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Disease on EC 2.7.1.40 - pyruvate kinase

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DISEASE
TITLE OF PUBLICATION
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5'-nucleotidase deficiency
A basis of the acanthocytosis in inherited and acquired disorders.
[Hemolytic anemias caused by erythrocyte enzyme disorders]
6-phosphofructokinase deficiency
Kinetic properties of mutant enzymes in erythrocyte phosphofructokinase deficiency and erythrocyte pyruvate kinase deficiency.
Acute Kidney Injury
Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury.
Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury.
Adenocarcinoma
Changes in glucose transport activities in mammary adenocarcinoma of dogs.
Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer.
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Identification of Differentiation-Related Proteins in Gastric Adenocarcinoma Tissues by Proteomics.
Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2.
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma.
Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species.
The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus.
[Immunohistologic photometric quantification of pyruvate kinase content of rat tumors]
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Adenocarcinoma of Lung
Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma.
Adenoma
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Enzymatic characteristics of tubular adenomas and carcinomas of the large intestine.
Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors.
Faecal biomarkers do not always identify pre-cancerous lesions in patients who present in primary care with bowel symptoms.
Faecal tumour pyruvate kinase M2: not a good marker for the detection of colorectal adenomas.
Hepatic preneoplasia in hepatitis B virus transgenic mice.
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Reply: Faecal tumour pyruvate kinase M2: not a good marker for detection of colorectal adenomas.
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study.
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Adenoma, Liver Cell
Biochemical microanalysis of pyruvate kinase activity in preneoplastic and neoplastic liver lesions induced in rats by N-nitrosomorpholine.
Unusual histochemical pattern in preneoplastic hepatic foci characterized by hyperactivity of several enzymes.
Adenoma, Oxyphilic
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Adenomatous Polyps
Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps.
adenosine deaminase deficiency
Ultra-performance liquid chromatography-tandem mass spectrometry-based multiplex enzyme assay for six enzymes associated with hereditary hemolytic anemia.
adenylate kinase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Adrenoleukodystrophy
Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.
Alkalosis
[Redox processes in the retina and tunic tissues of the rat eye in experimental alkalosis]
alpha-Thalassemia
Coexistence of alpha-thalassemia and a new pyruvate kinase variant: PK Fukien.
Erythrocyte glucose-6-phosphate dehydrogenase and pyruvate kinase activities in hemoglobin H disease.
Pyruvate kinase deficiency in an alpha-thalassemia family: first case report in Thailand.
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
Altitude Sickness
Effect of chronic altitude hypoxia on hematologic and glycolytic parameters.
Red cell glycolytic intermediates in normal, anaemic and transfused human fetuses.
Alzheimer Disease
Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease.
Amyloid-? peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.
Anaplasmosis
The effect of Anaplasma marginale on the glycolytic pathway in bovine erythrocytes.
Anemia
A deficient pyruvate kinase with an electrophoretically slow-moving component.
A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency.
A new variant of erythrocyte pyruvate kinase - PK "maebashi".
An autopsy case of pyruvate kinase deficiency anemia associated with severe hemochromatosis.
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Coexistence of congenital red cell pyruvate kinase and band 3 deficiency.
Coinheritance of hereditary ellyptocytosis, pyruvate kinase, and glucose-6-phosphate dehidrogenase mutations. A rare anemia diagnostic paradigm.
Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.
Congenital Hemolytic Anemias: Is There a Role for the Immune System?
Detection of G6PD and pyruvate kinase deficiencies in reticulocytosis by reference to erythrocyte creatine.
Enzymic stability of red cells in iron deficiency anaemia. I. Stability of adenosine triphosphate and activity of pyruvate kinase.
Equine infectious anemia. Pyruvate kinase deficiency in the red cells of thoroughbred horses.
Erythrocyte PK deficiency: biochemical characterization of a patient with haemolytic anemia.
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. I. Cell morphology.
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. II. Cell deformability.
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency.
Fetal anaemia due to pyruvate kinase deficiency.
Fragility of abnormal erythrocytes evaluated by response to shear stress.
G6PD/PK ratio: a reliable parameter to identify glucose-6-phosphate dehydrogenase deficiency associated with microcytic anemia in heterozygous subjects.
Haemolytic anaemia in Basenji dogs. 2. Partial deficiency of erythrocyte pyruvate kinase (PK; EC 2.7.1.40) in heterozygous carriers.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Hepatosplenomegaly as the only prenatal finding in a fetus with pyruvate kinase deficiency anemia.
Hepcidin and Anemia: A Tight Relationship.
How I do in front of an hemolytic anemia of unknown etiology?
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
In silico-screening approaches for lead generation: identification of novel allosteric modulators of human-erythrocyte pyruvate kinase.
Increased IgG molecules bound to the surface of red blood cells of patients with sickle cell anemia.
Ineffective erythropoiesis in mutant mice with deficient pyruvate kinase activity.
Inherited erythrocyte pyruvate kinase deficiency: Studies on 15 members of two related families.
Inherited pyruvate kinase deficiency and normal haematologic values in Australian Basenji dogs.
Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.
Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency.
Mechanical membrane properties of human red blood cells and their change due to metabolic disturbance.
Molecular Analyses of Pyruvate Kinase Deficient Turkish Patients from a Single Center.
Molecular and clinical heterogeneity in pyruvate kinase deficiency in India.
Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene.
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Pathogenesis, laboratory diagnosis, and clinical implications of erythrocyte enzyme deficiencies in dogs, cats, and horses.
PK-LR gene mutations in pyruvate kinase deficient Portuguese patients.
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Pyruvate kinase activity of erythrocytes in hereditary non-spherocytic hemolytic anemias.
Pyruvate kinase deficiency anaemia in a Basenji dog.
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn.
Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation.
Pyruvate kinase deficient hemolytic anemia in the Northern Irish population.
Red cell glycolytic intermediates in normal, anaemic and transfused human fetuses.
Red cell pyruvate kinase deficiency in Spain: A study of 15 cases.
Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency.
Reticulocyte-dependent labeling alterations of red cell membrane in pyruvate kinase deficiency anemia.
Severe pyruvate kinase deficiency anemia. A case report.
Spontaneous splenic rupture in primary cytomegalovirus infection.
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.
Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia.
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Surface ultrastructure of pyruvate kinase-deficient erythrocytes in the Basenji dog.
Tanaka KR, Valentine WN, Miwa S. Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia. Blood. 1962;19(3):267-295.
The allosteric regulation of pyruvate kinase.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ?-thalassemia mouse model.
[A family study on pyruvate kinase deficiency anemia]
[Apropos of 3 new types of hemolytic anemia in children. Infantile pyknocytosis. Familial hemolytic anemia with erythrocytic inclusions and pigmenturia. Anemia caused by a deficiency of pyruvate kinase.]
[Clinical studies on hereditary nonspherocytic anemia with erythrocyte pyruvate kinase deficiency]
[Diagnosis of pyruvate kinase deficiency]
[Erythrocyte pyruvate kinase in healthy subjects and in nonspherocytic hemolytic pyruvate-kinase deficiency anemia]
[Erythrocytic pyruvate kinase. II. Enzymatic heterogeneity of deficiencies. Studies concerning 28 cases with congenital hemolytic anemia]
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
[Hemolytic anemias with pyruvate kinase deficiency]
[HEREDITARY HEMOLYTIC ANEMIAS WITH PYRUVATE KINASE DEFICIENCY.]
[On indications of spleen extirpation in nonspherocytic hemolytic anemias. Favorable success in pyruvate kinase deficiency]
[Prenatal diagnosis of homozygous pyruvate kinase deficiency]
[Problems in hemolytic anemias with insufficient pyruvate kinase. II. Identification of mutants of pyruvate kinase]
[Problems in hemolytic anemias with pyruvate kinase deficiency. I. Clinical and hematologic picture in 4 patients]
[Problems of erythrocyte metabolism in anemias with pyruvate kinase deficiency]
[Pyruvate kinase activity of erythrocytes in hereditary non-spherocytic hemolytic anemias]
[Pyruvate kinase deficiency in the newborn infant]
[Significance of kinetic abnormalities of erythrocyte pyruvate kinase in congenital deficiencies]
[Studies on erythrocyte metabolism in various hemolytic anemias: with special reference to pyruvate kinase deficiency]
Anemia, Aplastic
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia.
[Relative deficiency of glutathione reductase and or pyruvate kinase in erythrocytes in aplastic anemia and acute leukemia]
Anemia, Diamond-Blackfan
Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia.
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Anemia, Dyserythropoietic, Congenital
Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.
Congenital Hemolytic Anemias: Is There a Role for the Immune System?
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Hepcidin and Anemia: A Tight Relationship.
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Anemia, Hemolytic
A CASE OF CONGENITAL ATYPICAL HAEMOLYTIC ANAEMIA WITH PYRUVATE KINASE DEFICIENCY.
A case of haemolytic anaemia due to pyruvate kinase deficiency.
A case of hereditary spherocytosis misdiagnosed as pyruvate kinase deficient hemolytic anemia.
A case of severe pyruvate kinase deficiency in a primigravida: successful outcome.
A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report.
A kindred with red cell pyruvate kinase deficiency.
A New Variant of PKLR Gene Associated With Mild Hemolysis may be Responsible for the Misdiagnosis in Pyruvate Kinase Deficiency.
A Novel and a Previously Described Compound Heterozygous PKLR Gene Mutations Causing Pyruvate Kinase Deficiency in a Chinese Child.
A pyruvate kinase variant with an increased affinity for phosphoenolpyruvate in an individual with congenital non-spherocytic haemolytic anaemia.
A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report.
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency.
Acquired pyruvate kinase deficiency.
Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency.
Adoptive immunotherapy to increase the level of donor hematopoietic chimerism after nonmyeloablative marrow transplantation for severe canine hereditary hemolytic anemia.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia.
Alu element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients.
AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency.
An isozyme of erythrocyte pyruvate kinase (PK-Los Angeles) with impaired kinetics corrected by fructose-1, 6-diphosphate.
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency.
Atypical pyruvate kinase in a family with spherocytic haemolytic anaemia.
Atypical pyruvate kinase in a patient with haemolytic anaemia.
Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat.
Biochemical and molecular characterization of variant pyruvate kinase enzymes and genes from three patients with red blood cell pyruvate kinase deficiency.
Biochemical characterization of four new erythrocyte pyruvate kinase variants.
Biochemical characterization of three mutant isozymes of erythrocyte pyruvate kinase: PK-"Gainesville," PK-"San Juan," and PK-"Cape Canaveral".
Biphasic reaction kinetics in an anomalous isozyme of erythrocyte pyruvate kinase.
Calculation of surface area and volume of human erythrocytes from scanning electron micrographs.
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell disease.
Chronic haemolytic anaemia in two patients heterozygous for erythrocyte pyruvate kinase deficiency. Electrofocusing and immunological studies of erythrocyte and liver pyruvate kinase.
Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency.
Comorbidities and complications in adults with pyruvate kinase deficiency.
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. I. Erythrokinetic patterns.
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. II. Enzymatic studies.
Consensus document for the diagnosis and treatment of pyruvate kinase deficiency.
Cord blood transplantation in a young child with pyruvate kinase deficiency.
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
Delayed onset of hemolytic anemia in CBA-Pk-1slc/Pk-1slc mice with a point mutation of the gene encoding red blood cell type pyruvate kinase.
Determination of erythrocyte pyruvate kinase deficiency in Basenjis with chronic hemolytic anemia.
Development of an Automated Enzymatic Method to Quantify Pyruvate Kinase in Red Blood Cells.
Diagnosis of pyruvate kinase deficiency in a transfusion-dependent patient with severe hemolytic anemia.
Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency.
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.
Effect of riboflavin treatment on human red cell pyruvate kinase deficiency.
Eight novel mutations and consequences on mRNA and protein level in pyruvate kinase-deficient patients with nonspherocytic hemolytic anemia.
Elevated pyruvate kinase activity in patients with hemolytic anemia due to red cell pyruvate kinase "deficiency".
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. I. Cell morphology.
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers?
Erythrocyte pyruvate kinase deficiency mutation identified in multiple breeds of domestic cats.
ERYTHROCYTE PYRUVATE KINASE DEFICIENCY RESULTING IN CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Erythrocyte pyruvate kinase deficiency: 2015 status report.
Erythrocyte pyruvate kinase- and glucose phosphate isomerase deficiency: perturbation of glycolysis by structural defects and functional alterations of defective enzymes and its relation to the clinical severity of chronic hemolytic anemia.
Erythrocytic pyruvate kinase deficiency and hemolytic anemia inherited as a dominant trait.
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs.
Erythropoiesis: Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.
Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population.
Ex vivo analysis of aberrant splicing induced by two donor site mutations in PKLR of a patient with severe pyruvate kinase deficiency.
Extreme deficiency of L-type pyruvate kinase with moderate clinical expression.
Familial haemolytic anaemia due to pyruvate kinase deficiency.
Familial hemolytic anemia resulting from an abnormal red blood cell pyruvate kinase.
Fifteen novel mutations in PKLR associated with pyruvate kinase (PK) deficiency: structural implications of amino acid substitutions in PK.
First reported case of prenatal diagnosis for pyruvate kinase deficiency in a Chinese family.
Five unknown mutations in the LR pyruvate kinase gene associated with severe hereditary nonspherocytic haemolytic anaemia in France.
Frame shift mutation, exon skipping, and a two-codon deletion caused by splice site mutations account for pyruvate kinase deficiency.
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Genetic test for pyruvate kinase deficiency of Basenjis.
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt.
Haematological parameters and altered erythrocyte metabolism in anaemic dogs.
Haemolytic anaemia due to pyruvate kinase deficiency.
Haemolytic anaemia in Basenji dogs. 2. Partial deficiency of erythrocyte pyruvate kinase (PK; EC 2.7.1.40) in heterozygous carriers.
Haemolytic anaemia with hereditary pyruvate kinase instability developing acute leukaemia.
Health-Related Quality of Life and Fatigue in Children and Adults with Pyruvate Kinase Deficiency.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Hemolytic anemia and pyruvate kinase deficiency in pregnancy.
Hemolytic anemia due to pyruvate kinase deficiency: characterization of the enzymatic activity from eight patients.
Hemolytic anemia in pregnancy associated with erythrocyte pyruvate kinase deficiency.
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma.
Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: A biochemical, genetic and clinical overview.
Hereditary hemolytic anemia caused by diverse point mutations of pyruvate kinase gene found in Japan and Hong Kong.
Hereditary nonspherocytic hemolytic anemia due to pyruvate kinase deficiency: a prevalence study in Quebec (Canada).
Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases.
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
Homozygous pyruvate kinase deficiency in Hong Kong ethnic minorities.
How we manage patients with pyruvate kinase deficiency.
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia.
Identification and in silico characterization of a novel PKLR genotype in a Turkish newborn.
Identification of a novel promoter mutation in the human pyruvate kinase (PK) LR gene of a patient with severe haemolytic anaemia.
Identification of an erythrocyte pyruvate kinase variant in a family from Latium with non-spherocytic congenital haemolytic anaemia.
Impaired erythrocyte phosphoribosylpyrophosphate formation in hemolytic anemia due to pyruvate kinase deficiency.
Improving the laboratory diagnosis of pyruvate kinase deficiency.
In silico-screening approaches for lead generation: identification of novel allosteric modulators of human-erythrocyte pyruvate kinase.
In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.
Inherited pyruvate kinase deficiency and normal haematologic values in Australian Basenji dogs.
Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Laboratory studies of erythrocytic pyruvate kinase deficiency. Pathogenesis of the hemolysis.
Life-threatening nonspherocytic hemolytic anemia in a patient with a null mutation in the PKLR gene and no compensatory PKM gene expression.
Low substrate affinity of pyruvate kinase variant (PK Sapporo) caused by a single amino acid substitution (426 Arg-->Gln) associated with hereditary hemolytic anemia.
Malaria: looking for selection signatures in the human PKLR gene region.
Management of pyruvate kinase deficiency in children and adults.
Membrane-localized pyruvate kinase of red blood cells in hemolytic anemia associated with pyruvate kinase deficiency.
Mining for allosteric information: Natural mutations and positional sequence conservation in pyruvate kinase.
Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia.
Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients. Red Cell Pathology Group of the Spanish Society of Haematology (AEHH).
Molecular characterization of the PK-LR gene in sixteen pyruvate kinase-deficient patients.
Molecular heterogeneity of pyruvate kinase deficiency.
Molecular modelling of human red blood cell pyruvate kinase: structural implications of a novel G1091 to a mutation causing severe nonspherocytic hemolytic anemia.
Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia.
Mutations in pyruvate kinase.
Mutations in the R-type pyruvate kinase gene and altered enzyme kinetic properties in patients with hemolytic anemia due to pyruvate kinase deficiency.
Nonspherocytic haemolytic anaemia and severe jaundice in a newborn with partial pyruvate kinase deficiency.
Novel mutations and structural implications in R-type pyruvate kinase-deficient patients from Southern Italy.
Novel mutations associated with pyruvate kinase deficiency in Brazil.
Patient with pyruvate kinase deficiency developed acute myelogenous leukemia.
Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
PK Mondor: prenatal diagnosis of a frameshift mutation in the LR pyruvate kinase gene associated with severe hereditary non-spherocytic haemolytic anaemia.
PK-LR gene mutations in pyruvate kinase deficient Portuguese patients.
Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase deficiency.
Prevalence of erythrocyte pyruvate kinase deficiency and normal values of enzyme in a Turkish population.
Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia.
Pyruvate kinase deficiency anaemia in a Basenji dog.
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Pyruvate kinase deficiency causing hemolytic anemia with secondary hemochromatosis in a Cairn terrier.
Pyruvate kinase deficiency complicating pregnancy.
Pyruvate kinase deficiency hemolytic anemia: enzymatic characterization studies in twelve patients.
Pyruvate kinase deficiency hemolytic anemia: two successful pregnancy outcomes.
Pyruvate kinase deficiency in children.
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.
Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation.
Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Pyruvate kinase deficiency: characterization of two new genetic variants.
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants.
Pyruvate kinase deficiency: the genotype-phenotype association.
PYRUVATE KINASE DEFICIENT HEMOLYTIC ANEMIA IN AN AMISH ISOLATE.
Pyruvate kinase deficient hemolytic anemia in the Northern Irish population.
Pyruvate kinase Greensboro. A four-generation study of a high K0.5s (phosphoenolpyruvate) variant.
Pyruvate kinase isozyme (PK-Greenville) with defective allosteric activation by fructose-1,6-diphosphate: the role of F-1,6-P modulation in normal erythrocyte metabolism.
Quinine protects pyruvate-kinase deficient red cells from dehydration.
Red blood cell age, pyruvate kinase activity, and insulin receptors. Evidence that monocytes and RBCs may behave differently.
Red Blood Cell Enzyme Disorders.
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Red blood cell PK deficiency: An update of PK-LR gene mutation database.
Red cell pyruvate kinase deficiency in Southern Sardinia.
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene.
Red cell pyruvate kinase deficiency: adverse effect of oral contraceptives.
Red cell pyruvate kinase deficiency: from genetics to clinical manifestations.
Red cell pyruvate kinase deficiency: molecular and clinical aspects.
Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme.
Residual pyruvate kinase activity in PKLR deficient erythroid precursors of a patient suffering from severe haemolytic anaemia.
Retrovirus-mediated gene transfer of human pyruvate kinase (PK) cDNA into murine hematopoietic cells: implications for gene therapy of human PK deficiency.
RLS with PLMS in a child with hemolytic anemia caused by pyruvate kinase deficiency.
Roentgenographic manifestations of pyruvate kinase deficiency hemolytic anemia.
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
Sequestration and destruction of reticulocyte in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia.
Severe canine hereditary hemolytic anemia treated by nonmyeloablative marrow transplantation.
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Severe hemolytic anemia in a Vietnamese family, associated with novel mutations in the gene encoding for pyruvate kinase.
Severe hereditary haemolytic anaemica in dogs treated by marrow trasplantation.
Severe pyruvate kinase deficiency anemia. A case report.
Simultaneous inheritance of mutant isoenzymes of erythrocyte pyruvate kinase associated with chronic haemolytic anaemia.
Single port robotic splenectomy for pyruvate kinase deficiency in a five-year-old patient, a case report of a surgical first.
Six previously undescribed pyruvate kinase mutations causing enzyme deficiency.
Spectrum of novel mutations in the human PKLR gene in pyruvate kinase-deficient Indian patients with heterogeneous clinical phenotypes.
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.
Study of the molecular defects in pyruvate kinase deficient patients affected by nonspherocytic hemolytic anemia.
Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia.
Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency.
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Tanaka KR, Valentine WN, Miwa S. Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia. Blood. 1962;19(3):267-295.
The burden of disease in pyruvate kinase deficiency: Patients' perception of the impact on health-related quality of life.
The clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study.
The influence of magnesium ions on pyruvate kinase-deficient red blood cells.
The molecular basis of canine pyruvate kinase deficiency.
The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
The variable manifestations of disease in pyruvate kinase deficiency and their management.
Three cases of hemolytic anemia with erythrocyte pyruvate kinase deficiency in Alberta.
Three pyruvate kinase variants with increased affinity for PEP.
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency.
Two homozygous cases of erythrocyte pyruvate kinase (PK) deficiency in Japan: PK Sendai and PK Shinshu.
Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia.
[A case of congenital non-spherocytic hemolytic anemia caused by enzyme deficiency in pyruvate kinase]
[A case of nonspherocytic hemolytic anemia caused by deficient activity of erythrocyte pyruvate kinase]
[Anomalies of glycolysis during hemolytic anemia due to deficiency of pyruvate kinase in the erythrocytes]
[Apropos of 3 new types of hemolytic anemia in children. Infantile pyknocytosis. Familial hemolytic anemia with erythrocytic inclusions and pigmenturia. Anemia caused by a deficiency of pyruvate kinase.]
[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]
[Congenital non spherocytic hemolytic anemia caused by pyruvate kinase abnormalities]
[Congenital nonspherocytic hemolytic anemia with deficiency of erythrocytic pyruvate kinase]
[Constitutional hemolytic anemia due to pyruvate kinase deficiency. Study of 2 families]
[Defects in erythrocyte glycolysis enzymes as the cause of nonspherocytic hemolytic anemia]
[Deficiency of pyruvate kinase in erythrocytes: biochemical studies. Preliminary communication]
[Efficacy of splenectomy in 2 cases of hemolytic anemia caused by pyruvate kinase deficiency]
[Ektacytometric determination of the deformability of red blood cells in hemolytic anemia with pyruvate kinase deficiency]
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in a heterozygote]
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in single and double heterozygotes]
[Erythrocytic pyruvate kinase deficiency accompanied by a severe neonatal hemolytic anemia. Family study and biochemical characterization of the enzyme]
[Erythrocytic pyruvate kinase. II. Enzymatic heterogeneity of deficiencies. Studies concerning 28 cases with congenital hemolytic anemia]
[Familial chronic jaundice caused by nonspherocytic hemolytic anemia, with increase of erythrocyte pyruvate kinase]
[From gene to disease; hereditary non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
[Glucocorticoid-induced effect of erythropoietin in haemolytic anaemia with uraemia and red cell enzyme deficiency (author's transl)]
[Haemolytic anaemia an leg ulcers due to pyruvate kinase deficiency. report of the second venezuelan family (author's transl)]
[Haemolytic anaemia due to hereditary defect of erythrocyte pyruvate kinase. Clinical, familial, and biological study of ten cases (author's transl)]
[Hemolytic anemia caused by pyruvate kinase deficiency and pregnancy]
[Hereditary haemolytic anaemia due to pyruvate kinase deficiency. Prognosis of neonatal forms (author's transl)]
[Inherited hemolytic anemia due to pyruvate kinase deficiency: II. Density-layer centrifugation of erythrocytes (author's transl)]
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
[Metabolic studies in a family with 3 cases of congenital non-spherocytic hemolytic anemia with a pyruvate kinase deficiency]
[Molecular study of red cell pyruvate kinase deficiency in 15 patients with chronic hemolytic anemia. Group of Erythropathology of Hematology and hemotherapy Association of Spain (HHAS)]
[Non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
[Nonspherocytic haemolytic anaemia due to inborn pyruvate kinase disorder (variant PK--type 1) in a Slovak family (author's transl)]
[Nonspherocytic hemolytic anemia in pyruvate kinase deficiency]
[Physico-chemical and kinetic properties of pyruvate kinase in erythrocytes in enzymopathic hemolytic anemia]
[Pyruvate kinase deficiency ass3ciated with nonspherocytic hemolytic anemia. Biochemical hematological study of 3 cases]
[PYRUVATE KINASE DEFICIENCY HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA. REPORT OF TWO CASES IN A JAPANESE FAMILY AND REVIEW OF LITERATURE.]
[Pyruvate kinase deficiency in hereditary, non-spherocytic hemolytic anemia]
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
[Splenectomized pyruvate kinase deficiency hemolytic anemia with positive Coombs' test: report of a case with family study (author's transl)]
[The clinical and laboratory characteristics of congenital pyruvate kinase deficiency].
[Vascular complications in a case of hemolytic anemia due to pyruvate kinase deficiency]
Anemia, Hemolytic, Autoimmune
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
Serum ferritin in patients with various haemolytic disorders.
[The modified "pink test" in the diagnosis of hereditary spherocytosis]
Anemia, Hemolytic, Congenital
A case of hereditary spherocytosis misdiagnosed as pyruvate kinase deficient hemolytic anemia.
A Case With Pyruvate Kinase Deficiency Remarkably Sensitive to Heat.
A family case of pyruvate kinase variant, PK 'Nichinan'.
A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency.
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Case report: pyruvate kinase deficiency.
cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia.
Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency.
Erythrocyte pyruvate kinase deficiency in the Ohio Amish: origin and characterization of the mutant enzyme.
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Functionally abnormal pyruvate kinase in congenital hemolytic anemia.
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
Hereditary hemolytic anemia caused by diverse point mutations of pyruvate kinase gene found in Japan and Hong Kong.
Identical point mutations of the R-type pyruvate kinase (PK) cDNA found in unrelated PK variants associated with hereditary hemolytic anemia.
Increased expression of a novel leukocytic factor in patients with hemolytic anemia.
Intra-erythrocytary enzymes before and after splenectomy.
Low substrate affinity of pyruvate kinase variant (PK Sapporo) caused by a single amino acid substitution (426 Arg-->Gln) associated with hereditary hemolytic anemia.
Molecular aspects of erythroenzymopathies associated with hereditary hemolytic anemia.
Molecular basis of erythroenzymopathies associated with hereditary hemolytic anemia: tabulation of mutant enzymes.
Molecular characterization of PK-LR gene in pyruvate kinase-deficient Italian patients.
Mutations in the pyruvate kinase L gene in patients with hereditary hemolytic anemia.
Prevalence of erythrocyte pyruvate kinase deficiency and normal values of enzyme in a Turkish population.
Pyruvate kinase "Göttingen 1,2": congenital hemolytic anemia, evidence of double heterozygosity, and lack of enzyme cooperativity.
Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-line de novo mutation.
Red cell enzymopathies as a model of inborn errors of metabolism.
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
Six novel variants in the PKLR gene associated with pyruvate kinase deficiency in Argentinian patients.
[Congenital hemolytic anemia caused by pyruvate kinase variants (PK 'Kasumi')]
[Erythrocytic pyruvate kinase. II. Enzymatic heterogeneity of deficiencies. Studies concerning 28 cases with congenital hemolytic anemia]
[Hereditary hemolytic anemia due to functionally abnormal pyruvate kinase. Report of a case (author's transl)]
[HEREDITARY HEMOLYTIC ANEMIAS WITH PYRUVATE KINASE DEFICIENCY.]
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
[Nonspherocytic congenital hemolytic anemia induced by a pyruvate kinase deficiency. Presentation of a clinical case]
[Pathophysiology and laboratory tests of hemolytic anemia: with special reference to erythroenzymopathies]
[Pyruvate kinase deficiency hereditary hemolytic anemia (author's transl)]
Anemia, Hemolytic, Congenital Nonspherocytic
ERYTHROCYTE PYRUVATE KINASE DEFICIENCY RESULTING IN CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Management of pyruvate kinase deficiency in children and adults.
The influence of magnesium ions on pyruvate kinase-deficient red blood cells.
[Congenital nonspherocytic hemolytic anemia with deficiency of erythrocytic pyruvate kinase]
Anemia, Iron-Deficiency
Enzymic stability of red cells in iron deficiency anaemia. I. Stability of adenosine triphosphate and activity of pyruvate kinase.
Spontaneous splenic rupture in primary cytomegalovirus infection.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Anemia, Macrocytic
Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Anemia, Neonatal
[Prenatal diagnosis of homozygous pyruvate kinase deficiency]
Anemia, Pernicious
[The importance of determination of ferritin levels in erythrocytes]
Anemia, Refractory
Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases.
[Enzyme deficiencies of blood cells in bone marrow insufficiency (author's transl]
Anemia, Sickle Cell
A new sickle cell disease phenotype associating Hb S trait, severe pyruvate kinase deficiency (PK Conakry), and an alpha2 globin gene variant (Hb Conakry).
Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell disease.
Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy.
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
How I do in front of an hemolytic anemia of unknown etiology?
Increased IgG molecules bound to the surface of red blood cells of patients with sickle cell anemia.
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Red blood cell disorders in Rwandese neonates: screening for sickle cell disease and glucose-6-phosphate dehydrogenase deficiency.
Relationship of density distribution and pyruvate kinase electrophoretic pattern of erythrocytes in sickle cell diseases and other disorders.
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters.
Sickle cell disease in a carrier with pyruvate kinase deficiency.
Anemia, Sideroblastic
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Hepcidin and Anemia: A Tight Relationship.
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Targeted next generation sequencing for the diagnosis of patients with rare congenital anemias.
Angina Pectoris
A kindred with red cell pyruvate kinase deficiency.
Arthritis, Psoriatic
Granulocyte pyruvate kinase in psoriasis vulgaris and psoriasis arthropathica.
Arthritis, Rheumatoid
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Asthma
Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma.
Astrocytoma
Cellular expression of K-type pyruvate kinase in normal and neoplastic human tissues.
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism.
Study of pyruvate kinase activity in human astrocytomas - Alanine-inhibition test revisted.
Ataxia
The double dealing of cyclin D1.
Atherosclerosis
T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2.
Autoimmune Diseases
Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders.
Babesiosis
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice.
Bacterial Infections
Caffeine supplementation in diet mitigates Aeromonas hydrophila-induced impairment of the gill phosphotransfer network in grass carp Ctenopharyngodon idella.
Involvement of the phosphoryl transfer network on cardiac energetic metabolism during Staphylococcus aureus infection and its association to disease pathophysiology.
Ribosome-Amplified Metabolism, RAMBO, Measured by NMR Spectroscopy.
Barrett Esophagus
Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia.
beta-Thalassemia
31P NMR spectroscopy of erythrocytes in congenital hemolytic anemias: detection of heterogeneous erythrocyte populations and quantification of intracellular 2,3-diphosphoglycerate.
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families.
[Pyruvate kinase deficiency in a patient with beta-thalassemia]
[The importance of determination of ferritin levels in erythrocytes]
Bile Duct Neoplasms
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Biliary Tract Neoplasms
Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer.
Bloom Syndrome
Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme.
Dominant negative effect of novel mutations in pyruvate kinase-M2.
Dominant negative mutations affect oligomerisation of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy.
Brain Diseases
Correction to: Clinical approach to neurodegenerative disorders in childhood: an updated overview.
Brain Injuries
Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.
Brain Neoplasms
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
The pyruvate kinase isoenzyme shift in human gliomas: a potential marker in the treatment of gliomas.
[Pyruvate kinase as a marker of human brain tumors]
Breast Diseases
Enzyme Kinetic Assay to Measure the Activity of Tumor M2 Pyruvate Kinase in Breast Cancer Patients.
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Breast Neoplasms
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Comparison of pyruvate kinase variants from breast tumor and normal breast.
Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2.
Effect of pyruvate kinase M2-regulating aerobic glycolysis on chemotherapy resistance of estrogen receptor-positive breast cancer.
Enzyme Kinetic Assay to Measure the Activity of Tumor M2 Pyruvate Kinase in Breast Cancer Patients.
Expression and clinical significance of pyruvate kinase M2 in breast cancer: A protocol for meta-analysis and bioinformatics validation analysis.
Expression of multimolecular forms of pyruvate kinase in normal, benign, and malignant human breast tissue.
Glycolytic enzyme activities in breast cancer metastases.
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPAR? in breast cancer pathophysiology.
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer.
Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.
Isozyme patterns of normal, benign, and malignant human breast tissues.
Kisspeptin 10 inhibits the Warburg effect in breast cancer through the Smad signaling pathway: both in vitro and in vivo.
Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression.
Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2.
Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.
NADH-Linked Metabolic Plasticity of MCF-7 Breast Cancer Cells Surviving in a Nutrient-Deprived Microenvironment.
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma.
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells.
PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
PKM2 promotes stemness of breast cancer cell by through Wnt/?-catenin pathway.
Plasma levels of HER-2/neu, tumor type M2 pyruvate kinase and its tyrosine-phosphorylated metabolite in advanced breast cancer.
Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer: A meta-analysis.
Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells.
Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells.
The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer.
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.
Tumor M2 pyruvate kinase--determination in breast cancer patients receiving trastuzumab therapy.
Tumor type M2 pyruvate kinase expression in advanced breast cancer.
Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect.
[Biochemical behavior of pyruvate kinase, LDH, isocitrate dehydrogenase and malate dehydrogenase in breast carcinomas]
Bronchitis
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
Burkitt Lymphoma
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Carcinogenesis
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia.
Aspirin shares a short-term effect, inhibition of pyruvate kinase activity with tumor-promoting agents, but fails to promote rat liver carcinogenesis.
Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment.
Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma.
Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter.
Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Establishment of renal proximal tubule cell lines by targeted oncogenesis in transgenic mice using the L-pyruvate kinase-SV40 (T) antigen hybrid gene.
Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
Isoform switch of pyruvate kinase m1 indeed occurs but not to pyruvate kinase m2 in human tumorigenesis.
Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells.
Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma.
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-?B pathway in HNSCC.
LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2.
Metabolic changes in cancer: beyond the Warburg effect.
miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Modifications of the expression of liver-specific and non-specific messenger RNAs during azo-dye hepatocarcinogenesis.
Modulation of PKM activity affects the differentiation of TH17 cells.
Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis.
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression.
Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1? Secretion.
PKM2 regulates Gli1 expression in hepatocellular carcinoma.
PKM2-c-Myc-Survivin Cascade Regulates the Cell Proliferation, Migration, and Tamoxifen Resistance in Breast Cancer.
Prolactin Inhibits Activity of Pyruvate Kinase M2 to Stimulate Cell Proliferation.
Protein kinase function of pyruvate kinase M2 and cancer.
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis.
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis.
SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma.
Significant association of PKM2 and NQO1 proteins with poor prognosis in breast cancer.
Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes.
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer.
Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format.
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
[Changes in the isoenzymatic makeup of pyruvate kinase in hepatic carcinogenesis]
[Pyruvate kinase isozymes in the liver during azo dye carcinogenesis]
Carcinoma
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Biochemical microanalysis of pyruvate kinase activity in preneoplastic and neoplastic liver lesions induced in rats by N-nitrosomorpholine.
Carbohydrate metabolism in human renal clear cell carcinomas.
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK.
Decreased pyruvate kinase M2 activity linked to cisplatin resistance in human gastric carcinoma cell lines.
Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal canhcer.
Enzymatic characteristics of tubular adenomas and carcinomas of the large intestine.
Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma.
Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas.
Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Identification of potential canine mammary tumour cell biomarkers using proteomic approach: Differences in protein profiles among tumour and normal mammary epithelial cells by two-dimensional electrophoresis-based mass spectrometry.
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma.
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh's ESCC and promotes proliferation and migration of ESCC cells.
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.
Plasma?derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
Pyruvate kinase isoenzymes in altered foci and carcinoma of rat liver.
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.
Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
Pyruvate kinase type tumor M2 in urological malignancies.
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas.
STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/?-catenin pathway in cervical carcinoma cells.
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
The Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 for Biliary Tract Carcinoma. A Systematic Review and Meta-Analysis.
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
[Hybrid forms of the enzyme pyruvate kinase in human carcinomas]
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
[Relationship between gastric carcinoma and enzyme spectrum activity in gastric mucosal intestinal metaplasia]
[Renal cell carcinoma. Immunohistological study to the expression of the inactive form of the pyruvate kinase]
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
[Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
Carcinoma, Ductal
[Hybrid forms of the enzyme pyruvate kinase in human carcinomas]
Carcinoma, Ehrlich Tumor
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Effects of L-alanine and fructose (1,6-diphosphate) on pyruvate kinase from ehrlich ascites tumour cells.
Extraction of a factor from Ehrlich ascites tumor cells that increases the activity of the fetal isozyme of pyruvate kinase in mouse liver.
Interconversion phenomena between two kinetic forms of class a pyruvate kinase from Ehrlich ascites tumor cells.
Interconvertible forms of class A pyruvate kinase from Ehrlich ascites tumour cells.
Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle.
Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers.
Stimulation of tumor-cell respiration by inhibitors of pyruvate kinase.
Synergistic effect of ammonium and potassium ions on pyruvate kinase from Ehrlich ascites tumor cells.
The inhibitory effect of L-cysteine and its derivatives on glycolysis in Ehrlich ascites tumour cells.
Carcinoma, Embryonal
Alterations of gene expression in endoderm differentiation of F9 teratocarcinoma cells.
Molecular cloning of the complementary DNA for the mouse pyruvate kinase M-2 gene whose expression is dependent upon cell differentiation.
Phosphofructokinase and pyruvate kinase in mouse embryonal carcinoma P19 cells in relation to growth and differentiation.
Carcinoma, Hepatocellular
2,3'4,4',5-Pentachlorobiphenyl induces hepatocellular carcinoma cell proliferation through pyruvate kinase M2-dependent glycolysis.
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
A comparison of the properties of pyruvate kinase from hepatoma 3924-A, normal liver and muscle.
A new pyruvate kinase isozyme in hepatomas.
Alteration in L-type pyruvate kinase gene expression is not associated with the LF-B1 mRNA level.
cis-acting DNA elements regulating expression of the liver pyruvate kinase gene in hepatocytes and hepatoma cells. Evidence for tissue-specific activators and extinguisher.
Comparison of pyruvate kinase variants from rat liver and Morris hepatoma 7777, obtained by an affinity chromatography on blue sepharose CL-6B.
Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells.
CRAF methylation by PRMT6 regulates aerobic glycolysis driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Expression of hypoxia-inducible genes in tumor cells.
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
Functional studies by site-directed mutagenesis on the role of Sp1 in the expression of the pyruvate kinase M and aldolase A genes.
Gene expression in clonally derived cell lines produced by in vitro transformation of rat fetal hepatocytes: isolation of cell lines which retain liver-specific markers.
Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism.
Hepatic preneoplasia in hepatitis B virus transgenic mice.
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma.
Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps.
Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2.
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
Isozyme differentiation of aldolase and pyruvate kinase in fetal, regenerating, preneoplastic, and malignant rat hepatocytes during culture.
Isozymes of pyruvate kinase in liver and hepatomas of the rat.
Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells.
miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma.
miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells.
Modifications of the expression of liver-specific and non-specific messenger RNAs during azo-dye hepatocarcinogenesis.
Molecular cloning of cDNA sequences for rat M2-type pyruvate kinase and regulation of its mRNA.
Multimolecular forms of pyruvate kinase. II. Purification of M 2 -type pyruvate kinase from Yoshida ascites hepatoma 130 cells and comparative studies on the enzymological and immunological properties of the three types of pyruvate kinases, L, M 1 , and M 2 .
Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.
PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.
PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment.
Pyruvate kinase isoenzymes in altered foci and carcinoma of rat liver.
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma.
Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.
Pyruvate kinase of hepatoma Morris 5123: insensitivity to dietary changes.
Rat hyperplastic hepatic nodules and primary hepatomas retaining abnormally high pyruvate kinase L type activity.
Redox-regulated expression of glycolytic enzymes in resting and proliferating rat thymocytes.
Regulation of genes for glycolytic enzymes in cultured rat hepatoma cell lines.
Regulation of pyruvate kinase in Reuber H35 hepatoma cells by insulin and fructose.
Retention of liver-type pyruvate kinase in cultured rat hepatoma cells.
Role of the GLUT 2 glucose transporter in the response of the L-type pyruvate kinase gene to glucose in liver-derived cells.
SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity.
SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma.
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells.
The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
The M1 and M2 subunits of rat pyruvate kinase are encoded by different messenger RNAs.
TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.
Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.
[Activities of several enzymes of glycolysis and of the glucose shunt in the Albert hepatoma of mouse (author's transl)]
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
[M2-type pyruvate kinase in the diagnosis of hepatocarcinoma--a pilot study]
[Preparation and identification of a monoclonal antibody against recombinant human L-type pyruvate kinase N]
[Properties of pyruvate kinase isozyme from rat ascites hepatoma 13 cells]
[Pyruvate kinase activity in the liver of rats with induced tumors]
[Pyruvate kinase of rat hepatoma, placenta and fetal liver]
[Studies on the isozymes of pyruvate kinase in AH-13 hepatoma (author's transl)]
Carcinoma, Non-Small-Cell Lung
Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer.
Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors.
Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro.
Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population.
[The role of oncomarkers CEA, Cyfra-21, NSE, TU M2-PK in diagnosis and treatment of lung cancer]
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
[Tripartite-motif protein 25 and pyruvate kinase M2 protein expression in non-small cell lung cancer].
Carcinoma, Pancreatic Ductal
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
Carcinoma, Renal Cell
Chaperon?mediated autophagy can promote proliferation and invasion of renal carcinoma cells and inhibit apoptosis through PKM2.
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma.
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.
Pyruvate kinase type tumor M2 in urological malignancies.
The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.
The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
[Renal cell carcinoma. Immunohistological study to the expression of the inactive form of the pyruvate kinase]
[Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
Carcinoma, Small Cell
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Carcinoma, Squamous Cell
An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate.
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Carcinoma, Transitional Cell
Pyruvate kinase type tumor M2 in urological malignancies.
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Carcinosarcoma
[Lactate and pyruvate metabolism in the tissues of rats with Walker carcinosarcoma injected with oxythiamine]
Cardiomyopathy, Dilated
Assessment of PDK4 and TTN gene variants in 48 Doberman Pinschers with dilated cardiomyopathy.
Cell Transformation, Neoplastic
Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells.
Cholangiocarcinoma
Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma.
DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis.
PKM2 upregulation promotes malignancy and indicates poor prognosis for intrahepatic cholangiocarcinoma.
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Cholelithiasis
Treatment and long-term follow-up of extrahepatic biliary obstruction with bilirubin cholelithiasis in a Somali cat with pyruvate kinase deficiency.
Cholera
Independent regulation of pyruvate kinase expression by cyclic AMP and prostaglandin F2 alpha in mouse mastocytoma cells.
Cholestasis
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Successful Liver Transplantation for Adolescent Patient With Pyruvate Kinase Deficiency-induced Cirrhosis.
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Choriocarcinoma
Regulation of thyroid hormone receptor-mediated transcription by a cytosol protein.
Clonorchiasis
Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis.
Coccidiosis
Intestinal injury caused by Eimeria spp. impairs the phosphotransfer network and gain weight in experimentally infected chicken chicks.
Colitis
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1? Production and to Prevent DSS-Induced Colitis in Mice.
Colitis, Ulcerative
Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis.
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.
Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a prospective multicentre comparison of predicting outcomes and monitoring response.
Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation.
Colonic Neoplasms
Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.
Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.
Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 in Colon Cancer Proven with Colonoscopy.
Extracellular pyruvate kinase M2 facilitates cell migration by upregulating claudin-1 expression in colon cancer cells.
Glucose-dependent transcriptional regulation of the human sucrase-isomaltase (SI) gene.
PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer.
Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling.
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.
Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/?-catenin pathway in colon cancer cells.
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
Colorectal Neoplasms
A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines.
A systematic review and meta-analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer.
Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells.
Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming.
Colon cancer screening: which non-invasive filter tests?
Colorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase.
Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK.
Comparison of an established simple office-based immunological FOBT with fecal tumor pyruvate kinase type M2 (M2-PK) for colorectal cancer screening: prospective multicenter study.
Comparison of faecal M2-PK and FIT in a population-based bowel cancer screening cohort.
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.
Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis.
Early Detection of Colorectal Cancer: a Multi-Center Pre-Clinical Case Cohort Study for Validation of a Combined DNA Stool Test.
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells.
Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells.
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
Evaluation of Fecal M2PK as a Diagnostic Marker in Colorectal Cancer.
Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors.
Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps.
Faecal biomarkers do not always identify pre-cancerous lesions in patients who present in primary care with bowel symptoms.
Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention.
Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysis.
Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer.
Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation.
Fecal tumor M2 pyruvate kinase is not a specific biomarker for colorectal cancer screening.
Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
p,p'-Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species-mediated extracellular signal-regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells.
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT.
Prognostic value of plasmatic tumor M2 pyruvate kinase and carcinoembryonic antigen in the survival of colorectal cancer patients.
Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2 (M2-PK) as a screening biomarker for colorectal neoplasia.
Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer.
Pyruvate kinase M2 and its evolving role as a prognostic marker in systemic malignancies besides colorectal carcinomas.
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.
Reply: New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study.
Serum M2-pyruvate kinase: A promising non-invasive biomarker for colorectal cancer mass screening.
Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment.
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer.
The use of M2-pyruvate kinase as a stool biomarker for detection of colorectal cancer in tertiary teaching hospital: A comparative study.
The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.
The value of fecal tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer screening.
Tumor M2 pyruvate kinase as a stool marker for colorectal cancer: stability at room temperature and implications for application in the screening setting.
Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy.
Tumor M2-pyruvate kinase in stool as a biomarker for diagnosis of colorectal cancer: A meta-analysis.
Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.
Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients.
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
[Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer].
[Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma]
[Pyruvate kinase M2 (tumor M2-PK) as a screening tool for colorectal cancer (CRC). A review of current published data]
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Coma
Effect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle.
Communicable Diseases
How I do in front of an hemolytic anemia of unknown etiology?
Increased erythrocytic osmotic fragility in anemic domestic shorthair and purebred cats.
Listeria monocytogenes impairs enzymes of the phosphotransfer network and alters antioxidant/oxidant status in cattle brain structures.
Congenital Abnormalities
Significance of the electrophoretic modifications of defective pyruvate kinase variants. Study of six new observations.
Coronary Artery Disease
Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation.
Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection.
Crohn Disease
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.
Fecal M2-PK in Children with Crohn's Disease: A Preliminary Report.
Fecal M2-pyruvate kinase (M2-PK): A novel marker of intestinal inflammation.
P274. Diagnostic accuracy of fecal calprotectin and M2-pyruvate kinase in the prediction of endoscopic activity Crohn's disease.
Pyruvate Kinase M2 Regulates Apoptosis of Intestinal Epithelial Cells in Crohn's Disease.
Cryptococcosis
Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
Cystic Fibrosis
Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old.
Elevated faecal M2-pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?
Increased activity of four glycolytic enzymes in cultured fibroblasts from cystic fibrosis patients.
Cystinosis
Cysteamine prevents inhibition of thiol-containing enzymes caused by cystine or cystine dimethylester loading in rat brain cortex.
Cysts
Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii.
Effect of antihydatid drugs on carbohydrate metabolism of metacestode of echinococcus granulosus.
Effects of mebendazole, albendazole, and praziquantel on fumarate hydratase, pyruvate kinase, and phosphoenolpyruvate carboxykinase of Echinococcus granulosus cyst wall harbored in mice.
Some glucose metabolic enzymes in various fractions of sarcocysts of Sarcocystis fusiformis of buffalo (Bubalus bubalis).
cytochrome-b5 reductase deficiency
Red cell enzymes.
Dehydration
Crystal structure of enolase indicates that enolase and pyruvate kinase evolved from a common ancestor.
Increased transcript levels and kinetic function of pyruvate kinase during severe dehydration in aestivating African clawed frogs, Xenopus laevis.
Preservative Effect of Polyols on the Stability of Biocatalysts during Short-term Dehydration Stress
Sucrose phosphate synthase activity and the co-ordination of carbon partitioning during sucrose and amino acid accumulation in desiccation-tolerant leaf material of the C4 resurrection plant Sporobolus stapfianus during dehydration.
Dengue
Phosphoproteomic analysis of dengue virus infected U937 cells and identification of pyruvate kinase M2 as a differentially phosphorylated phosphoprotein.
Dental Plaque
Relationship between Pyruvate Kinase Activity and Cariogenic Biofilm Formation in Streptococcus mutans Biotypes in Caries Patients.
Dermatitis, Atopic
[Activity of pyruvate kinase and glucose-6-phosphate dehydrogenase in polymorphonuclear granulocytes of patients with atopic dermatitis in the active stage and in remission]
Dermatofibrosarcoma
[Enzyme patterns in connective tissue proliferations (author's transl)]
Dermatomyositis
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Diabetes Mellitus, Experimental
[Effect of insulin and hydrocortisone on the isoenzyme composition of pyruvate kinase in the rabbit kidney]
[Pyruvate kinase from kidney medulla of rabbits in insulin deficiency]
Diabetes Mellitus, Type 1
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Diabetes Mellitus, Type 2
Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians.
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Diabetic Nephropathies
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Gene Regulatory Effect of Pyruvate Kinase M2 is Involved in Renal Inflammation in Type 2 Diabetic Nephropathy.
Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1? Secretion.
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Diabetic Retinopathy
Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy.
Diphtheria
Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2).
Disseminated Intravascular Coagulation
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Down Syndrome
Blood cell pyruvate kinase activity in translocation Down's syndrome.
Duodenal Neoplasms
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.
Dupuytren Contracture
A comparative study of the activity of lysosomal and main metabolic pathway enzymes in tissue biopsies and cultured fibroblasts from Dupuytren's disease and palmar fascia. On the pathobiochemistry of connective tissue proliferation, I.
Dwarfism
Downregulation of OsPK1, a cytosolic pyruvate kinase, by T-DNA insertion causes dwarfism and panicle enclosure in rice.
Elliptocytosis, Hereditary
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
[Hereditary elliptocytosis and pyruvate kinase deficiency of the erythrocytes]
Encephalomalacia
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Endometrial Hyperplasia
Using Pyruvate Kinase as a Predictor for Patient With Endometrial Cancer Having Complex Hyperplasia With Atypia to Prevent Hysterectomy and Preserve Fertility: Retrospective Immunohistochemical Study.
Endometrial Neoplasms
Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometer.
Enzymes of glucose metabolism in carcinoma of the cervix and endometrium of the human uterus.
Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissues.
Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma.
The effects of PGC-1? on the proliferation and energy metabolism of malignant endometrial cancer cells.
Using Pyruvate Kinase as a Predictor for Patient With Endometrial Cancer Having Complex Hyperplasia With Atypia to Prevent Hysterectomy and Preserve Fertility: Retrospective Immunohistochemical Study.
Equine Infectious Anemia
Equine infectious anemia. Pyruvate kinase deficiency in the red cells of thoroughbred horses.
Esophageal Neoplasms
Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2.
Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms
Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK.
The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells.
Esophageal Squamous Cell Carcinoma
M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh's ESCC and promotes proliferation and migration of ESCC cells.
Plasma?derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
Familial Primary Pulmonary Hypertension
Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.
Fanconi Anemia
Superoxide dismutase and other biochemical disorders in a family with Fanconi's anemia.
Fatty Liver
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1? Transactivation in Steatohepatitis.
Fatty acids modulate the expression of pyruvate kinase and arachidonate-lipoxygenase through PPAR?/CYP2C45 pathway: a link to goose fatty liver.
Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner.
Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2.
PPAR? contributes to PKM2 and HK2 expression in fatty liver.
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Fetal Growth Retardation
Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies.
Pyruvate kinase deficiency complicating pregnancy.
Fetal Nutrition Disorders
Kinetic properties of pyruvate kinase in human maternal leukocytes in fetal malnutrition.
Fibroadenoma
Isozyme patterns of normal, benign, and malignant human breast tissues.
Fibrocystic Breast Disease
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Fibroma
[Enzyme patterns in connective tissue proliferations (author's transl)]
Gallstones
Concomitant laparoscopic splenectomy and cholecystectomy as an effective and minimally invasive treatment of pyruvate kinase deficiency with gallstones.
Gallstone Frequency in Children With Celiac Disease.
Red Blood Cell Enzyme Disorders.
Gastroenteritis
Fecal pyruvate kinase is not suitable for discrimination between inflammatory bowel disease exacerbation and acute gastroenteritis.
Gastrointestinal Diseases
Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers.
The tumor marker tumor M2-PK: an application in the diagnosis of gastrointestinal cancer.
Gastrointestinal Neoplasms
A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
The tumor marker tumor M2-PK: an application in the diagnosis of gastrointestinal cancer.
Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer.
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Gaucher Disease
Linkage disequilibrium of common Gaucher disease mutations with a polymorphic site in the pyruvate kinase (PKLR) gene.
Linkage to Gaucher mutations in the Ashkenazi population: effect of drift on decay of linkage disequilibrium and evidence for heterozygote selection.
Tight linkage of pyruvate kinase (PKLR) and glucocerebrosidase (GBA) genes.
Genetic Diseases, Inborn
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9.
Novel mutations associated with pyruvate kinase deficiency in Brazil.
Prenatal diagnosis for a novel homozygous mutation in PKLR gene in an Indian family.
Glioblastoma
A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2 Induced Glycolytic Reprogramming in Glioblastoma.
A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme.
Assessment of epidermal growth factor receptor status in glioblastomas.
Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis.
Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-?-catenin axis.
Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides.
PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma.
Similar pyruvate kinase modifications in glioblastoma cells by 7?-hydroxycholesterol and glutamine withdrawal.
Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression.
Glioma
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
Comparative Proteomic Analysis of Tumor Mesenchymal-Like Stem Cells Derived from High Grade versus Low Grade Gliomas.
Control of glioma cell death and differentiation by PKM2-Oct4 interaction.
Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
Metabolic state of glioma stem cells and nontumorigenic cells.
Paclitaxel inhibits the migration of CD133+ U251 malignant glioma cells by reducing the expression of glycolytic enzymes.
Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines.
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
Pyruvate kinase m2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.
Severe H1N1-associated acute respiratory failure in immunocompromised children.
The pyruvate kinase isoenzyme shift in human gliomas: a potential marker in the treatment of gliomas.
The Role of Pyruvate Kinase M2 in Cancer Metabolism.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A combined system for the study of glutathione metabolism in erythrocytes.
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
Erythrocyte glucose-6-phosphate dehydrogenase and pyruvate kinase activities in hemoglobin H disease.
Extramedullary blast crisis and hemolytic anemia in a patient with t(3p+;4q-) and rapidly evolving myelogenous leukemia.
Frequency of glutathione reductase, pyruvate kinase and glucose-6-phosphate dehydrogenase deficiency in a Spanish population.
G6PD/PK ratio: a reliable parameter to identify glucose-6-phosphate dehydrogenase deficiency associated with microcytic anemia in heterozygous subjects.
Genetic control of resistance to human malaria.
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Pyruvate kinase deficiency. Association with G6PD deficiency.
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Screening of pyruvate kinase deficiency and G6PD deficiency in Chinese newborn in Hong Kong.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.
[Double erythrocyte enzymopathy. Acquired pyruvate kinase and inherited glucose-6-phosphate dehydrogenase deficiencies]
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
[The importance of determination of ferritin levels in erythrocytes]
[Use of nuclear magnetic resonance in the study of hemolytic anemia. Preliminary report]
glucose-6-phosphate isomerase deficiency
A combined system for the study of glutathione metabolism in erythrocytes.
Red blood cell disorders in Rwandese neonates: screening for sickle cell disease and glucose-6-phosphate dehydrogenase deficiency.
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Glucosephosphate Dehydrogenase Deficiency
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
Erythrocyte glucose-6-phosphate dehydrogenase and pyruvate kinase activities in hemoglobin H disease.
Extramedullary blast crisis and hemolytic anemia in a patient with t(3p+;4q-) and rapidly evolving myelogenous leukemia.
Frequency of glutathione reductase, pyruvate kinase and glucose-6-phosphate dehydrogenase deficiency in a Spanish population.
G6PD/PK ratio: a reliable parameter to identify glucose-6-phosphate dehydrogenase deficiency associated with microcytic anemia in heterozygous subjects.
Genetic control of resistance to human malaria.
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Pyruvate kinase deficiency. Association with G6PD deficiency.
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Screening of pyruvate kinase deficiency and G6PD deficiency in Chinese newborn in Hong Kong.
Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.
[Double erythrocyte enzymopathy. Acquired pyruvate kinase and inherited glucose-6-phosphate dehydrogenase deficiencies]
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
[The importance of determination of ferritin levels in erythrocytes]
glutamate-cysteine ligase deficiency
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
glutathione-disulfide reductase deficiency
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
Hematologic and biochemical observations in Gazella dama, G. dorcas and G. cuvieri.
Glycogen Storage Disease
Muscle pyruvate kinase deficiency: glycogen storage disease or mitochondrial myopathy?
Glycosuria
Neonatal islet cell transplantation in the diabetic rat: effect on hepatic enzyme activity and glucose homeostasis.
Heart Failure
Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI.
Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure.
Puerarin inhibits apoptosis and inflammation in myocardial cells via PPAR? expression in rats with chronic heart failure.
[Hemochromatosis and puryvate kinase deficiency (author's transl)]
Hematologic Diseases
A novel PKLR gene mutation identified using advanced molecular techniques.
Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases.
Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors.
Hematologic Neoplasms
Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors.
Hemochromatosis
A rare combination of two inherited disorders in one patient: pyruvate kinase deficiency and hemochromatosis.
An autopsy case of pyruvate kinase deficiency anemia associated with severe hemochromatosis.
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs.
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Iron status and HFE genotype in erythrocyte pyruvate kinase deficiency: study of Italian cases.
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Pyruvate kinase deficiency causing hemolytic anemia with secondary hemochromatosis in a Cairn terrier.
[Hemochromatosis and puryvate kinase deficiency (author's transl)]
Hemoglobin C Disease
[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]
Hemoglobinopathies
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Hepatitis B
Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2.
Hepatitis C
Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B.
Hereditary Sensory and Autonomic Neuropathies
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
hexokinase deficiency
Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population.
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Hydrops Fetalis
Fetal anaemia due to pyruvate kinase deficiency.
Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency.
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Hyperandrogenism
A nontargeted study of muscle proteome in severely obese women with androgen excess compared with severely obese men and nonhyperandrogenic women.
Hyperbilirubinemia, Neonatal
Neonatal hyperbilirubinemia caused by pyruvate kinase deficiency.
[The clinical and laboratory characteristics of congenital pyruvate kinase deficiency].
Hyperglycemia
From Langerhans islets to pancreas transplantation over the past 30 years: a review with personal contributions.
Identification of allosteric-activating drug leads for human liver pyruvate kinase.
Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets.
Hyperhomocysteinemia
Homocysteine induces energy imbalance in rat skeletal muscle: Is creatine a protector?
T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2.
Hyperinsulinism
Derangement in hepatic enzymes caused by sucrose-drinking and its implication for the development of hyperglycemia in female Wistar fatty rats.
Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis.
Insulin resistance in the obese hyperglycemic (ob/ob) mouse. Failure of hyperinsulinemia to activate hepatic pyruvate kinase (PK).
Possible metabolic implications of pyruvate and lactate accumulation in the liver of pregnant rats.
Hyperlipidemias
[The effect of oral synthetic protease inhibitor (FOY 305) on endocrine pancreas and carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats]
Hypersensitivity
DNase-I hypersensitivity analysis of the L-type pyruvate kinase gene in rats and transgenic mice.
Identification of pyruvate kinase as a novel allergen in whiteleg shrimp (Litopenaeus vannamei) by specific-IgE present in patients with shrimp allergy.
Hypertension
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.
Hypertension, Pulmonary
Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency.
Hyperthyroidism
13C NMR study of gluconeogenesis from labeled alanine in hepatocytes from euthyroid and hyperthyroid rats.
Effect of thyroid hormones on the glycolytic enzyme activity in brain areas of the rat.
Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat.
Hepatic carbon flux after re-feeding. Hyperthyroidism blocks glycogen synthesis and the suppression of glucose output observed in response to carbohydrate re-feeding.
[Intraerythrocytic enzyme activities in euthyroid subjects and hyperthyroid patients before treatment and following stabilization of metabolism using radioiodine therapy]
Hypertriglyceridemia
Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency.
Hypertrophy, Right Ventricular
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Hypervitaminosis A
Early effects of vitamin A toxicity on hepatic glycolysis in rat.
Hypoglycemia
Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion.
Hypogonadism
Decrease of aldolase and pyruvate kinase activity in erythrocytes of individuals with male hypogonadism as an expression of lack of androgen influence on the bone marrow.
Hypohidrosis
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Hypothyroidism
Hormonal control of glucose production and pyruvate kinase activity in isolated rat liver cells: influence of hypothyroidism.
[Effect of thyroid hormones on the activity of pyruvate kinase and lactate dehydrogenase in mature rat brain]
Hypoxia, Brain
[Effect of hypoxia on carbohydrate metabolism in scorpion tissues]
Hypoxia-Ischemia, Brain
PKM2 Aggravates Cerebral Ischemia Reperfusion-Induced Neuroinflammation via TLR4/MyD88/TRAF6 Signaling Pathway.
Infant Nutrition Disorders
[Erythrocyte enzyme activity (glucose-6-phosphate dehydrogenase, pyruvate kinase, catalase) in 13 cases of protein-calorie malnutrition in infants]
Infections
Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Changes in the contents of metabolites and enzyme activities in rice plants responding to Rhizoctonia solani Kuhn infection: activation of glycolysis and connection to phenylpropanoid pathway.
Comparison of gene expression of pyruvate kinase and tryparedoxin peroxidase in metacyclic promastigote forms of Leishmania (L.) tropica and L. major by real-time PCR
Detection of candidal antigens in autoimmune polyglandular syndrome type I.
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Estimating the degree of infection of Plasmodium berghei infected red blood cells by evaluation of pyruvate kinase activity.
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
Flexible Metabolism and Suppression of Latent Enzymes Are Important for Escherichia coli Adaptation to Diverse Environments within the Host.
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum.
Host and Bacterial Glycolysis During Chlamydia trachomatis Infection.
Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways.
Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells.
Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.
Intestinal injury caused by Eimeria spp. impairs the phosphotransfer network and gain weight in experimentally infected chicken chicks.
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma.
Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTR.
Parasitic lung infections.
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Pseudomonas aeruginosa strain PA01 impairs enzymes of the phosphotransfer network in the gills of Rhamdia quelen.
Pyruvate kinase deficiency and malaria.
Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.
Pyruvate kinase is necessary for Brucella abortus full virulence in BALB/c mouse.
Single gene effects in mouse models of host: pathogen interactions.
The pyruvate-tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis.
[Glycolysis and pentose-phosphate pathway ratio in staphylococcus from the female genitalia in norm and dysbiosis]
Infectious Mononucleosis
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency.
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
Infertility
Buccal micronucleus cytome biomarkers in Algerian couples with idiopathic infertility.
Reprogramming homing endonuclease specificity through computational design and directed evolution.
Inflammatory Bowel Diseases
Comparison of a novel fecal marker--fecal tumor pyruvate kinase type M2 (M2-PK) with fecal calprotectin in patients with inflammatory bowel disease: a prospective study.
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity.
Fecal pyruvate kinase is not suitable for discrimination between inflammatory bowel disease exacerbation and acute gastroenteritis.
Fecal pyruvate kinase: A potential new marker for intestinal inflammation in children with inflammatory bowel disease.
P245. Accuracy of fecal M2-Pyruvate Kinase compared with fecal calprotectin to assess endoscopic severity in patients with inflammatory bowel diseases.
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
[Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma]
[Pyruvate kinase M2 (tumor M2-PK) as a screening tool for colorectal cancer (CRC). A review of current published data]
Influenza, Human
Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinase.
Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase.
Insulin Resistance
Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Hypoglycemic effects and modulation of gut microbiota of diabetic mice by saponin from Polygonatum sibiricum.
Insulin resistance in the obese hyperglycemic (ob/ob) mouse. Failure of hyperinsulinemia to activate hepatic pyruvate kinase (PK).
Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM.
Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner.
Insulinoma
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4{alpha}, and CBP.
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter.
Expression of liver type pyruvate kinase in insulinoma cells: involvement of LF-B1 (HNF1).
Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells.
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells.
The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type.
Intestinal Neoplasms
[Intestinal cancer precautions. Stool test for tumor M2 pyruvate kinase]
Intracranial Embolism
Naftidrofuryl oxalate improves impaired brain glucose metabolism after microsphere-induced cerebral embolism in rats.
Iron Deficiencies
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
[The importance of determination of ferritin levels in erythrocytes]
Iron Overload
Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Iron overload associated with congenital pyruvate kinase deficiency and high dose ascorbic acid ingestion.
Iron overload in congenital erythrocyte pyruvate kinase deficiency.
Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study.
Pyruvate kinase deficiency in pregnancy complicated by iron overload.
Red Blood Cell Enzyme Disorders.
The dangers of iron overload in pyruvate kinase deficiency.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ?-thalassemia mouse model.
Unexpectedly high but still asymptomatic iron overload in a patient with pyruvate kinase deficiency.
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
Ischemic Stroke
Correction to: Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities after Ischemic Stroke in Adult Mice.
Ischaemic stroke complicating pyruvate kinase deficiency.
PKM2 promotes neutrophil activation and cerebral thrombo-inflammation: Therapeutic implications for ischemic stroke.
Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.
Jaundice, Neonatal
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt.
Red Blood Cell Enzyme Disorders.
Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.
Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency.
Kidney Failure, Chronic
Effects of chronic renal failure on the regulation of pyruvate kinase.
Energy production, intracellular amino acid pools, and protein synthesis in chronic renal disease.
Kidney Neoplasms
Identification of anti-tumoral feedback loop between VHL? and hnRNPA2B1 in renal cancer.
Overexpressed miR-122-5p Promotes Cell Viability, Proliferation, Migration And Glycolysis Of Renal Cancer By Negatively Regulating PKM2.
Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Tumoral Pyruvate Kinase L/R as a Predictive Marker for the Treatment of Renal Cancer Patients with Sunitinib and Sorafenib.
Klatskin Tumor
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
Leg Ulcer
Pyruvate kinase deficiency and leg ulcers.
[Haemolytic anaemia an leg ulcers due to pyruvate kinase deficiency. report of the second venezuelan family (author's transl)]
Leiomyoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Compensatory alterations in energy homeostasis characterized in uterine tumors from hereditary leiomyomatosis and renal cell cancer.
Leiomyosarcoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Lemierre Syndrome
Lemierre Syndrome in a Patient With Splenectomy Secondary to Pyruvate Kinase Deficiency, Complicated by Heparin Resistance.
Leprosy
Anti-sarcopenic effects of diamino-diphenyl sulfone observed in elderly female leprosy survivors: a cross-sectional study.
Leukemia
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Acquired red cell pyruvate kinase deficiency in acute leukemias.
Acquired red cell pyruvate kinase deficiency in leukemias and related disorders.
Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines.
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities.
Erythrocyte pyruvate kinase activity during chemotherapy in children with leukemia and lymphoma.
Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia.
Isozyme patterns of pyruvate kinase and differentiation of Friend leukemia cells.
Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases.
Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells.
Red cell enzymopathies in leukemias.
Red cell pyruvate kinase in acute leukemia.
SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells.
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.
[A case of familial pyruvate kinase deficiency associated with acute myelomonocytic leukemia]
[Activity of pyruvate kinase in erythrocytes in acute leukemia in children]
[Construction of shRNA eukaryotic expression vectors of pkm2 gene and their effect on drug resistant cell line of acute promyelocytic leukemia]
[Erythrocyte metabolism in patients with acute leukemia and a deficiency of the enzyme pyruvate kinase]
[Relative deficiency of glutathione reductase and or pyruvate kinase in erythrocytes in aplastic anemia and acute leukemia]
Leukemia, Erythroblastic, Acute
Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines.
Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts.
Secondary red cell pyruvate kinase deficiency. II. Biochemical studies for the mechanism of pyruvate kinase deficiency in erythroleukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Isozyme distribution of hexokinase, phosphofructokinase and pyruvate kinase in lymphocytes from patients with chronic lymphocytic leukemia.
Leukemia, Lymphoid
Further studies on migration and colonization of leukemic lymphoblasts in AKR and HSS inbred mice.
Leukemia, Myeloid
[A case of acute granulocytic leukemia with erythrocyte pyruvate kinase deficiency and bone marrow chromosome aberration (author's transl)]
Leukemia, Myeloid, Acute
Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases.
Patient with pyruvate kinase deficiency developed acute myelogenous leukemia.
[The effect of cytostatic therapy on pyruvate kinase activity in the erythrocytes of patients with acute myelocytic leukemia]
Leukemia, Myelomonocytic, Acute
[A case of familial pyruvate kinase deficiency associated with acute myelomonocytic leukemia]
Leukemia, Myelomonocytic, Chronic
Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities.
Leukemia, Promyelocytic, Acute
[Construction of shRNA eukaryotic expression vectors of pkm2 gene and their effect on drug resistant cell line of acute promyelocytic leukemia]
Liver Cirrhosis
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Changes of aldolase and pyruvate kinase isoenzymes during liver cirrhosis induction with carbon tetrachloride and 2-acetylamino-fluorene.
Liver Diseases
Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2.
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn.
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Liver Failure
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Liver Neoplasms
MicroRNA 675 cooperates PKM2 to aggravate progression of human liver cancer stem cells induced from embryonic stem cells.
Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1? and Bcl-xL in culture.
Liver Neoplasms, Experimental
Amino-acid composition of pyruvate kinase M2 isoenzyme variants from rat liver and Morris hepatoma 7777.
Comparison of pyruvate kinase variants from rat liver and Morris hepatoma 7777, obtained by an affinity chromatography on blue sepharose CL-6B.
Electrophoretic pattern of cytosolic pyruvate kinase fractions A and B (type L and M2) from normal rat liver and Morris hepatoma 7777.
N-acetylneuraminic acid, phosphate and thiol groups of pyruvate kinase isoenzymes from Morris hepatoma 7777 and normal rat liver.
Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers.
The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells.
Lung Diseases
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases.
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Lung Neoplasms
A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.
Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer.
Antitumor activity of SR splicing-factor 5 knockdown by downregulating pyruvate kinase M2 in non-small cell lung cancer cells.
Aspirin-triggered resolvin D1 inhibits TGF-?1-induced EMT through the inhibition of the mTOR pathway by reducing the expression of PKM2 and is closely linked to oxidative stress.
Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer.
Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.
Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2.
Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model.
Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC).
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors.
Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro.
Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.
Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells.
Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2.
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1? and pyruvate kinase M2.
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases.
RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway.
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells.
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population.
Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring.
Tumor M2-pyruvate kinase in the follow-up of inoperable lung cancer patients: a pilot study.
Tumor markers in detection of lung cancer.
Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.
[The role of oncomarkers CEA, Cyfra-21, NSE, TU M2-PK in diagnosis and treatment of lung cancer]
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
[Tripartite-motif protein 25 and pyruvate kinase M2 protein expression in non-small cell lung cancer].
Lupus Erythematosus, Systemic
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Lymphadenopathy
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Lymphatic Metastasis
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
Lymphoma
Changes in activities of enzymes related to energy metabolism in canine lymphoma cells.
Erythrocyte pyruvate kinase activity during chemotherapy in children with leukemia and lymphoma.
Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.
Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism.
Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.
Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.
The double dealing of cyclin D1.
Lymphoma, B-Cell
Characteristics of red cell pyruvate kinase (PK) and pyrimidine 5'nucleotidase (P5N) abnormalities in acute leukaemia and chronic lymphoid diseases with leukaemic expression.
HIF-?/PKM2 and PI3K-AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine-induced apoptosis in hippocampal neuronal HT22 cells.
Lymphoma, Large-Cell, Anaplastic
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Erythrocyte pyruvate kinase activity in patients with haematological malignancies.
Lymphoproliferative Disorders
Plasma TM2-PK levels in mycosis fungoides patients.
Malaria
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice.
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum.
Genetic control of resistance to human malaria.
Genetic diversity in human erythrocyte pyruvate kinase.
Human red blood cell polymorphisms and malaria.
Malaria: looking for selection signatures in the human PKLR gene region.
Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9.
Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.
Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model.
Pyruvate Kinase and Fc? Receptor Gene Copy Numbers Associated With Malaria Phenotypes.
Pyruvate kinase deficiency and malaria.
Pyruvate kinase deficiency in mice protects against malaria.
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.
Pyruvate kinase deficiency protects against malaria in humans.
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants.
Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.
Pyruvate kinase in malaria host-parasite interaction.
Red cell glucose-6-phosphate dehydrogenase status and pyruvate kinase activity in a Nigerian population.
The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.
Malaria, Falciparum
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
Malnutrition
Effect of protein malnutrition on the glycolytic and glutaminolytic enzyme activity of rat thymus and mesenteric lymph nodes.
Mastocytoma
Independent regulation of pyruvate kinase expression by cyclic AMP and prostaglandin F2 alpha in mouse mastocytoma cells.
Pyruvate kinase and total protein are regulated differently during growth of P-815 mastocytoma cells.
Regulation of pyruvate kinase expression and growth in mastocytoma cells. I. Initial observations.
Regulation of pyruvate kinase expression and growth in P-815 mastocytoma cells. II. Potential role of prostaglandins.
Medulloblastoma
Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Melanoma
B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.
Metabolic characterization of three hamster melanoma variants.
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.
Tumor type M2 pyruvate kinase (TuM2-PK) as a novel plasma tumor marker in melanoma.
Melanoma, Amelanotic
Metabolic characterization of three hamster melanoma variants.
Melanoma, Experimental
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Meningioma
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
Interaction of M1 and M2 isozymes pyruvate kinase from human tissues with phospholipids.
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
Purification and characterization of human meningioma M2-type pyruvate kinase.
Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine.
Metabolic Diseases
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells.
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats.
Mouth Neoplasms
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells.
Multicystic Dysplastic Kidney
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.
Multiple Myeloma
Erythrocyte enzymes in myelomatosis.
NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase.
Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance.
Muscular Diseases
Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta.
Effect of chronic alcoholism on human muscle glycogen and glucose metabolism.
Functions of vitamin E in reproduction and in prostacyclin and immunoglobulin synthesis in rats.
Is methyl-branching in alpha-tocopherol's "tail" important for its in vivo activity? Rat curative myopathy bioassay measurements of the vitamin E activity of three 2RS-n-alkyl-2,5,7,8-tetramethyl-6-hydroxychromans.
Pinpointing oxidative stress behind the white striping myopathy: depletion of antioxidant defenses, accretion of oxidized proteins and impaired proteostasis.
Plasma activity of pyruvate kinase and glutamic oxalacetic transaminase as indices of myopathy in the vitamin E deficient rat.
Stereoisomers of alpha-tocopheryl acetate. III. Simultaneous determination of resorption-gestation and myopathy in rats as a means of evaluating biopotency ratios of all-rac- and RRR-alpha-tocopheryl acetate.
Vitamin E activity of 1-thio-alpha-tocopherol as measured by the rat curative myopathy bioassay.
[Pyruvate kinase deficiency of erythrocytes in a case of hereditary myopathy]
Muscular Dystrophies
A kindred with red cell pyruvate kinase deficiency.
Blood plasma pyruvate kinase as a marker of muscular dystrophy. Properties in dystrophic chickens and hamsters.
Carrier detection in X-linked recessive (Duchenne) muscular dystrophy: pyruvate kinase isoenzymes and creatine phosphokinase in serum and blood cells.
Estimate of the intrafamilial correlation for serum creatine kinase and pyruvate kinase in females at risk for Duchenne and Becker muscular dystrophies.
Pyruvate kinase and creatine phosphokinase during development of the chicken with muscular dystrophy.
Pyruvate kinase isoenzymes in progressive muscular dystrophy and in acute myocardial infarction.
Serum pyruvate kinase in carriers of Duochenne muscular dystrophy.
Serum pyruvate kinase in different neuromuscular diseases and in carriers of muscular dystrophy.
X chromosome-linked muscular dystrophy (mdx) in the mouse.
[Evaluation of serum pyruvate kinase in patients with Duchenne's muscular dystrophy and carriers. Comparison with other enzyme determinations]
[Serum enzyme dynamics in progressive muscular dystrophies]
Muscular Dystrophy, Duchenne
Decreased creatine kinase activity in cultured Duchenne dystrophic muscle cells.
Detection of carriers of X-linked gene for Duchenne muscular dystrophy by levels of creatine kinase and pyruvate kinase.
Duchenne muscular dystrophy carrier detection using logistic discrimination: serum creatine kinase, hemopexin, pyruvate kinase, and lactate dehydrogenase in combination.
Estimates of conditional heterozygosity risks for young females in Duchenne muscular dystrophy.
Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: implication for genetic risks estimates in Duchenne muscular dystrophy carriers.
Improved detection of Duchenne muscular dystrophy heterozygotes using discriminant analysis of creatine kinase levels.
Plasma pyruvate kinase and creatine kinase activity in Becker muscular dystrophy.
Pyruvate kinase in fetal plasma and amniotic fluid unsuccessful for the prenatal diagnosis of Duchenne muscular dystrophy.
Pyruvate kinase: diagnostic value in neuromuscular disease.
Serum creatine kinase and pyruvate kinase in Duchenne muscular dystrophy carrier detection.
Serum pyruvate kinase in carriers of Duchenne muscular dystrophy.
Serum pyruvate kinase in carriers of Duochenne muscular dystrophy.
[A study on the serum biochemistry in carrier detection of Duchenne muscular dystrophy]
Myelodysplastic Syndromes
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Erythrocyte enzyme activities in myelodysplastic syndromes: elevated pyruvate kinase activity.
Myelodysplastic syndrome in a patient with hereditary pyruvate kinase deficiency.
Myelolipoma
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma.
Myocardial Infarction
HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction.
Pyruvate kinase isoenzymes in progressive muscular dystrophy and in acute myocardial infarction.
Serum enolase and pyruvate kinase activities in the diagnosis of myocardial infarction.
Serum pyruvate kinase in acute myocardial infarction.
[A clinical and experimental study on early diagnosis of myocardial infarct extension by measuring the activity of serum pyruvate kinase]
[Clinical significance of determining plasma pyruvate kinase (PK) activity in acute myocardial infarction (author's transl)]
[Pyruvate kinase in acute myocardial infarct]
Myocarditis
[Study of some properties of rat myocardial pyruvate kinase in adrenaline myocarditis]
Myositis
Dendritic cells presenting pyruvate kinase M1/M2 isozyme peptide can induce experimental allergic myositis in BALB/c mice.
Myotonic Dystrophy
Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.
Nasopharyngeal Carcinoma
Suppressed "Warburg Effect" in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway.
Neoplasm Metastasis
A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Exploring targeted therapy of osteosarcoma using proteomics data.
Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.
Glycolytic enzyme activities in breast cancer metastases.
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
PKM2 in carcinogenesis and oncotherapy.
Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis.
Prognostic value of plasmatic tumor M2 pyruvate kinase and carcinoembryonic antigen in the survival of colorectal cancer patients.
Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.
Pyruvate kinase type tumor M2 in urological malignancies.
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway.
Suppressed "Warburg Effect" in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway.
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions.
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Neoplasms
1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.
2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
?-Catenin, a Wnt/?-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
A cell engineering strategy to enhance the safety of stem cell therapies.
A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2 Induced Glycolytic Reprogramming in Glioblastoma.
A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
A critical challenge in the development of antibody: Selecting the appropriate fragment of the target protein as an antigen based on various epitopes or similar structure.
A critical review of the role of M2PYK in the Warburg effect.
A fuzzy logic controller based approach to model the switching mechanism of the mammalian central carbon metabolic pathway in normal and cancer cells.
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth.
A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.
A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.
A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines.
A pyruvate kinase variant in different mouse transplanted tumors.
A useful EGFR-TK ligand for tumor diagnosis with SPECT: development of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline.
Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer.
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
Action at a distance: allostery and the development of drugs to target cancer cell metabolism.
Activators of PKM2 in cancer metabolism.
Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse.
Activity of enzymes related to carbohydrate metabolism in the HT 29 colon adenocarcinoma cell line and tumor.
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in lipoblastic and neurogenic proliferations.
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.
Advances in the proteomic discovery of novel therapeutic targets in cancer.
Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms.
Affinity elution of pyruvate kinase from phosphocellulose.
Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers.
Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old.
AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth.
Alanine-mediated reversible inactivation of tumour pyruvate kinase caused by a tetramer-dimer transition.
Alterations in erythrocyte enzymes in cancer.
Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma.
Altered glycolysis results in drug-resistant in clinical tumor therapy.
Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.
Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.
Anti-cancer effect of a novel 2,3-didithiocarbamate-substituted naphthoquinone as a tumor metabolic suppressor in vitro and in vivo.
Antigen presentation by dendritic cells in tumors is disrupted by altered metabolism that involves pyruvate kinase M2 and its interaction with SOCS3.
Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes.
Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.
Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies.
Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines.
Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.
Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism.
Association-dissociation behavior of erythrocyte phosphofructokinase and tumor pyruvate kinase.
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction.
Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2.
Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.
Caging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosis.
Cancer abolishes the tissue type-specific differences in the phenotype of energetic metabolism.
Cancer cell metabolism: implications for therapeutic targets.
Cancer metabolism and mass spectrometry-based proteomics.
Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator.
Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry.
Carbohydrate metabolism in neoplastic tissue.
Catalytic and regulatory properties of muscle pyruvate kinase from Cancer magister.
Cellular expression of K-type pyruvate kinase in normal and neoplastic human tissues.
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling.
Changes in PKM2 associate with prostate cancer progression.
Changes in the pyruvate kinase and lactate dehydrogenase activity in rat lung during cultivation and "spontaneous" development of malignancy in vitro.
Characterization of pyruvate kinase from human rhabdomyosarcoma in relation to immunohistochemical and morphological criteria.
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma.
Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridization.
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma.
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹?F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.
Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma.
Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma.
Colorectal cancer detection by biomarker quantification in noninvasively collected colorectal mucus: preliminary comparison of 24 protein biomarkers.
Colorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase.
Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor M2-PK.
Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity.
Comparison of a novel fecal marker--fecal tumor pyruvate kinase type M2 (M2-PK) with fecal calprotectin in patients with inflammatory bowel disease: a prospective study.
Comparison of an established simple office-based immunological FOBT with fecal tumor pyruvate kinase type M2 (M2-PK) for colorectal cancer screening: prospective multicenter study.
Comparison of faecal M2-PK and FIT in a population-based bowel cancer screening cohort.
Comparison of Plasma Tu-M2-PK and CA19-9 in Pancreatic Cancer.
Comparison of pyruvate kinase variants from breast tumor and normal breast.
Comparison of pyruvate kinase variants from rat liver and Morris hepatoma 7777, obtained by an affinity chromatography on blue sepharose CL-6B.
Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer.
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response.
Correlation between Faecal Tumour M2 Pyruvate Kinase and Colonoscopy for the Detection of Adenomatous Neoplasia in a Secondary Care Cohort.
Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.
Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1? inhibition.
Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.
Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2.
DAPk and pyruvate kinase: unlikely partners in cancer metabolic regulation.
Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase.
Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.
Determination of faecal inflammatory marker concentration as a noninvasive method of evaluation of pathological activity in children with inflammatory bowel diseases.
Determination of pyruvate kinase type tumor M2 in human renal cell carcinoma: a suitable tumor marker?
Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors.
Development of [
Deviation of isozyme pattern of pyruvate kinase in the liver of nude mice bearing allogeneic or xenogeneic tumor.
Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum.
Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis.
Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal canhcer.
Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis.
Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 in Colon Cancer Proven with Colonoscopy.
Diagnostic value of tumor M2-pyruvate kinase in neuroendocrine tumors. A comparative study with chromogranin A.
Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter.
Dietary fructose improves intestinal cell survival and nutrient absorption.
Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer.
Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.
Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies.
Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme.
Differential proteomic profiling of chordomas and analysis of prognostic factors.
Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis.
Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis.
Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators.
Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator.
Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing.
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.
Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.
Discrimination between neuronal and glial cell tumours by pyruvate kinase electrophoresis.
DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.
Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis.
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth.
Effect of cyclic polylactates on tumor cells and tumor bearing mice.
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro.
Effects of L-alanine and fructose (1,6-diphosphate) on pyruvate kinase from ehrlich ascites tumour cells.
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.
Efficacy and mechanism of combination of oxaliplatin with PKM2 knockdown in colorectal cancer.
Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model.
Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients.
EGFR-induced and PKC? monoubiquitylation-dependent NF-?B activation upregulates PKM2 expression and promotes tumorigenesis.
Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.
Elevated faecal M2-pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?
Emerging roles of PKM2 in cell metabolism and cancer progression.
Endothelial pyruvate kinase M2 maintains vascular integrity.
Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells.
Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.
Enhanced patterns on intraoperative contrast-enhanced ultrasonography predict outcomes after curative liver resection in patients with hepatocellular carcinoma.
Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids.
Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells.
Enzyme activities and isozyme patterns in human lung tumors.
Enzyme activities in normal, dysplastic, and cancerous human breast tissues.
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Enzyme Kinetic Assay to Measure the Activity of Tumor M2 Pyruvate Kinase in Breast Cancer Patients.
Enzymes in cancer. I. Measurement of pyruvate kinase in serum of normal individuals and patients with cancer.
Enzymes of glucose metabolism in carcinoma of the cervix and endometrium of the human uterus.
Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-?-catenin axis.
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Erythrocyte pyruvate kinase activity in patients with haematological malignancies.
Establishment of renal proximal tubule cell lines by targeted oncogenesis in transgenic mice using the L-pyruvate kinase-SV40 (T) antigen hybrid gene.
Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase isozymes and status of host lipids.
Evaluation of experimental liver tumors using fluorine-18-2-fluoro-2-deoxy-D-glucose PET.
Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23.
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Evaluation of the antiproliferative activity of 106 marine microbial metabolites against human lung cancer cells and potential antiproliferative mechanism of purpuride G.
Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors.
Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma.
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer.
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.
Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer.
Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2.
Exploring the Altered Dynamics of Mammalian Central Carbon Metabolic Pathway in Cancer Cells: A Classical Control Theoretic Approach.
Expression of a new set of glycolytic isozymes in activated human peripheral lymphocytes.
Expression of glucose transporter isoforms (GLUT1, GLUT2) and activities of hexokinase, pyruvate kinase, and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions.
Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.
Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.
Expression of tumor pyruvate kinase M2 isoform in plasma and stool of patients with colorectal cancer or adenomatous polyps.
Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway.
Extraction of a factor from Ehrlich ascites tumor cells that increases the activity of the fetal isozyme of pyruvate kinase in mouse liver.
Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention.
Faecal M2-pyruvate kinase: a novel, noninvasive marker of ileal pouch inflammation.
Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer.
Faecal tumour pyruvate kinase M2: not a good marker for the detection of colorectal adenomas.
Fecal dimeric M2-pyruvate kinase (tumor M2-PK) in the differential diagnosis of functional and organic bowel disorders.
Fecal Markers of Inflammation and Disease Activity in Paediatric Crohn's Disease: Results from the ImageKids Study.
Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening.
Fecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer.
Fecal tumor M2 pyruvate kinase is not a specific biomarker for colorectal cancer screening.
FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells.
Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.
Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells.
From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity.
Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.
Fuzzy logic-based tumor marker profiles including a new marker tumor M2-PK improved sensitivity to the detection of progression in lung cancer patients.
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes.
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.
Gluconeogenic control adaptations in Cancer magister: hypodermal pyruvate kinase, an enzyme with high- and low-affinity states.
Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.
Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF.
Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.
Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma.
Glycolytic enzyme activities in breast cancer metastases.
Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Hepatic glucose-6-phosphatase-? deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma.
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells.
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1? and glycolytic enzymes.
Identification of cytotoxic mediators and their putative role in the signaling pathways during docosahexaenoic acid (DHA)-induced apoptosis of cancer cells.
Identification of Differentiation-Related Proteins in Gastric Adenocarcinoma Tissues by Proteomics.
Identification of five candidate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines.
Identification of Gliotoxin isolated from marine fungus as a new pyruvate kinase M2 inhibitor.
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling.
Identification of small molecule inhibitors of pyruvate kinase M2.
Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.
Immunohistochemical localization of pyruvate kinase isoenzymes in chicken tissues.
Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat.
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Impact of butyrate on PKM2 and HSP90? expression in human colon tissues of different transformation stages: a comparison of gene and protein data.
Impact of quaternary structure dynamics on allosteric drug discovery.
Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK.
In silico investigation of potential pyruvate kinase M2 regulators from traditional Chinese medicine against cancers.
In vitro inhibitory effect of chitosan and its degradation products on energy metabolism in Ehrlich ascites tumour cells (EAT).
In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.
Induction of apoptosis by FFJ-5, a novel naphthoquinone compound, occurs via downregulation of PKM2 in A549 and HepG2 cells.
Influence of insulin on estrogen-induced responses in the r3230ac mammary carcinoma.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer.
Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps.
Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis.
Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2.
Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.
Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors.
Interaction of M1 and M2 isozymes pyruvate kinase from human tissues with phospholipids.
Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.
Interconversion phenomena between two kinetic forms of class a pyruvate kinase from Ehrlich ascites tumor cells.
Interconvertible forms of class A pyruvate kinase from Ehrlich ascites tumour cells.
Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.
Isoform switch of pyruvate kinase m1 indeed occurs but not to pyruvate kinase m2 in human tumorigenesis.
Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization.
Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation.
Isozyme patterns of normal, benign, and malignant human breast tissues.
Isozyme patterns of pyruvate kinase in various primary liver tumors induced during the process of hepatocarcinogenesis.
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1?-mediated glucose metabolism.
Kinetic properties of pyruvate kinase isolated from rat hepatic tumours.
Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells.
Knockdown of PKM2 Enhances Radiosensitivity of Non-small cell Lung Cancer.
Knockdown of PKM2 induces apoptosis and autophagy in human A549 alveolar adenocarcinoma cells.
Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial-mesenchymal transition via Wnt/?-catenin signaling.
Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma.
Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo.
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases.
L-alpha-alanine inhibition of pyruvate kinase from tumors of the human central nervous system.
Lactate does not activate NF-?B in oxidative tumor cells.
Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2.
Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression.
Limited Clinical Significance of Dimeric Form of Pyruvate Kinase as a Diagnostic and Prognostic Biomarker in Non-small Cell Lung Cancer.
Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis.
Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer.
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.
M2-PK as a novel marker in ovarian cancer. A prospective cohort study.
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Mangifera indica Extracts as Novel PKM2 Inhibitors for Treatment of Triple Negative Breast Cancer.
Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides.
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK).
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
Metabolic characterization of three hamster melanoma variants.
Metabolic control of glycolysis in normal and tumor permeabilized cells.
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
Metabolic modulation of cancer: a new frontier with great translational potential.
Metabolic Pathway Alterations that Support Cell Proliferation.
Metabolic signature genes associated with susceptibility to Pyruvate kinase, muscle type 2 gene ablation in cancer cells.
Metabolic vulnerabilities in endometrial cancer.
Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.
Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.
MicroRNA 675 cooperates PKM2 to aggravate progression of human liver cancer stem cells induced from embryonic stem cells.
MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer.
Missense mutations in pyruvate kinase m2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.
Mitochondria, hexokinase and pyruvate kinase isozymes in the aerobic glycolysis of tumor cells.
Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.
Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN.
Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.
Moderate DNA damage promotes metabolic flux into PPP via PKM2 Y-105 phosphorylation: a feature that favours cancer cells.
Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells.
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Molecular docking analysis of pyruvate kinase M2 with a potential inhibitor from the ZINC database.
Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics.
MUC1-C oncoprotein regulates glycolysis and pyruvate kinase m2 activity in cancer cells.
Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissues.
Mutant p53 and mTOR/PKM2 regulation in cancer cells.
N-acetylneuraminic acid, phosphate and thiol groups of pyruvate kinase isoenzymes from Morris hepatoma 7777 and normal rat liver.
Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment.
Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.
NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase.
New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
New faecal tests in gastroenterology.
New links between lipid accumulation and cancer progression.
New roles for pyruvate kinase M2: working out the Warburg effect.
Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways.
Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein.
Nuclear accumulation of pyruvate kinase M2 promotes liver regeneration via activation of signal transducer and activator of transcription 3.
Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2.
Nuclear PKM2 regulates ?-catenin transactivation upon EGFR activation.
Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress.
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
Oleanolic Acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type m isoforms.
On the Origin of ATP Synthesis in Cancer.
Oncogenic kinase-induced PKM2 tyrosine 105 phosphorylation converts non-oncogenic PKM2 to a tumor promoter and induces cancer stem-like cells.
Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.
Optimization of a modeling platform to predict oncogenes from genome-scale metabolic networks of non-small-cell lung cancers.
Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.
Overexpression of metabolic markers PKM2 and LDH5 correlates with aggressive clinicopathological features and adverse patient prognosis in tongue cancer.
Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.
Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma.
Overexpression of pyruvate kinase M2 predicts a poor prognosis for patients with osteosarcoma.
Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2.
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.
Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery.
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1.
Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2.
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer.
Phylogeny congruence analysis and isozyme classification: the pyruvate kinase system.
Phytometabolites Targeting Warburg Effect in Cancer Cells: A Mechanistic Review.
PK-M2 Makes Cells Sweeter on HIF1.
PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
PKM1 is involved in resistance to anti-cancer drugs.
PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.
PKM2 and cancer: The function of PKM2 beyond glycolysis.
PKM2 and HIF-1? regulation in prostate cancer cell lines.
PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer.
PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer.
PKM2 in Canine Mammary Tumors: Parallels to Human Breast Cancer.
PKM2 in carcinogenesis and oncotherapy.
PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.
PKM2 is not required for colon cancer initiated by APC loss.
PKM2 is not required for pancreatic ductal adenocarcinoma.
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.
PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma.
PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop.
PKM2 promotes glucose metabolism through a let-7a-5p/Stat3/hnRNP-A1 regulatory feedback loop in breast cancer cells.
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation.
PKM2 promotes tumor angiogenesis by regulating HIF-1? through NF-?B activation.
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
PKM2 regulates proliferation and apoptosis through the Hippo pathway in oral tongue squamous cell carcinoma.
PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells.
PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer.
PKM2 upregulation promotes malignancy and indicates poor prognosis for intrahepatic cholangiocarcinoma.
PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
PKM2, a potential target for regulating cancer.
PKM2, cancer metabolism, and the road ahead.
PKM2, function and expression and regulation.
PKM2, STAT3 and HIF-1?: The Warburg's vicious circle.
PKM2-dependent glycolysis promotes the proliferation and migration of vascular smooth muscle cells during atherosclerosis.
PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-?1-induced EMT.
PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer.
Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure.
Plasma levels of HER-2/neu, tumor type M2 pyruvate kinase and its tyrosine-phosphorylated metabolite in advanced breast cancer.
Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors.
Plasma TM2-PK levels in mycosis fungoides patients.
Plasma TuM2-PK correlates with tumor size, CRP and CA 15-3 in metastatic breast carcinomas; short versus long term follow up study of the Egyptian breast cancer patients.
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
Point-of-care testing in the diagnosis of gastrointestinal cancers: current technology and future directions.
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.
Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer.
Potential adverse effects to the retina of cancer therapy targeting pyruvate kinase M2.
Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT.
Pre-analytical problems in the measurement of tumor type pyruvate kinase (tumor M2-PK).
Predicting the clinical course of breast cancer patients undergoing trastuzumab-based therapy: an outlook.
Probing Metabolism in the Intact Retina Using Stable Isotope Tracers.
Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer: A meta-analysis.
Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer.
Prognostic value of plasmatic tumor M2 pyruvate kinase and carcinoembryonic antigen in the survival of colorectal cancer patients.
Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis.
Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma.
Prospective multicenter evaluation of fecal tumor pyruvate kinase type M2 (M2-PK) as a screening biomarker for colorectal neoplasia.
Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells.
Protein kinase function of pyruvate kinase M2 and cancer.
Proteomic analysis of the effects of tetramethylpyrazine on irradiated QXMSC1 cells.
Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid.
Proteomic identification of the differentially expressed proteins in human lung epithelial cells by airborne particulate matter.
Proteomic profiling of high risk medulloblastoma reveals functional biology.
Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.
Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.
Purification of pyruvate kinase from Yoshida ascites tumor cells.
Purification of pyruvate kinase isoenzymes type M1 and M2 from dog (Canis familiaris) and comparison of their properties with those from chicken and rat.
Purified pyruvate kinases type M2 from unfertilized hen's egg are substrates of protein kinase C.
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology.
Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.
Pyruvate kinase and phosphofructokinase isozymes in childhood cancers.
Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors.
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle.
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.
Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers.
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.
Pyruvate kinase isozymes and dedifferentiation of (neuro-)ectodermal tumors.
Pyruvate kinase isozymes in various tissues of rat, and increase of spleen-type pyruvate kinase in liver by injecting chromatins from spleen and tumor.
Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.
Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis.
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1? and Bcl-xL in culture.
Pyruvate kinase M2 and cancer: an updated assessment.
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis.
Pyruvate kinase M2 and its evolving role as a prognostic marker in systemic malignancies besides colorectal carcinomas.
Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome.
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Pyruvate kinase M2 at a glance.
Pyruvate Kinase M2 Coordinates Metabolism Switch between Glycolysis and Glutaminolysis in Cancer Cells.
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.
Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma.
Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling.
Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.
Pyruvate kinase M2 in chronic inflammations: a potpourri of crucial protein-protein interactions.
Pyruvate kinase M2 inhibits the progression of bladder cancer by targeting MAKP pathway.
Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation.
Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer.
Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer.
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.
Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration.
Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.
Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis.
Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies.
Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.
Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.
Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells.
Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair.
Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.
Pyruvate Kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity.
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression.
Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment.
Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression.
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.
Pyruvate Kinase Muscle Isoenzyme 2 (PKM2) Expression Is Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma.
Pyruvate kinase type M2 and its role in tumor growth and spreading.
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells.
Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.
Pyruvate kinase type M2: a crossroad in the tumor metabolome.
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells.
Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours.
Pyruvate kinase type tumor M2 in urological malignancies.
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Pyruvate kinase: Function, regulation and role in cancer.
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas.
Quantitative detection of tumor M2-PK in serum and plasma.
Quantitative detection of tumor M2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases.
Quantitative determination of the degree of differentiation of mammary tumors by pyruvate kinase kinetic analysis.
Rat hyperplastic hepatic nodules and primary hepatomas retaining abnormally high pyruvate kinase L type activity.
Rationalization of the Activity Profile of Pyruvate Kinase Isozyme M2 (PKM2) Inhibitors using 3D QSAR.
Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.
Regulation and function of pyruvate kinase M2 in cancer.
Regulation of glycolysis and oxygen consumption in lymph-node cells of normal and leukaemic mice.
Regulation of Metabolism by Hypoxia-Inducible Factor 1.
Regulatory circuit of PKM2/NF-?B/miR-148a/152-modulated tumor angiogenesis and cancer progression.
Relationship between 18-F-fluoro-deoxy-D-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma.
Reply: Faecal tumour pyruvate kinase M2: not a good marker for detection of colorectal adenomas.
Reply: New faecal tests for colorectal cancer screening: is tumour pyruvate kinase M2 one of the options?
Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells.
Resurgence of fetal isozymes in cancer: study of aldolase, pyruvate kinase, lactic dehydrogenase, and beta-hexosaminidase.
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.
RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion.
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.
Role of sp transcription factors in the regulation of cancer cell metabolism.
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions.
Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing.
SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing.
Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/?-catenin pathway in colon cancer cells.
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study.
Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
Serum depletion induces changes in protein expression in the trophoblast-derived cell line HTR-8/SVneo.
Serum tumour M2-pyruvate kinase as a biomarker for diagnosis and prognosis of early-stage non-small cell lung cancer.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1? to overcome apoptosis in a refractory HCC cell line.
Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis.
Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation.
Shikonin, vitamin K3 and vitamin K5 inhibit multiple glycolytic enzymes in MCF-7 cells.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells.
Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice.
Similarities between pyruvate kinase from human placenta and tumours.
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma.
Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis.
Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells.
Small-molecule reprogramming of cancer metabolism.
Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells.
Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment.
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells.
Stimulation of tumor-cell respiration by inhibitors of pyruvate kinase.
STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/?-catenin pathway in cervical carcinoma cells.
Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors.
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Structural insight into mechanisms for dynamic regulation of PKM2.
Study of pyruvate kinase activity in human astrocytomas - Alanine-inhibition test revisted.
Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer.
Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.
Suppressed "Warburg Effect" in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway.
Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis.
Synergistic combination of gemcitabine and dietary molecule induces apoptosis in pancreatic cancer cells and down regulates PKM2 expression.
Synergistic effect of ammonium and potassium ions on pyruvate kinase from Ehrlich ascites tumor cells.
Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors.
Synthesis of novel sulfonamide derivatives containing pyridin-3-ylmethyl 4-(benzoyl)piperazine-1-carbodithioate moiety as potent PKM2 activators.
Tanshinone ?A inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation.
Targeting cancer metabolism.
Targeting cellular metabolism to improve cancer therapeutics.
Targeting PKM2 promotes chemosensitivity of breast cancer cells in vitro and in vivo.
Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.
Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes.
Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
TEPP-46-Based AIE Fluorescent Probe for Detection and Bioimaging of PKM2 in Living Cells.
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer.
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
The Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 for Biliary Tract Carcinoma. A Systematic Review and Meta-Analysis.
The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells.
The effect of levamisole on energy metabolism in Ehrlich ascites tumour cells in vitro.
The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
The impairment of respiration by glycolysis in the Lewis lung carcinoma.
The inhibitory effect of L-cysteine and its derivatives on glycolysis in Ehrlich ascites tumour cells.
The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells.
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
The M2-type isoenzyme of pyruvate kinase phosphorylates prothymosin ? in proliferating lymphocytes.
The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.
The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.
The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus.
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma.
The multifaceted regulation and functions of PKM2 in tumor progression.
The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells.
The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.
The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose.
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.
The role of pyruvate kinase M2 in anticancer therapeutic treatments.
The Role of Pyruvate Kinase M2 in Cancer Metabolism.
The role of the HIF-1?/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.
The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2.
The tumor marker tumor M2-PK: an application in the diagnosis of gastrointestinal cancer.
The tumor metabolome.
The use of M2-pyruvate kinase as a stool biomarker for detection of colorectal cancer in tertiary teaching hospital: A comparative study.
The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.
The Utility of [18F]DASA-23 for Molecular Imaging of Prostate Cancer with Positron Emission Tomography.
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
The value of fecal tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer screening.
The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina.
The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer.
Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids.
Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.
Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis.
Transplacental effects of carcinogens and non-carcinogens on activities of pyruvate kinase and lactate dehydrogenase as well as isozymic pattern of LDH in mouse lung.
TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.
TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation.
TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions.
Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex.
Tumor M2 pyruvate kinase as a stool marker for colorectal cancer: stability at room temperature and implications for application in the screening setting.
Tumor M2 pyruvate kinase in diagnosis of nonsmall cell lung cancer: A meta-analysis based on Chinese population.
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Tumor M2 pyruvate kinase--determination in breast cancer patients receiving trastuzumab therapy.
Tumor M2 pyruvate kinase: a tumor marker and its clinical application in gastrointestinal malignancy.
Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.
Tumor M2-PK levels in haematological malignancies.
Tumor M2-PK: A novel urine marker of bladder cancer.
Tumor M2-pyruvate kinase and pancreatic cancer.
Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis.
Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring.
Tumor M2-pyruvate kinase in stool as a biomarker for diagnosis of colorectal cancer: A meta-analysis.
Tumor M2-pyruvate kinase in the follow-up of inoperable lung cancer patients: a pilot study.
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastro-intestinal cancer.
Tumor marker pyruvate kinase type tumor M2 in patients suffering from diabetic nephropathy.
Tumor markers in detection of lung cancer.
Tumor pyruvate kinase isoenzyme type M2 and immunochemical fecal occult blood test: performance in screening for colorectal cancer.
Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.
Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer.
Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression.
Tumor type M2 pyruvate kinase (TuM2-PK) as a novel plasma tumor marker in melanoma.
Tumor type M2 pyruvate kinase expression in advanced breast cancer.
Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.
Tumor type M2 pyruvate kinase expression in metastatic renal cell carcinoma.
Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures.
Tumor-specific correlation of tumor M2 pyruvate kinase in pre-invasive, invasive and recurrent cervical cancer.
Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells.
Tumour M2-PK as a predictor of surgical outcome in ovarian cancer, a prospective cohort study.
Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients.
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA.
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Up-Regulation of PKM2 Relates to Retinal Ganglion Cell Apoptosis After Light-Induced Retinal Damage in Adult Rats.
Using Pyruvate Kinase as a Predictor for Patient With Endometrial Cancer Having Complex Hyperplasia With Atypia to Prevent Hysterectomy and Preserve Fertility: Retrospective Immunohistochemical Study.
Value of the serum levels of the tumor marker TUM2-PK in pancreatic cancer.
Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
Value of tumor M2-PK in thyroid carcinoma: a pilot study.
Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format.
Versican expression level in cumulus cells is associated with human oocyte developmental competence.
Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2.
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells.
WITHDRAWN: Regulation of Pyruvate Kinase M Switch towards PKM1 by LKB1-AMPK Axis Tolerates Hypoglycemic Stress in Cancer Cells.
[Analysis of the statistical value of various commercially available stool tests - a comparison of one stool sample in correlation to colonoscopy]
[Behavior of serum pyruvate kinase in neoplasms of the skeleton.]
[Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer].
[Development of barcode and proteome profiling of glioblastoma].
[Effects of stromal cells derived from the normal prostate on the glycolysis of prostate cancer cells].
[Estrogen dependence of mammary gland tumors: the mechanisms of the disorder and the evaluation criteria]
[Fecal Biomarker for Colorectal Cancer Diagnosis].
[Hexokinase activity of erythrocytes in cancer patients]
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
[Immunohistologic photometric quantification of pyruvate kinase content of rat tumors]
[Immunologic characterization of pyruvate kinase from Ehrlich-ascite tumor cells]
[Intestinal cancer precautions. Stool test for tumor M2 pyruvate kinase]
[M2-type pyruvate kinase in the diagnosis of hepatocarcinoma--a pilot study]
[Metabolism enzyme controls cancer stemness].
[Novel mechanism for invasion and metastasis involving metabolic enzymes in intractable cancer cells].
[Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma]
[Properties of neoplasm pyruvate kinase]
[Pyruvate kinase activity in the liver of rats with induced tumors]
[The role of oncomarkers CEA, Cyfra-21, NSE, TU M2-PK in diagnosis and treatment of lung cancer]
[The significance of TU M2-PK tumor marker for lung cancer diagnostics]
[Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients]
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Neoplasms, Squamous Cell
Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer.
Nephritis
The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma.
Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
Neuroacanthocytosis
A basis of the acanthocytosis in inherited and acquired disorders.
Neuroblastoma
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Effect of oxygen and glucose availability on the glycolytic rate in neuroblastoma cells under different conditions of culture.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma.
Severe H1N1-associated acute respiratory failure in immunocompromised children.
[Effects of plasminogen, streptokinase and their equimolar complexes with pyruvate kinase on the human neuroblastoma IMR-32 cells]
Neurodegenerative Diseases
Amyloid-? peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.
Neuroectodermal Tumors
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Neuroendocrine Tumors
Diagnostic value of tumor M2-pyruvate kinase in neuroendocrine tumors. A comparative study with chromogranin A.
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Neuromuscular Diseases
Pyruvate kinase: diagnostic value in neuromuscular disease.
Serum pyruvate kinase in different neuromuscular diseases and in carriers of muscular dystrophy.
The importance of serum pyruvate kinase in neuromuscular diseases and carrier states.
[Serum pyruvate kinase (PK) in the diagnosis of neuromuscular diseases]
Non-alcoholic Fatty Liver Disease
Berberine reverses abnormal expression of L-type pyruvate kinase by DNA demethylation and histone acetylation in the livers of the non-alcoholic fatty disease rat.
Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner.
Network analyses identify liver-specific targets for treating liver diseases.
Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2.
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Odontogenic Cysts
Increased M2 Isoform of Pyruvate Kinase in Fibroblasts Contributes to the Growth, Aggressiveness, and Osteoclastogenesis of Odontogenic Keratocysts.
Optic Atrophy, Autosomal Dominant
Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure.
Osteoarthritis
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis.
SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1? and contributes to LIPUS-mediated anti-inflammatory effect.
Osteosarcoma
Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo.
Overexpression of pyruvate kinase M2 predicts a poor prognosis for patients with osteosarcoma.
TRIM58 Interacts with Pyruvate Kinase M2 to Inhibit Tumorigenicity in Human Osteosarcoma Cells.
Osteosclerosis
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs.
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Ovarian Diseases
M2-PK as a novel marker in ovarian cancer. A prospective cohort study.
Ovarian Neoplasms
AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-?B axis.
Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.
Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines.
Follicle-stimulating hormone promoted pyruvate kinase isozyme type M2-induced glycolysis and proliferation of ovarian cancer cells.
Ginsenoside 20(S)?Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells.
iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer.
M2-PK as a novel marker in ovarian cancer. A prospective cohort study.
Metabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer.
MiR-338-3p targets pyruvate kinase M2 and affects cell proliferation and metabolism of ovarian cancer.
Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer.
Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells.
Tumour M2-PK as a predictor of surgical outcome in ovarian cancer, a prospective cohort study.
Pain Insensitivity, Congenital
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Pancreatic Neoplasms
Analysis of in vivo Interaction between RNA Binding Proteins and Their RNA Targets by UV Cross-linking and Immunoprecipitation (CLIP) Method.
Characterization of glycoproteins in pancreatic cyst fluid using a high-performance multiple lectin affinity chromatography platform.
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells.
Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer.
In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.
Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization.
Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells.
MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis.
Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.
Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells.
Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome.
RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion.
Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
TUM2-PK (pyruvate kinase type tumor M2), CA19-9 and CEA in patients with benign, malignant and metastasizing pancreatic lesions.
Tumor M2-pyruvate kinase and pancreatic cancer.
Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis.
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Tumor marker M2-pyruvate-kinase in differential diagnosis of chronic pancreatitis and pancreatic cancer.
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer.
Value of the serum levels of the tumor marker TUM2-PK in pancreatic cancer.
Pancreatitis, Chronic
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia.
Tumor M2-pyruvate kinase, a new metabolic marker for pancreatic cancer.
Tumor marker M2-pyruvate-kinase in differential diagnosis of chronic pancreatitis and pancreatic cancer.
Pancytopenia
[Decrease of erythrocyte pyruvate kinase activity and foetal haemoglobin rising in pancytopenia (author's transl)]
Papilloma
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.
Parasitemia
Estimating the degree of infection of Plasmodium berghei infected red blood cells by evaluation of pyruvate kinase activity.
Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J.
Parkinson Disease
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Increased Striatal mRNA and Protein Levels of the Immunophilin FKBP-12 in Experimental Parkinson's Disease and Identification of FKBP-12-Binding Proteins.
Parvoviridae Infections
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency.
Periodontal Diseases
Pyruvate Kinase, Inflammation and Periodontal Disease.
Persistent Infection
Chlamydophila (Chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype.
Phenylketonurias
Alanine prevents the in vitro inhibition of glycolysis caused by phenylalanine in brain cortex of rats.
Combined phenylketonuria and pyruvate kinase deficiency. A case report.
Phenylketonuria, pyruvate kinase deficiency and Kouska'a fallacy.
Phenylketonuria: phenylalanine inhibits brain pyruvate kinase in vivo.
Pheochromocytoma
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction.
phosphoglycerate kinase deficiency
Glucose phosphate isomerase (GPI) Tadikonda: Characterization of a novel Pro340Ser mutation.
Pleural Effusion
Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures.
Polycythemia
Hereditary pyruvate kinase abnormalities associated with erythrocytosis.
[Pyruvate kinase, 2,3 bisphosphoglycerate and fibrin-fibrinogen degradation products in patients with polycythemia, before and after erythrapheresis therapy]
Polycythemia Vera
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Potassium Deficiency
[Metabolic abnormality in erthyrocytes with atypical pyruvate kinase and potassium deficiency]
Pouchitis
Fecal pyruvate kinase (M2-PK): a new predictor for inflammation and severity of pouchitis.
Pre-Eclampsia
Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsia.
Pyruvate kinase deficiency complicating pregnancy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Preleukemia
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Primary Myelofibrosis
Atypical intraerythrocytic pyruvate kinase in some haematological diseases.
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Prostatic Hyperplasia
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
Prostatic Neoplasms
PKM2 and HIF-1? regulation in prostate cancer cell lines.
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis.
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.
Pyruvate kinase type tumor M2 in urological malignancies.
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.
Tumor M2 pyruvate kinase in plasma of patients with urological tumors.
[Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis].
Protein-Energy Malnutrition
[Erythrocyte enzyme activity (glucose-6-phosphate dehydrogenase, pyruvate kinase, catalase) in 13 cases of protein-calorie malnutrition in infants]
Proteinuria
Pre-analytical problems in the measurement of tumor type pyruvate kinase (tumor M2-PK).
Psoriasis
Granulocyte pyruvate kinase in psoriasis vulgaris and psoriasis arthropathica.
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
[Pyruvate kinase activity in the granulocytes of patients with psoriasis]
Pulmonary Arterial Hypertension
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.
Pulmonary Atelectasis
Superoxide dismutase and cytochrome oxidase in collapsed lungs: possible role in reexpansion edema.
Pulmonary Disease, Chronic Obstructive
Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease.
pyruvate kinase deficiency
2,3-Diphosphoglycerate and 3-phosphoglycerate in red cell pyruvate kinase deficiency.
A CASE OF CONGENITAL ATYPICAL HAEMOLYTIC ANAEMIA WITH PYRUVATE KINASE DEFICIENCY.
A case of congenital red cell pyruvate kinase deficiency associated with hereditary stomatocytosis.
A case of haemolytic anaemia due to pyruvate kinase deficiency.
A case of severe pyruvate kinase deficiency in a primigravida: successful outcome.
A Case With Pyruvate Kinase Deficiency Remarkably Sensitive to Heat.
A combined system for the study of glutathione metabolism in erythrocytes.
A Family Affected by a Life-Threatening Erythrocyte Defect Caused by Pyruvate Kinase Deficiency With Normal Iron Status: A Case Report.
A kindred with red cell pyruvate kinase deficiency.
A low Km phosphoenolpyruvate mutant in the Amish with red cell pyruvate kinase deficiency.
A modified screening procedure to detect pyruvate kinase deficiency.
A monomeric form of pyruvate kinase in human pyruvate kinase deficiency.
A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency.
A new sickle cell disease phenotype associating Hb S trait, severe pyruvate kinase deficiency (PK Conakry), and an alpha2 globin gene variant (Hb Conakry).
A new variant of erythrocyte pyruvate kinase - PK "maebashi".
A New Variant of PKLR Gene Associated With Mild Hemolysis may be Responsible for the Misdiagnosis in Pyruvate Kinase Deficiency.
A new variant of red blood cell pyruvate kinase deficiency.
A Novel and a Previously Described Compound Heterozygous PKLR Gene Mutations Causing Pyruvate Kinase Deficiency in a Chinese Child.
A novel mutation causing pyruvate kinase deficiency responsible for a severe neonatal respiratory distress syndrome and jaundice.
A novel PKLR gene mutation identified using advanced molecular techniques.
A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency.
A pyruvate kinase deficiency child with novel PK-LR gene mutations was successfully cured by matched unrelated donor peripheral blood stem cell transplantation.
A rare combination of two inherited disorders in one patient: pyruvate kinase deficiency and hemochromatosis.
A SCREENING METHOD FOR THE DETECTION OF ERYTHROCYTE PYRUVATE KINASE DEFICIENCY.
A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.
A Spanish family with erythrocyte pyruvate kinase deficiency: contribution of various immunologic methods in the study of the mutant enzyme.
A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report.
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency.
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Acquired pyruvate kinase deficiency.
Acquired pyruvate kinase deficiency. The effect of maleic acid upon human erythrocyte pyruvate kinase.
Acquired red cell pyruvate kinase deficiency in acute leukemias.
Acquired red cell pyruvate kinase deficiency in leukemias and related disorders.
Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency.
Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro.
Adoptive immunotherapy to increase the level of donor hematopoietic chimerism after nonmyeloablative marrow transplantation for severe canine hereditary hemolytic anemia.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases.
Allogeneic hematopoietic stem cell transplantation in a 3-year-old boy with congenital pyruvate kinase deficiency: A case report.
Alu element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients.
An autopsy case of pyruvate kinase deficiency anemia associated with severe hemochromatosis.
Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers.
Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia.
Anesthesia management for ENT surgery in a child with X-linked pyruvate kinase deficiency.
Animal model of human disease: pyruvate kinase deficiency.
Anomalous pyruvate kinase deficiency in the Basenji dog.
Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency.
Appraisal of patient-reported outcome measures in analogous diseases and recommendations for use in phase II and III clinical trials of pyruvate kinase deficiency.
Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE).
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice.
Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat.
Biochemical and molecular characterization of variant pyruvate kinase enzymes and genes from three patients with red blood cell pyruvate kinase deficiency.
Biochemical characterization of three mutant isozymes of erythrocyte pyruvate kinase: PK-"Gainesville," PK-"San Juan," and PK-"Cape Canaveral".
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Calculation of surface area and volume of human erythrocytes from scanning electron micrographs.
Canine erythrocyte pyruvate kinase. I. Properties of the normal enzyme.
Canine erythrocyte pyruvate kinase. II. Properties of abnormal enzyme associated with hemolytic anemia in the Basenji dog.
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review.
Case report: pyruvate kinase deficiency.
Characterization of the severe phenotype of pyruvate kinase deficiency.
Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.
Chronic haemolytic anaemia in two patients heterozygous for erythrocyte pyruvate kinase deficiency. Electrofocusing and immunological studies of erythrocyte and liver pyruvate kinase.
Chronic myelomonocytic leukemia associated with hereditary pyruvate kinase deficiency and multiple acquired erythrocyte abnormalities.
Clinical and Molecular Spectrum of Glucose-6-Phosphate Isomerase Deficiency. Report of 12 New Cases.
Clinical course of pyruvate kinase deficiency in Abyssinian and Somali cats.
Clinical heterogeneity of erythrocyte pyruvate kinase deficiency. Evidence of an impaired utilization of ATP in a clinically severe form.
Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency.
Coexistence of alpha-thalassemia and a new pyruvate kinase variant: PK Fukien.
Coexistence of congenital red cell pyruvate kinase and band 3 deficiency.
Combined phenylketonuria and pyruvate kinase deficiency. A case report.
Comorbidities and complications in adults with pyruvate kinase deficiency.
Compound heterozygosity in PKLR gene for a previously unrecognized intronic polymorphism and a rare missense mutation as a novel cause of severe pyruvate kinase deficiency.
Concise review: pyruvate kinase deficiency: historical perspective and recent progress of molecular genetics.
Concomitant laparoscopic splenectomy and cholecystectomy as an effective and minimally invasive treatment of pyruvate kinase deficiency with gallstones.
Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.
Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency.
Congenital Hemolytic Anemias: Is There a Role for the Immune System?
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. I. Erythrokinetic patterns.
Congenital non-spherocytic haemolytic anaemia variants with primary and secondary pyruvate kinase deficiency. II. Enzymatic studies.
Consensus document for the diagnosis and treatment of pyruvate kinase deficiency.
Consequences at mRNA level of the PKLR gene splicing mutations IVS10(+1)G-->C and IVS8(+2)T-->G causing pyruvate kinase deficiency.
Cord blood transplantation in a young child with pyruvate kinase deficiency.
Correction to: Clinical approach to neurodegenerative disorders in childhood: an updated overview.
Correction: Stem Cell Selection In Vivo Using Foamy Vectors Cures Canine Pyruvate Kinase Deficiency.
Deferasirox in pyruvate kinase deficiency.
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
Detection of G6PD and pyruvate kinase deficiencies in reticulocytosis by reference to erythrocyte creatine.
Determination of erythrocyte pyruvate kinase deficiency in Basenjis with chronic hemolytic anemia.
Development of the pyruvate kinase deficiency diary and pyruvate kinase deficiency impact assessment: Disease-specific assessments.
Diagnosis of pyruvate kinase deficiency in a transfusion-dependent patient with severe hemolytic anemia.
Diagnosis of Pyruvate Kinase Deficiency.
Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene causes severe pyruvate kinase deficiency.
Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.
Effect of riboflavin treatment on human red cell pyruvate kinase deficiency.
Electrophoretic demonstration of heterozygosis in hereditary pyruvate kinase deficiency. An unusual method.
Electrophoretic, immunologic and kinetic characterization of erythrocyte pyruvate kinase in the Basenji dog with pyruvate kinase deficiency.
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
Equine infectious anemia. Pyruvate kinase deficiency in the red cells of thoroughbred horses.
Erythrocytapheresis as a novel treatment option for adult patients with pyruvate kinase deficiency.
Erythrocyte enzyme deficiencies. Pyruvate kinase deficiency.
Erythrocyte fructose 2,6-bisphosphate content in congenital hemolytic anemias.
Erythrocyte PK deficiency: biochemical characterization of a patient with haemolytic anemia.
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. I. Cell morphology.
Erythrocyte populations in pyruvate kinase deficiency anaemia following splenectomy. II. Cell deformability.
Erythrocyte pyruvate kinase deficiency associated with kinetically aberrant isozyme.
Erythrocyte pyruvate kinase deficiency in a beagle dog.
Erythrocyte pyruvate kinase deficiency in an old-order Amish cohort: Longitudinal risk and disease management.
Erythrocyte pyruvate kinase deficiency in newborns of eastern Saudi Arabia.
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers?
Erythrocyte pyruvate kinase deficiency in the Ohio Amish: origin and characterization of the mutant enzyme.
Erythrocyte pyruvate kinase deficiency in three West Highland white terriers in Ireland and the UK.
Erythrocyte pyruvate kinase deficiency mutation identified in multiple breeds of domestic cats.
ERYTHROCYTE PYRUVATE KINASE DEFICIENCY RESULTING IN CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia.
Erythrocyte pyruvate kinase deficiency. A kinetic study of the membrane-localised and cytoplasmatic enzyme from six patients.
Erythrocyte pyruvate kinase deficiency. The influence of physiologically important metabolites on the function of normal and defective enzymes.
Erythrocyte pyruvate kinase deficiency: 11 new cases.
Erythrocyte pyruvate kinase deficiency: 2015 status report.
Erythrocyte pyruvate kinase deficiency: a kinetic method for differentiation between heterozygosity and compound-heterozygosity.
Erythrocyte pyruvate kinase deficiency: characterization of a new variant (PK "Aarau").
Erythrocyte pyruvate kinase deficiency: relations of residual enzyme activity, altered regulation of defective enzymes and concentrations of high-energy phosphates with the severity of clinical manifestation.
Erythrocytic pyruvate kinase deficiency and AB blood types in Australian Abyssinian and Somali cats.
Erythrocytic pyruvate kinase deficiency and hemolytic anemia inherited as a dominant trait.
Erythropoiesis: Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency.
Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population.
Evaluation of eosin-5-maleimide flow cytometric test in diagnosis of hereditary spherocytosis.
Ex vivo analysis of aberrant splicing induced by two donor site mutations in PKLR of a patient with severe pyruvate kinase deficiency.
Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications.
Exploring putative molecular mechanisms of human pyruvate kinase enzyme deficiency and its role in resistance against Plasmodium falciparum malaria.
EXTREME HEMOLYSIS AND RED-CELL DISTORTION IN ERYTHROCYTE PYRUVATE KINASE DEFICIENCY. I. MORPHOLOGY, ERYTHROKINETICS AND FAMILY ENZYME STUDIES.
EXTREME HEMOLYSIS AND RED-CELL DISTORTION IN ERYTHROCYTE PYRUVATE KINASE DEFICIENCY. II. MEASUREMENTS OF ERYTHROCYTE GLUCOSE CONSUMPTION, POTASSIUM FLUX AND ADENOSINE TRIPHOSPHATE STABILITY.
Failure of partial splenectomy to ameliorate the anemia of pyruvate kinase deficiency.
Familial haemolytic anaemia due to pyruvate kinase deficiency.
Fetal anaemia due to pyruvate kinase deficiency.
First reported case of prenatal diagnosis for pyruvate kinase deficiency in a Chinese family.
First-trimester prenatal diagnosis of pyruvate kinase deficiency in an Indian family with the pyruvate kinase-Amish mutation.
Fragility of abnormal erythrocytes evaluated by response to shear stress.
Frame shift mutation, exon skipping, and a two-codon deletion caused by splice site mutations account for pyruvate kinase deficiency.
Frequency of erythrocyte pyruvate kinase deficiency in Chinese infants.
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.
Gene symbol: PKLR. Disease: Pyruvate kinase deficiency.
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Genetic control of resistance to human malaria.
Genetic test for pyruvate kinase deficiency of Basenjis.
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt.
Glycolate kinase activity in human red cells.
Haemolysis due to pyruvate kinase deficiency and other glycolytic enzymopathies.
Haemolytic anaemia due to pyruvate kinase deficiency.
Health-Related Quality of Life and Fatigue in Children and Adults with Pyruvate Kinase Deficiency.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Hemochromatosis and pyruvate kinase deficiency. Report of a case and review of the literature.
Hemolytic anemia and pyruvate kinase deficiency in pregnancy.
Hemolytic anemia due to pyruvate kinase deficiency: characterization of the enzymatic activity from eight patients.
Hemolytic anemia in pregnancy associated with erythrocyte pyruvate kinase deficiency.
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma.
Hepatosplenomegaly as the only prenatal finding in a fetus with pyruvate kinase deficiency anemia.
Hepcidin and Anemia: A Tight Relationship.
Hereditary disorders of enzymes in the Embden-Meyerhof pathway of glycolysis.
Hereditary disorders of red cell enzymes in the Embden-Meyerhof pathway.
Hereditary erythrocyte pyruvate kinase deficiency: molecular and functional studies of four mutant PK variants detected in Spain.
Hereditary nonspherocytic hemolytic anemia due to pyruvate kinase deficiency: a prevalence study in Quebec (Canada).
Hereditary pyruvate kinase deficiency: role of the abnormal enzyme in red cell pathophysiology.
Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families.
Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases.
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.
Homozygous pyruvate kinase deficiency in Hong Kong ethnic minorities.
How I do in front of an hemolytic anemia of unknown etiology?
How we manage patients with pyruvate kinase deficiency.
Human erythrocyte pyruvate kinase deficiency: the use of a kinetic study of mutant enzymes for the detection of heterozygotes.
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia.
Human red blood cell polymorphisms and malaria.
Hydrops fetalis associated with erythrocyte pyruvate kinase deficiency.
Hydrops fetalis associated with red cell pyruvate kinase deficiency.
Identification and in silico characterization of a novel PKLR genotype in a Turkish newborn.
Identification of a 6 base pair insertion in West Highland White Terriers with erythrocyte pyruvate kinase deficiency.
Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.
Impaired erythrocyte phosphoribosylpyrophosphate formation in hemolytic anemia due to pyruvate kinase deficiency.
Improving the laboratory diagnosis of pyruvate kinase deficiency.
In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.
Increased adsorption of cytoplasmic proteins to the erythrocyte membrane in ATP-depleted normal and pyruvate kinase-deficient mature cells and reticulocytes.
Increased erythrocyte deformability in fetal erythropoiesis and in erythrocytes deficient in glucose-6-phosphate dehydrogenase and other glycolytic enzymes.
Increased IgG molecules bound to the surface of red blood cells of patients with sickle cell anemia.
Ineffective erythropoiesis in the spleen of a patient with pyruvate kinase deficiency.
Influence of the rebox state of glutathione upon pyruvate kinase in the intact erythrocyte.
Inherited erythrocyte pyruvate kinase deficiency in a beagle dog.
Inherited erythrocyte pyruvate kinase deficiency: Studies on 15 members of two related families.
Inherited pyruvate kinase deficiency and normal haematologic values in Australian Basenji dogs.
Inhibition of erythrocyte glycolysis associated with tranylcypromine (MAOinhibitor) administration in rabbits: pyruvate kinase deficiency.
Inhibition of the pentose phosphate shunt by 2,3-diphosphoglycerate in erythrocyte pyruvate kinase deficiency.
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Investigations of the kinetics of red cell pyruvate kinase in normal individuals and in a patient with pyruvate kinase deficiency.
In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9.
Iron overload associated with congenital pyruvate kinase deficiency and high dose ascorbic acid ingestion.
Iron overload in congenital erythrocyte pyruvate kinase deficiency.
Iron status and HFE genotype in erythrocyte pyruvate kinase deficiency: study of Italian cases.
Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.
Iron status in red cell pyruvate kinase deficiency: study of Italian cases.
Ischaemic stroke complicating pyruvate kinase deficiency.
Kinetic properties of mutant enzymes in erythrocyte phosphofructokinase deficiency and erythrocyte pyruvate kinase deficiency.
Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency.
Laboratory studies of erythrocytic pyruvate kinase deficiency. Pathogenesis of the hemolysis.
Large animal models for foamy virus vector gene therapy.
Lemierre Syndrome in a Patient With Splenectomy Secondary to Pyruvate Kinase Deficiency, Complicated by Heparin Resistance.
Life-span and organ sequestration of the red cells in pyruvate kinase deficiency.
Liver cirrhosis as a consequence of iron overload caused by hereditary nonspherocytic hemolytic anemia.
Long-term survival and reversal of iron overload after marrow transplantation in dogs with congenital hemolytic anemia.
Malaria: looking for selection signatures in the human PKLR gene region.
Management of pyruvate kinase deficiency in children and adults.
Mathematical modelling of metabolic pathways affected by an enzyme deficiency. A mathematical model of glycolysis in normal and pyruvate-kinase-deficient red blood cells.
Membrane-localized pyruvate kinase of red blood cells in hemolytic anemia associated with pyruvate kinase deficiency.
Mitral Valve Replacement With Cardiopulmonary Bypass in a Patient With Pyruvate Kinase Deficiency.
Modulating erythrocyte chimerism in a mouse model of pyruvate kinase deficiency.
Molecular abnormality of erythrocyte pyruvate kinase deficiency in the Amish.
Molecular alterations in congenital erythrocyte pyruvate kinase deficiencies.
Molecular Analyses of Pyruvate Kinase Deficient Turkish Patients from a Single Center.
Molecular and clinical heterogeneity in pyruvate kinase deficiency in India.
Molecular aspects of erythroenzymopathies associated with hereditary hemolytic anemia.
Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene.
Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients. Red Cell Pathology Group of the Spanish Society of Haematology (AEHH).
Molecular characterization of the PK-LR gene in sixteen pyruvate kinase-deficient patients.
Molecular genetic testing enabled the diagnosis of otherwise undiagnosable cases of pyruvate kinase deficiency.
Molecular heterogeneity of pyruvate kinase deficiency.
Molecular mechanism of erythrocyte pyruvate kinase deficiency.
Moya moya syndrome in a child with pyruvate kinase deficiency and combined prothrombotic factors.
Multiple exchange transfusions in the treatment of a newborn with pyruvate kinase deficiency.
Muscle pyruvate kinase deficiency: glycogen storage disease or mitochondrial myopathy?
Mutations in the R-type pyruvate kinase gene and altered enzyme kinetic properties in patients with hemolytic anemia due to pyruvate kinase deficiency.
Myelodysplastic syndrome in a patient with hereditary pyruvate kinase deficiency.
Neonatal hemolysis due to a transient severity of inherited pyruvate kinase deficiency.
Neonatal hyperbilirubinemia caused by pyruvate kinase deficiency.
Neutrophil pyruvate kinase deficiency with recurrent staphylococcal infections: first reported case.
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Next-Generation Sequencing-Based Diagnosis of Unexplained Inherited Hemolytic Anemias Reveals Wide Genetic and Phenotypic Heterogeneity.
Nonspherocytic haemolytic anaemia and severe jaundice in a newborn with partial pyruvate kinase deficiency.
Normalisation of red blood cell pyruvate kinase in pyruvate kinase deficiency by riboflavin treatment.
Novel human pathological mutations. Gene symbol: PKLR. Disease: pyruvate kinase deficiency.
Novel mutations and structural implications in R-type pyruvate kinase-deficient patients from Southern Italy.
Novel mutations associated with pyruvate kinase deficiency in Brazil.
Novel PLKR mutations in four families with pyruvate kinase deficiency.
On the molecular basis of pyruvate kinase deficiency.
On the molecular basis of pyruvate kinase deficiency. I. Primary defect or conseqence of increased glutathione disulfide concentration.
Parasitic lung infections.
Paravertebral extramedullary haemopoiesis associated with pyruvate kinase deficiency.
Paravertebral extramedullary hematopoiesis due to pyruvate kinase deficiency.
Paravertebral Mass and Diffuse Lymphadenopathy in a Patient with Pyruvate Kinase Deficiency: Malignancy or Alternative Etiology?
Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 deficiency in a family with hereditary spherocytosis.
Patient with pyruvate kinase deficiency developed acute myelogenous leukemia.
Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model.
Phenylketonuria, pyruvate kinase deficiency and Kouska'a fallacy.
PK Aarau: first homozygous nonsense mutation causing pyruvate kinase deficiency.
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase deficiency.
Preclinical studies of efficacy thresholds and tolerability of a clinically ready lentiviral vector for pyruvate kinase deficiency treatment.
Prenatal diagnosis for a novel homozygous mutation in PKLR gene in an Indian family.
Prenatal diagnosis of pyruvate kinase deficiency.
Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study.
Prevalence of erythrocyte pyruvate kinase deficiency and normal values of enzyme in a Turkish population.
Prevalence of pyruvate kinase deficiency among the Chinese: determination by the quantitative assay.
Prevalence of pyruvate kinase deficiency among the south Iranian population: quantitative assay and molecular analysis.
Prevalence of pyruvate kinase deficiency in northern European population in the north of England. Northern Region Haematologists Group.
Prevalence of pyruvate kinase deficiency: A systematic literature review.
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic.
Pyruvate kinase deficiency anaemia in a Basenji dog.
Pyruvate kinase deficiency and delayed clinical response to recombinant human erythropoietin treatment.
Pyruvate kinase deficiency and leg ulcers.
Pyruvate kinase deficiency and malaria.
Pyruvate kinase deficiency and other enzymopathies of the Embden--Meyerhof pathway.
Pyruvate kinase deficiency and related disorders of red cell glycolysis.
Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-line de novo mutation.
Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.
Pyruvate kinase deficiency as a cause of extreme hyperbilirubinemia in neonates from a polygamist community.
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn.
Pyruvate kinase deficiency causing hemolytic anemia with secondary hemochromatosis in a Cairn terrier.
Pyruvate kinase deficiency complicating pregnancy.
Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice.
Pyruvate kinase deficiency hemolytic anemia: enzymatic characterization studies in twelve patients.
Pyruvate kinase deficiency hemolytic anemia: two successful pregnancy outcomes.
Pyruvate kinase deficiency in a newborn with extramedullary hematopoiesis in the skin.
Pyruvate kinase deficiency in a Somali cat in Australia.
Pyruvate kinase deficiency in a South African kindred caused by a 1529A mutation in the PK-LR gene.
Pyruvate kinase deficiency in an alpha-thalassemia family: first case report in Thailand.
Pyruvate kinase deficiency in children.
Pyruvate kinase deficiency in dog and human erythrocytes: effects of energy depletion on cation composition and cellular hydration.
Pyruvate kinase deficiency in France: a 3-year study reveals 27 new mutations.
Pyruvate kinase deficiency in mice protects against malaria.
Pyruvate kinase deficiency in pregnancy complicated by iron overload.
Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.
Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation.
Pyruvate kinase deficiency protects against malaria in humans.
Pyruvate Kinase Deficiency which Causes Nonspherocytic Hemolytic Anemia: The Gene and its Mutations.
Pyruvate kinase deficiency.
Pyruvate kinase deficiency. Association with G6PD deficiency.
Pyruvate kinase deficiency: an unusual cause of puerperal jaundice.
Pyruvate kinase deficiency: characterization of two new genetic variants.
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants.
Pyruvate kinase deficiency: novel mutations and a better understanding of the genotype-to-phenotype correlation in Brazilian patients.
Pyruvate kinase deficiency: prevalence of the 1456C-->T mutation in the Portuguese population.
Pyruvate kinase deficiency: the genotype-phenotype association.
Pyruvate kinase deficient hemolytic anemia in the Northern Irish population.
Pyruvate kinase-catalyzed ATP-formation in human red blood cell membranes.
Quinine protects pyruvate-kinase deficient red cells from dehydration.
Rapid flow cytometric test using eosin-5-maleimide for diagnosis of red blood cell membrane disorders.
Rapid micromethod for the preparation of leucocyte-free haemolysates for the determinaton of pyruvate kinase and other erythrocyte enzymes.
Real-time PCR genotyping assay for feline erythrocyte pyruvate kinase deficiency and mutant allele frequency in purebred cats in Japan.
Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency.
Red Blood Cell Enzyme Disorders.
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
Red cell 3-phosphoglycerate level as a diagnostic aid in pyruvate kinase deficiency.
Red cell glycolytic enzyme disorders caused by mutations: an update.
Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.
Red cell pyruvate kinase deficiency in Southern Sardinia.
Red cell pyruvate kinase deficiency in Spain: A study of 15 cases.
Red cell pyruvate kinase deficiency. The effect of splenectomy.
Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene.
Red cell pyruvate kinase deficiency: adverse effect of oral contraceptives.
Red cell pyruvate kinase deficiency: an optimised assay.
Red cell pyruvate kinase deficiency: from genetics to clinical manifestations.
Red cell pyruvate kinase deficiency: molecular and clinical aspects.
Red-cell amino acid transport. Evidence for the presence of system ASC in mature human red blood cells.
Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency.
Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency.
Renal allograft tolerance in DLA-identical and haploidentical dogs after nonmyeloablative conditioning and transient immunosuppression with cyclosporine and mycophenolate mofetil.
Reprogramming homing endonuclease specificity through computational design and directed evolution.
Rescue of Pyruvate Kinase Deficiency in Mice by Gene Therapy Using the Human Isoenzyme.
Respiratory characteristics of blood from Basenji dogs with classical erythrocyte pyruvate kinase deficiency.
Reticulocyte-dependent labeling alterations of red cell membrane in pyruvate kinase deficiency anemia.
RLS with PLMS in a child with hemolytic anemia caused by pyruvate kinase deficiency.
Roentgenographic manifestations of pyruvate kinase deficiency hemolytic anemia.
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
Salicylate-induced injury of pyruvate-kinase-deficient erythrocytes.
Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters.
Screening of pyruvate kinase deficiency and G6PD deficiency in Chinese newborn in Hong Kong.
Secondary red cell pyruvate kinase deficiency. I. Study of 30 subjects of malignant hematological disorders.
Secondary red cell pyruvate kinase deficiency. II. Biochemical studies for the mechanism of pyruvate kinase deficiency in erythroleukemia.
Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency.
Sequestration and destruction of reticulocyte in the spleen in pyruvate kinase deficiency hereditary nonspherocytic hemolytic anemia.
Severe H1N1-associated acute respiratory failure in immunocompromised children.
Severe hemolytic anemia in a Vietnamese family, associated with novel mutations in the gene encoding for pyruvate kinase.
Severe hereditary haemolytic anaemica in dogs treated by marrow trasplantation.
Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency.
Severe pyruvate kinase deficiency anemia. A case report.
Siblings with severe pyruvate kinase deficiency and a complex genotype.
Sickle cell disease in a carrier with pyruvate kinase deficiency.
Sickle cell disorders and chronic intravascular haemolysis are associated with low plasma heparin cofactor II.
Single port robotic splenectomy for pyruvate kinase deficiency in a five-year-old patient, a case report of a surgical first.
Single-nucleotide substitution in pyruvate kinase deficiency.
Six Children with Pyruvate Kinase Deficiency from One Small Town: Molecular Characterization of the PK-LR Gene.
Six novel variants in the PKLR gene associated with pyruvate kinase deficiency in Argentinian patients.
Six previously undescribed pyruvate kinase mutations causing enzyme deficiency.
Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.
Splenectomy in the treatment of hemolytic anemia.
Splenic macrophage interaction with red cells in pyruvate kinase deficiency and hereditary spherocytosis.
Spontaneous splenic rupture in primary cytomegalovirus infection.
Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.
Studies on pyruvate kinase deficiency, pyrimidine 5-'nucleotidase deficiency and adenosine deaminase overproduction.
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia.
Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency.
Successful Liver Transplants for Liver Failure Associated With Pyruvate Kinase Deficiency.
Succinylcholine in congenital pyruvate kinase deficiency.
Surface ultrastructure of pyruvate kinase-deficient erythrocytes in the Basenji dog.
Targeted next generation sequencing for the diagnosis of patients with rare congenital anemias.
The autohaemolysis test: appraisal of the method for the diagnosis of pyruvate kinase deficiency and the effect of pH and additives.
The burden of disease in pyruvate kinase deficiency: Patients' perception of the impact on health-related quality of life.
The clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study.
The dangers of iron overload in pyruvate kinase deficiency.
The Diagnostic Utility of Single Long Contiguous Stretches of Homozygosity in Patients without Parental Consanguinity.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
The diverse forms of the erythrocyte pyruvate kinase deficiency states.
The metabolic effects of oxalate on intact red blood cells.
The molecular basis of canine pyruvate kinase deficiency.
The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.
The polymorphism of nucleosid effect in pyruvate kinase deficiency.
The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
The response of the metabolic network of the red blood cell to pyruvate kinase deficiency.
The variable manifestations of disease in pyruvate kinase deficiency and their management.
Thirteen cases of pyruvate kinase deficiency found in Japan.
Three cases of hemolytic anemia with erythrocyte pyruvate kinase deficiency in Alberta.
Tight linkage of pyruvate kinase (PKLR) and glucocerebrosidase (GBA) genes.
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency.
Treatment and long-term follow-up of extrahepatic biliary obstruction with bilirubin cholelithiasis in a Somali cat with pyruvate kinase deficiency.
Two cases of pyruvate kinase deficiency: PK 'Kamakura' and PK 'Naniwa'.
Unexpectedly high but still asymptomatic iron overload in a patient with pyruvate kinase deficiency.
Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency.
Utilization of an enzyme heat stability test and erythrocyte glycolytic intermediate assays to assist in the diagnosis of canine pyruvate kinase deficiency.
Worldwide study of hematopoietic allogeneic stem cell transplantation in pyruvate kinase deficiency.
[A case of acute granulocytic leukemia with erythrocyte pyruvate kinase deficiency and bone marrow chromosome aberration (author's transl)]
[A case of familial pyruvate kinase deficiency associated with acute myelomonocytic leukemia]
[A case of pyruvate kinase deficiency]
[A family study on pyruvate kinase deficiency anemia]
[A PKLR Gene Novel Complex Mutation in Erythrocyte Pyruvate Kinase Deficiency Detected by Targeted Sequence Capture and Next Generation Sequencing].
[Abnormal Michaelis constant for phosphoenol-pyruvate associated with an erythrocyte pyruvate kinase deficiency]
[Analysis and prenatal diagnosis of PKLR gene mutations in a family with pyruvate kinase deficiency].
[Analysis of a pyruvate kinase deficiency consanguineous pedigree caused by Ile314Thr homozygous mutation].
[Biochemical study of 2 cases of congenital pyruvate kinase deficiency]
[Biochemistry and enzymatic diagnosis of red blood cell pyruvate kinase deficiency]
[Case of pyruvate kinase deficiency]
[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]
[Clinical studies on hereditary nonspherocytic anemia with erythrocyte pyruvate kinase deficiency]
[Congenital pyruvate kinase deficiency in erythrocytes: kinetic study of the enzyme and metabolic consequences]
[Constitutional hemolytic anemia due to pyruvate kinase deficiency. Study of 2 families]
[Contributions to the problem of pyruvate kinase deficiency]
[Current status of the study of pyruvate kinase deficiency]
[Deficiency of pyruvate kinase in erythrocytes: biochemical studies. Preliminary communication]
[Demonstration of an enzyme with abnormal kinetics in 2 new cases of erythrocyte pyruvate kinase deficiency]
[Diagnosis of pyruvate kinase deficiency in the presence of an elevated reticulocyte count]
[Diagnosis of pyruvate kinase deficiency]
[Effect of Magnesium Diasporal on erythrocyte pyruvate kinase activity in healthy persons and in patients with pyruvate kinase deficiency]
[Efficacy of splenectomy in 2 cases of hemolytic anemia caused by pyruvate kinase deficiency]
[Ektacytometric determination of the deformability of red blood cells in hemolytic anemia with pyruvate kinase deficiency]
[Enzymatic diagnosis of red cell pyruvate kinase deficiency]
[Erythrocyte pyruvate kinase deficiency. Report of a case]
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in a heterozygote]
[Erythrocyte pyruvate kinase deficiency: hemolytic anemia in single and double heterozygotes]
[Erythrocytic pyruvate kinase deficiency accompanied by a severe neonatal hemolytic anemia. Family study and biochemical characterization of the enzyme]
[Extramedullary hematopoiesis as differential mediastinal space-occupying lesion diagnosis]
[Familial erythrocyte ATP: pyruvate phosphotransferase deficiency]
[From gene to disease; hereditary non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
[Gene analysis and genetic diagnosis of hereditary erythrocyte abnormalities. Pyruvate kinase deficiency]
[Glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency]
[Haematopoietic stem cell transplantation in pyruvate kinase deficiency: When is it indicated?]
[Hemolytic anemia caused by pyruvate kinase deficiency and pregnancy]
[Hemolytic anemias with pyruvate kinase deficiency]
[Hereditary elliptocytosis and pyruvate kinase deficiency of the erythrocytes]
[Hereditary haemolytic anaemia due to pyruvate kinase deficiency. Prognosis of neonatal forms (author's transl)]
[HEREDITARY HEMOLYTIC ANEMIAS WITH PYRUVATE KINASE DEFICIENCY.]
[In Process Citation].
[Inherited hemolytic anemia due to pyruvate kinase deficiency: II. Density-layer centrifugation of erythrocytes (author's transl)]
[Iron overload in congenital hemolytic anemia caused by pyruvate kinase deficiency. A major late complication]
[Metabolic studies in a family with 3 cases of congenital non-spherocytic hemolytic anemia with a pyruvate kinase deficiency]
[Molecular study of red cell pyruvate kinase deficiency in 15 patients with chronic hemolytic anemia. Group of Erythropathology of Hematology and hemotherapy Association of Spain (HHAS)]
[Neutrophil pyruvate kinase deficiency]
[Non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency]
[Nonspherocytic congenital hemolytic anemia induced by a pyruvate kinase deficiency. Presentation of a clinical case]
[Nonspherocytic hemolytic anemia in pyruvate kinase deficiency]
[On indications of spleen extirpation in nonspherocytic hemolytic anemias. Favorable success in pyruvate kinase deficiency]
[Pathophysiology and laboratory tests of hemolytic anemia: with special reference to erythroenzymopathies]
[Prenatal diagnosis of homozygous pyruvate kinase deficiency]
[Problems in hemolytic anemias with pyruvate kinase deficiency. I. Clinical and hematologic picture in 4 patients]
[Problems of erythrocyte metabolism in anemias with pyruvate kinase deficiency]
[Proceedings: A new case of pyruvate kinase deficiency]
[Pyrivate kinase deficiency. II. Biochemical studies (author's transl)]
[Pyruvate kinase deficiency and some problems of glycolysis regulation]
[Pyruvate kinase deficiency ass3ciated with nonspherocytic hemolytic anemia. Biochemical hematological study of 3 cases]
[Pyruvate kinase deficiency hereditary hemolytic anemia (author's transl)]
[PYRUVATE KINASE DEFICIENCY HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA. REPORT OF TWO CASES IN A JAPANESE FAMILY AND REVIEW OF LITERATURE.]
[Pyruvate kinase deficiency in a patient with beta-thalassemia]
[Pyruvate kinase deficiency in hereditary, non-spherocytic hemolytic anemia]
[Pyruvate kinase deficiency in the German Democratic Republic]
[Pyruvate kinase deficiency in the newborn infant]
[Pyruvate kinase deficiency of erythrocytes in a case of hereditary myopathy]
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
[Pyruvate kinase deficiency. I. Clinical and hematological observations (author's transl)]
[Pyruvate kinase deficiency]
[Regulation of the carbohydrate metabolism of the erythrocytes in pyruvate kinase deficiency]
[Research on the molecular anomaly in erythrocyte pyruvate kinase deficiency]
[Significance of kinetic abnormalities of erythrocyte pyruvate kinase in congenital deficiencies]
[Splenectomized pyruvate kinase deficiency hemolytic anemia with positive Coombs' test: report of a case with family study (author's transl)]
[Studies on erythrocyte metabolism in various hemolytic anemias: with special reference to pyruvate kinase deficiency]
[The clinical and laboratory characteristics of congenital pyruvate kinase deficiency].
[The importance of determination of ferritin levels in erythrocytes]
[The modified "pink test" in the diagnosis of hereditary spherocytosis]
[Thirteen cases of erythrocyte pyruvate kinase deficiency associated with hereditary hemolytic anemia--clinical and biochemical studies (author's transl)]
[Use of nuclear magnetic resonance in the study of hemolytic anemia. Preliminary report]
[Variations in the expression of the pyruvate kinase deficiency of erythrocytes]
[Vascular complications in a case of hemolytic anemia due to pyruvate kinase deficiency]
Renal Insufficiency
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Respiratory Distress Syndrome, Newborn
A novel mutation causing pyruvate kinase deficiency responsible for a severe neonatal respiratory distress syndrome and jaundice.
Respiratory Insufficiency
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Retinal Diseases
Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders.
Retinoblastoma
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
The double dealing of cyclin D1.
Rhabdomyosarcoma
Characterization of pyruvate kinase from human rhabdomyosarcoma in relation to immunohistochemical and morphological criteria.
Rheumatic Diseases
Pre-analytical problems in the measurement of tumor type pyruvate kinase (tumor M2-PK).
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Sarcoma
Crystallization of spleen-type (M2-type) pyruvate kinase from Rhodamine sarcoma of rats and its properties.
Effect of injection of chromatins from rhodamine sarcoma into rats on pI-isozymes of liver pyruvate kinase.
Horse v-fes feline sarcoma viral oncogene homologue; pyruvate kinase, muscle type 2; plasminogen; beta spectrin, non-erythrocytic 1; thymidylate synthetase; and microsatellite LEX078 map to 1q14-q15, 1q21, 31q12-q14, 15q22, 8q12-q14, and 14q27, respectively.
Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats.
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
[Glycolysis of ascites Tawa sarcoma cells. Inhibitory effect of alanine on pyruvate kinase activity]
[Glycolytic metabolism in Tawa sarcoma cells--inhibition of pyruvate kinase activity from Tawa sarcoma cells by alanine and phenylalanine]
[Immunohistochemical demonstration of pyruvate kinase isoenzyme in the organs and a sarcoma of the hen]
[Purification of pyruvate kinase from ascites Tawa sarcoma cells]
Sarcoma, Avian
Carbohydrate metabolism in neoplastic tissue.
Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus.
Similarities between a phosphoprotein (pp60src)-associated protein kinase of Rous sarcoma virus and a cyclic adenosine 3':5'-monophosphate-independent protein kinase that phosphorylates pyruvate kinase type M2.
Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors.
Sarcoma, Kaposi
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma.
Sepsis
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2.
Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase.
Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis.
PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1? Secretion.
Protein phosphorylation in isolated hepatocytes of septic and endotoxemic rats.
Severe Combined Immunodeficiency
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Shock, Septic
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2.
Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells.
Plesiomonas shigelloides Septic Shock Leading to Death of Postsplenectomy Patient with Pyruvate Kinase Deficiency and Hemochromatosis.
Short Bowel Syndrome
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review.
Sickle Cell Trait
Human red blood cell polymorphisms and malaria.
The distribution of the parasitic fauna dictates the distribution of the haemochromatosis genes.
Skin Neoplasms
PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.
Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation.
Sleep Deprivation
Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system.
Spinal Cord Injuries
Recovery of motor function of chronic spinal cord injury by extracellular pyruvate kinase isoform M2 and the underlying mechanism.
Splenic Infarction
[Pyruvate kinase deficiency, infectious mononucleosis, hemolytic anemia with cold autoantibodies and massive splenic infarction]
Spondylarthritis
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
Sprue, Tropical
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review.
Squamous Cell Carcinoma of Head and Neck
Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer.
Staphylococcal Infections
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Neutrophil pyruvate kinase deficiency with recurrent staphylococcal infections: first reported case.
Starvation
A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.
Age-dependent changes in rat hepatic fructose 2, 6-bisphosphate, 6-phosphofructo-2-kinase/fructose 2, 6-bisphosphatase and pyruvate kinase activity in response to a high protein diet or starvation.
Age-dependent glycolysis and gluconeogenesis enzyme activities in starved-refed rats.
Alteration in liver pyruvate kinase protein and catalytic acitivity upon starvation and refeeding.
Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression.
Development of gluconeogenesis from dihydroxyacetone in rat hepatocytes during a feeding cycle and starvation.
Difference in the effect of glucagon and starvation upon L-type pyruvate kinase from rat liver.
Disruption of the phosphate-starvation response of oilseed rape suspension cells by the fungicide phosphonate.
Effect of glucagon and starvation on L-type pyruvate kinase from rat liver [proceedings]
Enzyme activities of hepatic glucose utilization in the fed and fasting genetically obese mouse at 4-5 months of age.
Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio).
Hormone-induced changes in pyruvate kinase. Effects of glucagon and starvation.
In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines.
Inhibition of carbon dioxide fixation by lead acetate in rat liver mitochondria.
Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM.
Phosphate Starvation Inducible ;Bypasses' of Adenylate and Phosphate Dependent Glycolytic Enzymes in Brassica nigra Suspension Cells.
Purification and Characterization of a Phosphoenolpyruvate Phosphatase from Brassica nigra Suspension Cells.
Starvation and feeding with a high-carbohydrate diet induce changes in the specific activity of rat hepatic pyruvate kinase.
Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.
Transcriptional and post-transcriptional regulation of L-type pyruvate kinase gene expression in rat liver.
[Effect of insulin and hydrocortisone on pyruvate kinase from the medullar and cortical layers of rabbit kidney]
[Effect of insulin and hydrocortisone on the isoenzyme composition of pyruvate kinase in the rabbit kidney]
[Effect of starvation, cortisol and insulin on the activities of pyruvate carboxylase, phosphopyruvate carboxylase (PEP-carboxykinase) and pyruvate kinase in the liver of NZo mice in various stages of diabetes]
[On molecular biology of aging. 11th communication. Enzyme adaptation, age (author's transl)]
Stomach Neoplasms
Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer.
Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.
Fecal pyruvate kinase concentrations (ELISA based on a combination of clone 1 and clone 3 antibodies) for gastric cancer screening.
Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK.
LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2.
Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.
Metformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 signaling.
MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1.
OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels.
Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer.
Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer.
Pyruvate kinase M2 contributes to cell growth in gastric cancer via aerobic glycolysis.
Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells.
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.
Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1/PKM2/GLUT1 expression.
The Value of Expression of M2-PK and VEGF in Patients with Advanced Gastric Cancer.
Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.
[Usefulness of plasma tumor M2-pyruvate kinase in the diagnosis of gastrointestinal cancer]
Testicular Neoplasms
Plasma Tumor M2-Pyruvate Kinase Levels in Different Cancer Types.
The aldolase and pyruvate kinase isoenzyme patterns in a malignant testicular tumor from a 27 year old male.
Tu-M2-PK in the blood of testicular and cubital veins in men with testicular cancer.
Thalassemia
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.
Hepcidin and Anemia: A Tight Relationship.
Next-generation sequencing unravels homozygous mutation in glucose-6-phosphate isomerase, GPIc.1040G>A (p.Arg347His) causing hemolysis in an Indian infant.
Preliminary observations on the activity of pyruvate kinase in Hb. E thalassemia disease.
Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.
Splenectomy in the treatment of hemolytic anemia.
Thiamine Deficiency
[Isoenzyme spectrum and kinetic properties of pyruvate kinase from the liver of thiamine-deficient rats]
Thrombasthenia
Renal allograft tolerance in DLA-identical and haploidentical dogs after nonmyeloablative conditioning and transient immunosuppression with cyclosporine and mycophenolate mofetil.
Thrombocytopenia
Atypical intraerythrocytic pyruvate kinase in some haematological diseases.
Intra-erythrocytary enzymes before and after splenectomy.
Thrombosis
The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis.
Variations in platelet protein associated with arterial thrombosis.
[The action of pyruvate kinase and phosphoenolpyruvate on the development of experimental thrombosis]
Thrombotic Microangiopathies
How I do in front of an hemolytic anemia of unknown etiology?
Thymus Neoplasms
Neoplastic transformation and angiogenesis in the thymus of transgenic mice expressing SV40 T and t antigen under an L-pyruvate kinase promoter (SV12 mice).
Thyroid Cancer, Papillary
Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer.
Thyroid Diseases
Value of tumor M2-PK in thyroid carcinoma: a pilot study.
Thyroid Neoplasms
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin.
Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2.
PKM2 functions as a potential oncogene and is a crucial target of miR-148a and miR-326 in thyroid tumorigenesis.
Pyruvate kinase in normal human thyroid tissue and thyroid neoplasms.
Pyruvate kinase isozymes and dedifferentiation of (neuro-)ectodermal tumors.
Subunit-specific phosphorylation of pyruvate kinase in medullary thyroid carcinomas of the rat.
Value of tumor M2-PK in thyroid carcinoma: a pilot study.
[Immunohistochemical demonstration of L- and M2-pyruvate kinase in primary renal cell carcinomas and their metastases]
Tongue Neoplasms
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Tourette Syndrome
Identification of pyruvate kinase as an antigen associated with Tourette syndrome.
Toxoplasmosis
Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies.
triose-phosphate isomerase deficiency
Increased erythrocyte deformability in fetal erythropoiesis and in erythrocytes deficient in glucose-6-phosphate dehydrogenase and other glycolytic enzymes.
Triple Negative Breast Neoplasms
Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.
Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.
Tuberculosis
Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Allosteric regulation of pyruvate kinase from Mycobacterium tuberculosis by metabolites.
Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis.
Expression, purification, and characterization of pyruvate kinase from Mycobacterium tuberculosis: A key allosteric regulatory enzyme.
Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex.
Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.
Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses.
The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: implications for in vivo growth.
Understanding the role of PknJ in Mycobacterium tuberculosis: biochemical characterization and identification of novel substrate pyruvate kinase A.
Uremia
Effect of chronic uremia on fructose 2,6-bisphosphate glycolytic and gluconeogenic enzymes in rat liver.
Effects of chronic renal failure on the regulation of pyruvate kinase.
Urinary Bladder Neoplasms
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial-Mesenchymal Transition.
Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.
Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin.
Proteomic analysis of bladder cancer by iTRAQ after Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene treatment.
Pyruvate kinase M2 inhibits the progression of bladder cancer by targeting MAKP pathway.
Tumor M2-PK: A novel urine marker of bladder cancer.
Urinary Tract Infections
Flexible Metabolism and Suppression of Latent Enzymes Are Important for Escherichia coli Adaptation to Diverse Environments within the Host.
Uterine Cervical Neoplasms
Fructose-1,6-bisphosphatase 2 represses cervical cancer progression via inhibiting aerobic glycolysis through promoting pyruvate kinase isozyme type M2 ubiquitination.
KCNQ1 opposite strand/antisense transcript 1 promotes aggressive biological behaviors of cervical cancer cells via regulating microRNA-491-5p and pyruvate kinase M1/2.
Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-?1 (TGF-?1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells.
Tumor-specific correlation of tumor M2 pyruvate kinase in pre-invasive, invasive and recurrent cervical cancer.
Uterine Cervicitis
Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma.
Virus Diseases
Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase.
Vitamin E Deficiency
A Plasma ?-Tocopherome Can Be Identified from Proteins Associated with Vitamin E Status in School-Aged Children of Nepal.
Correlation between plasma alpha-cysteine proteinase inhibitor level and pyruvate kinase activity in vitamin E-deficient rats.
Effect of ascorbic acid and vitamin E on biochemical changes associated with vitamin E deficiency in rats.
Effects of vitamin E on toxicity by minute amounts of paraquat fed continuously to rats.
Mechanisms of hemolysis in liver disease.
Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet.
The effect of dietary vitamin E and beta-carotene on oxidation processes in the rat testis.
Vitiligo
Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin.
Whooping Cough
Bordetella pertussis extract induces increase in the activities of glycolytic enzymes in mouse liver.
Wiskott-Aldrich Syndrome
Bone marrow, peripheral blood and cord blood stem cell transplantation in children: ten years' experience at Siriraj Hospital.