Disease on EC 2.4.1.222 - O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
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Abortion, Spontaneous
Altered ?1,6-GlcNAc and bisecting GlcNAc-branched N-glycan on integrin ?1 are associated with early spontaneous miscarriage in humans.
Adenocarcinoma
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase deficiency
Carbohydrate-deficient glycoprotein syndrome type II. An autosomal recessive N-acetylglucosaminyltransferase II deficiency different from typical hereditary erythroblastic multinuclearity, with a positive acidified-serum lysis test (HEMPAS).
Anemia
Primary defect of congenital dyserythropoietic anemia type II. Failure in glycosylation of erythrocyte lactosaminoglycan proteins caused by lowered N-acetylglucosaminyltransferase II.
Anemia, Dyserythropoietic, Congenital
Primary defect of congenital dyserythropoietic anemia type II. Failure in glycosylation of erythrocyte lactosaminoglycan proteins caused by lowered N-acetylglucosaminyltransferase II.
Breast Neoplasms
B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8+ T cells in pancreatic cancer.
Breast Neoplasms
Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: inhibition of epidermal growth factor-induced dephosphorylation of focal adhesion kinase.
Breast Neoplasms
Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.
Breast Neoplasms
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
Breast Neoplasms
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.
Carcinogenesis
Effects of H-ras and v-sis overexpression on N-acetylglucosaminyltransferase V and metastasis-related phenotypes in human hepatocarcinoma cells.
Carcinoma
Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: inhibition of epidermal growth factor-induced dephosphorylation of focal adhesion kinase.
Carcinoma
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.
Carcinoma, Basal Cell
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.
Carcinoma, Hepatocellular
Distribution of glycosyltransferases among Golgi apparatus subfractions from liver and hepatomas of the rat.
Carcinoma, Hepatocellular
Studies on UDP-N-acetylglucosamine : alpha-mannoside beta-N-acetylglucosaminyltransferase of rat liver and hepatomas.
Carcinoma, Non-Small-Cell Lung
Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion.
Carcinoma, Renal Cell
Changes in N-acetylglucosaminyltransferase III, IV and V in renal cell carcinoma.
Carcinoma, Renal Cell
Nuclear and stromal expression of Manic fringe in renal cell carcinoma.
Choriocarcinoma
Abnormal biantennary sugar chains are expressed in human chorionic gonadotropin produced in the choriocarcinoma cell line, JEG-3.
Colonic Neoplasms
A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer.
Congenital Disorders of Glycosylation
Carbohydrate-deficient glycoprotein syndrome type II. An autosomal recessive N-acetylglucosaminyltransferase II deficiency different from typical hereditary erythroblastic multinuclearity, with a positive acidified-serum lysis test (HEMPAS).
Diphtheria
Biochemical studies of inositol N-acetylglucosaminyltransferase involved in mycothiol biosynthesis in Corynebacterium diphtheria.
Dysostoses
Disruption of the somitic molecular clock causes abnormal vertebral segmentation.
Dysostoses
Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype.
Glioma
Glioma cell fate decisions mediated by Dll1-Jag1-Fringe in Notch1 signaling pathway.
Infertility
A deficiency of lunatic fringe is associated with cystic dilation of the rete testis.
Lung Neoplasms
Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion.
Lung Neoplasms
Manic fringe inhibits tumor growth by suppressing Notch3 degradation in lung cancer.
Lymphoma
A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase.
Malaria
N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria.
Melanoma
Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis.
Melanoma
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.
Melanoma
Melanoma-associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target.
Melanoma
miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization.
Melanoma
[Suppression of lung metastasis of B16 mouse melanoma cells by introduction of N-acetylglucosaminyltransferase III gene]
Multiple Sclerosis
Activity levels of a beta1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients.
Muscular Dystrophies
Biochemical and biophysical changes underlie the mechanisms of basement membrane disruptions in a mouse model of dystroglycanopathy.
Muscular Dystrophies
Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy.
Neoplasm Metastasis
Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis.
Neoplasm Metastasis
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.
Neoplasm Metastasis
Effects of H-ras and v-sis overexpression on N-acetylglucosaminyltransferase V and metastasis-related phenotypes in human hepatocarcinoma cells.
Neoplasm Metastasis
Elevated expression of UDP-N-acetylglucosamine: alphamannoside beta1,6 N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis.
Neoplasm Metastasis
miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization.
Neoplasm Metastasis
Recent progress in the molecular biology of the cloned N-acetylglucosaminyltransferases.
Neoplasm Metastasis
[Suppression of lung metastasis of B16 mouse melanoma cells by introduction of N-acetylglucosaminyltransferase III gene]
Neoplasms
A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro.
Neoplasms
B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8+ T cells in pancreatic cancer.
Neoplasms
Biosynthesis of blood group i-active polylactosaminoglycans. Partial purification and properties of an UDP-GlcNAc:N-acetyllactosaminide beta 1----3-N-acetylglucosaminyltransferase from Novikoff tumor cell ascites fluid.
Neoplasms
Correlated gene expression between beta-1,4-galactosyltransferase V and N-acetylglucosaminyltransferase V in human cancer cell lines.
Neoplasms
Elevated expression of UDP-N-acetylglucosamine: alphamannoside beta1,6 N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis.
Neoplasms
Inflammatory Stress Causes N-Glycan Processing Deficiency in Ocular Autoimmune Disease.
Neoplasms
Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.
Neoplasms
Manic fringe inhibits tumor growth by suppressing Notch3 degradation in lung cancer.
Neoplasms
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.
Neoplasms
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.
Neoplasms
Recent progress in the molecular biology of the cloned N-acetylglucosaminyltransferases.
Neoplasms
The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V.
Neoplasms
Tumor-Suppressive Activity of Lunatic Fringe in Prostate through Differential Modulation of Notch Receptor Activation.
o-fucosylpeptide 3-beta-n-acetylglucosaminyltransferase deficiency
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.
o-fucosylpeptide 3-beta-n-acetylglucosaminyltransferase deficiency
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.
Pancreatic Neoplasms
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Pemphigoid, Bullous
Inflammatory Stress Causes N-Glycan Processing Deficiency in Ocular Autoimmune Disease.
Psoriasis
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.
Tooth Abnormalities
Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.
Vesicular Stomatitis
Growth of enveloped RNA viruses in a line of chinese hamster ovary cells with deficient N-acetylglucosaminyltransferase activity.
Virus Diseases
[Mitochondrial N-acetylglucosaminyl transferase connected with viral infection]
Walker-Warburg Syndrome
Loss-of-function of an N-acetylglucosaminyltransferase, POMGnT1, in muscle-eye-brain disease.
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