EC Number   |
Application |
Reference |
|---|
    2.7.1.74 | analysis |
deoxycytidine kinase from B-cell chronic lymphocytic leukaemia lymphocytes can be detected by use of anti-phospho-ser74 antibodies |
672894 |
| 2.7.1.74 | medicine |
ability of the designer enzymes to activate 5-substitued pyrimidines makes it possible to utilize such nucleoside analogs in suicide gene therapy or protein therapy applications that target cancer cells |
721622 |
| 2.7.1.74 | medicine |
deoxycytidine kinase overexpression substantially increases both the toxic and radiosensitizing effects of gemcitabine. Enhancement is mild in murine GI261 cells and much stronger in rat C6 and human U373 cells. Combination of enzyme overexpression, gemcitabine treatment and irradiation improves the survival rate of C6 cell bearing rats significantly |
691590 |
| 2.7.1.74 | medicine |
direct inhibition of DNA polymerases by aphidicolin stimulated enzyme in normal, acute myeloid leukaemic and HL60 promyelocytic cells |
641954 |
| 2.7.1.74 | medicine |
enzyme is active and important in anticancer and antiviral therapy due to high phosphorylation activity of prodrugs, overview |
663023 |
| 2.7.1.74 | medicine |
in gemcitabine-resistant pancreatic cancer cells, expression of deoxycytidine kinase is significantly reduced compared with that of parental cells. Treatment with siRNA targeted to deoxycytidine kinase reduces gemcitabine sensitivity without affecting cell proliferation. Downregulation of gemcitabine-related genes RRM1 and RRM2 by siRNA increases gemcitabine sensitivity and reduces cell proliferation even without gemcitabine treatment |
690454 |
| 2.7.1.74 | medicine |
interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 |
672894 |
| 2.7.1.74 | medicine |
recombinant enzyme in human A-549 lung carcinoma cells or murine NIH3T3 fibroblast cells, increase in cytotoxicity of cytosine arabinoside, 5'-aza-2'-deoxycytidine, decrease in toxicity of 2',2'-difluorodeoxycytidine |
641955 |
| 2.7.1.74 | medicine |
sequencing of gene from European and African individuals reveals 64 genetic polymorphisms. In general, African ancestry subjects show higher mRNA expression compared with subjects with European ancestry. In both groups, single nucleotide polymorphism 35708 C>T of a 3'-untranslated region is significantly associated with lower mRNA expression and with lower blast 1-beta-D-arabinofuranosylcytosine 5'-triphosphate levels in acute myeloid leukemia patients |
675605 |
| 2.7.1.74 | medicine |
thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of deoxycytidine kinase prevents the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis |
694483 |
