1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase
This is an abbreviated version!
For detailed information about dihydroceramide fatty acyl 2-hydroxylase, go to the full flat file.
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
AtFAH1, FAH1, FAH2, fatty acid 2-hydroxylase 1, plant sphingolipid fatty acid 2-hydroxylase
ECTree
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Systematic Name
Systematic Name on EC 1.14.18.7 - dihydroceramide fatty acyl 2-hydroxylase
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dihydroceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating)
The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.