA peptides presented by HLA-Cw4.
Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase.
Lipid Desaturation: the next step in targeting lipogenesis in cancer?
Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives.
Lipid metabolism in cancer: A systematic review.
Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers.
Lipogenesis in cancer progression (review).
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases.
Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma.
Long-term effects of maternal magnesium restriction on adiposity and insulin resistance in rat pups.
Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells.
Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model.
LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3?kinase/Akt/fatty acid synthase signaling pathway in vitro.
Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPAR?/? Activation in Tumor Myeloid Cells, Leading to Tumor Progression.
Mallory body forming cells express the preneoplastic hepatocyte phenotype.
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells.
MAPK/P53-mediated FASN expression in bone tumors.
Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning.
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors.
Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9).
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
Methods to assess lipid accumulation in cancer cells.
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.
MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma.
Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease.
Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN.
Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma.
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Molecular dynamics simulation of Fe-NO2 At-alpha mangostin as radiopharmaceutical model for detection of fatty acid synthase in cancer.
Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe.
Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.
Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention.
MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines.
Mulberry Leaf Polyphenol Extract Induced Apoptosis Involving Regulation of Adenosine Monophosphate-Activated Protein Kinase/Fatty Acid Synthase in a p53-Negative Hepatocellular Carcinoma Cell.
Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
N-phenylmaleimides affect adipogenesis and present antitumor activity through reduction of FASN expression.
NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition.
Natural fatty acid synthase inhibitors as potent therapeutic agents for cancers: A review.
Nelumbo nucifera Leaves Prevent NMU-Induced Mammary Tumor through Downregulation of Fatty Acid Synthase, Estrogen Receptor-? and Her2 Expression.
New synthetic inhibitors of fatty acid synthase with anticancer activity.
Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis.
NF-{kappa}B mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase.
Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice.
Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells.
Novel antagonists of the thioesterase domain of human fatty acid synthase.
Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness.
Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines.
Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?
Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.
Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade.
Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy.
Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met.
Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells.
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.
Osajin displays potential antiprostate cancer efficacy via impairment of fatty acid synthase and androgen receptor expression.
Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells.
Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis.
Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib.
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis.
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma.
Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism.
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.
Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer.
p63 promotes cell survival through fatty acid synthase.
Peptides from purified soybean beta-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain.
Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.
PHD-2 activation: a novel strategy to control HIF-1? and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype.
Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation.
Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
Platyphylloside Isolated From Betula platyphylla Inhibit Adipocyte Differentiation and Induce Lipolysis Via Regulating Adipokines Including PPAR? in 3T3-L1 Cells.
Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats.
Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.
Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells.
Prognostic Impact of Fatty Acid Synthase Expression in Upper Urinary Tract Urothelial Carcinoma.
Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck.
Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.
Prolyl-isomerase Pin1 Impairs Trastuzumab Sensitivity by Up-regulating Fatty Acid Synthase Expression.
Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein.
Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat.
Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways.
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams.
Reduced expression of FASN through SREBP-1 down-regulation is responsible for hypoxic cell death in HepG2 cells.
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy.
Regulation of lipid metabolism and peroxisome proliferator-activated receptors in rainbow trout adipose tissue by lipolytic and antilipolytic endocrine factors.
Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase.
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.
RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells.
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.
Role of sp transcription factors in the regulation of cancer cell metabolism.
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.
Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions.
S14 protein in breast cancer cells: direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth.
Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
Selective inhibition of fatty acid synthase for lung cancer treatment.
Serum fatty acid synthase as a marker of pancreatic neoplasia.
Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage.
Short communication: Effect of heat stress during the dry period on gene expression in mammary tissue and peripheral blood mononuclear cells.
Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging.
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.
Sodium acetate, propionate, and butyrate reduce fat accumulation in mice via modulating appetite and relevant genes.
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia.
Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway.
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Sugar and fat - that's where it's at: metabolic changes in tumors.
Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats.
Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
Synthesis of novel beta-lactone inhibitors of fatty acid synthase.
Targeting cellular metabolism to improve cancer therapeutics.
Targeting de novo lipogenesis as a novel approach in anti-cancer therapy.
Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression.
Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer.
Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines.
The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells.
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells.
The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.
The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma.
The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model.
The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
The expression of fatty acid metabolism-associated proteins is correlated with the prognosis of meningiomas.
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.
The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis.
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells.
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
The novel inhibitory effect of Pangdahai on fatty acid synthase.
The pathogenesis of prostate cancer: from molecular to metabolic alterations.
The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells.
The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells.
The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesis.
Theodore E. Woodward Award: Development of Novel, EBV-Targeted Therapies for EBV-Positive Tumors.
Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice.
Therapeutic effects of the dipeptidyl peptidase-IV inhibitor, sitagliptin, on non-alcoholic steatohepatitis in FLS-ob/ob male mice.
Thiazolidinediones/PPAR? agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.
Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.
Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase.
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats.
Untargeted mass spectrometry-based metabolomic profiling of pleural effusions: fatty acids as novel cancer biomarkers for malignant pleural effusions.
Up-regulated FASN expression promotes transcoelomic metastasis of ovarian cancer cell through epithelial-mesenchymal transition.
Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer.
Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions.
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
[(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
[An experimental study on cerulenin induced apoptosis of human colonic cancer cells]
[Cerulenin inhibits growth of human colonic carcinoma in nude mice]
[Clinical significance and expression of fatty acid synthase mRNA in lung cancer.]
[Fatty acid synthase and prostate cancer]
[Fatty acid synthase: specific target for cancer therapy]
Neoplasms, Germ Cell and Embryonal
Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors.
Nephrotic Syndrome
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
Neuroblastoma
24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Neurofibrosarcoma
Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.
Nevi and Melanomas
Expression of fatty acid synthase (FASN) in oral nevi and melanoma.
Nevus
Expression of fatty acid synthase (FASN) in oral nevi and melanoma.
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi.
Fatty acid synthase expression in cutaneous melanocytic neoplasms.
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Nevus, Epithelioid and Spindle Cell
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Nevus, Pigmented
Expression of fatty acid synthase (FASN) in oral nevi and melanoma.
Fatty acid synthase expression in cutaneous melanocytic neoplasms.
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Non-alcoholic Fatty Liver Disease
A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats.
A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis.
Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats.
Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.
Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet.
Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Enhanced expression of pro-inflammatory mediators and liver X receptor-regulated lipogenic genes in nonalcoholic fatty liver disease and hepatitits C.
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.
Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Expression of fatty acid synthase in nonalcoholic fatty liver disease.
Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.
Fructose consumption as a risk factor for non-alcoholic fatty liver disease.
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Network analyses identify liver-specific targets for treating liver diseases.
Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Ppar?).
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice.
Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats.
Terminalia paniculata bark extract attenuates nonalcoholic fatty liver via down regulation of fatty acid synthase in high fat diet-fed obese rats.
Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-? and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet.
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Obesity
A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse.
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production.
A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming.
Associations between obesity and cancer: the role of Fatty Acid synthase.
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice.
Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.
Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.
Dietary calcium regulates the risk renal injury in high fat diet induced obese rats by regulating renal lipid metabolism, oxidative stress and inflammation.
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.
Effect of Genetic Variation in the Human Fatty Acid Synthase Gene (FASN) on Obesity and Fat Depot-Specific mRNA Expression.
Endocannabinoid system in cancer cachexia.
Epigenetic Mediators Between Childhood Socioeconomic Disadvantage and Mid-Life Body Mass Index: The New England Family Study.
Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders.
Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation.
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes.
Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells.
Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.
Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma.
Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis.
Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.
Hypolipidemic Activity of Peony Seed Oil Rich in ?-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid ?-Oxidation.
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity.
Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro.
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.
Inhibition of fatty acid synthase by polyphenols.
Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands.
Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.
Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?
Parasitic loranthus from Loranthaceae rather than Viscaceae potently inhibits fatty acid synthase and reduces body weight in mice.
Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats.
Potential predictive biomarkers of obesity in Burmese cats.
Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein.
Regulatory effect of diosgenin on lipogenic genes expression in high-fat diet-induced obesity in mice.
Relationship of polymorphisms within metabolic genes and carcass traits in crossbred beef cattle.
Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity.
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors.
The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices.
The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity.
The novel inhibitory effect of Pangdahai on fatty acid synthase.
[Study on the weight-reducing effect of Acer truncatum leave extract in alimentary obesity rat].
Optic Nerve Diseases
Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.
Osteosarcoma
Acetone immersion enhanced MALDI-MS imaging of small molecule metabolites in biological tissues.
Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models.
Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells.
FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway.
Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis.
Gene expression analysis by cDNA microarray in oral cancers from two Western populations.
Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro.
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.
Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells.
iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells.
microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN.
MicroRNA-320 inhibits osteosarcoma cells proliferation by directly targeting fatty acid synthase.
Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma.
Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase.
Ovarian Neoplasms
Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.
Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.
Fatty acid synthase as a novel target for meningioma therapy.
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.
Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.
Immunohistochemical study of fatty acid synthase in ovarian neoplasms.
Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival.
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells.
Overweight
Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling.
Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans.
Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats.
Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity.
Pancreatic Neoplasms
Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells.
De Novo Lipid Synthesis facilitates Gemcitabine Resistance Through Endoplasmic Reticulum Stress In Pancreatic Cancer.
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.
MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway.
Orlistat Reduces Proliferation and Enhances Apoptosis in Human Pancreatic Cancer Cells (PANC-1).
Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPK? and miR-33a levels to increase apoptosis in Panc-1 and MiaPaCa-2 cells.
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers.
Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage.
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer.
Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract.
Publisher Correction: Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract.
Prostatic Neoplasms
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2.
Analysis of androgen-induced increase in lipid accumulation in prostate cancer cells.
Androgens and the control of lipid metabolism in human prostate cancer cells.
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.
Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis.
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression.
Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study.
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Comparison of the diagnostic value of fatty acid synthase (FASN) with alpha-methylacyl-CoA racemase (AMACR) as prostatic cancer tissue marker.
Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells.
Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics.
Diet-induced alteration of fatty acid synthase in prostate cancer progression.
Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines.
Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization.
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells.
Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [(11) C]acetate PET as a prognostic marker.
Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines.
Exploring a role for fatty acid synthase in prostate cancer cell migration.
Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells.
FABP5 coordinates lipid signaling that promotes prostate cancer metastasis.
FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer.
Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-?B Pathway.
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.
Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.
Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.
Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism.
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.
Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2.
Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer.
Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression.
Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model.
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer.
Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride.
Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells.
Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells.
Large-scale analysis of HLA peptides presented by HLA-Cw4.
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases.
Macropinocytosis confers resistance to therapies targeting cancer anabolism.
Metabolic alterations and targeted therapies in prostate cancer.
Metabolic and molecular regulation of dietary polyunsaturated fatty acids on prostate cancer.
MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells.
Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention.
Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness.
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.
P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth.
Propionic Acid-Based PET Imaging of Prostate Cancer.
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues.
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.
Selective activation of the fatty acid synthesis pathway in human prostate cancer.
Speckle-type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase.
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.
Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells.
Targeting Sp1 transcription factors in prostate cancer therapy.
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells.
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer.
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.
Thiazolidinediones/PPAR? agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.
Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells.
[Androgens and increased lipogenesis in prostate cancer. Cell biologic and clinical perspectives]
[Fatty acid synthase and prostate cancer]
[Immunohistochemical algorithms in prostate diagnostics : What's new?]
Proteinuria
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Psoriasis
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
Pulmonary Arterial Hypertension
The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism.
Pulmonary Disease, Chronic Obstructive
Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan.
Reperfusion Injury
Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation.
Retinitis Pigmentosa
Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.
Retinoblastoma
Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors.
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells.
Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study.
Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness.
Fatty Acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells.
Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations.
The double dealing of cyclin D1.
Rhabdoid Tumor
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines.
Sarcoma
Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas.
Sepsis
Inhibition of lipogenesis reduces inflammation and organ injury in sepsis.
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation.
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.
Shock, Septic
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation.
Spinal Cord Injuries
Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice.
Squamous Cell Carcinoma of Head and Neck
Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines.
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes.
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas.
Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study.
FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1.
Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma.
The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas.
Starvation
Age-dependent hepatic lipogenic enzyme activities in starved-refed rats.
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.
Dietary-induced pre-translational control of rat fatty acid synthase.
Effects of Starvation on Lipid Metabolism and Gluconeogenesis in Yak.
Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast.
Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes.
High carbohydrate diet and starvation regulate lipogenic mRNA in rats in a tissue-specific manner.
Malic enzyme and fatty acid synthase in the uropygial gland and liver of embryonic and neonatal ducklings. Tissue-specific regulation of gene expression.
Regulation of genes for enzymes involved in fatty acid synthesis.
The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats.
The fatty acid synthase gene in avian liver. Two mRNAs are expressed and regulated in parallel by feeding, primarily at the level of transcription.
Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae.
Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect.
Stomach Neoplasms
A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients.
Elevated levels of serum fatty acid synthase in patients with gastric carcinoma.
Expression of Fatty Acid Synthase Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Human Gastric Cancer.
Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis.
FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway.
Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine.
Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.
Identification of diagnostic markers involved in the pathogenesis of gastric cancer through iTRAQ-based quantitative proteomics.
Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer.
Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer.
Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.
Thymoma
A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation.
Thyroid Cancer, Papillary
Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.
Thyroid Neoplasms
Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin.
Triple Negative Breast Neoplasms
(-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer.
Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer.
Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in patients with Operable TNBC.
MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study.
Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b.
Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer.
Trophoblastic Neoplasms
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93.
Tuberculosis
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.
Characterization and site-directed mutagenesis of the putative novel acyl carrier protein Rv0033 and Rv1344 from Mycobacterium tuberculosis.
Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG.
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
Domain analysis of fatty acid synthase protein (NP_217040) from Mycobacterium tuberculosis H37Rv--a bioinformatics study.
Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli.
Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA.
Modeling the Interactions of Herbal Drugs to beta-ketoacyl ACP Synthase of Mycobacterium tuberculosis H37Rv.
Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeast mct1Delta Cells.
Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.
Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins.
Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG.
Purification and characterization of the Mycobacterium tuberculosis FabD2, a novel malonyl-CoA:AcpM transacylase of fatty acid synthase.
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis.
Rv3080c regulates the rate of inhibition of mycobacteria by isoniazid through FabD.
Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.
Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3?Å resolution.
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer.
Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis.
Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer.
Functional genetic variants in apoptosis-associated FAS and FASL genes and risk of bladder cancer in a Turkish population.
Gallic acid inhibits bladder cancer cell proliferation and migration via regulating fatty acid synthase (FAS).
Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.
[Effect of down-regulation of fatty acid synthase expression on proliferation, migration and invasion of bladder carcinoma UMUC3 cell lines].
Usher Syndromes
Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation.
Uterine Cervical Neoplasms
CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression.
Integrated Analysis of a Competing Endogenous RNA Network Revealing a Prognostic Signature for Cervical Cancer.
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase.
Vaccinia
De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection.
Virus Diseases
Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B.
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Identification of fatty acid synthase from the Pacific white shrimp, Litopenaeus vannamei and its specific expression profiles during white spot syndrome virus infection.
Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection.
Involvement of fatty acid synthase in dengue virus infection.
Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection.
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.
Vitamin D Deficiency
Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice.
Wilms Tumor
Association between different levels of lipid metabolism?related enzymes and fatty acid synthase in Wilms' tumor.
Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study.
[acyl-carrier-protein] s-malonyltransferase deficiency
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.