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EC Number	Localization	Commentary	GeneOntology No.	Reference
2.4.1.66	cell surface	-	GO:0009986 AmiGO QuickGO	722865
2.4.1.66	cytoplasm	5-10% of the total activity is surface-bound, the rest is of cytoplasmic origin	GO:0005737 AmiGO QuickGO	636787
2.4.1.66	endoplasmic reticulum	-	GO:0005783 AmiGO QuickGO	675031
2.4.1.66	endoplasmic reticulum	located within the cisternae of the endoplasmic reticulum	GO:0005783 AmiGO QuickGO	636777, 636781
2.4.1.66	endoplasmic reticulum	rough and smooth	GO:0005783 AmiGO QuickGO	636773, 636774
2.4.1.66	endoplasmic reticulum	secretion of the enzyme from the endoplasmic reticulum to the extracellular space occurs via two secretory pathways, which generate two glycoforms. Enzyme molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on lysyl hydroxylase 3 glycosyltransferase activity. Enzyme found on the cell surface bypasses the Golgi complex	GO:0005783 AmiGO QuickGO	722865
2.4.1.66	extracellular	-	-	699120, 722865
2.4.1.66	extracellular	liver enzyme	-	675031
2.4.1.66	Golgi apparatus	-	GO:0005794 AmiGO QuickGO	636773, 636774
2.4.1.66	intracellular	-	GO:0005622 AmiGO QuickGO	636781

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Release 2023.1 (January 2023)