1.14.12.11: toluene dioxygenase
This is an abbreviated version!
For detailed information about toluene dioxygenase, go to the full flat file.
Word Map on EC 1.14.12.11
-
1.14.12.11
-
putida
-
naphthalene
-
trichloroethylene
-
ethylbenzene
-
chlorobenzene
-
cis-dihydrodiols
-
dihydrodiols
-
cis-dihydroxylation
-
dot-t1e
-
ring-hydroxylating
-
cis-toluene
-
indene
-
cis-diols
-
pseudoalcaligenes
-
1-indanone
-
toluene-grown
-
3-methylcatechol
-
synthesis
-
analysis
-
degradation
- 1.14.12.11
- putida
- naphthalene
- trichloroethylene
- ethylbenzene
- chlorobenzene
- cis-dihydrodiols
- dihydrodiols
-
cis-dihydroxylation
- dot-t1e
-
ring-hydroxylating
-
cis-toluene
- indene
-
cis-diols
- pseudoalcaligenes
- 1-indanone
-
toluene-grown
- 3-methylcatechol
- synthesis
- analysis
- degradation
Reaction
Synonyms
ISPTOD, ISPTOL, More, oxygenase, toluene 2,3-di-, oxygenaseTOL, TDO, Tod, todC1C2BA, toluene 2,3-dioxygenase
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 1.14.12.11 - toluene dioxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
3-cresol + NADH + H+ + O2
?
-
activity in strain UV4formation of the corresponding cis-diol and catechol
-
-
?
4-xylene + NADH + H+ + O2
4-xylenol + NAD+ + H2O
-
activity in strain 39/D
-
-
?
benzene + NADH + O2
benzene dihydrodiol + NAD+
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
ethylbenzene + NADH + O2
?
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
indole + NADH + H+ + O2
2,2'-bis(2,3-dihydro-3-oxoindolyliden) + NAD+
-
toluene dioxygenase is ubiquitous in nature and has a broad substrate range, including benzene, toluene, ethylbenzene and xylenes. The organism produces indigo from indole through the activity of TDO
i.e. indigo
-
?
xylene + NADH + O2
?
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
-
?
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
initial enzyme of toluene catabolism
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
enzyme is involved in meta pathway for catechol degradation
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
initial enzyme of toluene catabolism
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
-
?
?
-
-
the enzyme is organized in a multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system. The TDO system is composed of a reductase, TDO-R, a Rieske [2Fe2S] ferredoxin, TDO-F, and a terminal dioxygenase, TDO-O, overview. TDO-F shuttles electrons from NADH via a flavin in TDO-R to TDO-O, which catalyzes the enantioselective addition of dioxygen to the aromatic nucleus to form cis-(1R,2S)-dihydroxy-3-methylcyclohexa-3,5-diene
-
-
?
additional information
?
-
-
TodS exhibits basal autophosphorylation activity that increases in the presence of toluene and is translated as an increase in the rate of transphosphorylation of TodT
-
-
?