Any feedback?
Literature summary for 2.7.7.40 extracted from
- ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto alpha-dystroglycan (2016), Nat. Commun., 7, 11534 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + D-ribitol 5-phosphate | Mus musculus | - |
diphosphate + CDP-ribitol | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q5RJG7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Mus musculus | - |
| myotube | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + D-arabitol 5-phosphate | up to 10% activity compared to D-ribitol 5-phosphate | Mus musculus | diphosphate + CDP-arabitol | - |
? | |
| CTP + D-ribitol 5-phosphate | - |
Mus musculus | diphosphate + CDP-ribitol | - |
r | |
| CTP + D-ribitol 5-phosphate | highest activity | Mus musculus | diphosphate + CDP-ribitol | - |
r | |
| CTP + D-xylitol 5-phosphate | up to 10% activity compared to D-ribitol 5-phosphate | Mus musculus | diphosphate + CDP-xylitol | - |
? | |
| additional information | the enzyme has no activity with UTP, or in the presence of CTP and 2-C-methyl-D-erythritol 4-phosphate | Mus musculus | ? | - |
- |
|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDP-ribitol pyrophosphorylase | - |
Mus musculus |
| isoprenoid synthase domain-containing protein | - |
Mus musculus |
| IspD | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | CDP-ribitol pyrophosphorylase activity of the enzyme is required for correct alpha-dystroglycan glycosylation | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
