1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase
This is an abbreviated version!
For detailed information about dihydroceramide fatty acyl 2-hydroxylase, go to the full flat file.
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
AtFAH1, FAH1, FAH2, fatty acid 2-hydroxylase 1, plant sphingolipid fatty acid 2-hydroxylase
ECTree
Advanced search results
Results | in table |
---|---|
1 | Activating Compound |
4 | AA Sequence |
3 | Cofactor |
4 | General Information |
6 | Organism |
1 | Pathway |
1 | Reaction |
6 | Reference |
12 | Synonyms |
1 | Systematic Name |
General Information
General Information on EC 1.14.18.7 - dihydroceramide fatty acyl 2-hydroxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
physiological function
-
Arabidopsis thaliana Bax inhibitor-1 -mediated suppression of cell death in yeast requires Saccharomyces cerevisiae fatty acid hydroxylase 1, which has a Cb5-like domain at the N terminus and interacts with Bax inhibitor-1
physiological function
expression of Arabidopsis thaliana FAH1 gene, which does not contain the cytochrome b5 domain, in the Saccharomyces cerevisiae DELTAfah1 strain produces an approximately 25fold increase in alpha-hydroxyfatty acid 26:0 and reduces the levels of its 26-carbon precursor
physiological function
interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH1 mainly 2-hydroxylates very-long-chain fatty acids. In FAH1 knock-down lines, levels of hydroxylated fatty acids 22:0, 24:0, and 26:0 are considerably lower than in wild type, whereas the level of hydroxylated fatty acid 16:0 is marginally decreased. 2-Hydroxyfatty acids are related to resistance to oxidative stress, and isoform FAH1 or 2-hydroxy very-long-chain fatty acids show particularly strong responses to oxidative stress. Isoform FAH1 interacts with Bax inhibitor-1 via cytochrome b5 and is a key factor in Bax inhibitor-1-mediated cell death suppression
physiological function
interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH2 selectively 2-hydroxylates palmitic acid in Arabidopsis. In FAH2 knock-down lines, the level of hydroxylated fatty acid 16:0 is reduced by 22.9%, whereas the levels of other 2-hydroxyfatty acids are similar to those in wild type