1.2.1.84: alcohol-forming fatty acyl-CoA reductase This is an abbreviated version! For detailed information about alcohol-forming fatty acyl-CoA reductase, go to the full flat file .
Reaction
a long-chain acyl-CoA +
2 NADPH
+
2 H+
=
a long-chain alcohol +
2 NADP+
+
CoA
Synonyms alcohol-forming FAR, alcohol-forming fatty acyl-CoA reductase, CER4, CG1443, FACR, FAR, FAR1, FAR10, FAR11, FAR12, FAR13, FAR14, FAR15, FAR16, FAR17, FAR2, FAR3, FAR4, FAR5, FAR6, FAR7, FAR8, FAR9, fatty acyl coenzyme A reductase, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 3, fatty acyl-CoA:NADPH oxidoreductase (long chain alcohol forming), fatty acyl-Coenzyme A reductase, FcrA, intestinal acyl-CoA reductase, male sterility C-terminal domain, male sterility domain-containing protein 1, Maqu_2220, Maqu_2507, Ms25, peroxisomal fatty acyl-CoA reductase 1, PsFAR I, PsFAR II, RS30405, wat, Waterproof
ECTree
Localization
Localization on EC 1.2.1.84 - alcohol-forming fatty acyl-CoA reductase
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Far1 is a tail-anchored type II peroxisomal membrane protein. The transmembrane segment of Far1 is located in its C-terminus region (amino acids 466-483). The hydrophobic C-terminus of Far1 binds to Pex19p, a cytosolic receptor harboring a C-terminal CAAX motif, which is responsible for the targeting of Far1 to peroxisomes. The C-terminus of Far1 is exposed to the peroxisome matrix, whereas a large catalytic domain in its N-terminus is located outside of peroxisomes
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after heterologous expression in yeast
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the enzyme possesses 2 transmembrane domains, amino acid sites 20-42 and 499-521
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the enzyme possesses 2 transmembrane domains, amino acid sites 340-358 and 496-504
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a membrane-associated enzyme
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primarily localized in the microperoxisomes, on the cytosolic surface
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additional information
no specific colocalisation of the enzyme with the peroxisomal marker SKL
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additional information
FLAG-tagged truncated enzyme mutants Far1490 and FLAG-Far1467 are localized in the mitochondrion and cytosol, respectively, localization analysis of tagged enzyme mutants, overview
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additional information
PsFAR I is a nonsecretory protein since no signal peptide is found
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additional information
PsFAR I is a nonsecretory protein since no signal peptide is found
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additional information
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PsFAR I is a nonsecretory protein since no signal peptide is found
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additional information
PsFAR II is a nonsecretory protein since no signal peptide is found
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additional information
PsFAR II is a nonsecretory protein since no signal peptide is found
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additional information
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PsFAR II is a nonsecretory protein since no signal peptide is found
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