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Gene ontology
Version 2014-12-22
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Details for ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
2.1.1.44
Gene ontology ID
GO:0052704
Definition
The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine
References
1. DOI: 10.1021/ja101721e
2. EC 2.1.1.44
3. PMID 4276459
4. PMID 5484456
5. Wikipedia: Ergothioneine
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Gene ontology
biological_process is a
cellular process is a
cellular metabolic process is a
cellular aromatic compound metabolic process is a
aromatic amino acid family metabolic process is a
aromatic amino acid family catabolic process is a
histidine catabolic process is a
ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is a
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Gene ontology
biological_process is a
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