Application | Comment | Organism |
---|---|---|
medicine | target for antitumor and antiviral drug design | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
truncated form of UCK2 (1-250) in complex with substrates or feedback inhibitors UTP and CTP | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CTP | feedback inhibition | Homo sapiens | |
UTP | feedback inhibition | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | bound to enzyme | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
analytical ultracentrifugation | Homo sapiens |
120000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cytidine | Homo sapiens | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation | ADP + CMP | - |
? | |
ATP + uridine | Homo sapiens | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation | ADP + UMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZX2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5-fluorouridine | - |
Homo sapiens | ADP + 5-fluorouridine 5'-monophosphate | - |
? | |
ATP + cyclopentenyl-cytosine | - |
Homo sapiens | ADP + cyclopentenylcytosine 5'-monophosphate | - |
? | |
ATP + cytidine | - |
Homo sapiens | ADP + CMP | - |
? | |
ATP + cytidine | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation | Homo sapiens | ADP + CMP | - |
? | |
ATP + uridine | - |
Homo sapiens | ADP + UMP | - |
? | |
ATP + uridine | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation | Homo sapiens | ADP + UMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | asymmetric, crystal structure analysis | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | two different enzymes termed UCK1 and UCK2 with 69% sequence identity, expression of UCK 2 but not UCK1 was shown to be enhanced in cancer cells | Homo sapiens |
uridine-cytidine kinase 2 | - |
Homo sapiens |