Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | benzoate causes transcriptional repression of phenol utilization by transcriptional inhibition of the mph operon. MphR encoding the transcriptional activator and mphN encoding the largest subunit of multi-component phenol hydroxylase in the benA mutant are significantly downregulated (about 7- and 70fold) on the basis of mRNA levels when benzoate is added to the medium | Acinetobacter calcoaceticus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter calcoaceticus | - |
strains PHEA-2 or PHEA-12 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phenol + NAD(P)H + H+ + O2 | - |
Acinetobacter calcoaceticus | catechol + NAD(P)+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MphN | - |
Acinetobacter calcoaceticus |
multi-component phenol hydroxylase | - |
Acinetobacter calcoaceticus |
Organism | Comment | Expression |
---|---|---|
Acinetobacter calcoaceticus | expression of mphN encoding the largest subunit of multi-component phenol hydroxylase is reduced 70fold in the presence of both phenol and benzoate. Repression of mphN transcription is specifically released in the presence of benzoate | down |