1.14.19.5: acyl-CoA 11-(Z)-desaturase This is an abbreviated version! For detailed information about acyl-CoA 11-(Z)-desaturase, go to the full flat file .
Reaction
long-chain acyl-CoA +
reduced acceptor +
O2 =
DELTA11-acyl-CoA +
acceptor +
2 H2O
Synonyms (Z)-11 myristoyl CoA desaturase, acyl-CoA DELTA11-desaturase, acyl-CoA desaturase, acyl-CoA Z/E11 desaturase, APTQ desaturase, bifunctional DELTA11-desaturase, bifunctional Z-DELTA11-desaturase, Cro-Z/E11, CroDELTA11 desaturase, DELTA11 desaturase, DELTA11-(Z)-desaturase, DELTA11-desaturase, DELTA11-fatty-acid desaturase, DELTA11-myristoyl-CoA desaturase, DELTA11-palmitoyl-CoA-desaturase, DELTA11-palmitoyl-coenzyme A desaturase, desat1, desaturase, myristoly coenzyme A (E)-11, Dpu-DELTA11-APSQ, Dpu-DELTA11-LPAE, EC 1.14.99.32, fatty acid DELTA11-desaturase, fatty acyl DELTA11-desaturase, LATPG1, Lca-KPVQ, MambrD11-desaturase, More, myristoyl-CoA 11-(Z) desaturase, OfuZ/E11 protein, OscZ/E11 protein, PDesat-TnDELTA11 Z protein, Sls//E11, sphingolipid long chain base delta 8 desaturase, TpDESN, Z/E11-desaturase, Z/EDELTA11
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.14.19.5 - acyl-CoA 11-(Z)-desaturase
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myristic acid + 2 ferrocytochrome b5 + O2 + 2 H+
(Z)-11-tetradecenoate + (E)-11-tetradecenoate + 2 ferricytochrome b5 + 2 H2O
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myristoyl-CoA + reduced acceptor + O2
(Z)-11-tetradecenoyl-CoA + acceptor + 2 H2O
palmitic acid + reduced acceptor + O2
hexadec-11-enoic acid + acceptor + 2 H2O
enzyme is not involved in production of polyunsaturated fatty acids
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stearoyl-CoA + reduced acceptor + O2
oleoyl-CoA + acceptor + 2 H2O
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additional information
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myristoyl-CoA + reduced acceptor + O2
(Z)-11-tetradecenoyl-CoA + acceptor + 2 H2O
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a single enzyme may be responsible for the formation of both (Z)- and (E)-11-tetradecanoic acids. It is also possible that two mechanistically identical discrete enzymes are involved in each desaturation
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myristoyl-CoA + reduced acceptor + O2
(Z)-11-tetradecenoyl-CoA + acceptor + 2 H2O
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enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
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myristoyl-CoA + reduced acceptor + O2
(Z)-11-tetradecenoyl-CoA + acceptor + 2 H2O
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enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
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additional information
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heterologous expression in yeast shows that Dpu-D11-LPAE produces large amounts of DELTA11-monoenoic acids, in particular the Z11-16:Me and Z11-18:Me in a 1.5:1 ratio. When supplemented with the Z9-16:Me, yeast extracts of Dpu-D112-LPAE contained no 9,11-16:Me, but contain small amounts of E9,Z11-and E9,E11-16:Me when supplemented with E9-16:Me
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additional information
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heterologous expression in yeast shows that Dpu-DELTA11-APSQ produces a series of mono-unsaturated products. These monoenes are identified as DELTA8-12:Me, DELTA 8-14:Me and DELTA 8-16:Me. When supplemented with the Z9-16:acid, yeast cells transformed with Dpu-DELTA11-APSQ do not produce the DELTA8-unsaturated fatty acid methyl esters, but produce significant amount of di-unsaturated 9,11-C16 methylesters
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catalyses key reactions leading to mono- and di-unsaturated fatty acyl-moities
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catalyses key reactions leading to mono- and di-unsaturated fatty acyl-moities
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DELTA11-desaturase is involved in the biosynthesis of Z/E11-14:OAc
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DELTA11-desaturase is involved in the biosynthesis of Z/E11-14:OAc
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the enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
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all unsaturated pheromone products are produced via a DELTA11 Z-desaturation mechanism
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all unsaturated pheromone products are produced via a DELTA11 Z-desaturation mechanism
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