1.13.12.3: tryptophan 2-monooxygenase

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For detailed information about tryptophan 2-monooxygenase, go to the full flat file.

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Synonyms

IaaM, oxygenase, tryptophan 2-mono-, Pgt-IaaM, PGTG_11658, TMO, tryptophan 2-monooxygenase, tryptophan monooxygenase

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

                1.13.12.3 tryptophan 2-monooxygenase

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Results	in table
396	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
4	Expression
13	General Information
1	General Stability
42	Inhibitors
5	kcat/KM [mM/s]
12	Ki Value [mM]
25	KM Value [mM]
3	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
23	Organism
5	Pathway
2	PDB ID
4	pH Optimum
2	pH Range
10	Protein Variants
4	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
3	Specific Activity [micromol/min/mg]
4	Storage Stability
32	Substrates and Products (Substrate)
1	Subunits
15	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
16	Turnover Number [1/s]

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Cloned on EC 1.13.12.3 - tryptophan 2-monooxygenase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Pseudomonas savastanoi

-

439347, 439348

evidence for extrachromosomal nature of gene involved in indole-3-acetic acid synthesis

Pseudomonas savastanoi

-

439342

expressed in Escherichia coli as a His-tagged fusion protein

Pseudomonas savastanoi

P06617

727017

expression in Escherichia coli

2 entries

gene IaaM, the gene is constitutively expressed in plant host Arabidopsis thaliana via Ti plasmid-encoded T-DNA insertion in tranfected cells, and no transcription factor further activates its promoter IGR1b, that contains cis-regulatory binding elements. Genetic organization, overview. Transcription factor ARR1 can regulate transcription of the IaaH or IaaM genes. Promoter IGR1 drives expression of IaaH and IaaM and contains only one Wbox and AuxRE sequence motif, and this is more closely localized upstream of the IaaM than that of the IaaH TATA box

Agrobacterium tumefaciens

Q9R717

746273

gene PGTG_11658 or Pgt-IaaM, transgenic expression of gene Pgt-IaaM in Arabidopsis thaliana haustoria causes a typical auxin expression phenotype and promotes susceptibility to the bacterial pathogen Pseudomonas syringae pv. tomato DC3000, transgenic expression of gene Pgt-IaaM in Triticum aestivum leaves, phenotypes, overview. Silencing of Pgt-IaaM by wheat host-induced gene silencing reduces the pathogenicity of Puccinia graminis. Expression of Pgt-IaaM in Arabidopsis thaliana displays pleiotropic auxin-related phenotypes

Puccinia graminis f. sp. tritici

E3KNM7

745813

quantitative real time RT-PCR enzyme expression analysis

Rubrivivax benzoatilyticus

-

746257

expression in Escherichia coli

Pseudomonas savastanoi

-

439345

expression in Escherichia coli

Agrobacterium rhizogenes

-

439349